Hub : Genes

Stard3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	NM_001014229.1	0.03	0.02	6.7e-04	0.02	0.02	0.02	0.02	6.6e-03	1.8e-03	2.9e-03	2.3e-03
2	Brain	gene expression	Stard3	0.05	0.03	9.5e-06	0.04	0.05	0.04	0.04	1.4e-04	1.0e-05	1.7e-04	4.7e-05
3	Adipose	gene expression	Stard3	0.02	0.02	1.4e-03	0.02	0.02	0.02	0.02	2.3e-03	2.1e-03	5.0e-03	4.5e-03
4	Adipose	alternative polyA	XM_039086506.1	0.04	0.03	4.7e-03	0	0.01	0.01	0	1.1e-01	1.4e-02	3.7e-02	1.3e-01
5	Adipose	alternative polyA	NM_001014229.1	0.04	0.03	4.1e-03	0	0.01	0.01	0	1.1e-01	1.3e-02	3.6e-02	1.2e-01
6	PL	gene expression	Stard3	0.11	0.07	3.0e-05	0.02	0.03	0.04	0.04	1.6e-03	6.1e-04	4.4e-05	8.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	2.4	4.0	4.4	-2.0	2.1	2.1	2.1	-2.1	-1.5
Area under the delay curve	0.5	0.6	0.7	-0.7	0.7	0.8	0.8	-0.8	-0.6
BMI with tail	1.5	4.9	8.4	2.9	-2.8	-2.5	-1.9	1.8	-0.3
BMI without tail	0.0	0.1	0.2	0.4	-0.4	-0.4	-0.3	0.3	-0.1
Body weight	5.0	20.9	29.7	5.5	-5.4	-5.2	-4.4	4.4	1.2
Weight adjusted by age	0.2	0.2	0.3	0.6	-0.6	-0.4	-0.2	0.2	-0.3
Bone surface	0.1	0.1	0.7	0.1	0.0	0.1	0.3	-0.3	-0.8
Bone volume	0.4	0.7	2.2	-0.3	0.4	0.5	0.8	-0.8	-1.5
Breakpoint value in progressive ratio session	0.5	0.6	1.0	0.6	-0.6	-0.8	-1.0	1.0	0.5
Number of licking bursts	0.8	0.9	2.2	-0.5	0.5	0.7	1.1	-1.1	-1.5
Context. condit. distance diff. score	1.1	1.3	2.6	0.9	-0.9	-1.0	-1.1	1.1	1.6
Locomotion velocity, session 1	0.5	0.5	0.7	0.9	-0.8	-0.8	-0.7	0.7	0.1
Locomotion distance, session 1	2.6	3.4	5.0	2.2	-2.2	-2.1	-1.7	1.7	0.3
Locomotion velocity, session 2	0.4	0.5	0.7	0.6	-0.6	-0.7	-0.8	0.8	0.6
Locomotion distance, session 2	0.4	0.6	0.9	1.0	-0.9	-0.9	-0.6	0.6	-0.4
Locomotion velocity, session 3	0.2	0.2	0.3	0.1	-0.1	-0.3	-0.6	0.6	0.6
Locomotion distance, session 3	0.4	0.4	0.5	0.7	-0.7	-0.7	-0.7	0.7	0.4
Stereotopy head waving bouts, day 3	2.8	3.4	4.4	-2.1	2.1	2.0	1.8	-1.8	-0.8
Stereotopy head waving duration, day 3	0.3	0.4	0.4	-0.6	0.6	0.7	0.7	-0.7	-0.4
Locomotion velocity, session 7	0.8	0.9	1.5	1.2	-1.2	-1.1	-0.8	0.8	0.2
Locomotion distance, session 7	0.2	0.3	0.4	0.6	-0.7	-0.6	-0.4	0.4	0.4
Stereotopy head waving bouts, day 7	0.8	1.0	1.2	-0.9	0.9	1.0	1.1	-1.1	-0.7
Stereotopy head waving duration, day 7	0.3	0.3	0.4	-0.6	0.6	0.6	0.6	-0.6	-0.5
Locomotion velocity, session 8	7.1	8.4	10.0	3.2	-3.2	-3.1	-2.9	2.9	2.0
Locomotion distance, session 8	1.3	1.9	2.5	1.6	-1.6	-1.5	-1.3	1.3	0.7
Degree of sensitization distance	0.6	0.6	0.7	0.8	-0.9	-0.8	-0.7	0.7	0.7
Degree of sensitization stereotypy	1.5	1.6	2.0	-1.1	1.2	1.3	1.4	-1.4	-1.0
Conditioned locomotion	0.1	0.2	0.5	-0.4	0.4	0.3	0.1	-0.1	0.7
Cocaine response after cond. corrected	2.4	2.6	3.8	-1.1	1.2	1.5	1.9	-1.9	-1.8
Cocaine response after cond. not corrected	3.4	3.7	5.4	-1.4	1.5	1.8	2.3	-2.3	-2.0
Cocaine response before conditioning	0.4	0.4	0.6	-0.7	0.7	0.8	0.7	-0.7	-0.0
Saline control response	0.2	0.2	0.5	0.1	-0.0	0.2	0.6	-0.6	-0.7
Bone: connectivity density	2.9	4.5	5.6	-2.3	2.4	2.3	2.1	-2.1	-1.3
Bone: cortical apparent density	5.4	7.1	10.4	-3.2	3.2	3.0	2.4	-2.4	-1.2
Bone: cortical area	0.2	0.3	0.4	-0.4	0.4	0.5	0.6	-0.6	-0.4
Bone: cortical porosity	0.7	0.8	2.0	-0.5	0.5	0.7	1.0	-1.0	-1.4
Bone: cortical porosity	0.9	1.0	2.7	-0.4	0.5	0.7	1.1	-1.1	-1.6
Bone: cortical thickness	1.3	2.2	2.8	-1.7	1.6	1.7	1.5	-1.5	-0.6
Bone: cortical thickness	4.6	5.4	7.5	-2.7	2.7	2.6	2.2	-2.2	-0.9
Bone: cortical tissue density	5.4	7.1	10.4	-3.2	3.2	3.0	2.4	-2.4	-1.2
Condit. Reinf. active minus inactive responses	0.5	0.5	1.0	-1.0	1.0	0.8	0.5	-0.5	0.3
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.4	-1.2	1.1	0.9	0.4	-0.4	0.8
Condit. Reinf. active responses	0.6	0.8	1.3	-1.1	1.1	1.0	0.7	-0.7	-0.0
Condit. Reinf. inactive responses	0.5	0.6	1.1	-0.5	0.6	0.7	0.9	-0.9	-1.1
Incentive salience index mean	1.4	1.6	2.5	-1.6	1.6	1.4	1.2	-1.2	-0.4
Condit. Reinf. lever presses	1.1	1.4	1.6	-1.2	1.2	1.3	1.2	-1.2	-0.9
Condit. Reinf. active minus inactive responses	0.7	0.9	1.0	-1.0	1.0	1.0	0.9	-0.9	-0.9
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.0	-0.7	0.8	0.7	0.8	-0.8	-1.0
Condit. Reinf. active responses	1.4	2.0	2.7	-1.3	1.4	1.3	1.4	-1.4	-1.6
Condit. Reinf. inactive responses	2.2	2.7	3.1	-1.5	1.6	1.6	1.7	-1.7	-1.7
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.3	0.3	0.2	0.1	-0.1	-0.2
Condit. Reinf. lever reinforcers received	1.3	1.8	2.2	-1.4	1.4	1.3	1.3	-1.3	-1.5
Conditioned reinforcement - actives	0.8	0.8	1.0	-1.0	1.0	1.0	0.9	-0.9	-0.4
Conditioned reinforcement - inactives	1.1	1.3	2.2	-1.5	1.4	1.3	0.9	-0.9	-0.4
Conditioned locomotion	0.9	1.1	1.3	-0.9	0.9	1.0	1.1	-1.1	-1.1
Patch foraging indifference point 0 sec	1.3	2.0	3.4	-1.8	1.8	1.6	1.2	-1.2	0.1
Patch foraging indifference point AUC	0.0	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.1	0.2
Delay disc. indifference point, 0s delay	1.2	1.3	1.5	-1.2	1.2	1.2	1.2	-1.2	-0.8
Delay disc. indifference point, 16s delay	0.5	0.5	0.8	-0.9	0.9	0.8	0.5	-0.5	0.4
Delay disc. indifference point, 2s delay	2.5	2.8	4.4	-1.2	1.3	1.5	1.8	-1.8	-2.1
Delay disc. indifference point, 24s delay	0.0	0.0	0.2	-0.1	0.1	0.1	0.1	-0.1	0.4
Delay disc. indifference point, 4s delay	0.9	1.0	1.3	-0.9	0.9	0.9	1.0	-1.0	-1.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	-0.5	0.5	0.5	0.6	-0.6	-0.1
Indifference point function ln k	0.1	0.2	1.0	-0.1	0.1	0.0	-0.1	0.1	1.0
Indifference point function log k	0.1	0.2	1.0	-0.1	0.1	0.0	-0.1	0.1	1.0
Patch foraging total patch changes 0 sec	0.9	1.4	2.4	-1.6	1.5	1.3	1.0	-1.0	0.4
Patch foraging total patch changes 12 sec	5.0	6.4	7.2	-2.7	2.7	2.7	2.5	-2.5	-2.1
Patch foraging total patch changes 18 sec	0.4	0.6	0.8	-0.9	0.9	0.9	0.7	-0.7	-0.2
Patch foraging total patch changes 24 sec	1.8	2.2	2.8	-1.6	1.6	1.7	1.6	-1.5	-0.2
Patch foraging total patch changes 6 sec	1.7	2.5	3.5	-1.9	1.8	1.7	1.5	-1.5	-0.7
Patch foraging time to switch 0 sec	0.1	0.1	0.2	-0.3	0.3	0.3	0.2	-0.2	-0.5
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.1	0.1	0.1
Patch foraging water rate 12 sec	0.3	0.4	1.2	0.4	-0.4	-0.5	-0.6	0.6	1.1
Patch foraging water rate 18 sec	0.5	0.7	0.9	-0.7	0.8	0.8	0.9	-0.9	-0.9
Patch foraging water rate 24 sec	0.4	0.6	0.7	-0.8	0.8	0.7	0.7	-0.7	-0.8
Patch foraging water rate 6 sec	1.0	1.4	1.9	-1.4	1.4	1.3	1.2	-1.2	-0.6
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.5	-0.5	0.4	0.2	-0.2	0.2	0.7
Distance traveled before self-admin	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3	0.3	-0.5
Distance traveled after self-admin	1.6	1.7	2.2	1.5	-1.5	-1.5	-1.3	1.3	0.5
Extensor digitorum longus weight	8.4	33.2	38.5	6.2	-6.2	-6.1	-5.8	5.8	4.3
Bone: elastic displacement	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	-0.1	-0.2
Bone: elastic work	0.1	0.2	0.8	-0.1	0.1	0.1	0.3	-0.3	-0.9
Bone: endosteal estimation	1.8	3.9	6.2	2.5	-2.4	-2.3	-1.8	1.8	0.4
Bone: endosteal perimeter	1.5	3.1	3.9	2.0	-2.0	-1.9	-1.8	1.7	0.9
Epididymis fat weight	0.2	0.5	0.7	0.8	-0.8	-0.8	-0.7	0.7	-0.2
Delta time in closed arm before/after self-admin	3.4	3.3	4.4	2.1	-2.1	-2.0	-1.8	1.8	0.9
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.2	0.2	0.2	0.2	-0.2	-0.3
Diff in mean of infusions in LGA sessions	0.3	0.3	0.4	0.5	-0.6	-0.6	-0.7	0.7	0.4
Delay discount exponential model param	0.3	0.3	0.4	0.4	-0.5	-0.5	-0.6	0.6	0.5
Extinction: sum of active levers before priming	1.1	1.1	1.7	1.3	-1.3	-1.2	-0.9	0.9	0.4
Active lever presses in extinction session 6	1.4	1.4	4.4	-0.6	0.7	0.8	1.1	-1.1	-2.1
Bone: final force	1.4	2.2	3.9	-1.0	1.0	1.3	1.7	-1.7	-2.0
Bone: final moment	1.2	1.9	3.9	-0.8	0.9	1.1	1.6	-1.6	-2.0
Food consumed during 24 hour testing period	0.6	0.7	1.1	1.1	-1.0	-1.0	-0.8	0.8	0.2
Glucose	0.5	0.8	1.1	-0.6	0.6	0.8	1.1	-1.1	-1.0
Heart weight	2.8	4.0	5.4	2.3	-2.3	-2.3	-2.0	2.0	0.7
Delay discount hyperbolic model param	0.5	0.5	0.6	0.6	-0.6	-0.7	-0.8	0.8	0.7
Intermittent access intake day 1-15 change	0.2	0.2	0.3	-0.5	0.5	0.4	0.3	-0.3	-0.3
Intermittent access intake escalation	0.1	0.1	0.2	-0.4	0.4	0.3	0.2	-0.2	-0.4
Intermittent access intake escalation 2	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.1	0.1	-0.2
Intermitt. access day 1 inactive lever presses	1.2	1.2	2.2	-1.1	1.2	1.0	0.9	-0.9	-1.5
Intermitt. access day 15 inactive lever presses	3.4	3.7	5.0	-2.2	2.2	2.1	1.8	-1.8	-1.3
Intermitt. access escalation Index	1.1	1.0	1.4	1.2	-1.2	-1.1	-0.9	0.9	0.6
Intermittent access day 1 total infusions	0.1	0.2	0.3	-0.4	0.4	0.4	0.4	-0.4	-0.5
Intermittent access day 15 total infusions	0.3	0.3	0.5	-0.7	0.7	0.6	0.4	-0.4	-0.4
Intermittent access terminal intake (last 3 days)	0.4	0.4	0.6	-0.8	0.7	0.7	0.5	-0.6	-0.5
Intermittent access total infusions	0.0	0.0	0.1	-0.3	0.3	0.2	0.1	-0.1	-0.2
Intermittent access day 1 locomotion	0.2	0.2	0.4	-0.6	0.6	0.5	0.5	-0.5	-0.2
Intermittent access day 15 total locomotion	0.5	0.6	0.6	-0.7	0.7	0.8	0.8	-0.8	-0.7
Intermittent access total locomotion	0.5	0.6	1.0	-1.0	1.0	0.9	0.7	-0.7	-0.2
Intermittent access standard deviation	0.5	0.5	1.2	-1.1	1.0	0.8	0.4	-0.4	0.2
Left kidney weight	1.9	5.3	6.7	2.1	-2.1	-2.4	-2.6	2.6	1.9
Right kidney weight	0.3	0.8	1.0	1.0	-0.9	-1.0	-0.9	0.9	0.1
Cocaine induced anxiety	1.7	1.9	3.3	1.8	-1.7	-1.6	-1.2	1.2	-0.2
Post-drug Anxiety	0.1	0.1	0.2	0.4	-0.4	-0.3	-0.0	0.0	-0.3
Baseline Anxiety	2.0	2.2	3.1	-1.8	1.7	1.7	1.4	-1.4	-0.0
Tail length	0.7	2.1	2.8	1.2	-1.2	-1.4	-1.7	1.7	1.5
Length with tail	3.8	13.8	16.0	3.8	-3.9	-4.0	-3.9	3.9	2.5
Length without tail	3.9	8.6	11.7	3.4	-3.4	-3.3	-2.9	2.9	1.0
Times rat made contact with spout	1.5	1.8	3.1	-1.1	1.2	1.2	1.3	-1.3	-1.8
Lifetime Intake	0.0	0.0	0.1	-0.3	0.3	0.2	0.1	-0.1	-0.2
Liver weight, left	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.3	0.3	0.0
Liver weight, right	0.1	0.2	0.3	-0.6	0.6	0.4	0.2	-0.2	-0.3
Locomotor activity	0.8	1.3	2.4	-0.8	0.8	1.0	1.3	-1.3	-1.5
Locomotor testing distance	2.4	4.0	4.5	-2.0	2.0	2.1	2.1	-2.1	-1.5
Locomotor testing rearing	4.9	7.5	11.0	-3.3	3.3	3.1	2.6	-2.6	-0.9
Locomotion in novel chamber	6.2	7.6	8.6	-2.9	2.9	2.9	2.8	-2.8	-2.0
Locomotion in novel chamber post-restriction	1.7	2.0	4.9	-0.9	1.0	1.1	1.4	-1.4	-2.2
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.5	-0.5	-0.4	-0.3	0.3	-0.1
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.1	0.1	0.1	0.2	-0.2	-0.0
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.6	-0.8	0.7	0.7	0.5	-0.5	0.6
Bouts of movement, locomotor time 1	0.7	0.8	0.9	1.0	-0.9	-0.9	-0.9	0.9	0.6
Total resting periods, locomotor time 1	1.0	1.2	1.7	1.3	-1.3	-1.2	-1.0	1.0	0.5
Rest time, locomotor task time 1	0.0	0.0	0.1	0.1	-0.0	-0.0	0.1	-0.1	-0.4
Distance moved, locomotor task time 1	0.2	0.2	0.2	-0.5	0.4	0.5	0.5	-0.5	-0.3
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.3	-0.3	-0.2	-0.0	0.0	-0.1
Time >=10cm from walls, locomotor time 2	1.5	1.6	2.0	-1.4	1.3	1.4	1.3	-1.3	-0.3
Bouts of movement, locomotor time 2	0.2	0.2	0.9	-0.4	0.3	0.1	-0.2	0.2	1.0
Total resting periods, locomotor time 2	0.3	0.3	1.4	-0.2	0.1	-0.1	-0.5	0.5	1.2
Rest time, locomotor task time 2	1.0	1.2	1.4	1.2	-1.2	-1.2	-1.1	1.1	0.6
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.0	-0.0	0.1	0.3	-0.3	-0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.1	0.4	-0.4	-0.2	-0.1	0.1	0.2
Light reinforcement 1	2.1	3.7	4.7	-2.1	2.2	2.0	1.8	-1.8	-1.5
Light reinforcement 2	1.1	1.4	3.3	-0.8	0.9	1.0	1.2	-1.2	-1.8
Bone: marrow area	1.7	3.7	5.8	2.4	-2.3	-2.2	-1.7	1.7	0.4
Bone: maximum diameter	0.0	0.1	0.2	-0.1	0.1	0.2	0.3	-0.3	-0.5
Bone: maximum force	0.2	0.3	1.1	0.1	-0.0	0.2	0.5	-0.5	-1.0
Bone: maximum moment	0.1	0.2	1.0	0.3	-0.2	0.0	0.4	-0.4	-1.0
Mean time between licks in bursts	1.1	1.6	2.2	1.5	-1.4	-1.4	-1.2	1.2	0.4
Mean num. licks in bursts	0.0	0.0	0.1	-0.3	0.3	0.2	-0.0	-0.0	0.1
Cd content in liver	0.1	0.1	0.2	-0.3	0.3	0.3	0.3	-0.3	-0.5
Co content in liver	1.1	1.3	1.7	0.9	-1.0	-1.1	-1.3	1.3	1.1
Cu content in liver	0.5	0.7	1.1	0.4	-0.4	-0.7	-1.0	1.0	1.1
Fe content in liver	1.0	1.2	1.8	1.3	-1.3	-1.3	-1.0	1.0	0.4
K content in liver	0.6	0.6	1.0	-1.0	1.0	0.9	0.7	-0.7	-0.2
Mg content in liver	0.7	0.7	1.2	-1.1	1.0	0.8	0.3	-0.3	1.0
Mn content in liver	1.0	1.1	2.2	-1.5	1.4	1.2	0.7	-0.7	0.3
Na content in liver	0.5	0.5	1.3	-0.4	0.4	0.5	0.8	-0.8	-1.1
Rb content in liver	1.1	1.4	2.0	-1.4	1.4	1.3	1.1	-1.1	-0.4
Se content in liver	3.1	3.8	6.1	-2.5	2.4	2.2	1.7	-1.7	-0.9
Sr content in liver	0.2	0.2	0.6	-0.1	0.0	-0.2	-0.5	0.5	0.8
Zn content in liver	2.2	2.4	3.2	-1.8	1.8	1.6	1.4	-1.4	-1.2
Bone: minimum diameter	0.4	0.7	1.2	1.1	-1.1	-1.0	-0.7	0.7	0.1
Time in familiar zone, hab. session 1	1.5	1.4	5.0	-0.4	0.5	0.7	1.1	-1.1	-2.2
Time in novel zone, hab. session 1	0.7	0.7	1.1	-1.0	0.9	0.8	0.4	-0.4	1.0
Total zone transitions, hab. session 1	1.9	2.6	3.0	1.7	-1.7	-1.7	-1.7	1.7	1.2
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.2	0.1
Locomotion velocity, hab. session 1	0.5	0.7	0.9	0.8	-0.8	-0.9	-0.9	0.9	0.7
Time in familiar zone, hab. session 2	0.8	0.8	2.0	-0.6	0.7	0.7	0.9	-0.9	-1.4
Time in novel zone, hab. session 2	0.1	0.1	0.4	-0.4	0.4	0.3	-0.0	0.0	0.6
Total zone transitions, hab. session 2	0.6	0.8	1.2	1.1	-1.1	-1.0	-0.8	0.8	0.5
Total locomotion distance, hab. session 2	0.2	0.2	0.4	0.6	-0.5	-0.4	-0.1	0.1	-0.6
Locomotion velocity, hab. session 2	0.3	0.4	0.7	0.9	-0.8	-0.7	-0.4	0.4	-0.3
Novel to familiar place preference ratio	1.8	1.9	3.2	1.0	-1.1	-1.2	-1.5	1.5	1.8
Novelty place preference	1.6	1.6	3.6	0.8	-0.9	-1.0	-1.3	1.3	1.9
Time in novel zone, NPP test	0.7	0.7	2.3	0.3	-0.4	-0.5	-0.8	0.8	1.5
Total zone transitions, NPP test	0.3	0.4	0.9	0.9	-0.9	-0.7	-0.3	0.3	-0.4
Total locomotion distance, NPP test	0.1	0.2	0.7	0.1	-0.1	0.1	0.4	-0.4	-0.8
Locomotion velocity, NPP test	0.2	0.3	0.6	0.8	-0.7	-0.6	-0.3	0.3	-0.3
Intraocular pressure	1.8	2.5	3.1	1.8	-1.8	-1.7	-1.5	1.5	1.1
Delta distance traveled before/after self-admin	1.5	1.6	1.8	1.2	-1.3	-1.2	-1.2	1.2	1.3
Delta ambulatory time before/after self-admin	0.6	0.7	1.0	1.0	-1.0	-0.9	-0.7	0.7	0.7
Parametrial fat weight	0.9	1.8	3.4	-1.3	1.3	1.2	1.2	-1.2	-1.9
Pavlov. Cond. lever latency	3.5	4.5	5.7	1.8	-1.9	-2.0	-2.2	2.2	2.4
Pavlov. Cond. magazine entry latency	10.7	13.8	14.9	-3.8	3.8	3.9	3.8	-3.8	-3.3
Pavlov. Cond. change in total contacts	8.1	8.6	11.4	-3.4	3.4	3.2	2.8	-2.8	-1.8
Pavlov. Cond. index score	9.4	11.9	12.8	-3.3	3.4	3.5	3.6	-3.6	-3.3
Pavlov. Cond. latency score	7.5	9.6	10.5	-2.9	3.0	3.1	3.2	-3.2	-3.1
Pavlov. Cond. lever contacts	3.3	3.9	5.6	-1.6	1.7	1.8	2.1	-2.1	-2.4
Pavlov. Cond. magazine entry number	13.4	16.7	18.3	4.2	-4.3	-4.3	-4.2	4.2	3.4
Pavlov. Cond. intertrial magazine entries	1.8	2.2	2.9	1.3	-1.4	-1.4	-1.5	1.5	1.7
Pavlov. Cond. lever-magazine prob. diff.	10.3	12.8	13.6	-3.5	3.6	3.7	3.7	-3.7	-3.2
Pavlov. Cond. response bias	9.8	11.9	13.2	-3.6	3.6	3.6	3.5	-3.5	-2.8
Pavlov. Cond. lever latency	0.5	0.6	1.6	0.6	-0.6	-0.6	-0.7	0.7	1.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	0.3	-0.2	-0.1	0.1	-0.1	-0.7
Pavlov. Cond. change in total contacts	0.6	0.8	1.0	-1.0	1.0	0.9	0.8	-0.8	-0.7
Pavlov. Cond. index score	0.4	0.6	1.6	-0.4	0.5	0.5	0.7	-0.7	-1.3
Pavlov. Cond. latency score	0.3	0.4	1.3	-0.3	0.3	0.4	0.6	-0.6	-1.1
Pavlov. Cond. lever contacts	1.2	1.6	3.5	-0.9	1.0	1.1	1.3	-1.3	-1.9
Pavlov. Cond. magazine entry number	0.2	0.2	0.7	0.2	-0.2	-0.3	-0.5	0.5	0.8
Pavlov. Cond. intertrial magazine entries	2.4	3.1	5.8	1.2	-1.3	-1.5	-1.9	1.9	2.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.4	-0.2	0.3	0.4	0.6	-0.6	-1.2
Pavlov. Cond. response bias	1.5	2.0	3.8	-1.1	1.2	1.3	1.4	-1.4	-2.0
Time in closed arm before self-admin	0.9	1.0	1.7	-1.3	1.3	1.1	0.8	-0.8	0.1
Time in closed arm after self-admin	1.1	1.1	2.6	0.6	-0.6	-0.8	-1.1	1.1	1.6
Time in open arm before self-admin	2.6	2.8	3.1	1.8	-1.8	-1.8	-1.7	1.7	1.3
Time in open arm after self-admin	0.5	0.5	0.6	0.8	-0.8	-0.8	-0.7	0.7	0.5
Bone: periosteal estimation	0.2	0.3	0.7	0.8	-0.8	-0.6	-0.3	0.3	-0.3
Bone: periosteal perimeter	0.5	0.9	1.6	1.2	-1.2	-1.1	-0.7	0.7	-0.2
Bone: post-yield work	1.1	1.5	2.1	1.5	-1.4	-1.3	-1.1	1.1	0.7
Progressive ratio test 1 active lever presses	0.9	0.9	1.1	-1.1	1.0	1.1	1.0	-1.0	-0.2
Progressive ratio test 1 breakpoint	0.7	0.8	1.0	-1.0	0.9	1.0	0.9	-0.9	-0.2
Progressive ratio test 1 inactive lever presses	0.9	0.9	1.6	-1.3	1.2	1.1	0.8	-0.8	-0.2
Progressive ratio test 2 active lever presses	1.1	1.1	1.7	-1.3	1.3	1.2	1.0	-1.0	-0.2
Progressive ratio test 2 breakpoint	0.8	0.9	1.4	-1.2	1.1	1.1	0.9	-0.9	-0.1
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.4	-0.6	0.6	0.5	0.3	-0.3	-0.2
Incentive Sensitization - Responses	1.3	1.3	1.7	-1.3	1.3	1.2	1.1	-1.1	-0.6
Incentive Sensitization - Breakpoint	1.3	1.3	1.6	-1.3	1.3	1.2	1.1	-1.1	-0.7
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.6	-0.6	0.6	0.6	0.7	-0.7	-0.7
Progressive ratio	0.0	0.1	0.2	-0.1	0.1	0.1	0.2	-0.2	-0.5
Food seeking constrained by brief footshock	0.2	0.3	0.4	-0.4	0.4	0.5	0.6	-0.6	-0.6
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	-0.3	0.3	0.3	0.3	-0.3	0.1
Retroperitoneal fat weight	0.1	0.3	0.3	0.6	-0.5	-0.6	-0.4	0.4	-0.5
Reaction time number correct	0.5	0.8	1.3	1.2	-1.1	-1.0	-0.7	0.7	-0.3
Reaction time mean minus median	0.1	0.2	0.2	0.5	-0.5	-0.4	-0.4	0.4	0.4
Reaction time mean minus median AUC	0.1	0.1	0.2	-0.2	0.2	0.3	0.4	-0.4	-0.2
Reaction time num false alarms	0.8	1.1	1.5	-0.8	0.8	1.0	1.2	-1.2	-1.2
Reaction time num false alarms AUC	0.7	0.9	1.6	-0.6	0.7	0.8	1.1	-1.1	-1.3
Reaction time trials correct on left	0.5	0.8	1.3	1.2	-1.1	-1.0	-0.7	0.7	-0.3
Reaction time trials on left	0.5	0.7	1.3	1.1	-1.1	-1.0	-0.7	0.7	-0.3
Reaction time mean	0.1	0.2	0.5	-0.5	0.5	0.3	-0.0	0.0	0.7
Reaction time mean AUC	0.1	0.2	0.6	-0.4	0.4	0.2	-0.1	0.1	0.8
Median of all reaction times	0.5	0.7	1.3	-1.1	1.1	0.9	0.5	-0.5	0.4
Reaction time omissions	0.9	1.3	1.4	-1.1	1.2	1.2	1.1	-1.1	-1.0
Reaction time false alarm rate	1.0	1.4	1.7	-1.1	1.1	1.2	1.3	-1.3	-1.0
Reaction time premature initiation rate	0.3	0.5	0.9	-0.5	0.6	0.6	0.7	-0.7	-0.9
Reaction time premature initiations	0.1	0.2	0.7	0.3	-0.3	-0.2	0.0	-0.0	-0.8
Std. dev. reaction times	0.0	0.0	0.0	-0.0	0.0	0.0	0.0	-0.0	0.1
Reaction time trials completed	0.5	0.7	1.3	1.1	-1.1	-1.0	-0.7	0.7	-0.3
Reaction time trials AUC	0.4	0.6	1.0	1.0	-1.0	-0.9	-0.6	0.6	-0.2
Run reversals in cocaine runway, females	3.2	3.1	4.7	1.5	-1.6	-1.7	-1.8	1.8	2.2
Run reversals in cocaine runway, males	0.7	0.7	0.7	-0.8	0.8	0.8	0.9	-0.9	-0.7
Latency to leave start box in cocaine runway	2.0	2.1	2.6	1.5	-1.5	-1.6	-1.6	1.6	0.7
Latency to leave start box in cocaine runway, F	1.7	1.9	2.4	1.6	-1.6	-1.6	-1.4	1.4	0.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.2	0.1	-0.1	-0.4	0.4	0.5
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3	0.3	-0.2
Total sessions with >9 infusions	0.6	0.6	1.0	-1.0	0.9	0.9	0.7	-0.7	-0.0
Short access day 1 total inactive lever presses	1.6	1.7	2.3	-1.5	1.5	1.4	1.2	-1.2	-1.1
Short access day 10 total inactive lever presses	0.3	0.3	0.5	0.6	-0.6	-0.7	-0.7	0.7	-0.0
Short access day 1 total infusions	0.2	0.2	0.5	-0.7	0.7	0.5	0.2	-0.2	-0.1
Short access day 10 total infusions	0.3	0.3	0.6	-0.5	0.5	0.5	0.5	-0.5	-0.7
Short access total infusions	0.0	0.0	0.1	-0.4	0.3	0.2	-0.0	0.0	0.1
Short access day 1 locomotion	2.7	2.9	4.1	-2.0	2.0	1.9	1.6	-1.6	-0.9
Short access day 10 total locomotion	1.5	1.7	2.0	-1.4	1.4	1.4	1.3	-1.3	-0.8
Short access total locomotion	0.3	0.3	0.6	-0.8	0.7	0.6	0.4	-0.4	0.1
One hour access (0.3 mA shock)	0.0	0.0	0.0	-0.1	0.0	0.0	-0.1	0.1	0.2
Compulsive drug intake	0.7	0.7	2.9	0.3	-0.4	-0.4	-0.6	0.6	1.7
One hour access (shock baseline)	0.3	0.3	0.9	-0.4	0.5	0.4	0.4	-0.4	-1.0
Social response proportion	0.0	0.0	0.1	0.3	-0.3	-0.2	-0.1	0.1	-0.1
Social responses	0.2	0.3	1.0	-0.1	0.2	0.3	0.5	-0.5	-1.0
Social time	0.2	0.3	1.4	0.4	-0.3	-0.1	0.3	-0.3	-1.2
Soleus weight	0.5	1.3	3.1	-0.3	0.4	0.8	1.4	-1.4	-1.8
Bone: stiffness	0.1	0.1	0.4	-0.0	0.0	0.2	0.4	-0.4	-0.6
Tibialis anterior weight	1.1	3.8	5.6	2.4	-2.3	-2.2	-1.8	1.8	0.6
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.1	-0.2	0.3	0.4	0.6	-0.6	-1.1
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.5	-0.2	0.2	0.3	0.5	-0.5	-0.7
Time to tail flick, test, before self-admin	1.1	1.1	1.5	1.2	-1.2	-1.1	-0.9	0.9	0.8
Time to tail flick, test, after self-admin	0.7	0.7	2.9	-0.3	0.4	0.5	0.7	-0.7	-1.7
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.8	-0.3	0.4	0.5	0.8	-0.8	-0.9
Delta time to tail flick, test, before/after SA	3.2	2.9	3.4	-1.7	1.7	1.7	1.7	-1.7	-1.8
Tibia length	0.8	2.4	4.7	2.2	-2.1	-1.7	-1.0	1.0	-0.6
Ambulatory time before self-admin	0.2	0.2	0.3	0.5	-0.5	-0.6	-0.6	0.6	0.1
Ambulatory time after self-admin	2.5	2.7	3.9	2.0	-1.9	-1.9	-1.6	1.6	0.4
Bone: tissue strength	0.5	0.5	0.8	0.9	-0.9	-0.7	-0.6	0.6	0.1
Total heroin consumption	1.5	1.7	4.0	-1.0	1.1	1.1	1.2	-1.2	-2.0
Bone: trabecular number	5.4	8.5	9.2	-2.9	3.0	3.0	3.0	-3.0	-2.4
Bone: trabecular spacing	0.9	1.2	2.3	1.5	-1.5	-1.3	-0.8	0.8	-0.0
Bone: trabecular thickness	0.1	0.1	0.3	-0.3	0.4	0.3	0.3	-0.3	-0.5
Bone: trabecular tissue density	0.4	0.5	2.5	-0.3	0.2	0.0	-0.5	0.5	1.6
Water consumed over 24 hours	0.1	0.1	0.3	0.2	-0.2	-0.1	0.1	-0.1	-0.6
Number of responses in last shaping day	0.2	0.2	0.7	-0.5	0.4	0.2	-0.1	0.1	0.9