Hub : Genes

Srsf7-ps4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Srsf7-ps4 0.04 0.02 2.6e-04 0.01 0.01 0.01 0.01 4.9e-02 8.2e-03 1.7e-02 6.3e-02
2 IL gene expression Srsf7-ps4 0.41 0.15 4.4e-06 0.16 0.2 0.18 0.2 1.4e-04 1.6e-05 3.3e-05 1.5e-05
3 Brain gene expression Srsf7-ps4 0.06 0.04 1.4e-04 0.03 0.04 0.04 0.04 3.7e-04 2.1e-04 1.1e-04 7.6e-05
4 PL gene expression Srsf7-ps4 0.21 0.1 1.2e-15 0.17 0.15 0.15 0.16 1.5e-18 1.4e-16 8.9e-16 4.2e-17

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density1.52.55.52.3-1.6-1.30.5
Area under the delay curve0.10.10.20.1-0.2-0.50.3
BMI with tail1.75.517.9-4.21.71.00.5
BMI without tail0.40.72.1-1.40.1-0.50.8
Body weight0.10.50.6-0.60.80.8-0.6
Weight adjusted by age1.71.93.00.01.41.6-1.7
Bone surface0.40.81.50.90.40.8-1.2
Bone volume0.61.13.71.9-0.5-0.2-0.7
Breakpoint value in progressive ratio session0.40.50.91.0-0.6-0.70.4
Number of licking bursts2.22.63.80.2-1.8-1.81.9
Context. condit. distance diff. score2.53.05.8-0.5-1.5-1.92.4
Locomotion velocity, session 10.10.10.2-0.10.1-0.30.4
Locomotion distance, session 10.20.30.5-0.70.50.6-0.3
Locomotion velocity, session 21.72.02.8-1.71.61.4-0.8
Locomotion distance, session 21.21.62.0-1.31.41.4-1.0
Locomotion velocity, session 30.10.10.2-0.40.3-0.20.3
Locomotion distance, session 30.50.51.0-0.3-0.6-0.81.0
Stereotopy head waving bouts, day 30.30.40.8-0.90.80.2-0.2
Stereotopy head waving duration, day 30.00.00.1-0.20.3-0.10.1
Locomotion velocity, session 72.22.43.1-0.81.81.7-1.6
Locomotion distance, session 71.51.92.9-0.91.71.4-1.3
Stereotopy head waving bouts, day 70.30.40.50.6-0.7-0.70.5
Stereotopy head waving duration, day 70.40.51.01.0-0.8-0.60.3
Locomotion velocity, session 80.30.30.7-0.3-0.4-0.60.9
Locomotion distance, session 80.50.71.5-1.2-0.1-0.41.1
Degree of sensitization distance2.42.43.7-0.21.81.7-1.9
Degree of sensitization stereotypy0.70.81.20.8-1.1-0.90.8
Conditioned locomotion0.00.00.10.1-0.0-0.30.2
Cocaine response after cond. corrected1.71.92.5-0.61.51.5-1.6
Cocaine response after cond. not corrected2.62.85.30.11.71.8-2.3
Cocaine response before conditioning0.40.51.00.90.20.5-1.0
Saline control response0.70.91.30.1-1.1-1.01.1
Bone: connectivity density0.20.30.60.8-0.6-0.40.1
Bone: cortical apparent density3.44.410.9-3.32.11.5-0.4
Bone: cortical area1.31.92.6-0.51.61.5-1.6
Bone: cortical porosity1.01.12.51.6-1.0-0.70.4
Bone: cortical porosity0.90.92.91.7-0.8-0.4-0.0
Bone: cortical thickness0.81.32.8-1.71.30.8-0.4
Bone: cortical thickness0.20.30.4-0.10.60.6-0.6
Bone: cortical tissue density3.44.410.8-3.32.11.5-0.4
Condit. Reinf. active minus inactive responses1.71.95.72.4-1.0-0.90.2
Condit. Reinf. active-inactive response ratio1.01.13.11.8-0.9-0.70.2
Condit. Reinf. active responses1.01.24.22.0-0.4-0.3-0.5
Condit. Reinf. inactive responses0.30.40.7-0.10.70.6-0.8
Incentive salience index mean1.82.15.32.3-1.3-1.20.5
Condit. Reinf. lever presses1.21.72.01.2-1.3-1.41.2
Condit. Reinf. active minus inactive responses1.11.44.62.1-0.8-0.2-0.6
Condit. Reinf. active-inactive response ratio1.71.74.22.0-1.5-0.70.1
Condit. Reinf. active responses0.30.41.01.00.00.3-0.7
Condit. Reinf. inactive responses0.60.71.2-0.41.10.8-0.9
Condit. Reinf. lever presses0.10.10.20.30.10.3-0.4
Condit. Reinf. lever reinforcers received0.40.50.90.80.30.6-0.9
Conditioned reinforcement - actives0.10.10.30.60.0-0.10.0
Conditioned reinforcement - inactives0.30.31.01.0-0.10.2-0.4
Conditioned locomotion3.13.75.9-2.02.41.9-1.3
Patch foraging indifference point 0 sec1.22.05.6-2.41.01.20.1
Patch foraging indifference point AUC1.01.22.2-0.61.01.5-1.1
Delay disc. indifference point, 0s delay0.00.00.10.3-0.0-0.3-0.1
Delay disc. indifference point, 16s delay0.50.50.70.8-0.7-0.80.4
Delay disc. indifference point, 2s delay0.10.10.20.10.3-0.2-0.4
Delay disc. indifference point, 24s delay0.90.91.70.1-1.0-0.91.3
Delay disc. indifference point, 4s delay0.20.20.4-0.60.60.1-0.2
Delay disc. indifference point, 8s delay0.10.10.30.6-0.1-0.2-0.3
Indifference point function ln k1.21.72.8-0.5-0.9-1.71.7
Indifference point function log k1.21.72.8-0.5-0.9-1.71.7
Patch foraging total patch changes 0 sec1.22.05.4-2.31.01.20.1
Patch foraging total patch changes 12 sec0.70.91.6-0.90.81.2-0.7
Patch foraging total patch changes 18 sec0.71.02.0-1.40.81.0-0.3
Patch foraging total patch changes 24 sec0.50.61.1-1.00.40.9-0.4
Patch foraging total patch changes 6 sec1.31.94.8-2.21.11.3-0.3
Patch foraging time to switch 0 sec0.50.81.51.2-0.9-0.80.4
Patch foraging water rate 0 sec0.50.81.8-1.31.10.4-0.4
Patch foraging water rate 12 sec0.40.61.0-0.4-0.7-0.91.0
Patch foraging water rate 18 sec0.91.22.10.2-1.1-1.51.2
Patch foraging water rate 24 sec0.00.00.0-0.1-0.2-0.1-0.2
Patch foraging water rate 6 sec0.71.01.5-0.8-0.8-1.21.2
Seeking ratio, delayed vs. immediate footshock0.60.72.51.6-0.00.1-0.7
Distance traveled before self-admin1.61.74.62.10.10.5-1.5
Distance traveled after self-admin0.60.61.30.90.40.6-1.1
Extensor digitorum longus weight6.324.932.0-5.55.75.0-3.4
Bone: elastic displacement1.92.13.20.7-1.8-1.41.7
Bone: elastic work0.50.62.21.5-0.5-0.3-0.4
Bone: endosteal estimation1.43.25.22.30.71.4-2.3
Bone: endosteal perimeter0.71.32.41.40.50.9-1.5
Epididymis fat weight0.30.71.60.50.70.7-1.3
Delta time in closed arm before/after self-admin1.21.11.4-1.21.21.0-0.9
Delta time in open arm before/after self-admin2.22.14.72.2-1.5-1.10.7
Diff in mean of infusions in LGA sessions1.41.52.41.5-1.4-1.00.8
Delay discount exponential model param0.20.20.4-0.10.40.7-0.4
Extinction: sum of active levers before priming0.50.51.61.2-0.3-0.5-0.3
Active lever presses in extinction session 61.01.01.40.9-0.9-1.20.9
Bone: final force1.72.85.00.31.61.9-2.2
Bone: final moment1.42.33.90.01.51.8-2.0
Food consumed during 24 hour testing period0.81.01.50.41.01.2-1.2
Glucose1.21.83.0-0.4-1.3-1.51.7
Heart weight0.10.20.40.7-0.20.1-0.4
Delay discount hyperbolic model param0.10.10.20.10.10.4-0.2
Intermittent access intake day 1-15 change0.30.20.5-0.6-0.2-0.10.7
Intermittent access intake escalation0.30.30.6-0.3-0.4-0.40.8
Intermittent access intake escalation 20.60.61.20.2-0.8-0.81.1
Intermitt. access day 1 inactive lever presses0.00.00.1-0.30.20.1-0.1
Intermitt. access day 15 inactive lever presses0.50.50.90.9-0.7-0.70.5
Intermitt. access escalation Index0.40.30.7-0.8-0.1-0.60.6
Intermittent access day 1 total infusions0.91.11.71.1-1.0-1.30.6
Intermittent access day 15 total infusions1.01.21.80.3-1.1-1.31.2
Intermittent access terminal intake (last 3 days)0.80.81.50.0-0.8-1.21.1
Intermittent access total infusions0.80.91.70.8-0.9-1.30.8
Intermittent access day 1 locomotion0.10.10.20.20.1-0.5-0.1
Intermittent access day 15 total locomotion0.10.10.10.00.4-0.0-0.3
Intermittent access total locomotion0.10.10.3-0.20.0-0.50.4
Intermittent access standard deviation0.00.00.1-0.30.1-0.00.1
Left kidney weight0.20.51.0-0.20.71.0-0.7
Right kidney weight0.92.54.3-1.11.52.1-1.5
Cocaine induced anxiety2.52.96.0-2.41.71.6-0.5
Post-drug Anxiety0.80.92.5-1.60.70.70.2
Baseline Anxiety2.42.64.22.0-1.7-1.60.9
Tail length1.03.010.33.2-1.0-0.4-0.8
Length with tail1.03.710.73.3-0.20.8-1.9
Length without tail1.53.25.1-0.11.72.3-2.2
Times rat made contact with spout2.32.63.80.5-1.8-1.81.9
Lifetime Intake0.20.30.50.4-0.4-0.70.4
Liver weight, left2.33.75.6-0.52.02.4-2.3
Liver weight, right0.71.22.1-0.20.91.5-1.4
Locomotor activity0.00.00.1-0.20.10.3-0.1
Locomotor testing distance0.30.61.00.5-1.0-0.60.8
Locomotor testing rearing1.01.53.0-0.2-1.3-1.11.7
Locomotion in novel chamber3.84.76.4-1.82.52.3-1.9
Locomotion in novel chamber post-restriction2.32.73.7-1.51.91.6-1.6
Fecal boli incidents, locomotor time 10.00.00.1-0.1-0.2-0.10.3
Change in fecal boli incidents, locomotor task0.60.51.10.0-0.6-1.00.9
Time >=10cm from walls, locomotor time 11.31.32.5-0.51.01.6-1.1
Bouts of movement, locomotor time 10.40.41.2-1.10.60.10.2
Total resting periods, locomotor time 10.70.82.0-1.41.00.4-0.1
Rest time, locomotor task time 10.50.61.2-0.6-0.4-0.81.1
Distance moved, locomotor task time 10.00.00.10.3-0.2-0.1-0.2
Vertical activity count, locomotor time 10.10.10.3-0.10.20.5-0.5
Time >=10cm from walls, locomotor time 21.31.32.21.5-1.3-1.00.8
Bouts of movement, locomotor time 21.41.54.4-2.11.20.40.0
Total resting periods, locomotor time 21.31.44.2-2.11.00.30.1
Rest time, locomotor task time 20.40.50.8-0.9-0.2-0.40.9
Distance moved, locomotor task time 20.20.20.50.7-0.10.1-0.5
Vertical activity count, locomotor time 20.00.00.1-0.1-0.1-0.30.2
Light reinforcement 13.25.810.0-3.22.52.4-1.0
Light reinforcement 20.70.91.5-1.11.20.9-0.3
Bone: marrow area1.43.05.02.20.71.4-2.2
Bone: maximum diameter0.30.61.0-0.21.00.8-0.9
Bone: maximum force2.54.38.51.01.72.2-2.9
Bone: maximum moment2.03.56.60.71.62.0-2.6
Mean time between licks in bursts2.33.24.6-1.82.11.9-1.2
Mean num. licks in bursts0.30.40.7-0.20.80.7-0.7
Cd content in liver0.70.81.50.50.90.8-1.2
Co content in liver1.92.23.20.9-1.5-1.51.8
Cu content in liver1.61.93.31.8-1.6-1.20.7
Fe content in liver1.82.14.72.2-1.4-1.20.6
K content in liver1.61.62.2-1.21.41.5-0.9
Mg content in liver0.40.41.0-1.00.60.6-0.2
Mn content in liver0.30.30.6-0.3-0.5-0.60.8
Na content in liver0.00.00.0-0.20.10.00.0
Rb content in liver1.92.43.2-1.51.51.8-1.3
Se content in liver0.10.10.2-0.30.40.3-0.2
Sr content in liver0.20.20.3-0.3-0.2-0.40.5
Zn content in liver0.40.51.0-1.00.70.5-0.2
Bone: minimum diameter1.42.64.70.31.51.9-2.2
Time in familiar zone, hab. session 10.40.40.8-0.5-0.5-0.50.9
Time in novel zone, hab. session 12.01.94.72.2-1.2-1.20.3
Total zone transitions, hab. session 11.01.42.2-0.01.21.3-1.5
Total locomotion distance, hab. session 12.83.96.80.42.02.2-2.6
Locomotion velocity, hab. session 13.24.56.7-0.42.32.4-2.6
Time in familiar zone, hab. session 20.20.20.30.2-0.3-0.50.6
Time in novel zone, hab. session 20.30.30.50.1-0.7-0.60.6
Total zone transitions, hab. session 20.10.10.2-0.0-0.1-0.30.4
Total locomotion distance, hab. session 20.40.50.90.30.80.7-1.0
Locomotion velocity, hab. session 20.60.91.40.11.01.0-1.2
Novel to familiar place preference ratio1.01.02.11.5-1.1-0.70.3
Novelty place preference1.21.31.91.3-1.4-1.00.6
Time in novel zone, NPP test1.51.52.21.4-1.5-1.10.7
Total zone transitions, NPP test0.20.30.8-0.90.40.4-0.0
Total locomotion distance, NPP test0.60.81.30.10.91.0-1.2
Locomotion velocity, NPP test0.71.11.4-0.31.11.2-1.2
Intraocular pressure0.20.30.7-0.3-0.2-0.60.8
Delta distance traveled before/after self-admin0.30.31.0-1.00.40.10.3
Delta ambulatory time before/after self-admin0.40.41.2-1.10.60.10.2
Parametrial fat weight0.10.10.2-0.3-0.1-0.30.5
Pavlov. Cond. lever latency2.22.84.2-2.11.71.7-1.1
Pavlov. Cond. magazine entry latency1.21.54.12.0-1.0-0.90.4
Pavlov. Cond. change in total contacts1.31.42.51.6-1.0-1.20.8
Pavlov. Cond. index score2.63.34.52.1-1.8-1.91.4
Pavlov. Cond. latency score2.43.14.62.2-1.7-1.81.3
Pavlov. Cond. lever contacts2.53.03.71.5-1.8-1.91.6
Pavlov. Cond. magazine entry number2.73.47.1-2.71.61.7-1.0
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.40.20.2-0.3
Pavlov. Cond. lever-magazine prob. diff.2.02.53.51.9-1.5-1.61.2
Pavlov. Cond. response bias2.43.03.92.0-1.6-1.81.4
Pavlov. Cond. lever latency0.10.10.4-0.60.1-0.20.4
Pavlov. Cond. magazine entry latency0.20.20.40.60.10.4-0.6
Pavlov. Cond. change in total contacts0.40.51.71.3-0.4-0.1-0.4
Pavlov. Cond. index score0.30.40.80.90.10.5-0.9
Pavlov. Cond. latency score0.40.50.90.80.20.6-1.0
Pavlov. Cond. lever contacts0.20.30.80.9-0.20.1-0.5
Pavlov. Cond. magazine entry number0.30.41.2-1.10.3-0.10.4
Pavlov. Cond. intertrial magazine entries0.30.41.2-1.10.4-0.10.4
Pavlov. Cond. lever-magazine prob. diff.0.30.40.80.60.30.6-0.9
Pavlov. Cond. response bias0.50.71.31.10.00.6-1.0
Time in closed arm before self-admin1.11.33.61.9-1.1-0.50.1
Time in closed arm after self-admin0.30.30.50.30.30.6-0.7
Time in open arm before self-admin1.11.23.5-1.90.90.7-0.2
Time in open arm after self-admin1.21.33.11.8-1.1-0.80.3
Bone: periosteal estimation1.32.85.31.41.21.6-2.3
Bone: periosteal perimeter0.50.81.50.80.70.8-1.2
Bone: post-yield work1.01.32.80.90.91.0-1.7
Progressive ratio test 1 active lever presses0.10.10.2-0.20.50.3-0.3
Progressive ratio test 1 breakpoint0.20.20.3-0.30.60.5-0.4
Progressive ratio test 1 inactive lever presses0.20.20.7-0.20.50.8-0.2
Progressive ratio test 2 active lever presses0.20.30.40.6-0.6-0.50.3
Progressive ratio test 2 breakpoint0.40.40.60.4-0.7-0.80.6
Progressive ratio test 2 inactive lever presses0.20.20.40.6-0.6-0.00.5
Incentive Sensitization - Responses0.20.20.40.7-0.6-0.30.0
Incentive Sensitization - Breakpoint0.20.20.30.5-0.5-0.30.1
Sum of active levers in priming session hrs 5-60.70.72.11.5-0.6-0.6-0.0
Progressive ratio0.40.50.7-0.60.90.7-0.6
Food seeking constrained by brief footshock1.21.42.0-0.51.31.4-1.4
Seeking ratio, punishment vs. effort0.20.20.40.10.30.6-0.6
Retroperitoneal fat weight0.41.52.2-0.81.51.2-1.3
Reaction time number correct0.71.02.5-1.61.10.6-0.3
Reaction time mean minus median1.11.44.12.0-0.9-0.8-0.3
Reaction time mean minus median AUC0.91.23.01.7-0.8-1.1-0.0
Reaction time num false alarms3.04.17.5-2.72.41.6-0.7
Reaction time num false alarms AUC3.75.18.0-2.82.81.9-1.0
Reaction time trials correct on left0.71.02.5-1.61.10.6-0.3
Reaction time trials on left0.71.02.4-1.51.10.7-0.4
Reaction time mean3.14.311.63.4-1.8-1.60.1
Reaction time mean AUC3.04.110.23.2-1.8-1.70.3
Median of all reaction times3.14.310.83.3-1.8-1.70.3
Reaction time omissions1.11.52.11.0-1.4-1.01.4
Reaction time false alarm rate1.42.03.1-1.81.81.2-0.5
Reaction time premature initiation rate0.00.00.00.1-0.1-0.1-0.1
Reaction time premature initiations0.10.20.4-0.70.40.1-0.3
Std. dev. reaction times2.73.710.73.3-1.6-1.3-0.2
Reaction time trials completed0.71.02.4-1.51.10.7-0.4
Reaction time trials AUC0.60.92.2-1.50.90.5-0.3
Run reversals in cocaine runway, females1.71.72.3-0.71.51.3-1.5
Run reversals in cocaine runway, males1.61.52.1-1.21.41.4-0.8
Latency to leave start box in cocaine runway2.42.67.4-2.71.60.6-0.0
Latency to leave start box in cocaine runway, F1.01.13.6-1.90.70.20.5
Latency to leave start box in cocaine runway, M2.82.73.8-1.91.91.2-1.3
Std. dev. time between licks in bursts1.92.37.3-2.71.10.80.2
Total sessions with >9 infusions3.03.34.4-1.22.12.1-1.7
Short access day 1 total inactive lever presses0.60.61.0-0.61.00.7-0.9
Short access day 10 total inactive lever presses0.10.10.40.6-0.30.3-0.0
Short access day 1 total infusions0.90.91.6-0.31.01.1-1.3
Short access day 10 total infusions1.71.83.20.6-1.4-1.81.4
Short access total infusions0.00.00.1-0.20.30.0-0.2
Short access day 1 locomotion1.11.21.9-0.61.41.0-1.2
Short access day 10 total locomotion0.40.50.80.10.90.5-0.8
Short access total locomotion2.62.74.5-0.92.11.5-1.8
One hour access (0.3 mA shock)1.11.32.40.8-1.2-1.50.9
Compulsive drug intake0.10.10.3-0.3-0.5-0.20.4
One hour access (shock baseline)0.80.91.50.9-0.8-1.20.7
Social response proportion0.30.30.80.9-0.6-0.40.4
Social responses0.10.10.3-0.20.50.2-0.4
Social time1.01.41.61.2-1.2-1.31.0
Soleus weight1.75.17.3-1.52.72.5-2.2
Bone: stiffness2.84.38.20.61.92.3-2.9
Tibialis anterior weight2.27.613.9-3.72.92.5-1.3
Time to tail flick, vehicle, before self-admin0.20.20.5-0.7-0.20.00.6
Time to tail flick, vehicle, after self-admin0.40.40.70.5-0.9-0.40.7
Time to tail flick, test, before self-admin1.41.32.0-1.41.31.1-0.7
Time to tail flick, test, after self-admin1.41.52.7-1.61.01.4-0.2
Delta time to tail flick, vehicle, before/after SA0.30.30.90.9-0.3-0.2-0.2
Delta time to tail flick, test, before/after SA0.20.10.30.0-0.5-0.10.5
Tibia length1.85.09.32.70.91.6-3.0
Ambulatory time before self-admin1.31.43.51.9-0.10.3-1.4
Ambulatory time after self-admin0.50.50.90.10.70.8-0.9
Bone: tissue strength0.20.20.5-0.10.70.4-0.4
Total heroin consumption1.01.11.31.2-1.1-1.01.0
Bone: trabecular number0.50.82.21.5-0.8-0.5-0.1
Bone: trabecular spacing0.70.81.5-0.91.20.8-0.7
Bone: trabecular thickness3.33.96.32.5-2.2-1.81.1
Bone: trabecular tissue density0.10.20.40.20.30.6-0.6
Water consumed over 24 hours0.30.30.7-0.9-0.0-0.20.7
Number of responses in last shaping day0.10.10.2-0.40.20.40.1