Hub : Genes

Srsf3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	alternative polyA	XM_063279228.1	0.06	0.06	6.2e-03	0.02	0.03	0.02	0.02	4.7e-02	1.4e-02	2.2e-02	2.1e-02
2	BLA	alternative polyA	NM_001047907.4	0.06	0.05	7.7e-03	0.02	0.02	0.01	0.01	3.8e-02	2.8e-02	7.6e-02	7.6e-02
3	RMTg	alternative polyA	XM_063279228.1	0.23	0.25	2.4e-03	0.04	0.1	0.11	0.11	4.0e-02	1.3e-03	6.4e-04	9.3e-04
4	RMTg	alternative polyA	NM_001047907.4	0.32	0.27	7.1e-04	0.04	0.1	0.13	0.12	4.2e-02	1.2e-03	2.1e-04	3.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.3	0.6	0.8	-0.9	0.9	-0.0	-0.8
Area under the delay curve	0.8	1.0	1.3	1.1	-1.1	1.1	-0.4
BMI with tail	1.5	5.1	7.8	2.8	-2.8	2.1	-0.8
BMI without tail	1.3	3.9	6.8	2.6	-2.6	1.5	-0.0
Body weight	4.5	19.6	26.9	5.2	-5.2	4.4	-2.2
Weight adjusted by age	0.5	0.7	1.3	0.8	-0.8	1.1	-0.3
Bone surface	0.1	0.1	0.3	0.0	-0.0	0.5	-0.5
Bone volume	0.2	0.3	0.7	0.2	-0.2	0.7	-0.9
Breakpoint value in progressive ratio session	0.3	0.3	0.9	-0.2	0.2	-0.6	0.9
Number of licking bursts	0.9	1.4	2.8	-0.7	0.7	-1.4	1.7
Context. condit. distance diff. score	0.5	0.6	1.3	-0.6	0.6	-0.7	1.1
Locomotion velocity, session 1	0.6	0.6	0.9	-0.9	0.9	0.2	-1.0
Locomotion distance, session 1	2.0	2.5	4.4	-2.1	2.1	-1.2	-0.2
Locomotion velocity, session 2	0.5	0.6	1.0	-0.6	0.6	-0.9	1.0
Locomotion distance, session 2	0.6	0.9	1.3	-1.1	1.2	-0.3	-0.9
Locomotion velocity, session 3	0.2	0.3	0.5	0.7	-0.7	0.4	-0.2
Locomotion distance, session 3	0.1	0.1	0.2	-0.4	0.4	-0.5	-0.1
Stereotopy head waving bouts, day 3	1.4	1.7	2.5	1.6	-1.6	1.2	-0.6
Stereotopy head waving duration, day 3	0.2	0.2	0.4	0.4	-0.4	0.6	-0.4
Locomotion velocity, session 7	1.7	1.8	6.1	-0.2	0.2	1.1	-2.5
Locomotion distance, session 7	1.3	1.6	4.2	-1.0	1.0	0.4	-2.0
Stereotopy head waving bouts, day 7	0.7	0.8	1.4	1.2	-1.2	0.4	0.2
Stereotopy head waving duration, day 7	0.7	0.8	1.6	1.2	-1.2	0.5	0.1
Locomotion velocity, session 8	0.1	0.1	0.5	-0.0	0.1	-0.2	0.7
Locomotion distance, session 8	0.7	1.1	1.3	-1.1	1.2	-1.0	0.8
Degree of sensitization distance	0.4	0.4	1.2	-0.1	0.1	0.8	-1.1
Degree of sensitization stereotypy	0.2	0.3	0.8	0.0	-0.0	-0.5	0.9
Conditioned locomotion	1.4	1.6	2.9	1.7	-1.7	0.8	0.1
Cocaine response after cond. corrected	0.5	0.6	0.9	0.9	-0.9	0.3	0.7
Cocaine response after cond. not corrected	0.6	0.7	1.0	1.0	-0.9	0.2	1.0
Cocaine response before conditioning	0.0	0.0	0.1	0.0	-0.0	0.1	-0.4
Saline control response	0.6	0.8	1.1	0.7	-0.7	1.0	-1.0
Bone: connectivity density	0.3	0.5	0.8	-0.8	0.8	0.2	-0.9
Bone: cortical apparent density	0.0	0.0	0.0	-0.1	0.1	-0.2	0.1
Bone: cortical area	0.2	0.3	0.5	0.5	-0.5	0.7	-0.5
Bone: cortical porosity	0.0	0.0	0.0	-0.1	0.1	0.2	-0.2
Bone: cortical porosity	0.3	0.3	0.8	-0.1	0.1	0.6	-0.9
Bone: cortical thickness	0.1	0.2	0.4	-0.6	0.6	-0.3	0.1
Bone: cortical thickness	0.3	0.4	1.4	0.1	-0.1	0.4	-1.2
Bone: cortical tissue density	0.0	0.0	0.0	-0.0	-0.0	-0.2	0.2
Condit. Reinf. active minus inactive responses	0.5	0.6	1.0	-1.0	1.0	0.0	-0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	0.2	-0.2	0.5
Condit. Reinf. active responses	0.3	0.4	0.8	-0.5	0.5	0.5	-0.9
Condit. Reinf. inactive responses	0.4	0.5	1.1	-0.6	0.6	0.3	-1.0
Incentive salience index mean	0.2	0.2	0.4	-0.6	0.6	0.1	-0.3
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.1	0.1	0.3	-0.2
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	-0.9	0.9	-0.6	0.0
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.3	-0.6	0.5	-0.5	0.5
Condit. Reinf. active responses	0.3	0.5	0.7	-0.9	0.9	-0.5	-0.3
Condit. Reinf. inactive responses	0.3	0.4	1.3	0.3	-0.3	0.5	-1.2
Condit. Reinf. lever presses	2.3	3.2	5.2	-2.3	2.3	-1.6	-0.1
Condit. Reinf. lever reinforcers received	0.7	1.0	1.6	-1.3	1.3	-0.7	-0.3
Conditioned reinforcement - actives	1.1	1.9	4.0	0.8	-0.8	1.6	-2.0
Conditioned reinforcement - inactives	0.1	0.2	0.8	-0.2	0.2	0.1	-0.9
Conditioned locomotion	3.2	4.2	8.1	1.3	-1.3	2.3	-2.8
Patch foraging indifference point 0 sec	0.2	0.4	0.6	0.8	-0.8	0.4	-0.7
Patch foraging indifference point AUC	0.1	0.2	0.4	-0.5	0.5	-0.6	0.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.4	-0.4	0.5	-0.0
Delay disc. indifference point, 16s delay	0.5	0.6	1.1	0.7	-0.6	1.0	-0.6
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	-0.3	0.3	0.4	-0.8
Delay disc. indifference point, 24s delay	2.0	2.2	3.1	1.6	-1.6	1.7	-0.8
Delay disc. indifference point, 4s delay	0.9	0.9	1.5	1.2	-1.2	0.5	0.6
Delay disc. indifference point, 8s delay	1.9	2.2	2.6	1.5	-1.5	1.6	-1.4
Indifference point function ln k	0.0	0.1	0.1	-0.4	0.4	-0.1	-0.0
Indifference point function log k	0.0	0.1	0.1	-0.4	0.4	-0.1	-0.0
Patch foraging total patch changes 0 sec	0.2	0.4	0.5	0.7	-0.7	0.4	-0.7
Patch foraging total patch changes 12 sec	0.1	0.2	0.6	-0.0	0.0	-0.8	0.4
Patch foraging total patch changes 18 sec	0.3	0.5	1.0	1.0	-1.0	0.2	-0.1
Patch foraging total patch changes 24 sec	0.3	0.4	0.8	-0.6	0.6	-0.9	0.6
Patch foraging total patch changes 6 sec	0.1	0.1	0.1	0.3	-0.3	-0.3	0.3
Patch foraging time to switch 0 sec	0.5	1.0	1.7	1.3	-1.3	0.8	0.1
Patch foraging water rate 0 sec	0.1	0.1	0.2	-0.4	0.4	-0.2	-0.4
Patch foraging water rate 12 sec	0.1	0.2	0.4	-0.3	0.3	-0.6	0.5
Patch foraging water rate 18 sec	0.1	0.2	0.3	-0.6	0.5	-0.4	0.0
Patch foraging water rate 24 sec	0.7	0.9	1.6	-0.5	0.5	-1.2	1.3
Patch foraging water rate 6 sec	0.3	0.4	0.7	-0.4	0.4	-0.8	0.8
Seeking ratio, delayed vs. immediate footshock	1.6	2.0	6.4	0.2	-0.2	-1.2	2.5
Distance traveled before self-admin	0.6	0.8	1.1	1.0	-1.1	-0.3	0.8
Distance traveled after self-admin	0.7	0.9	2.6	0.4	-0.4	-0.8	1.6
Extensor digitorum longus weight	0.1	0.6	1.0	-1.0	1.0	-0.6	0.0
Bone: elastic displacement	0.0	0.0	0.0	-0.1	0.1	0.2	-0.1
Bone: elastic work	0.1	0.1	0.3	0.2	-0.2	0.6	-0.3
Bone: endosteal estimation	2.4	5.2	7.2	2.7	-2.7	2.2	-1.3
Bone: endosteal perimeter	1.1	2.3	3.9	2.0	-2.0	1.1	-0.1
Epididymis fat weight	0.4	1.4	2.5	1.6	-1.6	0.6	0.5
Delta time in closed arm before/after self-admin	1.6	1.5	2.2	1.5	-1.5	1.2	-0.5
Delta time in open arm before/after self-admin	0.4	0.4	0.6	-0.8	0.8	-0.4	-0.4
Diff in mean of infusions in LGA sessions	1.0	1.2	2.4	-0.8	0.8	-1.1	1.6
Delay discount exponential model param	0.7	0.8	1.1	-1.0	1.0	-1.0	0.4
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.3	0.3	-0.5	0.2
Active lever presses in extinction session 6	0.4	0.4	1.1	0.1	-0.1	0.8	-1.0
Bone: final force	2.9	4.6	6.5	2.6	-2.5	2.1	-0.9
Bone: final moment	2.5	3.9	5.6	2.4	-2.3	2.0	-0.9
Food consumed during 24 hour testing period	0.3	0.4	0.7	0.8	-0.8	0.4	0.4
Glucose	0.0	0.0	0.0	-0.1	0.2	0.1	0.1
Heart weight	1.0	1.5	2.7	-1.6	1.6	-0.7	0.5
Delay discount hyperbolic model param	0.5	0.5	0.7	-0.8	0.8	-0.8	0.4
Intermittent access intake day 1-15 change	0.3	0.6	0.9	0.9	-0.9	0.6	-0.3
Intermittent access intake escalation	0.5	0.9	1.1	1.0	-1.0	0.9	-0.8
Intermittent access intake escalation 2	0.3	0.3	0.7	0.3	-0.3	0.7	-0.8
Intermitt. access day 1 inactive lever presses	0.5	1.9	3.2	-1.3	1.2	-1.8	1.1
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.5	0.7	-0.7	0.2	-0.1
Intermitt. access escalation Index	1.3	1.8	3.7	-0.8	0.8	-1.6	1.9
Intermittent access day 1 total infusions	0.5	0.8	1.4	-0.8	0.9	0.4	-1.2
Intermittent access day 15 total infusions	0.3	0.5	1.2	0.1	-0.1	0.9	-1.1
Intermittent access terminal intake (last 3 days)	0.5	0.7	1.6	0.2	-0.2	1.0	-1.3
Intermittent access total infusions	0.7	0.8	2.4	-0.2	0.3	0.8	-1.5
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.4	-0.4	0.5	-0.6
Intermittent access day 15 total locomotion	2.6	4.7	6.1	2.4	-2.5	2.1	-1.5
Intermittent access total locomotion	1.5	1.7	2.3	1.2	-1.2	1.3	-1.5
Intermittent access standard deviation	0.7	1.4	2.0	1.4	-1.4	1.1	-0.6
Left kidney weight	2.6	12.0	16.1	4.0	-4.0	3.3	-2.1
Right kidney weight	4.7	21.3	27.7	5.3	-5.2	4.5	-3.2
Cocaine induced anxiety	0.1	0.1	0.2	-0.4	0.4	-0.4	0.2
Post-drug Anxiety	0.1	0.2	0.3	-0.5	0.5	-0.3	0.2
Baseline Anxiety	0.1	0.1	0.3	0.0	-0.0	-0.1	0.6
Tail length	0.7	2.9	4.2	2.0	-2.0	1.6	-0.8
Length with tail	2.0	8.6	10.5	3.2	-3.2	3.1	-2.0
Length without tail	2.9	9.2	11.1	3.2	-3.2	3.3	-2.3
Times rat made contact with spout	1.8	2.0	3.3	-1.8	1.8	-1.1	-0.5
Lifetime Intake	0.9	1.1	3.1	0.1	-0.1	1.1	-1.8
Liver weight, left	1.3	2.1	3.3	1.8	-1.8	1.2	-0.6
Liver weight, right	1.7	2.9	5.2	2.3	-2.3	1.1	0.2
Locomotor activity	0.4	0.7	1.9	0.4	-0.4	-0.7	1.4
Locomotor testing distance	0.3	0.6	1.6	0.1	-0.1	-0.9	1.3
Locomotor testing rearing	0.4	0.8	1.5	1.2	-1.2	0.3	0.3
Locomotion in novel chamber	0.3	0.4	0.4	-0.6	0.7	-0.5	0.6
Locomotion in novel chamber post-restriction	1.3	2.1	2.8	1.7	-1.7	1.3	-1.0
Fecal boli incidents, locomotor time 1	0.7	1.0	2.8	0.2	-0.1	1.0	-1.7
Change in fecal boli incidents, locomotor task	0.9	0.9	2.5	0.7	-0.7	-0.6	1.6
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.6	1.3	-1.3	0.2	0.7
Bouts of movement, locomotor time 1	0.1	0.2	0.2	-0.4	0.4	-0.5	-0.3
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.1	0.1	-0.2	-0.6
Rest time, locomotor task time 1	0.1	0.1	0.1	0.3	-0.3	0.4	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.1	0.4	-0.4	0.2	0.2
Vertical activity count, locomotor time 1	0.2	0.4	0.7	0.8	-0.8	0.3	0.5
Time >=10cm from walls, locomotor time 2	2.9	4.3	5.5	2.4	-2.3	2.2	-1.2
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.3	-0.3	-0.2	0.1
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.1	0.1	-0.5	0.3
Rest time, locomotor task time 2	0.7	0.9	2.3	0.0	-0.0	-1.2	1.5
Distance moved, locomotor task time 2	2.5	2.9	4.1	1.6	-1.6	2.0	-1.6
Vertical activity count, locomotor time 2	1.4	1.9	3.3	1.0	-1.1	1.8	-1.4
Light reinforcement 1	0.8	1.9	3.3	1.8	-1.8	0.4	0.8
Light reinforcement 2	1.3	2.0	3.5	1.9	-1.9	0.9	0.6
Bone: marrow area	2.6	5.6	7.6	2.8	-2.7	2.3	-1.4
Bone: maximum diameter	0.3	0.6	0.7	0.8	-0.8	0.8	-0.6
Bone: maximum force	1.4	2.4	3.2	1.5	-1.5	1.8	-1.3
Bone: maximum moment	1.2	2.1	2.8	1.3	-1.3	1.7	-1.4
Mean time between licks in bursts	0.5	1.3	1.7	-1.1	1.1	-1.3	1.1
Mean num. licks in bursts	0.6	0.9	2.8	-0.5	0.5	0.4	-1.7
Cd content in liver	0.4	0.5	1.3	0.0	0.0	0.8	-1.2
Co content in liver	1.5	1.7	2.2	1.5	-1.5	1.4	-0.9
Cu content in liver	2.0	2.4	3.9	-2.0	2.0	-1.3	0.3
Fe content in liver	1.5	1.8	2.4	1.5	-1.5	1.4	-0.9
K content in liver	0.6	0.5	0.8	-0.9	0.9	-0.7	0.2
Mg content in liver	1.2	1.2	1.5	-1.1	1.1	-1.2	1.0
Mn content in liver	0.1	0.1	0.2	0.0	-0.1	-0.3	0.4
Na content in liver	0.4	0.4	0.7	-0.4	0.4	-0.9	0.8
Rb content in liver	0.3	0.3	0.9	-0.0	0.0	0.5	-1.0
Se content in liver	1.5	1.8	1.9	-1.4	1.4	-1.3	1.2
Sr content in liver	0.3	0.3	0.7	-0.1	0.1	0.5	-0.8
Zn content in liver	0.4	0.5	0.6	-0.8	0.8	-0.6	0.7
Bone: minimum diameter	0.9	1.6	2.5	1.6	-1.6	1.2	-0.1
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.0	0.0	0.3	-0.4
Time in novel zone, hab. session 1	0.1	0.1	0.3	0.5	-0.5	0.1	0.1
Total zone transitions, hab. session 1	2.0	2.8	4.3	-2.1	2.1	-1.6	0.4
Total locomotion distance, hab. session 1	1.5	2.1	2.9	-1.7	1.7	-1.5	0.6
Locomotion velocity, hab. session 1	1.4	1.9	2.8	-1.7	1.7	-1.4	0.5
Time in familiar zone, hab. session 2	1.6	1.7	2.7	-1.1	1.1	-1.7	1.3
Time in novel zone, hab. session 2	4.2	4.2	8.3	1.3	-1.3	2.3	-2.9
Total zone transitions, hab. session 2	0.5	0.6	1.2	-0.7	0.7	-1.1	0.6
Total locomotion distance, hab. session 2	2.2	2.8	4.1	-1.7	1.7	-2.0	1.1
Locomotion velocity, hab. session 2	2.6	3.5	4.9	-2.0	1.9	-2.2	1.2
Novel to familiar place preference ratio	0.2	0.3	0.4	0.5	-0.5	0.6	-0.3
Novelty place preference	0.2	0.2	0.3	0.5	-0.4	0.6	-0.3
Time in novel zone, NPP test	0.3	0.3	0.5	0.5	-0.5	0.7	-0.4
Total zone transitions, NPP test	0.9	1.3	2.2	-1.5	1.5	-0.9	-0.2
Total locomotion distance, NPP test	0.8	1.1	1.9	-1.4	1.4	-0.6	-0.7
Locomotion velocity, NPP test	1.3	1.8	3.0	-1.7	1.7	-1.1	-0.1
Intraocular pressure	1.5	2.2	2.5	1.4	-1.4	1.6	-1.5
Delta distance traveled before/after self-admin	0.3	0.3	0.6	-0.8	0.8	0.1	-0.2
Delta ambulatory time before/after self-admin	0.2	0.3	0.6	-0.8	0.7	-0.1	0.1
Parametrial fat weight	2.3	5.5	9.5	3.1	-3.1	1.6	-0.7
Pavlov. Cond. lever latency	0.3	0.4	0.6	0.7	-0.7	-0.1	0.6
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	-0.6	0.6	0.1	-0.8
Pavlov. Cond. change in total contacts	0.7	0.7	1.0	0.8	-0.8	1.0	-0.8
Pavlov. Cond. index score	0.2	0.3	0.8	-0.3	0.3	0.5	-0.9
Pavlov. Cond. latency score	0.2	0.2	0.6	-0.2	0.2	0.4	-0.7
Pavlov. Cond. lever contacts	0.2	0.2	0.5	-0.3	0.4	0.4	-0.7
Pavlov. Cond. magazine entry number	0.4	0.5	0.9	0.9	-1.0	0.4	0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	-0.2	0.2	0.6	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.1	-0.3	0.3	0.5	-1.0
Pavlov. Cond. response bias	0.4	0.5	0.9	-0.9	0.9	-0.1	-0.5
Pavlov. Cond. lever latency	1.1	1.4	2.3	1.5	-1.5	0.8	0.8
Pavlov. Cond. magazine entry latency	1.2	1.4	3.7	0.5	-0.5	1.1	-1.9
Pavlov. Cond. change in total contacts	0.5	0.9	1.2	-1.1	1.1	-0.4	-1.0
Pavlov. Cond. index score	0.5	0.7	2.1	-0.6	0.6	0.1	-1.5
Pavlov. Cond. latency score	0.3	0.4	1.2	-0.5	0.5	0.0	-1.1
Pavlov. Cond. lever contacts	0.9	1.2	1.8	-1.3	1.4	-0.7	-1.0
Pavlov. Cond. magazine entry number	0.5	0.7	2.1	-0.2	0.2	-0.6	1.5
Pavlov. Cond. intertrial magazine entries	0.9	1.4	2.1	-0.9	0.9	-1.4	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	2.0	-0.4	0.5	0.2	-1.4
Pavlov. Cond. response bias	0.8	1.1	3.0	-0.8	0.9	0.1	-1.7
Time in closed arm before self-admin	0.3	0.4	0.7	-0.9	0.8	-0.4	0.4
Time in closed arm after self-admin	0.1	0.1	0.4	-0.1	0.1	0.6	-0.4
Time in open arm before self-admin	0.1	0.1	0.1	-0.3	0.3	-0.1	-0.3
Time in open arm after self-admin	0.4	0.5	0.7	-0.8	0.8	-0.7	-0.1
Bone: periosteal estimation	1.4	2.9	3.9	2.0	-1.9	1.7	-1.0
Bone: periosteal perimeter	0.4	0.7	1.2	1.1	-1.1	0.5	0.2
Bone: post-yield work	1.4	2.1	4.6	0.6	-0.6	1.8	-2.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.0	0.0	0.3	-0.5
Progressive ratio test 1 breakpoint	0.0	0.1	0.2	-0.2	0.2	0.1	-0.4
Progressive ratio test 1 inactive lever presses	0.5	0.7	1.2	0.8	-0.8	0.8	-1.1
Progressive ratio test 2 active lever presses	0.4	0.4	1.4	0.1	-0.1	0.6	-1.2
Progressive ratio test 2 breakpoint	0.4	0.4	1.4	0.0	-0.0	0.6	-1.2
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.6	-0.2	0.2	0.1	-0.8
Incentive Sensitization - Responses	0.4	0.6	0.8	-0.9	0.9	-0.8	0.2
Incentive Sensitization - Breakpoint	0.2	0.3	0.4	-0.6	0.6	-0.6	0.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.5	0.4	-0.1	0.0
Progressive ratio	1.6	2.5	4.3	2.1	-2.1	1.2	-0.3
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.2	0.3	0.5	-0.4
Seeking ratio, punishment vs. effort	1.0	1.4	2.7	-1.6	1.7	-0.6	0.2
Retroperitoneal fat weight	0.7	2.8	5.2	2.3	-2.3	1.0	0.2
Reaction time number correct	0.3	0.5	0.9	1.0	-1.0	0.2	-0.2
Reaction time mean minus median	0.1	0.3	0.4	0.5	-0.5	0.5	-0.6
Reaction time mean minus median AUC	0.2	0.4	0.7	0.5	-0.5	0.8	-0.7
Reaction time num false alarms	0.3	0.4	0.9	-0.5	0.5	-0.9	0.5
Reaction time num false alarms AUC	0.9	1.5	2.3	-1.1	1.1	-1.5	1.1
Reaction time trials correct on left	0.3	0.5	0.9	1.0	-1.0	0.2	-0.2
Reaction time trials on left	0.2	0.5	0.9	0.9	-1.0	0.2	-0.1
Reaction time mean	0.5	0.8	1.6	0.6	-0.6	1.0	-1.3
Reaction time mean AUC	0.8	1.3	2.0	0.9	-0.9	1.3	-1.4
Median of all reaction times	0.6	0.8	1.4	0.6	-0.6	1.0	-1.2
Reaction time omissions	0.4	0.6	1.7	0.3	-0.3	-0.6	1.3
Reaction time false alarm rate	1.3	1.8	2.4	-1.6	1.5	-1.4	0.9
Reaction time premature initiation rate	0.2	0.3	0.3	-0.5	0.5	-0.5	0.6
Reaction time premature initiations	0.1	0.1	0.3	0.2	-0.2	-0.3	0.5
Std. dev. reaction times	0.1	0.2	0.3	0.2	-0.2	0.5	-0.5
Reaction time trials completed	0.2	0.5	0.9	0.9	-1.0	0.2	-0.1
Reaction time trials AUC	0.2	0.5	0.9	0.9	-1.0	0.2	-0.0
Run reversals in cocaine runway, females	1.9	1.9	5.3	0.4	-0.4	1.4	-2.3
Run reversals in cocaine runway, males	0.6	0.6	1.3	0.5	-0.5	0.8	-1.1
Latency to leave start box in cocaine runway	0.6	0.7	1.0	-1.0	1.0	-0.6	0.7
Latency to leave start box in cocaine runway, F	0.4	0.4	0.6	-0.8	0.8	-0.4	0.5
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	0.2	-0.2	0.3
Std. dev. time between licks in bursts	0.9	1.2	3.6	0.6	-0.6	-0.6	1.9
Total sessions with >9 infusions	0.1	0.2	0.6	-0.1	0.1	0.3	-0.8
Short access day 1 total inactive lever presses	0.7	1.0	2.5	0.2	-0.3	1.2	-1.6
Short access day 10 total inactive lever presses	1.1	2.6	5.4	-0.7	0.6	-2.1	2.3
Short access day 1 total infusions	0.5	0.6	1.7	-0.6	0.6	0.3	-1.3
Short access day 10 total infusions	0.0	0.1	0.1	-0.2	0.2	-0.1	-0.3
Short access total infusions	0.7	0.9	2.8	-0.0	0.0	0.9	-1.7
Short access day 1 locomotion	0.2	0.2	0.3	-0.3	0.4	-0.6	0.5
Short access day 10 total locomotion	0.4	0.7	1.4	-0.5	0.4	-1.2	1.0
Short access total locomotion	0.1	0.1	0.3	-0.1	0.1	-0.5	0.5
One hour access (0.3 mA shock)	1.4	1.6	2.7	-1.6	1.7	-0.8	-0.4
Compulsive drug intake	2.0	2.3	3.2	-1.8	1.8	-1.4	1.0
One hour access (shock baseline)	0.3	0.5	1.5	0.1	-0.1	0.7	-1.2
Social response proportion	0.0	0.0	0.1	-0.0	0.1	-0.0	0.4
Social responses	1.0	1.3	3.7	-0.2	0.2	-1.1	1.9
Social time	0.8	1.1	2.4	-0.5	0.4	-1.3	1.6
Soleus weight	0.3	0.8	1.3	1.0	-1.0	0.4	1.1
Bone: stiffness	1.1	1.8	1.9	1.3	-1.3	1.4	-1.3
Tibialis anterior weight	0.5	1.8	2.3	-1.5	1.5	-1.4	0.9
Time to tail flick, vehicle, before self-admin	1.6	1.6	2.9	1.7	-1.7	0.1	0.9
Time to tail flick, vehicle, after self-admin	0.4	0.5	0.8	-0.9	0.9	-0.5	0.4
Time to tail flick, test, before self-admin	1.6	1.6	3.9	-0.5	0.5	-1.5	2.0
Time to tail flick, test, after self-admin	0.2	0.2	0.7	-0.0	0.0	0.3	-0.8
Delta time to tail flick, vehicle, before/after SA	1.7	1.6	2.9	-1.7	1.7	-0.1	-0.9
Delta time to tail flick, test, before/after SA	1.7	1.8	3.4	0.9	-0.9	1.4	-1.8
Tibia length	1.9	5.3	7.3	2.7	-2.7	2.2	-1.4
Ambulatory time before self-admin	0.3	0.5	0.9	0.5	-0.5	-0.7	0.9
Ambulatory time after self-admin	0.7	0.9	2.4	-0.2	0.1	-1.0	1.6
Bone: tissue strength	0.2	0.2	0.5	0.1	-0.1	0.6	-0.7
Total heroin consumption	1.2	1.4	2.2	-0.9	0.9	-1.3	1.5
Bone: trabecular number	0.6	0.9	1.4	-1.2	1.2	-0.1	-1.0
Bone: trabecular spacing	1.0	1.3	2.4	1.5	-1.5	0.6	0.3
Bone: trabecular thickness	1.2	1.5	3.0	0.7	-0.7	1.5	-1.7
Bone: trabecular tissue density	0.5	0.7	2.2	0.1	-0.1	0.8	-1.5
Water consumed over 24 hours	1.3	1.8	2.7	-1.1	1.1	-1.4	1.6
Number of responses in last shaping day	0.3	0.3	0.7	-0.8	0.8	0.0	-0.3