Hub : Genes

Srf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Srf 0.04 0.03 2.1e-03 0.01 0.01 0.01 0.02 1.7e-02 1.2e-02 1.8e-02 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density0.61.01.0-1.0
Area under the delay curve8.49.89.8-3.1
BMI with tail3.913.613.63.7
BMI without tail5.516.616.64.1
Body weight4.821.121.14.6
Weight adjusted by age0.40.70.70.8
Bone surface1.42.52.5-1.6
Bone volume0.71.31.3-1.1
Breakpoint value in progressive ratio session0.00.00.0-0.2
Number of licking bursts3.15.05.02.2
Context. condit. distance diff. score0.10.10.10.4
Locomotion velocity, session 10.50.50.50.7
Locomotion distance, session 12.32.92.91.7
Locomotion velocity, session 24.95.75.72.4
Locomotion distance, session 21.41.91.91.4
Locomotion velocity, session 30.40.40.40.6
Locomotion distance, session 31.01.11.1-1.0
Stereotopy head waving bouts, day 31.82.12.11.5
Stereotopy head waving duration, day 32.53.03.01.7
Locomotion velocity, session 70.10.10.10.3
Locomotion distance, session 70.00.00.00.2
Stereotopy head waving bouts, day 70.20.20.20.5
Stereotopy head waving duration, day 70.00.00.0-0.0
Locomotion velocity, session 80.30.30.30.6
Locomotion distance, session 81.01.41.41.2
Degree of sensitization distance1.92.02.01.4
Degree of sensitization stereotypy0.40.40.4-0.6
Conditioned locomotion2.22.62.6-1.6
Cocaine response after cond. corrected0.10.10.1-0.4
Cocaine response after cond. not corrected0.30.40.4-0.6
Cocaine response before conditioning0.00.00.0-0.0
Saline control response0.00.00.00.0
Bone: connectivity density0.91.41.4-1.2
Bone: cortical apparent density0.70.90.9-1.0
Bone: cortical area0.50.70.70.8
Bone: cortical porosity0.20.20.20.4
Bone: cortical porosity0.20.20.20.4
Bone: cortical thickness0.40.70.70.8
Bone: cortical thickness0.10.10.1-0.3
Bone: cortical tissue density0.71.01.0-1.0
Condit. Reinf. active minus inactive responses1.82.02.01.4
Condit. Reinf. active-inactive response ratio0.40.40.40.6
Condit. Reinf. active responses3.03.73.71.9
Condit. Reinf. inactive responses2.43.03.01.7
Incentive salience index mean2.22.72.71.7
Condit. Reinf. lever presses3.75.25.22.3
Condit. Reinf. active minus inactive responses0.00.10.10.2
Condit. Reinf. active-inactive response ratio0.80.90.91.0
Condit. Reinf. active responses0.00.00.00.1
Condit. Reinf. inactive responses0.00.00.0-0.2
Condit. Reinf. lever presses0.81.11.11.0
Condit. Reinf. lever reinforcers received0.00.00.00.1
Conditioned reinforcement - actives0.20.40.4-0.6
Conditioned reinforcement - inactives0.30.50.50.7
Conditioned locomotion0.30.40.40.6
Patch foraging indifference point 0 sec0.81.61.61.3
Patch foraging indifference point AUC0.50.70.70.8
Delay disc. indifference point, 0s delay2.02.22.2-1.5
Delay disc. indifference point, 16s delay12.113.313.3-3.6
Delay disc. indifference point, 2s delay3.84.24.2-2.1
Delay disc. indifference point, 24s delay1.51.61.6-1.3
Delay disc. indifference point, 4s delay3.23.33.3-1.8
Delay disc. indifference point, 8s delay4.85.65.6-2.4
Indifference point function ln k0.40.70.7-0.8
Indifference point function log k0.40.70.7-0.8
Patch foraging total patch changes 0 sec1.12.02.01.4
Patch foraging total patch changes 12 sec0.91.21.21.1
Patch foraging total patch changes 18 sec1.01.61.61.3
Patch foraging total patch changes 24 sec0.50.90.91.0
Patch foraging total patch changes 6 sec2.63.93.92.0
Patch foraging time to switch 0 sec3.57.17.1-2.7
Patch foraging water rate 0 sec1.73.53.51.9
Patch foraging water rate 12 sec4.08.38.32.9
Patch foraging water rate 18 sec1.21.81.81.4
Patch foraging water rate 24 sec2.02.82.81.7
Patch foraging water rate 6 sec0.10.20.20.5
Seeking ratio, delayed vs. immediate footshock1.72.02.0-1.4
Distance traveled before self-admin0.00.10.10.2
Distance traveled after self-admin2.42.92.91.7
Extensor digitorum longus weight0.10.30.30.6
Bone: elastic displacement0.80.90.9-1.0
Bone: elastic work0.00.00.0-0.1
Bone: endosteal estimation0.30.60.6-0.8
Bone: endosteal perimeter0.00.10.10.3
Epididymis fat weight3.211.011.03.3
Delta time in closed arm before/after self-admin0.00.00.00.1
Delta time in open arm before/after self-admin0.00.00.0-0.2
Diff in mean of infusions in LGA sessions0.70.80.80.9
Delay discount exponential model param8.69.69.63.1
Extinction: sum of active levers before priming0.00.00.00.1
Active lever presses in extinction session 60.10.10.10.3
Bone: final force0.40.70.70.8
Bone: final moment0.30.50.50.7
Food consumed during 24 hour testing period0.40.50.50.7
Glucose7.111.111.13.3
Heart weight0.10.20.20.5
Delay discount hyperbolic model param7.78.58.52.9
Intermittent access intake day 1-15 change0.00.00.00.0
Intermittent access intake escalation0.00.00.0-0.0
Intermittent access intake escalation 20.10.10.1-0.3
Intermitt. access day 1 inactive lever presses0.31.11.11.1
Intermitt. access day 15 inactive lever presses0.40.80.80.9
Intermitt. access escalation Index0.00.00.0-0.1
Intermittent access day 1 total infusions0.81.21.21.1
Intermittent access day 15 total infusions0.50.80.80.9
Intermittent access terminal intake (last 3 days)0.10.10.10.3
Intermittent access total infusions0.30.40.40.6
Intermittent access day 1 locomotion1.21.61.61.2
Intermittent access day 15 total locomotion0.91.61.61.3
Intermittent access total locomotion1.01.21.21.1
Intermittent access standard deviation1.22.62.6-1.6
Left kidney weight1.67.37.32.7
Right kidney weight1.56.96.92.6
Cocaine induced anxiety0.10.10.10.3
Post-drug Anxiety0.00.00.00.1
Baseline Anxiety0.60.70.7-0.8
Tail length1.45.45.42.3
Length with tail1.14.74.72.2
Length without tail0.62.12.11.4
Times rat made contact with spout4.85.55.52.3
Lifetime Intake0.00.00.00.0
Liver weight, left0.10.20.20.4
Liver weight, right2.23.83.82.0
Locomotor activity2.23.43.41.8
Locomotor testing distance2.13.73.71.9
Locomotor testing rearing2.34.74.72.2
Locomotion in novel chamber0.81.01.0-1.0
Locomotion in novel chamber post-restriction0.50.80.8-0.9
Fecal boli incidents, locomotor time 10.30.40.4-0.6
Change in fecal boli incidents, locomotor task0.10.10.1-0.3
Time >=10cm from walls, locomotor time 10.40.50.50.7
Bouts of movement, locomotor time 10.00.00.00.0
Total resting periods, locomotor time 10.30.30.30.5
Rest time, locomotor task time 10.50.60.6-0.8
Distance moved, locomotor task time 10.00.10.10.2
Vertical activity count, locomotor time 10.30.80.8-0.9
Time >=10cm from walls, locomotor time 20.50.80.80.9
Bouts of movement, locomotor time 20.30.50.50.7
Total resting periods, locomotor time 20.10.10.10.3
Rest time, locomotor task time 20.40.50.5-0.7
Distance moved, locomotor task time 21.31.51.51.2
Vertical activity count, locomotor time 20.10.10.1-0.4
Light reinforcement 11.53.73.71.9
Light reinforcement 22.53.83.82.0
Bone: marrow area0.30.70.7-0.8
Bone: maximum diameter0.20.40.40.6
Bone: maximum force0.00.00.00.2
Bone: maximum moment0.00.00.00.1
Mean time between licks in bursts1.12.62.6-1.6
Mean num. licks in bursts0.50.80.8-0.9
Cd content in liver1.41.61.6-1.2
Co content in liver0.10.10.1-0.3
Cu content in liver0.20.20.2-0.4
Fe content in liver0.10.10.10.3
K content in liver0.10.10.1-0.3
Mg content in liver0.30.30.3-0.5
Mn content in liver0.30.40.40.6
Na content in liver0.50.50.50.7
Rb content in liver4.35.05.0-2.2
Se content in liver1.01.21.21.1
Sr content in liver1.00.90.90.9
Zn content in liver1.71.91.9-1.4
Bone: minimum diameter0.40.70.70.8
Time in familiar zone, hab. session 10.70.70.70.8
Time in novel zone, hab. session 11.01.01.0-1.0
Total zone transitions, hab. session 14.66.46.42.5
Total locomotion distance, hab. session 14.56.46.42.5
Locomotion velocity, hab. session 14.05.75.72.4
Time in familiar zone, hab. session 22.12.22.2-1.5
Time in novel zone, hab. session 20.40.40.40.6
Total zone transitions, hab. session 22.93.83.81.9
Total locomotion distance, hab. session 23.44.44.42.1
Locomotion velocity, hab. session 22.63.53.51.9
Novel to familiar place preference ratio0.00.00.00.2
Novelty place preference0.00.00.0-0.1
Time in novel zone, NPP test0.00.00.0-0.1
Total zone transitions, NPP test6.69.59.53.1
Total locomotion distance, NPP test5.88.08.02.8
Locomotion velocity, NPP test6.38.88.83.0
Intraocular pressure0.40.60.6-0.8
Delta distance traveled before/after self-admin3.03.23.21.8
Delta ambulatory time before/after self-admin3.44.24.22.0
Parametrial fat weight4.811.311.33.4
Pavlov. Cond. lever latency2.32.92.9-1.7
Pavlov. Cond. magazine entry latency0.40.50.50.7
Pavlov. Cond. change in total contacts2.12.22.21.5
Pavlov. Cond. index score2.32.92.91.7
Pavlov. Cond. latency score1.41.81.81.4
Pavlov. Cond. lever contacts2.83.33.31.8
Pavlov. Cond. magazine entry number2.12.62.6-1.6
Pavlov. Cond. intertrial magazine entries1.01.11.1-1.1
Pavlov. Cond. lever-magazine prob. diff.2.12.62.61.6
Pavlov. Cond. response bias3.54.34.32.1
Pavlov. Cond. lever latency3.24.34.3-2.1
Pavlov. Cond. magazine entry latency2.73.33.31.8
Pavlov. Cond. change in total contacts2.84.54.52.1
Pavlov. Cond. index score5.06.76.72.6
Pavlov. Cond. latency score5.57.37.32.7
Pavlov. Cond. lever contacts3.54.84.82.2
Pavlov. Cond. magazine entry number0.91.11.1-1.0
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.1
Pavlov. Cond. lever-magazine prob. diff.5.26.96.92.6
Pavlov. Cond. response bias1.41.81.81.4
Time in closed arm before self-admin0.00.00.0-0.2
Time in closed arm after self-admin0.10.10.10.3
Time in open arm before self-admin2.32.52.51.6
Time in open arm after self-admin0.50.50.50.7
Bone: periosteal estimation0.00.10.10.3
Bone: periosteal perimeter0.91.61.61.3
Bone: post-yield work0.10.10.10.3
Progressive ratio test 1 active lever presses1.11.31.31.2
Progressive ratio test 1 breakpoint1.01.21.21.1
Progressive ratio test 1 inactive lever presses0.91.31.31.1
Progressive ratio test 2 active lever presses3.13.63.61.9
Progressive ratio test 2 breakpoint3.54.04.02.0
Progressive ratio test 2 inactive lever presses0.81.31.31.2
Incentive Sensitization - Responses1.62.22.21.5
Incentive Sensitization - Breakpoint1.72.22.21.5
Sum of active levers in priming session hrs 5-60.10.10.1-0.3
Progressive ratio0.61.01.0-1.0
Food seeking constrained by brief footshock0.10.10.10.4
Seeking ratio, punishment vs. effort0.40.60.60.8
Retroperitoneal fat weight3.012.812.83.6
Reaction time number correct0.10.10.1-0.3
Reaction time mean minus median0.10.30.3-0.5
Reaction time mean minus median AUC0.20.60.6-0.8
Reaction time num false alarms0.60.80.8-0.9
Reaction time num false alarms AUC0.40.60.6-0.8
Reaction time trials correct on left0.10.10.1-0.3
Reaction time trials on left0.00.10.1-0.3
Reaction time mean0.10.10.1-0.3
Reaction time mean AUC0.00.10.1-0.3
Median of all reaction times0.00.00.0-0.2
Reaction time omissions0.30.40.40.7
Reaction time false alarm rate0.60.80.8-0.9
Reaction time premature initiation rate1.11.51.51.2
Reaction time premature initiations0.71.31.31.1
Std. dev. reaction times0.10.20.2-0.5
Reaction time trials completed0.00.10.1-0.3
Reaction time trials AUC0.00.00.0-0.1
Run reversals in cocaine runway, females1.01.01.01.0
Run reversals in cocaine runway, males0.10.10.10.3
Latency to leave start box in cocaine runway1.82.02.01.4
Latency to leave start box in cocaine runway, F0.40.40.40.7
Latency to leave start box in cocaine runway, M4.64.34.32.1
Std. dev. time between licks in bursts1.11.51.5-1.2
Total sessions with >9 infusions0.00.00.0-0.1
Short access day 1 total inactive lever presses0.20.30.30.5
Short access day 10 total inactive lever presses0.00.10.10.3
Short access day 1 total infusions0.10.10.1-0.4
Short access day 10 total infusions0.00.00.0-0.0
Short access total infusions0.60.70.7-0.9
Short access day 1 locomotion0.00.00.0-0.2
Short access day 10 total locomotion0.40.80.8-0.9
Short access total locomotion0.40.50.5-0.7
One hour access (0.3 mA shock)0.10.10.1-0.3
Compulsive drug intake0.20.20.2-0.5
One hour access (shock baseline)0.40.60.60.8
Social response proportion0.70.80.8-0.9
Social responses1.92.52.5-1.6
Social time1.01.41.4-1.2
Soleus weight0.41.31.31.1
Bone: stiffness0.00.00.00.1
Tibialis anterior weight0.30.90.90.9
Time to tail flick, vehicle, before self-admin0.30.40.4-0.6
Time to tail flick, vehicle, after self-admin2.93.83.8-2.0
Time to tail flick, test, before self-admin3.13.23.2-1.8
Time to tail flick, test, after self-admin1.81.91.9-1.4
Delta time to tail flick, vehicle, before/after SA1.41.31.3-1.1
Delta time to tail flick, test, before/after SA0.30.30.30.6
Tibia length2.87.67.62.8
Ambulatory time before self-admin0.10.10.1-0.3
Ambulatory time after self-admin2.42.92.91.7
Bone: tissue strength0.10.10.1-0.4
Total heroin consumption0.60.70.70.8
Bone: trabecular number0.61.11.1-1.0
Bone: trabecular spacing0.30.40.40.6
Bone: trabecular thickness1.01.21.2-1.1
Bone: trabecular tissue density0.10.10.1-0.4
Water consumed over 24 hours2.63.43.41.9
Number of responses in last shaping day0.00.00.00.2