Spns3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Spns3	0.13	0.1	2.2e-04	0.1	0.07	0.1	0.1	5.0e-05	3.7e-04	3.9e-05	5.4e-05
2	NAcc	gene expression	Spns3	0.11	0.07	1.1e-10	0.07	0.09	0.08	0.09	5.4e-09	1.9e-10	5.3e-10	3.1e-10
3	BLA	gene expression	Spns3	0.06	0.05	5.6e-03	0.04	0.03	0.02	0.04	2.0e-03	7.5e-03	1.8e-02	4.7e-03
4	Brain	gene expression	Spns3	0.04	0.03	3.7e-04	0.04	0.03	0.03	0.03	1.8e-04	5.5e-04	1.1e-03	7.9e-04
5	Adipose	mRNA stability	Spns3	0.06	0.04	1.1e-05	0.03	0.03	0.03	0.03	3.1e-04	2.5e-04	3.8e-04	6.8e-04
6	Adipose	gene expression	Spns3	0.03	0.03	7.0e-04	0.01	0.01	0.01	0.01	4.5e-02	7.2e-03	9.8e-03	1.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.4	0.6	1.7	0.3	0.3	0.6	-0.8	0.8	1.3
Area under the delay curve	0.0	0.0	0.1	-0.3	0.1	-0.3	0.0	-0.1	-0.3
BMI with tail	0.2	0.8	1.0	-0.8	0.9	-0.6	-1.0	1.0	1.0
BMI without tail	0.5	1.0	1.6	-0.7	1.0	-0.5	-1.2	1.2	1.3
Body weight	0.5	2.1	6.1	0.1	0.9	0.7	-1.6	1.7	2.5
Weight adjusted by age	3.2	3.6	4.3	-2.1	2.0	-1.6	-2.0	2.0	1.6
Bone surface	1.0	1.7	2.5	-0.9	1.3	-0.7	-1.5	1.5	1.6
Bone volume	1.4	2.4	3.1	-1.2	1.6	-0.9	-1.8	1.8	1.8
Breakpoint value in progressive ratio session	0.6	0.6	1.4	-0.3	0.6	0.3	-1.1	0.9	1.2
Number of licking bursts	0.3	0.3	0.4	0.5	-0.6	0.3	0.6	-0.6	-0.6
Context. condit. distance diff. score	1.1	1.3	2.1	-0.7	1.1	-0.5	-1.3	1.4	1.5
Locomotion velocity, session 1	1.9	2.1	4.4	-0.6	1.3	0.0	-1.8	1.7	2.1
Locomotion distance, session 1	0.9	1.2	1.6	-1.1	1.2	-0.8	-1.3	1.2	1.0
Locomotion velocity, session 2	0.3	0.4	1.0	0.9	-0.5	1.0	0.3	-0.2	0.2
Locomotion distance, session 2	0.2	0.3	0.7	-0.1	0.3	0.3	-0.6	0.6	0.8
Locomotion velocity, session 3	2.2	2.5	3.5	1.3	-1.7	1.0	1.9	-1.8	-1.7
Locomotion distance, session 3	0.1	0.2	0.2	0.4	-0.4	0.3	0.5	-0.4	-0.4
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	0.2	-0.1	0.2	0.1	-0.0	0.1
Stereotopy head waving duration, day 3	0.3	0.4	1.0	-0.8	0.3	-1.0	0.1	-0.1	-0.6
Locomotion velocity, session 7	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.2	0.2	0.1
Locomotion distance, session 7	0.0	0.0	0.0	0.2	-0.1	0.1	0.1	-0.1	0.0
Stereotopy head waving bouts, day 7	1.1	1.2	1.6	-0.9	1.2	-0.7	-1.3	1.3	1.2
Stereotopy head waving duration, day 7	1.3	1.6	2.2	-1.0	1.3	-0.7	-1.5	1.4	1.4
Locomotion velocity, session 8	1.1	1.3	1.6	-1.0	1.2	-0.9	-1.2	1.2	1.1
Locomotion distance, session 8	1.3	2.0	4.2	-0.6	1.3	-0.2	-1.6	1.7	2.0
Degree of sensitization distance	0.7	0.7	0.9	-0.8	0.9	-0.6	-1.0	0.9	0.9
Degree of sensitization stereotypy	1.2	1.3	2.4	-0.6	1.1	-0.3	-1.3	1.3	1.5
Conditioned locomotion	0.8	0.9	1.6	0.5	-0.9	0.3	1.1	-1.1	-1.3
Cocaine response after cond. corrected	0.6	0.7	1.5	1.1	-0.8	1.2	0.6	-0.5	-0.0
Cocaine response after cond. not corrected	0.3	0.3	0.9	0.7	-0.5	0.9	0.2	-0.2	0.2
Cocaine response before conditioning	0.8	1.0	1.3	-1.0	1.1	-0.8	-1.1	1.1	0.9
Saline control response	0.5	0.6	0.8	-0.8	0.9	-0.5	-0.9	0.9	0.8
Bone: connectivity density	0.7	1.1	2.7	-0.2	0.8	0.2	-1.2	1.2	1.6
Bone: cortical apparent density	1.1	1.5	2.0	1.0	-1.3	0.8	1.4	-1.4	-1.4
Bone: cortical area	0.1	0.2	0.6	-0.2	-0.2	-0.4	0.4	-0.4	-0.8
Bone: cortical porosity	1.6	1.8	3.4	1.8	-1.4	1.8	1.1	-1.0	-0.3
Bone: cortical porosity	1.6	1.7	2.8	1.7	-1.4	1.7	1.2	-1.1	-0.5
Bone: cortical thickness	2.2	3.7	4.6	1.7	-2.0	1.4	2.2	-2.1	-2.0
Bone: cortical thickness	4.3	5.0	6.5	2.5	-2.4	2.5	2.2	-2.1	-1.4
Bone: cortical tissue density	0.9	1.2	1.6	0.9	-1.2	0.7	1.2	-1.3	-1.3
Condit. Reinf. active minus inactive responses	1.1	1.2	2.3	1.4	-1.2	1.5	0.9	-0.9	-0.4
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.4	1.1	-0.9	1.2	0.7	-0.7	-0.3
Condit. Reinf. active responses	0.8	0.9	1.9	1.2	-1.0	1.4	0.8	-0.7	-0.2
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.2	-0.2	0.2	0.2	-0.2	-0.2
Incentive salience index mean	1.4	1.7	3.8	1.7	-1.4	1.9	1.0	-0.9	-0.2
Condit. Reinf. lever presses	1.6	2.1	5.7	2.0	-1.4	2.4	0.8	-0.7	0.3
Condit. Reinf. active minus inactive responses	0.6	0.7	1.4	1.2	-0.9	1.1	0.7	-0.6	-0.1
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.5	1.2	-1.1	1.2	0.9	-0.8	-0.4
Condit. Reinf. active responses	0.2	0.3	0.6	0.8	-0.5	0.7	0.5	-0.3	-0.0
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.4	0.4	-0.7	-0.2	0.3	0.0
Condit. Reinf. lever presses	0.3	0.4	0.9	0.3	-0.5	-0.1	0.8	-0.7	-0.9
Condit. Reinf. lever reinforcers received	0.2	0.2	0.5	0.7	-0.5	0.5	0.5	-0.4	-0.1
Conditioned reinforcement - actives	1.0	1.0	1.2	-0.9	1.1	-0.9	-1.0	1.1	1.0
Conditioned reinforcement - inactives	2.0	2.2	2.8	-1.6	1.6	-1.4	-1.7	1.5	1.1
Conditioned locomotion	0.6	0.7	2.1	-1.0	0.8	-1.5	-0.4	0.4	-0.1
Patch foraging indifference point 0 sec	1.6	2.5	4.1	1.8	-1.8	2.0	1.3	-1.5	-0.9
Patch foraging indifference point AUC	1.6	1.8	4.0	-2.0	1.3	-1.8	-1.1	0.8	0.1
Delay disc. indifference point, 0s delay	2.2	2.4	2.9	-1.7	1.7	-1.4	-1.7	1.6	1.3
Delay disc. indifference point, 16s delay	0.4	0.4	0.9	-0.9	0.7	-0.9	-0.5	0.4	-0.0
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	0.3	-0.4	0.1	0.5	-0.5	-0.6
Delay disc. indifference point, 24s delay	0.9	0.9	1.1	0.9	-1.0	0.9	1.0	-1.0	-0.8
Delay disc. indifference point, 4s delay	0.5	0.5	0.7	-0.8	0.8	-0.7	-0.7	0.7	0.5
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.0	-0.0	-0.1
Indifference point function ln k	6.0	8.4	13.3	3.6	-3.1	3.4	2.8	-2.5	-1.3
Indifference point function log k	6.0	8.4	13.3	3.6	-3.1	3.4	2.8	-2.5	-1.3
Patch foraging total patch changes 0 sec	1.0	1.7	2.8	1.5	-1.5	1.7	1.1	-1.2	-0.7
Patch foraging total patch changes 12 sec	1.1	1.4	2.4	-1.5	1.2	-1.3	-1.3	1.0	0.6
Patch foraging total patch changes 18 sec	0.5	0.6	1.1	-1.1	0.8	-0.6	-0.9	0.6	0.4
Patch foraging total patch changes 24 sec	0.3	0.4	1.1	-1.1	0.5	-0.8	-0.5	0.2	-0.2
Patch foraging total patch changes 6 sec	1.1	1.6	3.9	-2.0	1.2	-1.4	-1.3	0.8	0.2
Patch foraging time to switch 0 sec	1.7	2.6	3.1	-1.6	1.8	-1.5	-1.8	1.7	1.4
Patch foraging water rate 0 sec	0.8	1.3	1.8	1.1	-1.2	0.8	1.4	-1.2	-1.1
Patch foraging water rate 12 sec	0.3	0.4	0.9	-0.2	0.6	-0.2	-0.6	0.8	1.0
Patch foraging water rate 18 sec	0.4	0.6	1.5	1.1	-0.6	1.2	0.3	-0.1	0.5
Patch foraging water rate 24 sec	0.1	0.1	0.4	-0.0	0.3	-0.6	0.1	0.2	0.1
Patch foraging water rate 6 sec	0.3	0.4	0.9	0.8	-0.6	0.3	0.9	-0.6	-0.5
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.0	0.4	-0.8	0.5	0.8	-0.9	-1.0
Distance traveled before self-admin	0.5	0.5	1.2	-1.1	0.5	-1.1	-0.3	0.1	-0.4
Distance traveled after self-admin	6.8	7.6	9.9	-3.1	3.0	-3.0	-2.8	2.6	1.7
Extensor digitorum longus weight	3.9	15.2	18.1	-3.9	4.3	-3.4	-4.2	4.1	3.5
Bone: elastic displacement	0.3	0.3	0.8	0.1	-0.4	-0.1	0.7	-0.6	-0.9
Bone: elastic work	1.2	1.6	2.5	0.8	-1.3	0.6	1.5	-1.5	-1.6
Bone: endosteal estimation	3.1	6.8	9.8	-3.1	2.8	-3.1	-2.5	2.3	1.4
Bone: endosteal perimeter	3.4	7.0	9.6	-3.1	2.9	-3.0	-2.6	2.4	1.5
Epididymis fat weight	3.8	8.8	12.2	-2.5	3.1	-1.7	-3.5	3.3	3.3
Delta time in closed arm before/after self-admin	1.0	1.0	1.8	-1.3	1.0	-0.8	-1.1	0.9	0.6
Delta time in open arm before/after self-admin	0.9	0.9	1.0	-0.9	1.0	-0.8	-1.0	1.0	0.9
Diff in mean of infusions in LGA sessions	0.3	0.3	0.8	0.7	-0.3	0.9	-0.1	0.1	0.6
Delay discount exponential model param	0.0	0.0	0.1	-0.0	0.2	-0.0	-0.2	0.3	0.4
Extinction: sum of active levers before priming	1.2	1.2	2.7	-0.5	0.9	0.1	-1.4	1.3	1.6
Active lever presses in extinction session 6	1.4	1.3	2.1	-1.0	1.1	-0.5	-1.5	1.3	1.3
Bone: final force	0.6	1.0	1.2	-1.1	1.1	-1.0	-1.1	1.0	0.7
Bone: final moment	0.6	1.0	1.4	-1.2	1.1	-1.1	-1.0	1.0	0.6
Food consumed during 24 hour testing period	0.5	0.7	1.2	1.1	-0.9	1.0	0.7	-0.6	-0.2
Glucose	0.6	1.0	2.9	-0.5	-0.4	-0.9	0.9	-1.0	-1.7
Heart weight	1.1	1.5	2.2	-1.3	1.3	-0.8	-1.5	1.3	1.1
Delay discount hyperbolic model param	0.0	0.0	0.1	0.1	0.1	0.1	-0.1	0.2	0.3
Intermittent access intake day 1-15 change	0.9	0.9	2.5	-1.3	0.9	-1.6	-0.4	0.4	-0.3
Intermittent access intake escalation	0.8	0.8	2.2	-1.2	0.7	-1.5	-0.2	0.2	-0.5
Intermittent access intake escalation 2	0.5	0.5	1.3	-0.5	-0.0	-0.9	0.7	-0.5	-1.2
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.9	0.0	-0.2	-0.6	0.5	-0.5	-0.9
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.4	0.6	-0.5	0.6	0.4	-0.3	-0.1
Intermitt. access escalation Index	0.8	0.7	1.9	0.1	0.5	0.3	-0.9	0.9	1.4
Intermittent access day 1 total infusions	2.4	2.8	3.2	-1.6	1.8	-1.6	-1.8	1.7	1.4
Intermittent access day 15 total infusions	5.1	5.7	9.6	-2.8	2.6	-3.1	-2.1	2.1	1.1
Intermittent access terminal intake (last 3 days)	4.5	4.9	6.0	-2.3	2.4	-2.4	-2.2	2.2	1.6
Intermittent access total infusions	2.9	3.2	5.1	-1.9	2.0	-2.3	-1.6	1.7	1.1
Intermittent access day 1 locomotion	2.4	2.5	4.0	-1.5	1.8	-2.0	-1.3	1.6	1.1
Intermittent access day 15 total locomotion	1.6	1.8	3.9	-1.6	1.4	-2.0	-1.0	1.0	0.3
Intermittent access total locomotion	1.1	1.2	2.9	-0.9	1.3	-1.7	-0.7	1.1	0.6
Intermittent access standard deviation	3.7	3.9	9.2	-2.6	2.1	-3.0	-1.3	1.3	0.1
Left kidney weight	0.1	0.3	0.8	-0.9	0.6	-0.6	-0.5	0.3	-0.0
Right kidney weight	0.1	0.2	0.5	-0.7	0.4	-0.5	-0.4	0.2	-0.1
Cocaine induced anxiety	2.5	2.9	4.2	2.0	-1.7	1.2	2.0	-1.7	-1.5
Post-drug Anxiety	0.9	1.0	1.6	1.3	-1.1	1.1	1.0	-0.9	-0.6
Baseline Anxiety	1.1	1.1	1.9	-1.3	1.0	-0.6	-1.4	1.0	0.9
Tail length	1.1	3.2	8.8	-0.1	1.2	0.6	-2.0	2.1	3.0
Length with tail	0.5	1.7	5.0	0.5	0.5	1.2	-1.2	1.3	2.2
Length without tail	0.4	0.9	2.7	0.0	0.6	0.6	-1.0	1.1	1.6
Times rat made contact with spout	1.3	1.5	1.9	1.4	-1.4	1.4	1.2	-1.2	-0.8
Lifetime Intake	4.3	4.8	7.0	-2.3	2.4	-2.6	-2.0	2.1	1.4
Liver weight, left	0.1	0.2	0.5	0.6	-0.1	0.7	-0.2	0.2	0.7
Liver weight, right	0.8	1.3	2.2	-0.6	1.1	-0.4	-1.3	1.3	1.5
Locomotor activity	0.7	1.1	1.3	-1.0	1.2	-1.0	-1.1	1.1	0.9
Locomotor testing distance	3.3	5.5	6.7	-2.5	2.6	-2.5	-2.3	2.3	1.7
Locomotor testing rearing	3.8	5.8	8.3	-2.9	2.6	-2.7	-2.4	2.2	1.4
Locomotion in novel chamber	0.9	1.1	3.9	-1.2	0.6	-2.0	0.1	-0.1	-1.1
Locomotion in novel chamber post-restriction	0.3	0.4	0.5	0.6	-0.6	0.3	0.6	-0.7	-0.7
Fecal boli incidents, locomotor time 1	0.4	0.4	0.5	0.7	-0.7	0.7	0.5	-0.6	-0.5
Change in fecal boli incidents, locomotor task	0.7	0.6	0.9	0.9	-0.9	0.7	0.9	-0.8	-0.6
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.6	0.8	-0.7	0.7	0.6	-0.6	-0.4
Bouts of movement, locomotor time 1	0.7	0.8	1.4	1.2	-0.9	1.1	0.8	-0.7	-0.3
Total resting periods, locomotor time 1	2.0	2.2	3.3	1.8	-1.6	1.7	1.5	-1.3	-0.8
Rest time, locomotor task time 1	0.6	0.7	0.9	0.7	-0.9	0.5	1.0	-0.9	-0.9
Distance moved, locomotor task time 1	1.2	1.3	1.6	-1.3	1.3	-1.0	-1.2	1.2	0.9
Vertical activity count, locomotor time 1	1.2	1.3	1.6	-1.1	1.2	-1.0	-1.3	1.2	1.1
Time >=10cm from walls, locomotor time 2	0.9	0.9	1.1	1.0	-1.0	0.9	1.0	-1.0	-0.7
Bouts of movement, locomotor time 2	1.4	1.5	2.2	1.5	-1.3	1.3	1.2	-1.1	-0.8
Total resting periods, locomotor time 2	0.9	1.0	1.6	1.3	-1.1	1.1	1.0	-0.9	-0.5
Rest time, locomotor task time 2	1.1	1.3	1.8	1.1	-1.2	1.0	1.3	-1.2	-1.0
Distance moved, locomotor task time 2	2.0	2.4	3.5	-1.9	1.7	-1.7	-1.5	1.4	0.8
Vertical activity count, locomotor time 2	0.8	0.8	1.0	-1.0	1.0	-0.9	-1.0	0.9	0.7
Light reinforcement 1	1.4	2.6	3.1	-1.8	1.7	-1.6	-1.7	1.6	1.2
Light reinforcement 2	0.1	0.2	0.3	-0.5	0.4	-0.6	-0.3	0.2	-0.0
Bone: marrow area	3.1	6.7	9.6	-3.1	2.8	-3.0	-2.5	2.3	1.4
Bone: maximum diameter	0.7	1.2	2.6	-1.5	1.1	-1.6	-0.9	0.7	0.1
Bone: maximum force	0.7	1.1	1.5	-1.2	1.2	-1.2	-1.1	1.0	0.7
Bone: maximum moment	0.8	1.3	1.9	-1.4	1.2	-1.4	-1.1	1.0	0.6
Mean time between licks in bursts	1.6	2.2	3.0	-1.1	1.5	-0.9	-1.7	1.7	1.7
Mean num. licks in bursts	0.1	0.1	0.2	0.3	-0.2	0.5	0.0	-0.0	0.2
Cd content in liver	1.3	1.4	1.7	-1.1	1.3	-0.9	-1.3	1.3	1.2
Co content in liver	0.2	0.3	0.3	-0.5	0.5	-0.3	-0.5	0.6	0.6
Cu content in liver	2.9	3.5	4.4	2.1	-2.0	2.0	1.8	-1.8	-1.2
Fe content in liver	0.2	0.2	0.7	0.5	-0.1	0.8	-0.2	0.2	0.6
K content in liver	0.2	0.2	0.4	0.4	-0.0	0.6	-0.3	0.2	0.6
Mg content in liver	0.0	0.0	0.0	-0.1	0.0	-0.2	0.0	-0.1	-0.2
Mn content in liver	1.5	1.7	2.7	1.6	-1.4	1.6	1.2	-1.1	-0.6
Na content in liver	0.1	0.1	0.2	-0.4	0.1	-0.5	-0.0	-0.1	-0.3
Rb content in liver	0.8	1.0	1.3	-1.1	1.1	-1.1	-1.1	1.0	0.7
Se content in liver	1.1	1.3	1.8	1.0	-1.2	0.7	1.3	-1.3	-1.3
Sr content in liver	1.9	1.8	2.2	-1.3	1.4	-1.1	-1.3	1.5	1.3
Zn content in liver	0.2	0.2	0.3	0.3	-0.5	0.2	0.5	-0.5	-0.5
Bone: minimum diameter	2.1	3.9	5.2	-2.3	2.1	-2.2	-1.9	1.9	1.2
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.5	0.3	-0.6	-0.1	0.1	-0.2
Time in novel zone, hab. session 1	0.3	0.3	0.6	0.7	-0.5	0.8	0.4	-0.3	-0.0
Total zone transitions, hab. session 1	4.9	6.9	8.9	-3.0	2.9	-2.8	-2.7	2.6	1.8
Total locomotion distance, hab. session 1	0.3	0.5	0.6	-0.7	0.7	-0.6	-0.7	0.7	0.6
Locomotion velocity, hab. session 1	0.4	0.6	0.7	-0.8	0.9	-0.8	-0.8	0.8	0.6
Time in familiar zone, hab. session 2	0.1	0.2	0.4	0.5	-0.4	0.6	0.2	-0.2	0.1
Time in novel zone, hab. session 2	0.3	0.3	0.6	0.3	-0.5	0.1	0.7	-0.6	-0.8
Total zone transitions, hab. session 2	2.6	3.4	4.2	-1.8	2.0	-1.5	-2.1	1.9	1.7
Total locomotion distance, hab. session 2	0.5	0.6	0.8	-0.8	0.8	-0.6	-0.9	0.8	0.7
Locomotion velocity, hab. session 2	0.5	0.7	0.9	-0.9	0.9	-0.7	-0.9	0.9	0.7
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.3	0.2	-0.5	-0.0	0.0	-0.2
Novelty place preference	0.0	0.0	0.0	-0.1	0.0	-0.1	0.0	-0.0	-0.1
Time in novel zone, NPP test	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1
Total zone transitions, NPP test	3.3	4.7	5.5	-2.4	2.4	-2.0	-2.3	2.2	1.7
Total locomotion distance, NPP test	0.2	0.3	0.7	-0.8	0.6	-0.8	-0.4	0.3	-0.0
Locomotion velocity, NPP test	0.2	0.3	0.7	-0.8	0.3	-0.8	-0.1	-0.0	-0.5
Intraocular pressure	1.1	1.6	3.2	-1.8	1.3	-1.8	-0.9	0.8	0.0
Delta distance traveled before/after self-admin	4.1	4.4	5.6	-1.8	2.3	-1.6	-2.2	2.4	2.2
Delta ambulatory time before/after self-admin	2.5	2.7	3.7	-1.3	1.8	-1.3	-1.7	1.9	1.8
Parametrial fat weight	11.2	21.8	30.1	-3.7	4.8	-2.7	-5.2	5.4	5.5
Pavlov. Cond. lever latency	2.3	3.0	4.6	-2.0	1.9	-2.1	-1.5	1.5	0.9
Pavlov. Cond. magazine entry latency	3.4	4.3	7.8	2.6	-2.2	2.8	1.7	-1.7	-0.8
Pavlov. Cond. change in total contacts	2.6	2.8	3.3	1.7	-1.8	1.6	1.7	-1.7	-1.4
Pavlov. Cond. index score	2.3	2.9	5.6	2.2	-1.8	2.4	1.3	-1.3	-0.5
Pavlov. Cond. latency score	2.5	3.1	6.4	2.3	-1.9	2.5	1.4	-1.3	-0.4
Pavlov. Cond. lever contacts	1.7	2.0	3.5	1.7	-1.5	1.9	1.2	-1.2	-0.6
Pavlov. Cond. magazine entry number	1.9	2.4	3.7	-1.8	1.7	-1.9	-1.4	1.4	0.8
Pavlov. Cond. intertrial magazine entries	3.2	3.8	5.4	-2.3	2.1	-2.3	-1.8	1.8	1.1
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.7	5.1	2.1	-1.8	2.3	1.4	-1.3	-0.6
Pavlov. Cond. response bias	2.2	2.7	4.6	2.0	-1.8	2.2	1.4	-1.4	-0.7
Pavlov. Cond. lever latency	1.7	2.3	3.6	-1.1	1.5	-0.5	-1.8	1.8	1.9
Pavlov. Cond. magazine entry latency	1.1	1.2	1.7	1.1	-1.2	0.7	1.3	-1.2	-1.1
Pavlov. Cond. change in total contacts	0.8	1.1	1.5	0.9	-1.1	0.6	1.2	-1.2	-1.1
Pavlov. Cond. index score	1.0	1.3	2.7	0.6	-1.0	0.0	1.4	-1.4	-1.6
Pavlov. Cond. latency score	1.2	1.5	3.2	0.5	-1.0	-0.1	1.5	-1.4	-1.8
Pavlov. Cond. lever contacts	0.5	0.7	1.3	0.5	-0.8	0.1	1.0	-1.0	-1.1
Pavlov. Cond. magazine entry number	0.7	0.9	1.3	-0.7	0.9	-0.3	-1.1	1.1	1.1
Pavlov. Cond. intertrial magazine entries	0.9	1.2	1.6	-0.8	1.2	-0.6	-1.2	1.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	2.7	0.6	-1.1	0.1	1.4	-1.4	-1.6
Pavlov. Cond. response bias	0.9	1.2	1.8	0.8	-1.1	0.4	1.3	-1.3	-1.3
Time in closed arm before self-admin	0.6	0.7	1.7	1.3	-0.7	1.2	0.4	-0.2	0.5
Time in closed arm after self-admin	0.1	0.1	0.1	0.4	-0.2	0.2	0.2	-0.2	-0.1
Time in open arm before self-admin	0.9	0.9	2.4	0.2	-0.8	0.1	1.1	-1.2	-1.5
Time in open arm after self-admin	0.7	0.7	1.7	-1.3	0.8	-1.3	-0.4	0.3	-0.4
Bone: periosteal estimation	1.4	2.9	4.8	-2.2	1.8	-2.2	-1.5	1.4	0.6
Bone: periosteal perimeter	0.9	1.5	2.5	-1.6	1.3	-1.6	-1.1	1.0	0.4
Bone: post-yield work	0.4	0.6	1.2	-0.3	0.7	-0.1	-0.9	0.9	1.1
Progressive ratio test 1 active lever presses	1.7	1.7	2.2	-1.2	1.4	-0.9	-1.5	1.5	1.4
Progressive ratio test 1 breakpoint	2.3	2.4	3.3	-1.3	1.6	-0.9	-1.8	1.7	1.7
Progressive ratio test 1 inactive lever presses	1.5	1.6	2.6	-1.3	1.4	-1.6	-1.0	1.2	0.8
Progressive ratio test 2 active lever presses	1.0	1.1	1.3	-0.9	1.1	-1.0	-1.1	1.1	0.9
Progressive ratio test 2 breakpoint	0.5	0.6	0.7	-0.6	0.8	-0.8	-0.8	0.8	0.7
Progressive ratio test 2 inactive lever presses	2.3	2.6	3.5	-1.7	1.8	-1.9	-1.5	1.6	1.2
Incentive Sensitization - Responses	0.2	0.2	0.2	-0.2	0.4	-0.5	-0.4	0.4	0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.2	0.4	-0.5	-0.4	0.4	0.4
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.5	0.4	0.1	1.0	-0.6	0.6	1.2
Progressive ratio	0.7	0.8	1.7	-1.3	0.9	-1.0	-0.9	0.7	0.3
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.1	-0.4	0.4	0.3	-0.4	-0.4
Seeking ratio, punishment vs. effort	1.1	1.4	2.2	1.5	-1.3	1.3	1.2	-1.1	-0.7
Retroperitoneal fat weight	0.2	0.6	1.2	-1.0	0.8	-1.1	-0.6	0.5	0.1
Reaction time number correct	0.1	0.1	0.2	0.3	0.1	-0.0	-0.1	0.3	0.5
Reaction time mean minus median	0.5	0.7	1.4	0.4	-0.8	0.4	0.9	-1.0	-1.2
Reaction time mean minus median AUC	0.1	0.1	0.3	0.0	-0.3	0.1	0.4	-0.5	-0.6
Reaction time num false alarms	1.2	1.6	2.0	1.1	-1.4	1.0	1.4	-1.4	-1.3
Reaction time num false alarms AUC	0.9	1.3	1.7	0.9	-1.2	0.8	1.2	-1.3	-1.3
Reaction time trials correct on left	0.1	0.1	0.2	0.3	0.1	-0.0	-0.1	0.3	0.5
Reaction time trials on left	0.0	0.1	0.2	0.3	0.2	-0.1	-0.1	0.3	0.4
Reaction time mean	0.2	0.3	0.5	0.2	-0.6	0.3	0.6	-0.7	-0.7
Reaction time mean AUC	0.5	0.7	1.2	0.4	-0.8	0.3	0.9	-1.0	-1.1
Median of all reaction times	0.1	0.1	0.2	0.0	-0.3	0.0	0.3	-0.4	-0.4
Reaction time omissions	0.3	0.5	0.8	-0.9	0.8	-0.8	-0.6	0.6	0.3
Reaction time false alarm rate	0.7	1.0	1.5	0.7	-1.1	0.7	1.0	-1.2	-1.2
Reaction time premature initiation rate	1.6	2.1	3.6	1.9	-1.6	1.8	1.3	-1.2	-0.5
Reaction time premature initiations	1.2	1.6	3.4	1.8	-1.3	1.6	1.1	-0.9	-0.2
Std. dev. reaction times	1.2	1.7	2.4	0.9	-1.4	0.8	1.4	-1.5	-1.5
Reaction time trials completed	0.0	0.1	0.2	0.3	0.2	-0.1	-0.1	0.3	0.4
Reaction time trials AUC	0.0	0.1	0.2	0.3	0.1	-0.0	-0.1	0.3	0.4
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.4	-0.3	0.0	0.5	-0.4	-0.4
Run reversals in cocaine runway, males	1.7	1.7	3.2	-1.7	1.4	-1.8	-1.0	0.9	0.2
Latency to leave start box in cocaine runway	0.1	0.1	0.4	0.1	-0.3	0.6	0.2	-0.2	-0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.9	0.2	-0.3	1.0	-0.0	-0.1	0.3
Latency to leave start box in cocaine runway, M	0.2	0.2	0.2	-0.5	0.5	-0.4	-0.4	0.5	0.3
Std. dev. time between licks in bursts	0.5	0.6	0.8	-0.6	0.8	-0.5	-0.9	0.9	0.9
Total sessions with >9 infusions	3.0	3.3	4.0	-1.9	2.0	-1.7	-1.9	1.9	1.5
Short access day 1 total inactive lever presses	0.2	0.2	0.3	-0.3	0.5	-0.5	-0.4	0.5	0.3
Short access day 10 total inactive lever presses	0.1	0.2	0.3	0.6	-0.4	0.3	0.4	-0.3	-0.2
Short access day 1 total infusions	3.4	3.6	6.1	-2.4	2.1	-2.5	-1.6	1.6	0.7
Short access day 10 total infusions	1.9	2.1	2.7	-1.5	1.6	-1.6	-1.5	1.5	1.1
Short access total infusions	4.4	5.0	7.5	-2.5	2.5	-2.7	-2.0	2.1	1.2
Short access day 1 locomotion	1.1	1.2	2.3	-1.5	1.1	-1.5	-0.8	0.7	0.1
Short access day 10 total locomotion	0.7	0.8	2.3	-0.8	1.0	-1.5	-0.3	0.7	0.2
Short access total locomotion	0.8	0.8	2.1	-1.0	1.0	-1.4	-0.6	0.7	0.2
One hour access (0.3 mA shock)	1.7	2.0	2.5	-1.5	1.6	-1.5	-1.4	1.4	1.0
Compulsive drug intake	1.4	1.4	3.0	1.7	-1.1	1.4	1.0	-0.8	-0.3
One hour access (shock baseline)	2.8	3.2	4.5	-2.1	1.9	-2.0	-1.7	1.7	1.1
Social response proportion	1.4	1.6	3.8	1.9	-0.9	1.9	0.5	-0.1	0.9
Social responses	1.6	2.1	3.9	-0.9	1.4	-0.5	-1.7	1.7	2.0
Social time	1.0	1.3	2.9	-0.4	1.0	-0.1	-1.3	1.4	1.7
Soleus weight	2.2	6.4	13.2	-1.1	2.3	-0.3	-3.0	3.1	3.6
Bone: stiffness	1.9	3.0	4.8	-1.1	1.7	-0.7	-2.0	2.0	2.2
Tibialis anterior weight	3.8	12.9	16.7	-3.0	3.8	-2.2	-4.1	4.1	4.0
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.0	0.4	0.1	0.7	-0.6	0.5	1.0
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	-0.3	0.4	-0.3	-0.3	0.3	0.3
Time to tail flick, test, before self-admin	4.1	4.0	6.4	2.5	-2.2	2.3	1.9	-1.7	-0.9
Time to tail flick, test, after self-admin	0.9	0.9	1.7	1.2	-1.0	1.3	0.9	-0.8	-0.4
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.7	-1.1	0.7	-1.3	-0.1	0.2	-0.4
Delta time to tail flick, test, before/after SA	1.7	1.5	2.7	-1.6	1.3	-1.4	-1.2	1.0	0.5
Tibia length	0.5	1.4	4.1	1.6	-1.0	2.0	0.4	-0.4	0.5
Ambulatory time before self-admin	0.2	0.2	0.4	-0.6	0.2	-0.6	-0.1	-0.1	-0.5
Ambulatory time after self-admin	3.4	3.7	4.4	-1.9	2.1	-1.7	-2.1	2.0	1.7
Bone: tissue strength	0.1	0.1	0.3	-0.4	0.1	-0.6	0.1	-0.1	-0.4
Total heroin consumption	0.8	1.0	2.6	0.7	0.1	1.2	-0.8	0.8	1.6
Bone: trabecular number	0.3	0.4	1.1	0.8	-0.3	1.0	-0.1	0.2	0.8
Bone: trabecular spacing	0.2	0.2	0.7	-0.6	0.3	-0.8	0.0	-0.0	-0.4
Bone: trabecular thickness	0.1	0.2	0.4	-0.1	0.3	-0.0	-0.5	0.5	0.6
Bone: trabecular tissue density	1.6	2.3	3.8	1.0	-1.5	0.7	1.7	-1.8	-1.9
Water consumed over 24 hours	3.8	4.6	6.9	2.6	-2.4	2.5	2.0	-1.9	-1.0
Number of responses in last shaping day	0.4	0.4	1.1	-0.9	0.6	-1.0	0.0	0.2	-0.3