Hub : Genes

Socs7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Socs7 0.05 0.03 9.0e-05 0.02 0.02 0.01 0.01 4.6e-03 1.0e-03 1.0e-02 9.7e-03
2 Brain gene expression Socs7 0.05 0.04 7.6e-05 0.06 0.05 0.06 0.06 3.3e-06 2.0e-05 2.6e-06 3.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.52.52.7-1.61.5
Area under the delay curve1.61.92.6-1.61.1
BMI with tail1.65.410.83.30.2
BMI without tail0.92.74.42.1-1.0
Body weight4.218.228.65.3-2.8
Weight adjusted by age0.20.40.60.3-0.8
Bone surface0.10.10.20.2-0.4
Bone volume0.00.00.0-0.10.1
Breakpoint value in progressive ratio session2.53.04.41.2-2.1
Number of licking bursts0.20.30.6-0.70.3
Context. condit. distance diff. score0.30.30.50.7-0.3
Locomotion velocity, session 11.11.21.81.3-0.7
Locomotion distance, session 12.43.03.81.9-1.5
Locomotion velocity, session 20.50.60.60.8-0.7
Locomotion distance, session 20.40.60.70.8-0.7
Locomotion velocity, session 30.10.10.10.3-0.2
Locomotion distance, session 30.20.20.20.4-0.5
Stereotopy head waving bouts, day 32.42.83.7-1.91.4
Stereotopy head waving duration, day 30.40.40.5-0.70.6
Locomotion velocity, session 70.30.40.40.6-0.5
Locomotion distance, session 70.00.00.1-0.30.0
Stereotopy head waving bouts, day 70.40.40.9-0.9-0.2
Stereotopy head waving duration, day 70.30.40.7-0.3-0.8
Locomotion velocity, session 84.85.78.22.9-1.8
Locomotion distance, session 81.11.62.01.4-1.1
Degree of sensitization distance0.10.10.10.3-0.1
Degree of sensitization stereotypy0.70.71.5-1.2-0.1
Conditioned locomotion0.60.71.0-0.61.0
Cocaine response after cond. corrected2.02.42.9-1.31.7
Cocaine response after cond. not corrected2.93.53.8-2.01.8
Cocaine response before conditioning0.91.12.1-1.5-0.0
Saline control response0.10.10.2-0.40.1
Bone: connectivity density1.92.93.9-2.01.4
Bone: cortical apparent density2.53.56.9-2.60.3
Bone: cortical area0.40.70.8-0.70.9
Bone: cortical porosity2.22.43.8-1.01.9
Bone: cortical porosity2.83.04.9-1.12.2
Bone: cortical thickness1.42.33.1-1.81.2
Bone: cortical thickness5.56.58.1-2.82.2
Bone: cortical tissue density2.63.56.9-2.60.2
Condit. Reinf. active minus inactive responses0.20.20.4-0.60.2
Condit. Reinf. active-inactive response ratio0.80.80.9-0.91.0
Condit. Reinf. active responses0.20.30.5-0.70.2
Condit. Reinf. inactive responses0.20.30.5-0.70.2
Incentive salience index mean0.81.01.5-1.20.7
Condit. Reinf. lever presses0.81.21.7-1.30.8
Condit. Reinf. active minus inactive responses0.70.91.0-1.00.9
Condit. Reinf. active-inactive response ratio0.10.10.2-0.40.3
Condit. Reinf. active responses1.11.61.8-1.31.1
Condit. Reinf. inactive responses2.02.63.4-1.81.4
Condit. Reinf. lever presses0.00.00.1-0.2-0.1
Condit. Reinf. lever reinforcers received1.11.51.8-1.31.1
Conditioned reinforcement - actives1.01.71.8-1.31.3
Conditioned reinforcement - inactives0.71.01.8-0.31.3
Conditioned locomotion3.03.96.2-1.32.5
Patch foraging indifference point 0 sec1.42.62.9-1.51.7
Patch foraging indifference point AUC1.01.42.60.5-1.6
Delay disc. indifference point, 0s delay2.32.53.0-1.71.5
Delay disc. indifference point, 16s delay0.50.51.1-1.0-0.1
Delay disc. indifference point, 2s delay3.94.44.6-2.22.0
Delay disc. indifference point, 24s delay0.20.20.4-0.3-0.6
Delay disc. indifference point, 4s delay1.11.11.8-1.30.7
Delay disc. indifference point, 8s delay1.61.92.2-1.31.5
Indifference point function ln k0.50.81.5-0.41.2
Indifference point function log k0.50.81.5-0.41.2
Patch foraging total patch changes 0 sec0.91.82.2-1.21.5
Patch foraging total patch changes 12 sec2.63.34.7-2.21.4
Patch foraging total patch changes 18 sec0.10.10.2-0.0-0.5
Patch foraging total patch changes 24 sec0.40.71.1-1.00.6
Patch foraging total patch changes 6 sec0.30.40.8-0.90.2
Patch foraging time to switch 0 sec0.00.10.1-0.10.3
Patch foraging water rate 0 sec0.00.00.1-0.10.3
Patch foraging water rate 12 sec0.10.10.20.5-0.1
Patch foraging water rate 18 sec1.11.71.9-1.41.2
Patch foraging water rate 24 sec0.70.91.2-0.81.1
Patch foraging water rate 6 sec0.71.01.4-1.20.7
Seeking ratio, delayed vs. immediate footshock0.30.40.50.7-0.5
Distance traveled before self-admin0.10.20.30.20.6
Distance traveled after self-admin0.20.30.60.8-0.1
Extensor digitorum longus weight6.626.133.55.8-4.3
Bone: elastic displacement0.10.10.1-0.00.4
Bone: elastic work0.00.10.1-0.10.3
Bone: endosteal estimation1.02.33.92.0-0.8
Bone: endosteal perimeter1.22.54.42.1-0.7
Epididymis fat weight0.00.10.10.2-0.3
Delta time in closed arm before/after self-admin4.64.24.42.0-2.1
Delta time in open arm before/after self-admin0.00.00.0-0.2-0.0
Diff in mean of infusions in LGA sessions0.00.00.00.20.1
Delay discount exponential model param1.21.31.91.4-0.9
Extinction: sum of active levers before priming1.01.12.10.4-1.5
Active lever presses in extinction session 60.80.81.70.1-1.3
Bone: final force1.32.12.5-1.61.3
Bone: final moment1.52.52.6-1.51.6
Food consumed during 24 hour testing period1.31.82.41.1-1.6
Glucose0.81.31.4-1.21.1
Heart weight2.43.75.92.4-1.2
Delay discount hyperbolic model param1.21.31.81.3-0.9
Intermittent access intake day 1-15 change0.20.30.50.4-0.7
Intermittent access intake escalation0.20.40.70.4-0.9
Intermittent access intake escalation 21.71.92.61.1-1.6
Intermitt. access day 1 inactive lever presses0.10.50.8-0.90.4
Intermitt. access day 15 inactive lever presses0.10.20.3-0.50.3
Intermitt. access escalation Index0.71.01.31.2-0.8
Intermittent access day 1 total infusions0.10.10.2-0.20.4
Intermittent access day 15 total infusions0.10.10.20.2-0.4
Intermittent access terminal intake (last 3 days)0.20.20.4-0.1-0.7
Intermittent access total infusions0.00.00.10.1-0.2
Intermittent access day 1 locomotion0.40.50.6-0.60.8
Intermittent access day 15 total locomotion0.40.80.9-1.00.8
Intermittent access total locomotion1.72.02.4-1.31.6
Intermittent access standard deviation0.00.10.1-0.20.2
Left kidney weight0.52.23.81.9-0.8
Right kidney weight0.00.20.30.60.3
Cocaine induced anxiety2.94.15.22.3-1.7
Post-drug Anxiety0.60.71.11.1-0.4
Baseline Anxiety3.43.94.1-2.01.9
Tail length1.55.910.41.2-3.2
Length with tail2.912.814.03.4-3.7
Length without tail2.06.510.03.2-1.7
Times rat made contact with spout0.40.40.7-0.90.3
Lifetime Intake0.00.10.1-0.0-0.3
Liver weight, left0.30.50.80.5-0.9
Liver weight, right0.30.51.0-1.0-0.0
Locomotor activity0.20.30.5-0.70.4
Locomotor testing distance1.93.44.2-2.11.6
Locomotor testing rearing2.04.07.0-2.61.0
Locomotion in novel chamber1.62.13.7-1.90.6
Locomotion in novel chamber post-restriction0.00.00.1-0.10.3
Fecal boli incidents, locomotor time 10.30.50.80.9-0.3
Change in fecal boli incidents, locomotor task0.60.51.0-1.00.3
Time >=10cm from walls, locomotor time 10.70.70.8-0.90.8
Bouts of movement, locomotor time 10.20.20.20.50.4
Total resting periods, locomotor time 10.20.20.30.60.3
Rest time, locomotor task time 10.40.40.90.20.9
Distance moved, locomotor task time 10.20.30.4-0.6-0.4
Vertical activity count, locomotor time 10.00.00.00.1-0.2
Time >=10cm from walls, locomotor time 22.73.95.5-1.52.3
Bouts of movement, locomotor time 20.60.91.7-0.41.3
Total resting periods, locomotor time 20.50.81.6-0.11.3
Rest time, locomotor task time 20.70.91.51.2-0.6
Distance moved, locomotor task time 20.10.10.1-0.3-0.4
Vertical activity count, locomotor time 20.30.40.8-0.30.9
Light reinforcement 11.33.24.0-1.52.0
Light reinforcement 20.50.80.8-0.90.9
Bone: marrow area1.02.23.71.9-0.8
Bone: maximum diameter0.10.10.30.10.5
Bone: maximum force0.30.50.8-0.40.9
Bone: maximum moment0.50.81.5-0.31.2
Mean time between licks in bursts0.71.72.91.7-0.7
Mean num. licks in bursts0.00.00.0-0.10.2
Cd content in liver0.80.91.11.1-0.8
Co content in liver1.61.92.41.5-1.2
Cu content in liver1.11.31.31.1-1.1
Fe content in liver1.51.82.51.6-1.1
K content in liver0.10.10.2-0.00.5
Mg content in liver0.10.10.1-0.4-0.3
Mn content in liver0.20.20.3-0.2-0.6
Na content in liver0.10.10.3-0.00.5
Rb content in liver0.70.81.4-1.20.4
Se content in liver2.53.03.1-1.81.7
Sr content in liver0.80.70.90.7-1.0
Zn content in liver2.22.42.9-1.41.7
Bone: minimum diameter0.10.20.50.7-0.1
Time in familiar zone, hab. session 10.40.40.4-0.6-0.6
Time in novel zone, hab. session 11.81.83.1-0.71.8
Total zone transitions, hab. session 12.33.24.31.5-2.1
Total locomotion distance, hab. session 10.10.20.3-0.1-0.5
Locomotion velocity, hab. session 10.40.60.90.5-1.0
Time in familiar zone, hab. session 20.30.40.4-0.60.6
Time in novel zone, hab. session 20.10.20.2-0.30.4
Total zone transitions, hab. session 20.40.60.60.7-0.8
Total locomotion distance, hab. session 20.00.00.00.2-0.1
Locomotion velocity, hab. session 20.10.10.10.4-0.2
Novel to familiar place preference ratio1.41.51.91.0-1.4
Novelty place preference0.80.81.20.7-1.1
Time in novel zone, NPP test0.20.20.40.2-0.6
Total zone transitions, NPP test0.20.20.40.3-0.6
Total locomotion distance, NPP test0.00.00.0-0.20.2
Locomotion velocity, NPP test0.10.20.20.4-0.5
Intraocular pressure1.52.13.01.1-1.7
Delta distance traveled before/after self-admin0.30.40.70.8-0.3
Delta ambulatory time before/after self-admin0.10.10.20.4-0.1
Parametrial fat weight0.92.22.6-1.41.6
Pavlov. Cond. lever latency1.51.93.51.9-0.5
Pavlov. Cond. magazine entry latency6.27.911.8-3.42.0
Pavlov. Cond. change in total contacts4.64.99.4-3.10.6
Pavlov. Cond. index score5.57.011.5-3.41.6
Pavlov. Cond. latency score4.15.29.0-3.01.2
Pavlov. Cond. lever contacts1.82.24.0-2.00.6
Pavlov. Cond. magazine entry number8.110.216.64.1-1.9
Pavlov. Cond. intertrial magazine entries0.91.01.51.2-0.8
Pavlov. Cond. lever-magazine prob. diff.6.78.213.4-3.71.8
Pavlov. Cond. response bias6.37.712.5-3.51.7
Pavlov. Cond. lever latency0.20.20.20.5-0.5
Pavlov. Cond. magazine entry latency0.00.00.00.00.1
Pavlov. Cond. change in total contacts0.50.71.0-0.71.0
Pavlov. Cond. index score0.20.20.3-0.40.5
Pavlov. Cond. latency score0.10.20.2-0.40.5
Pavlov. Cond. lever contacts0.30.40.4-0.70.6
Pavlov. Cond. magazine entry number0.60.71.10.6-1.0
Pavlov. Cond. intertrial magazine entries1.72.63.21.4-1.8
Pavlov. Cond. lever-magazine prob. diff.0.10.20.3-0.20.6
Pavlov. Cond. response bias0.71.01.3-0.91.1
Time in closed arm before self-admin1.92.53.1-1.41.8
Time in closed arm after self-admin0.30.30.50.7-0.4
Time in open arm before self-admin3.03.33.61.9-1.7
Time in open arm after self-admin0.70.81.20.7-1.1
Bone: periosteal estimation0.10.20.20.50.3
Bone: periosteal perimeter0.30.61.21.1-0.1
Bone: post-yield work0.30.40.70.80.4
Progressive ratio test 1 active lever presses0.70.91.2-1.10.7
Progressive ratio test 1 breakpoint0.70.91.2-1.10.7
Progressive ratio test 1 inactive lever presses0.30.40.6-0.40.8
Progressive ratio test 2 active lever presses0.30.30.6-0.80.2
Progressive ratio test 2 breakpoint0.30.40.7-0.90.2
Progressive ratio test 2 inactive lever presses0.10.20.20.4-0.5
Incentive Sensitization - Responses0.20.20.5-0.7-0.1
Incentive Sensitization - Breakpoint0.10.20.3-0.5-0.2
Sum of active levers in priming session hrs 5-60.90.81.3-0.6-1.2
Progressive ratio0.30.50.90.1-1.0
Food seeking constrained by brief footshock0.50.70.8-0.70.9
Seeking ratio, punishment vs. effort0.50.71.2-0.51.1
Retroperitoneal fat weight0.52.23.3-1.11.8
Reaction time number correct0.30.61.11.0-0.5
Reaction time mean minus median0.00.00.10.30.0
Reaction time mean minus median AUC0.10.30.3-0.50.6
Reaction time num false alarms0.40.61.0-1.00.3
Reaction time num false alarms AUC0.30.40.8-0.90.3
Reaction time trials correct on left0.30.61.11.0-0.5
Reaction time trials on left0.30.61.01.0-0.4
Reaction time mean0.00.00.10.30.1
Reaction time mean AUC0.00.10.10.30.1
Median of all reaction times0.00.00.00.00.2
Reaction time omissions0.40.60.7-0.80.7
Reaction time false alarm rate0.81.11.9-1.40.6
Reaction time premature initiation rate0.50.70.9-1.00.7
Reaction time premature initiations0.00.00.0-0.10.1
Std. dev. reaction times0.00.00.1-0.10.3
Reaction time trials completed0.30.61.01.0-0.4
Reaction time trials AUC0.30.50.90.9-0.4
Run reversals in cocaine runway, females0.40.40.80.9-0.2
Run reversals in cocaine runway, males0.30.30.5-0.00.7
Latency to leave start box in cocaine runway2.52.84.42.1-1.1
Latency to leave start box in cocaine runway, F2.63.05.12.3-0.9
Latency to leave start box in cocaine runway, M0.50.40.60.8-0.5
Std. dev. time between licks in bursts0.30.40.90.9-0.0
Total sessions with >9 infusions0.10.10.1-0.30.2
Short access day 1 total inactive lever presses0.71.01.9-1.4-0.2
Short access day 10 total inactive lever presses0.61.51.61.2-1.2
Short access day 1 total infusions0.00.00.0-0.2-0.2
Short access day 10 total infusions0.10.10.2-0.50.1
Short access total infusions0.00.00.1-0.0-0.3
Short access day 1 locomotion0.91.11.4-0.91.2
Short access day 10 total locomotion2.24.14.7-1.92.2
Short access total locomotion0.50.60.8-0.60.9
One hour access (0.3 mA shock)0.30.30.6-0.2-0.8
Compulsive drug intake0.40.50.6-0.8-0.7
One hour access (shock baseline)0.00.10.10.40.1
Social response proportion1.31.52.8-0.51.7
Social responses1.11.42.6-0.51.6
Social time0.00.00.10.30.1
Soleus weight0.51.41.4-1.21.1
Bone: stiffness0.30.50.8-0.40.9
Tibialis anterior weight1.34.44.62.1-2.1
Time to tail flick, vehicle, before self-admin0.90.91.1-0.9-1.1
Time to tail flick, vehicle, after self-admin0.10.10.20.1-0.5
Time to tail flick, test, before self-admin0.60.70.90.7-0.9
Time to tail flick, test, after self-admin0.00.00.0-0.2-0.2
Delta time to tail flick, vehicle, before/after SA0.70.71.2-0.21.1
Delta time to tail flick, test, before/after SA2.12.22.4-1.61.4
Tibia length0.41.01.61.3-0.6
Ambulatory time before self-admin0.20.30.50.70.4
Ambulatory time after self-admin0.91.12.01.4-0.4
Bone: tissue strength0.60.60.70.8-0.8
Total heroin consumption0.40.50.6-0.6-0.8
Bone: trabecular number4.06.68.2-2.92.3
Bone: trabecular spacing0.70.91.41.2-0.7
Bone: trabecular thickness0.00.00.0-0.10.2
Bone: trabecular tissue density0.10.20.40.1-0.6
Water consumed over 24 hours0.00.00.10.1-0.3
Number of responses in last shaping day0.91.01.60.6-1.3