Snx13

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Snx13	0.05	0.03	2.4e-06	0.05	0.05	0.05	0.05	1.8e-06	6.8e-07	1.6e-06	1.1e-06
2	Adipose	gene expression	Snx13	0.02	0.02	7.3e-03	0	0.02	0.01	0.01	1.1e-01	6.4e-03	2.8e-02	5.3e-02
3	PL	alternative polyA	XM_006240022.4	0.03	0.02	5.1e-03	0	0.01	0.01	0	1.5e-01	1.7e-02	6.8e-02	8.2e-02
4	PL	alternative polyA	NM_001399695.1	0.03	0.02	5.7e-03	0	0.01	0	0	9.6e-02	2.0e-02	8.0e-02	9.2e-02
5	Adipose	mRNA stability	Snx13	0.03	0.02	3.9e-03	0	0	0	0	1.5e-01	2.5e-01	1.7e-01	1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	4.3	7.1	8.8	-2.8	-2.0	3.0	-2.9	-2.5
Area under the delay curve	0.2	0.2	0.5	0.0	0.1	-0.5	0.5	0.7
BMI with tail	2.6	8.4	10.1	2.4	3.2	-3.1	3.1	2.7
BMI without tail	2.4	4.9	6.4	1.8	2.5	-2.1	2.1	2.4
Body weight	0.1	0.5	1.3	0.2	1.1	-0.4	0.5	0.8
Weight adjusted by age	0.9	1.1	1.9	1.4	1.1	-0.7	0.7	1.1
Bone surface	3.7	6.5	8.7	-2.6	-1.7	3.0	-2.9	-2.3
Bone volume	4.6	7.8	10.4	-2.8	-2.1	3.2	-3.2	-2.5
Breakpoint value in progressive ratio session	0.4	0.4	0.7	-0.6	-0.4	0.8	-0.8	-0.6
Number of licking bursts	4.6	5.4	6.2	2.3	2.0	-2.5	2.5	2.2
Context. condit. distance diff. score	0.0	0.0	0.1	-0.3	-0.1	0.3	-0.3	-0.1
Locomotion velocity, session 1	1.1	1.2	1.7	-0.8	-1.1	1.1	-1.1	-1.3
Locomotion distance, session 1	0.1	0.1	0.3	-0.5	-0.4	0.1	-0.1	-0.3
Locomotion velocity, session 2	0.1	0.1	0.3	0.0	-0.0	-0.6	0.6	-0.0
Locomotion distance, session 2	0.6	0.8	1.6	-1.3	-1.0	0.7	-0.7	-0.9
Locomotion velocity, session 3	0.3	0.4	0.9	0.4	0.9	-0.3	0.4	0.7
Locomotion distance, session 3	0.8	0.9	2.7	-1.7	-0.5	0.8	-0.8	-0.5
Stereotopy head waving bouts, day 3	1.3	1.5	2.7	1.6	0.9	-1.2	1.2	1.1
Stereotopy head waving duration, day 3	0.6	0.7	2.2	1.5	0.0	-0.8	0.7	0.3
Locomotion velocity, session 7	1.8	1.9	3.1	-1.6	-1.8	1.1	-1.1	-1.2
Locomotion distance, session 7	5.0	6.3	6.7	-2.4	-2.6	2.5	-2.5	-2.5
Stereotopy head waving bouts, day 7	1.1	1.2	1.9	1.4	0.8	-1.0	1.0	1.3
Stereotopy head waving duration, day 7	0.9	1.1	2.4	1.5	0.8	-0.8	0.8	1.1
Locomotion velocity, session 8	0.3	0.3	0.5	-0.6	-0.6	0.4	-0.4	-0.7
Locomotion distance, session 8	0.7	1.0	2.4	-1.6	-1.0	0.7	-0.7	-0.6
Degree of sensitization distance	2.2	2.2	3.4	-0.8	-1.9	1.4	-1.4	-1.7
Degree of sensitization stereotypy	1.5	1.6	2.7	1.6	1.1	-1.1	1.1	1.4
Conditioned locomotion	0.1	0.2	0.3	0.4	0.4	0.5	-0.5	0.1
Cocaine response after cond. corrected	3.1	3.4	5.3	1.4	1.7	-1.9	1.9	2.3
Cocaine response after cond. not corrected	1.7	1.9	3.5	0.9	1.3	-1.3	1.3	1.9
Cocaine response before conditioning	1.7	2.0	2.3	-1.4	-1.3	1.5	-1.5	-1.3
Saline control response	7.1	9.2	10.5	-3.2	-3.0	3.0	-3.0	-2.8
Bone: connectivity density	2.0	3.1	4.3	-2.1	-0.8	2.1	-2.0	-1.6
Bone: cortical apparent density	0.1	0.1	0.2	0.4	-0.1	-0.3	0.3	-0.0
Bone: cortical area	0.1	0.2	0.4	-0.4	-0.6	0.3	-0.3	-0.3
Bone: cortical porosity	0.1	0.1	0.3	0.2	0.4	-0.2	0.2	0.6
Bone: cortical porosity	0.1	0.1	0.2	0.3	0.4	-0.1	0.1	0.5
Bone: cortical thickness	0.1	0.1	0.2	0.3	-0.1	-0.4	0.4	0.3
Bone: cortical thickness	4.3	5.0	5.6	2.2	2.0	-2.4	2.4	2.2
Bone: cortical tissue density	0.1	0.1	0.2	0.5	-0.1	-0.3	0.3	0.0
Condit. Reinf. active minus inactive responses	5.9	6.6	9.6	-3.1	-2.5	2.4	-2.4	-2.4
Condit. Reinf. active-inactive response ratio	4.8	5.2	6.6	-2.6	-2.3	2.1	-2.1	-2.3
Condit. Reinf. active responses	4.2	5.2	8.4	-2.9	-2.2	2.1	-2.1	-1.9
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	-0.0	-0.1	0.1	0.4
Incentive salience index mean	5.2	6.2	11.3	-3.4	-2.3	2.3	-2.3	-2.0
Condit. Reinf. lever presses	1.8	2.4	4.8	-2.2	-1.2	1.6	-1.5	-0.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.5	-0.2	-0.0	0.0	-0.2
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.9	0.9	0.8	-0.6	0.6	0.5
Condit. Reinf. active responses	1.3	1.8	3.8	-1.9	-1.5	1.0	-1.0	-1.1
Condit. Reinf. inactive responses	2.0	2.4	5.4	-2.3	-1.9	1.0	-1.0	-1.0
Condit. Reinf. lever presses	1.8	2.5	5.2	-2.3	-1.4	1.3	-1.3	-1.3
Condit. Reinf. lever reinforcers received	2.3	3.2	5.9	-2.4	-1.9	1.4	-1.4	-1.6
Conditioned reinforcement - actives	0.3	0.3	0.8	0.9	0.7	-0.1	0.1	0.3
Conditioned reinforcement - inactives	0.1	0.1	0.2	-0.4	-0.5	0.2	-0.2	0.1
Conditioned locomotion	0.1	0.1	0.2	0.4	0.3	0.5	-0.4	-0.1
Patch foraging indifference point 0 sec	0.4	0.6	1.7	-1.3	-0.9	0.4	-0.4	-0.5
Patch foraging indifference point AUC	0.8	1.0	2.6	-1.6	-0.6	0.7	-0.7	-1.0
Delay disc. indifference point, 0s delay	0.8	0.9	1.5	0.6	0.5	-1.2	1.2	1.0
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.3	0.2	-0.2	0.2	0.4
Delay disc. indifference point, 2s delay	0.5	0.5	0.7	0.8	0.5	-0.7	0.7	0.8
Delay disc. indifference point, 24s delay	0.6	0.5	1.3	0.2	0.8	-0.6	0.6	1.1
Delay disc. indifference point, 4s delay	0.7	0.8	1.5	0.1	0.3	-1.2	1.2	0.9
Delay disc. indifference point, 8s delay	0.4	0.4	0.9	-0.8	-1.0	0.5	-0.5	-0.2
Indifference point function ln k	1.3	1.8	2.6	1.5	1.2	-1.2	1.2	1.6
Indifference point function log k	1.3	1.8	2.6	1.5	1.2	-1.2	1.2	1.6
Patch foraging total patch changes 0 sec	0.3	0.4	1.3	-1.1	-0.7	0.2	-0.2	-0.4
Patch foraging total patch changes 12 sec	0.8	1.0	2.5	-1.6	-0.8	0.4	-0.4	-1.2
Patch foraging total patch changes 18 sec	0.9	1.1	2.6	-1.6	-1.0	0.7	-0.7	-1.0
Patch foraging total patch changes 24 sec	0.2	0.2	0.3	-0.6	-0.3	0.4	-0.4	-0.5
Patch foraging total patch changes 6 sec	0.6	0.8	2.7	-1.7	-1.0	-0.1	0.1	-0.6
Patch foraging time to switch 0 sec	0.2	0.3	0.8	0.9	-0.4	-0.5	0.5	0.2
Patch foraging water rate 0 sec	0.1	0.1	0.1	-0.4	0.4	0.3	-0.3	-0.3
Patch foraging water rate 12 sec	0.1	0.2	0.4	0.1	0.6	-0.3	0.3	0.6
Patch foraging water rate 18 sec	0.5	0.6	0.9	0.3	0.8	-0.8	0.9	1.0
Patch foraging water rate 24 sec	0.0	0.1	0.2	-0.5	0.2	0.0	-0.0	0.0
Patch foraging water rate 6 sec	0.2	0.3	0.8	0.5	0.9	-0.3	0.3	0.5
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	0.5	0.7	-0.3	0.3	0.4
Distance traveled before self-admin	0.7	0.7	1.1	-0.7	-0.3	1.0	-1.0	-1.0
Distance traveled after self-admin	4.4	4.9	6.4	-2.5	-1.7	2.2	-2.2	-2.4
Extensor digitorum longus weight	2.0	7.9	10.7	-3.0	-3.3	2.6	-2.6	-2.5
Bone: elastic displacement	3.1	3.5	4.2	1.5	2.1	-2.0	2.0	1.8
Bone: elastic work	1.5	1.9	2.4	0.8	1.5	-1.5	1.5	1.5
Bone: endosteal estimation	0.3	0.6	1.1	-1.0	-0.7	0.7	-0.7	-0.6
Bone: endosteal perimeter	0.7	1.4	1.4	-1.1	-1.2	1.2	-1.2	-1.2
Epididymis fat weight	1.5	3.6	4.2	1.7	2.1	-2.0	2.0	1.7
Delta time in closed arm before/after self-admin	1.9	1.9	2.5	1.6	1.5	-1.2	1.2	1.3
Delta time in open arm before/after self-admin	0.7	0.7	1.0	-0.9	-1.0	0.7	-0.7	-0.8
Diff in mean of infusions in LGA sessions	0.8	0.9	1.3	-0.6	-0.8	1.1	-1.1	-1.0
Delay discount exponential model param	0.3	0.3	0.7	-0.1	-0.2	0.6	-0.6	-0.8
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.4	0.3	-0.4	0.4	0.3
Active lever presses in extinction session 6	0.0	0.0	0.1	0.0	0.2	0.2	-0.2	-0.4
Bone: final force	0.0	0.1	0.2	0.5	-0.0	0.2	-0.1	0.2
Bone: final moment	0.0	0.0	0.1	0.3	-0.1	0.1	-0.1	0.2
Food consumed during 24 hour testing period	0.7	0.8	1.2	-0.7	-0.6	1.1	-1.1	-1.0
Glucose	0.5	0.8	1.1	0.5	0.8	-1.0	1.1	1.0
Heart weight	0.4	0.5	0.8	-0.8	-0.7	0.9	-0.8	-0.2
Delay discount hyperbolic model param	0.4	0.4	0.9	-0.2	-0.3	0.7	-0.7	-0.9
Intermittent access intake day 1-15 change	1.1	1.1	1.6	-1.3	-0.9	1.0	-1.0	-0.9
Intermittent access intake escalation	0.8	0.8	1.5	-1.2	-0.6	0.9	-0.8	-0.7
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.4	0.0	0.2	-0.1	0.2
Intermitt. access day 1 inactive lever presses	0.9	0.9	1.6	-0.2	-0.8	1.2	-1.3	-0.9
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.0	0.1
Intermitt. access escalation Index	0.1	0.1	0.3	-0.1	0.5	-0.3	0.3	0.3
Intermittent access day 1 total infusions	0.3	0.3	1.4	1.2	0.2	-0.1	0.1	0.5
Intermittent access day 15 total infusions	0.2	0.2	0.4	0.0	-0.3	0.6	-0.6	-0.1
Intermittent access terminal intake (last 3 days)	0.6	0.7	1.2	1.0	0.8	-0.5	0.5	1.1
Intermittent access total infusions	1.1	1.2	2.2	1.5	0.9	-0.8	0.8	1.3
Intermittent access day 1 locomotion	0.4	0.4	0.5	0.1	-0.7	0.7	-0.7	-0.5
Intermittent access day 15 total locomotion	0.3	0.3	0.7	-0.7	-0.8	0.3	-0.3	-0.4
Intermittent access total locomotion	0.2	0.3	0.5	-0.1	-0.5	0.7	-0.7	-0.3
Intermittent access standard deviation	0.0	0.0	0.1	0.1	0.2	-0.2	0.2	0.3
Left kidney weight	0.3	0.9	2.6	-1.6	-0.8	0.8	-0.7	-0.6
Right kidney weight	0.0	0.1	0.2	-0.5	0.3	0.1	-0.0	0.3
Cocaine induced anxiety	0.1	0.1	0.2	-0.2	-0.5	0.5	-0.5	-0.1
Post-drug Anxiety	0.2	0.2	0.2	-0.3	-0.5	0.5	-0.5	-0.3
Baseline Anxiety	0.3	0.4	0.5	-0.5	-0.7	0.6	-0.5	-0.7
Tail length	0.7	2.0	3.2	-1.4	-0.9	1.8	-1.7	-0.9
Length with tail	1.5	5.5	7.0	-2.4	-2.0	2.6	-2.6	-2.0
Length without tail	1.4	3.1	3.7	-1.6	-1.5	1.9	-1.9	-1.9
Times rat made contact with spout	0.2	0.2	0.6	0.5	0.8	0.0	-0.0	0.2
Lifetime Intake	1.3	1.5	2.2	1.5	0.9	-1.1	1.1	1.4
Liver weight, left	0.3	0.5	1.1	-0.1	-0.1	-1.1	1.0	0.3
Liver weight, right	0.7	1.1	2.1	0.8	1.4	-0.9	0.9	1.2
Locomotor activity	4.6	7.3	12.5	-3.5	-3.1	1.9	-1.9	-2.6
Locomotor testing distance	3.3	5.5	9.4	-3.1	-2.8	1.6	-1.6	-2.3
Locomotor testing rearing	4.7	7.3	9.4	-3.1	-2.8	2.3	-2.3	-2.9
Locomotion in novel chamber	0.1	0.1	0.3	0.5	0.3	0.0	-0.0	-0.1
Locomotion in novel chamber post-restriction	0.2	0.3	0.8	0.7	0.9	0.0	-0.0	-0.0
Fecal boli incidents, locomotor time 1	0.2	0.2	0.5	-0.3	-0.7	0.4	-0.4	-0.5
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.1
Time >=10cm from walls, locomotor time 1	0.5	0.6	1.4	0.2	-0.0	1.2	-1.1	-0.3
Bouts of movement, locomotor time 1	0.6	0.6	1.1	1.1	1.0	-0.2	0.2	0.9
Total resting periods, locomotor time 1	0.6	0.7	1.3	1.2	0.9	-0.3	0.4	0.9
Rest time, locomotor task time 1	1.4	1.5	1.6	1.2	1.1	-1.3	1.3	1.3
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.1	-0.0	0.2	-0.2	-0.2
Vertical activity count, locomotor time 1	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	0.0
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.5	-0.3	-0.1	0.7	-0.7	0.0
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.1	-0.2	0.0	-0.1	-0.1
Total resting periods, locomotor time 2	0.1	0.1	0.1	0.4	0.2	-0.4	0.4	0.3
Rest time, locomotor task time 2	3.3	3.8	4.3	1.7	1.9	-2.0	2.1	2.0
Distance moved, locomotor task time 2	0.5	0.5	0.8	-0.6	-0.4	0.9	-0.9	-0.6
Vertical activity count, locomotor time 2	2.3	2.6	3.6	-0.9	-1.3	1.9	-1.9	-1.7
Light reinforcement 1	0.1	0.2	0.5	-0.4	-0.5	0.3	-0.3	-0.7
Light reinforcement 2	3.3	4.4	5.3	-1.6	-2.0	2.3	-2.3	-2.2
Bone: marrow area	0.3	0.7	1.2	-1.1	-0.8	0.7	-0.7	-0.7
Bone: maximum diameter	0.2	0.4	0.7	-0.5	-0.8	0.6	-0.6	-0.6
Bone: maximum force	0.2	0.4	0.6	-0.3	-0.7	0.8	-0.8	-0.4
Bone: maximum moment	0.3	0.5	0.7	-0.5	-0.8	0.7	-0.7	-0.5
Mean time between licks in bursts	4.0	5.7	7.1	2.1	2.0	-2.7	2.7	2.4
Mean num. licks in bursts	4.8	5.7	7.1	-2.4	-1.8	2.7	-2.6	-2.3
Cd content in liver	0.0	0.0	0.0	0.0	-0.0	-0.2	0.2	0.0
Co content in liver	0.8	1.0	1.3	-1.2	-1.1	0.8	-0.8	-1.0
Cu content in liver	0.4	0.5	0.8	0.9	0.2	-0.9	0.8	0.3
Fe content in liver	0.3	0.3	0.5	0.5	0.7	-0.6	0.6	0.4
K content in liver	2.8	2.8	3.3	-1.3	-1.8	1.7	-1.8	-1.7
Mg content in liver	4.6	4.7	5.8	-1.5	-2.4	2.2	-2.2	-2.4
Mn content in liver	1.0	1.1	1.9	-0.0	-0.8	1.2	-1.3	-1.4
Na content in liver	0.9	1.0	1.4	-0.6	-1.2	1.1	-1.1	-0.8
Rb content in liver	0.1	0.1	0.2	0.5	0.0	-0.2	0.1	0.2
Se content in liver	0.1	0.1	0.5	0.7	-0.1	0.2	-0.2	-0.4
Sr content in liver	0.3	0.2	0.4	-0.5	-0.1	0.7	-0.6	-0.3
Zn content in liver	1.6	1.8	2.6	-1.0	-1.5	1.2	-1.2	-1.6
Bone: minimum diameter	0.7	1.2	2.7	-1.5	-1.6	0.6	-0.6	-0.8
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.5	-0.3	-0.1	0.1	0.1
Time in novel zone, hab. session 1	0.1	0.1	0.4	0.1	0.6	-0.2	0.2	0.1
Total zone transitions, hab. session 1	0.4	0.6	1.0	0.8	1.0	-0.6	0.6	0.9
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.4	0.1	-0.5	0.5	0.4
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.0	-0.2	-0.0	0.0	0.2
Time in familiar zone, hab. session 2	0.1	0.2	0.3	0.3	0.3	-0.4	0.4	0.5
Time in novel zone, hab. session 2	0.2	0.2	0.3	-0.1	-0.0	0.5	-0.5	-0.5
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.5	-0.1	0.4	-0.4	0.0
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.6	-0.4	0.3	-0.3	-0.0
Locomotion velocity, hab. session 2	0.2	0.3	0.6	-0.8	-0.6	0.5	-0.5	-0.2
Novel to familiar place preference ratio	0.0	0.0	0.1	0.4	0.2	-0.1	0.1	0.1
Novelty place preference	0.0	0.0	0.2	0.4	0.1	-0.1	0.1	0.0
Time in novel zone, NPP test	0.1	0.1	0.3	0.6	0.2	-0.2	0.1	0.0
Total zone transitions, NPP test	0.5	0.8	1.7	-1.3	-0.5	0.9	-0.9	-0.6
Total locomotion distance, NPP test	0.3	0.4	0.9	-1.0	-0.5	0.5	-0.5	-0.4
Locomotion velocity, NPP test	0.3	0.4	1.3	-1.2	-0.6	0.3	-0.3	-0.2
Intraocular pressure	0.4	0.6	1.4	-0.6	-0.8	0.6	-0.6	-1.2
Delta distance traveled before/after self-admin	1.7	1.8	2.7	-1.6	-1.7	1.0	-1.0	-1.3
Delta ambulatory time before/after self-admin	5.6	6.1	7.2	-2.6	-2.7	2.2	-2.3	-2.5
Parametrial fat weight	0.1	0.2	0.4	0.0	-0.6	-0.4	0.4	-0.4
Pavlov. Cond. lever latency	2.5	3.2	5.2	2.3	1.8	-1.7	1.7	1.4
Pavlov. Cond. magazine entry latency	0.7	0.9	1.3	-0.6	-0.7	1.1	-1.1	-1.0
Pavlov. Cond. change in total contacts	0.6	0.7	0.8	-0.7	-0.9	0.9	-0.9	-0.8
Pavlov. Cond. index score	2.0	2.5	2.7	-1.6	-1.6	1.7	-1.6	-1.5
Pavlov. Cond. latency score	2.4	3.1	3.4	-1.8	-1.6	1.9	-1.8	-1.6
Pavlov. Cond. lever contacts	1.9	2.2	3.2	-1.8	-1.5	1.4	-1.4	-1.2
Pavlov. Cond. magazine entry number	1.7	2.2	2.5	1.3	1.4	-1.6	1.6	1.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.2	0.3	-0.6	0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.5	2.9	-1.4	-1.6	1.7	-1.7	-1.5
Pavlov. Cond. response bias	1.6	1.9	2.3	-1.3	-1.3	1.5	-1.5	-1.3
Pavlov. Cond. lever latency	0.9	1.2	3.8	1.9	0.9	-0.8	0.7	0.6
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	-0.7	-0.0	0.3	-0.3	-0.5
Pavlov. Cond. change in total contacts	1.0	1.3	2.7	-1.6	-0.8	1.1	-1.1	-1.1
Pavlov. Cond. index score	0.5	0.6	1.9	-1.4	-0.4	0.6	-0.6	-0.6
Pavlov. Cond. latency score	0.7	0.8	1.9	-1.4	-0.4	0.8	-0.8	-0.8
Pavlov. Cond. lever contacts	1.0	1.4	3.9	-2.0	-0.9	0.9	-0.9	-0.7
Pavlov. Cond. magazine entry number	0.2	0.3	1.1	1.0	0.1	-0.2	0.2	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.1	-0.6	-0.1	0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.2	-1.1	0.0	0.3	-0.3	-0.3
Pavlov. Cond. response bias	0.6	0.9	2.9	-1.7	-0.7	0.5	-0.5	-0.6
Time in closed arm before self-admin	8.0	9.0	10.2	-3.2	-3.1	2.9	-2.9	-3.0
Time in closed arm after self-admin	4.5	4.6	5.4	-1.9	-2.0	2.3	-2.3	-2.2
Time in open arm before self-admin	5.0	5.4	7.6	2.5	2.8	-2.0	2.0	2.3
Time in open arm after self-admin	1.1	1.2	2.0	0.8	1.1	-1.0	1.0	1.4
Bone: periosteal estimation	0.2	0.4	0.6	-0.8	-0.8	0.6	-0.5	-0.5
Bone: periosteal perimeter	0.5	0.9	1.2	-0.8	-1.1	0.9	-0.9	-0.9
Bone: post-yield work	3.1	4.3	5.5	-1.8	-2.0	2.3	-2.3	-1.8
Progressive ratio test 1 active lever presses	1.4	1.4	2.0	1.4	1.2	-0.9	0.9	1.4
Progressive ratio test 1 breakpoint	1.2	1.3	2.0	1.3	1.2	-0.8	0.8	1.4
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.5	0.5	-0.1	0.1	0.5
Progressive ratio test 2 active lever presses	0.5	0.5	1.0	1.0	0.7	-0.6	0.5	0.8
Progressive ratio test 2 breakpoint	0.2	0.2	0.7	0.8	0.4	-0.3	0.3	0.4
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.3	0.0	0.0	-0.1	0.3
Incentive Sensitization - Responses	0.6	0.6	0.8	0.9	0.6	-0.8	0.8	0.7
Incentive Sensitization - Breakpoint	0.6	0.6	0.8	0.9	0.5	-0.9	0.9	0.7
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.6	0.6	0.7	-0.6	0.7	0.7
Progressive ratio	0.2	0.3	0.4	0.5	0.4	-0.7	0.6	0.3
Food seeking constrained by brief footshock	2.3	2.8	3.5	1.9	1.6	-1.8	1.7	1.4
Seeking ratio, punishment vs. effort	0.2	0.2	0.3	0.6	0.5	-0.4	0.4	0.5
Retroperitoneal fat weight	0.1	0.2	0.9	-0.1	-0.6	0.1	-0.1	-0.9
Reaction time number correct	0.4	0.6	1.0	-0.3	0.7	-1.0	1.0	0.7
Reaction time mean minus median	0.8	1.1	2.5	-0.8	-1.6	0.9	-0.9	-0.8
Reaction time mean minus median AUC	0.5	0.7	2.0	-0.7	-1.4	0.6	-0.6	-0.5
Reaction time num false alarms	0.2	0.2	0.9	-0.2	-0.9	-0.4	0.3	-0.1
Reaction time num false alarms AUC	0.2	0.2	0.4	0.1	-0.6	-0.6	0.6	0.1
Reaction time trials correct on left	0.4	0.6	1.0	-0.3	0.7	-1.0	1.0	0.7
Reaction time trials on left	0.5	0.7	1.1	-0.2	0.7	-1.1	1.1	0.8
Reaction time mean	0.3	0.4	0.7	0.8	-0.0	-0.7	0.7	0.6
Reaction time mean AUC	0.2	0.3	0.5	0.7	-0.0	-0.6	0.6	0.5
Median of all reaction times	1.2	1.6	2.2	1.5	0.8	-1.3	1.3	1.3
Reaction time omissions	1.2	1.6	3.2	1.8	1.4	-0.9	0.9	1.1
Reaction time false alarm rate	0.1	0.2	0.8	0.2	-0.9	-0.1	0.1	-0.3
Reaction time premature initiation rate	1.8	2.4	3.7	-1.0	-1.1	1.9	-1.9	-1.6
Reaction time premature initiations	1.0	1.5	2.0	-1.1	-0.8	1.4	-1.4	-1.2
Std. dev. reaction times	0.3	0.5	1.6	-0.2	-1.3	0.4	-0.4	-0.6
Reaction time trials completed	0.5	0.7	1.1	-0.2	0.7	-1.1	1.1	0.8
Reaction time trials AUC	0.6	0.9	1.4	-0.0	0.9	-1.2	1.2	1.0
Run reversals in cocaine runway, females	0.5	0.5	0.8	0.5	0.5	-0.9	0.9	0.6
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.3	-0.2	0.2	-0.2	-0.4
Latency to leave start box in cocaine runway	0.6	0.7	1.3	0.2	1.0	-0.7	0.7	1.1
Latency to leave start box in cocaine runway, F	0.7	0.8	1.0	0.6	1.0	-0.9	0.9	1.0
Latency to leave start box in cocaine runway, M	1.0	0.9	1.7	0.8	1.2	-0.6	0.7	1.3
Std. dev. time between licks in bursts	0.6	0.8	1.3	1.1	0.8	-0.8	0.8	0.8
Total sessions with >9 infusions	0.7	0.8	1.4	1.2	1.0	-0.7	0.7	0.8
Short access day 1 total inactive lever presses	2.9	3.2	5.7	-1.7	-2.4	1.6	-1.6	-1.5
Short access day 10 total inactive lever presses	5.6	6.2	8.9	-2.6	-3.0	2.2	-2.2	-2.4
Short access day 1 total infusions	0.0	0.1	0.2	-0.2	-0.4	0.2	-0.2	0.1
Short access day 10 total infusions	1.4	1.5	2.5	1.4	1.1	-1.0	1.0	1.6
Short access total infusions	0.8	0.9	1.4	1.0	0.5	-1.0	0.9	1.2
Short access day 1 locomotion	0.2	0.2	0.5	0.2	0.7	-0.2	0.2	0.7
Short access day 10 total locomotion	0.1	0.1	0.1	-0.0	-0.4	0.4	-0.4	-0.0
Short access total locomotion	0.1	0.1	0.2	0.0	0.1	0.4	-0.4	0.1
One hour access (0.3 mA shock)	1.7	2.0	3.5	1.9	1.5	-0.9	0.9	1.6
Compulsive drug intake	1.0	1.0	1.1	0.9	1.0	-1.0	1.0	1.1
One hour access (shock baseline)	0.6	0.7	1.5	1.2	0.9	-0.2	0.2	0.9
Social response proportion	0.5	0.5	1.5	0.8	1.2	0.3	-0.3	0.4
Social responses	0.7	0.8	1.0	-0.9	-0.8	1.0	-1.0	-0.9
Social time	0.2	0.3	0.7	0.0	0.8	-0.2	0.2	0.9
Soleus weight	3.1	9.0	11.8	-2.9	-2.7	3.4	-3.4	-2.5
Bone: stiffness	1.0	1.6	2.2	-0.4	-1.4	1.5	-1.5	-1.2
Tibialis anterior weight	6.6	22.6	28.6	-4.9	-5.3	4.5	-4.5	-4.3
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	-0.2	0.1	-0.2	0.2	0.1
Time to tail flick, vehicle, after self-admin	0.6	0.6	0.8	-0.9	-0.6	0.8	-0.7	-0.8
Time to tail flick, test, before self-admin	0.2	0.2	0.6	-0.0	-0.1	0.8	-0.7	0.2
Time to tail flick, test, after self-admin	0.7	0.7	1.9	-0.1	1.2	-0.4	0.5	1.4
Delta time to tail flick, vehicle, before/after SA	0.6	0.5	0.7	-0.5	-0.6	0.9	-0.8	-0.8
Delta time to tail flick, test, before/after SA	0.8	0.7	1.0	-0.0	0.9	-1.0	1.0	0.9
Tibia length	0.0	0.1	0.2	-0.4	0.2	-0.3	0.3	0.2
Ambulatory time before self-admin	0.2	0.3	0.5	-0.4	0.1	0.7	-0.7	-0.5
Ambulatory time after self-admin	3.7	4.0	5.3	-2.3	-1.5	2.0	-2.0	-2.1
Bone: tissue strength	3.0	2.9	4.2	-1.7	-2.1	1.5	-1.5	-1.6
Total heroin consumption	0.1	0.2	0.3	-0.5	-0.1	0.5	-0.5	-0.4
Bone: trabecular number	2.2	3.4	5.1	-2.3	-1.1	2.0	-2.0	-1.6
Bone: trabecular spacing	2.5	3.2	4.8	1.5	0.9	-2.2	2.2	1.9
Bone: trabecular thickness	3.3	4.0	4.9	-2.0	-1.6	2.2	-2.2	-1.9
Bone: trabecular tissue density	1.0	1.4	2.4	-0.5	-1.6	1.2	-1.2	-1.2
Water consumed over 24 hours	0.1	0.1	0.3	-0.2	0.6	0.1	-0.1	0.4
Number of responses in last shaping day	3.3	3.4	4.7	-1.7	-2.2	1.8	-1.8	-1.7