Hub : Genes

Snrpc

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Snrpc 0.76 0.07 0.0e+00 0.23 0.27 0.3 0.28 3.1e-25 7.1e-30 1.1e-33 7.5e-31
2 Liver intron excision ratio chr20_5897866_5898164 0.39 0.1 0.0e+00 0.19 0.18 0.21 0.2 1.8e-20 2.7e-19 2.5e-23 1.3e-21
3 Liver isoform ratio XM_039098816.2 0.37 0.1 0.0e+00 0.17 0.18 0.22 0.17 2.3e-18 8.0e-20 9.3e-24 5.4e-19
4 Liver intron excision ratio chr20_5897976_5898164 0.52 0.1 0.0e+00 0.23 0.29 0.36 0.27 1.6e-25 5.0e-32 3.8e-42 3.2e-30
5 Liver alternative TSS XM_039098816.2 0.52 0.12 0.0e+00 0.18 0.28 0.33 0.19 2.0e-19 1.6e-30 3.6e-37 2.4e-20
6 Liver isoform ratio NM_001271040.1 0.28 0.1 5.1e-11 0.1 0.09 0.1 0.11 5.2e-11 2.0e-10 4.6e-11 4.0e-12
7 Adipose gene expression Snrpc 0.19 0.07 6.5e-10 0.07 0.07 0.07 0.08 4.8e-08 1.7e-08 2.5e-08 3.0e-09
8 Liver alternative TSS XM_063279219.1 0.2 0.07 0.0e+00 0.16 0.18 0.19 0.16 3.8e-17 4.2e-19 2.7e-20 9.4e-18
9 Liver intron excision ratio chr20_5890395_5891581 0.21 0.09 3.1e-14 0.09 0.09 0.1 0.09 3.2e-10 4.4e-10 1.2e-10 6.6e-10
10 Liver isoform ratio XM_063279219.1 0.06 0.03 2.1e-09 0.07 0.08 0.07 0.05 5.8e-08 6.9e-09 2.9e-08 1.8e-06
11 Liver alternative TSS XM_039098816.2 0.39 0.11 0.0e+00 0.29 0.31 0.35 0.29 1.9e-32 2.0e-35 5.2e-40 6.9e-33
12 Liver alternative TSS NM_001271040.1 0.4 0.11 0.0e+00 0.26 0.32 0.35 0.31 2.2e-29 7.4e-36 1.4e-40 2.7e-35
13 Liver intron excision ratio chr20_5890395_5897641 0.11 0.06 8.2e-06 0.01 0.02 0.02 0.01 3.9e-02 3.4e-03 5.9e-03 1.6e-02
14 Liver alternative TSS NM_001271040.1 0.1 0.05 5.8e-08 0.03 0.06 0.06 0.06 4.1e-04 1.9e-07 1.8e-07 7.8e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.20.6-0.40.4-0.3-0.7-0.20.3-0.30.00.7-0.0-0.20.1-0.60.3
Area under the delay curve0.10.10.50.1-0.30.30.30.3-0.7-0.2-0.10.70.0-0.20.2-0.3-0.0
BMI with tail2.89.613.0-3.23.2-3.3-3.4-3.61.7-3.23.63.23.13.0-3.0-3.0-2.2
BMI without tail1.23.86.6-2.01.8-1.9-1.7-2.30.8-1.82.60.92.22.5-2.4-1.4-1.9
Body weight1.15.016.00.8-1.51.11.2-0.0-3.2-0.31.50.72.73.5-3.3-2.4-4.0
Weight adjusted by age0.71.13.60.8-1.41.21.60.9-1.90.5-0.3-0.50.11.0-0.9-0.2-1.1
Bone surface0.61.02.11.2-1.41.41.21.3-1.31.1-1.0-0.9-0.5-0.40.40.2-0.1
Bone volume0.10.10.50.4-0.50.60.30.5-0.70.2-0.3-0.0-0.0-0.00.0-0.3-0.1
Breakpoint value in progressive ratio session0.40.51.0-0.50.6-0.5-1.0-0.80.2-0.50.60.61.00.6-0.7-0.7-0.6
Number of licking bursts0.81.42.41.5-0.91.01.01.1-0.31.6-1.2-1.4-1.0-1.31.41.11.0
Context. condit. distance diff. score3.23.96.22.4-2.02.01.72.4-1.32.0-2.5-1.3-2.0-2.32.31.31.6
Locomotion velocity, session 12.22.33.91.2-1.31.51.61.7-0.41.6-1.6-1.7-2.0-1.51.51.71.5
Locomotion distance, session 11.11.44.2-0.30.5-0.20.00.31.60.4-0.8-0.9-1.7-1.71.61.52.0
Locomotion velocity, session 21.21.41.91.3-1.11.21.21.3-0.51.3-1.4-1.3-1.1-1.31.31.21.0
Locomotion distance, session 20.40.51.50.1-0.20.30.40.60.40.3-0.8-0.1-1.2-1.11.00.71.2
Locomotion velocity, session 30.50.51.4-0.20.4-0.3-0.1-0.01.00.3-0.5-0.9-0.8-1.01.01.21.2
Locomotion distance, session 31.21.34.2-0.30.8-0.6-0.4-0.11.70.3-0.7-0.5-1.4-1.71.61.42.0
Stereotopy head waving bouts, day 31.51.83.71.8-1.91.81.91.5-1.91.5-1.0-1.2-0.1-0.10.20.4-0.5
Stereotopy head waving duration, day 31.11.32.81.3-1.51.51.71.3-1.41.3-0.9-1.2-0.5-0.30.30.7-0.1
Locomotion velocity, session 70.40.51.7-0.20.1-0.1-0.10.50.30.1-0.90.4-1.1-1.21.0-0.01.3
Locomotion distance, session 70.70.93.0-0.1-0.10.20.10.90.30.1-1.2-0.1-1.7-1.41.20.71.6
Stereotopy head waving bouts, day 70.20.21.1-0.00.1-0.00.2-0.10.50.40.1-0.9-0.3-0.30.31.10.4
Stereotopy head waving duration, day 70.10.10.3-0.10.3-0.2-0.0-0.40.50.30.3-0.60.20.00.00.60.1
Locomotion velocity, session 85.36.410.23.1-3.13.23.03.1-2.52.7-2.9-2.3-1.9-1.81.91.71.0
Locomotion distance, session 82.63.77.01.9-1.61.61.52.2-0.61.6-2.6-1.1-2.3-2.62.61.52.1
Degree of sensitization distance1.21.25.41.0-1.61.41.01.3-2.30.2-0.5-0.10.30.7-0.8-0.8-1.2
Degree of sensitization stereotypy0.60.62.3-0.60.9-0.8-0.6-0.61.50.10.2-0.6-0.5-0.60.71.21.1
Conditioned locomotion0.91.13.10.7-0.90.60.40.1-1.7-0.50.40.91.41.1-1.0-1.4-1.7
Cocaine response after cond. corrected0.30.41.5-0.30.5-0.5-0.7-0.60.1-0.60.60.90.90.4-0.4-1.2-0.5
Cocaine response after cond. not corrected0.10.10.50.7-0.50.40.40.2-0.60.5-0.1-0.40.30.1-0.0-0.3-0.4
Cocaine response before conditioning2.12.56.01.7-1.81.72.11.7-1.42.0-1.4-2.4-1.0-0.40.61.70.1
Saline control response3.24.27.2-2.01.6-1.7-1.5-2.30.6-2.12.71.42.52.7-2.7-1.7-2.3
Bone: connectivity density0.10.10.60.1-0.20.3-0.10.3-0.50.2-0.30.5-0.1-0.00.0-0.7-0.1
Bone: cortical apparent density1.52.03.3-1.61.7-1.8-1.6-1.81.5-1.61.61.21.20.9-0.9-1.0-0.6
Bone: cortical area0.00.00.4-0.1-0.00.00.10.10.10.3-0.0-0.6-0.20.2-0.10.20.0
Bone: cortical porosity0.60.62.40.0-0.30.40.70.60.20.4-0.6-1.1-1.2-0.70.71.61.0
Bone: cortical porosity0.91.01.90.5-1.01.01.31.2-0.60.9-0.9-1.3-1.3-0.70.71.40.9
Bone: cortical thickness2.33.89.3-2.82.9-2.8-2.6-2.33.0-1.71.70.90.40.6-0.7-0.30.5
Bone: cortical thickness4.24.97.7-2.82.6-2.7-2.7-2.62.0-2.52.42.01.81.7-1.8-1.7-1.1
Bone: cortical tissue density1.11.52.5-1.41.5-1.5-1.3-1.61.2-1.41.41.11.10.8-0.8-0.9-0.6
Condit. Reinf. active minus inactive responses0.10.10.3-0.1-0.40.50.50.5-0.5-0.0-0.3-0.3-0.50.1-0.10.30.1
Condit. Reinf. active-inactive response ratio0.60.61.3-0.70.4-0.5-0.4-0.7-0.0-0.91.00.50.91.1-1.1-0.6-1.0
Condit. Reinf. active responses0.10.10.3-0.5-0.0-0.1-0.1-0.0-0.3-0.50.30.40.10.6-0.6-0.4-0.5
Condit. Reinf. inactive responses0.40.51.0-0.90.8-0.9-1.0-0.50.5-1.00.51.00.10.3-0.3-0.7-0.0
Incentive salience index mean0.60.71.40.8-1.01.11.01.2-0.90.8-1.1-0.6-1.0-0.60.60.50.5
Condit. Reinf. lever presses1.01.52.71.4-1.41.41.11.6-1.11.5-1.6-0.6-1.2-1.01.00.40.7
Condit. Reinf. active minus inactive responses0.70.91.80.8-1.21.11.31.2-0.80.7-1.0-1.3-0.9-0.40.41.20.2
Condit. Reinf. active-inactive response ratio0.70.81.60.9-1.11.01.31.0-0.90.8-0.9-1.2-0.6-0.30.30.90.1
Condit. Reinf. active responses0.50.71.30.7-1.00.91.11.2-0.70.5-1.0-1.0-0.9-0.40.41.00.3
Condit. Reinf. inactive responses0.00.00.1-0.2-0.10.00.00.1-0.1-0.40.00.20.10.3-0.3-0.1-0.3
Condit. Reinf. lever presses0.50.72.30.2-0.40.40.70.70.30.4-0.7-1.1-1.4-0.70.71.50.9
Condit. Reinf. lever reinforcers received0.70.91.70.7-1.00.91.11.2-0.40.7-1.1-1.3-1.2-0.60.61.30.6
Conditioned reinforcement - actives0.10.11.0-0.1-0.10.0-0.00.1-0.50.1-0.01.0-0.2-0.10.1-0.60.1
Conditioned reinforcement - inactives0.10.10.4-0.30.1-0.10.10.10.20.0-0.1-0.2-0.6-0.30.40.60.6
Conditioned locomotion0.40.52.60.4-0.90.80.80.6-1.6-0.1-0.30.9-0.00.1-0.1-0.8-0.3
Patch foraging indifference point 0 sec1.52.84.8-1.71.6-1.9-1.5-1.91.0-1.52.21.31.62.0-1.9-1.3-1.5
Patch foraging indifference point AUC1.52.26.11.7-1.51.51.71.5-0.81.8-1.4-2.5-1.2-1.01.11.60.6
Delay disc. indifference point, 0s delay0.10.10.20.4-0.40.40.40.4-0.40.2-0.50.3-0.3-0.40.4-0.10.3
Delay disc. indifference point, 16s delay0.10.10.4-0.60.3-0.3-0.2-0.00.0-0.60.30.6-0.2-0.20.20.10.2
Delay disc. indifference point, 2s delay0.50.50.90.8-0.90.81.00.8-0.90.8-0.9-0.4-0.6-0.60.70.20.4
Delay disc. indifference point, 24s delay0.30.31.3-0.90.2-0.3-0.1-0.1-0.6-1.10.71.00.20.5-0.5-0.3-0.4
Delay disc. indifference point, 4s delay0.20.20.60.5-0.60.50.60.3-0.80.1-0.10.20.30.1-0.1-0.3-0.4
Delay disc. indifference point, 8s delay0.20.21.20.1-0.50.40.30.4-1.1-0.30.10.70.20.2-0.3-0.4-0.4
Indifference point function ln k0.20.30.70.3-0.10.10.10.50.20.5-0.6-0.3-0.8-0.80.80.70.9
Indifference point function log k0.20.30.70.3-0.10.10.10.50.20.5-0.6-0.3-0.8-0.80.80.70.9
Patch foraging total patch changes 0 sec1.73.15.3-2.01.8-2.1-1.7-2.11.3-1.62.31.31.62.0-1.9-1.2-1.4
Patch foraging total patch changes 12 sec0.30.41.2-0.70.9-0.9-0.6-0.91.1-0.20.8-0.30.40.5-0.40.2-0.2
Patch foraging total patch changes 18 sec2.13.24.8-1.92.0-2.1-1.9-2.21.5-1.82.21.41.71.7-1.6-1.5-1.3
Patch foraging total patch changes 24 sec1.52.64.6-2.12.1-2.1-1.8-2.01.9-1.91.81.30.91.0-1.0-0.8-0.4
Patch foraging total patch changes 6 sec1.62.44.0-1.91.9-2.0-1.6-2.01.6-1.82.01.11.21.1-1.0-0.7-0.6
Patch foraging time to switch 0 sec2.55.09.5-2.12.0-2.0-2.4-2.20.8-2.62.33.12.52.0-2.1-2.6-1.8
Patch foraging water rate 0 sec0.10.20.50.4-0.20.10.50.2-0.00.7-0.2-0.6-0.6-0.30.40.50.4
Patch foraging water rate 12 sec0.30.72.8-0.81.1-1.1-0.8-0.71.7-0.50.20.1-0.5-0.80.80.51.1
Patch foraging water rate 18 sec0.20.30.5-0.40.4-0.6-0.4-0.6-0.0-0.30.70.40.50.7-0.6-0.7-0.5
Patch foraging water rate 24 sec0.40.52.0-0.30.9-0.9-0.6-0.61.40.00.0-0.0-0.4-0.90.90.51.0
Patch foraging water rate 6 sec0.20.20.8-0.10.3-0.3-0.1-0.10.90.0-0.1-0.4-0.5-0.60.60.60.8
Seeking ratio, delayed vs. immediate footshock0.10.10.80.5-0.20.20.2-0.10.20.4-0.0-0.90.50.1-0.10.3-0.3
Distance traveled before self-admin0.10.10.60.8-0.40.40.30.1-0.20.7-0.3-0.50.40.0-0.0-0.2-0.2
Distance traveled after self-admin0.50.61.41.2-0.90.80.80.3-0.91.0-0.1-0.80.90.7-0.6-0.3-1.0
Extensor digitorum longus weight1.14.27.62.8-2.62.72.72.5-2.02.4-2.1-1.5-1.4-1.41.51.20.7
Bone: elastic displacement0.30.30.9-0.90.6-0.5-0.2-0.30.9-0.30.2-0.1-0.7-0.40.40.70.9
Bone: elastic work0.20.20.9-0.90.6-0.5-0.4-0.50.4-0.70.60.40.10.3-0.3-0.20.1
Bone: endosteal estimation3.06.520.93.3-3.73.43.32.4-4.62.1-1.2-1.50.81.2-1.0-0.6-2.5
Bone: endosteal perimeter1.73.610.22.8-2.82.62.42.0-3.21.8-1.3-1.20.30.2-0.1-0.2-1.4
Epididymis fat weight12.843.770.2-8.28.3-8.4-8.1-8.06.5-7.57.26.44.94.1-4.2-4.6-2.1
Delta time in closed arm before/after self-admin1.00.91.8-1.30.9-0.9-0.9-1.00.3-1.41.01.30.80.6-0.6-1.0-0.4
Delta time in open arm before/after self-admin0.30.31.10.9-0.50.50.50.3-0.31.0-0.5-0.6-0.2-0.20.20.10.2
Diff in mean of infusions in LGA sessions0.30.30.9-0.50.7-0.6-1.0-0.50.5-0.70.20.90.3-0.30.2-0.50.2
Delay discount exponential model param0.10.10.5-0.10.4-0.3-0.4-0.40.70.10.2-0.60.10.3-0.20.2-0.1
Extinction: sum of active levers before priming0.10.10.4-0.40.5-0.4-0.5-0.30.6-0.20.00.1-0.2-0.20.10.10.2
Active lever presses in extinction session 61.01.02.0-1.40.8-0.8-0.9-0.8-0.2-1.31.21.40.71.0-1.1-0.9-0.7
Bone: final force2.74.36.8-1.71.3-1.6-1.6-2.00.1-2.22.52.12.62.6-2.6-2.4-2.4
Bone: final moment1.83.04.8-1.41.1-1.3-1.3-1.60.0-1.82.11.72.22.2-2.2-2.0-2.0
Food consumed during 24 hour testing period1.11.54.80.3-0.50.40.1-0.3-1.5-0.60.91.01.81.6-1.6-1.7-2.2
Glucose4.26.610.33.1-3.23.23.23.2-2.52.9-2.7-2.3-2.2-1.61.71.81.0
Heart weight0.50.82.00.3-0.70.71.31.0-0.30.9-0.6-1.3-1.4-0.30.31.40.6
Delay discount hyperbolic model param0.10.20.4-0.30.5-0.5-0.5-0.50.7-0.10.4-0.20.30.5-0.5-0.1-0.3
Intermittent access intake day 1-15 change0.20.41.2-0.30.5-0.5-0.8-0.70.2-0.40.60.21.10.8-0.8-0.7-0.7
Intermittent access intake escalation0.40.91.9-0.80.8-0.9-1.1-1.10.3-0.91.00.61.41.1-1.1-0.9-0.9
Intermittent access intake escalation 20.30.41.01.0-0.90.80.60.6-1.00.8-0.6-0.50.10.1-0.1-0.1-0.2
Intermitt. access day 1 inactive lever presses0.31.22.91.2-0.40.50.50.70.91.5-1.1-1.7-0.9-1.21.21.41.3
Intermitt. access day 15 inactive lever presses0.20.41.11.0-1.00.80.80.6-0.70.7-0.2-0.70.30.5-0.50.0-0.7
Intermitt. access escalation Index0.40.52.20.20.6-0.4-0.6-0.21.50.6-0.5-0.4-0.5-1.01.00.51.1
Intermittent access day 1 total infusions0.30.52.1-0.1-0.30.40.40.7-0.40.5-0.60.5-1.5-0.80.90.51.1
Intermittent access day 15 total infusions0.10.10.4-0.60.5-0.5-0.5-0.40.1-0.20.30.4-0.10.1-0.1-0.20.2
Intermittent access terminal intake (last 3 days)0.10.10.4-0.60.4-0.4-0.3-0.20.1-0.20.20.3-0.30.00.00.10.3
Intermittent access total infusions0.10.10.5-0.2-0.10.00.20.2-0.30.3-0.10.2-0.7-0.20.20.20.5
Intermittent access day 1 locomotion0.10.10.20.3-0.40.40.40.4-0.50.3-0.30.4-0.4-0.10.1-0.20.1
Intermittent access day 15 total locomotion0.51.02.80.3-0.80.60.50.1-1.7-0.50.50.91.21.2-1.2-1.3-1.6
Intermittent access total locomotion0.40.52.10.6-1.00.80.90.5-1.50.2-0.10.40.30.6-0.5-0.7-0.8
Intermittent access standard deviation0.81.73.6-0.90.8-1.1-1.0-1.30.1-1.01.60.81.81.9-1.8-1.1-1.6
Left kidney weight0.62.79.10.3-0.80.40.5-0.3-1.9-0.41.40.72.12.7-2.6-1.7-3.0
Right kidney weight0.94.013.00.8-1.41.00.90.0-2.8-0.31.30.82.52.9-2.8-2.3-3.6
Cocaine induced anxiety0.81.13.41.8-1.31.21.21.1-0.51.4-1.1-1.2-0.3-0.60.60.40.2
Post-drug Anxiety0.20.20.90.9-0.60.40.50.4-0.30.4-0.3-0.60.30.2-0.1-0.0-0.5
Baseline Anxiety2.42.85.0-2.22.0-2.0-2.1-1.81.0-2.21.71.91.21.1-1.1-1.2-0.7
Tail length2.710.421.14.1-4.54.34.63.5-4.23.5-2.3-3.9-0.90.00.21.7-1.1
Length with tail3.515.137.35.0-5.85.35.64.3-6.13.8-2.4-3.1-0.31.0-0.80.6-2.4
Length without tail1.54.816.72.3-3.02.52.61.7-4.11.0-0.40.21.21.9-1.7-1.7-2.9
Times rat made contact with spout0.91.02.9-1.41.5-1.3-1.2-1.21.7-1.10.90.50.1-0.0-0.00.10.6
Lifetime Intake0.00.10.2-0.3-0.10.10.20.2-0.40.00.00.4-0.40.00.00.00.2
Liver weight, left1.83.07.82.4-2.42.32.21.5-2.81.8-0.8-1.20.60.8-0.6-0.5-1.7
Liver weight, right5.29.118.84.3-4.34.14.23.4-4.13.2-2.6-2.6-0.8-0.70.91.0-0.8
Locomotor activity0.30.42.30.9-0.40.30.60.40.21.1-0.2-1.5-0.0-0.10.30.80.0
Locomotor testing distance0.20.41.2-0.40.9-0.8-0.8-0.81.1-0.10.7-0.10.70.2-0.2-0.3-0.2
Locomotor testing rearing0.20.41.40.10.2-0.4-0.4-0.5-0.1-0.20.60.41.20.7-0.6-1.0-1.0
Locomotion in novel chamber0.10.10.4-0.30.3-0.2-0.3-0.10.40.2-0.10.2-0.4-0.20.20.10.6
Locomotion in novel chamber post-restriction0.91.52.4-1.10.9-0.8-0.9-1.30.1-1.41.31.21.51.4-1.5-1.5-1.4
Fecal boli incidents, locomotor time 10.30.52.0-0.2-0.1-0.1-0.3-0.2-0.8-0.60.41.40.60.6-0.6-1.2-0.7
Change in fecal boli incidents, locomotor task0.10.10.2-0.10.1-0.2-0.0-0.30.1-0.00.2-0.40.40.2-0.2-0.1-0.3
Time >=10cm from walls, locomotor time 11.51.64.80.10.2-0.3-0.6-1.1-0.5-0.51.11.02.21.8-1.7-2.0-2.0
Bouts of movement, locomotor time 10.30.31.01.0-0.60.70.40.4-0.00.8-0.5-1.0-0.1-0.20.20.40.0
Total resting periods, locomotor time 10.60.71.81.4-1.11.10.90.8-0.61.0-0.7-1.1-0.1-0.10.10.3-0.2
Rest time, locomotor task time 11.01.32.11.1-1.11.11.21.3-0.61.1-1.5-1.0-1.3-1.21.20.91.0
Distance moved, locomotor task time 10.71.01.7-0.90.8-0.8-0.8-1.10.3-0.81.30.81.31.3-1.3-0.8-1.3
Vertical activity count, locomotor time 11.33.16.5-0.90.7-0.9-1.0-1.6-0.3-1.32.11.62.52.5-2.4-2.0-2.5
Time >=10cm from walls, locomotor time 21.92.85.4-1.00.5-0.6-0.7-1.2-1.0-1.61.62.22.22.1-2.1-2.3-2.2
Bouts of movement, locomotor time 21.21.94.02.0-1.92.01.91.4-1.21.4-1.3-1.8-0.2-0.50.50.9-0.1
Total resting periods, locomotor time 21.73.05.62.3-2.12.32.21.8-1.11.9-1.8-2.4-0.8-1.01.01.40.5
Rest time, locomotor task time 21.21.63.51.9-1.31.41.21.2-0.51.7-1.6-1.2-0.9-1.21.20.70.8
Distance moved, locomotor task time 23.03.65.3-1.81.0-1.3-1.2-1.5-0.6-2.22.32.32.02.3-2.3-2.2-2.3
Vertical activity count, locomotor time 21.72.44.5-1.10.3-0.6-0.6-0.9-1.2-1.51.72.01.82.0-2.0-2.0-2.1
Light reinforcement 10.82.04.8-0.71.0-0.9-1.3-1.60.3-1.31.61.62.21.2-1.2-2.1-1.6
Light reinforcement 20.61.02.90.2-0.30.2-0.1-0.4-1.1-0.70.61.31.70.9-0.9-1.7-1.6
Bone: marrow area2.96.320.93.2-3.63.33.22.3-4.61.9-1.0-1.40.91.4-1.2-0.7-2.6
Bone: maximum diameter2.44.47.62.7-2.72.72.62.5-2.42.5-2.2-2.1-1.2-1.01.11.00.2
Bone: maximum force0.50.92.1-0.60.3-0.4-0.4-0.6-0.4-0.81.10.91.11.4-1.4-1.2-1.3
Bone: maximum moment0.20.41.2-0.3-0.0-0.1-0.0-0.2-0.5-0.40.70.50.71.1-1.1-0.8-1.0
Mean time between licks in bursts4.110.014.63.8-3.63.63.73.8-2.43.3-3.6-2.8-2.7-2.82.82.71.7
Mean num. licks in bursts1.11.84.0-2.01.6-1.5-1.4-1.51.3-1.81.41.20.70.9-1.0-0.7-0.3
Cd content in liver1.51.65.3-1.10.7-0.7-0.9-0.9-0.3-1.51.12.31.21.2-1.3-2.1-1.1
Co content in liver4.75.47.1-2.21.8-2.0-2.1-2.30.5-2.72.62.62.42.6-2.6-2.7-2.4
Cu content in liver2.22.66.9-2.32.4-2.2-2.2-1.82.6-1.71.30.90.1-0.10.0-0.01.0
Fe content in liver0.30.41.3-0.40.1-0.3-0.2-0.3-0.4-1.00.61.10.80.6-0.7-0.8-0.8
K content in liver1.71.62.51.2-1.21.21.21.5-0.41.0-1.5-1.0-1.6-1.51.51.31.2
Mg content in liver3.53.65.52.3-2.22.12.12.3-1.31.9-2.1-1.9-1.8-1.71.71.51.0
Mn content in liver7.07.814.23.8-3.73.43.53.6-2.92.8-2.9-2.3-1.9-1.91.91.70.7
Na content in liver0.40.41.4-0.40.6-0.5-0.5-0.31.2-0.1-0.1-0.5-0.4-0.70.70.80.8
Rb content in liver0.20.31.10.1-0.30.30.10.0-0.8-0.30.20.90.40.5-0.5-1.0-0.7
Se content in liver7.58.912.43.2-3.23.23.53.5-1.92.9-3.4-3.3-2.9-2.52.63.11.9
Sr content in liver0.20.20.8-0.3-0.0-0.0-0.0-0.1-0.6-0.40.20.90.30.5-0.5-0.8-0.5
Zn content in liver1.71.83.11.5-1.71.71.71.8-1.21.1-1.6-0.9-1.3-1.11.10.90.7
Bone: minimum diameter1.22.16.11.9-2.11.91.81.5-2.51.5-0.8-0.90.20.5-0.4-0.3-1.2
Time in familiar zone, hab. session 10.70.71.5-1.21.2-1.2-1.2-0.81.2-1.00.50.9-0.10.0-0.1-0.10.4
Time in novel zone, hab. session 10.30.30.70.7-0.60.70.80.4-0.50.8-0.5-0.8-0.1-0.40.40.30.1
Total zone transitions, hab. session 11.31.95.6-0.51.1-0.9-0.6-0.22.40.5-0.6-1.0-1.6-1.71.71.62.3
Total locomotion distance, hab. session 11.21.84.70.10.4-0.10.00.41.60.9-1.1-1.3-1.8-1.91.91.72.2
Locomotion velocity, hab. session 11.11.63.90.20.10.10.20.71.30.9-1.1-1.3-1.8-1.71.71.82.0
Time in familiar zone, hab. session 20.10.10.30.20.1-0.1-0.1-0.10.50.1-0.1-0.40.0-0.40.40.50.2
Time in novel zone, hab. session 20.30.30.9-0.4-0.10.10.1-0.2-0.8-0.30.50.60.50.9-0.9-1.0-0.7
Total zone transitions, hab. session 20.60.72.5-0.10.7-0.6-0.4-0.31.60.3-0.3-0.6-0.7-1.21.20.81.3
Total locomotion distance, hab. session 21.21.64.40.20.7-0.4-0.30.11.90.7-0.8-0.8-1.3-2.12.01.32.1
Locomotion velocity, hab. session 21.62.25.90.40.5-0.2-0.10.41.90.9-1.2-1.1-1.7-2.42.41.72.4
Novel to familiar place preference ratio0.30.30.8-0.90.7-0.6-0.6-0.50.5-0.80.50.70.10.1-0.1-0.20.3
Novelty place preference0.10.10.4-0.70.5-0.4-0.4-0.40.4-0.50.30.4-0.0-0.00.0-0.00.4
Time in novel zone, NPP test0.10.10.3-0.60.3-0.3-0.2-0.30.2-0.50.30.3-0.0-0.0-0.0-0.00.3
Total zone transitions, NPP test1.11.64.60.30.00.20.30.71.10.8-1.2-1.0-1.8-2.01.91.52.1
Total locomotion distance, NPP test0.40.62.0-0.40.6-0.5-0.4-0.01.2-0.1-0.50.3-1.0-1.21.10.31.4
Locomotion velocity, NPP test0.70.92.9-0.60.9-0.7-0.7-0.21.7-0.2-0.40.3-1.1-1.41.30.51.7
Intraocular pressure0.20.20.60.2-0.30.20.10.1-0.6-0.30.30.70.40.6-0.6-0.8-0.7
Delta distance traveled before/after self-admin0.30.30.70.2-0.50.40.60.1-0.80.20.4-0.20.40.8-0.8-0.1-0.8
Delta ambulatory time before/after self-admin0.30.30.80.5-0.60.50.60.1-0.90.30.2-0.30.50.8-0.7-0.2-0.9
Parametrial fat weight1.84.29.4-0.81.1-1.3-1.6-2.0-0.1-1.52.32.13.12.4-2.4-2.8-2.8
Pavlov. Cond. lever latency4.45.59.6-1.91.8-1.9-1.9-2.50.6-2.52.82.23.12.6-2.6-2.6-2.7
Pavlov. Cond. magazine entry latency4.65.99.62.4-2.32.42.42.7-1.22.8-2.7-3.1-2.6-2.12.22.61.9
Pavlov. Cond. change in total contacts1.21.32.71.0-1.11.11.21.3-0.61.4-1.1-1.6-1.3-0.70.81.40.7
Pavlov. Cond. index score4.86.19.02.2-2.22.32.32.8-1.02.8-2.9-2.7-3.0-2.42.42.72.3
Pavlov. Cond. latency score4.65.98.42.2-2.22.32.32.8-1.12.7-2.9-2.6-2.9-2.42.42.62.2
Pavlov. Cond. lever contacts3.13.86.41.6-1.51.71.62.2-0.72.1-2.4-1.7-2.5-2.12.11.92.1
Pavlov. Cond. magazine entry number3.44.37.4-1.81.7-1.8-1.9-2.20.6-2.42.32.72.51.9-2.0-2.5-1.9
Pavlov. Cond. intertrial magazine entries2.12.64.9-2.11.5-1.6-1.4-1.50.7-2.21.72.01.31.4-1.5-1.8-1.1
Pavlov. Cond. lever-magazine prob. diff.4.55.59.02.0-1.92.12.12.6-0.82.6-2.8-2.5-3.0-2.42.42.62.4
Pavlov. Cond. response bias5.26.49.12.3-2.22.32.42.8-0.92.9-3.0-2.9-3.0-2.52.62.72.4
Pavlov. Cond. lever latency0.20.31.20.4-0.00.0-0.3-0.3-0.50.10.30.51.00.4-0.3-1.1-0.8
Pavlov. Cond. magazine entry latency0.50.62.70.8-1.21.20.90.9-1.60.4-0.5-0.10.00.4-0.4-0.2-0.7
Pavlov. Cond. change in total contacts0.10.10.5-0.3-0.20.20.30.3-0.0-0.2-0.1-0.5-0.50.2-0.30.70.0
Pavlov. Cond. index score0.30.30.70.3-0.80.80.80.8-0.70.3-0.6-0.5-0.7-0.10.00.70.1
Pavlov. Cond. latency score0.20.30.60.3-0.80.80.80.7-0.70.3-0.5-0.4-0.6-0.10.00.60.0
Pavlov. Cond. lever contacts0.10.20.6-0.60.2-0.20.00.00.6-0.3-0.1-0.3-0.7-0.10.00.80.5
Pavlov. Cond. magazine entry number0.20.20.60.00.3-0.3-0.1-0.00.80.3-0.2-0.5-0.4-0.70.70.60.8
Pavlov. Cond. intertrial magazine entries1.62.44.02.0-1.71.61.51.8-1.01.7-1.7-1.9-1.1-1.41.51.50.8
Pavlov. Cond. lever-magazine prob. diff.0.20.20.50.2-0.70.70.70.6-0.70.2-0.4-0.3-0.50.1-0.10.5-0.0
Pavlov. Cond. response bias0.20.30.90.1-0.60.60.70.8-0.30.2-0.7-0.7-1.0-0.20.20.80.4
Time in closed arm before self-admin0.00.00.10.3-0.30.20.20.3-0.30.1-0.20.1-0.1-0.10.1-0.10.1
Time in closed arm after self-admin0.50.51.6-1.31.0-0.9-0.8-0.60.7-1.00.40.9-0.2-0.30.2-0.30.7
Time in open arm before self-admin0.40.41.30.0-0.20.30.40.50.10.5-0.6-1.0-0.8-0.60.61.10.8
Time in open arm after self-admin0.91.02.31.4-1.11.01.01.0-0.71.5-1.0-1.3-0.7-0.70.70.90.4
Bone: periosteal estimation1.22.67.52.0-2.32.12.11.5-2.71.4-0.7-1.30.40.8-0.7-0.2-1.5
Bone: periosteal perimeter0.50.92.11.3-1.31.21.10.8-1.51.0-0.4-1.00.20.4-0.20.1-0.9
Bone: post-yield work1.31.96.11.7-2.01.91.71.7-2.51.4-0.9-0.4-0.10.5-0.5-0.5-1.0
Progressive ratio test 1 active lever presses0.10.10.6-0.70.3-0.2-0.2-0.2-0.2-0.40.30.8-0.20.2-0.2-0.30.0
Progressive ratio test 1 breakpoint0.10.10.4-0.60.2-0.2-0.1-0.1-0.2-0.30.20.6-0.30.1-0.1-0.20.1
Progressive ratio test 1 inactive lever presses1.01.42.3-1.51.4-1.5-1.5-1.40.9-1.21.31.40.90.8-0.8-1.1-0.6
Progressive ratio test 2 active lever presses0.10.10.4-0.60.5-0.4-0.5-0.30.3-0.20.00.4-0.3-0.30.30.00.5
Progressive ratio test 2 breakpoint0.10.20.4-0.70.6-0.4-0.5-0.30.4-0.20.10.4-0.3-0.30.30.00.5
Progressive ratio test 2 inactive lever presses0.40.61.00.6-0.80.80.90.9-0.70.7-1.0-0.6-0.9-0.80.80.50.7
Incentive Sensitization - Responses0.30.41.20.20.3-0.1-0.20.10.80.8-0.6-0.6-0.9-0.80.80.81.1
Incentive Sensitization - Breakpoint0.20.30.80.00.4-0.2-0.4-0.00.90.7-0.5-0.4-0.7-0.70.60.60.9
Sum of active levers in priming session hrs 5-60.10.00.20.1-0.10.10.20.2-0.20.3-0.1-0.2-0.4-0.20.20.40.2
Progressive ratio1.52.34.9-1.10.9-1.3-1.1-1.50.2-1.41.80.92.22.0-2.0-1.3-2.0
Food seeking constrained by brief footshock0.60.71.7-1.30.8-0.7-0.8-0.80.1-1.01.00.90.50.9-0.9-0.5-0.6
Seeking ratio, punishment vs. effort0.71.03.00.1-0.20.60.50.80.30.7-1.0-0.6-1.7-1.41.41.21.7
Retroperitoneal fat weight0.10.61.4-0.30.2-0.3-0.4-0.6-0.3-0.80.80.91.10.9-0.9-1.2-1.1
Reaction time number correct1.73.24.8-2.12.1-2.2-2.1-2.11.4-2.22.01.81.71.3-1.3-1.3-0.8
Reaction time mean minus median2.56.312.63.5-3.63.53.23.0-3.22.7-2.5-2.0-1.2-0.81.01.0-0.2
Reaction time mean minus median AUC2.05.111.13.0-3.33.22.92.9-3.32.1-2.3-1.1-1.2-0.70.80.6-0.2
Reaction time num false alarms1.11.62.91.7-1.41.31.31.4-0.71.7-1.2-1.6-0.9-0.80.91.20.5
Reaction time num false alarms AUC1.42.24.91.8-1.41.41.51.5-0.52.0-1.4-2.2-1.3-1.11.21.70.8
Reaction time trials correct on left1.73.24.8-2.12.1-2.2-2.1-2.11.4-2.22.01.81.71.3-1.3-1.3-0.8
Reaction time trials on left1.63.04.4-2.02.0-2.1-2.1-2.01.3-2.11.91.71.71.3-1.3-1.3-0.9
Reaction time mean2.03.18.72.4-2.72.52.22.1-3.01.7-1.5-0.6-0.40.00.1-0.2-0.8
Reaction time mean AUC1.82.99.12.2-2.62.42.02.0-3.01.5-1.3-0.4-0.20.2-0.2-0.4-1.0
Median of all reaction times1.01.45.11.5-1.71.61.31.3-2.30.9-0.80.10.10.4-0.4-0.7-1.0
Reaction time omissions1.42.05.32.3-2.01.91.51.6-1.81.9-1.3-1.1-0.3-0.50.60.3-0.3
Reaction time false alarm rate4.05.59.12.7-2.42.42.52.6-1.13.0-2.5-3.0-2.2-1.81.92.41.4
Reaction time premature initiation rate0.00.10.1-0.20.3-0.1-0.2-0.30.30.10.30.20.20.3-0.3-0.2-0.2
Reaction time premature initiations1.01.72.3-1.41.4-1.4-1.4-1.50.9-1.31.51.41.31.2-1.2-1.2-0.9
Std. dev. reaction times3.97.214.63.6-3.83.73.43.3-3.63.0-2.5-2.2-1.3-0.60.81.1-0.4
Reaction time trials completed1.63.04.4-2.02.0-2.1-2.1-2.01.3-2.11.91.71.71.3-1.3-1.3-0.9
Reaction time trials AUC1.63.14.6-2.02.0-2.1-2.1-2.01.3-2.11.91.81.71.3-1.4-1.4-0.9
Run reversals in cocaine runway, females0.50.41.2-1.00.5-0.5-0.4-0.5-0.1-0.90.81.10.20.7-0.8-0.6-0.4
Run reversals in cocaine runway, males3.53.55.92.4-2.42.42.32.2-1.92.4-1.9-1.7-1.3-1.01.11.00.5
Latency to leave start box in cocaine runway0.20.20.6-0.30.5-0.5-0.4-0.10.8-0.0-0.2-0.3-0.5-0.50.60.50.8
Latency to leave start box in cocaine runway, F0.10.10.4-0.30.4-0.4-0.4-0.10.6-0.3-0.20.1-0.4-0.50.50.20.6
Latency to leave start box in cocaine runway, M0.10.10.3-0.30.4-0.4-0.3-0.20.50.20.1-0.5-0.2-0.10.10.40.3
Std. dev. time between licks in bursts5.87.910.93.3-2.93.03.13.2-1.83.0-3.3-2.5-2.5-2.82.82.51.8
Total sessions with >9 infusions0.00.10.2-0.0-0.30.30.40.3-0.40.2-0.1-0.0-0.4-0.00.10.20.2
Short access day 1 total inactive lever presses1.11.53.11.3-1.61.61.81.4-1.61.3-1.2-1.0-0.8-0.60.60.60.2
Short access day 10 total inactive lever presses0.20.52.30.60.3-0.2-0.4-0.21.40.9-0.3-1.50.1-0.40.40.80.4
Short access day 1 total infusions0.30.40.80.4-0.70.80.90.8-0.70.7-0.5-0.3-0.9-0.40.40.60.4
Short access day 10 total infusions0.00.00.1-0.20.1-0.0-0.0-0.1-0.1-0.10.20.4-0.00.2-0.2-0.1-0.1
Short access total infusions0.00.10.3-0.3-0.10.10.20.1-0.5-0.10.10.5-0.30.1-0.1-0.10.0
Short access day 1 locomotion0.20.30.60.4-0.10.20.20.30.50.7-0.4-0.7-0.6-0.50.50.80.6
Short access day 10 total locomotion0.50.92.21.5-1.11.11.30.7-0.41.4-0.8-1.5-0.2-0.10.20.6-0.1
Short access total locomotion0.20.20.50.7-0.70.70.70.4-0.50.5-0.3-0.4-0.00.0-0.00.0-0.2
One hour access (0.3 mA shock)1.21.43.80.60.00.20.20.60.91.3-1.3-0.9-1.6-1.71.71.31.9
Compulsive drug intake0.81.02.21.4-0.70.90.50.90.21.5-1.2-0.9-0.8-1.21.10.61.0
One hour access (shock baseline)0.10.10.5-0.1-0.20.20.30.3-0.30.2-0.3-0.1-0.7-0.40.40.40.6
Social response proportion0.20.30.60.6-0.80.70.80.6-0.70.5-0.3-0.4-0.10.1-0.00.1-0.2
Social responses0.10.20.50.6-0.50.50.60.3-0.20.5-0.3-0.7-0.0-0.20.20.4-0.0
Social time2.94.09.03.0-2.22.31.92.2-1.32.8-2.1-2.4-1.1-1.61.71.30.8
Soleus weight5.817.030.45.4-5.55.45.54.9-4.64.7-4.2-3.7-2.3-2.22.42.20.7
Bone: stiffness0.71.22.0-0.80.6-0.7-0.8-0.90.0-1.11.21.01.31.4-1.4-1.4-1.4
Tibialis anterior weight0.00.10.4-0.00.2-0.1-0.0-0.10.6-0.00.10.1-0.2-0.50.50.30.5
Time to tail flick, vehicle, before self-admin0.20.21.01.0-0.30.1-0.10.10.00.3-0.3-0.30.6-0.20.3-0.3-0.4
Time to tail flick, vehicle, after self-admin0.10.10.50.5-0.30.40.30.2-0.20.7-0.4-0.5-0.2-0.10.10.10.1
Time to tail flick, test, before self-admin0.40.52.3-0.30.7-0.6-0.6-0.41.50.1-0.1-0.6-0.3-0.60.60.70.9
Time to tail flick, test, after self-admin0.90.91.60.8-0.60.80.70.9-0.11.0-1.1-1.3-1.0-1.11.01.20.9
Delta time to tail flick, vehicle, before/after SA0.40.41.9-1.40.8-0.6-0.6-0.50.4-0.70.60.7-0.40.3-0.3-0.10.4
Delta time to tail flick, test, before/after SA0.10.10.3-0.20.0-0.0-0.2-0.1-0.4-0.30.30.50.30.2-0.2-0.4-0.4
Tibia length1.23.310.22.3-2.62.32.11.7-3.21.5-0.7-1.40.91.2-1.0-0.6-2.1
Ambulatory time before self-admin0.00.10.30.4-0.10.10.00.10.10.5-0.3-0.50.1-0.20.20.20.2
Ambulatory time after self-admin0.30.40.90.9-0.70.60.60.2-0.80.8-0.1-0.70.60.5-0.5-0.1-0.7
Bone: tissue strength0.60.61.4-0.70.7-0.7-0.8-0.90.2-0.70.91.20.70.7-0.8-1.0-0.4
Total heroin consumption0.10.10.60.5-0.10.2-0.0-0.00.20.7-0.1-0.80.2-0.0-0.00.4-0.2
Bone: trabecular number0.20.30.7-0.70.7-0.5-0.8-0.30.6-0.40.10.8-0.2-0.30.2-0.50.5
Bone: trabecular spacing0.40.51.80.3-0.50.40.6-0.1-1.0-0.10.5-0.21.01.1-1.0-0.3-1.3
Bone: trabecular thickness0.20.31.3-0.2-0.10.0-0.30.1-0.6-0.40.11.00.40.5-0.5-1.2-0.6
Bone: trabecular tissue density0.60.91.90.8-1.11.01.21.1-0.71.0-0.8-1.4-0.9-0.40.41.30.4
Water consumed over 24 hours0.10.10.40.40.00.10.2-0.00.20.7-0.1-0.4-0.1-0.40.50.20.3
Number of responses in last shaping day2.02.24.20.8-1.11.21.71.5-0.61.3-1.5-1.5-2.1-1.61.62.01.7