Hub : Genes

Snrpc

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver isoform ratio XM_039098816.1 0.31 0.1 6.6e-12 0.12 0.1 0.11 0.12 6.8e-13 8.8e-11 2.4e-12 9.8e-13
2 Liver alternative TSS XM_039098816.1 0.26 0.09 9.2e-10 0.09 0.08 0.09 0.09 2.5e-10 8.3e-09 8.4e-10 2.5e-10
3 Liver gene expression Snrpc 0.83 0.05 0.0e+00 0.26 0.33 0.36 0.34 1.1e-28 1.2e-37 2.0e-42 7.2e-39
4 Liver intron excision ratio chr20_5896094_5896392 0.39 0.1 0.0e+00 0.18 0.18 0.21 0.2 3.9e-20 1.8e-19 2.7e-23 1.5e-21
5 Liver intron excision ratio chr20_5896204_5896392 0.51 0.1 0.0e+00 0.24 0.29 0.37 0.26 8.5e-27 6.0e-32 7.5e-43 4.9e-29
6 Adipose gene expression Snrpc 0.2 0.07 5.2e-10 0.05 0.07 0.06 0.07 2.2e-06 4.1e-08 4.9e-07 2.3e-08
7 Liver isoform ratio XM_006256220.3 0.08 0.05 1.5e-05 0.03 0.03 0.05 0.05 2.1e-04 1.3e-04 6.8e-06 1.9e-06
8 Liver alternative TSS XM_006256220.3 0.09 0.04 2.7e-08 0.06 0.06 0.06 0.03 2.6e-07 3.2e-07 1.2e-07 2.8e-04
9 Liver isoform ratio NM_001271040.1 0.14 0.07 1.1e-06 0.05 0.06 0.07 0.06 3.0e-06 1.8e-07 6.6e-08 3.4e-07
10 Liver intron excision ratio chr20_5888619_5895869 0.11 0.06 1.3e-05 0.02 0.02 0.02 0 1.3e-03 5.8e-03 2.1e-03 1.9e-01
11 Liver alternative TSS NM_001271040.1 0.07 0.04 1.3e-07 0.07 0.06 0.06 0.03 6.5e-08 2.3e-07 1.0e-06 1.5e-04
12 Liver alternative TSS NM_001271040.1 0.07 0.04 1.8e-07 0.06 0.06 0.05 0.04 9.8e-08 2.8e-07 1.3e-06 5.7e-05
13 Liver alternative TSS XM_006256220.3 0.07 0.04 2.5e-07 0.07 0.06 0.05 0.03 4.6e-08 4.5e-07 1.7e-06 2.5e-04
14 Liver mRNA stability Snrpc 0.03 0.02 1.5e-03 0.02 0.02 0.01 0.02 1.1e-03 3.3e-03 2.8e-02 5.6e-03
15 Liver intron excision ratio chr20_5888619_5889805 0.22 0.09 3.4e-14 0.08 0.09 0.11 0.07 2.3e-09 3.3e-10 1.4e-12 4.7e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.21.20.50.50.3-0.50.8-0.50.40.1-0.6-0.1-0.1-0.10.1-0.0-1.1
Area under the delay curve0.20.22.20.20.2-0.00.4-0.4-0.20.10.40.50.1-0.3-0.30.30.2-1.5
BMI with tail1.96.29.02.12.12.8-2.62.6-2.92.5-3.0-0.82.92.72.7-2.72.90.7
BMI without tail0.40.96.10.40.40.6-0.60.3-0.3-0.1-1.3-0.41.11.01.0-1.00.72.5
Body weight0.83.314.5-2.1-2.1-0.41.4-1.3-0.40.2-1.33.81.81.81.8-1.82.51.0
Weight adjusted by age1.11.35.6-1.7-1.7-0.71.4-1.70.7-0.70.42.4-0.1-0.5-0.50.50.4-0.1
Bone surface0.40.71.3-1.2-1.2-1.11.1-1.00.8-0.90.80.8-0.6-0.6-0.60.6-0.70.2
Bone volume0.00.10.1-0.4-0.4-0.30.4-0.10.1-0.10.30.3-0.2-0.2-0.20.2-0.2-0.4
Breakpoint value in progressive ratio session0.70.71.6-0.3-0.30.4-0.71.2-0.40.4-0.9-0.40.91.31.3-1.30.90.8
Number of licking bursts0.70.91.7-0.8-0.8-1.30.8-0.90.9-1.01.0-0.0-1.0-1.0-1.01.0-1.10.8
Context. condit. distance diff. score3.13.76.3-1.8-1.8-2.31.9-1.72.2-2.22.50.8-2.0-1.9-1.91.9-2.0-0.8
Locomotion velocity, session 12.12.34.2-0.5-0.5-1.31.2-1.51.2-1.61.80.3-2.0-2.1-2.12.1-1.9-1.1
Locomotion distance, session 11.01.33.31.31.30.2-0.60.10.1-0.40.9-1.8-1.4-1.5-1.51.5-1.7-0.6
Locomotion velocity, session 21.11.21.8-1.1-1.1-1.31.2-1.21.4-1.21.20.4-1.0-1.1-1.11.1-1.30.5
Locomotion distance, session 20.40.61.20.20.2-0.30.2-0.30.3-0.31.0-0.4-1.0-1.1-1.11.1-1.1-1.1
Locomotion velocity, session 30.30.41.20.70.70.1-0.2-0.10.4-0.40.3-1.1-0.6-0.7-0.70.7-0.90.5
Locomotion distance, session 31.01.13.21.21.20.2-0.70.30.3-0.30.8-1.8-1.2-1.2-1.21.2-1.3-0.8
Stereotopy head waving bouts, day 31.72.14.5-2.1-2.1-1.71.9-1.91.7-1.60.91.8-0.3-0.4-0.40.4-0.51.3
Stereotopy head waving duration, day 31.21.43.2-1.5-1.5-1.31.6-1.81.3-1.30.91.5-0.7-0.8-0.80.8-0.70.5
Locomotion velocity, session 70.70.84.90.60.60.1-0.20.20.0-0.31.1-0.6-1.0-1.0-1.01.0-0.8-2.2
Locomotion distance, session 71.31.66.10.40.4-0.30.3-0.20.5-0.41.6-0.5-1.7-1.7-1.71.7-1.5-2.5
Stereotopy head waving bouts, day 70.10.10.30.50.50.1-0.2-0.10.1-0.20.0-0.6-0.3-0.4-0.40.4-0.40.2
Stereotopy head waving duration, day 70.10.10.50.40.40.3-0.30.0-0.2-0.2-0.4-0.40.30.20.2-0.20.20.7
Locomotion velocity, session 85.36.39.5-3.0-3.0-3.13.0-2.92.9-3.02.72.0-2.0-2.1-2.12.1-2.1-0.1
Locomotion distance, session 82.33.36.4-1.3-1.3-1.91.5-1.52.0-1.82.50.1-2.1-2.1-2.12.1-2.3-1.1
Degree of sensitization distance1.01.03.7-1.8-1.8-1.01.5-1.00.7-0.50.41.90.00.10.1-0.10.10.1
Degree of sensitization stereotypy0.50.52.11.31.30.6-0.90.6-0.40.1-0.2-1.5-0.3-0.4-0.40.4-0.40.0
Conditioned locomotion1.01.23.6-1.7-1.7-0.60.9-0.30.10.3-0.51.91.21.11.1-1.11.20.5
Cocaine response after cond. corrected0.50.61.10.20.20.5-0.70.8-0.70.7-0.7-0.31.11.01.0-1.00.80.6
Cocaine response after cond. not corrected0.20.21.6-0.7-0.7-0.40.4-0.40.3-0.4-0.10.40.40.30.3-0.30.11.3
Cocaine response before conditioning2.22.65.9-1.6-1.6-1.72.0-2.41.8-1.91.31.5-1.4-1.4-1.41.4-1.30.9
Saline control response3.54.68.51.51.52.4-1.91.9-2.42.5-2.9-0.42.42.42.4-2.42.51.0
Bone: connectivity density0.10.10.9-0.1-0.1-0.20.10.20.1-0.20.40.1-0.2-0.2-0.20.2-0.1-0.9
Bone: cortical apparent density1.41.82.81.41.41.6-1.51.3-1.71.5-1.5-0.91.31.31.3-1.31.20.5
Bone: cortical area0.00.00.20.40.40.2-0.2-0.0-0.1-0.2-0.2-0.2-0.0-0.1-0.10.1-0.00.4
Bone: cortical porosity0.90.93.50.30.3-0.10.4-0.70.4-0.10.90.1-1.4-1.4-1.41.4-0.9-1.9
Bone: cortical porosity1.41.53.3-0.5-0.5-0.81.2-1.40.9-0.81.30.9-1.6-1.6-1.61.6-1.0-1.8
Bone: cortical thickness2.74.511.33.43.42.8-2.82.4-2.31.9-1.7-2.80.80.80.8-0.80.8-0.2
Bone: cortical thickness3.94.66.52.42.42.6-2.52.5-2.42.3-2.4-1.91.91.91.9-1.91.60.8
Bone: cortical tissue density1.01.42.11.11.11.4-1.21.0-1.51.3-1.4-0.61.21.21.2-1.21.20.5
Condit. Reinf. active minus inactive responses0.30.31.2-0.1-0.1-0.10.5-0.50.3-0.20.50.6-0.7-0.7-0.70.7-0.4-1.1
Condit. Reinf. active-inactive response ratio0.40.40.90.30.30.7-0.50.4-0.70.8-0.90.20.80.70.7-0.70.90.2
Condit. Reinf. active responses0.10.11.20.20.20.3-0.00.1-0.20.30.00.4-0.2-0.2-0.20.20.2-1.1
Condit. Reinf. inactive responses0.40.51.20.90.90.9-0.91.1-0.80.8-0.3-0.60.30.20.2-0.20.4-1.0
Incentive salience index mean0.91.11.6-0.8-0.8-0.91.0-0.91.1-1.01.30.8-1.2-1.2-1.21.2-0.9-1.1
Condit. Reinf. lever presses1.01.32.3-1.1-1.1-1.31.1-0.91.5-1.41.50.6-1.1-1.1-1.11.1-1.1-0.7
Condit. Reinf. active minus inactive responses1.01.22.4-1.0-1.0-1.01.4-1.61.3-0.91.10.9-1.2-1.2-1.21.2-1.1-0.1
Condit. Reinf. active-inactive response ratio0.91.02.1-1.0-1.0-1.01.2-1.41.3-0.90.91.0-0.9-0.9-0.90.9-0.80.1
Condit. Reinf. active responses0.70.91.6-0.8-0.8-0.81.2-1.21.1-0.61.00.7-1.1-1.0-1.01.0-1.1-0.3
Condit. Reinf. inactive responses0.00.00.2-0.1-0.10.10.10.0-0.10.4-0.10.00.20.10.1-0.1-0.00.1
Condit. Reinf. lever presses0.60.82.10.20.2-0.30.4-0.60.5-0.40.9-0.0-1.5-1.4-1.41.4-1.1-1.1
Condit. Reinf. lever reinforcers received0.81.22.1-0.6-0.6-0.91.2-1.31.2-0.71.20.5-1.4-1.4-1.41.4-1.4-0.4
Conditioned reinforcement - actives0.40.42.60.00.0-0.20.4-0.5-0.00.00.70.6-1.0-0.7-0.70.7-0.0-1.6
Conditioned reinforcement - inactives0.20.20.60.70.70.2-0.1-0.3-0.10.10.1-0.2-0.8-0.6-0.60.6-0.3-0.3
Conditioned locomotion0.91.15.8-0.5-0.5-0.51.0-1.10.1-0.11.11.6-0.9-1.0-1.01.00.2-2.4
Patch foraging indifference point 0 sec1.72.74.81.61.61.9-1.71.5-2.12.2-2.2-0.61.31.61.6-1.61.70.6
Patch foraging indifference point AUC2.12.54.2-1.6-1.6-1.81.7-2.02.0-2.01.31.0-1.1-1.3-1.31.3-1.51.4
Delay disc. indifference point, 0s delay0.20.21.2-0.3-0.3-0.30.3-0.40.3-0.30.60.4-0.2-0.4-0.40.4-0.2-1.1
Delay disc. indifference point, 16s delay0.50.52.01.41.40.4-0.10.1-0.80.70.1-0.5-0.4-0.4-0.40.40.0-1.4
Delay disc. indifference point, 2s delay0.70.81.5-1.0-1.0-0.80.9-1.10.8-0.91.01.2-0.5-0.7-0.70.7-0.4-1.1
Delay disc. indifference point, 24s delay0.70.63.21.11.10.8-0.0-0.1-1.11.1-0.20.30.2-0.1-0.10.10.7-1.8
Delay disc. indifference point, 4s delay0.20.20.8-0.7-0.7-0.30.6-0.50.2-0.30.10.90.50.20.2-0.20.4-0.3
Delay disc. indifference point, 8s delay0.20.21.5-0.0-0.0-0.10.6-0.4-0.30.20.30.80.2-0.1-0.10.10.5-1.2
Indifference point function ln k0.20.21.00.10.1-0.40.2-0.20.2-0.30.6-0.5-1.0-0.6-0.60.6-0.7-0.5
Indifference point function log k0.20.21.00.10.1-0.40.2-0.20.2-0.30.6-0.5-1.0-0.6-0.60.6-0.7-0.5
Patch foraging total patch changes 0 sec1.93.15.21.91.92.1-1.91.6-2.32.3-2.3-0.81.31.61.6-1.61.60.6
Patch foraging total patch changes 12 sec0.60.71.41.21.20.9-1.00.7-0.90.8-1.0-1.00.40.50.5-0.50.31.1
Patch foraging total patch changes 18 sec2.83.65.71.91.92.2-2.22.0-2.12.1-2.4-1.21.71.91.9-1.91.71.1
Patch foraging total patch changes 24 sec2.32.85.32.32.32.2-2.21.9-2.22.2-1.7-1.51.00.90.9-0.90.9-0.2
Patch foraging total patch changes 6 sec2.03.05.22.22.32.1-2.01.6-2.22.3-1.9-1.31.41.21.2-1.21.30.2
Patch foraging time to switch 0 sec3.75.89.01.61.62.4-2.32.8-2.62.8-2.6-1.03.02.82.8-2.82.70.1
Patch foraging water rate 0 sec0.30.51.7-0.0-0.0-0.50.5-1.00.2-0.50.70.4-1.3-1.0-1.01.0-0.6-0.6
Patch foraging water rate 12 sec0.40.62.31.41.40.6-0.90.5-0.50.50.1-1.5-0.6-0.3-0.30.3-0.6-0.4
Patch foraging water rate 18 sec0.10.10.60.50.40.4-0.30.1-0.80.3-0.30.30.00.20.2-0.20.5-0.6
Patch foraging water rate 24 sec0.20.31.60.80.80.2-0.60.2-0.2-0.10.2-1.3-0.5-0.4-0.40.4-0.5-0.1
Patch foraging water rate 6 sec0.20.20.60.50.5-0.1-0.1-0.20.0-0.20.4-0.7-0.7-0.6-0.60.6-0.8-0.0
Seeking ratio, delayed vs. immediate footshock0.40.54.0-0.3-0.3-0.30.10.00.4-0.4-0.6-0.40.70.80.8-0.8-0.12.0
Distance traveled before self-admin0.70.73.2-1.4-1.4-0.80.4-0.20.8-0.8-0.10.20.60.70.7-0.70.01.8
Distance traveled after self-admin1.11.25.9-1.4-1.4-0.70.5-0.30.5-0.6-0.60.41.01.21.2-1.20.42.4
Extensor digitorum longus weight1.03.96.8-2.5-2.5-2.62.5-2.42.1-2.12.01.9-1.5-1.5-1.51.5-1.4-0.1
Bone: elastic displacement0.60.72.51.31.30.7-0.50.2-0.50.30.2-0.7-0.8-0.9-0.90.9-0.5-1.6
Bone: elastic work0.30.41.51.01.00.9-0.60.5-0.90.7-0.3-0.30.0-0.0-0.00.00.3-1.2
Bone: endosteal estimation2.75.917.5-4.1-4.1-2.63.2-2.71.9-1.90.64.20.50.50.5-0.50.62.0
Bone: endosteal perimeter1.73.610.8-3.3-3.3-2.32.4-2.01.8-1.70.82.80.20.20.2-0.20.11.7
Epididymis fat weight9.321.736.15.95.96.0-5.65.1-5.65.3-4.7-3.83.93.53.5-3.53.7-0.6
Delta time in closed arm before/after self-admin0.30.30.70.20.20.7-0.40.4-0.70.7-0.60.00.60.70.7-0.70.8-0.3
Delta time in open arm before/after self-admin0.00.00.0-0.0-0.0-0.1-0.10.10.1-0.10.10.1-0.1-0.1-0.10.1-0.10.0
Diff in mean of infusions in LGA sessions0.20.20.80.50.50.4-0.50.9-0.40.4-0.1-0.70.20.20.2-0.20.2-0.6
Delay discount exponential model param0.20.22.3-0.2-0.20.1-0.40.40.1-0.1-0.5-0.40.00.40.4-0.4-0.01.5
Extinction: sum of active levers before priming0.10.10.30.20.20.2-0.40.4-0.00.0-0.1-0.5-0.40.10.1-0.1-0.10.1
Active lever presses in extinction session 61.31.32.40.90.91.5-1.01.1-1.51.6-1.00.30.70.90.9-0.91.6-1.3
Bone: final force2.94.67.90.80.82.0-1.51.7-2.62.5-2.70.22.72.72.7-2.72.80.8
Bone: final moment2.03.25.90.70.71.7-1.21.4-2.22.1-2.20.42.32.22.2-2.22.40.4
Food consumed during 24 hour testing period1.01.22.4-1.1-1.1-0.10.40.1-0.20.3-1.01.41.51.51.5-1.51.41.1
Glucose6.39.513.6-2.9-2.9-3.63.5-3.73.4-3.43.62.4-2.9-3.0-3.03.0-2.6-1.5
Heart weight1.72.44.90.30.3-1.01.2-1.91.0-1.41.70.1-2.2-2.2-2.22.2-2.0-1.1
Delay discount hyperbolic model param0.20.31.70.10.10.3-0.60.6-0.10.2-0.6-0.60.10.40.4-0.40.11.3
Intermittent access intake day 1-15 change0.60.62.0-0.2-0.20.3-0.50.7-0.00.0-0.8-0.51.31.11.1-1.10.41.4
Intermittent access intake escalation0.70.72.3-1.0-1.0-0.30.10.30.5-0.5-0.40.11.31.11.1-1.10.41.5
Intermittent access intake escalation 23.02.96.9-2.6-2.6-2.42.0-1.62.3-2.31.61.4-0.7-0.6-0.60.6-0.90.7
Intermitt. access day 1 inactive lever presses0.40.43.1-0.0-0.0-0.5-0.20.10.7-0.7-0.1-1.20.10.20.2-0.2-0.91.7
Intermitt. access day 15 inactive lever presses0.50.53.3-0.7-0.7-0.30.4-0.30.2-0.2-0.70.40.70.80.8-0.80.31.8
Intermitt. access escalation Index0.30.31.80.30.30.0-0.70.80.2-0.2-0.1-1.40.40.30.3-0.3-0.50.7
Intermittent access day 1 total infusions0.91.05.30.50.5-0.00.2-0.4-0.10.11.00.3-1.7-1.3-1.31.3-0.3-2.3
Intermittent access day 15 total infusions0.10.10.20.20.20.3-0.40.4-0.20.2-0.0-0.2-0.10.00.0-0.00.2-0.5
Intermittent access terminal intake (last 3 days)0.10.10.60.00.00.00.1-0.20.0-0.00.30.3-0.5-0.4-0.40.40.1-0.8
Intermittent access total infusions0.30.32.00.30.30.00.1-0.3-0.20.20.50.5-1.0-0.7-0.70.70.1-1.4
Intermittent access day 1 locomotion0.20.20.4-0.3-0.3-0.40.5-0.60.2-0.20.50.7-0.5-0.5-0.50.5-0.1-0.6
Intermittent access day 15 total locomotion0.70.83.3-1.3-1.3-0.51.1-0.70.1-0.1-0.11.80.90.70.7-0.71.10.0
Intermittent access total locomotion0.70.84.3-1.3-1.3-0.71.2-1.00.3-0.30.32.10.20.10.1-0.10.8-0.5
Intermittent access standard deviation1.51.63.30.20.20.9-0.80.9-1.01.0-1.8-0.11.41.71.7-1.71.41.8
Left kidney weight0.30.84.3-1.3-1.3-0.51.2-0.90.10.2-0.22.10.50.60.6-0.61.00.3
Right kidney weight0.82.26.6-2.5-2.4-1.41.9-1.60.9-0.80.02.60.90.60.6-0.60.71.6
Cocaine induced anxiety0.70.83.5-1.2-1.2-1.20.4-0.21.1-1.20.3-0.20.40.30.3-0.3-0.61.9
Post-drug Anxiety0.50.63.3-1.0-1.0-0.80.3-0.21.0-1.00.00.00.50.30.3-0.3-0.31.8
Baseline Anxiety0.90.92.41.51.51.5-1.00.8-1.21.2-0.8-0.40.40.30.3-0.30.7-0.7
Tail length4.714.325.9-5.1-5.1-4.75.0-5.04.3-4.52.84.2-2.1-2.1-2.12.1-2.22.2
Length with tail2.810.225.3-4.7-4.7-3.74.5-4.43.0-2.92.25.0-1.5-1.3-1.31.3-0.80.4
Length without tail1.02.211.6-2.3-2.3-1.12.0-1.70.4-0.10.43.4-0.00.20.2-0.20.9-1.2
Times rat made contact with spout0.91.12.81.71.71.3-1.41.2-1.11.0-0.7-1.40.10.10.1-0.10.1-0.8
Lifetime Intake0.30.32.50.30.30.20.1-0.3-0.30.30.40.5-0.8-0.6-0.60.60.2-1.6
Liver weight, left2.43.911.1-3.3-3.3-2.22.6-2.31.7-1.60.63.30.60.30.3-0.30.21.5
Liver weight, right8.514.229.4-5.4-5.4-4.75.0-4.84.4-3.83.04.2-1.8-2.0-2.02.0-2.31.8
Locomotor activity0.40.65.8-0.4-0.4-0.60.4-0.70.3-0.8-0.2-0.3-0.00.30.3-0.3-0.42.4
Locomotor testing distance0.61.04.10.90.90.7-1.00.8-0.80.2-1.1-1.50.80.90.9-0.90.22.0
Locomotor testing rearing0.50.83.3-0.4-0.40.1-0.20.3-0.50.2-1.00.01.21.21.2-1.20.81.8
Locomotion in novel chamber0.20.21.00.20.2-0.0-0.10.0-0.00.00.4-0.2-1.0-0.6-0.60.6-0.2-0.9
Locomotion in novel chamber post-restriction1.01.22.30.50.51.2-0.90.9-1.11.2-1.20.01.41.41.4-1.41.50.1
Fecal boli incidents, locomotor time 10.20.20.9-0.1-0.10.10.20.2-0.50.4-0.10.70.20.40.4-0.40.8-0.9
Change in fecal boli incidents, locomotor task0.10.10.6-0.4-0.4-0.1-0.0-0.30.5-0.5-0.0-0.10.1-0.1-0.10.1-0.40.7
Time >=10cm from walls, locomotor time 12.62.65.8-1.4-1.40.2-0.50.8-0.30.4-1.60.92.42.32.3-2.31.92.1
Bouts of movement, locomotor time 10.50.51.5-1.0-1.0-1.00.6-0.41.0-1.10.50.1-0.1-0.1-0.10.1-0.61.2
Total resting periods, locomotor time 10.80.92.0-1.4-1.4-1.41.1-0.81.2-1.30.70.6-0.2-0.3-0.30.3-0.61.2
Rest time, locomotor task time 11.01.11.8-0.9-0.9-1.11.0-1.01.2-1.31.30.6-1.0-1.2-1.21.2-1.1-0.6
Distance moved, locomotor task time 11.11.22.10.40.41.0-0.90.8-1.11.1-1.4-0.01.31.41.4-1.41.30.8
Vertical activity count, locomotor time 13.23.47.00.00.01.2-0.91.3-1.71.7-2.40.62.42.62.6-2.62.61.4
Time >=10cm from walls, locomotor time 22.22.36.1-0.3-0.31.2-0.70.9-1.41.4-1.61.22.22.12.1-2.12.5-0.2
Bouts of movement, locomotor time 22.12.25.7-2.4-2.4-1.81.8-1.61.8-1.80.71.40.3-0.1-0.10.1-0.61.9
Total resting periods, locomotor time 22.83.06.7-2.6-2.6-2.22.0-1.92.3-2.21.21.3-0.3-0.7-0.70.7-1.21.8
Rest time, locomotor task time 21.51.84.0-2.0-2.0-1.71.1-1.11.9-1.91.30.6-0.6-0.7-0.70.7-1.20.7
Distance moved, locomotor task time 22.12.45.21.21.21.7-0.91.0-2.22.1-1.70.61.51.61.6-1.62.3-0.8
Vertical activity count, locomotor time 21.51.74.80.50.51.1-0.30.6-1.71.6-1.41.11.31.51.5-1.52.2-0.7
Light reinforcement 11.83.36.50.30.31.2-1.31.7-1.41.4-2.2-0.62.42.62.6-2.62.02.3
Light reinforcement 21.01.43.0-1.2-1.20.00.10.4-0.20.6-1.11.01.71.71.7-1.71.51.2
Bone: marrow area2.75.817.4-4.1-4.1-2.63.1-2.61.8-1.80.54.20.60.60.6-0.60.72.1
Bone: maximum diameter2.24.17.0-2.6-2.6-2.62.6-2.52.4-2.41.92.1-1.3-1.3-1.31.3-1.30.6
Bone: maximum force0.50.91.90.30.30.9-0.40.4-1.41.2-1.20.51.21.21.2-1.21.40.2
Bone: maximum moment0.20.41.10.10.10.5-0.10.1-1.00.8-0.70.70.70.70.7-0.71.0-0.2
Mean time between licks in bursts6.28.713.6-3.3-3.3-3.73.5-3.33.5-2.83.31.8-2.8-2.8-2.82.8-2.90.4
Mean num. licks in bursts1.21.43.11.61.61.8-1.51.3-1.31.2-1.1-0.80.70.70.7-0.70.8-1.1
Cd content in liver2.42.64.41.51.51.9-1.61.7-1.81.7-1.5-0.21.61.61.6-1.62.1-1.4
Co content in liver4.55.37.51.91.92.6-2.42.4-2.72.4-2.7-0.92.52.52.5-2.52.60.5
Cu content in liver2.22.77.42.72.71.9-2.11.9-1.81.3-0.5-2.5-0.2-0.1-0.10.1-0.1-1.5
Fe content in liver0.30.31.3-0.2-0.20.20.2-0.1-0.81.1-0.20.80.30.40.4-0.40.6-1.1
K content in liver2.92.94.6-1.3-1.3-1.91.6-1.61.7-1.52.10.6-2.0-2.1-2.12.1-2.0-0.9
Mg content in liver7.67.811.3-2.2-2.2-3.12.7-2.82.8-2.83.41.2-3.2-3.3-3.33.3-3.1-1.2
Mn content in liver7.58.513.5-3.7-3.7-3.73.6-3.53.1-3.12.92.6-2.3-2.3-2.32.3-2.40.3
Na content in liver0.10.10.3-0.1-0.1-0.30.10.00.4-0.50.4-0.4-0.4-0.4-0.40.4-0.50.0
Rb content in liver0.20.31.3-0.5-0.5-0.40.4-0.3-0.0-0.20.41.1-0.0-0.1-0.10.10.3-1.2
Se content in liver11.113.618.7-3.1-3.1-4.03.9-4.24.3-3.74.21.6-4.1-4.0-4.04.0-4.2-0.6
Sr content in liver0.20.20.80.30.30.5-0.20.2-0.40.4-0.10.40.40.40.4-0.40.8-0.9
Zn content in liver1.11.22.9-1.0-1.0-1.01.3-1.30.8-0.71.31.3-1.0-1.0-1.01.0-0.6-1.7
Bone: minimum diameter1.12.05.6-2.3-2.3-1.71.9-1.71.2-1.40.52.4-0.00.00.0-0.00.10.9
Time in familiar zone, hab. session 10.80.72.01.21.21.0-1.01.0-0.71.0-0.3-1.00.0-0.1-0.10.10.1-1.4
Time in novel zone, hab. session 10.30.30.7-0.6-0.6-0.60.6-0.90.5-0.80.30.4-0.2-0.1-0.10.1-0.30.9
Total zone transitions, hab. session 11.01.55.91.71.70.4-1.00.40.0-0.40.6-2.4-1.3-1.2-1.21.2-1.5-0.0
Total locomotion distance, hab. session 11.01.43.60.90.9-0.2-0.3-0.10.6-0.81.1-1.9-1.6-1.6-1.61.6-1.9-0.0
Locomotion velocity, hab. session 10.91.33.50.70.7-0.4-0.1-0.20.7-0.71.1-1.6-1.6-1.6-1.61.6-1.9-0.1
Time in familiar zone, hab. session 20.30.33.1-0.1-0.1-0.1-0.10.30.20.1-0.3-0.80.30.30.3-0.3-0.31.8
Time in novel zone, hab. session 20.30.32.70.20.20.40.0-0.2-0.60.1-0.21.10.10.20.2-0.20.8-1.6
Total zone transitions, hab. session 20.40.63.40.80.80.2-0.80.40.0-0.30.1-1.8-0.3-0.3-0.30.3-0.91.2
Total locomotion distance, hab. session 20.70.95.20.90.9-0.2-0.70.40.3-0.60.6-2.3-0.8-0.9-0.90.9-1.50.9
Locomotion velocity, hab. session 20.91.35.20.70.7-0.4-0.50.20.7-0.81.0-2.3-1.2-1.3-1.31.3-1.90.7
Novel to familiar place preference ratio0.30.31.00.80.80.7-0.60.5-0.60.8-0.3-0.4-0.10.00.0-0.00.3-1.0
Novelty place preference0.20.20.70.60.60.5-0.40.3-0.40.5-0.1-0.2-0.2-0.1-0.10.10.1-0.8
Time in novel zone, NPP test0.10.10.70.40.40.4-0.20.1-0.30.4-0.1-0.0-0.2-0.1-0.10.10.1-0.8
Total zone transitions, NPP test0.91.23.20.60.6-0.4-0.2-0.20.4-0.91.2-1.4-1.5-1.6-1.61.6-1.8-0.5
Total locomotion distance, NPP test0.50.61.71.01.00.3-0.70.5-0.40.10.5-1.2-0.7-0.8-0.80.8-0.8-1.3
Locomotion velocity, NPP test0.70.93.21.31.30.5-1.10.8-0.50.20.4-1.8-0.7-0.8-0.80.8-0.9-1.1
Intraocular pressure0.10.10.4-0.4-0.4-0.20.2-0.0-0.40.20.00.60.10.40.4-0.40.4-0.4
Delta distance traveled before/after self-admin0.10.10.2-0.1-0.10.10.2-0.2-0.20.2-0.40.50.20.30.3-0.30.40.3
Delta ambulatory time before/after self-admin0.10.10.5-0.4-0.4-0.20.3-0.20.1-0.1-0.20.50.20.30.3-0.30.20.7
Parametrial fat weight0.91.84.8-0.0-0.10.7-0.81.0-0.90.6-1.6-0.02.21.81.8-1.81.61.8
Pavlov. Cond. lever latency4.45.59.41.01.02.1-1.82.0-2.42.3-3.0-0.33.03.13.1-3.12.81.9
Pavlov. Cond. magazine entry latency4.76.08.4-1.8-1.8-2.62.5-2.62.9-2.92.81.0-2.8-2.8-2.82.8-2.7-0.2
Pavlov. Cond. change in total contacts1.31.42.1-0.7-0.7-1.11.1-1.41.2-1.41.30.6-1.4-1.5-1.51.5-1.3-0.4
Pavlov. Cond. index score5.16.59.8-1.5-1.5-2.52.3-2.52.8-2.73.10.9-3.1-3.1-3.13.1-2.9-1.3
Pavlov. Cond. latency score4.96.29.3-1.6-1.6-2.52.3-2.52.7-2.63.00.9-3.0-3.0-3.03.0-2.8-1.3
Pavlov. Cond. lever contacts3.74.37.3-0.8-0.8-1.81.6-1.82.1-2.12.70.4-2.6-2.7-2.72.7-2.4-1.9
Pavlov. Cond. magazine entry number3.44.26.51.21.22.0-1.82.1-2.22.4-2.4-0.42.52.52.5-2.52.50.1
Pavlov. Cond. intertrial magazine entries1.92.34.01.71.72.0-1.61.7-2.02.0-1.5-0.61.21.21.2-1.21.5-1.1
Pavlov. Cond. lever-magazine prob. diff.5.06.29.7-1.3-1.3-2.42.2-2.42.7-2.63.10.8-3.1-3.1-3.13.1-2.8-1.5
Pavlov. Cond. response bias5.77.010.5-1.5-1.5-2.62.4-2.72.9-3.03.20.9-3.2-3.2-3.23.2-3.0-1.2
Pavlov. Cond. lever latency0.71.02.5-0.2-0.20.2-0.50.7-0.50.1-1.0-0.11.51.51.5-1.51.11.6
Pavlov. Cond. magazine entry latency0.60.73.0-1.3-1.3-0.81.2-0.90.7-0.50.51.7-0.1-0.2-0.20.20.1-0.7
Pavlov. Cond. change in total contacts0.20.20.60.10.10.10.3-0.30.30.10.40.1-0.7-0.7-0.70.7-0.5-0.8
Pavlov. Cond. index score0.50.61.5-0.5-0.5-0.50.8-0.80.6-0.30.80.8-0.9-0.9-0.90.9-0.6-1.2
Pavlov. Cond. latency score0.40.51.2-0.6-0.6-0.50.8-0.80.6-0.40.70.9-0.7-0.8-0.80.8-0.5-1.1
Pavlov. Cond. lever contacts0.40.51.71.01.00.7-0.40.2-0.40.60.1-0.5-0.7-0.7-0.70.7-0.4-1.3
Pavlov. Cond. magazine entry number0.10.20.90.50.50.0-0.30.1-0.0-0.20.1-0.9-0.3-0.2-0.20.2-0.40.6
Pavlov. Cond. intertrial magazine entries1.92.54.4-1.9-1.9-2.01.7-1.52.1-1.91.40.4-1.0-1.0-1.01.0-1.62.1
Pavlov. Cond. lever-magazine prob. diff.0.30.41.4-0.5-0.5-0.30.7-0.60.5-0.20.60.9-0.7-0.7-0.70.7-0.3-1.2
Pavlov. Cond. response bias0.40.62.20.10.1-0.10.4-0.60.4-0.00.70.4-1.1-1.1-1.11.1-0.7-1.5
Time in closed arm before self-admin0.10.10.60.30.30.10.00.1-0.20.20.10.10.1-0.2-0.20.20.1-0.8
Time in closed arm after self-admin0.40.41.80.90.90.8-0.50.5-0.70.8-0.1-0.30.10.00.0-0.00.4-1.3
Time in open arm before self-admin1.11.21.7-1.0-1.0-1.01.0-1.11.3-1.31.10.5-1.2-1.2-1.21.2-1.10.0
Time in open arm after self-admin1.11.21.7-1.0-1.0-1.21.1-1.21.3-1.31.20.7-1.3-1.2-1.21.2-1.10.0
Bone: periosteal estimation1.02.15.9-2.4-2.4-1.51.9-1.71.1-1.20.12.40.40.40.4-0.40.41.7
Bone: periosteal perimeter0.50.82.2-1.5-1.5-1.01.0-0.90.7-0.70.01.40.30.30.3-0.30.31.2
Bone: post-yield work0.70.93.0-1.5-1.5-1.11.4-1.20.6-0.90.61.7-0.1-0.1-0.10.10.1-0.0
Progressive ratio test 1 active lever presses0.50.53.00.40.40.40.0-0.3-0.30.30.50.4-0.9-0.9-0.90.90.0-1.7
Progressive ratio test 1 breakpoint0.40.42.50.60.60.5-0.2-0.2-0.40.40.30.2-0.8-0.8-0.80.80.0-1.6
Progressive ratio test 1 inactive lever presses1.11.22.11.11.11.5-1.41.3-1.31.3-1.3-0.81.01.01.0-1.01.00.2
Progressive ratio test 2 active lever presses0.10.10.40.40.40.6-0.60.5-0.30.3-0.1-0.30.0-0.0-0.00.00.2-0.6
Progressive ratio test 2 breakpoint0.20.30.70.70.70.8-0.80.8-0.40.4-0.2-0.70.0-0.1-0.10.10.1-0.6
Progressive ratio test 2 inactive lever presses0.91.01.5-0.9-0.9-0.91.1-1.21.1-1.11.11.0-1.0-1.1-1.11.1-0.6-0.7
Incentive Sensitization - Responses0.20.21.00.10.10.1-0.60.70.4-0.4-0.1-1.0-0.10.10.1-0.1-0.40.8
Incentive Sensitization - Breakpoint0.30.31.10.00.00.1-0.70.80.3-0.3-0.3-1.00.10.30.3-0.3-0.30.9
Sum of active levers in priming session hrs 5-60.40.41.30.00.0-0.30.4-0.50.2-0.20.70.3-1.1-0.7-0.70.7-0.3-1.1
Progressive ratio2.63.06.1-0.0-0.01.3-1.01.1-1.31.4-2.30.22.42.52.5-2.51.92.0
Food seeking constrained by brief footshock0.50.61.10.80.81.1-0.80.8-1.11.0-0.7-0.10.30.50.5-0.50.9-0.7
Seeking ratio, punishment vs. effort1.21.43.30.60.6-0.50.3-0.40.5-0.71.4-0.6-1.8-1.8-1.81.8-1.3-1.5
Retroperitoneal fat weight0.20.61.50.30.30.9-0.40.4-1.01.1-0.80.41.20.90.9-0.91.2-0.3
Reaction time number correct2.33.34.31.71.72.1-2.02.1-1.91.9-2.0-1.42.02.02.0-2.01.50.7
Reaction time mean minus median5.26.914.4-3.8-3.8-3.43.3-2.93.1-2.92.33.1-1.5-1.5-1.51.5-1.40.2
Reaction time mean minus median AUC4.76.111.9-3.5-3.5-3.03.1-2.72.7-2.42.43.3-1.5-1.5-1.51.5-1.1-1.1
Reaction time num false alarms0.91.32.3-1.4-1.4-1.51.3-1.21.3-0.90.80.5-1.2-0.8-0.80.8-1.01.2
Reaction time num false alarms AUC1.21.72.8-1.3-1.3-1.71.4-1.51.6-1.31.00.3-1.5-1.1-1.11.1-1.41.5
Reaction time trials correct on left2.33.34.31.71.72.1-2.02.1-1.91.9-2.0-1.42.02.02.0-2.01.50.7
Reaction time trials on left2.23.14.01.61.62.0-1.92.0-1.91.8-2.0-1.31.92.02.0-2.01.50.7
Reaction time mean2.43.48.5-2.9-2.9-2.32.4-2.01.8-1.91.52.9-0.6-0.6-0.60.6-0.3-0.4
Reaction time mean AUC2.33.18.7-2.9-2.9-2.22.3-1.81.6-1.71.33.0-0.4-0.5-0.50.5-0.1-0.4
Median of all reaction times1.01.34.3-2.0-2.0-1.41.5-1.10.9-1.10.72.1-0.0-0.0-0.00.00.2-0.2
Reaction time omissions1.31.84.3-2.1-2.1-1.91.6-1.31.5-1.71.01.4-0.5-0.4-0.40.4-0.60.8
Reaction time false alarm rate3.44.87.0-2.0-2.0-2.62.4-2.52.5-2.22.11.0-2.6-2.3-2.32.3-2.20.7
Reaction time premature initiation rate0.10.10.20.30.30.2-0.40.3-0.30.2-0.4-0.20.10.30.3-0.30.3-0.1
Reaction time premature initiations1.31.82.71.11.11.4-1.41.5-1.41.3-1.6-0.81.41.61.6-1.61.30.3
Std. dev. reaction times5.57.715.9-4.0-4.0-3.53.5-3.23.1-3.12.43.5-1.6-1.6-1.61.6-1.30.1
Reaction time trials completed2.23.14.01.61.62.0-1.92.0-1.91.8-2.0-1.31.92.02.0-2.01.50.7
Reaction time trials AUC2.33.34.21.61.62.0-1.92.0-1.91.9-2.0-1.42.02.02.0-2.01.50.8
Run reversals in cocaine runway, females0.90.82.41.31.31.1-0.60.6-1.21.4-0.5-0.1-0.10.30.3-0.30.9-1.5
Run reversals in cocaine runway, males3.13.05.1-1.9-1.9-2.32.2-2.12.0-2.01.81.5-1.5-1.5-1.51.5-1.40.0
Latency to leave start box in cocaine runway0.10.10.30.40.30.1-0.40.10.0-0.10.1-0.6-0.4-0.4-0.40.4-0.50.0
Latency to leave start box in cocaine runway, F0.10.10.20.20.20.0-0.30.10.1-0.10.2-0.4-0.4-0.3-0.30.3-0.5-0.2
Latency to leave start box in cocaine runway, M0.20.20.90.70.60.5-0.70.4-0.20.2-0.3-0.9-0.1-0.1-0.10.1-0.30.5
Std. dev. time between licks in bursts5.97.110.7-2.7-2.7-3.33.0-3.03.1-2.73.11.3-2.6-2.6-2.62.6-2.70.0
Total sessions with >9 infusions0.40.52.5-0.0-0.0-0.10.4-0.5-0.00.00.70.8-0.9-0.8-0.80.8-0.0-1.6
Short access day 1 total inactive lever presses1.51.72.7-1.2-1.2-1.31.5-1.51.3-1.31.71.2-1.1-1.3-1.31.3-0.7-1.3
Short access day 10 total inactive lever presses1.31.512.4-0.8-0.8-0.6-0.20.41.0-1.0-0.7-1.30.90.90.9-0.9-0.83.5
Short access day 1 total infusions1.61.74.5-0.1-0.1-0.81.0-1.30.6-0.61.50.7-2.1-1.8-1.81.8-0.9-2.1
Short access day 10 total infusions0.00.00.10.10.10.2-0.00.0-0.20.2-0.20.2-0.20.10.1-0.10.3-0.2
Short access total infusions0.40.42.20.20.20.00.3-0.5-0.20.20.50.5-1.0-0.8-0.80.8-0.0-1.5
Short access day 1 locomotion0.20.20.60.10.1-0.2-0.10.00.3-0.30.4-0.7-0.5-0.5-0.50.5-0.80.1
Short access day 10 total locomotion1.61.83.4-1.7-1.7-1.61.3-1.71.8-1.91.00.7-1.0-0.9-0.90.9-1.31.2
Short access total locomotion0.30.30.7-0.8-0.8-0.60.7-0.80.5-0.50.30.6-0.2-0.3-0.30.3-0.20.3
One hour access (0.3 mA shock)0.40.51.1-0.2-0.2-0.60.1-0.10.8-0.80.9-0.6-1.0-0.8-0.80.8-1.0-0.4
Compulsive drug intake0.20.20.6-0.1-0.1-0.50.10.10.5-0.50.5-0.8-0.6-0.3-0.30.3-0.70.0
One hour access (shock baseline)0.70.82.2-1.0-1.0-0.81.1-1.20.8-0.81.01.5-0.7-0.8-0.80.8-0.2-0.9
Social response proportion0.30.30.7-0.8-0.8-0.70.8-0.90.5-0.50.30.8-0.4-0.3-0.30.3-0.20.4
Social responses0.20.31.6-0.8-0.8-0.50.4-0.60.5-0.50.00.1-0.00.00.0-0.0-0.21.3
Social time2.93.97.5-2.7-2.7-2.72.0-1.62.6-2.71.50.7-1.0-0.8-0.80.8-1.62.7
Soleus weight5.716.827.9-5.3-5.3-5.25.3-5.24.7-4.73.94.4-2.8-2.7-2.72.7-2.60.4
Bone: stiffness0.71.22.00.30.30.9-0.60.8-1.41.3-1.30.11.41.41.4-1.41.30.8
Tibialis anterior weight0.00.10.70.50.50.1-0.40.4-0.40.3-0.0-0.8-0.3-0.3-0.30.3-0.40.1
Time to tail flick, vehicle, before self-admin0.80.85.5-0.6-0.6-0.5-0.20.50.3-0.4-0.5-0.71.11.11.1-1.1-0.02.3
Time to tail flick, vehicle, after self-admin0.30.31.1-0.9-0.9-0.3-0.20.20.5-0.5-0.20.20.50.40.4-0.40.11.1
Time to tail flick, test, before self-admin0.40.41.90.60.60.5-0.90.8-0.20.2-0.4-1.40.50.30.3-0.3-0.31.0
Time to tail flick, test, after self-admin0.60.61.4-0.7-0.7-0.80.4-0.31.1-1.21.0-0.4-0.2-0.8-0.80.8-1.20.4
Delta time to tail flick, vehicle, before/after SA0.50.53.40.70.70.9-0.60.5-0.60.60.00.1-0.4-0.5-0.50.50.3-1.9
Delta time to tail flick, test, before/after SA0.20.10.50.30.30.3-0.20.5-0.40.4-0.2-0.00.70.40.4-0.40.5-0.3
Tibia length1.43.89.8-3.1-3.1-1.92.4-2.01.7-1.80.22.80.80.70.7-0.70.42.8
Ambulatory time before self-admin0.30.31.4-0.8-0.8-0.40.10.00.5-0.5-0.1-0.10.30.50.5-0.50.01.2
Ambulatory time after self-admin0.60.73.9-1.2-1.2-0.70.5-0.30.6-0.6-0.30.20.50.80.8-0.80.22.0
Bone: tissue strength0.80.81.51.01.01.0-1.00.9-1.21.0-0.7-0.20.70.70.7-0.71.0-1.0
Total heroin consumption0.10.10.8-0.5-0.5-0.40.20.10.2-0.2-0.10.0-0.00.30.3-0.30.10.9
Bone: trabecular number0.30.41.20.90.90.5-0.71.0-0.50.50.2-1.1-0.2-0.2-0.20.2-0.2-1.1
Bone: trabecular spacing0.50.61.6-0.8-0.8-0.10.5-0.50.00.1-0.81.30.90.90.9-0.91.01.0
Bone: trabecular thickness0.10.10.8-0.2-0.20.00.10.3-0.30.20.10.40.10.10.1-0.10.2-0.9
Bone: trabecular tissue density0.91.32.8-1.0-1.0-1.11.5-1.71.1-1.11.11.1-1.1-1.2-1.21.2-0.9-0.2
Water consumed over 24 hours0.00.10.60.10.1-0.3-0.1-0.20.1-0.80.2-0.0-0.1-0.2-0.20.2-0.2-0.0
Number of responses in last shaping day4.34.59.1-0.7-0.7-1.31.7-2.41.5-1.52.51.0-3.0-3.0-3.03.0-1.8-2.2