Hub : Genes

Smurf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Smurf2 0.5 0.14 5.0e-10 0.32 0.31 0.32 0.31 1.8e-08 3.8e-08 1.5e-08 3.8e-08
2 OFC gene expression Smurf2 0.54 0.15 4.0e-07 0.24 0.2 0.2 0.24 2.2e-06 1.4e-05 1.9e-05 2.0e-06
3 Adipose gene expression Smurf2 0.24 0.08 0.0e+00 0.25 0.23 0.27 0.26 4.1e-27 3.7e-25 1.0e-29 6.0e-29
4 Liver gene expression Smurf2 0.2 0.06 0.0e+00 0.22 0.25 0.26 0.26 1.3e-24 9.7e-28 7.5e-29 2.6e-29
5 PL gene expression Smurf2 0.38 0.08 0.0e+00 0.54 0.56 0.58 0.58 4.0e-70 1.3e-74 5.6e-77 3.6e-77
6 pVTA gene expression Smurf2 0.48 0.12 0.0e+00 0.5 0.5 0.52 0.18 2.1e-45 1.4e-45 3.8e-48 8.0e-15
7 NAcc gene expression Smurf2 0.51 0.12 0.0e+00 0.43 0.42 0.43 0.44 2.7e-72 4.0e-70 1.5e-71 3.6e-73
8 PL mRNA stability Smurf2 0.05 0.03 4.9e-06 0.05 0.06 0.07 0.05 8.8e-06 4.0e-07 5.9e-08 1.8e-06
9 Brain mRNA stability Smurf2 0.11 0.05 1.2e-10 0.12 0.12 0.12 0.11 2.5e-11 4.1e-11 4.1e-11 1.1e-10
10 Brain gene expression Smurf2 0.64 0.09 0.0e+00 0.47 0.51 0.51 0.51 1.9e-49 3.9e-55 7.7e-55 2.9e-55
11 BLA gene expression Smurf2 0.48 0.11 0.0e+00 0.48 0.48 0.48 0.51 9.8e-29 3.3e-28 3.3e-28 8.6e-31
12 IC gene expression Smurf2 0.49 0.11 0.0e+00 0.43 0.41 0.47 0.46 8.3e-20 1.6e-18 3.5e-22 3.2e-21
13 NAcc mRNA stability Smurf2 0.03 0.01 4.4e-05 0.03 0.03 0.03 0.03 3.9e-05 7.6e-06 6.6e-05 1.5e-05
14 Adipose mRNA stability Smurf2 0.04 0.02 1.7e-03 -0 0.02 0.02 0.01 5.6e-01 5.3e-03 1.9e-03 7.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.40.71.7-0.9-1.0-1.0-0.8-0.8-0.8-0.7-0.6-0.6-0.6-0.8-0.9-0.4-1.3
Area under the delay curve0.30.31.90.40.10.70.00.30.20.40.50.40.50.30.20.7-1.4
BMI with tail0.10.42.5-1.6-1.2-0.4-0.7-0.5-0.3-0.30.10.20.1-0.1-0.10.10.3
BMI without tail0.41.26.2-2.5-2.0-0.7-1.4-1.0-1.0-0.8-0.3-0.7-0.4-0.5-0.5-0.1-0.0
Body weight1.25.112.4-3.5-3.2-2.1-2.7-2.3-2.4-2.2-1.7-1.9-1.8-1.9-1.8-1.3-1.7
Weight adjusted by age0.50.81.31.11.01.00.90.80.71.01.00.50.90.90.81.0-0.1
Bone surface4.07.39.8-3.0-3.1-3.1-2.5-2.8-2.7-2.7-2.7-2.4-2.7-2.7-2.7-2.0-2.5
Bone volume2.74.97.1-2.6-2.7-2.5-2.2-2.2-2.2-2.2-2.0-1.9-2.1-2.2-2.2-1.4-2.3
Breakpoint value in progressive ratio session0.50.62.90.51.00.20.90.50.60.70.50.30.60.80.90.31.7
Number of licking bursts0.00.00.10.20.2-0.20.30.10.10.20.2-0.10.20.20.30.2-0.0
Context. condit. distance diff. score0.10.10.9-0.1-0.2-0.30.0-0.00.20.20.20.20.10.10.10.21.0
Locomotion velocity, session 10.20.30.6-0.8-0.7-0.5-0.5-0.6-0.5-0.6-0.5-0.3-0.5-0.5-0.4-0.3-0.3
Locomotion distance, session 10.10.10.3-0.4-0.30.2-0.00.10.20.10.20.60.20.00.20.5-0.2
Locomotion velocity, session 20.40.52.1-0.8-0.5-1.2-0.1-0.6-0.3-0.4-0.6-0.6-0.5-0.4-0.1-0.61.4
Locomotion distance, session 20.30.41.40.10.30.10.70.40.70.60.40.90.50.50.80.71.2
Locomotion velocity, session 32.02.33.51.11.30.71.61.41.61.61.61.51.51.61.71.71.9
Locomotion distance, session 30.10.10.20.0-0.0-0.40.40.20.20.20.20.20.20.30.30.40.5
Stereotopy head waving bouts, day 30.91.01.61.21.21.31.01.00.91.01.10.91.01.00.91.0-0.0
Stereotopy head waving duration, day 31.21.42.01.31.41.41.11.21.11.21.31.01.21.21.21.3-0.0
Locomotion velocity, session 70.10.10.30.20.30.10.40.20.40.30.20.40.30.20.10.10.6
Locomotion distance, session 70.00.00.0-0.10.00.2-0.1-0.00.20.1-0.20.10.1-0.10.0-0.00.2
Stereotopy head waving bouts, day 72.12.33.11.51.61.01.71.41.51.71.51.31.51.61.81.41.6
Stereotopy head waving duration, day 72.93.54.92.12.11.12.21.81.92.11.91.51.92.02.11.61.8
Locomotion velocity, session 81.01.22.2-1.2-1.1-1.5-0.9-1.3-1.1-1.1-1.1-1.0-1.1-1.1-1.1-1.1-0.2
Locomotion distance, session 80.10.21.2-0.5-0.5-0.8-0.1-0.30.10.0-0.00.2-0.0-0.1-0.00.01.1
Degree of sensitization distance0.50.51.4-0.5-0.50.2-0.9-0.6-0.7-0.8-0.9-0.6-0.7-0.8-0.8-0.7-1.2
Degree of sensitization stereotypy2.83.16.31.41.50.71.91.61.91.91.71.61.81.82.01.52.5
Conditioned locomotion0.20.20.5-0.5-0.4-0.1-0.7-0.5-0.5-0.4-0.4-0.4-0.4-0.4-0.3-0.6-0.3
Cocaine response after cond. corrected0.30.31.20.90.80.90.60.50.30.30.20.30.20.30.30.5-1.1
Cocaine response after cond. not corrected0.30.41.11.10.90.40.90.70.60.60.40.30.40.50.60.6-0.2
Cocaine response before conditioning0.40.52.70.20.2-0.80.70.50.70.80.70.30.70.70.70.51.6
Saline control response0.30.42.3-0.9-0.6-0.8-0.7-0.5-0.3-0.2-0.2-0.5-0.2-0.10.1-0.71.5
Bone: connectivity density1.11.72.4-1.4-1.4-1.2-1.2-1.4-1.3-1.3-1.2-1.1-1.2-1.3-1.4-0.9-1.6
Bone: cortical apparent density3.95.37.12.32.22.22.32.42.42.42.62.72.52.32.02.60.8
Bone: cortical area0.30.52.2-1.3-1.5-1.3-0.4-0.30.10.00.30.70.20.0-0.20.7-0.1
Bone: cortical porosity2.12.37.0-1.9-1.9-2.6-1.3-1.6-1.2-1.2-1.4-1.4-1.3-1.1-0.9-1.50.8
Bone: cortical porosity1.11.24.8-1.7-1.6-2.2-1.0-1.1-0.8-0.7-0.7-0.8-0.7-0.7-0.6-0.70.6
Bone: cortical thickness9.215.324.52.92.72.83.84.04.44.24.65.04.44.23.74.62.5
Bone: cortical thickness4.65.49.21.51.31.12.22.32.82.52.63.02.62.42.12.52.6
Bone: cortical tissue density3.75.16.62.32.22.22.32.42.42.32.52.62.42.21.92.50.9
Condit. Reinf. active minus inactive responses0.70.82.0-1.3-1.3-1.4-1.1-1.0-0.6-0.5-0.6-0.6-0.5-0.6-0.4-0.80.9
Condit. Reinf. active-inactive response ratio0.40.40.9-0.6-0.6-1.0-0.7-0.7-0.4-0.3-0.5-0.6-0.4-0.4-0.4-0.60.9
Condit. Reinf. active responses1.21.53.6-1.8-1.9-1.9-1.6-1.4-1.0-0.8-0.8-0.9-0.8-0.9-0.8-1.00.2
Condit. Reinf. inactive responses0.81.02.3-1.4-1.5-1.2-1.2-0.9-0.9-0.8-0.6-0.5-0.7-0.8-0.8-0.6-1.4
Incentive salience index mean0.70.82.8-1.3-1.3-1.7-1.0-1.0-0.6-0.5-0.5-0.7-0.5-0.5-0.4-0.70.9
Condit. Reinf. lever presses0.20.21.7-0.3-0.3-1.0-0.1-0.10.10.30.2-0.10.20.20.3-0.11.3
Condit. Reinf. active minus inactive responses1.62.16.7-2.3-2.3-2.6-1.5-1.5-1.1-1.0-1.0-1.0-1.0-0.9-0.9-0.6-0.1
Condit. Reinf. active-inactive response ratio0.80.92.6-1.2-1.2-1.6-1.0-1.1-0.9-0.7-0.8-1.0-0.7-0.7-0.7-0.7-0.2
Condit. Reinf. active responses3.04.19.6-3.0-3.1-3.1-2.3-2.1-1.7-1.7-1.6-1.6-1.6-1.6-1.5-1.2-0.3
Condit. Reinf. inactive responses1.31.75.2-2.3-2.3-1.9-1.6-1.2-0.9-1.0-0.9-0.6-0.9-1.0-0.9-0.70.3
Condit. Reinf. lever presses0.81.14.5-1.8-1.8-2.1-0.9-0.9-0.5-0.5-0.5-0.5-0.4-0.4-0.3-0.51.2
Condit. Reinf. lever reinforcers received2.63.78.3-2.8-2.9-2.9-2.2-2.0-1.6-1.6-1.5-1.5-1.5-1.5-1.5-1.2-0.3
Conditioned reinforcement - actives0.00.00.1-0.3-0.2-0.1-0.20.10.00.10.3-0.10.20.30.30.20.3
Conditioned reinforcement - inactives0.71.02.3-1.5-1.3-1.0-0.9-1.1-0.8-1.1-1.1-0.6-1.0-1.0-0.9-0.90.2
Conditioned locomotion1.21.63.4-1.8-1.7-1.3-1.6-1.4-1.3-1.1-1.0-1.2-1.0-1.0-1.1-1.1-0.5
Patch foraging indifference point 0 sec1.63.07.3-2.7-2.7-2.0-2.2-1.9-1.4-1.6-1.3-0.8-1.3-1.5-1.4-1.0-0.8
Patch foraging indifference point AUC0.81.22.2-1.5-1.4-1.2-1.0-1.1-1.3-1.1-0.9-1.3-1.1-1.0-1.0-0.6-0.6
Delay disc. indifference point, 0s delay0.50.51.41.01.01.20.60.60.40.60.60.40.60.50.40.6-0.8
Delay disc. indifference point, 16s delay0.30.32.30.30.10.7-0.10.20.20.40.60.30.50.40.30.7-1.5
Delay disc. indifference point, 2s delay0.80.96.2-0.6-1.0-0.4-0.9-0.6-0.8-0.7-0.6-0.5-0.6-0.8-0.9-0.1-2.5
Delay disc. indifference point, 24s delay0.50.52.8-0.9-1.0-0.3-0.9-0.6-0.6-0.5-0.2-0.2-0.3-0.3-0.60.1-1.7
Delay disc. indifference point, 4s delay0.80.81.11.10.80.90.90.90.91.11.00.81.00.90.91.00.0
Delay disc. indifference point, 8s delay0.40.51.40.80.61.20.40.60.50.60.70.70.70.50.40.8-1.0
Indifference point function ln k1.01.83.20.90.70.51.11.31.71.51.51.81.61.41.31.41.1
Indifference point function log k1.01.83.20.90.70.51.11.31.71.51.51.81.61.41.31.41.1
Patch foraging total patch changes 0 sec1.73.27.6-2.8-2.7-2.0-2.3-2.0-1.5-1.7-1.5-0.9-1.4-1.6-1.6-1.1-0.9
Patch foraging total patch changes 12 sec4.86.39.1-3.0-2.8-2.2-2.8-2.7-2.7-2.6-2.5-2.3-2.4-2.5-2.3-2.2-1.5
Patch foraging total patch changes 18 sec1.21.84.4-2.1-1.8-1.4-1.5-1.4-1.4-1.4-1.3-1.1-1.3-1.2-1.0-1.00.3
Patch foraging total patch changes 24 sec1.32.35.9-2.4-2.4-1.7-1.8-1.4-1.5-1.4-1.1-1.0-1.2-1.2-1.3-0.6-1.0
Patch foraging total patch changes 6 sec1.82.86.2-2.5-2.5-2.1-1.8-1.8-1.5-1.7-1.4-1.1-1.4-1.6-1.5-1.1-0.4
Patch foraging time to switch 0 sec0.20.41.81.11.41.10.80.40.30.40.10.10.30.40.5-0.20.4
Patch foraging water rate 0 sec1.12.36.1-2.3-2.5-1.7-1.8-1.4-1.2-1.4-1.1-0.8-1.2-1.4-1.5-0.8-0.9
Patch foraging water rate 12 sec0.81.74.60.90.70.81.21.51.61.21.32.11.31.21.11.70.4
Patch foraging water rate 18 sec0.50.73.10.3-0.1-0.10.50.81.20.80.81.70.90.70.61.20.1
Patch foraging water rate 24 sec0.10.20.80.30.20.40.40.40.60.30.20.90.30.40.30.6-0.4
Patch foraging water rate 6 sec0.30.41.70.20.00.30.40.70.80.50.71.30.70.60.41.0-0.4
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.00.00.30.00.20.20.20.40.30.30.30.20.10.2
Distance traveled before self-admin1.01.31.91.31.40.81.41.21.11.11.00.91.11.21.21.20.4
Distance traveled after self-admin0.20.30.90.30.4-0.40.70.50.50.50.30.00.50.50.60.61.0
Extensor digitorum longus weight0.41.58.01.81.82.80.51.10.60.81.00.80.90.70.50.1-0.7
Bone: elastic displacement2.83.24.61.61.41.21.81.82.02.02.12.11.91.91.81.91.1
Bone: elastic work0.20.20.9-0.3-0.4-0.30.30.30.50.50.71.00.50.40.10.60.4
Bone: endosteal estimation15.333.539.7-6.3-6.1-6.2-5.9-6.1-5.8-6.0-6.2-5.9-6.0-5.9-5.4-5.5-2.8
Bone: endosteal perimeter15.332.539.5-6.3-6.2-6.0-5.9-6.0-5.9-5.8-5.9-5.7-5.8-5.7-5.4-5.1-3.6
Epididymis fat weight0.10.50.8-0.9-0.6-0.1-0.7-0.9-0.9-0.7-0.6-0.8-0.7-0.7-0.6-0.6-0.9
Delta time in closed arm before/after self-admin0.20.10.30.00.10.0-0.2-0.3-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.1
Delta time in open arm before/after self-admin0.30.31.10.60.71.00.20.40.30.50.6-0.10.50.60.40.4-0.2
Diff in mean of infusions in LGA sessions2.02.53.61.61.71.51.71.51.71.51.41.71.51.51.51.11.9
Delay discount exponential model param0.20.22.4-0.10.2-0.40.3-0.00.0-0.2-0.3-0.2-0.3-0.10.0-0.51.5
Extinction: sum of active levers before priming0.10.20.40.30.20.40.00.30.30.60.60.20.60.50.40.40.2
Active lever presses in extinction session 60.50.51.0-1.0-0.9-1.0-0.8-0.7-0.6-0.4-0.4-0.8-0.3-0.4-0.3-0.60.7
Bone: final force0.40.62.1-1.3-1.5-1.4-0.5-0.5-0.3-0.5-0.40.1-0.5-0.6-0.70.3-0.9
Bone: final moment0.40.62.2-1.3-1.5-1.5-0.5-0.5-0.3-0.5-0.40.2-0.4-0.5-0.70.3-0.7
Food consumed during 24 hour testing period0.91.22.3-1.5-1.2-0.7-1.3-1.2-1.3-1.2-1.0-1.1-1.0-1.0-0.8-1.0-0.5
Glucose1.42.33.01.71.71.41.71.61.51.41.41.51.41.61.61.50.9
Heart weight1.21.83.21.11.11.61.11.31.31.51.51.51.51.41.31.8-0.4
Delay discount hyperbolic model param0.20.22.5-0.00.3-0.30.30.10.1-0.0-0.2-0.1-0.10.00.1-0.31.6
Intermittent access intake day 1-15 change0.20.51.1-0.3-0.3-0.4-0.7-0.6-0.8-0.7-0.8-0.9-0.9-0.8-0.9-1.0-0.0
Intermittent access intake escalation0.40.81.3-0.7-0.7-0.7-1.0-0.9-1.0-0.8-0.9-1.0-1.0-0.9-1.0-1.1-0.2
Intermittent access intake escalation 21.71.93.0-1.1-1.0-1.0-1.4-1.3-1.6-1.4-1.5-1.7-1.5-1.5-1.6-1.7-0.5
Intermitt. access day 1 inactive lever presses0.62.23.8-1.9-1.9-1.9-1.6-1.7-1.3-1.4-1.4-1.4-1.4-1.3-1.1-1.50.1
Intermitt. access day 15 inactive lever presses0.81.62.9-1.4-1.3-1.1-1.4-1.5-1.1-1.3-1.3-1.0-1.3-1.4-1.2-1.70.4
Intermitt. access escalation Index2.43.34.42.12.01.32.11.82.12.01.71.71.81.82.01.71.2
Intermittent access day 1 total infusions0.20.30.7-0.7-0.4-0.70.20.10.40.20.30.70.40.50.50.60.8
Intermittent access day 15 total infusions0.30.41.2-1.1-0.9-0.9-0.8-0.8-0.5-0.5-0.5-0.3-0.5-0.4-0.5-0.40.1
Intermittent access terminal intake (last 3 days)1.82.44.0-2.0-1.8-1.7-1.7-1.7-1.5-1.6-1.5-1.2-1.5-1.5-1.5-1.3-0.6
Intermittent access total infusions0.91.13.3-1.8-1.7-1.6-1.1-1.1-0.7-0.9-0.8-0.4-0.8-0.7-0.7-0.5-0.0
Intermittent access day 1 locomotion0.70.93.6-1.9-1.7-1.7-0.8-0.9-0.3-0.4-0.3-0.0-0.3-0.3-0.2-0.20.8
Intermittent access day 15 total locomotion1.83.27.8-2.8-2.6-2.4-2.0-1.9-1.7-1.6-1.4-1.4-1.5-1.4-1.5-1.3-0.3
Intermittent access total locomotion3.03.611.2-3.3-3.2-3.0-2.0-1.9-1.4-1.4-1.2-1.0-1.2-1.3-1.2-1.10.3
Intermittent access standard deviation0.61.32.0-1.4-1.4-1.2-1.2-1.1-1.1-1.1-1.0-0.9-1.1-1.1-1.2-1.2-0.2
Left kidney weight0.31.43.80.50.40.41.31.31.41.11.11.91.11.21.31.90.4
Right kidney weight0.21.13.40.50.50.31.11.11.10.91.11.61.01.21.11.8-0.3
Cocaine induced anxiety0.50.71.20.60.4-0.10.81.01.10.90.90.90.90.90.81.00.7
Post-drug Anxiety0.60.71.00.80.70.40.91.00.90.80.90.90.80.80.71.00.5
Baseline Anxiety0.20.21.30.50.61.10.40.40.20.20.40.30.30.30.20.30.2
Tail length1.55.911.2-3.4-3.0-2.6-2.6-2.5-2.7-2.4-2.1-2.7-2.3-2.2-2.1-1.8-0.9
Length with tail1.88.010.2-3.1-3.0-2.6-3.0-2.8-3.2-2.9-2.6-3.0-2.8-2.7-2.7-2.1-2.8
Length without tail0.51.76.3-0.7-0.8-0.5-1.2-1.1-1.5-1.4-1.2-1.2-1.4-1.3-1.3-1.0-2.5
Times rat made contact with spout0.50.60.9-0.9-0.8-0.7-0.7-0.7-0.8-0.8-0.8-0.8-0.8-0.8-0.6-0.8-0.5
Lifetime Intake0.70.93.5-1.9-1.7-1.6-1.0-0.9-0.6-0.7-0.5-0.3-0.5-0.5-0.5-0.30.3
Liver weight, left2.74.510.7-2.6-2.6-3.3-2.0-2.3-2.0-2.0-2.0-2.0-2.0-1.9-1.9-1.6-0.6
Liver weight, right1.32.23.81.01.01.21.71.61.71.31.41.71.31.51.62.01.3
Locomotor activity0.71.15.3-0.8-0.7-1.10.60.50.90.90.90.81.01.01.11.02.3
Locomotor testing distance0.71.27.9-0.9-0.7-1.10.30.40.80.90.90.41.01.01.20.72.8
Locomotor testing rearing0.61.29.2-1.3-1.1-1.6-0.5-0.4-0.0-0.0-0.3-0.7-0.1-0.10.2-0.83.0
Locomotion in novel chamber0.00.00.10.10.0-0.30.3-0.00.3-0.0-0.20.3-0.1-0.10.10.1-0.2
Locomotion in novel chamber post-restriction2.13.47.8-1.6-1.9-1.5-1.8-1.9-1.8-2.0-1.9-1.3-1.9-2.0-1.9-1.2-2.8
Fecal boli incidents, locomotor time 10.10.10.80.30.30.3-0.3-0.4-0.3-0.1-0.2-0.5-0.1-0.2-0.2-0.4-0.9
Change in fecal boli incidents, locomotor task0.10.10.9-0.1-0.10.3-0.4-0.1-0.3-0.3-0.10.0-0.2-0.4-0.5-0.2-1.0
Time >=10cm from walls, locomotor time 11.01.12.41.21.20.61.51.21.10.80.61.30.60.91.01.00.8
Bouts of movement, locomotor time 10.10.20.80.50.40.90.20.40.30.30.30.60.30.20.10.1-0.1
Total resting periods, locomotor time 10.10.10.80.40.30.9-0.00.20.1-0.00.10.40.1-0.0-0.1-0.1-0.6
Rest time, locomotor task time 10.20.21.00.40.30.6-0.2-0.1-0.5-0.4-0.4-0.6-0.4-0.4-0.4-0.6-1.0
Distance moved, locomotor task time 10.10.20.4-0.7-0.4-0.3-0.3-0.5-0.3-0.5-0.4-0.1-0.5-0.4-0.3-0.20.1
Vertical activity count, locomotor time 10.00.10.2-0.5-0.4-0.4-0.1-0.3-0.1-0.3-0.30.3-0.3-0.2-0.2-0.0-0.1
Time >=10cm from walls, locomotor time 20.10.10.80.20.3-0.10.60.10.1-0.2-0.40.0-0.3-0.10.1-0.30.9
Bouts of movement, locomotor time 20.20.41.00.70.71.00.50.60.60.60.60.50.60.60.60.40.3
Total resting periods, locomotor time 20.40.71.40.90.91.20.70.90.80.80.90.70.80.80.80.70.5
Rest time, locomotor task time 22.53.27.22.62.62.71.81.81.41.61.61.21.51.61.51.4-0.4
Distance moved, locomotor task time 20.70.81.2-1.1-0.9-1.1-0.5-0.8-0.6-1.0-1.0-0.6-1.0-0.9-0.7-1.01.0
Vertical activity count, locomotor time 21.42.03.8-1.9-1.7-1.9-1.2-1.4-1.1-1.3-1.3-1.0-1.3-1.3-1.2-1.41.0
Light reinforcement 10.51.22.30.40.60.90.70.81.01.31.51.21.51.31.21.40.4
Light reinforcement 20.10.20.80.00.20.60.10.20.10.30.70.30.40.40.30.8-0.9
Bone: marrow area15.032.738.4-6.2-6.0-6.1-5.8-6.0-5.8-5.9-6.1-5.8-5.9-5.8-5.4-5.5-2.8
Bone: maximum diameter3.36.210.3-3.1-3.2-3.1-2.5-2.6-2.4-2.4-2.3-2.0-2.3-2.3-2.4-1.6-2.2
Bone: maximum force0.61.13.5-1.8-1.9-1.3-1.0-0.8-0.6-0.8-0.60.1-0.6-0.8-0.80.3-1.4
Bone: maximum moment0.71.23.9-1.8-2.0-1.5-1.1-0.8-0.6-0.9-0.70.0-0.7-0.9-0.90.1-1.4
Mean time between licks in bursts0.20.52.6-0.4-0.40.2-0.7-0.6-0.8-0.8-0.6-0.5-0.7-0.7-0.7-0.4-1.6
Mean num. licks in bursts0.20.20.4-0.6-0.50.1-0.6-0.4-0.5-0.6-0.5-0.2-0.5-0.6-0.5-0.5-0.5
Cd content in liver0.30.31.61.31.00.90.10.20.00.1-0.1-0.3-0.1-0.3-0.4-0.6-0.2
Co content in liver0.40.51.21.11.10.50.80.50.60.60.70.30.60.60.50.30.7
Cu content in liver0.30.40.7-0.5-0.5-0.3-0.7-0.6-0.7-0.6-0.6-0.7-0.6-0.6-0.6-0.8-0.8
Fe content in liver0.20.21.1-0.4-0.4-1.10.30.20.30.30.10.00.10.30.40.21.0
K content in liver0.20.20.9-0.4-0.4-0.8-0.3-0.5-0.5-0.3-0.3-0.5-0.3-0.3-0.3-0.1-0.9
Mg content in liver0.10.10.40.50.50.20.20.1-0.00.20.2-0.20.10.10.00.0-0.6
Mn content in liver0.20.20.60.1-0.1-0.50.50.40.50.40.40.50.40.40.30.8-0.3
Na content in liver0.20.20.70.00.1-0.80.2-0.00.20.50.4-0.20.50.50.50.30.6
Rb content in liver1.61.83.01.51.30.61.71.61.51.51.41.31.41.31.31.40.8
Se content in liver2.12.43.91.31.21.21.61.61.61.71.81.61.71.81.72.00.2
Sr content in liver0.40.40.6-0.7-0.6-0.6-0.5-0.7-0.7-0.7-0.6-0.5-0.7-0.7-0.7-0.5-0.3
Zn content in liver0.40.50.90.90.80.90.80.70.60.60.60.60.50.60.60.8-0.2
Bone: minimum diameter10.318.826.8-5.2-5.2-4.8-4.8-4.6-4.3-4.2-4.1-3.9-4.1-4.2-4.1-3.5-2.9
Time in familiar zone, hab. session 12.12.02.7-1.2-1.3-1.0-1.7-1.4-1.5-1.4-1.5-1.3-1.4-1.5-1.5-1.6-1.5
Time in novel zone, hab. session 12.12.12.91.21.31.21.71.51.61.51.41.51.41.51.41.51.7
Total zone transitions, hab. session 10.10.20.4-0.6-0.5-0.40.10.10.40.20.20.70.30.20.30.50.6
Total locomotion distance, hab. session 10.10.21.2-1.1-0.9-0.6-0.2-0.10.1-0.2-0.10.4-0.1-0.10.10.40.4
Locomotion velocity, hab. session 10.20.31.5-1.2-1.1-0.7-0.5-0.4-0.3-0.6-0.4-0.0-0.4-0.4-0.20.00.0
Time in familiar zone, hab. session 22.02.13.2-1.6-1.6-1.8-1.5-1.6-1.4-1.3-1.4-1.4-1.4-1.5-1.3-1.6-0.0
Time in novel zone, hab. session 21.31.33.01.31.31.71.21.31.00.80.91.10.90.90.91.3-0.5
Total zone transitions, hab. session 20.10.10.6-0.20.0-0.10.30.10.30.20.20.50.20.20.50.30.8
Total locomotion distance, hab. session 20.10.20.7-0.9-0.7-0.2-0.6-0.4-0.3-0.4-0.20.1-0.3-0.3-0.2-0.0-0.4
Locomotion velocity, hab. session 20.10.20.6-0.7-0.6-0.0-0.5-0.3-0.3-0.4-0.20.1-0.3-0.3-0.20.0-0.6
Novel to familiar place preference ratio0.40.51.2-0.9-1.1-1.0-0.6-0.5-0.6-0.6-0.5-0.4-0.6-0.6-0.7-0.3-0.5
Novelty place preference0.20.20.7-0.7-0.8-0.8-0.3-0.3-0.4-0.4-0.3-0.2-0.4-0.4-0.5-0.1-0.2
Time in novel zone, NPP test0.10.10.6-0.6-0.7-0.8-0.1-0.2-0.2-0.3-0.2-0.0-0.3-0.2-0.3-0.00.1
Total zone transitions, NPP test0.50.71.90.00.10.40.60.70.90.81.01.30.90.91.01.40.3
Total locomotion distance, NPP test0.20.31.2-1.1-1.0-0.5-0.5-0.4-0.3-0.5-0.40.1-0.4-0.5-0.3-0.0-0.3
Locomotion velocity, NPP test0.10.10.4-0.7-0.50.2-0.3-0.0-0.0-0.10.10.50.1-0.00.10.4-0.6
Intraocular pressure0.20.31.60.10.71.30.30.40.20.40.50.40.50.60.80.50.1
Delta distance traveled before/after self-admin0.30.42.5-0.2-0.1-0.30.40.40.60.50.50.30.60.50.60.51.6
Delta ambulatory time before/after self-admin0.10.10.3-0.5-0.5-0.5-0.3-0.1-0.1-0.1-0.0-0.3-0.0-0.10.0-0.00.5
Parametrial fat weight0.92.18.0-0.4-0.6-0.2-1.2-1.3-1.5-1.5-1.6-1.1-1.6-1.6-1.8-1.2-2.8
Pavlov. Cond. lever latency0.40.52.10.70.81.4-0.00.0-0.3-0.4-0.4-0.3-0.3-0.5-0.6-0.4-1.5
Pavlov. Cond. magazine entry latency0.81.03.7-1.5-1.4-1.9-1.0-1.0-0.9-0.7-0.6-0.9-0.7-0.6-0.4-0.60.4
Pavlov. Cond. change in total contacts0.70.73.6-1.3-1.2-1.9-0.7-0.6-0.4-0.2-0.1-0.5-0.2-0.1-0.0-0.41.3
Pavlov. Cond. index score0.50.73.7-1.3-1.3-1.9-0.7-0.7-0.5-0.3-0.2-0.5-0.4-0.2-0.0-0.30.7
Pavlov. Cond. latency score0.40.53.3-1.2-1.2-1.8-0.4-0.5-0.3-0.1-0.0-0.3-0.2-0.00.2-0.00.9
Pavlov. Cond. lever contacts0.40.52.8-1.0-1.0-1.7-0.4-0.5-0.2-0.1-0.1-0.3-0.1-0.00.1-0.31.2
Pavlov. Cond. magazine entry number0.40.52.51.01.01.60.60.70.50.30.20.60.30.20.10.4-0.6
Pavlov. Cond. intertrial magazine entries0.40.41.4-1.2-1.2-0.4-1.2-0.7-0.4-0.2-0.2-0.0-0.1-0.4-0.5-0.1-0.8
Pavlov. Cond. lever-magazine prob. diff.0.50.63.4-1.3-1.3-1.9-0.6-0.6-0.5-0.3-0.2-0.5-0.3-0.2-0.0-0.20.5
Pavlov. Cond. response bias0.60.83.9-1.4-1.4-2.0-0.8-0.9-0.6-0.4-0.4-0.7-0.5-0.4-0.2-0.50.5
Pavlov. Cond. lever latency0.10.10.80.50.60.90.20.20.00.00.00.1-0.0-0.1-0.1-0.1-0.5
Pavlov. Cond. magazine entry latency1.62.03.41.81.91.31.91.51.31.31.21.01.21.41.41.30.7
Pavlov. Cond. change in total contacts0.30.41.8-0.8-0.8-1.3-0.6-0.7-0.4-0.3-0.4-0.8-0.4-0.3-0.2-0.50.6
Pavlov. Cond. index score0.10.20.80.20.2-0.40.50.30.40.40.30.10.30.50.60.40.9
Pavlov. Cond. latency score0.30.41.20.40.4-0.30.80.50.60.60.40.30.50.70.80.61.1
Pavlov. Cond. lever contacts0.10.10.4-0.4-0.4-0.60.00.10.20.20.20.10.30.30.40.30.6
Pavlov. Cond. magazine entry number2.83.45.3-2.2-2.2-1.4-2.3-1.9-1.9-1.8-1.6-1.5-1.7-1.9-1.9-1.8-1.4
Pavlov. Cond. intertrial magazine entries9.814.818.5-4.3-4.1-3.0-4.3-4.1-4.2-4.1-3.7-3.5-3.8-3.9-3.8-3.7-3.1
Pavlov. Cond. lever-magazine prob. diff.0.20.20.60.30.2-0.30.60.40.40.40.30.20.40.50.60.50.8
Pavlov. Cond. response bias0.10.10.2-0.1-0.2-0.50.20.20.30.30.20.20.30.40.40.40.4
Time in closed arm before self-admin0.50.72.6-0.1-0.0-0.20.90.70.90.70.70.80.70.90.90.81.6
Time in closed arm after self-admin0.10.10.3-0.00.1-0.20.50.10.0-0.2-0.40.0-0.3-0.2-0.1-0.10.3
Time in open arm before self-admin0.80.91.91.41.41.01.21.00.90.90.70.90.70.70.90.80.4
Time in open arm after self-admin0.10.10.30.40.40.6-0.20.0-0.10.10.2-0.30.10.20.10.1-0.5
Bone: periosteal estimation7.115.123.2-4.8-4.8-4.8-4.0-4.1-3.7-3.8-3.8-3.4-3.7-3.8-3.6-3.1-2.1
Bone: periosteal perimeter3.05.110.4-2.8-3.0-3.2-2.3-2.4-2.1-2.1-2.0-1.8-2.1-2.0-2.1-1.3-1.6
Bone: post-yield work1.72.43.5-1.9-1.9-1.9-1.5-1.6-1.4-1.6-1.7-1.4-1.6-1.6-1.4-1.3-0.6
Progressive ratio test 1 active lever presses0.40.52.2-1.5-1.4-1.2-0.6-0.6-0.2-0.2-0.10.0-0.1-0.1-0.10.10.4
Progressive ratio test 1 breakpoint0.50.62.8-1.7-1.5-1.3-0.8-0.7-0.4-0.4-0.2-0.2-0.3-0.3-0.3-0.10.3
Progressive ratio test 1 inactive lever presses1.11.65.2-2.3-2.2-2.1-1.1-1.3-0.6-0.8-0.9-0.3-0.8-0.9-0.7-0.60.7
Progressive ratio test 2 active lever presses1.31.53.3-1.8-1.6-1.3-1.4-1.4-1.3-1.1-0.9-1.0-1.0-0.9-1.0-0.7-0.9
Progressive ratio test 2 breakpoint1.61.83.8-1.9-1.7-1.4-1.6-1.5-1.4-1.2-1.1-1.1-1.1-1.0-1.1-0.9-1.0
Progressive ratio test 2 inactive lever presses0.40.72.6-1.6-1.5-0.9-1.1-1.0-0.6-0.6-0.5-0.1-0.6-0.6-0.6-0.4-0.3
Incentive Sensitization - Responses1.11.62.2-1.4-1.2-1.0-1.4-1.5-1.5-1.3-1.2-1.1-1.2-1.1-1.1-1.0-1.4
Incentive Sensitization - Breakpoint1.31.72.4-1.4-1.2-1.0-1.4-1.5-1.5-1.4-1.3-1.2-1.3-1.2-1.2-1.1-1.4
Sum of active levers in priming session hrs 5-62.52.43.61.41.40.81.31.31.71.91.71.11.81.71.81.31.9
Progressive ratio0.30.53.0-0.1-0.2-0.2-0.6-0.6-0.6-0.6-0.6-0.5-0.6-0.7-0.8-0.4-1.7
Food seeking constrained by brief footshock4.75.77.5-2.4-2.3-2.6-2.1-2.6-2.5-2.4-2.5-2.7-2.6-2.4-2.3-2.7-0.5
Seeking ratio, punishment vs. effort0.91.32.5-1.6-1.4-1.6-0.9-1.2-1.0-0.9-0.9-1.2-1.0-0.9-0.6-1.21.1
Retroperitoneal fat weight0.41.62.0-1.4-1.3-0.7-1.2-1.3-1.4-1.4-1.3-1.4-1.3-1.3-1.2-1.1-1.1
Reaction time number correct0.91.82.91.51.41.71.21.41.31.21.21.41.21.21.21.7-0.7
Reaction time mean minus median0.00.10.50.50.50.70.10.1-0.00.0-0.1-0.10.0-0.1-0.0-0.4-0.4
Reaction time mean minus median AUC0.40.91.51.21.01.21.01.01.00.90.81.21.00.80.80.8-0.3
Reaction time num false alarms1.01.44.2-1.8-1.9-2.1-1.0-1.1-1.1-0.9-0.8-1.1-1.0-0.8-0.6-0.40.2
Reaction time num false alarms AUC1.21.84.7-1.9-2.0-2.2-1.3-1.3-1.3-1.2-1.0-1.4-1.2-1.0-0.9-0.6-0.4
Reaction time trials correct on left0.91.82.91.51.41.71.21.41.31.21.21.41.21.21.21.7-0.7
Reaction time trials on left0.91.72.91.51.41.71.21.31.21.21.21.31.21.21.11.7-0.8
Reaction time mean0.20.30.80.90.80.50.60.60.70.50.30.60.40.40.40.10.4
Reaction time mean AUC0.40.61.21.11.00.60.90.80.90.80.50.70.60.60.70.20.8
Median of all reaction times0.30.50.90.90.80.50.80.70.90.70.40.90.60.60.60.40.7
Reaction time omissions0.71.02.3-0.7-0.70.0-1.0-0.9-1.0-1.2-1.2-0.8-1.1-1.2-1.2-1.0-1.5
Reaction time false alarm rate2.23.07.1-2.3-2.3-2.7-1.6-1.7-1.7-1.6-1.4-1.8-1.6-1.4-1.2-1.40.3
Reaction time premature initiation rate0.20.31.2-1.0-1.1-0.8-0.8-0.6-0.3-0.10.0-0.10.0-0.2-0.4-0.20.1
Reaction time premature initiations0.10.10.4-0.2-0.30.1-0.20.10.20.40.50.40.50.30.10.6-0.5
Std. dev. reaction times0.10.20.60.30.10.2-0.2-0.2-0.3-0.3-0.5-0.3-0.4-0.5-0.5-0.8-0.7
Reaction time trials completed0.91.72.91.51.41.71.21.31.21.21.21.31.21.21.11.7-0.8
Reaction time trials AUC0.81.52.61.41.31.61.11.21.11.11.11.31.11.11.01.5-0.8
Run reversals in cocaine runway, females0.20.21.40.70.71.20.20.40.30.10.30.40.20.10.1-0.1-0.4
Run reversals in cocaine runway, males0.00.00.20.30.30.50.0-0.00.00.10.10.30.1-0.0-0.10.0-0.3
Latency to leave start box in cocaine runway0.40.51.10.60.80.40.90.60.70.60.50.80.50.70.80.61.1
Latency to leave start box in cocaine runway, F1.72.03.81.01.20.71.71.31.41.41.41.21.31.61.61.52.0
Latency to leave start box in cocaine runway, M0.30.30.7-0.2-0.1-0.2-0.5-0.6-0.4-0.6-0.7-0.1-0.7-0.6-0.6-0.8-0.2
Std. dev. time between licks in bursts0.00.00.20.10.20.5-0.2-0.1-0.2-0.2-0.1-0.1-0.1-0.0-0.1-0.10.1
Total sessions with >9 infusions1.41.82.70.30.60.71.11.21.31.51.61.41.61.71.61.61.5
Short access day 1 total inactive lever presses0.50.62.6-1.6-1.5-1.1-0.6-0.7-0.4-0.6-0.4-0.0-0.4-0.5-0.4-0.20.8
Short access day 10 total inactive lever presses0.20.41.1-0.8-1.0-0.5-0.8-0.7-0.3-0.6-0.5-0.0-0.5-0.7-0.6-0.7-0.2
Short access day 1 total infusions1.92.53.80.20.60.41.31.41.61.71.91.71.91.92.01.91.9
Short access day 10 total infusions0.70.93.8-2.0-1.7-1.4-0.9-0.9-0.5-0.7-0.6-0.1-0.6-0.5-0.5-0.40.7
Short access total infusions0.30.41.7-1.1-0.8-0.90.00.00.40.30.40.50.40.50.50.51.3
Short access day 1 locomotion0.60.71.5-0.8-0.60.00.10.50.60.91.20.91.11.00.91.11.0
Short access day 10 total locomotion1.73.17.9-2.8-2.6-2.4-2.0-1.9-1.7-1.4-1.2-1.6-1.3-1.3-1.3-1.60.1
Short access total locomotion0.40.52.6-1.6-1.3-0.9-0.6-0.5-0.2-0.00.2-0.00.20.10.10.00.8
One hour access (0.3 mA shock)0.30.30.6-0.8-0.6-0.8-0.5-0.6-0.6-0.4-0.5-0.7-0.5-0.4-0.3-0.40.2
Compulsive drug intake0.40.51.21.01.00.51.10.70.80.70.40.60.60.50.70.70.3
One hour access (shock baseline)0.60.91.8-1.4-1.2-0.9-1.2-1.0-1.0-0.9-0.8-0.9-0.9-0.8-0.9-0.8-0.3
Social response proportion0.20.20.50.40.20.30.40.70.60.70.60.30.60.50.60.5-0.0
Social responses0.20.31.2-0.2-0.3-0.50.30.50.50.50.40.40.50.50.60.41.1
Social time0.10.10.30.50.60.3-0.0-0.1-0.10.1-0.2-0.4-0.1-0.0-0.0-0.4-0.4
Soleus weight0.20.50.90.20.0-0.10.40.50.70.81.00.80.80.90.80.90.3
Bone: stiffness0.40.72.0-1.3-1.4-1.3-0.7-0.6-0.5-0.7-0.7-0.2-0.6-0.7-0.60.1-1.1
Tibialis anterior weight0.10.20.5-0.4-0.30.1-0.7-0.5-0.6-0.4-0.1-0.2-0.3-0.4-0.4-0.7-0.2
Time to tail flick, vehicle, before self-admin0.30.31.40.20.1-0.5-0.1-0.4-0.3-0.4-0.6-0.7-0.5-0.6-0.6-0.3-1.2
Time to tail flick, vehicle, after self-admin0.20.33.30.1-0.20.3-0.30.1-0.1-0.00.10.30.0-0.0-0.20.4-1.8
Time to tail flick, test, before self-admin0.30.30.8-0.2-0.2-0.7-0.4-0.4-0.2-0.2-0.5-0.7-0.3-0.5-0.4-0.80.9
Time to tail flick, test, after self-admin0.00.00.1-0.0-0.0-0.3-0.2-0.0-0.10.10.1-0.30.0-0.0-0.0-0.0-0.2
Delta time to tail flick, vehicle, before/after SA1.31.22.0-1.2-1.3-0.5-1.4-1.1-1.2-1.2-1.0-0.9-1.1-1.1-1.1-1.1-1.2
Delta time to tail flick, test, before/after SA0.10.11.20.0-0.1-0.1-0.0-0.0-0.1-0.10.00.1-0.1-0.1-0.10.3-1.1
Tibia length0.41.23.40.50.40.61.11.21.21.01.11.51.11.11.21.8-0.1
Ambulatory time before self-admin0.40.61.21.01.00.51.10.80.70.80.60.70.70.90.80.90.3
Ambulatory time after self-admin0.20.20.80.00.1-0.30.50.40.40.50.40.00.50.50.60.50.9
Bone: tissue strength2.02.03.21.21.21.21.51.71.61.31.31.71.41.41.61.80.3
Total heroin consumption0.20.31.10.00.1-0.80.50.30.40.50.40.10.40.60.70.41.1
Bone: trabecular number0.71.22.7-1.2-1.2-1.2-1.1-1.1-1.1-1.0-0.9-0.9-0.9-1.0-1.1-0.5-1.6
Bone: trabecular spacing0.10.21.20.50.60.30.40.30.30.30.2-0.00.20.30.4-0.11.1
Bone: trabecular thickness0.81.03.3-1.1-1.2-0.7-1.2-0.9-1.1-0.9-0.6-0.8-0.8-0.9-1.0-0.5-1.8
Bone: trabecular tissue density1.62.45.11.31.11.81.41.71.61.41.52.01.51.41.32.3-0.6
Water consumed over 24 hours0.00.00.2-0.4-0.3-0.10.20.20.10.00.10.20.10.00.20.20.0
Number of responses in last shaping day0.20.20.50.10.10.30.40.50.50.50.60.40.50.50.60.50.7