Hub : Genes

Smurf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Smurf2 0.5 0.14 5.0e-10 0.32 0.31 0.32 0.31 1.8e-08 3.8e-08 1.5e-08 3.9e-08
2 OFC gene expression Smurf2 0.54 0.15 4.0e-07 0.24 0.2 0.2 0.24 2.2e-06 1.4e-05 1.9e-05 2.1e-06
3 Adipose gene expression Smurf2 0.24 0.08 0.0e+00 0.25 0.23 0.27 0.26 4.1e-27 3.7e-25 1.0e-29 6.3e-29
4 Liver gene expression Smurf2 0.2 0.06 0.0e+00 0.22 0.25 0.26 0.26 1.3e-24 9.7e-28 7.5e-29 2.5e-29
5 PL gene expression Smurf2 0.38 0.08 0.0e+00 0.54 0.56 0.58 0.58 4.0e-70 1.3e-74 5.6e-77 3.6e-77
6 pVTA gene expression Smurf2 0.48 0.12 0.0e+00 0.5 0.5 0.52 0.18 2.1e-45 1.4e-45 3.8e-48 8.1e-15
7 NAcc gene expression Smurf2 0.51 0.12 0.0e+00 0.43 0.42 0.43 0.44 2.7e-72 4.0e-70 1.5e-71 3.6e-73
8 PL mRNA stability Smurf2 0.05 0.03 4.9e-06 0.05 0.06 0.07 0.05 8.8e-06 4.0e-07 5.9e-08 1.8e-06
9 Brain mRNA stability Smurf2 0.11 0.05 1.2e-10 0.12 0.12 0.12 0.11 2.5e-11 4.1e-11 4.1e-11 1.1e-10
10 Brain gene expression Smurf2 0.64 0.09 0.0e+00 0.47 0.51 0.51 0.51 1.9e-49 3.9e-55 7.7e-55 3.0e-55
11 BLA gene expression Smurf2 0.48 0.11 0.0e+00 0.48 0.48 0.48 0.51 9.8e-29 3.3e-28 3.2e-28 8.2e-31
12 LHb gene expression Smurf2 0.4 0.12 2.7e-08 0.21 0.24 0.25 0.21 1.3e-05 2.5e-06 9.5e-07 9.2e-06
13 IC gene expression Smurf2 0.49 0.11 0.0e+00 0.43 0.41 0.47 0.46 8.3e-20 1.6e-18 3.5e-22 3.2e-21
14 NAcc mRNA stability Smurf2 0.03 0.01 4.4e-05 0.03 0.03 0.03 0.03 3.9e-05 7.6e-06 6.6e-05 1.4e-05
15 Adipose mRNA stability Smurf2 0.04 0.02 1.7e-03 -0 0.02 0.02 0 5.6e-01 5.3e-03 1.9e-03 7.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.71.70.9-1.01.0-0.8-0.80.8-0.70.60.6-0.6-0.80.80.9-0.41.3
Area under the delay curve0.20.31.9-0.40.1-0.70.00.3-0.20.4-0.5-0.40.50.3-0.2-0.20.71.4
BMI with tail0.10.42.51.6-1.20.4-0.7-0.50.3-0.3-0.1-0.20.1-0.10.30.10.1-0.4
BMI without tail0.21.26.22.5-2.00.7-1.4-1.01.0-0.80.30.7-0.4-0.51.00.5-0.10.0
Body weight1.25.112.43.5-3.22.1-2.7-2.32.4-2.21.71.9-1.8-1.92.31.8-1.31.7
Weight adjusted by age0.30.71.3-1.11.0-1.00.90.8-0.71.0-1.0-0.50.90.9-0.7-0.81.00.1
Bone surface3.77.39.83.0-3.13.1-2.5-2.82.7-2.72.72.4-2.7-2.72.52.7-2.02.5
Bone volume2.44.87.12.6-2.72.5-2.2-2.22.2-2.22.01.9-2.1-2.22.12.2-1.42.3
Breakpoint value in progressive ratio session0.30.62.9-0.51.0-0.20.90.5-0.60.7-0.5-0.30.60.8-0.7-0.90.3-1.7
Number of licking bursts0.00.00.1-0.20.20.20.30.1-0.10.2-0.20.10.20.2-0.2-0.30.20.0
Context. condit. distance diff. score0.10.10.90.1-0.20.30.0-0.0-0.20.2-0.2-0.20.10.1-0.2-0.10.2-1.0
Locomotion velocity, session 10.20.30.60.8-0.70.5-0.5-0.60.5-0.60.50.3-0.5-0.50.50.4-0.30.3
Locomotion distance, session 10.10.10.30.4-0.3-0.2-0.00.1-0.20.1-0.2-0.60.20.0-0.2-0.20.50.2
Locomotion velocity, session 20.40.42.10.8-0.51.2-0.1-0.60.3-0.40.60.6-0.5-0.40.10.1-0.6-1.4
Locomotion distance, session 20.30.41.4-0.10.3-0.10.70.4-0.70.6-0.4-0.90.50.5-0.9-0.80.7-1.2
Locomotion velocity, session 32.02.33.5-1.11.3-0.71.61.4-1.61.6-1.6-1.51.51.6-1.6-1.71.7-1.9
Locomotion distance, session 30.10.10.2-0.0-0.00.40.40.2-0.20.2-0.2-0.20.20.3-0.3-0.30.4-0.5
Stereotopy head waving bouts, day 30.81.01.6-1.21.2-1.31.01.0-0.91.0-1.1-0.91.01.0-0.8-0.91.00.0
Stereotopy head waving duration, day 31.11.32.0-1.31.4-1.41.11.2-1.11.2-1.3-1.01.21.2-1.0-1.21.30.0
Locomotion velocity, session 70.10.10.3-0.20.3-0.10.40.2-0.40.3-0.2-0.40.30.2-0.4-0.10.1-0.6
Locomotion distance, session 70.00.00.00.10.0-0.2-0.1-0.0-0.20.10.2-0.10.1-0.1-0.2-0.0-0.0-0.2
Stereotopy head waving bouts, day 72.02.33.1-1.51.6-1.01.71.4-1.51.7-1.5-1.31.51.6-1.6-1.81.4-1.6
Stereotopy head waving duration, day 72.93.54.9-2.12.1-1.12.21.8-1.92.1-1.9-1.51.92.0-2.0-2.11.6-1.8
Locomotion velocity, session 81.01.22.21.2-1.11.5-0.9-1.31.1-1.11.11.0-1.1-1.11.01.1-1.10.2
Locomotion distance, session 80.10.21.20.5-0.50.8-0.1-0.3-0.10.00.0-0.2-0.0-0.1-0.20.00.0-1.1
Degree of sensitization distance0.50.51.40.5-0.5-0.2-0.9-0.60.7-0.80.90.6-0.7-0.80.70.8-0.71.2
Degree of sensitization stereotypy2.83.26.3-1.41.5-0.71.91.6-1.91.9-1.7-1.61.81.8-2.0-2.01.5-2.5
Conditioned locomotion0.20.20.50.5-0.40.1-0.7-0.50.5-0.40.40.4-0.4-0.40.40.3-0.60.3
Cocaine response after cond. corrected0.20.31.2-0.90.8-0.90.60.5-0.30.3-0.2-0.30.20.3-0.3-0.30.51.1
Cocaine response after cond. not corrected0.30.41.1-1.10.9-0.40.90.7-0.60.6-0.4-0.30.40.5-0.6-0.60.60.2
Cocaine response before conditioning0.40.52.6-0.20.20.80.70.5-0.70.8-0.7-0.30.70.7-0.8-0.70.5-1.6
Saline control response0.30.42.30.9-0.60.8-0.7-0.50.3-0.20.20.5-0.2-0.10.2-0.1-0.7-1.5
Bone: connectivity density1.01.72.41.4-1.41.2-1.2-1.41.3-1.31.21.1-1.2-1.31.31.4-0.91.6
Bone: cortical apparent density3.35.37.1-2.32.2-2.22.32.4-2.42.4-2.6-2.72.52.3-2.2-2.02.6-0.8
Bone: cortical area0.30.52.21.3-1.51.3-0.4-0.3-0.10.0-0.3-0.70.20.0-0.20.20.70.0
Bone: cortical porosity2.02.27.01.9-1.92.6-1.3-1.61.2-1.21.41.4-1.3-1.10.90.9-1.5-0.8
Bone: cortical porosity1.01.14.81.7-1.62.2-1.0-1.10.8-0.70.70.8-0.7-0.70.50.6-0.7-0.6
Bone: cortical thickness9.315.524.5-2.92.7-2.83.84.0-4.44.2-4.6-5.04.44.2-4.2-3.74.6-2.5
Bone: cortical thickness4.55.59.2-1.51.3-1.12.22.3-2.82.5-2.6-3.02.62.4-2.7-2.12.5-2.6
Bone: cortical tissue density3.25.16.6-2.32.2-2.22.32.4-2.42.3-2.5-2.62.42.2-2.2-1.92.5-0.9
Condit. Reinf. active minus inactive responses0.70.82.01.3-1.31.4-1.1-1.00.6-0.50.60.6-0.5-0.60.40.4-0.8-0.9
Condit. Reinf. active-inactive response ratio0.30.40.90.6-0.61.0-0.7-0.70.4-0.30.50.6-0.4-0.40.30.4-0.6-0.9
Condit. Reinf. active responses1.11.43.61.8-1.91.9-1.6-1.41.0-0.80.80.9-0.8-0.90.70.8-1.0-0.2
Condit. Reinf. inactive responses0.81.02.31.4-1.51.2-1.2-0.90.9-0.80.60.5-0.7-0.80.80.8-0.61.4
Incentive salience index mean0.60.82.81.3-1.31.7-1.0-1.00.6-0.50.50.7-0.5-0.50.40.4-0.7-0.9
Condit. Reinf. lever presses0.20.21.70.3-0.31.0-0.1-0.1-0.10.3-0.20.10.20.3-0.3-0.3-0.1-1.3
Condit. Reinf. active minus inactive responses1.32.06.72.3-2.32.6-1.5-1.51.1-1.01.01.0-1.0-0.90.70.9-0.60.1
Condit. Reinf. active-inactive response ratio0.50.92.61.2-1.21.6-1.0-1.10.9-0.70.81.0-0.7-0.70.60.7-0.70.2
Condit. Reinf. active responses2.84.09.63.0-3.13.1-2.3-2.11.7-1.71.61.6-1.6-1.61.41.5-1.20.3
Condit. Reinf. inactive responses1.11.65.22.3-2.31.9-1.6-1.20.9-1.00.90.6-0.9-1.00.80.9-0.7-0.3
Condit. Reinf. lever presses0.71.04.51.8-1.82.1-0.9-0.90.5-0.50.50.5-0.4-0.40.20.3-0.5-1.2
Condit. Reinf. lever reinforcers received2.53.68.32.8-2.92.9-2.2-2.01.6-1.61.51.5-1.5-1.61.41.5-1.20.3
Conditioned reinforcement - actives0.00.00.10.3-0.20.1-0.20.1-0.00.1-0.30.10.20.3-0.0-0.30.2-0.3
Conditioned reinforcement - inactives0.41.02.31.5-1.31.0-1.0-1.10.8-1.11.10.6-1.0-1.00.90.9-0.9-0.2
Conditioned locomotion1.11.63.41.8-1.71.3-1.6-1.41.3-1.11.01.2-1.0-1.01.21.1-1.10.5
Patch foraging indifference point 0 sec1.02.97.32.7-2.72.0-2.2-1.91.4-1.61.30.8-1.3-1.51.31.4-1.00.8
Patch foraging indifference point AUC0.51.22.21.5-1.41.2-1.0-1.11.3-1.10.91.3-1.1-1.01.31.0-0.60.6
Delay disc. indifference point, 0s delay0.40.51.4-1.01.0-1.20.60.6-0.40.6-0.6-0.40.60.5-0.4-0.40.60.8
Delay disc. indifference point, 16s delay0.20.32.2-0.30.1-0.7-0.10.2-0.20.4-0.6-0.30.50.4-0.2-0.30.71.5
Delay disc. indifference point, 2s delay0.80.96.10.6-1.00.4-0.9-0.60.8-0.70.60.5-0.6-0.80.80.9-0.12.5
Delay disc. indifference point, 24s delay0.30.52.70.9-1.00.3-0.9-0.60.6-0.50.20.2-0.3-0.30.60.60.11.6
Delay disc. indifference point, 4s delay0.80.81.1-1.10.8-0.90.90.9-0.91.1-1.0-0.81.00.9-0.9-0.91.0-0.0
Delay disc. indifference point, 8s delay0.30.51.4-0.80.6-1.20.40.6-0.50.6-0.7-0.70.70.5-0.4-0.40.81.0
Indifference point function ln k0.61.83.2-0.90.7-0.51.11.3-1.71.5-1.5-1.81.61.4-1.7-1.31.4-1.1
Indifference point function log k0.61.83.2-0.90.7-0.51.11.3-1.71.5-1.5-1.81.61.4-1.7-1.31.4-1.1
Patch foraging total patch changes 0 sec1.13.27.62.8-2.72.0-2.3-2.01.5-1.71.50.9-1.4-1.61.41.6-1.10.9
Patch foraging total patch changes 12 sec4.76.39.13.0-2.82.2-2.8-2.72.7-2.62.52.3-2.4-2.52.62.3-2.21.5
Patch foraging total patch changes 18 sec0.81.84.42.1-1.81.4-1.5-1.41.4-1.41.31.1-1.3-1.21.21.0-1.0-0.3
Patch foraging total patch changes 24 sec0.72.35.92.4-2.41.7-1.8-1.41.5-1.41.11.0-1.2-1.21.31.3-0.61.0
Patch foraging total patch changes 6 sec1.62.76.22.5-2.52.1-1.8-1.81.5-1.71.41.1-1.4-1.61.41.5-1.10.4
Patch foraging time to switch 0 sec0.10.41.8-1.11.4-1.10.80.4-0.30.4-0.1-0.10.30.4-0.3-0.5-0.2-0.4
Patch foraging water rate 0 sec0.62.26.12.3-2.51.7-1.8-1.41.2-1.41.10.8-1.2-1.41.21.5-0.80.9
Patch foraging water rate 12 sec0.41.74.6-0.90.7-0.81.21.5-1.61.2-1.3-2.11.31.2-1.5-1.11.7-0.4
Patch foraging water rate 18 sec0.30.73.1-0.3-0.10.10.50.8-1.20.8-0.8-1.70.90.7-1.1-0.61.2-0.1
Patch foraging water rate 24 sec0.10.20.8-0.30.2-0.40.40.4-0.60.3-0.2-0.90.30.4-0.6-0.30.60.4
Patch foraging water rate 6 sec0.30.41.7-0.20.0-0.30.40.7-0.80.5-0.7-1.30.70.6-0.7-0.41.00.4
Seeking ratio, delayed vs. immediate footshock0.00.00.10.00.0-0.30.00.2-0.20.2-0.4-0.30.30.3-0.1-0.20.1-0.2
Distance traveled before self-admin0.61.31.9-1.31.4-0.81.41.2-1.11.1-1.0-0.91.11.2-1.2-1.21.2-0.4
Distance traveled after self-admin0.20.30.9-0.30.40.40.70.5-0.50.5-0.3-0.00.50.5-0.6-0.60.6-0.9
Extensor digitorum longus weight0.41.48.0-1.81.8-2.80.51.1-0.60.8-1.0-0.80.90.7-0.2-0.50.10.7
Bone: elastic displacement2.63.34.6-1.61.4-1.21.81.8-2.02.0-2.1-2.11.91.9-2.0-1.81.9-1.1
Bone: elastic work0.20.20.90.3-0.40.30.30.3-0.50.5-0.7-1.00.50.4-0.5-0.10.6-0.4
Bone: endosteal estimation13.633.339.76.3-6.16.2-5.9-6.15.8-6.06.25.9-6.0-5.95.55.4-5.52.9
Bone: endosteal perimeter13.232.439.56.3-6.26.0-5.9-6.05.9-5.85.95.7-5.8-5.75.55.4-5.13.6
Epididymis fat weight0.10.50.80.9-0.60.1-0.7-0.90.9-0.70.60.8-0.7-0.70.90.6-0.60.9
Delta time in closed arm before/after self-admin0.20.20.3-0.00.1-0.0-0.2-0.30.4-0.50.50.5-0.5-0.50.50.5-0.50.1
Delta time in open arm before/after self-admin0.20.31.1-0.60.7-1.00.20.4-0.30.5-0.60.10.50.6-0.1-0.40.40.1
Diff in mean of infusions in LGA sessions1.42.53.6-1.61.7-1.51.71.5-1.71.5-1.4-1.71.51.5-1.6-1.51.1-1.9
Delay discount exponential model param0.20.22.40.10.20.40.3-0.0-0.0-0.20.30.2-0.3-0.1-0.0-0.0-0.5-1.5
Extinction: sum of active levers before priming0.10.20.4-0.30.2-0.40.00.3-0.30.6-0.6-0.20.60.5-0.3-0.40.4-0.2
Active lever presses in extinction session 60.40.41.01.0-0.91.0-0.8-0.70.6-0.40.40.8-0.3-0.40.40.3-0.6-0.7
Bone: final force0.40.62.11.3-1.51.4-0.5-0.50.3-0.50.4-0.1-0.5-0.60.20.70.30.9
Bone: final moment0.40.62.21.3-1.51.5-0.5-0.50.3-0.50.4-0.2-0.4-0.60.20.70.30.7
Food consumed during 24 hour testing period0.61.22.31.5-1.20.7-1.3-1.21.3-1.21.01.1-1.0-1.01.30.8-1.00.5
Glucose1.42.33.0-1.71.7-1.41.71.6-1.51.4-1.4-1.51.41.6-1.5-1.61.5-0.9
Heart weight1.11.83.2-1.11.1-1.61.11.3-1.31.5-1.5-1.51.51.4-1.3-1.31.80.4
Delay discount hyperbolic model param0.20.22.50.00.30.30.30.1-0.1-0.00.20.1-0.10.0-0.2-0.1-0.3-1.6
Intermittent access intake day 1-15 change0.10.51.10.3-0.30.4-0.7-0.60.8-0.70.80.9-0.9-0.80.80.9-1.00.1
Intermittent access intake escalation0.10.81.30.7-0.70.7-1.0-0.91.0-0.80.91.0-1.0-0.90.91.0-1.10.2
Intermittent access intake escalation 21.22.03.01.1-1.01.0-1.4-1.31.6-1.41.51.7-1.5-1.51.61.6-1.70.5
Intermitt. access day 1 inactive lever presses0.22.23.81.9-1.91.9-1.6-1.71.3-1.41.41.4-1.4-1.31.31.1-1.5-0.1
Intermitt. access day 15 inactive lever presses0.31.62.91.4-1.31.1-1.4-1.51.1-1.31.31.0-1.3-1.41.11.2-1.7-0.4
Intermitt. access escalation Index1.13.44.8-2.12.0-1.32.11.8-2.12.0-1.7-1.71.81.8-2.2-2.01.7-1.2
Intermittent access day 1 total infusions0.10.30.70.7-0.40.70.20.1-0.40.2-0.3-0.70.40.5-0.5-0.50.6-0.9
Intermittent access day 15 total infusions0.20.41.21.1-0.90.9-0.8-0.80.5-0.50.50.3-0.5-0.40.50.5-0.4-0.1
Intermittent access terminal intake (last 3 days)1.42.44.02.0-1.81.7-1.7-1.71.5-1.61.51.2-1.5-1.51.51.5-1.30.6
Intermittent access total infusions0.91.03.31.8-1.71.6-1.1-1.10.7-0.90.80.4-0.8-0.70.70.7-0.50.0
Intermittent access day 1 locomotion0.40.83.61.9-1.71.7-0.8-0.90.3-0.40.30.0-0.3-0.30.20.2-0.2-0.9
Intermittent access day 15 total locomotion0.83.27.82.8-2.62.4-2.0-1.91.7-1.61.41.4-1.5-1.41.61.5-1.30.3
Intermittent access total locomotion2.93.511.23.3-3.23.0-2.0-1.91.4-1.41.21.0-1.2-1.31.21.2-1.1-0.3
Intermittent access standard deviation0.21.32.01.4-1.41.2-1.2-1.11.1-1.11.00.9-1.1-1.11.21.2-1.20.2
Left kidney weight0.21.53.8-0.50.4-0.41.31.3-1.41.1-1.1-1.91.11.2-1.5-1.31.9-0.4
Right kidney weight0.21.13.4-0.50.5-0.31.11.1-1.10.9-1.1-1.61.01.2-1.1-1.11.80.3
Cocaine induced anxiety0.30.71.3-0.60.40.10.81.0-1.10.9-0.9-0.90.90.9-1.1-0.81.0-0.7
Post-drug Anxiety0.60.71.0-0.80.7-0.40.91.0-0.90.8-0.9-0.90.80.8-0.9-0.71.0-0.5
Baseline Anxiety0.10.21.3-0.50.6-1.10.40.4-0.20.2-0.4-0.30.30.3-0.0-0.20.3-0.2
Tail length1.15.911.23.4-3.02.6-2.6-2.52.7-2.42.12.7-2.3-2.22.52.1-1.80.9
Length with tail1.88.010.23.1-3.02.6-3.0-2.83.2-2.92.63.0-2.8-2.73.12.7-2.12.8
Length without tail0.31.86.40.7-0.80.5-1.2-1.11.5-1.41.21.2-1.4-1.31.51.3-1.02.5
Times rat made contact with spout0.50.60.90.9-0.80.7-0.7-0.70.8-0.80.80.8-0.8-0.80.80.6-0.80.5
Lifetime Intake0.70.93.51.9-1.71.6-1.0-0.90.6-0.70.50.3-0.5-0.50.50.5-0.3-0.3
Liver weight, left2.64.410.72.6-2.63.3-2.0-2.32.0-2.02.02.0-2.0-1.91.81.9-1.60.6
Liver weight, right1.32.23.8-1.01.0-1.21.71.6-1.71.3-1.4-1.71.31.5-1.6-1.62.0-1.3
Locomotor activity0.71.25.30.8-0.71.10.60.5-0.90.9-0.9-0.81.01.0-1.2-1.11.0-2.3
Locomotor testing distance0.51.28.00.9-0.71.10.30.4-0.80.9-0.9-0.41.01.0-1.1-1.20.7-2.8
Locomotor testing rearing0.31.19.21.3-1.11.6-0.5-0.40.0-0.00.30.7-0.1-0.1-0.2-0.2-0.8-3.0
Locomotion in novel chamber0.00.00.1-0.10.00.30.3-0.0-0.3-0.00.2-0.3-0.1-0.1-0.3-0.10.10.2
Locomotion in novel chamber post-restriction1.13.47.81.6-1.91.5-1.8-1.91.8-2.01.91.3-1.9-2.01.71.9-1.22.8
Fecal boli incidents, locomotor time 10.10.10.8-0.30.3-0.3-0.3-0.40.3-0.10.20.5-0.1-0.20.30.2-0.40.9
Change in fecal boli incidents, locomotor task0.10.10.90.1-0.1-0.3-0.4-0.10.3-0.30.1-0.0-0.2-0.40.40.5-0.21.0
Time >=10cm from walls, locomotor time 10.91.12.4-1.21.2-0.61.51.2-1.10.8-0.6-1.30.60.9-1.1-1.01.0-0.8
Bouts of movement, locomotor time 10.10.20.8-0.50.4-0.90.20.4-0.30.3-0.3-0.60.30.2-0.2-0.10.10.1
Total resting periods, locomotor time 10.10.10.8-0.40.3-0.9-0.00.2-0.1-0.0-0.1-0.40.1-0.00.00.1-0.10.6
Rest time, locomotor task time 10.10.21.0-0.40.3-0.6-0.2-0.10.5-0.40.40.6-0.4-0.40.50.4-0.61.0
Distance moved, locomotor task time 10.10.20.40.7-0.40.3-0.3-0.50.3-0.50.40.1-0.5-0.40.40.3-0.2-0.1
Vertical activity count, locomotor time 10.00.10.20.5-0.40.4-0.1-0.30.1-0.30.3-0.3-0.3-0.20.10.2-0.00.1
Time >=10cm from walls, locomotor time 20.00.10.8-0.20.30.10.60.1-0.1-0.20.4-0.0-0.3-0.1-0.1-0.1-0.3-0.9
Bouts of movement, locomotor time 20.10.41.0-0.70.7-1.00.50.6-0.60.6-0.6-0.50.60.6-0.4-0.60.4-0.3
Total resting periods, locomotor time 20.20.71.4-0.90.9-1.20.70.9-0.80.8-0.9-0.70.80.8-0.6-0.80.7-0.5
Rest time, locomotor task time 21.93.17.2-2.62.6-2.71.81.8-1.41.6-1.6-1.21.51.6-1.3-1.51.40.4
Distance moved, locomotor task time 20.60.81.21.1-0.91.1-0.5-0.80.6-1.01.00.6-1.0-0.90.60.7-1.0-1.0
Vertical activity count, locomotor time 20.81.93.81.9-1.71.9-1.2-1.41.1-1.31.31.0-1.3-1.31.01.2-1.4-1.0
Light reinforcement 10.31.22.3-0.40.6-0.90.70.8-1.01.3-1.5-1.21.51.3-1.0-1.21.4-0.4
Light reinforcement 20.10.20.8-0.00.2-0.60.10.2-0.10.3-0.7-0.30.40.40.0-0.30.80.9
Bone: marrow area13.332.538.46.2-6.06.1-5.8-6.05.8-5.96.15.8-5.9-5.85.45.4-5.52.8
Bone: maximum diameter3.06.110.33.1-3.23.1-2.5-2.62.4-2.42.32.0-2.3-2.32.22.4-1.62.2
Bone: maximum force0.51.03.51.8-1.91.3-1.0-0.80.6-0.80.6-0.1-0.6-0.80.50.80.31.4
Bone: maximum moment0.61.13.91.8-2.01.5-1.1-0.80.6-0.90.7-0.0-0.7-0.90.50.90.11.4
Mean time between licks in bursts0.10.52.60.4-0.4-0.2-0.7-0.60.8-0.80.60.5-0.7-0.70.80.7-0.41.6
Mean num. licks in bursts0.10.20.40.6-0.5-0.1-0.6-0.40.5-0.60.50.2-0.5-0.60.60.5-0.50.5
Cd content in liver0.30.31.6-1.31.0-0.90.10.2-0.00.10.10.3-0.1-0.30.20.4-0.60.2
Co content in liver0.40.51.2-1.11.1-0.50.80.5-0.60.6-0.7-0.30.60.6-0.5-0.50.3-0.7
Cu content in liver0.30.40.70.5-0.50.3-0.7-0.60.7-0.60.60.7-0.6-0.60.70.6-0.80.8
Fe content in liver0.20.21.10.4-0.41.10.30.2-0.30.3-0.1-0.00.10.3-0.4-0.40.2-1.0
K content in liver0.20.20.90.4-0.40.8-0.3-0.50.5-0.30.30.5-0.3-0.30.40.3-0.10.9
Mg content in liver0.10.10.4-0.50.5-0.20.20.10.00.2-0.20.20.10.10.1-0.00.00.6
Mn content in liver0.20.20.6-0.1-0.10.50.50.4-0.50.4-0.4-0.50.40.4-0.5-0.30.80.3
Na content in liver0.10.20.7-0.00.10.80.2-0.0-0.20.5-0.40.20.50.5-0.3-0.50.3-0.6
Rb content in liver1.61.93.0-1.51.3-0.61.71.6-1.51.5-1.4-1.31.41.3-1.5-1.31.4-0.8
Se content in liver2.12.43.9-1.31.2-1.21.61.6-1.61.7-1.8-1.61.71.8-1.6-1.72.0-0.2
Sr content in liver0.50.40.60.7-0.60.6-0.5-0.70.7-0.70.60.5-0.7-0.70.80.7-0.50.3
Zn content in liver0.40.50.9-0.90.8-0.90.80.7-0.60.6-0.6-0.60.50.6-0.6-0.60.80.2
Bone: minimum diameter9.718.626.85.2-5.24.8-4.8-4.64.3-4.24.13.9-4.1-4.24.14.1-3.52.9
Time in familiar zone, hab. session 11.82.02.71.2-1.31.0-1.7-1.41.5-1.41.51.3-1.4-1.51.41.5-1.61.5
Time in novel zone, hab. session 11.92.12.9-1.21.3-1.21.71.5-1.61.5-1.4-1.51.41.5-1.4-1.41.5-1.7
Total zone transitions, hab. session 10.10.20.40.6-0.50.40.10.1-0.40.2-0.2-0.70.30.2-0.4-0.30.5-0.6
Total locomotion distance, hab. session 10.10.21.21.1-0.90.6-0.2-0.1-0.1-0.20.1-0.4-0.1-0.1-0.1-0.10.4-0.5
Locomotion velocity, hab. session 10.20.31.51.2-1.10.7-0.5-0.40.3-0.60.40.0-0.4-0.40.30.20.0-0.1
Time in familiar zone, hab. session 21.82.03.21.6-1.61.8-1.5-1.61.4-1.31.41.4-1.4-1.51.21.3-1.60.0
Time in novel zone, hab. session 21.11.23.0-1.31.3-1.71.21.3-1.00.8-0.9-1.10.90.9-0.8-0.91.30.5
Total zone transitions, hab. session 20.10.10.60.20.00.10.30.1-0.30.2-0.2-0.50.20.2-0.4-0.50.3-0.8
Total locomotion distance, hab. session 20.10.20.70.9-0.70.2-0.6-0.40.3-0.40.2-0.1-0.3-0.30.30.2-0.00.4
Locomotion velocity, hab. session 20.10.10.60.7-0.60.0-0.5-0.30.3-0.40.2-0.1-0.3-0.30.40.20.00.6
Novel to familiar place preference ratio0.30.51.20.9-1.11.0-0.6-0.50.6-0.60.50.4-0.6-0.60.60.7-0.30.5
Novelty place preference0.20.20.70.7-0.80.8-0.3-0.30.4-0.40.30.2-0.4-0.40.40.5-0.10.2
Time in novel zone, NPP test0.10.10.60.6-0.70.8-0.1-0.20.2-0.30.20.0-0.3-0.20.20.3-0.0-0.1
Total zone transitions, NPP test0.50.71.9-0.00.1-0.40.60.7-0.90.8-1.0-1.30.90.9-1.0-1.01.4-0.3
Total locomotion distance, NPP test0.20.31.21.1-1.00.5-0.5-0.40.3-0.50.4-0.1-0.4-0.50.30.3-0.00.3
Locomotion velocity, NPP test0.10.10.40.7-0.5-0.2-0.3-0.00.0-0.1-0.1-0.50.1-0.00.0-0.10.40.5
Intraocular pressure0.20.31.6-0.10.7-1.30.30.4-0.20.4-0.5-0.40.50.6-0.2-0.80.5-0.1
Delta distance traveled before/after self-admin0.30.42.60.2-0.10.30.40.4-0.60.5-0.5-0.30.60.5-0.6-0.60.5-1.6
Delta ambulatory time before/after self-admin0.00.10.30.5-0.50.5-0.3-0.10.1-0.10.00.3-0.0-0.10.1-0.0-0.0-0.5
Parametrial fat weight0.92.28.00.4-0.60.2-1.2-1.31.5-1.51.61.1-1.6-1.61.61.8-1.22.8
Pavlov. Cond. lever latency0.40.52.2-0.70.8-1.4-0.00.00.3-0.40.40.3-0.3-0.50.50.6-0.41.5
Pavlov. Cond. magazine entry latency0.71.03.71.5-1.41.9-1.0-1.00.9-0.70.60.9-0.7-0.60.70.4-0.6-0.4
Pavlov. Cond. change in total contacts0.60.73.61.3-1.21.9-0.7-0.60.4-0.20.10.5-0.2-0.10.20.0-0.4-1.3
Pavlov. Cond. index score0.50.63.71.3-1.31.9-0.7-0.70.5-0.30.20.5-0.4-0.20.30.0-0.3-0.7
Pavlov. Cond. latency score0.40.53.31.2-1.21.8-0.4-0.50.3-0.10.00.3-0.2-0.00.1-0.2-0.0-0.9
Pavlov. Cond. lever contacts0.40.52.81.0-1.01.7-0.4-0.50.2-0.10.10.3-0.1-0.0-0.0-0.1-0.3-1.2
Pavlov. Cond. magazine entry number0.40.52.5-1.01.0-1.60.60.7-0.50.3-0.2-0.60.30.2-0.4-0.10.40.6
Pavlov. Cond. intertrial magazine entries0.30.41.41.2-1.20.4-1.2-0.70.4-0.20.20.0-0.1-0.40.30.5-0.10.7
Pavlov. Cond. lever-magazine prob. diff.0.50.63.41.3-1.31.9-0.6-0.60.5-0.30.20.5-0.3-0.20.30.0-0.2-0.5
Pavlov. Cond. response bias0.60.83.91.4-1.42.0-0.8-0.90.6-0.40.40.7-0.5-0.40.40.2-0.5-0.5
Pavlov. Cond. lever latency0.10.10.8-0.50.6-0.90.20.2-0.00.0-0.0-0.1-0.0-0.10.10.1-0.10.5
Pavlov. Cond. magazine entry latency1.42.03.4-1.81.9-1.31.91.5-1.31.3-1.2-1.01.21.4-1.4-1.41.3-0.7
Pavlov. Cond. change in total contacts0.20.41.80.8-0.81.3-0.6-0.70.4-0.30.40.8-0.4-0.30.30.2-0.5-0.6
Pavlov. Cond. index score0.10.20.8-0.20.20.40.50.3-0.40.4-0.3-0.10.30.5-0.5-0.60.4-0.9
Pavlov. Cond. latency score0.20.41.2-0.40.40.30.80.5-0.60.6-0.4-0.30.50.7-0.8-0.80.6-1.1
Pavlov. Cond. lever contacts0.10.10.40.4-0.40.60.00.1-0.20.2-0.2-0.10.30.3-0.3-0.40.3-0.6
Pavlov. Cond. magazine entry number2.63.45.32.2-2.21.4-2.3-1.91.9-1.81.61.5-1.7-1.91.91.9-1.81.4
Pavlov. Cond. intertrial magazine entries6.814.918.54.3-4.13.0-4.3-4.14.2-4.13.73.5-3.8-3.94.13.8-3.73.1
Pavlov. Cond. lever-magazine prob. diff.0.10.20.6-0.30.20.30.60.4-0.40.4-0.3-0.20.40.5-0.6-0.60.5-0.8
Pavlov. Cond. response bias0.10.10.20.1-0.20.50.20.2-0.30.3-0.2-0.20.30.4-0.4-0.40.4-0.4
Time in closed arm before self-admin0.40.72.60.1-0.00.20.90.7-0.90.7-0.7-0.80.70.9-1.0-0.90.8-1.6
Time in closed arm after self-admin0.00.10.30.00.10.20.50.1-0.0-0.20.4-0.0-0.3-0.2-0.10.1-0.1-0.3
Time in open arm before self-admin0.80.91.9-1.41.4-1.01.21.0-0.90.9-0.7-0.90.70.7-0.9-0.90.8-0.4
Time in open arm after self-admin0.10.10.3-0.40.4-0.6-0.20.00.10.1-0.20.30.10.20.2-0.10.10.5
Bone: periosteal estimation6.214.923.24.8-4.84.8-4.0-4.13.7-3.83.83.4-3.7-3.83.43.6-3.12.1
Bone: periosteal perimeter2.55.010.42.8-3.03.2-2.3-2.42.1-2.12.01.8-2.1-2.01.92.1-1.31.6
Bone: post-yield work1.42.43.51.9-1.91.9-1.5-1.61.4-1.61.71.4-1.6-1.61.31.4-1.30.6
Progressive ratio test 1 active lever presses0.20.42.21.5-1.41.2-0.6-0.60.2-0.20.1-0.0-0.1-0.10.20.10.1-0.4
Progressive ratio test 1 breakpoint0.30.62.81.7-1.51.3-0.8-0.70.4-0.40.20.2-0.3-0.30.40.3-0.1-0.3
Progressive ratio test 1 inactive lever presses0.61.55.22.3-2.22.1-1.1-1.30.6-0.80.90.3-0.8-0.90.50.7-0.6-0.7
Progressive ratio test 2 active lever presses1.01.53.31.8-1.61.3-1.5-1.41.3-1.10.91.0-1.0-0.91.21.0-0.70.9
Progressive ratio test 2 breakpoint1.41.83.81.9-1.71.4-1.6-1.51.4-1.21.11.1-1.1-1.01.41.1-0.91.0
Progressive ratio test 2 inactive lever presses0.20.72.61.6-1.50.9-1.1-1.00.6-0.60.50.1-0.6-0.60.60.6-0.40.3
Incentive Sensitization - Responses0.61.62.21.4-1.21.0-1.4-1.51.5-1.31.21.1-1.2-1.11.41.1-1.01.4
Incentive Sensitization - Breakpoint0.81.72.41.4-1.21.0-1.4-1.51.5-1.41.31.2-1.3-1.21.41.2-1.11.4
Sum of active levers in priming session hrs 5-62.52.43.6-1.41.4-0.81.31.3-1.71.9-1.7-1.11.81.7-1.6-1.81.3-1.9
Progressive ratio0.20.53.10.1-0.20.2-0.6-0.60.6-0.60.60.5-0.6-0.70.70.8-0.41.7
Food seeking constrained by brief footshock4.55.77.52.4-2.32.6-2.1-2.62.5-2.42.52.7-2.6-2.42.32.3-2.70.5
Seeking ratio, punishment vs. effort0.61.32.51.6-1.41.6-0.9-1.21.0-0.90.91.2-1.0-0.90.80.6-1.2-1.1
Retroperitoneal fat weight0.41.62.11.4-1.30.7-1.2-1.31.4-1.41.31.4-1.3-1.31.41.2-1.11.1
Reaction time number correct0.51.82.9-1.51.4-1.71.21.4-1.31.2-1.2-1.41.21.2-1.2-1.21.70.7
Reaction time mean minus median0.00.10.5-0.50.5-0.70.10.10.00.00.10.10.0-0.10.10.0-0.40.4
Reaction time mean minus median AUC0.10.91.5-1.21.0-1.21.01.0-1.00.9-0.8-1.21.00.8-1.0-0.80.80.3
Reaction time num false alarms0.81.34.21.8-1.92.1-1.0-1.11.1-0.90.81.1-1.0-0.80.80.6-0.4-0.2
Reaction time num false alarms AUC0.81.84.71.9-2.02.2-1.3-1.31.3-1.21.01.4-1.2-1.11.10.9-0.60.4
Reaction time trials correct on left0.51.82.9-1.51.4-1.71.21.4-1.31.2-1.2-1.41.21.2-1.2-1.21.70.7
Reaction time trials on left0.51.62.9-1.51.4-1.71.21.3-1.21.2-1.2-1.31.21.2-1.2-1.11.70.8
Reaction time mean0.10.30.8-0.90.8-0.50.60.6-0.70.5-0.3-0.60.40.4-0.6-0.40.1-0.3
Reaction time mean AUC0.20.61.2-1.11.0-0.60.90.8-0.90.8-0.5-0.70.60.6-0.9-0.70.2-0.8
Median of all reaction times0.30.50.9-0.90.8-0.50.80.7-0.90.7-0.4-0.90.60.6-0.8-0.60.4-0.7
Reaction time omissions0.61.12.30.7-0.7-0.0-1.0-0.91.0-1.21.20.8-1.1-1.21.11.2-1.01.5
Reaction time false alarm rate2.12.97.12.3-2.32.7-1.6-1.71.7-1.61.41.8-1.6-1.41.41.2-1.4-0.3
Reaction time premature initiation rate0.20.31.21.0-1.10.8-0.8-0.60.3-0.1-0.00.10.0-0.20.30.4-0.2-0.1
Reaction time premature initiations0.00.10.40.2-0.3-0.1-0.20.1-0.20.4-0.5-0.40.50.3-0.2-0.10.60.5
Std. dev. reaction times0.10.20.6-0.30.1-0.2-0.2-0.20.3-0.30.50.3-0.4-0.50.40.5-0.80.7
Reaction time trials completed0.51.62.9-1.51.4-1.71.21.3-1.21.2-1.2-1.31.21.2-1.2-1.11.70.8
Reaction time trials AUC0.41.42.6-1.41.3-1.61.11.2-1.11.1-1.1-1.31.11.1-1.1-1.01.50.8
Run reversals in cocaine runway, females0.20.21.4-0.70.7-1.20.20.4-0.30.1-0.3-0.40.20.1-0.1-0.1-0.10.4
Run reversals in cocaine runway, males0.00.00.2-0.30.3-0.50.0-0.0-0.00.1-0.1-0.30.1-0.0-0.10.10.00.3
Latency to leave start box in cocaine runway0.40.51.1-0.60.8-0.40.90.6-0.70.6-0.5-0.80.50.7-0.7-0.80.6-1.1
Latency to leave start box in cocaine runway, F1.62.03.8-1.01.2-0.71.71.3-1.41.4-1.4-1.21.31.6-1.5-1.61.5-2.0
Latency to leave start box in cocaine runway, M0.30.30.70.2-0.10.2-0.5-0.60.4-0.60.70.1-0.7-0.60.50.6-0.80.2
Std. dev. time between licks in bursts0.00.00.2-0.10.2-0.5-0.2-0.10.2-0.20.10.1-0.1-0.00.20.1-0.1-0.1
Total sessions with >9 infusions1.41.82.7-0.30.6-0.71.11.2-1.31.5-1.6-1.41.61.7-1.3-1.61.6-1.5
Short access day 1 total inactive lever presses0.30.62.61.6-1.51.1-0.6-0.70.4-0.60.40.0-0.4-0.50.40.4-0.2-0.8
Short access day 10 total inactive lever presses0.10.41.10.8-1.00.5-0.8-0.70.3-0.60.50.0-0.5-0.70.30.6-0.70.2
Short access day 1 total infusions1.32.53.8-0.20.6-0.41.31.4-1.61.7-1.9-1.71.91.9-1.7-2.01.9-1.9
Short access day 10 total infusions0.50.93.82.0-1.71.4-0.9-0.90.5-0.70.60.1-0.6-0.50.50.5-0.4-0.7
Short access total infusions0.30.41.81.1-0.80.90.00.0-0.40.3-0.4-0.50.40.5-0.4-0.50.5-1.3
Short access day 1 locomotion0.40.71.50.8-0.6-0.00.10.5-0.60.9-1.2-0.91.11.0-0.7-0.91.1-1.0
Short access day 10 total locomotion0.83.17.92.8-2.62.4-2.0-1.91.7-1.41.21.6-1.3-1.31.51.3-1.6-0.1
Short access total locomotion0.30.42.61.6-1.30.9-0.6-0.50.2-0.0-0.20.00.20.10.2-0.10.0-0.9
One hour access (0.3 mA shock)0.20.30.60.8-0.60.8-0.5-0.60.6-0.40.50.7-0.5-0.40.60.3-0.4-0.2
Compulsive drug intake0.30.51.2-1.01.0-0.51.10.7-0.80.7-0.4-0.60.60.5-0.8-0.70.7-0.3
One hour access (shock baseline)0.41.01.81.4-1.20.9-1.2-1.01.0-0.90.80.9-0.9-0.81.10.9-0.80.3
Social response proportion0.20.20.5-0.40.2-0.30.40.7-0.60.7-0.6-0.30.60.5-0.5-0.60.50.0
Social responses0.20.31.20.2-0.30.50.30.5-0.50.5-0.4-0.40.50.5-0.6-0.60.4-1.1
Social time0.10.10.3-0.50.6-0.3-0.0-0.10.10.10.20.4-0.1-0.00.00.0-0.40.4
Soleus weight0.20.50.9-0.20.00.10.40.5-0.70.8-1.0-0.80.80.9-0.8-0.80.9-0.3
Bone: stiffness0.40.72.01.3-1.41.3-0.7-0.60.5-0.70.70.2-0.6-0.70.40.60.11.1
Tibialis anterior weight0.10.20.60.4-0.3-0.1-0.7-0.50.6-0.40.10.2-0.3-0.30.80.4-0.70.2
Time to tail flick, vehicle, before self-admin0.20.31.4-0.20.10.5-0.1-0.40.3-0.40.60.7-0.5-0.60.40.6-0.31.2
Time to tail flick, vehicle, after self-admin0.10.33.2-0.1-0.2-0.3-0.30.10.1-0.0-0.1-0.30.1-0.00.10.20.41.8
Time to tail flick, test, before self-admin0.20.20.80.2-0.20.7-0.4-0.40.2-0.20.50.7-0.3-0.50.20.4-0.8-0.9
Time to tail flick, test, after self-admin0.00.00.10.0-0.00.3-0.2-0.00.10.1-0.10.30.0-0.00.10.0-0.00.2
Delta time to tail flick, vehicle, before/after SA1.21.32.01.2-1.30.5-1.4-1.11.2-1.21.00.9-1.1-1.11.21.1-1.11.2
Delta time to tail flick, test, before/after SA0.10.11.2-0.0-0.10.1-0.0-0.00.1-0.1-0.0-0.1-0.1-0.10.10.10.31.1
Tibia length0.41.23.4-0.50.4-0.61.11.2-1.21.0-1.1-1.51.11.1-1.3-1.21.80.1
Ambulatory time before self-admin0.20.61.2-1.01.0-0.51.10.8-0.70.8-0.6-0.70.70.9-0.9-0.80.9-0.3
Ambulatory time after self-admin0.10.20.8-0.00.10.30.50.4-0.40.5-0.4-0.00.50.5-0.5-0.60.5-0.9
Bone: tissue strength2.02.13.2-1.21.2-1.21.51.7-1.61.3-1.3-1.71.41.4-1.6-1.61.8-0.4
Total heroin consumption0.20.31.1-0.00.10.80.50.3-0.40.5-0.4-0.10.40.6-0.6-0.70.4-1.0
Bone: trabecular number0.61.22.71.2-1.21.2-1.1-1.11.1-1.00.90.9-0.9-1.01.01.1-0.51.6
Bone: trabecular spacing0.10.21.2-0.50.6-0.30.40.3-0.30.3-0.20.00.20.3-0.3-0.4-0.1-1.1
Bone: trabecular thickness0.71.03.31.1-1.20.7-1.2-0.91.1-0.90.60.8-0.8-0.91.11.0-0.51.8
Bone: trabecular tissue density1.32.45.1-1.31.1-1.81.41.7-1.61.4-1.5-2.01.51.4-1.5-1.32.30.5
Water consumed over 24 hours0.00.00.20.4-0.30.10.20.2-0.10.0-0.1-0.20.10.0-0.1-0.20.2-0.0
Number of responses in last shaping day0.20.20.5-0.10.1-0.30.40.5-0.50.5-0.6-0.40.50.5-0.5-0.60.5-0.7