Hub : Genes

Smurf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Smurf2 0.53 0.13 9.8e-11 0.27 0.31 0.36 0.33 2.9e-07 4.3e-08 1.9e-09 9.2e-09
2 Adipose gene expression Smurf2 0.25 0.08 0.0e+00 0.24 0.22 0.24 0.24 8.8e-27 1.6e-24 1.6e-26 1.9e-26
3 OFC gene expression Smurf2 0.52 0.15 1.5e-07 0.16 0.23 0.2 0.22 1.2e-04 4.3e-06 1.3e-05 5.1e-06
4 Liver gene expression Smurf2 0.2 0.07 0.0e+00 0.22 0.26 0.26 0.27 1.3e-23 1.6e-28 5.9e-29 5.7e-30
5 PL gene expression Smurf2 0.4 0.08 0.0e+00 0.53 0.58 0.58 0.58 6.8e-69 2.4e-77 2.9e-77 9.0e-79
6 pVTA gene expression Smurf2 0.39 0.11 5.6e-17 0.37 0.38 0.39 0.33 9.2e-17 1.6e-17 4.6e-18 4.1e-15
7 LHb gene expression Smurf2 0.39 0.12 3.4e-08 0.27 0.25 0.23 0.28 3.2e-07 1.1e-06 3.1e-06 2.7e-07
8 NAcc mRNA stability Smurf2 0.04 0.02 5.9e-05 0.03 0.03 0.03 0.03 3.1e-04 1.0e-04 1.1e-04 3.0e-04
9 NAcc gene expression Smurf2 0.51 0.13 0.0e+00 0.4 0.41 0.41 0.41 1.6e-49 2.5e-50 8.8e-52 5.0e-51
10 Brain mRNA stability Smurf2 0.11 0.04 2.0e-10 0.11 0.1 0.11 0.1 9.1e-11 6.6e-10 4.2e-10 1.5e-09
11 BLA gene expression Smurf2 0.51 0.11 0.0e+00 0.51 0.5 0.51 0.53 3.0e-31 1.0e-30 1.6e-31 7.6e-33
12 Brain gene expression Smurf2 0.65 0.08 0.0e+00 0.49 0.53 0.53 0.53 3.6e-51 3.0e-57 4.9e-57 2.5e-57
13 PL mRNA stability Smurf2 0.06 0.03 1.8e-06 0.05 0.06 0.06 0.05 2.0e-06 5.9e-07 2.1e-07 1.8e-06
14 Adipose mRNA stability Smurf2 0.04 0.02 2.8e-03 0 0.02 0.01 0.01 1.3e-01 6.5e-03 2.4e-02 5.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.71.22.31.41.5-1.3-1.0-1.11.2-1.0-0.71.00.8-1.1-1.1-0.8-1.3
Area under the delay curve0.20.21.4-0.2-0.30.3-0.00.1-0.1-0.10.4-0.3-0.20.30.2-0.6-1.2
BMI with tail0.31.03.1-0.1-0.50.80.70.8-0.70.80.9-0.6-1.81.41.1-1.7-0.5
BMI without tail0.30.62.81.20.7-0.4-0.6-0.50.4-0.5-0.20.4-0.60.50.1-1.7-1.4
Body weight0.83.47.52.72.2-2.1-1.9-1.91.9-1.8-1.31.70.8-1.1-1.4-2.2-1.9
Weight adjusted by age0.80.91.8-1.3-1.31.20.80.9-1.10.71.0-1.2-0.51.01.0-0.30.0
Bone surface4.88.513.13.63.6-3.6-2.9-3.13.2-2.7-2.42.92.7-3.1-3.1-0.8-1.9
Bone volume3.66.110.33.13.2-3.0-2.5-2.62.6-2.4-1.92.42.2-2.5-2.4-1.2-2.0
Breakpoint value in progressive ratio session0.10.11.20.1-0.1-0.1-0.1-0.40.1-0.2-0.5-0.10.40.0-0.1-0.41.1
Number of licking bursts0.00.00.4-0.10.0-0.00.10.1-0.10.10.3-0.10.10.00.1-0.60.2
Context. condit. distance diff. score0.10.10.30.00.30.20.20.1-0.20.30.2-0.3-0.50.10.20.10.5
Locomotion velocity, session 10.20.20.50.70.4-0.6-0.4-0.50.5-0.5-0.40.40.3-0.5-0.5-0.3-0.5
Locomotion distance, session 10.10.21.20.30.1-0.20.20.1-0.00.10.4-0.1-0.60.10.1-1.1-0.7
Locomotion velocity, session 20.30.42.10.70.7-0.7-0.2-0.40.3-0.2-0.60.30.7-0.4-0.3-0.21.5
Locomotion distance, session 20.30.41.0-0.1-0.20.20.70.5-0.60.70.6-0.6-0.60.60.6-1.00.8
Locomotion velocity, session 31.82.03.0-1.0-0.91.31.61.3-1.51.51.5-1.5-1.51.51.5-1.71.3
Locomotion distance, session 30.10.20.80.00.20.00.40.2-0.30.40.5-0.3-0.40.20.2-0.90.5
Stereotopy head waving bouts, day 30.70.81.6-1.2-1.31.20.91.0-0.90.80.9-0.8-0.80.90.9-0.3-0.1
Stereotopy head waving duration, day 30.91.11.7-1.2-1.31.31.01.0-1.00.91.1-1.1-0.91.11.1-0.90.0
Locomotion velocity, session 70.10.10.5-0.2-0.10.20.50.3-0.20.40.2-0.1-0.50.10.10.70.4
Locomotion distance, session 70.00.00.20.20.2-0.1-0.1-0.0-0.00.1-0.1-0.0-0.4-0.00.00.4-0.2
Stereotopy head waving bouts, day 71.61.82.1-1.3-1.21.41.41.3-1.41.41.3-1.4-1.01.41.4-1.11.4
Stereotopy head waving duration, day 72.83.44.7-2.1-1.82.01.91.9-2.02.01.8-2.0-1.11.91.9-0.92.2
Locomotion velocity, session 80.91.01.41.21.2-1.2-0.9-1.11.0-1.0-1.11.01.1-1.2-1.10.40.1
Locomotion distance, session 80.10.10.50.40.7-0.20.0-0.1-0.10.20.0-0.2-0.3-0.00.1-0.20.6
Degree of sensitization distance0.60.61.50.50.2-0.6-0.9-0.70.8-0.8-0.80.70.5-0.7-0.71.0-1.2
Degree of sensitization stereotypy2.52.85.9-1.4-1.11.51.71.6-1.81.91.6-1.7-1.31.71.8-1.32.4
Conditioned locomotion0.30.30.70.40.1-0.4-0.8-0.80.5-0.9-0.80.30.6-0.4-0.40.7-0.5
Cocaine response after cond. corrected0.40.41.2-1.0-1.10.70.70.7-0.40.60.7-0.6-0.50.40.30.3-0.5
Cocaine response after cond. not corrected0.70.81.5-1.2-1.00.91.01.0-0.81.11.0-1.0-0.50.60.60.10.7
Cocaine response before conditioning0.60.73.2-0.30.30.50.60.6-0.81.00.8-0.9-0.40.70.8-1.01.8
Saline control response0.20.30.80.50.5-0.2-0.8-0.70.3-0.6-0.90.20.50.10.10.10.7
Bone: connectivity density1.42.13.11.81.6-1.7-1.4-1.61.6-1.4-1.11.51.2-1.6-1.6-0.3-1.4
Bone: cortical apparent density3.64.78.1-2.2-1.82.32.42.5-2.32.32.5-2.1-2.82.32.3-1.10.2
Bone: cortical area1.11.78.62.02.2-1.3-0.8-0.80.8-0.5-0.00.7-0.1-0.5-0.4-2.9-0.8
Bone: cortical porosity2.83.15.92.32.4-2.0-1.9-1.91.7-1.4-1.91.52.1-1.6-1.5-0.31.2
Bone: cortical porosity1.21.33.61.71.9-1.3-1.1-1.00.9-0.6-0.90.71.1-0.7-0.6-1.40.9
Bone: cortical thickness6.610.817.7-2.2-1.73.03.53.5-3.43.54.0-3.2-4.23.63.6-3.81.2
Bone: cortical thickness4.04.78.7-1.2-0.51.82.42.3-2.32.62.6-2.1-3.02.22.4-1.91.7
Bone: cortical tissue density3.34.47.4-2.2-1.82.32.32.4-2.22.22.4-2.0-2.72.22.3-0.90.3
Condit. Reinf. active minus inactive responses0.80.92.31.41.5-0.9-1.3-1.00.8-0.8-1.10.60.8-0.6-0.4-0.50.4
Condit. Reinf. active-inactive response ratio0.30.40.90.70.9-0.5-0.9-0.70.5-0.5-0.80.30.5-0.5-0.30.10.6
Condit. Reinf. active responses1.41.74.21.82.0-1.4-1.8-1.41.2-1.2-1.30.91.2-0.9-0.7-0.7-0.1
Condit. Reinf. inactive responses0.91.12.11.41.4-1.2-1.2-0.90.9-1.0-0.70.80.7-0.8-0.7-0.9-1.2
Incentive salience index mean0.70.92.61.31.6-1.0-1.3-1.00.8-0.7-1.00.51.0-0.6-0.4-0.60.7
Condit. Reinf. lever presses0.20.21.70.10.5-0.0-0.20.0-0.20.2-0.1-0.30.40.30.4-0.61.3
Condit. Reinf. active minus inactive responses2.02.55.92.32.4-1.8-1.7-1.71.4-1.2-1.00.91.2-1.2-1.0-2.4-0.1
Condit. Reinf. active-inactive response ratio0.90.91.61.21.3-1.1-1.2-1.11.0-0.8-0.90.61.1-0.9-0.8-0.60.2
Condit. Reinf. active responses3.04.29.43.03.1-2.3-2.4-2.31.9-1.9-1.61.61.6-1.6-1.4-2.0-0.5
Condit. Reinf. inactive responses1.51.95.02.22.2-1.6-1.5-1.31.1-1.2-1.01.10.6-0.8-0.7-1.7-0.6
Condit. Reinf. lever presses0.81.04.21.72.0-1.1-1.0-0.80.6-0.5-0.60.60.6-0.3-0.2-1.50.8
Condit. Reinf. lever reinforcers received2.63.78.12.82.8-2.2-2.2-2.11.8-1.8-1.51.51.5-1.5-1.4-1.8-0.6
Conditioned reinforcement - actives0.00.00.10.10.00.0-0.3-0.30.0-0.3-0.2-0.20.20.10.0-0.30.0
Conditioned reinforcement - inactives1.21.32.91.71.5-1.5-1.0-1.31.2-1.1-1.01.10.5-1.0-1.1-0.3-0.9
Conditioned locomotion1.41.72.91.71.6-1.4-1.6-1.31.3-1.5-1.31.21.1-1.0-1.0-0.6-1.2
Patch foraging indifference point 0 sec2.54.19.22.93.0-2.3-2.4-2.11.9-1.9-1.71.71.0-1.6-1.4-1.4-1.8
Patch foraging indifference point AUC1.41.62.31.51.4-1.3-1.3-1.31.5-1.4-1.11.41.5-1.1-1.2-0.7-0.9
Delay disc. indifference point, 0s delay0.40.51.7-0.9-1.30.80.70.6-0.60.30.7-0.7-0.30.60.50.1-0.5
Delay disc. indifference point, 16s delay0.30.31.3-0.3-0.40.5-0.00.1-0.30.10.5-0.5-0.30.50.5-0.8-1.1
Delay disc. indifference point, 2s delay0.70.84.50.70.7-0.8-0.9-0.70.7-0.9-0.10.50.5-0.7-0.7-0.7-2.1
Delay disc. indifference point, 24s delay0.70.62.90.90.9-0.5-0.8-0.80.6-0.8-0.30.40.1-0.2-0.3-1.1-1.7
Delay disc. indifference point, 4s delay0.60.61.0-0.9-0.90.90.80.9-0.90.81.0-0.9-0.50.80.8-0.40.2
Delay disc. indifference point, 8s delay0.50.50.9-0.8-0.90.80.50.7-0.60.40.8-0.7-0.70.70.7-0.7-1.0
Indifference point function ln k1.21.63.8-0.7-0.21.01.11.3-1.51.51.4-1.6-1.91.21.5-0.90.8
Indifference point function log k1.21.63.8-0.7-0.21.01.11.3-1.51.51.4-1.6-1.91.21.5-0.90.8
Patch foraging total patch changes 0 sec2.74.38.72.93.0-2.4-2.5-2.22.0-2.0-1.71.81.1-1.7-1.5-1.3-1.9
Patch foraging total patch changes 12 sec5.16.69.13.02.8-2.9-2.9-2.82.9-2.9-2.62.62.5-2.4-2.3-0.5-2.1
Patch foraging total patch changes 18 sec1.72.24.02.01.7-1.7-1.7-1.61.6-1.6-1.51.51.2-1.2-1.2-1.0-0.7
Patch foraging total patch changes 24 sec2.63.16.22.52.4-1.9-1.9-1.81.7-1.8-1.21.51.1-1.2-1.2-1.9-1.9
Patch foraging total patch changes 6 sec2.23.26.42.52.5-2.1-1.9-1.81.9-1.6-1.41.81.2-1.5-1.4-1.2-1.3
Patch foraging time to switch 0 sec0.30.41.7-0.9-1.30.50.50.3-0.30.2-0.1-0.20.10.10.11.30.7
Patch foraging water rate 0 sec1.22.04.72.12.2-1.6-1.5-1.31.3-1.2-1.01.30.5-1.1-1.1-0.8-1.6
Patch foraging water rate 12 sec1.42.15.9-0.8-0.51.11.61.5-1.51.61.9-1.4-2.41.41.4-1.80.4
Patch foraging water rate 18 sec0.81.03.8-0.10.30.50.90.8-1.01.11.3-1.1-1.90.90.9-1.60.1
Patch foraging water rate 24 sec0.30.51.3-0.4-0.50.50.70.6-0.70.70.8-0.8-1.10.60.5-0.80.1
Patch foraging water rate 6 sec0.50.82.4-0.4-0.20.70.90.8-0.90.91.1-1.0-1.50.90.8-1.1-0.3
Seeking ratio, delayed vs. immediate footshock0.00.00.00.10.10.1-0.2-0.1-0.0-0.1-0.20.10.00.20.20.2-0.1
Distance traveled before self-admin0.70.81.1-1.1-1.00.91.10.9-0.80.81.0-1.0-0.30.70.7-1.00.8
Distance traveled after self-admin0.50.52.4-0.5-0.20.50.70.5-0.60.70.6-0.80.20.60.7-0.91.5
Extensor digitorum longus weight0.51.88.9-1.9-2.41.60.50.9-0.70.20.1-0.2-0.50.80.73.0-1.2
Bone: elastic displacement2.63.04.3-1.5-1.11.71.91.9-1.82.12.0-1.8-1.91.81.8-1.51.4
Bone: elastic work0.20.21.70.50.7-0.20.30.2-0.10.40.50.0-0.60.20.2-1.30.1
Bone: endosteal estimation14.331.141.46.46.2-6.4-6.1-6.26.0-5.6-5.75.65.8-5.9-5.70.9-2.2
Bone: endosteal perimeter14.530.140.96.46.0-6.3-6.0-6.26.0-5.7-5.45.55.5-5.7-5.6-0.2-2.8
Epididymis fat weight0.92.26.01.10.4-1.2-1.4-1.51.6-1.8-1.51.61.0-1.3-1.61.0-2.4
Delta time in closed arm before/after self-admin0.10.10.30.40.5-0.6-0.2-0.30.3-0.3-0.20.40.4-0.5-0.50.00.1
Delta time in open arm before/after self-admin0.60.51.9-1.1-1.41.10.50.6-0.60.30.5-0.7-0.30.80.70.2-0.3
Diff in mean of infusions in LGA sessions1.51.62.6-1.3-1.51.41.41.3-1.31.31.0-1.2-1.61.21.3-0.21.1
Delay discount exponential model param0.20.21.7-0.1-0.10.10.40.2-0.20.4-0.1-0.0-0.10.10.10.51.3
Extinction: sum of active levers before priming0.10.10.20.20.1-0.0-0.5-0.40.2-0.4-0.30.00.20.0-0.1-0.3-0.4
Active lever presses in extinction session 61.11.01.71.31.3-1.1-1.1-1.21.0-1.1-1.21.01.1-0.8-0.80.2-0.1
Bone: final force0.91.55.21.92.2-1.5-0.8-0.80.9-0.5-0.00.80.0-0.8-0.7-2.3-0.9
Bone: final moment1.01.65.42.02.3-1.6-0.8-0.91.0-0.5-0.10.90.1-0.9-0.8-2.3-0.8
Food consumed during 24 hour testing period1.41.72.41.51.0-1.3-1.4-1.41.5-1.6-1.51.61.4-1.0-1.2-0.4-1.2
Glucose0.81.21.8-1.3-1.31.11.31.3-1.11.31.1-1.2-0.91.11.00.10.9
Heart weight0.40.61.2-0.5-0.30.70.40.7-0.80.71.0-1.0-1.01.01.1-1.0-0.1
Delay discount hyperbolic model param0.20.21.8-0.00.0-0.00.30.1-0.10.3-0.20.1-0.0-0.0-0.00.51.3
Intermittent access intake day 1-15 change1.61.64.30.70.6-1.0-1.1-1.21.2-1.2-1.41.41.5-1.4-1.42.1-0.1
Intermittent access intake escalation0.80.83.30.40.3-0.6-0.8-0.80.8-0.8-1.01.01.1-1.0-1.01.80.1
Intermittent access intake escalation 23.03.04.71.31.2-1.6-1.6-1.71.8-1.7-1.82.01.9-2.0-1.92.2-0.7
Intermitt. access day 1 inactive lever presses1.71.85.32.22.3-1.6-1.4-1.51.2-1.0-1.20.80.9-0.9-0.9-1.40.2
Intermitt. access day 15 inactive lever presses1.11.22.31.31.1-1.1-1.2-1.21.1-1.0-1.51.10.7-1.1-0.90.8-0.1
Intermitt. access escalation Index2.62.33.6-1.7-1.41.51.71.8-1.51.91.6-1.7-1.41.21.5-0.71.3
Intermittent access day 1 total infusions0.30.43.60.30.3-0.00.1-0.0-0.1-0.00.3-0.3-0.70.40.3-1.9-0.6
Intermittent access day 15 total infusions0.20.20.40.50.5-0.5-0.5-0.60.5-0.6-0.60.50.1-0.4-0.50.1-0.5
Intermittent access terminal intake (last 3 days)1.92.12.71.61.4-1.6-1.5-1.61.6-1.6-1.61.61.1-1.5-1.50.4-1.2
Intermittent access total infusions1.21.32.71.61.6-1.3-1.2-1.31.1-1.2-1.01.00.5-0.9-0.9-0.8-0.9
Intermittent access day 1 locomotion1.11.22.91.61.7-1.2-1.2-1.10.9-1.0-0.90.80.4-0.6-0.6-1.2-1.0
Intermittent access day 15 total locomotion3.74.06.82.62.6-2.3-2.2-2.22.1-2.1-1.92.01.8-1.8-1.8-0.3-1.3
Intermittent access total locomotion4.45.010.83.23.3-2.6-2.5-2.32.2-2.2-2.12.11.5-1.7-1.7-0.9-1.6
Intermittent access standard deviation1.01.11.91.41.2-1.1-1.1-1.21.1-1.2-1.21.10.7-0.9-0.90.2-0.5
Left kidney weight2.15.810.5-1.2-0.81.92.32.4-2.52.72.9-2.7-3.12.62.7-3.21.4
Right kidney weight1.13.18.5-0.7-0.11.21.71.6-1.71.92.2-1.9-2.31.81.8-2.90.9
Cocaine induced anxiety0.30.30.5-0.4-0.10.50.50.6-0.60.70.7-0.6-0.60.60.6-0.10.3
Post-drug Anxiety0.50.51.3-1.1-1.00.90.70.7-0.70.50.7-0.6-0.50.70.50.6-0.2
Baseline Anxiety0.80.92.3-1.4-1.51.11.01.0-0.90.60.9-0.9-0.80.90.80.2-0.2
Tail length1.44.36.12.52.0-2.3-2.4-2.32.3-2.4-2.02.02.1-1.8-2.0-0.4-1.9
Length with tail1.76.18.52.92.7-2.9-2.6-2.72.7-2.7-2.12.42.5-2.5-2.6-1.0-1.9
Length without tail0.61.22.21.01.0-1.3-1.0-1.21.2-1.2-0.91.21.2-1.5-1.40.1-0.7
Times rat made contact with spout0.60.71.10.90.7-0.9-0.9-0.71.0-0.7-0.81.01.1-0.8-0.8-0.4-0.4
Lifetime Intake1.01.23.11.71.7-1.2-1.1-1.20.9-1.0-0.90.70.2-0.6-0.6-1.4-0.7
Liver weight, left0.61.01.41.11.0-1.1-0.9-1.21.2-1.1-0.70.81.0-1.0-1.1-0.5-0.8
Liver weight, right0.40.72.4-0.4-0.60.40.90.6-0.40.61.3-0.6-1.10.40.2-1.6-1.3
Locomotor activity0.81.36.30.91.2-0.00.30.3-0.61.00.6-0.8-1.20.91.1-2.51.8
Locomotor testing distance0.61.04.21.01.4-0.1-0.2-0.0-0.40.70.1-0.7-0.70.81.1-2.01.9
Locomotor testing rearing0.60.95.71.31.5-0.7-0.8-0.70.3-0.0-1.10.30.5-0.2-0.0-0.22.4
Locomotion in novel chamber0.00.10.2-0.1-0.0-0.10.20.2-0.10.30.3-0.3-0.20.00.0-0.50.3
Locomotion in novel chamber post-restriction2.63.14.31.91.8-2.1-1.9-1.91.9-1.8-1.41.71.4-2.0-2.0-0.2-2.0
Fecal boli incidents, locomotor time 10.10.10.4-0.5-0.50.3-0.10.1-0.0-0.0-0.1-0.20.30.10.10.6-0.3
Change in fecal boli incidents, locomotor task0.10.11.0-0.0-0.00.00.00.1-0.1-0.20.20.1-0.30.10.1-0.1-1.0
Time >=10cm from walls, locomotor time 11.51.52.9-1.2-1.01.01.71.3-1.31.51.4-1.2-1.21.00.8-0.71.4
Bouts of movement, locomotor time 10.20.21.1-0.5-0.80.50.30.4-0.30.30.2-0.1-0.60.30.31.0-0.2
Total resting periods, locomotor time 10.20.21.5-0.5-0.70.40.20.3-0.20.10.00.1-0.40.10.11.2-0.6
Rest time, locomotor task time 10.20.21.3-0.6-0.80.40.10.2-0.1-0.0-0.0-0.10.30.10.01.1-0.3
Distance moved, locomotor task time 10.30.30.60.70.6-0.6-0.5-0.80.6-0.6-0.60.70.3-0.5-0.6-0.2-0.4
Vertical activity count, locomotor time 10.20.20.50.50.6-0.5-0.3-0.50.3-0.3-0.20.4-0.1-0.4-0.4-0.7-0.2
Time >=10cm from walls, locomotor time 20.20.21.4-0.2-0.60.00.50.2-0.10.3-0.00.10.2-0.1-0.20.71.2
Bouts of movement, locomotor time 20.20.30.9-0.7-0.90.70.40.5-0.40.30.2-0.3-0.30.50.40.80.0
Total resting periods, locomotor time 20.50.51.2-0.9-1.10.90.70.7-0.70.60.5-0.6-0.50.80.70.50.2
Rest time, locomotor task time 22.93.38.8-2.7-3.02.21.91.9-1.81.51.6-1.8-1.21.61.50.70.0
Distance moved, locomotor task time 20.60.71.11.00.9-0.9-0.6-0.80.8-0.6-1.01.00.6-0.8-0.80.50.7
Vertical activity count, locomotor time 22.02.14.22.02.1-1.7-1.4-1.61.5-1.3-1.71.61.1-1.4-1.20.20.4
Light reinforcement 10.40.73.0-0.3-0.20.80.30.6-0.70.40.7-0.8-1.01.21.2-1.7-0.6
Light reinforcement 20.20.21.70.0-0.10.2-0.3-0.20.1-0.40.1-0.0-0.10.30.2-0.9-1.3
Bone: marrow area14.030.440.26.36.1-6.3-6.1-6.16.0-5.6-5.75.65.7-5.8-5.70.9-2.1
Bone: maximum diameter3.87.112.43.53.5-3.2-2.8-2.82.8-2.5-2.02.52.3-2.5-2.4-1.9-1.7
Bone: maximum force1.52.66.92.52.6-1.9-1.4-1.31.4-1.1-0.41.20.3-1.1-1.0-2.6-1.7
Bone: maximum moment1.62.87.42.52.7-2.0-1.4-1.31.5-1.1-0.51.30.4-1.2-1.1-2.5-1.7
Mean time between licks in bursts0.20.21.50.2-0.0-0.3-0.3-0.40.5-0.6-0.20.40.3-0.4-0.4-0.1-1.2
Mean num. licks in bursts0.20.20.60.50.1-0.3-0.6-0.40.6-0.6-0.70.60.3-0.3-0.40.4-0.8
Cd content in liver1.01.13.1-1.6-1.21.30.91.1-1.01.00.7-1.0-0.80.60.81.80.5
Co content in liver0.30.31.9-0.6-0.20.40.20.1-0.20.3-0.2-0.20.3-0.0-0.11.41.3
Cu content in liver0.20.20.50.20.0-0.3-0.6-0.50.4-0.7-0.70.50.6-0.4-0.40.7-0.6
Fe content in liver0.30.40.8-0.10.10.30.40.5-0.60.60.5-0.6-0.70.70.7-0.90.9
K content in liver0.80.71.40.91.0-1.1-0.8-1.00.9-0.9-0.70.61.2-0.9-0.9-0.6-0.5
Mg content in liver0.70.71.40.40.5-0.7-0.7-0.80.9-0.9-0.80.81.2-1.0-1.00.7-0.7
Mn content in liver0.20.32.70.30.8-0.30.00.10.00.20.5-0.2-0.0-0.00.1-1.6-0.3
Na content in liver0.20.21.30.10.40.10.0-0.1-0.20.20.2-0.60.20.30.4-1.11.0
Rb content in liver0.81.01.7-1.0-0.50.81.21.3-1.11.31.3-1.0-0.90.91.1-0.30.9
Se content in liver1.41.82.6-1.4-1.61.51.31.3-1.41.21.5-1.5-1.21.41.4-1.00.4
Sr content in liver0.10.10.60.40.3-0.30.0-0.30.2-0.20.10.1-0.1-0.2-0.3-0.8-0.2
Zn content in liver0.40.52.8-0.4-0.60.50.60.3-0.40.30.8-0.8-0.60.30.1-1.7-0.5
Bone: minimum diameter10.319.229.65.45.3-5.1-4.8-4.84.7-4.5-4.14.34.0-4.3-4.2-1.1-2.7
Time in familiar zone, hab. session 12.12.02.61.21.1-1.4-1.6-1.41.5-1.6-1.61.51.6-1.4-1.31.1-1.2
Time in novel zone, hab. session 12.12.03.2-1.2-1.21.51.71.5-1.51.71.5-1.4-1.81.41.3-0.81.1
Total zone transitions, hab. session 10.10.21.50.50.6-0.20.10.1-0.10.20.3-0.2-0.60.20.3-1.20.1
Total locomotion distance, hab. session 10.30.43.11.10.9-0.7-0.1-0.20.3-0.10.10.3-0.4-0.0-0.1-1.7-0.3
Locomotion velocity, hab. session 10.40.52.41.21.0-0.9-0.4-0.50.6-0.5-0.20.50.0-0.4-0.4-1.5-0.5
Time in familiar zone, hab. session 21.81.92.91.61.7-1.5-1.5-1.61.4-1.4-1.51.31.4-1.4-1.30.60.0
Time in novel zone, hab. session 21.11.12.5-1.3-1.61.01.41.2-1.01.01.3-0.8-1.20.90.7-0.5-0.5
Total zone transitions, hab. session 20.10.10.60.1-0.0-0.00.30.2-0.10.30.2-0.2-0.30.30.3-0.80.5
Total locomotion distance, hab. session 20.20.30.70.80.5-0.6-0.4-0.40.6-0.4-0.30.6-0.0-0.3-0.4-0.7-0.9
Locomotion velocity, hab. session 20.20.31.00.70.3-0.6-0.4-0.40.5-0.4-0.20.5-0.0-0.3-0.4-0.8-1.0
Novel to familiar place preference ratio0.50.51.51.11.2-0.9-0.7-0.70.7-0.6-0.50.80.4-0.7-0.7-0.2-0.7
Novelty place preference0.30.30.90.80.9-0.6-0.4-0.40.5-0.3-0.30.50.2-0.5-0.5-0.2-0.3
Time in novel zone, NPP test0.20.20.80.70.9-0.5-0.2-0.30.3-0.1-0.10.40.0-0.4-0.3-0.40.0
Total zone transitions, NPP test0.60.94.5-0.1-0.20.50.70.8-0.80.81.1-0.9-1.21.01.0-2.1-0.0
Total locomotion distance, NPP test0.30.41.11.10.7-0.8-0.4-0.40.5-0.3-0.20.5-0.2-0.4-0.4-1.0-0.8
Locomotion velocity, NPP test0.20.31.40.60.2-0.3-0.2-0.10.2-0.20.10.1-0.50.10.0-1.2-1.2
Intraocular pressure0.10.21.1-0.4-1.00.50.20.1-0.2-0.20.0-0.2-0.20.70.4-0.4-0.6
Delta distance traveled before/after self-admin0.60.61.7-0.3-0.20.70.70.7-0.90.90.7-0.7-0.70.91.0-0.81.3
Delta ambulatory time before/after self-admin0.00.10.30.20.30.0-0.10.0-0.10.10.0-0.10.00.20.3-0.60.3
Parametrial fat weight1.42.66.01.10.6-1.4-1.5-1.71.8-1.9-1.31.81.4-1.8-2.00.9-2.4
Pavlov. Cond. lever latency0.40.62.6-1.1-1.40.60.60.4-0.2-0.00.20.1-0.3-0.0-0.11.6-1.2
Pavlov. Cond. magazine entry latency1.01.32.71.51.6-1.2-1.3-1.31.0-1.0-1.00.71.2-0.7-0.8-1.10.4
Pavlov. Cond. change in total contacts0.80.82.91.41.7-0.9-1.0-0.90.5-0.5-0.80.30.7-0.3-0.3-1.11.0
Pavlov. Cond. index score0.81.02.91.51.7-1.0-1.0-1.00.7-0.6-0.70.40.8-0.4-0.4-1.60.8
Pavlov. Cond. latency score0.60.82.91.31.5-0.8-0.8-0.80.4-0.4-0.50.20.6-0.2-0.2-1.71.0
Pavlov. Cond. lever contacts0.40.41.80.91.2-0.5-0.6-0.40.2-0.1-0.40.00.6-0.00.1-0.91.3
Pavlov. Cond. magazine entry number0.50.71.7-1.1-1.30.81.01.0-0.60.70.7-0.4-0.80.40.50.9-0.5
Pavlov. Cond. intertrial magazine entries0.60.82.01.21.2-0.9-1.2-0.70.7-0.9-0.50.50.3-0.3-0.1-1.1-1.4
Pavlov. Cond. lever-magazine prob. diff.0.60.82.61.31.5-0.9-0.9-0.90.5-0.5-0.60.20.7-0.3-0.3-1.60.8
Pavlov. Cond. response bias0.60.72.21.21.5-0.8-0.9-0.90.5-0.5-0.60.20.8-0.3-0.3-1.40.8
Pavlov. Cond. lever latency0.20.21.2-0.5-0.90.30.30.10.0-0.1-0.10.1-0.1-0.1-0.31.1-0.7
Pavlov. Cond. magazine entry latency1.82.13.0-1.7-1.51.51.71.6-1.61.71.6-1.5-1.01.31.3-0.11.5
Pavlov. Cond. change in total contacts0.20.20.80.60.9-0.5-0.6-0.50.3-0.2-0.30.20.6-0.2-0.1-0.40.7
Pavlov. Cond. index score0.20.31.5-0.20.20.30.30.4-0.50.70.6-0.6-0.10.50.6-0.71.2
Pavlov. Cond. latency score0.40.52.1-0.40.00.40.50.6-0.70.90.7-0.7-0.30.60.7-0.81.5
Pavlov. Cond. lever contacts0.10.10.90.50.7-0.2-0.3-0.1-0.00.10.1-0.00.10.20.3-0.90.5
Pavlov. Cond. magazine entry number2.83.44.82.11.7-1.8-2.1-2.02.0-2.2-2.01.91.5-1.7-1.70.3-1.9
Pavlov. Cond. intertrial magazine entries12.115.822.34.33.5-4.1-4.4-4.54.4-4.7-4.24.23.8-3.8-3.90.6-3.6
Pavlov. Cond. lever-magazine prob. diff.0.30.31.3-0.30.10.30.40.5-0.60.70.7-0.6-0.20.50.6-0.71.2
Pavlov. Cond. response bias0.10.10.50.20.4-0.00.00.2-0.20.40.4-0.2-0.10.20.3-0.70.5
Time in closed arm before self-admin1.61.83.2-0.8-0.51.11.61.4-1.41.61.4-1.2-1.31.41.5-1.41.8
Time in closed arm after self-admin0.30.31.6-0.20.0-0.00.80.5-0.30.70.5-0.1-0.10.00.1-0.41.3
Time in open arm before self-admin0.20.30.6-0.8-0.70.50.50.6-0.50.60.4-0.5-0.50.20.20.50.4
Time in open arm after self-admin0.20.20.9-0.4-0.60.3-0.4-0.20.1-0.5-0.30.00.2-0.0-0.10.9-1.0
Bone: periosteal estimation7.916.428.55.35.3-4.9-4.3-4.44.3-3.9-3.64.03.5-4.0-3.8-1.4-2.0
Bone: periosteal perimeter3.45.611.73.23.4-2.8-2.4-2.62.4-2.1-1.62.11.8-2.3-2.1-2.1-1.1
Bone: post-yield work2.63.65.82.42.4-2.3-2.0-2.02.1-1.8-1.72.01.8-1.9-1.9-0.2-0.9
Progressive ratio test 1 active lever presses1.21.23.31.71.6-1.2-1.1-1.30.9-1.1-0.80.60.5-0.6-0.6-1.8-0.7
Progressive ratio test 1 breakpoint1.41.53.31.81.6-1.3-1.3-1.41.0-1.2-1.00.70.7-0.6-0.7-1.8-0.8
Progressive ratio test 1 inactive lever presses1.31.55.42.12.0-1.4-1.1-1.10.9-0.8-0.80.50.2-0.4-0.4-2.3-0.4
Progressive ratio test 2 active lever presses2.12.23.41.71.6-1.6-1.8-1.81.5-1.8-1.51.31.2-1.2-1.3-0.4-1.4
Progressive ratio test 2 breakpoint2.62.94.31.91.8-1.9-2.0-2.11.8-2.0-1.81.51.5-1.5-1.6-0.2-1.4
Progressive ratio test 2 inactive lever presses2.22.64.62.12.1-1.8-1.8-1.81.6-1.7-1.51.40.8-1.3-1.3-0.7-1.7
Incentive Sensitization - Responses2.22.33.31.31.2-1.5-1.8-1.81.7-1.8-1.61.41.5-1.5-1.60.6-1.4
Incentive Sensitization - Breakpoint2.22.23.21.31.2-1.6-1.7-1.81.7-1.7-1.61.41.5-1.5-1.60.6-1.3
Sum of active levers in priming session hrs 5-61.11.12.0-1.1-0.61.20.81.0-1.21.10.8-1.4-0.71.21.3-0.31.2
Progressive ratio0.20.21.1-0.1-0.2-0.3-0.4-0.30.4-0.4-0.20.40.6-0.5-0.60.7-1.0
Food seeking constrained by brief footshock4.65.78.72.42.1-2.6-2.4-2.62.5-2.4-2.72.43.0-2.5-2.51.6-0.3
Seeking ratio, punishment vs. effort0.91.22.21.51.4-1.2-1.1-1.11.0-1.0-1.31.01.2-0.9-0.90.10.7
Retroperitoneal fat weight1.75.57.52.72.1-2.7-2.2-2.52.7-2.5-2.32.72.0-2.4-2.60.3-2.0
Reaction time number correct1.31.83.2-1.4-1.61.41.41.5-1.41.31.8-1.5-1.31.31.3-1.1-0.3
Reaction time mean minus median0.20.22.1-0.5-0.80.20.10.20.0-0.0-0.30.10.2-0.0-0.01.5-0.2
Reaction time mean minus median AUC0.60.71.1-0.9-1.00.91.01.1-0.90.90.9-0.9-1.00.80.90.0-0.0
Reaction time num false alarms1.41.95.41.92.2-1.5-1.3-1.41.2-1.1-0.80.81.3-1.0-0.8-2.3-0.0
Reaction time num false alarms AUC1.82.55.52.22.4-1.8-1.6-1.71.5-1.4-1.11.11.6-1.3-1.1-1.9-0.4
Reaction time trials correct on left1.31.83.2-1.4-1.61.41.41.5-1.41.31.8-1.5-1.31.31.3-1.1-0.3
Reaction time trials on left1.21.73.0-1.4-1.51.41.41.4-1.31.21.7-1.4-1.31.21.2-1.0-0.4
Reaction time mean0.20.30.6-0.7-0.60.50.60.6-0.50.60.3-0.5-0.40.40.40.80.6
Reaction time mean AUC0.40.51.0-0.9-0.70.60.70.8-0.70.80.3-0.6-0.50.50.61.01.0
Median of all reaction times0.20.30.6-0.6-0.30.40.60.6-0.60.60.4-0.5-0.50.50.40.50.8
Reaction time omissions0.40.51.80.40.0-0.6-0.4-0.60.7-0.8-0.60.90.6-0.7-0.90.6-1.4
Reaction time false alarm rate2.43.46.92.42.6-2.1-2.0-2.01.8-1.7-1.81.61.9-1.7-1.5-1.10.1
Reaction time premature initiation rate0.30.41.71.11.3-0.5-0.7-0.40.4-0.3-0.40.3-0.1-0.10.1-0.8-0.3
Reaction time premature initiations0.20.31.80.30.40.2-0.00.3-0.20.30.5-0.4-0.70.50.6-1.3-0.6
Std. dev. reaction times0.20.33.0-0.2-0.3-0.2-0.1-0.10.3-0.2-0.50.40.4-0.5-0.51.7-0.3
Reaction time trials completed1.21.73.0-1.4-1.51.41.41.4-1.31.21.7-1.4-1.31.21.2-1.0-0.4
Reaction time trials AUC1.11.52.8-1.3-1.41.31.31.3-1.21.21.7-1.3-1.21.11.1-0.9-0.5
Run reversals in cocaine runway, females0.40.43.4-0.6-1.00.50.30.5-0.20.3-0.10.0-0.40.20.11.8-0.3
Run reversals in cocaine runway, males0.10.10.4-0.3-0.30.30.20.3-0.30.20.3-0.3-0.60.20.3-0.2-0.3
Latency to leave start box in cocaine runway0.50.61.2-0.8-0.70.70.90.8-0.80.90.7-0.7-0.80.60.6-0.51.1
Latency to leave start box in cocaine runway, F1.82.03.0-1.2-0.81.21.51.4-1.51.51.5-1.5-1.21.41.4-1.71.7
Latency to leave start box in cocaine runway, M0.40.42.80.1-0.0-0.4-0.4-0.40.5-0.4-0.70.70.2-0.7-0.71.7-0.2
Std. dev. time between licks in bursts0.10.10.2-0.2-0.50.1-0.0-0.20.1-0.4-0.20.20.1-0.0-0.10.5-0.4
Total sessions with >9 infusions1.61.86.5-0.4-0.41.00.90.9-1.31.01.3-1.6-1.71.71.5-2.50.1
Short access day 1 total inactive lever presses0.30.31.21.01.0-0.7-0.2-0.40.3-0.2-0.10.3-0.1-0.1-0.1-1.1-0.1
Short access day 10 total inactive lever presses0.91.01.91.41.4-1.1-1.2-0.91.1-0.8-1.11.10.8-1.0-0.80.1-0.6
Short access day 1 total infusions1.21.37.50.20.40.50.50.5-0.90.70.9-1.1-1.41.41.3-2.70.3
Short access day 10 total infusions2.83.27.12.72.4-2.1-1.8-1.91.8-1.8-1.71.70.9-1.3-1.3-1.5-1.4
Short access total infusions0.81.05.11.71.8-0.8-0.7-0.70.4-0.3-0.40.2-0.20.10.1-2.30.2
Short access day 1 locomotion0.90.94.81.51.5-0.7-0.9-0.70.4-0.7-0.30.2-0.30.10.2-2.2-1.2
Short access day 10 total locomotion6.16.812.33.53.3-2.9-3.1-2.92.7-2.8-2.82.52.3-2.1-2.1-0.4-1.6
Short access total locomotion1.51.64.82.22.0-1.3-1.4-1.21.0-1.1-1.00.90.6-0.3-0.4-1.7-0.7
One hour access (0.3 mA shock)0.50.51.01.01.0-0.9-0.8-1.00.7-0.7-0.80.60.6-0.7-0.7-0.10.0
Compulsive drug intake0.91.02.0-0.9-0.60.81.21.2-1.01.41.2-0.9-0.90.70.9-0.51.0
One hour access (shock baseline)1.01.12.01.21.0-1.1-1.2-1.41.0-1.4-1.31.00.9-0.9-1.00.2-0.7
Social response proportion0.20.20.4-0.4-0.20.50.40.7-0.50.70.6-0.6-0.30.60.6-0.30.2
Social responses0.20.31.10.40.80.00.20.3-0.40.60.4-0.4-0.50.40.6-1.01.0
Social time0.10.21.4-0.6-0.50.3-0.00.1-0.10.1-0.2-0.30.20.00.11.20.3
Soleus weight0.20.73.7-0.10.10.50.30.4-0.60.60.8-0.9-0.71.00.9-1.90.7
Bone: stiffness1.01.64.31.92.1-1.6-1.1-1.01.1-0.9-0.30.90.5-1.0-0.8-2.0-1.1
Tibialis anterior weight0.20.51.10.40.1-0.2-0.8-0.70.7-0.9-1.01.00.6-0.4-0.51.0-0.9
Time to tail flick, vehicle, before self-admin0.10.10.4-0.30.2-0.3-0.1-0.10.2-0.20.10.10.0-0.6-0.50.5-0.6
Time to tail flick, vehicle, after self-admin0.70.83.50.50.3-0.7-1.1-0.80.9-1.1-0.60.70.5-0.8-0.8-0.1-1.9
Time to tail flick, test, before self-admin0.40.44.0-0.5-0.20.0-0.10.10.2-0.1-0.40.40.7-0.5-0.42.0-0.0
Time to tail flick, test, after self-admin0.20.20.4-0.5-0.10.40.30.6-0.50.30.6-0.6-0.60.50.6-0.7-0.2
Delta time to tail flick, vehicle, before/after SA2.22.23.11.61.0-1.4-1.8-1.61.6-1.7-1.61.61.4-1.4-1.40.6-1.6
Delta time to tail flick, test, before/after SA0.20.21.60.00.30.10.10.2-0.30.20.5-0.5-0.70.30.4-1.2-0.2
Tibia length0.61.78.9-0.4-0.20.71.01.0-1.11.21.7-1.2-1.51.21.1-3.0-0.0
Ambulatory time before self-admin0.40.40.7-0.7-0.90.60.80.6-0.60.60.7-0.7-0.30.50.4-0.80.7
Ambulatory time after self-admin0.30.31.4-0.10.00.30.40.3-0.30.40.4-0.50.30.50.5-1.21.0
Bone: tissue strength1.81.83.2-1.2-1.21.11.41.5-1.31.41.6-1.3-1.31.41.3-1.80.4
Total heroin consumption0.30.33.30.20.4-0.00.1-0.0-0.10.20.1-0.40.00.20.2-1.80.9
Bone: trabecular number1.01.62.71.61.7-1.5-1.3-1.31.3-1.2-0.81.11.0-1.2-1.2-1.0-1.4
Bone: trabecular spacing0.30.41.0-0.8-0.80.70.50.4-0.60.40.1-0.5-0.10.50.41.01.0
Bone: trabecular thickness1.61.93.41.61.6-1.5-1.5-1.31.4-1.4-1.01.41.1-1.2-1.2-0.7-1.9
Bone: trabecular tissue density1.42.04.1-1.0-1.21.21.41.4-1.31.21.9-1.3-2.01.31.2-2.0-1.0
Water consumed over 24 hours0.10.21.60.40.3-0.30.00.20.20.10.10.3-0.00.10.0-1.3-0.4
Number of responses in last shaping day0.20.22.20.40.40.00.00.1-0.20.10.1-0.3-0.40.30.5-1.50.3