Smim24

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Smim24	0.03	0.03	1.7e-04	0.02	0.03	0.02	0.03	1.1e-03	4.2e-04	9.2e-04	8.6e-04
2	NAcc	gene expression	Smim24	0.03	0.02	3.5e-04	0.03	0.01	0.01	0.01	3.7e-04	3.3e-02	4.8e-02	2.1e-02
3	Eye	gene expression	Smim24	0.57	0.2	3.0e-05	0.16	0.18	0.18	0.15	1.9e-03	1.0e-03	9.1e-04	2.5e-03
4	Liver	gene expression	Smim24	0.3	0.17	6.7e-12	0.1	0.1	0.11	0.11	6.9e-11	2.2e-11	6.1e-12	5.5e-12
5	Adipose	gene expression	Smim24	0.26	0.13	0.0e+00	0.11	0.15	0.15	0.15	1.3e-12	2.0e-16	1.7e-16	3.6e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.9	3.2	6.9	0.1	0.6	1.7	-2.6	2.4
Area under the delay curve	1.7	1.9	2.7	-1.5	1.6	1.6	-0.3	1.3
BMI with tail	3.8	12.2	22.4	-4.7	4.6	3.4	1.6	1.9
BMI without tail	1.3	2.6	4.9	-2.2	2.0	1.0	1.8	0.2
Body weight	0.7	2.8	5.4	-2.3	2.1	1.7	0.8	0.8
Weight adjusted by age	0.5	0.5	2.0	-0.6	0.3	-0.3	1.4	-0.6
Bone surface	3.4	6.1	15.3	0.7	0.3	2.0	-3.9	3.2
Bone volume	3.5	6.0	15.3	0.7	0.3	2.0	-3.9	3.2
Breakpoint value in progressive ratio session	4.2	4.6	6.7	2.5	-2.6	-2.6	0.3	-1.8
Number of licking bursts	0.7	0.8	1.9	-0.2	-0.0	-0.7	1.4	-1.2
Context. condit. distance diff. score	0.2	0.2	0.4	-0.6	0.6	0.4	0.3	0.1
Locomotion velocity, session 1	0.7	0.8	2.2	0.9	-0.6	0.2	-1.5	0.8
Locomotion distance, session 1	1.0	1.3	3.4	0.3	0.1	0.9	-1.8	1.5
Locomotion velocity, session 2	2.2	2.6	5.1	2.1	-1.6	-0.4	-2.3	0.8
Locomotion distance, session 2	1.3	1.8	5.0	1.5	-0.9	0.1	-2.2	1.1
Locomotion velocity, session 3	3.9	4.5	7.7	2.8	-2.8	-2.3	-0.5	-1.4
Locomotion distance, session 3	0.0	0.0	0.1	0.1	-0.2	-0.1	0.2	-0.2
Stereotopy head waving bouts, day 3	2.5	3.0	5.9	2.4	-2.2	-1.5	-1.2	-0.5
Stereotopy head waving duration, day 3	3.1	3.7	7.0	2.7	-2.5	-1.9	-1.0	-0.8
Locomotion velocity, session 7	0.4	0.5	0.9	1.0	-0.8	-0.5	-0.7	0.0
Locomotion distance, session 7	0.2	0.3	0.8	-0.2	0.0	-0.3	0.9	-0.7
Stereotopy head waving bouts, day 7	0.8	0.9	2.0	0.0	0.2	0.9	-1.4	1.2
Stereotopy head waving duration, day 7	0.8	1.0	2.8	0.4	-0.1	0.7	-1.7	1.2
Locomotion velocity, session 8	1.2	1.5	4.3	0.7	-0.3	0.6	-2.1	1.4
Locomotion distance, session 8	0.1	0.2	0.5	0.3	-0.1	0.2	-0.7	0.4
Degree of sensitization distance	0.3	0.3	0.5	-0.6	0.7	0.5	0.1	0.3
Degree of sensitization stereotypy	2.1	2.3	3.6	-1.4	1.6	1.9	-0.8	1.7
Conditioned locomotion	1.2	1.4	3.1	-1.5	1.1	0.2	1.8	-0.7
Cocaine response after cond. corrected	2.8	3.1	6.2	-2.5	2.1	0.9	2.0	-0.2
Cocaine response after cond. not corrected	3.0	3.3	6.6	-2.6	2.2	0.9	2.1	-0.3
Cocaine response before conditioning	0.3	0.3	0.6	0.8	-0.7	-0.3	-0.6	0.1
Saline control response	0.1	0.1	0.2	-0.3	0.2	-0.1	0.5	-0.3
Bone: connectivity density	1.5	2.4	4.3	-0.4	0.9	1.7	-1.9	2.1
Bone: cortical apparent density	0.6	0.7	1.5	-1.2	1.2	0.8	0.3	0.4
Bone: cortical area	1.3	1.9	3.0	-0.8	1.2	1.6	-1.3	1.7
Bone: cortical porosity	0.3	0.4	0.7	0.8	-0.7	-0.2	-0.8	0.2
Bone: cortical porosity	0.5	0.6	1.3	0.1	0.1	0.7	-1.2	1.0
Bone: cortical thickness	1.0	1.7	2.5	-1.4	1.6	1.5	-0.4	1.3
Bone: cortical thickness	0.3	0.3	0.7	0.0	-0.2	-0.6	0.8	-0.8
Bone: cortical tissue density	0.4	0.5	1.0	-1.0	1.0	0.6	0.3	0.3
Condit. Reinf. active minus inactive responses	2.4	2.7	5.0	2.2	-2.1	-1.7	-0.6	-0.9
Condit. Reinf. active-inactive response ratio	1.8	1.9	2.8	1.6	-1.7	-1.6	0.3	-1.3
Condit. Reinf. active responses	1.9	2.3	4.7	2.2	-1.9	-1.1	-1.4	-0.1
Condit. Reinf. inactive responses	0.7	0.8	2.3	1.0	-0.6	0.0	-1.5	0.8
Incentive salience index mean	1.2	1.4	2.9	1.7	-1.4	-0.8	-1.2	0.0
Condit. Reinf. lever presses	1.2	1.7	4.0	0.2	0.3	1.2	-2.0	1.7
Condit. Reinf. active minus inactive responses	2.3	2.8	4.1	1.7	-1.9	-2.0	0.6	-1.7
Condit. Reinf. active-inactive response ratio	1.4	1.4	2.6	0.3	-0.7	-1.2	1.6	-1.6
Condit. Reinf. active responses	1.5	2.1	3.5	1.9	-1.8	-1.6	-0.2	-1.0
Condit. Reinf. inactive responses	0.7	0.8	1.8	1.3	-1.0	-0.6	-1.0	0.1
Condit. Reinf. lever presses	2.0	2.8	4.0	1.8	-2.0	-2.0	0.4	-1.6
Condit. Reinf. lever reinforcers received	1.4	1.9	2.9	1.6	-1.7	-1.6	0.1	-1.2
Conditioned reinforcement - actives	1.6	1.6	3.0	1.7	-1.6	-1.4	-0.3	-0.7
Conditioned reinforcement - inactives	0.4	0.5	0.9	-0.9	0.6	0.2	1.0	-0.5
Conditioned locomotion	5.2	6.2	10.7	3.3	-3.2	-2.7	-0.5	-1.6
Patch foraging indifference point 0 sec	0.2	0.3	0.4	-0.5	0.6	0.6	-0.4	0.5
Patch foraging indifference point AUC	0.8	0.9	1.4	1.2	-1.2	-1.2	0.1	-0.7
Delay disc. indifference point, 0s delay	7.3	8.0	12.0	-2.8	3.0	3.5	-1.4	3.0
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.4	0.5	0.4	-0.2	0.4
Delay disc. indifference point, 2s delay	4.7	5.2	7.4	-2.6	2.7	2.7	-0.6	2.2
Delay disc. indifference point, 24s delay	0.3	0.3	0.6	-0.7	0.8	0.5	0.3	0.2
Delay disc. indifference point, 4s delay	1.6	1.7	2.4	-1.0	1.3	1.5	-1.0	1.6
Delay disc. indifference point, 8s delay	0.5	0.5	1.2	-1.1	0.9	0.7	0.6	0.1
Indifference point function ln k	0.1	0.2	0.4	-0.6	0.6	0.5	0.1	0.2
Indifference point function log k	0.1	0.2	0.4	-0.6	0.6	0.5	0.1	0.2
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	-0.5	0.5	0.5	-0.2	0.3
Patch foraging total patch changes 12 sec	0.3	0.4	0.9	-0.6	0.5	-0.2	1.0	-0.5
Patch foraging total patch changes 18 sec	0.7	0.9	1.4	1.2	-1.2	-1.1	-0.0	-0.7
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	0.4	-0.2	-0.2	-0.1	0.0
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	0.5	-0.4	-0.4	-0.4	-0.3
Patch foraging time to switch 0 sec	1.9	3.0	4.6	-1.6	1.9	2.1	-1.0	1.9
Patch foraging water rate 0 sec	0.8	1.3	2.3	0.2	-0.5	-1.2	1.5	-1.5
Patch foraging water rate 12 sec	0.8	1.2	3.3	-1.2	0.8	-0.2	1.8	-0.9
Patch foraging water rate 18 sec	2.7	3.7	6.8	0.3	-0.8	-2.1	2.5	-2.6
Patch foraging water rate 24 sec	2.4	3.3	8.4	-0.7	-0.1	-1.4	2.9	-2.4
Patch foraging water rate 6 sec	1.6	2.3	4.0	0.7	-1.1	-1.7	1.6	-2.0
Seeking ratio, delayed vs. immediate footshock	2.7	3.1	6.3	2.5	-2.3	-1.5	-1.3	-0.5
Distance traveled before self-admin	0.3	0.3	0.5	-0.5	0.5	0.7	-0.4	0.6
Distance traveled after self-admin	0.6	0.6	1.2	1.1	-1.0	-0.6	-0.8	-0.2
Extensor digitorum longus weight	2.4	9.6	19.2	-4.4	3.9	2.6	2.6	0.5
Bone: elastic displacement	0.2	0.2	0.4	0.6	-0.6	-0.3	-0.3	-0.1
Bone: elastic work	0.3	0.4	0.7	-0.4	0.6	0.8	-0.5	0.8
Bone: endosteal estimation	0.3	0.8	1.1	-0.6	0.8	1.1	-0.7	1.0
Bone: endosteal perimeter	0.4	0.7	2.2	0.7	-0.4	0.3	-1.5	0.9
Epididymis fat weight	0.3	0.8	1.1	0.6	-0.8	-1.1	0.8	-1.0
Delta time in closed arm before/after self-admin	2.1	2.1	6.6	-0.8	0.2	-0.8	2.6	-1.6
Delta time in open arm before/after self-admin	1.1	1.0	1.5	-1.2	1.2	1.2	-0.4	0.8
Diff in mean of infusions in LGA sessions	1.1	1.2	1.9	1.4	-1.4	-1.2	-0.2	-0.8
Delay discount exponential model param	1.5	1.6	2.3	1.4	-1.5	-1.5	0.2	-1.1
Extinction: sum of active levers before priming	2.1	2.1	3.2	1.1	-1.4	-1.8	1.2	-1.7
Active lever presses in extinction session 6	1.8	1.8	3.4	1.9	-1.7	-1.4	-0.5	-0.7
Bone: final force	1.6	2.5	3.6	-1.3	1.7	1.9	-1.0	1.8
Bone: final moment	1.3	2.1	3.0	-1.2	1.5	1.7	-1.0	1.7
Food consumed during 24 hour testing period	0.3	0.3	0.6	-0.8	0.8	0.6	0.2	0.3
Glucose	0.7	1.0	1.9	-1.4	1.3	1.0	0.6	0.4
Heart weight	0.5	0.8	1.2	0.7	-0.9	-1.1	0.6	-1.0
Delay discount hyperbolic model param	2.2	2.3	3.3	1.7	-1.8	-1.8	0.3	-1.4
Intermittent access intake day 1-15 change	4.9	4.8	7.6	2.7	-2.8	-2.5	0.0	-1.8
Intermittent access intake escalation	6.4	6.3	9.0	2.6	-2.9	-3.0	1.0	-2.6
Intermittent access intake escalation 2	7.5	7.4	10.6	2.9	-3.2	-3.3	1.0	-2.7
Intermitt. access day 1 inactive lever presses	0.8	0.9	1.3	0.7	-0.9	-1.1	0.7	-1.1
Intermitt. access day 15 inactive lever presses	0.5	0.5	0.7	0.6	-0.7	-0.9	0.3	-0.9
Intermitt. access escalation Index	1.1	1.0	1.9	-0.4	0.8	1.1	-1.0	1.4
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.3	0.4	0.3	-0.1	0.3
Intermittent access day 15 total infusions	1.7	1.9	2.8	1.4	-1.5	-1.7	0.6	-1.4
Intermittent access terminal intake (last 3 days)	0.8	0.8	1.3	1.1	-1.0	-1.1	0.0	-0.7
Intermittent access total infusions	0.2	0.2	0.4	0.4	-0.4	-0.6	0.3	-0.6
Intermittent access day 1 locomotion	0.2	0.3	0.4	0.5	-0.5	-0.6	0.3	-0.6
Intermittent access day 15 total locomotion	2.5	2.7	4.0	2.0	-2.0	-1.9	-0.0	-1.5
Intermittent access total locomotion	0.6	0.7	1.2	1.1	-1.0	-1.0	-0.2	-0.7
Intermittent access standard deviation	2.7	2.9	4.1	1.9	-2.0	-2.0	0.6	-1.5
Left kidney weight	0.1	0.3	0.7	0.3	-0.1	0.4	-0.8	0.9
Right kidney weight	0.8	2.3	4.6	2.1	-2.0	-1.5	-0.8	-0.6
Cocaine induced anxiety	0.6	0.7	1.6	1.0	-0.7	-0.0	-1.2	0.7
Post-drug Anxiety	0.7	0.8	2.0	0.8	-0.4	0.3	-1.4	1.2
Baseline Anxiety	0.2	0.2	0.4	0.1	-0.2	-0.6	0.7	-0.7
Tail length	2.3	7.0	11.2	3.2	-3.3	-3.0	0.1	-2.2
Length with tail	1.1	4.0	7.2	2.7	-2.7	-1.8	-1.2	-1.0
Length without tail	0.4	0.9	2.7	0.3	-0.1	0.7	-1.7	1.0
Times rat made contact with spout	0.3	0.3	0.9	-0.5	0.3	-0.2	0.9	-0.6
Lifetime Intake	0.0	0.0	0.1	0.2	-0.1	-0.3	0.1	-0.2
Liver weight, left	1.3	2.1	4.3	-2.1	1.8	1.2	1.3	0.4
Liver weight, right	1.1	1.8	3.1	-1.8	1.7	1.5	0.2	1.0
Locomotor activity	1.9	2.9	5.8	2.4	-2.0	-1.0	-2.0	0.0
Locomotor testing distance	1.1	1.8	3.6	1.9	-1.6	-1.0	-1.3	-0.2
Locomotor testing rearing	0.1	0.1	0.2	0.2	-0.3	-0.5	0.2	-0.4
Locomotion in novel chamber	0.6	0.7	1.1	0.8	-0.8	-1.1	0.7	-0.9
Locomotion in novel chamber post-restriction	0.4	0.5	1.0	1.0	-0.9	-0.8	0.0	-0.5
Fecal boli incidents, locomotor time 1	1.1	1.2	2.3	-1.5	1.2	0.5	1.3	-0.2
Change in fecal boli incidents, locomotor task	0.8	0.8	2.1	0.6	-0.4	0.4	-1.5	1.0
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.2	-0.5	0.8	1.0	-0.9	1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.4	-0.4	-0.5	0.1	-0.4
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.5	-0.4	-0.4	-0.1	-0.3
Rest time, locomotor task time 1	0.1	0.1	0.2	0.4	-0.4	-0.2	-0.4	-0.0
Distance moved, locomotor task time 1	1.1	1.2	1.9	-0.6	0.8	1.2	-1.1	1.4
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.2	0.1	0.1	0.2	-0.2
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.2	-1.1	1.0	0.5	0.8	-0.1
Bouts of movement, locomotor time 2	0.5	0.5	1.6	0.7	-0.4	0.2	-1.3	0.7
Total resting periods, locomotor time 2	0.6	0.6	1.8	0.6	-0.3	0.3	-1.3	0.8
Rest time, locomotor task time 2	0.3	0.4	0.8	0.8	-0.4	-0.2	-0.9	0.3
Distance moved, locomotor task time 2	0.4	0.5	1.0	-1.0	0.8	0.3	0.9	-0.3
Vertical activity count, locomotor time 2	0.7	0.8	2.0	-0.9	0.5	-0.0	1.4	-0.9
Light reinforcement 1	3.2	5.7	11.0	3.3	-3.1	-2.3	-1.0	-1.3
Light reinforcement 2	1.0	1.3	2.4	1.5	-1.5	-1.1	-0.7	-0.6
Bone: marrow area	0.3	0.8	1.1	-0.7	0.8	1.1	-0.7	1.0
Bone: maximum diameter	0.6	1.2	3.4	1.1	-0.7	0.1	-1.8	0.9
Bone: maximum force	1.3	2.3	3.3	-1.5	1.7	1.8	-0.8	1.6
Bone: maximum moment	1.1	2.0	2.8	-1.3	1.6	1.7	-0.8	1.5
Mean time between licks in bursts	3.0	4.3	6.4	2.4	-2.5	-2.4	0.2	-1.8
Mean num. licks in bursts	0.1	0.2	0.3	-0.1	0.2	0.5	-0.5	0.6
Cd content in liver	0.2	0.2	0.3	-0.4	0.5	0.5	-0.1	0.4
Co content in liver	0.6	0.7	0.9	0.8	-0.9	-0.9	0.4	-0.9
Cu content in liver	0.7	0.8	1.5	-0.2	0.5	1.0	-1.2	1.2
Fe content in liver	0.2	0.3	0.5	0.1	-0.2	-0.5	0.7	-0.7
K content in liver	0.6	0.6	1.3	0.1	0.2	0.7	-1.1	1.0
Mg content in liver	0.8	0.8	1.9	0.1	0.2	0.8	-1.4	1.2
Mn content in liver	2.1	2.3	6.6	1.1	-0.5	0.8	-2.6	1.8
Na content in liver	1.2	1.3	2.2	-1.0	1.2	1.5	-0.6	1.2
Rb content in liver	1.1	1.4	2.5	-0.6	0.9	1.4	-1.2	1.6
Se content in liver	0.1	0.1	0.3	0.5	-0.4	-0.2	-0.4	0.0
Sr content in liver	0.8	0.7	1.7	0.0	-0.3	-0.7	1.3	-1.2
Zn content in liver	3.6	4.0	6.0	1.5	-1.9	-2.4	1.6	-2.4
Bone: minimum diameter	0.3	0.6	1.2	-0.1	0.3	0.8	-1.1	1.0
Time in familiar zone, hab. session 1	1.7	1.6	2.4	1.4	-1.5	-1.5	0.2	-1.1
Time in novel zone, hab. session 1	1.7	1.6	2.4	-0.9	1.2	1.5	-1.0	1.5
Total zone transitions, hab. session 1	0.8	1.1	2.8	1.1	-0.7	0.0	-1.7	0.8
Total locomotion distance, hab. session 1	1.6	2.3	6.8	1.2	-0.6	0.5	-2.6	1.6
Locomotion velocity, hab. session 1	1.3	1.8	4.7	1.5	-1.0	0.1	-2.2	1.1
Time in familiar zone, hab. session 2	5.3	5.5	8.0	2.6	-2.8	-2.8	0.5	-2.1
Time in novel zone, hab. session 2	4.4	4.4	6.5	-2.2	2.4	2.5	-0.8	2.1
Total zone transitions, hab. session 2	1.5	2.0	3.5	-0.4	0.9	1.5	-1.8	1.9
Total locomotion distance, hab. session 2	0.7	0.9	2.3	1.1	-0.7	0.0	-1.5	0.7
Locomotion velocity, hab. session 2	0.9	1.2	3.5	1.0	-0.6	0.2	-1.9	1.1
Novel to familiar place preference ratio	4.3	4.4	6.7	-2.0	2.2	2.6	-1.1	2.3
Novelty place preference	2.9	3.0	4.6	-1.5	1.7	2.1	-1.1	2.0
Time in novel zone, NPP test	3.0	3.1	4.8	-1.6	1.8	2.2	-1.0	1.9
Total zone transitions, NPP test	0.3	0.4	0.8	-0.1	0.4	0.7	-0.9	0.9
Total locomotion distance, NPP test	0.7	1.0	1.8	-0.1	0.5	1.0	-1.3	1.3
Locomotion velocity, NPP test	0.5	0.7	1.8	0.2	0.2	0.7	-1.3	1.1
Intraocular pressure	1.0	1.4	2.8	0.1	-0.5	-1.3	1.7	-1.5
Delta distance traveled before/after self-admin	0.9	1.0	1.8	1.3	-1.3	-1.0	-0.6	-0.5
Delta ambulatory time before/after self-admin	0.9	1.0	2.1	1.4	-1.2	-0.9	-0.8	-0.2
Parametrial fat weight	0.4	0.7	1.1	0.9	-1.1	-1.0	0.1	-0.8
Pavlov. Cond. lever latency	0.7	0.8	1.8	0.0	-0.3	-0.9	1.3	-1.3
Pavlov. Cond. magazine entry latency	1.9	2.4	3.7	1.9	-1.9	-1.8	-0.1	-1.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.1	-0.0
Pavlov. Cond. index score	0.3	0.4	0.9	0.7	-0.5	-0.1	-1.0	0.4
Pavlov. Cond. latency score	0.5	0.6	1.8	0.7	-0.4	0.2	-1.3	0.8
Pavlov. Cond. lever contacts	0.9	1.1	2.6	0.2	0.1	0.8	-1.6	1.4
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	-0.9	0.8	0.8	0.2	0.4
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.2	0.3	-0.4	-1.0	0.9	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.9	1.0	-0.8	-0.3	-1.0	0.2
Pavlov. Cond. response bias	0.6	0.7	1.3	1.2	-1.1	-0.9	-0.4	-0.4
Pavlov. Cond. lever latency	0.5	0.7	1.3	-1.2	1.1	0.8	0.4	0.3
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	0.8	-0.8	-0.4	-0.6	0.0
Pavlov. Cond. change in total contacts	0.6	0.8	1.5	1.2	-1.2	-0.9	-0.1	-0.6
Pavlov. Cond. index score	0.6	0.8	1.5	1.2	-1.2	-0.9	-0.3	-0.5
Pavlov. Cond. latency score	0.5	0.6	1.3	1.1	-1.1	-0.7	-0.6	-0.2
Pavlov. Cond. lever contacts	0.6	0.8	1.4	1.1	-1.2	-1.0	0.0	-0.7
Pavlov. Cond. magazine entry number	0.5	0.6	1.2	-1.1	1.0	0.5	0.7	0.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	-0.8	0.7	-0.0	1.0	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.4	1.2	-1.2	-0.8	-0.5	-0.3
Pavlov. Cond. response bias	1.4	1.9	3.2	1.7	-1.8	-1.5	-0.0	-1.1
Time in closed arm before self-admin	1.7	1.9	2.6	-1.0	1.3	1.6	-1.4	1.6
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	-0.2	-0.2	0.2	-0.2
Time in open arm before self-admin	1.0	1.0	1.5	1.2	-1.2	-1.2	0.2	-0.9
Time in open arm after self-admin	0.4	0.4	0.9	-0.9	0.8	0.6	0.3	0.1
Bone: periosteal estimation	1.0	2.0	3.3	-0.8	1.2	1.7	-1.5	1.8
Bone: periosteal perimeter	0.7	1.1	2.9	0.3	0.1	0.8	-1.7	1.3
Bone: post-yield work	0.4	0.5	1.0	-1.0	1.0	0.7	0.2	0.4
Progressive ratio test 1 active lever presses	0.1	0.2	0.4	-0.4	0.3	-0.0	0.6	-0.3
Progressive ratio test 1 breakpoint	0.1	0.2	0.3	-0.5	0.5	0.1	0.5	-0.1
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.1	-0.0
Progressive ratio test 2 active lever presses	0.4	0.4	0.8	0.5	-0.6	-0.9	0.5	-0.8
Progressive ratio test 2 breakpoint	0.2	0.3	0.5	0.6	-0.6	-0.7	0.1	-0.4
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.2	0.0
Incentive Sensitization - Responses	0.6	0.6	1.0	0.6	-0.7	-1.0	0.5	-0.8
Incentive Sensitization - Breakpoint	0.5	0.5	0.9	0.7	-0.8	-1.0	0.4	-0.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.0	-0.0	-0.1	0.4	-0.2
Progressive ratio	0.2	0.2	0.8	-0.4	0.2	-0.1	0.9	-0.3
Food seeking constrained by brief footshock	0.0	0.1	0.1	0.4	-0.2	-0.3	0.1	-0.1
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	0.3	-0.1	-0.0	-0.6	0.2
Retroperitoneal fat weight	0.2	0.8	1.7	-1.3	1.1	0.6	0.8	-0.1
Reaction time number correct	0.6	0.8	2.4	-0.9	0.6	-0.3	1.5	-0.8
Reaction time mean minus median	0.5	0.7	1.2	1.1	-1.0	-0.9	-0.4	-0.3
Reaction time mean minus median AUC	0.8	1.0	2.3	0.2	0.2	0.8	-1.5	1.4
Reaction time num false alarms	0.1	0.1	0.4	-0.2	0.1	-0.2	0.7	-0.4
Reaction time num false alarms AUC	0.3	0.4	1.2	-0.3	0.1	-0.4	1.1	-0.7
Reaction time trials correct on left	0.6	0.8	2.4	-0.9	0.6	-0.3	1.5	-0.8
Reaction time trials on left	0.5	0.8	2.1	-0.9	0.6	-0.2	1.4	-0.7
Reaction time mean	0.5	0.7	1.6	0.0	0.3	0.7	-1.3	1.1
Reaction time mean AUC	0.5	0.7	1.5	-0.1	0.4	0.8	-1.2	1.1
Median of all reaction times	0.8	1.1	1.8	-0.6	0.8	1.1	-1.2	1.3
Reaction time omissions	0.1	0.2	0.4	0.6	-0.5	-0.3	-0.5	0.0
Reaction time false alarm rate	0.0	0.0	0.0	-0.0	0.1	0.1	0.0	0.1
Reaction time premature initiation rate	1.1	1.5	2.3	1.1	-1.3	-1.5	0.6	-1.5
Reaction time premature initiations	1.5	2.2	4.1	0.7	-1.1	-1.7	1.4	-2.0
Std. dev. reaction times	0.2	0.3	0.6	0.6	-0.4	-0.2	-0.8	0.4
Reaction time trials completed	0.5	0.8	2.1	-0.9	0.6	-0.2	1.4	-0.7
Reaction time trials AUC	0.7	1.0	2.8	-0.8	0.5	-0.4	1.7	-1.0
Run reversals in cocaine runway, females	0.5	0.5	1.1	0.9	-0.6	-0.2	-1.1	0.4
Run reversals in cocaine runway, males	0.6	0.6	1.4	1.2	-0.9	-0.5	-0.7	0.1
Latency to leave start box in cocaine runway	0.8	0.9	2.4	1.1	-0.6	-0.0	-1.6	0.7
Latency to leave start box in cocaine runway, F	1.6	1.7	3.8	0.1	0.5	1.1	-2.0	1.8
Latency to leave start box in cocaine runway, M	3.3	3.1	4.6	1.7	-2.0	-2.1	0.8	-1.9
Std. dev. time between licks in bursts	0.6	0.7	1.8	1.0	-0.7	-0.1	-1.3	0.5
Total sessions with >9 infusions	0.2	0.2	0.6	0.1	0.2	0.3	-0.6	0.8
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.2	-0.2	-0.2	0.3	-0.2
Short access day 10 total inactive lever presses	0.3	0.4	0.7	0.2	-0.4	-0.6	0.7	-0.8
Short access day 1 total infusions	0.3	0.3	0.7	0.3	0.0	0.2	-0.8	0.7
Short access day 10 total infusions	0.0	0.0	0.1	0.1	0.1	-0.3	0.3	-0.2
Short access total infusions	0.1	0.1	0.2	0.0	0.2	0.1	-0.3	0.5
Short access day 1 locomotion	0.4	0.5	1.0	0.9	-0.7	-0.3	-1.0	0.0
Short access day 10 total locomotion	3.2	3.6	5.3	2.2	-2.3	-2.2	0.1	-1.7
Short access total locomotion	0.5	0.5	1.0	1.0	-0.8	-0.8	-0.5	-0.3
One hour access (0.3 mA shock)	0.1	0.2	0.3	-0.5	0.5	0.3	0.3	0.1
Compulsive drug intake	0.8	0.8	1.5	-1.0	0.9	1.2	-0.3	0.9
One hour access (shock baseline)	0.3	0.3	0.6	0.1	-0.2	-0.6	0.8	-0.7
Social response proportion	0.3	0.4	0.7	0.8	-0.7	-0.3	-0.7	0.1
Social responses	4.1	5.2	10.7	3.3	-3.0	-1.9	-1.7	-0.4
Social time	0.4	0.5	1.0	-1.0	0.9	0.6	0.5	0.2
Soleus weight	5.4	15.9	28.4	-5.3	5.1	4.2	1.3	2.3
Bone: stiffness	2.5	3.9	6.0	-2.2	2.4	2.3	-0.3	1.7
Tibialis anterior weight	0.6	2.1	3.5	-1.9	1.8	1.7	0.4	0.9
Time to tail flick, vehicle, before self-admin	0.7	0.8	1.9	0.9	-0.5	0.1	-1.4	0.9
Time to tail flick, vehicle, after self-admin	0.6	0.7	1.1	0.3	-0.5	-0.9	1.0	-1.1
Time to tail flick, test, before self-admin	0.7	0.7	1.7	0.4	-0.0	0.4	-1.3	1.1
Time to tail flick, test, after self-admin	0.3	0.3	1.0	0.5	-0.2	0.0	-1.0	0.6
Delta time to tail flick, vehicle, before/after SA	1.0	0.9	2.6	-0.7	0.3	-0.4	1.6	-1.1
Delta time to tail flick, test, before/after SA	0.5	0.4	0.9	0.2	-0.4	-0.7	0.7	-1.0
Tibia length	0.6	1.8	3.1	1.6	-1.8	-1.5	-0.1	-1.1
Ambulatory time before self-admin	0.2	0.2	0.3	-0.4	0.5	0.5	-0.3	0.4
Ambulatory time after self-admin	0.3	0.4	0.6	0.8	-0.8	-0.4	-0.6	-0.2
Bone: tissue strength	1.3	1.3	2.2	-1.4	1.5	1.3	-0.1	0.9
Total heroin consumption	1.1	1.3	2.6	1.6	-1.4	-1.2	-0.4	-0.5
Bone: trabecular number	0.9	1.4	4.0	1.1	-0.7	0.4	-2.0	1.2
Bone: trabecular spacing	2.0	2.5	7.1	-0.7	0.1	-1.1	2.7	-2.0
Bone: trabecular thickness	4.4	5.3	11.8	0.2	0.7	2.2	-3.4	3.1
Bone: trabecular tissue density	1.2	1.8	3.5	-1.9	1.6	0.6	1.5	-0.3
Water consumed over 24 hours	1.0	1.2	1.9	-0.7	1.0	1.3	-1.0	1.4
Number of responses in last shaping day	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.1	-0.1