Hub : Genes

Slc6a4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Slc6a4 0.03 0.02 4.8e-04 0.02 0.02 0.02 0.02 5.4e-03 5.9e-03 1.8e-03 5.3e-03
2 Liver gene expression Slc6a4 0.03 0.03 5.7e-04 0.01 0.02 0.01 0.01 1.0e-02 6.4e-03 1.1e-02 2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.93.53.7-1.81.9
Area under the delay curve1.72.72.71.6-1.6
BMI with tail1.65.45.8-2.42.2
BMI without tail1.37.17.6-2.82.6
Body weight2.812.512.8-3.63.5
Weight adjusted by age0.10.30.4-0.60.3
Bone surface1.22.32.5-1.51.6
Bone volume1.22.32.4-1.61.5
Breakpoint value in progressive ratio session0.71.21.7-0.81.3
Number of licking bursts0.10.30.50.7-0.5
Context. condit. distance diff. score0.60.70.7-0.80.9
Locomotion velocity, session 11.41.62.5-0.81.6
Locomotion distance, session 10.20.20.30.40.5
Locomotion velocity, session 20.00.00.10.10.3
Locomotion distance, session 20.60.91.5-0.61.2
Locomotion velocity, session 32.52.93.01.7-1.7
Locomotion distance, session 30.40.40.50.6-0.7
Stereotopy head waving bouts, day 30.00.00.10.10.2
Stereotopy head waving duration, day 30.30.40.50.7-0.6
Locomotion velocity, session 70.70.81.1-1.10.6
Locomotion distance, session 70.50.60.7-0.80.8
Stereotopy head waving bouts, day 70.70.80.9-0.90.8
Stereotopy head waving duration, day 70.30.40.4-0.60.6
Locomotion velocity, session 80.00.00.00.00.1
Locomotion distance, session 80.50.71.2-0.51.1
Degree of sensitization distance3.23.43.5-1.91.8
Degree of sensitization stereotypy0.80.91.0-1.00.9
Conditioned locomotion1.01.11.21.1-1.1
Cocaine response after cond. corrected1.42.22.2-1.51.5
Cocaine response after cond. not corrected1.92.83.0-1.61.7
Cocaine response before conditioning0.10.20.3-0.30.5
Saline control response0.00.00.10.3-0.2
Bone: connectivity density3.65.75.9-2.32.4
Bone: cortical apparent density0.10.20.40.3-0.6
Bone: cortical area1.11.82.51.0-1.6
Bone: cortical porosity0.30.30.4-0.70.5
Bone: cortical porosity0.10.10.2-0.40.3
Bone: cortical thickness1.83.04.11.4-2.0
Bone: cortical thickness0.00.00.0-0.1-0.2
Bone: cortical tissue density0.10.10.20.1-0.4
Condit. Reinf. active minus inactive responses0.30.40.40.6-0.6
Condit. Reinf. active-inactive response ratio0.00.00.10.0-0.3
Condit. Reinf. active responses0.00.00.00.00.1
Condit. Reinf. inactive responses0.20.20.3-0.40.6
Incentive salience index mean0.00.10.10.0-0.3
Condit. Reinf. lever presses0.60.91.5-1.20.5
Condit. Reinf. active minus inactive responses0.30.50.90.9-0.4
Condit. Reinf. active-inactive response ratio0.50.81.31.1-0.6
Condit. Reinf. active responses0.10.20.20.5-0.3
Condit. Reinf. inactive responses0.20.20.4-0.60.2
Condit. Reinf. lever presses2.53.74.12.0-1.8
Condit. Reinf. lever reinforcers received0.40.50.60.8-0.6
Conditioned reinforcement - actives0.00.20.2-0.40.5
Conditioned reinforcement - inactives0.00.00.00.20.1
Conditioned locomotion0.00.00.0-0.10.2
Patch foraging indifference point 0 sec0.10.40.40.6-0.6
Patch foraging indifference point AUC1.22.93.21.8-1.7
Delay disc. indifference point, 0s delay1.11.21.31.2-1.0
Delay disc. indifference point, 16s delay1.62.32.41.6-1.5
Delay disc. indifference point, 2s delay2.83.13.51.9-1.7
Delay disc. indifference point, 24s delay0.30.60.7-0.80.6
Delay disc. indifference point, 4s delay0.40.40.60.7-0.4
Delay disc. indifference point, 8s delay0.50.91.30.8-1.1
Indifference point function ln k0.31.01.0-1.01.0
Indifference point function log k0.31.01.0-1.01.0
Patch foraging total patch changes 0 sec0.10.30.30.5-0.5
Patch foraging total patch changes 12 sec0.20.30.30.5-0.6
Patch foraging total patch changes 18 sec0.82.02.21.5-1.3
Patch foraging total patch changes 24 sec0.82.93.41.8-1.6
Patch foraging total patch changes 6 sec3.15.25.42.3-2.2
Patch foraging time to switch 0 sec0.52.12.1-1.51.4
Patch foraging water rate 0 sec0.93.43.61.9-1.8
Patch foraging water rate 12 sec0.10.40.6-0.80.4
Patch foraging water rate 18 sec0.30.60.8-0.90.6
Patch foraging water rate 24 sec0.30.40.50.6-0.7
Patch foraging water rate 6 sec0.91.41.61.1-1.3
Seeking ratio, delayed vs. immediate footshock1.72.52.91.4-1.7
Distance traveled before self-admin2.14.64.72.1-2.2
Distance traveled after self-admin0.00.10.10.3-0.3
Extensor digitorum longus weight0.83.43.9-2.01.7
Bone: elastic displacement2.32.93.11.7-1.8
Bone: elastic work6.68.79.62.8-3.1
Bone: endosteal estimation0.20.40.60.8-0.4
Bone: endosteal perimeter0.00.10.10.3-0.2
Epididymis fat weight5.327.027.9-5.35.1
Delta time in closed arm before/after self-admin2.22.12.41.3-1.5
Delta time in open arm before/after self-admin4.04.74.8-2.12.2
Diff in mean of infusions in LGA sessions0.40.60.9-0.60.9
Delay discount exponential model param1.31.71.8-1.31.3
Extinction: sum of active levers before priming0.50.81.3-0.51.1
Active lever presses in extinction session 60.50.50.7-0.50.9
Bone: final force0.20.40.50.4-0.7
Bone: final moment0.30.50.70.5-0.8
Food consumed during 24 hour testing period0.00.00.10.0-0.3
Glucose1.52.32.61.4-1.6
Heart weight1.82.83.2-1.61.8
Delay discount hyperbolic model param1.72.22.4-1.51.5
Intermittent access intake day 1-15 change0.00.00.00.2-0.1
Intermittent access intake escalation0.00.00.00.10.0
Intermittent access intake escalation 20.30.50.50.7-0.7
Intermitt. access day 1 inactive lever presses0.00.60.70.8-0.7
Intermitt. access day 15 inactive lever presses0.31.41.71.3-1.1
Intermitt. access escalation Index0.41.31.4-1.11.2
Intermittent access day 1 total infusions0.00.00.00.10.2
Intermittent access day 15 total infusions0.10.20.4-0.30.6
Intermittent access terminal intake (last 3 days)0.20.40.6-0.40.7
Intermittent access total infusions0.00.00.00.10.2
Intermittent access day 1 locomotion0.00.10.10.3-0.1
Intermittent access day 15 total locomotion0.00.10.1-0.30.4
Intermittent access total locomotion0.10.10.2-0.30.4
Intermittent access standard deviation0.10.40.60.7-0.4
Left kidney weight0.00.30.3-0.50.5
Right kidney weight0.10.91.1-1.10.8
Cocaine induced anxiety0.20.50.80.9-0.4
Post-drug Anxiety0.40.50.5-0.60.7
Baseline Anxiety0.91.52.2-1.50.9
Tail length0.63.03.2-1.81.7
Length with tail0.83.63.8-1.91.9
Length without tail0.21.21.2-1.11.1
Times rat made contact with spout0.10.10.2-0.40.1
Lifetime Intake0.00.10.1-0.10.3
Liver weight, left5.18.99.1-3.02.9
Liver weight, right5.18.89.3-3.12.9
Locomotor activity0.20.30.60.7-0.2
Locomotor testing distance0.10.30.50.7-0.4
Locomotor testing rearing0.00.10.20.4-0.2
Locomotion in novel chamber2.53.44.11.6-2.0
Locomotion in novel chamber post-restriction0.10.30.6-0.80.1
Fecal boli incidents, locomotor time 11.02.63.1-1.81.4
Change in fecal boli incidents, locomotor task0.40.40.50.7-0.5
Time >=10cm from walls, locomotor time 10.00.00.1-0.20.1
Bouts of movement, locomotor time 10.40.50.50.7-0.7
Total resting periods, locomotor time 10.10.10.10.4-0.4
Rest time, locomotor task time 10.10.10.2-0.30.4
Distance moved, locomotor task time 10.30.81.01.0-0.7
Vertical activity count, locomotor time 10.00.20.20.5-0.4
Time >=10cm from walls, locomotor time 20.20.60.6-0.80.7
Bouts of movement, locomotor time 20.10.50.70.8-0.5
Total resting periods, locomotor time 20.00.10.20.4-0.2
Rest time, locomotor task time 20.10.10.1-0.30.3
Distance moved, locomotor task time 20.50.70.70.8-0.8
Vertical activity count, locomotor time 20.41.01.10.9-1.0
Light reinforcement 10.00.00.00.0-0.2
Light reinforcement 20.30.60.70.8-0.7
Bone: marrow area0.20.40.60.8-0.5
Bone: maximum diameter0.40.81.20.7-1.1
Bone: maximum force0.50.91.20.8-1.1
Bone: maximum moment0.61.21.51.0-1.2
Mean time between licks in bursts0.21.21.3-1.11.1
Mean num. licks in bursts0.30.81.1-1.10.7
Cd content in liver1.01.11.51.2-0.9
Co content in liver0.20.30.40.6-0.4
Cu content in liver1.41.71.81.3-1.3
Fe content in liver1.51.92.1-1.31.5
K content in liver0.20.20.2-0.40.4
Mg content in liver0.40.40.40.6-0.6
Mn content in liver0.20.20.30.5-0.5
Na content in liver0.00.00.0-0.0-0.1
Rb content in liver0.00.00.00.00.2
Se content in liver1.31.62.51.6-0.8
Sr content in liver0.40.30.4-0.70.5
Zn content in liver0.30.30.5-0.40.7
Bone: minimum diameter0.10.20.20.4-0.5
Time in familiar zone, hab. session 10.30.30.40.4-0.7
Time in novel zone, hab. session 10.10.10.20.10.4
Total zone transitions, hab. session 10.20.30.50.7-0.3
Total locomotion distance, hab. session 10.00.10.10.3-0.1
Locomotion velocity, hab. session 10.20.30.30.6-0.5
Time in familiar zone, hab. session 20.00.00.10.0-0.3
Time in novel zone, hab. session 20.40.40.60.8-0.5
Total zone transitions, hab. session 20.20.20.4-0.20.6
Total locomotion distance, hab. session 20.00.10.10.30.1
Locomotion velocity, hab. session 20.10.10.20.40.0
Novel to familiar place preference ratio0.30.40.4-0.60.6
Novelty place preference0.50.60.6-0.80.8
Time in novel zone, NPP test0.60.70.8-0.90.9
Total zone transitions, NPP test0.10.20.30.50.1
Total locomotion distance, NPP test1.11.52.31.5-0.8
Locomotion velocity, NPP test1.31.82.71.6-1.0
Intraocular pressure0.91.51.71.1-1.3
Delta distance traveled before/after self-admin2.83.03.4-1.61.8
Delta ambulatory time before/after self-admin1.52.52.6-1.61.6
Parametrial fat weight7.517.617.8-4.24.2
Pavlov. Cond. lever latency0.00.00.00.20.1
Pavlov. Cond. magazine entry latency0.10.10.1-0.30.3
Pavlov. Cond. change in total contacts0.20.20.40.3-0.6
Pavlov. Cond. index score0.00.00.0-0.2-0.0
Pavlov. Cond. latency score0.10.10.1-0.40.1
Pavlov. Cond. lever contacts0.00.00.1-0.3-0.1
Pavlov. Cond. magazine entry number0.00.00.1-0.10.2
Pavlov. Cond. intertrial magazine entries0.20.30.40.6-0.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.0-0.1
Pavlov. Cond. response bias0.00.00.0-0.20.0
Pavlov. Cond. lever latency3.14.34.8-2.22.0
Pavlov. Cond. magazine entry latency0.10.10.10.3-0.4
Pavlov. Cond. change in total contacts1.12.72.91.7-1.6
Pavlov. Cond. index score2.13.33.61.9-1.7
Pavlov. Cond. latency score2.33.84.02.0-1.9
Pavlov. Cond. lever contacts1.62.32.71.6-1.4
Pavlov. Cond. magazine entry number0.10.10.1-0.40.2
Pavlov. Cond. intertrial magazine entries0.30.60.6-0.70.8
Pavlov. Cond. lever-magazine prob. diff.1.72.62.91.7-1.5
Pavlov. Cond. response bias1.52.02.31.5-1.3
Time in closed arm before self-admin0.81.41.5-1.21.2
Time in closed arm after self-admin0.91.01.40.8-1.2
Time in open arm before self-admin1.41.81.91.4-1.3
Time in open arm after self-admin0.60.70.7-0.80.9
Bone: periosteal estimation0.51.31.41.1-1.2
Bone: periosteal perimeter0.40.70.90.7-1.0
Bone: post-yield work0.30.60.8-0.90.5
Progressive ratio test 1 active lever presses0.61.01.21.1-0.9
Progressive ratio test 1 breakpoint0.71.21.41.2-1.0
Progressive ratio test 1 inactive lever presses1.64.14.32.1-2.0
Progressive ratio test 2 active lever presses0.60.81.11.0-0.8
Progressive ratio test 2 breakpoint0.60.81.01.0-0.7
Progressive ratio test 2 inactive lever presses0.20.60.70.8-0.7
Incentive Sensitization - Responses0.00.00.00.00.0
Incentive Sensitization - Breakpoint0.00.00.0-0.00.1
Sum of active levers in priming session hrs 5-61.91.82.2-1.11.5
Progressive ratio0.00.10.1-0.30.2
Food seeking constrained by brief footshock0.10.10.1-0.20.4
Seeking ratio, punishment vs. effort0.10.20.30.5-0.4
Retroperitoneal fat weight0.52.12.2-1.51.4
Reaction time number correct0.20.70.9-0.80.9
Reaction time mean minus median0.10.30.4-0.50.6
Reaction time mean minus median AUC0.32.22.2-1.51.4
Reaction time num false alarms4.57.67.82.8-2.7
Reaction time num false alarms AUC3.37.77.72.8-2.8
Reaction time trials correct on left0.20.70.9-0.80.9
Reaction time trials on left0.20.80.9-0.80.9
Reaction time mean0.41.01.1-0.91.1
Reaction time mean AUC0.30.60.8-0.70.9
Median of all reaction times0.40.60.8-0.60.9
Reaction time omissions1.11.81.9-1.41.3
Reaction time false alarm rate5.47.47.52.7-2.7
Reaction time premature initiation rate0.00.00.1-0.10.3
Reaction time premature initiations0.10.20.3-0.30.5
Std. dev. reaction times0.31.01.0-1.01.0
Reaction time trials completed0.20.80.9-0.80.9
Reaction time trials AUC0.20.60.7-0.70.8
Run reversals in cocaine runway, females0.00.00.1-0.10.2
Run reversals in cocaine runway, males0.10.10.2-0.40.2
Latency to leave start box in cocaine runway0.00.00.0-0.1-0.1
Latency to leave start box in cocaine runway, F0.10.10.2-0.40.3
Latency to leave start box in cocaine runway, M0.00.00.00.1-0.2
Std. dev. time between licks in bursts0.00.00.0-0.20.0
Total sessions with >9 infusions0.00.10.1-0.20.2
Short access day 1 total inactive lever presses1.32.62.7-1.71.6
Short access day 10 total inactive lever presses0.00.20.30.5-0.4
Short access day 1 total infusions0.00.00.1-0.10.2
Short access day 10 total infusions0.00.10.1-0.20.3
Short access total infusions0.00.00.00.2-0.2
Short access day 1 locomotion0.20.30.40.6-0.5
Short access day 10 total locomotion0.51.82.61.6-1.0
Short access total locomotion1.11.62.01.4-1.1
One hour access (0.3 mA shock)0.10.10.10.4-0.3
Compulsive drug intake1.21.82.1-1.51.2
One hour access (shock baseline)0.20.60.70.8-0.7
Social response proportion2.73.43.9-2.01.7
Social responses1.82.42.5-1.61.5
Social time1.52.42.7-1.61.5
Soleus weight2.88.28.2-2.92.8
Bone: stiffness1.01.82.2-1.21.5
Tibialis anterior weight2.910.110.3-3.23.1
Time to tail flick, vehicle, before self-admin0.00.00.0-0.00.1
Time to tail flick, vehicle, after self-admin0.20.50.60.8-0.6
Time to tail flick, test, before self-admin0.00.10.1-0.30.1
Time to tail flick, test, after self-admin0.00.00.10.1-0.2
Delta time to tail flick, vehicle, before/after SA0.10.10.10.3-0.3
Delta time to tail flick, test, before/after SA0.40.50.60.8-0.7
Tibia length0.00.00.0-0.1-0.0
Ambulatory time before self-admin1.02.93.01.7-1.7
Ambulatory time after self-admin0.00.00.00.10.1
Bone: tissue strength1.11.21.50.9-1.2
Total heroin consumption5.16.06.7-2.32.6
Bone: trabecular number2.44.65.0-2.02.2
Bone: trabecular spacing0.20.20.40.3-0.6
Bone: trabecular thickness0.00.10.10.3-0.1
Bone: trabecular tissue density1.42.42.71.6-1.5
Water consumed over 24 hours0.00.00.00.10.0
Number of responses in last shaping day1.01.21.21.1-1.1