Hub : Genes

Slc46a1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Slc46a1	0.03	0.03	1.1e-03	0.01	0.02	0	0.01	3.6e-02	1.9e-03	2.2e-01	4.7e-02
2	NAcc	gene expression	Slc46a1	0.02	0.01	2.5e-03	0.02	0.01	0.01	0.01	1.0e-03	3.0e-03	2.8e-03	2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	2.3	3.9	4.0	1.9	-2.0
Area under the delay curve	2.0	2.3	3.2	-1.2	1.8
BMI with tail	1.7	5.9	6.7	2.6	-2.3
BMI without tail	1.9	5.8	6.2	2.5	-2.3
Body weight	2.3	10.2	12.5	3.5	-2.8
Weight adjusted by age	0.2	0.3	0.5	0.3	-0.7
Bone surface	1.7	3.0	3.0	1.7	-1.7
Bone volume	1.4	2.5	2.6	1.6	-1.6
Breakpoint value in progressive ratio session	0.5	0.6	0.8	0.6	-0.9
Number of licking bursts	0.2	0.4	0.5	-0.7	0.6
Context. condit. distance diff. score	0.6	0.8	0.8	0.8	-0.9
Locomotion velocity, session 1	2.0	2.2	2.6	1.6	-1.4
Locomotion distance, session 1	0.1	0.2	0.3	0.6	-0.2
Locomotion velocity, session 2	0.0	0.0	0.0	0.2	-0.2
Locomotion distance, session 2	1.2	1.6	1.7	1.3	-1.3
Locomotion velocity, session 3	3.1	3.5	4.0	-2.0	1.7
Locomotion distance, session 3	0.5	0.5	0.6	-0.6	0.8
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	0.1	-0.3
Stereotopy head waving duration, day 3	0.4	0.5	0.8	-0.9	0.4
Locomotion velocity, session 7	0.3	0.3	0.4	0.4	-0.7
Locomotion distance, session 7	0.4	0.5	0.5	0.7	-0.7
Stereotopy head waving bouts, day 7	0.7	0.7	0.9	0.8	-1.0
Stereotopy head waving duration, day 7	0.3	0.4	0.5	0.4	-0.7
Locomotion velocity, session 8	0.0	0.0	0.1	0.2	-0.0
Locomotion distance, session 8	0.8	1.2	1.2	1.1	-1.1
Degree of sensitization distance	3.2	3.2	3.4	1.8	-1.8
Degree of sensitization stereotypy	0.7	0.8	0.9	0.8	-1.0
Conditioned locomotion	1.5	1.7	2.1	-1.5	1.1
Cocaine response after cond. corrected	1.8	2.1	2.2	1.4	-1.5
Cocaine response after cond. not corrected	2.3	2.8	2.8	1.6	-1.7
Cocaine response before conditioning	0.2	0.2	0.2	0.5	-0.4
Saline control response	0.0	0.0	0.0	-0.1	-0.2
Bone: connectivity density	4.2	6.5	7.1	2.4	-2.7
Bone: cortical apparent density	0.5	0.6	0.8	-0.9	0.7
Bone: cortical area	1.7	2.6	3.1	-1.4	1.8
Bone: cortical porosity	0.3	0.3	0.4	0.5	-0.6
Bone: cortical porosity	0.1	0.1	0.2	0.3	-0.4
Bone: cortical thickness	3.0	4.9	5.0	-2.2	2.2
Bone: cortical thickness	0.0	0.0	0.1	-0.2	0.1
Bone: cortical tissue density	0.3	0.4	0.4	-0.7	0.5
Condit. Reinf. active minus inactive responses	0.7	0.7	0.9	-0.9	0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	-0.4	0.4
Condit. Reinf. active responses	0.0	0.0	0.0	-0.1	0.0
Condit. Reinf. inactive responses	0.3	0.4	0.5	0.6	-0.7
Incentive salience index mean	0.2	0.2	0.3	-0.6	0.4
Condit. Reinf. lever presses	0.1	0.2	0.2	0.4	-0.5
Condit. Reinf. active minus inactive responses	0.3	0.4	0.7	-0.9	0.4
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.8	-0.9	0.6
Condit. Reinf. active responses	0.2	0.3	0.5	-0.7	0.3
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	-0.2
Condit. Reinf. lever presses	2.4	3.3	3.6	-1.9	1.7
Condit. Reinf. lever reinforcers received	0.4	0.6	0.8	-0.9	0.6
Conditioned reinforcement - actives	0.3	0.5	0.6	0.7	-0.8
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.5	-0.1
Conditioned locomotion	0.5	0.7	0.7	0.8	-0.8
Patch foraging indifference point 0 sec	0.4	0.7	0.8	-0.9	0.8
Patch foraging indifference point AUC	1.7	2.5	3.1	-1.8	1.3
Delay disc. indifference point, 0s delay	1.2	1.3	1.8	-0.9	1.4
Delay disc. indifference point, 16s delay	1.6	1.8	2.8	-0.9	1.7
Delay disc. indifference point, 2s delay	2.7	3.0	3.3	-1.7	1.8
Delay disc. indifference point, 24s delay	0.7	0.8	0.8	0.9	-0.9
Delay disc. indifference point, 4s delay	0.4	0.4	0.6	-0.4	0.8
Delay disc. indifference point, 8s delay	0.6	0.7	0.8	-0.8	0.9
Indifference point function ln k	0.3	0.5	0.8	0.9	-0.5
Indifference point function log k	0.3	0.5	0.8	0.9	-0.5
Patch foraging total patch changes 0 sec	0.3	0.6	0.7	-0.8	0.7
Patch foraging total patch changes 12 sec	0.2	0.2	0.2	-0.4	0.5
Patch foraging total patch changes 18 sec	1.6	2.5	2.7	-1.6	1.5
Patch foraging total patch changes 24 sec	1.6	2.7	3.4	-1.8	1.4
Patch foraging total patch changes 6 sec	3.0	4.6	5.0	-2.2	2.1
Patch foraging time to switch 0 sec	1.2	2.5	2.8	1.7	-1.5
Patch foraging water rate 0 sec	1.5	3.2	3.2	-1.8	1.8
Patch foraging water rate 12 sec	0.1	0.2	0.2	0.4	-0.3
Patch foraging water rate 18 sec	0.3	0.5	0.7	0.8	-0.6
Patch foraging water rate 24 sec	0.3	0.5	0.7	-0.4	0.9
Patch foraging water rate 6 sec	1.3	1.9	2.0	-1.3	1.4
Seeking ratio, delayed vs. immediate footshock	1.7	2.1	2.1	-1.5	1.4
Distance traveled before self-admin	3.2	4.2	4.8	-2.2	1.9
Distance traveled after self-admin	0.0	0.1	0.1	-0.3	0.2
Extensor digitorum longus weight	0.7	2.9	3.2	1.8	-1.6
Bone: elastic displacement	3.0	3.5	3.5	-1.9	1.9
Bone: elastic work	9.2	12.0	12.6	-3.4	3.6
Bone: endosteal estimation	0.0	0.1	0.1	0.1	0.3
Bone: endosteal perimeter	0.0	0.1	0.1	0.3	0.2
Epididymis fat weight	7.5	25.5	29.1	5.4	-4.7
Delta time in closed arm before/after self-admin	3.0	2.8	3.1	-1.8	1.6
Delta time in open arm before/after self-admin	6.8	6.7	7.0	2.6	-2.5
Diff in mean of infusions in LGA sessions	0.5	0.6	0.7	0.9	-0.7
Delay discount exponential model param	1.4	1.5	2.1	1.0	-1.4
Extinction: sum of active levers before priming	1.1	1.2	1.4	1.0	-1.2
Active lever presses in extinction session 6	0.3	0.3	0.4	0.3	-0.7
Bone: final force	0.4	0.6	0.8	-0.6	0.9
Bone: final moment	0.4	0.7	0.9	-0.7	1.0
Food consumed during 24 hour testing period	0.2	0.3	0.4	-0.6	0.5
Glucose	1.2	1.9	2.3	-1.5	1.2
Heart weight	1.3	2.0	2.2	1.5	-1.3
Delay discount hyperbolic model param	1.9	2.1	2.7	1.2	-1.6
Intermittent access intake day 1-15 change	0.1	0.3	0.5	0.1	-0.7
Intermittent access intake escalation	0.2	0.4	0.6	0.3	-0.8
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.4	-0.0
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.2	-0.4	0.5
Intermitt. access day 15 inactive lever presses	0.3	0.7	0.7	-0.8	0.8
Intermitt. access escalation Index	0.7	1.0	1.3	1.2	-0.8
Intermittent access day 1 total infusions	0.1	0.2	0.4	0.6	-0.3
Intermittent access day 15 total infusions	1.1	1.7	1.9	1.2	-1.4
Intermittent access terminal intake (last 3 days)	1.4	1.8	1.9	1.3	-1.4
Intermittent access total infusions	0.7	0.8	1.0	0.8	-1.0
Intermittent access day 1 locomotion	0.1	0.1	0.1	0.3	-0.2
Intermittent access day 15 total locomotion	0.5	0.8	1.0	0.8	-1.0
Intermittent access total locomotion	0.9	1.0	1.2	0.9	-1.1
Intermittent access standard deviation	0.0	0.0	0.0	0.1	-0.2
Left kidney weight	0.0	0.1	0.2	0.5	-0.0
Right kidney weight	0.1	0.5	0.8	0.9	-0.5
Cocaine induced anxiety	0.2	0.3	0.4	-0.4	0.7
Post-drug Anxiety	0.2	0.2	0.3	0.3	-0.6
Baseline Anxiety	0.6	0.7	1.2	0.4	-1.1
Tail length	0.3	1.4	1.6	1.3	-1.0
Length with tail	0.4	1.9	2.7	1.6	-1.1
Length without tail	0.3	0.9	1.4	1.2	-0.7
Times rat made contact with spout	0.0	0.1	0.1	-0.3	0.1
Lifetime Intake	0.8	1.0	1.0	1.0	-1.0
Liver weight, left	5.1	8.4	8.6	2.9	-2.9
Liver weight, right	3.6	6.4	7.1	2.7	-2.4
Locomotor activity	0.0	0.0	0.0	-0.2	0.2
Locomotor testing distance	0.0	0.1	0.1	-0.3	0.2
Locomotor testing rearing	0.0	0.1	0.1	-0.4	-0.0
Locomotion in novel chamber	1.8	2.4	3.0	-1.7	1.3
Locomotion in novel chamber post-restriction	0.2	0.3	0.5	0.0	-0.7
Fecal boli incidents, locomotor time 1	1.7	2.5	3.1	1.4	-1.7
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	-0.2	0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.2	-0.3
Bouts of movement, locomotor time 1	0.6	0.7	0.8	-0.7	0.9
Total resting periods, locomotor time 1	0.2	0.2	0.2	-0.4	0.5
Rest time, locomotor task time 1	0.3	0.4	0.6	0.3	-0.8
Distance moved, locomotor task time 1	0.3	0.5	0.8	-0.5	0.9
Vertical activity count, locomotor time 1	0.1	0.2	0.4	-0.2	0.6
Time >=10cm from walls, locomotor time 2	0.8	1.2	1.4	1.2	-1.0
Bouts of movement, locomotor time 2	0.4	0.6	0.8	-0.7	0.9
Total resting periods, locomotor time 2	0.1	0.2	0.2	-0.4	0.5
Rest time, locomotor task time 2	0.2	0.2	0.4	-0.3	-0.6
Distance moved, locomotor task time 2	0.3	0.4	0.7	-0.3	0.8
Vertical activity count, locomotor time 2	0.5	0.8	1.4	-0.3	1.2
Light reinforcement 1	0.0	0.0	0.0	-0.1	0.1
Light reinforcement 2	0.4	0.6	0.6	-0.7	0.8
Bone: marrow area	0.0	0.1	0.1	0.1	0.4
Bone: maximum diameter	0.5	0.9	1.2	-0.7	1.1
Bone: maximum force	0.6	1.1	1.4	-0.9	1.2
Bone: maximum moment	0.7	1.2	1.6	-1.0	1.3
Mean time between licks in bursts	0.4	0.9	1.0	1.0	-0.9
Mean num. licks in bursts	0.3	0.4	0.4	0.6	-0.6
Cd content in liver	0.9	0.9	1.2	-0.8	1.1
Co content in liver	0.3	0.3	0.5	-0.7	0.5
Cu content in liver	1.8	2.1	2.2	-1.5	1.5
Fe content in liver	2.3	2.7	2.9	1.7	-1.6
K content in liver	0.1	0.1	0.1	0.3	-0.3
Mg content in liver	0.7	0.7	0.7	-0.8	0.8
Mn content in liver	0.2	0.2	0.3	-0.6	0.4
Na content in liver	0.1	0.1	0.2	0.4	-0.1
Rb content in liver	0.1	0.1	0.1	0.3	-0.3
Se content in liver	0.6	0.7	0.7	-0.8	0.8
Sr content in liver	0.4	0.4	0.4	0.5	-0.7
Zn content in liver	0.3	0.4	0.5	0.7	-0.5
Bone: minimum diameter	0.1	0.2	0.3	-0.3	0.6
Time in familiar zone, hab. session 1	0.4	0.4	0.4	-0.6	0.7
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.4	-0.5
Total zone transitions, hab. session 1	0.1	0.1	0.1	-0.1	0.4
Total locomotion distance, hab. session 1	0.1	0.1	0.1	-0.4	0.4
Locomotion velocity, hab. session 1	0.3	0.5	0.5	-0.7	0.7
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.5	0.2
Time in novel zone, hab. session 2	0.2	0.2	0.3	-0.3	0.5
Total zone transitions, hab. session 2	0.2	0.3	0.4	0.6	-0.5
Total locomotion distance, hab. session 2	0.1	0.1	0.1	-0.3	0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.1	-0.4	0.3
Novel to familiar place preference ratio	0.8	0.9	1.0	1.0	-0.9
Novelty place preference	1.1	1.2	1.3	1.1	-1.0
Time in novel zone, NPP test	1.2	1.3	1.4	1.2	-1.1
Total zone transitions, NPP test	0.0	0.0	0.0	0.1	-0.0
Total locomotion distance, NPP test	0.9	1.2	1.3	-1.1	1.1
Locomotion velocity, NPP test	1.0	1.5	1.5	-1.2	1.2
Intraocular pressure	1.0	1.5	1.7	-1.3	1.1
Delta distance traveled before/after self-admin	3.0	3.1	3.4	1.8	-1.7
Delta ambulatory time before/after self-admin	2.1	2.6	2.8	1.7	-1.5
Parametrial fat weight	5.9	13.9	14.5	3.8	-3.6
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.1	-0.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.2	-0.1
Pavlov. Cond. change in total contacts	0.2	0.3	0.3	-0.6	0.4
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	0.0	-0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.0	-0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.3	-0.6	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.2	0.2
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.0	0.1
Pavlov. Cond. lever latency	2.5	3.4	3.6	1.9	-1.8
Pavlov. Cond. magazine entry latency	0.2	0.2	0.2	-0.5	0.4
Pavlov. Cond. change in total contacts	1.3	2.1	2.2	-1.5	1.4
Pavlov. Cond. index score	2.2	3.0	3.2	-1.8	1.7
Pavlov. Cond. latency score	2.6	3.4	3.7	-1.9	1.8
Pavlov. Cond. lever contacts	1.4	1.9	2.1	-1.4	1.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.6	0.6	0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.2	2.4	-1.5	1.4
Pavlov. Cond. response bias	1.2	1.6	1.7	-1.3	1.2
Time in closed arm before self-admin	1.6	2.0	2.2	1.5	-1.4
Time in closed arm after self-admin	0.8	0.9	1.1	-0.7	1.1
Time in open arm before self-admin	2.1	2.2	2.6	-1.6	1.4
Time in open arm after self-admin	1.0	1.1	1.1	1.0	-1.1
Bone: periosteal estimation	0.5	1.1	1.5	-0.8	1.2
Bone: periosteal perimeter	0.4	0.7	1.2	-0.5	1.1
Bone: post-yield work	0.3	0.4	0.4	0.7	-0.6
Progressive ratio test 1 active lever presses	0.2	0.3	0.4	-0.6	0.4
Progressive ratio test 1 breakpoint	0.3	0.4	0.5	-0.7	0.5
Progressive ratio test 1 inactive lever presses	1.4	2.0	2.4	-1.3	1.5
Progressive ratio test 2 active lever presses	0.2	0.2	0.3	-0.6	0.4
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	-0.6	0.3
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	-0.3	0.4
Incentive Sensitization - Responses	0.0	0.0	0.0	0.1	-0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.1	-0.2
Sum of active levers in priming session hrs 5-6	1.5	1.4	1.4	1.2	-1.2
Progressive ratio	0.1	0.1	0.2	0.0	-0.5
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.3	-0.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	-0.1	0.5
Retroperitoneal fat weight	0.5	2.0	2.5	1.6	-1.2
Reaction time number correct	0.6	1.1	1.3	1.2	-1.0
Reaction time mean minus median	0.2	0.4	0.5	0.5	-0.7
Reaction time mean minus median AUC	1.0	2.6	2.7	1.6	-1.6
Reaction time num false alarms	5.7	8.0	8.5	-2.9	2.7
Reaction time num false alarms AUC	5.3	8.3	8.7	-2.9	2.8
Reaction time trials correct on left	0.6	1.1	1.3	1.2	-1.0
Reaction time trials on left	0.6	1.2	1.4	1.2	-1.0
Reaction time mean	0.6	1.0	1.0	1.0	-1.0
Reaction time mean AUC	0.5	0.7	0.8	0.9	-0.8
Median of all reaction times	0.4	0.6	0.7	0.8	-0.8
Reaction time omissions	1.4	2.0	2.1	1.4	-1.5
Reaction time false alarm rate	6.0	8.3	8.9	-3.0	2.8
Reaction time premature initiation rate	0.2	0.2	0.3	0.6	-0.4
Reaction time premature initiations	0.3	0.5	0.7	0.8	-0.6
Std. dev. reaction times	0.7	1.3	1.4	1.1	-1.2
Reaction time trials completed	0.6	1.2	1.4	1.2	-1.0
Reaction time trials AUC	0.5	1.0	1.1	1.0	-0.9
Run reversals in cocaine runway, females	0.0	0.0	0.1	0.2	0.2
Run reversals in cocaine runway, males	0.2	0.2	0.3	0.3	-0.6
Latency to leave start box in cocaine runway	0.4	0.5	0.8	-0.9	0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.4	0.1
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	-0.6	0.2
Std. dev. time between licks in bursts	0.0	0.0	0.0	0.2	0.0
Total sessions with >9 infusions	0.4	0.4	0.7	0.8	-0.4
Short access day 1 total inactive lever presses	3.5	4.6	5.3	2.3	-2.0
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.0	0.1
Short access day 1 total infusions	0.6	0.8	1.2	1.1	-0.7
Short access day 10 total infusions	0.4	0.4	0.6	0.8	-0.5
Short access total infusions	0.2	0.3	0.4	0.6	-0.4
Short access day 1 locomotion	0.0	0.0	0.0	0.1	0.2
Short access day 10 total locomotion	0.3	0.5	0.6	-0.8	0.7
Short access total locomotion	0.4	0.5	0.6	-0.6	0.8
One hour access (0.3 mA shock)	0.0	0.0	0.0	-0.1	-0.1
Compulsive drug intake	0.9	1.0	1.2	1.1	-0.9
One hour access (shock baseline)	0.0	0.1	0.1	-0.4	0.0
Social response proportion	2.2	2.5	3.1	1.7	-1.4
Social responses	2.0	2.5	2.7	1.6	-1.5
Social time	1.7	2.3	2.4	1.5	-1.5
Soleus weight	2.3	6.7	7.0	2.6	-2.5
Bone: stiffness	1.9	3.0	3.3	1.8	-1.7
Tibialis anterior weight	2.7	9.1	9.8	3.1	-2.9
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.4	-0.0
Time to tail flick, vehicle, after self-admin	0.4	0.5	0.5	-0.6	0.7
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.0	-0.2
Time to tail flick, test, after self-admin	0.4	0.4	0.8	-0.9	0.2
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	-0.7	0.4
Delta time to tail flick, test, before/after SA	0.5	0.5	0.6	-0.8	0.6
Tibia length	0.0	0.1	0.1	-0.2	0.3
Ambulatory time before self-admin	1.5	2.2	2.5	-1.4	1.6
Ambulatory time after self-admin	0.0	0.0	0.0	0.1	0.0
Bone: tissue strength	1.8	1.8	1.9	-1.3	1.4
Total heroin consumption	3.3	3.9	4.6	1.8	-2.1
Bone: trabecular number	3.2	5.3	5.7	2.2	-2.4
Bone: trabecular spacing	0.3	0.4	0.4	-0.6	0.6
Bone: trabecular thickness	0.0	0.0	0.0	0.0	0.2
Bone: trabecular tissue density	1.4	2.1	2.2	-1.4	1.5
Water consumed over 24 hours	0.0	0.1	0.1	-0.2	0.3
Number of responses in last shaping day	1.5	1.6	2.1	-1.1	1.4