Hub : Genes

Slc39a3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Slc39a3 0.08 0.06 8.0e-04 0.07 0.07 0.06 0.07 5.8e-04 5.0e-04 1.1e-03 3.8e-04
2 NAcc gene expression Slc39a3 0.09 0.06 1.3e-13 0.12 0.12 0.12 0.12 5.7e-14 8.0e-14 4.3e-14 1.1e-13
3 Adipose gene expression Slc39a3 0.09 0.06 9.1e-12 0.09 0.09 0.08 0.09 6.0e-10 6.0e-10 2.8e-09 9.9e-10
4 Liver gene expression Slc39a3 0.17 0.1 0.0e+00 0.18 0.18 0.18 0.18 5.0e-20 2.2e-19 1.1e-19 1.0e-19
5 Brain gene expression Slc39a3 0.15 0.11 1.3e-12 0.12 0.11 0.11 0.12 6.4e-11 1.0e-10 1.7e-10 4.3e-11
6 PL mRNA stability Slc39a3 0.02 0.01 3.6e-03 0.02 0.02 0.03 0.02 1.4e-03 1.2e-03 8.9e-04 1.2e-03
7 NAcc mRNA stability Slc39a3 0.02 0.01 8.2e-03 0 0 0 -0 6.7e-02 2.4e-01 1.3e-01 4.0e-01
8 PL gene expression Slc39a3 0.03 0.03 2.6e-05 0.04 0.04 0.04 0.04 8.9e-06 3.4e-05 4.1e-05 3.1e-05
9 Brain mRNA stability Slc39a3 0.04 0.03 6.5e-04 0.02 0.01 0.01 0.01 1.2e-02 2.6e-02 2.5e-02 5.1e-02
10 LHb mRNA stability Slc39a3 0.13 0.11 6.4e-03 0.09 0.06 0.1 0.07 3.5e-03 1.3e-02 2.7e-03 7.9e-03
11 RMTg gene expression Slc39a3 0.27 0.16 5.7e-03 0.08 0.05 0.11 0.07 3.5e-03 2.2e-02 9.2e-04 7.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.71.27.50.00.20.60.6-0.60.70.70.70.71.52.7
Area under the delay curve2.52.63.3-1.71.71.61.6-1.61.71.81.71.61.70.7
BMI with tail5.818.723.5-4.84.74.64.6-4.64.54.64.54.53.9-0.4
BMI without tail1.83.76.1-2.52.22.02.0-2.01.91.91.91.91.4-1.1
Body weight1.04.25.3-2.32.22.22.2-2.12.12.12.12.11.8-0.2
Weight adjusted by age0.20.21.1-0.70.50.40.4-0.30.30.30.30.30.0-1.0
Bone surface1.01.815.70.6-0.40.30.3-0.30.40.40.40.41.64.0
Bone volume1.01.815.70.6-0.40.30.3-0.30.40.40.40.41.64.0
Breakpoint value in progressive ratio session5.45.96.92.3-2.6-2.6-2.62.6-2.6-2.5-2.6-2.6-2.4-0.9
Number of licking bursts0.20.21.9-0.30.0-0.2-0.20.0-0.1-0.1-0.1-0.1-0.5-1.4
Context. condit. distance diff. score0.20.30.4-0.60.60.50.5-0.60.60.60.60.60.5-0.2
Locomotion velocity, session 10.40.51.70.9-0.7-0.5-0.50.6-0.5-0.6-0.5-0.6-0.11.3
Locomotion distance, session 10.30.43.40.6-0.10.10.1-0.10.20.20.20.10.71.8
Locomotion velocity, session 22.52.95.42.3-1.9-1.6-1.61.6-1.6-1.7-1.6-1.8-0.91.8
Locomotion distance, session 21.01.43.91.7-1.3-1.0-1.00.9-1.0-1.0-1.0-1.1-0.32.0
Locomotion velocity, session 35.86.88.02.8-2.7-2.7-2.72.8-2.7-2.7-2.8-2.8-2.5-0.2
Locomotion distance, session 30.00.00.1-0.2-0.0-0.1-0.10.20.00.00.0-0.1-0.1-0.3
Stereotopy head waving bouts, day 34.04.76.92.6-2.4-2.2-2.22.2-2.3-2.2-2.3-2.3-1.80.6
Stereotopy head waving duration, day 35.06.08.22.9-2.6-2.5-2.52.5-2.6-2.6-2.6-2.6-2.20.4
Locomotion velocity, session 70.60.70.90.8-0.9-0.8-0.80.8-0.9-0.9-0.9-0.9-0.70.5
Locomotion distance, session 70.10.10.8-0.50.20.10.1-0.00.10.00.10.0-0.2-0.9
Stereotopy head waving bouts, day 70.20.32.10.10.10.30.3-0.20.30.30.30.30.71.4
Stereotopy head waving duration, day 70.30.32.70.6-0.4-0.1-0.10.1-0.1-0.1-0.1-0.10.41.6
Locomotion velocity, session 80.50.53.90.9-0.6-0.3-0.30.3-0.4-0.3-0.4-0.40.32.0
Locomotion distance, session 80.10.10.40.5-0.3-0.2-0.20.1-0.2-0.2-0.2-0.30.00.7
Degree of sensitization distance0.30.30.5-0.60.60.60.6-0.70.60.50.60.60.50.1
Degree of sensitization stereotypy2.32.63.5-1.41.51.61.6-1.61.71.71.71.71.91.2
Conditioned locomotion1.01.22.2-1.31.31.11.1-1.10.91.00.90.90.4-1.5
Cocaine response after cond. corrected3.74.17.1-2.72.42.02.0-2.12.12.02.02.01.2-1.5
Cocaine response after cond. not corrected3.94.37.4-2.72.42.12.1-2.22.12.02.12.01.2-1.6
Cocaine response before conditioning0.40.40.70.8-0.8-0.6-0.60.7-0.7-0.7-0.7-0.6-0.50.5
Saline control response0.00.00.2-0.20.20.20.2-0.20.20.10.20.0-0.1-0.4
Bone: connectivity density0.81.34.5-0.50.61.01.0-0.91.01.01.11.01.52.1
Bone: cortical apparent density0.71.01.4-1.11.01.01.0-1.21.01.01.01.00.9-0.0
Bone: cortical area0.91.42.6-0.80.91.11.1-1.21.11.11.11.11.51.6
Bone: cortical porosity0.40.40.80.9-0.7-0.6-0.60.7-0.6-0.5-0.6-0.5-0.20.7
Bone: cortical porosity0.20.21.50.3-0.10.10.1-0.10.10.20.10.30.61.2
Bone: cortical thickness1.22.02.5-1.21.41.51.5-1.61.41.51.41.51.60.8
Bone: cortical thickness0.10.10.8-0.1-0.1-0.3-0.30.2-0.3-0.3-0.3-0.3-0.5-0.9
Bone: cortical tissue density0.50.60.9-0.90.90.80.8-1.00.80.80.80.80.7-0.1
Condit. Reinf. active minus inactive responses3.74.14.92.2-2.2-2.2-2.22.1-2.1-2.2-2.2-2.1-1.80.1
Condit. Reinf. active-inactive response ratio2.32.52.81.5-1.6-1.7-1.71.7-1.6-1.7-1.7-1.6-1.7-0.7
Condit. Reinf. active responses2.83.45.42.3-2.1-1.9-1.91.9-1.9-1.9-1.9-1.9-1.41.0
Condit. Reinf. inactive responses0.60.71.91.2-0.9-0.7-0.70.6-0.7-0.7-0.7-0.7-0.11.4
Incentive salience index mean1.62.03.11.8-1.6-1.5-1.51.4-1.4-1.4-1.5-1.4-0.90.9
Condit. Reinf. lever presses0.40.54.10.30.00.20.2-0.30.40.40.30.41.02.0
Condit. Reinf. active minus inactive responses2.63.33.91.6-1.8-1.9-1.91.9-1.9-1.9-1.9-1.8-2.0-1.1
Condit. Reinf. active-inactive response ratio0.60.62.90.2-0.4-0.7-0.70.7-0.6-0.6-0.6-0.6-1.1-1.7
Condit. Reinf. active responses2.12.93.51.7-1.9-1.9-1.91.8-1.8-1.8-1.8-1.8-1.6-0.2
Condit. Reinf. inactive responses0.91.11.61.3-1.3-1.1-1.11.0-1.1-1.1-1.1-1.0-0.70.7
Condit. Reinf. lever presses2.63.64.21.7-1.9-2.0-2.02.0-2.0-2.0-2.0-2.0-2.1-0.9
Condit. Reinf. lever reinforcers received1.72.42.91.4-1.6-1.7-1.71.7-1.6-1.6-1.6-1.6-1.6-0.5
Conditioned reinforcement - actives2.02.03.11.4-1.8-1.7-1.71.6-1.5-1.3-1.4-1.3-1.10.0
Conditioned reinforcement - inactives0.40.40.8-0.80.70.60.6-0.60.60.70.60.70.2-0.9
Conditioned locomotion6.78.110.52.9-3.2-3.2-3.23.2-3.0-2.8-2.9-2.8-2.5-0.2
Patch foraging indifference point 0 sec0.20.20.4-0.40.40.50.5-0.60.50.50.50.50.50.4
Patch foraging indifference point AUC0.91.11.41.0-1.1-1.2-1.21.2-1.1-1.0-1.0-1.0-0.9-0.4
Delay disc. indifference point, 0s delay8.49.212.1-2.82.93.13.1-3.03.13.33.13.23.52.1
Delay disc. indifference point, 16s delay0.20.20.3-0.50.50.40.4-0.50.40.40.50.40.40.2
Delay disc. indifference point, 2s delay6.26.98.4-2.72.62.72.7-2.72.72.92.72.82.81.2
Delay disc. indifference point, 24s delay0.50.50.9-0.80.90.80.8-0.80.80.60.80.70.5-0.2
Delay disc. indifference point, 4s delay1.61.72.3-1.31.21.31.3-1.31.31.41.31.21.51.2
Delay disc. indifference point, 8s delay0.90.91.4-1.21.21.01.0-0.91.01.11.01.00.8-0.4
Indifference point function ln k0.20.30.5-0.70.50.60.5-0.60.60.50.60.50.40.0
Indifference point function log k0.20.30.5-0.70.50.60.5-0.60.60.50.60.50.40.0
Patch foraging total patch changes 0 sec0.10.20.3-0.40.40.40.4-0.50.40.40.40.40.30.2
Patch foraging total patch changes 12 sec0.20.20.9-0.60.60.40.4-0.50.40.30.40.40.0-1.0
Patch foraging total patch changes 18 sec1.11.41.61.3-1.2-1.2-1.21.2-1.2-1.3-1.2-1.3-1.1-0.2
Patch foraging total patch changes 24 sec0.10.10.10.3-0.3-0.3-0.30.2-0.3-0.3-0.3-0.2-0.20.1
Patch foraging total patch changes 6 sec0.20.30.60.8-0.6-0.6-0.60.4-0.6-0.6-0.6-0.6-0.50.1
Patch foraging time to switch 0 sec1.82.73.5-1.11.61.81.9-1.91.61.71.51.61.81.4
Patch foraging water rate 0 sec0.30.42.5-0.3-0.3-0.6-0.70.5-0.3-0.3-0.3-0.3-0.8-1.6
Patch foraging water rate 12 sec0.60.92.8-1.41.10.80.7-0.80.80.80.80.70.2-1.7
Patch foraging water rate 18 sec1.11.58.0-0.1-0.5-1.0-1.00.8-0.8-0.9-0.8-0.8-1.6-2.8
Patch foraging water rate 24 sec0.71.08.7-1.00.4-0.1-0.20.10.00.00.10.0-1.0-2.9
Patch foraging water rate 6 sec0.91.33.70.4-0.8-1.1-1.11.1-1.0-1.1-1.0-1.1-1.5-1.9
Seeking ratio, delayed vs. immediate footshock3.84.45.82.3-2.4-2.2-2.22.3-2.1-2.2-2.1-2.1-1.70.6
Distance traveled before self-admin0.50.50.9-0.80.60.50.5-0.50.90.90.90.90.90.5
Distance traveled after self-admin0.60.61.00.8-0.9-1.0-1.01.0-0.8-0.7-0.7-0.8-0.50.3
Extensor digitorum longus weight3.815.120.9-4.64.43.93.9-3.94.14.24.14.23.2-1.5
Bone: elastic displacement0.20.20.40.5-0.6-0.5-0.50.6-0.5-0.5-0.5-0.5-0.40.1
Bone: elastic work0.30.30.5-0.60.50.60.6-0.60.60.50.60.50.70.7
Bone: endosteal estimation0.30.60.9-0.70.70.80.8-0.80.80.80.80.80.90.9
Bone: endosteal perimeter0.20.41.80.7-0.7-0.4-0.40.4-0.4-0.5-0.4-0.5-0.01.3
Epididymis fat weight0.30.60.90.6-0.6-0.8-0.80.8-0.8-0.8-0.8-0.8-0.9-0.9
Delta time in closed arm before/after self-admin0.70.74.9-1.10.60.30.3-0.20.30.40.40.4-0.3-2.2
Delta time in open arm before/after self-admin1.11.11.5-0.91.21.21.2-1.21.11.01.11.11.00.5
Diff in mean of infusions in LGA sessions1.61.82.21.4-1.4-1.4-1.41.4-1.4-1.5-1.4-1.5-1.3-0.2
Delay discount exponential model param2.22.32.91.7-1.6-1.5-1.51.5-1.6-1.7-1.6-1.5-1.6-0.6
Extinction: sum of active levers before priming1.61.61.90.8-1.3-1.4-1.41.3-1.3-1.1-1.2-1.2-1.4-1.4
Active lever presses in extinction session 62.52.43.41.6-1.8-1.8-1.81.7-1.6-1.5-1.6-1.6-1.30.1
Bone: final force1.52.53.4-1.31.41.61.6-1.71.61.61.51.61.81.4
Bone: final moment1.22.02.8-1.11.31.41.4-1.51.41.41.41.41.71.3
Food consumed during 24 hour testing period0.50.71.2-1.10.80.70.7-0.80.80.90.90.90.8-0.1
Glucose1.21.82.5-1.61.51.31.3-1.31.41.41.51.41.2-0.2
Heart weight0.50.71.00.7-0.7-0.8-0.80.9-0.8-0.8-0.9-0.9-1.0-0.9
Delay discount hyperbolic model param3.13.34.12.0-1.9-1.9-1.91.8-1.9-2.0-1.9-1.9-1.9-0.7
Intermittent access intake day 1-15 change6.86.78.02.6-2.8-2.8-2.82.8-2.7-2.7-2.7-2.6-2.6-0.7
Intermittent access intake escalation7.47.38.62.4-2.8-2.9-2.92.9-2.8-2.8-2.7-2.7-2.9-1.6
Intermittent access intake escalation 29.29.110.52.8-3.0-3.2-3.23.2-3.1-3.1-3.1-3.1-3.2-1.6
Intermitt. access day 1 inactive lever presses0.40.50.90.2-0.6-0.9-0.90.9-0.6-0.5-0.5-0.5-0.7-1.0
Intermitt. access day 15 inactive lever presses0.60.70.90.8-0.8-0.8-0.80.7-0.9-0.8-0.9-0.8-0.9-0.6
Intermitt. access escalation Index0.70.61.8-0.30.50.70.7-0.80.80.70.80.81.11.3
Intermittent access day 1 total infusions0.10.10.2-0.20.20.30.3-0.40.20.30.20.30.30.2
Intermittent access day 15 total infusions2.22.42.91.4-1.7-1.7-1.71.5-1.7-1.6-1.7-1.6-1.7-0.9
Intermittent access terminal intake (last 3 days)1.11.21.61.1-1.3-1.2-1.21.0-1.2-1.1-1.2-1.1-1.0-0.3
Intermittent access total infusions0.20.30.40.4-0.6-0.6-0.60.4-0.6-0.5-0.5-0.5-0.5-0.4
Intermittent access day 1 locomotion0.40.40.50.6-0.7-0.6-0.60.5-0.7-0.6-0.7-0.6-0.7-0.4
Intermittent access day 15 total locomotion3.63.84.62.0-2.1-2.2-2.22.0-2.1-2.0-2.0-2.0-1.9-0.7
Intermittent access total locomotion0.91.01.51.0-1.2-1.2-1.21.0-1.0-0.9-1.0-0.9-0.8-0.2
Intermittent access standard deviation3.23.44.31.8-2.0-2.1-2.12.0-2.0-1.8-1.9-1.8-1.8-0.8
Left kidney weight0.00.11.10.3-0.2-0.0-0.00.1-0.1-0.1-0.1-0.00.31.0
Right kidney weight1.33.54.72.2-2.1-2.0-2.02.0-2.0-2.0-2.0-2.0-1.60.3
Cocaine induced anxiety0.50.51.41.0-0.8-0.6-0.60.7-0.7-0.5-0.7-0.5-0.01.2
Post-drug Anxiety0.40.52.51.0-0.5-0.3-0.30.4-0.6-0.5-0.7-0.60.11.6
Baseline Anxiety0.30.30.60.4-0.2-0.3-0.30.2-0.5-0.6-0.6-0.7-0.8-0.7
Tail length3.29.711.23.1-3.2-3.3-3.33.3-3.2-3.3-3.2-3.3-3.2-0.9
Length with tail1.76.27.82.8-2.8-2.6-2.62.7-2.6-2.6-2.6-2.6-2.30.4
Length without tail0.10.22.00.5-0.30.00.00.1-0.0-0.1-0.0-0.00.31.4
Times rat made contact with spout0.10.20.7-0.60.40.30.3-0.30.30.30.30.30.0-0.9
Lifetime Intake0.10.10.20.2-0.4-0.3-0.30.1-0.4-0.2-0.3-0.2-0.2-0.2
Liver weight, left2.03.24.3-2.02.11.91.9-1.81.81.81.81.81.4-0.7
Liver weight, right1.72.73.3-1.71.81.81.8-1.71.71.81.71.81.60.2
Locomotor activity2.64.16.32.5-2.4-2.1-2.12.0-2.1-2.0-2.0-2.0-1.41.3
Locomotor testing distance1.62.73.82.0-2.0-1.7-1.71.6-1.7-1.7-1.7-1.7-1.30.8
Locomotor testing rearing0.10.10.20.1-0.3-0.3-0.30.3-0.4-0.4-0.4-0.4-0.5-0.5
Locomotion in novel chamber0.40.50.70.5-0.7-0.8-0.80.8-0.7-0.6-0.6-0.7-0.7-0.8
Locomotion in novel chamber post-restriction0.70.81.10.8-1.0-0.9-1.00.9-1.0-1.0-1.0-1.0-0.9-0.1
Fecal boli incidents, locomotor time 11.21.31.7-1.21.31.21.2-1.21.21.21.11.20.8-1.0
Change in fecal boli incidents, locomotor task0.30.31.90.4-0.6-0.3-0.30.4-0.3-0.3-0.4-0.30.21.4
Time >=10cm from walls, locomotor time 10.50.51.0-0.30.60.60.6-0.80.70.70.70.70.91.0
Bouts of movement, locomotor time 10.20.20.30.5-0.4-0.5-0.50.4-0.5-0.5-0.5-0.5-0.5-0.3
Total resting periods, locomotor time 10.20.20.30.6-0.5-0.6-0.60.4-0.5-0.5-0.5-0.5-0.5-0.1
Rest time, locomotor task time 10.20.20.30.4-0.5-0.5-0.50.4-0.4-0.4-0.4-0.4-0.20.3
Distance moved, locomotor task time 10.70.81.6-0.60.70.90.9-0.80.80.80.90.81.11.3
Vertical activity count, locomotor time 10.00.00.2-0.40.20.20.2-0.10.10.20.10.20.0-0.2
Time >=10cm from walls, locomotor time 20.80.81.2-1.11.10.80.8-1.01.00.91.00.90.6-0.6
Bouts of movement, locomotor time 20.30.31.30.8-0.5-0.4-0.40.4-0.3-0.4-0.3-0.40.01.1
Total resting periods, locomotor time 20.30.31.50.8-0.5-0.4-0.40.3-0.2-0.3-0.2-0.30.11.2
Rest time, locomotor task time 20.40.40.80.9-0.7-0.7-0.70.4-0.6-0.6-0.6-0.6-0.30.7
Distance moved, locomotor task time 20.60.61.1-1.10.90.80.8-0.80.80.80.80.80.4-0.8
Vertical activity count, locomotor time 20.50.51.7-1.00.70.50.5-0.50.60.60.50.60.1-1.3
Light reinforcement 15.09.212.43.5-3.3-3.1-3.13.1-3.2-3.2-3.2-3.2-2.80.2
Light reinforcement 21.62.23.11.7-1.6-1.5-1.51.5-1.6-1.6-1.6-1.5-1.40.2
Bone: marrow area0.30.60.9-0.70.70.80.8-0.80.80.80.80.80.90.9
Bone: maximum diameter0.50.92.71.2-1.1-0.8-0.80.7-0.8-0.8-0.8-0.8-0.21.7
Bone: maximum force1.42.43.0-1.41.51.61.6-1.71.61.51.51.51.71.2
Bone: maximum moment1.12.02.5-1.31.31.51.5-1.61.41.41.41.41.61.1
Mean time between licks in bursts4.46.17.32.5-2.5-2.6-2.62.5-2.6-2.6-2.6-2.7-2.6-0.8
Mean num. licks in bursts0.10.10.3-0.10.20.30.3-0.20.30.30.30.30.40.5
Cd content in liver0.20.20.3-0.40.50.50.5-0.50.50.50.50.50.50.2
Co content in liver0.60.71.00.8-0.8-0.9-0.90.9-0.8-0.9-0.9-0.9-1.0-0.5
Cu content in liver0.30.41.6-0.20.30.50.5-0.50.60.50.60.50.81.3
Fe content in liver0.10.10.50.1-0.1-0.2-0.20.2-0.3-0.3-0.3-0.3-0.5-0.7
K content in liver0.20.21.40.10.10.20.2-0.20.40.30.40.30.61.2
Mg content in liver0.30.32.00.10.10.20.2-0.20.40.30.40.30.81.4
Mn content in liver0.80.96.41.1-0.9-0.5-0.50.5-0.4-0.5-0.4-0.50.42.5
Na content in liver1.31.41.8-0.91.11.21.2-1.21.31.21.41.21.30.9
Rb content in liver0.81.02.3-0.60.70.90.9-0.91.01.00.91.01.41.5
Se content in liver0.10.10.20.4-0.5-0.4-0.40.4-0.3-0.3-0.3-0.3-0.20.2
Sr content in liver0.20.21.6-0.1-0.1-0.3-0.30.3-0.2-0.2-0.2-0.2-0.6-1.3
Zn content in liver2.83.14.21.2-1.5-1.9-1.91.9-1.7-1.6-1.7-1.6-2.0-2.0
Bone: minimum diameter0.10.21.4-0.10.10.30.3-0.30.30.30.30.30.61.2
Time in familiar zone, hab. session 12.52.43.01.5-1.5-1.5-1.51.5-1.7-1.7-1.7-1.7-1.7-0.5
Time in novel zone, hab. session 11.61.62.6-1.11.01.11.1-1.21.31.31.31.31.61.3
Total zone transitions, hab. session 10.60.82.21.2-1.0-0.8-0.80.7-0.7-0.8-0.8-0.8-0.21.5
Total locomotion distance, hab. session 10.81.15.81.4-1.0-0.6-0.60.6-0.7-0.8-0.7-0.80.12.4
Locomotion velocity, hab. session 11.01.43.61.7-1.3-1.0-1.01.0-1.0-1.1-1.1-1.1-0.31.9
Time in familiar zone, hab. session 26.97.18.22.6-2.7-2.7-2.72.8-2.8-2.8-2.8-2.9-2.9-1.2
Time in novel zone, hab. session 25.45.46.6-2.22.32.42.4-2.42.42.42.42.52.61.4
Total zone transitions, hab. session 20.70.93.7-0.10.60.80.8-0.90.80.80.80.71.31.9
Total locomotion distance, hab. session 20.60.82.01.4-0.9-0.7-0.70.7-0.8-0.8-0.8-0.8-0.31.3
Locomotion velocity, hab. session 20.60.82.91.4-0.9-0.6-0.60.6-0.7-0.7-0.7-0.7-0.11.7
Novel to familiar place preference ratio5.05.27.0-2.12.12.32.3-2.22.42.42.42.52.61.6
Novelty place preference3.33.34.7-1.61.61.81.8-1.71.91.91.92.02.21.5
Time in novel zone, NPP test3.53.64.9-1.81.81.91.9-1.82.02.02.02.12.21.4
Total zone transitions, NPP test0.10.20.90.30.20.30.3-0.40.20.20.20.10.51.0
Total locomotion distance, NPP test0.30.42.00.20.30.50.5-0.50.40.40.40.30.71.4
Locomotion velocity, NPP test0.20.21.80.5-0.00.20.2-0.20.10.10.10.00.51.3
Intraocular pressure0.40.53.2-0.1-0.2-0.4-0.40.5-0.5-0.5-0.5-0.5-0.9-1.8
Delta distance traveled before/after self-admin1.61.72.31.5-1.4-1.3-1.31.3-1.4-1.4-1.5-1.5-1.30.1
Delta ambulatory time before/after self-admin1.51.72.31.5-1.4-1.3-1.31.3-1.4-1.3-1.4-1.5-1.00.4
Parametrial fat weight0.50.91.10.8-1.0-1.0-1.01.1-1.0-1.0-1.0-1.0-1.0-0.4
Pavlov. Cond. lever latency0.20.31.9-0.1-0.1-0.4-0.40.3-0.3-0.4-0.3-0.4-0.8-1.4
Pavlov. Cond. magazine entry latency2.83.64.32.1-2.0-2.0-2.01.9-2.0-2.0-2.0-2.0-1.9-0.4
Pavlov. Cond. change in total contacts0.00.00.10.3-0.2-0.2-0.20.2-0.2-0.1-0.2-0.1-0.10.1
Pavlov. Cond. index score0.30.30.70.9-0.6-0.5-0.50.5-0.6-0.5-0.6-0.4-0.10.8
Pavlov. Cond. latency score0.30.31.50.9-0.6-0.4-0.40.4-0.4-0.3-0.5-0.30.11.2
Pavlov. Cond. lever contacts0.30.32.60.3-0.10.20.2-0.10.20.40.10.30.81.6
Pavlov. Cond. magazine entry number0.60.71.0-1.00.90.90.9-0.80.90.90.90.80.8-0.0
Pavlov. Cond. intertrial magazine entries0.30.41.10.3-0.4-0.6-0.60.4-0.6-0.6-0.5-0.6-0.8-1.0
Pavlov. Cond. lever-magazine prob. diff.0.50.71.31.1-0.9-0.8-0.80.8-0.8-0.7-0.9-0.7-0.40.7
Pavlov. Cond. response bias0.91.11.61.3-1.2-1.1-1.11.1-1.2-1.1-1.2-1.0-0.90.1
Pavlov. Cond. lever latency0.81.01.3-1.01.11.01.0-1.11.11.11.21.00.9-0.2
Pavlov. Cond. magazine entry latency0.40.50.60.7-0.8-0.7-0.70.8-0.7-0.7-0.8-0.7-0.50.4
Pavlov. Cond. change in total contacts0.81.11.51.0-1.1-1.1-1.11.2-1.1-1.1-1.1-1.1-1.0-0.2
Pavlov. Cond. index score0.91.21.51.0-1.1-1.1-1.11.2-1.2-1.2-1.2-1.2-1.00.1
Pavlov. Cond. latency score0.81.01.21.0-1.1-1.0-1.01.1-1.1-1.1-1.1-1.1-0.80.3
Pavlov. Cond. lever contacts0.81.11.41.0-1.1-1.1-1.11.2-1.2-1.1-1.2-1.1-1.1-0.3
Pavlov. Cond. magazine entry number0.70.81.1-0.81.01.01.0-1.00.91.01.01.00.7-0.5
Pavlov. Cond. intertrial magazine entries0.20.30.6-0.60.60.40.4-0.70.40.40.40.40.1-0.8
Pavlov. Cond. lever-magazine prob. diff.0.91.11.41.0-1.1-1.1-1.11.2-1.1-1.2-1.2-1.2-0.90.2
Pavlov. Cond. response bias1.92.63.21.5-1.7-1.7-1.71.8-1.7-1.7-1.8-1.7-1.7-0.4
Time in closed arm before self-admin1.21.42.0-0.71.01.31.3-1.21.21.21.21.21.41.4
Time in closed arm after self-admin0.00.00.00.0-0.1-0.1-0.10.2-0.2-0.1-0.1-0.1-0.2-0.2
Time in open arm before self-admin0.90.91.50.7-1.1-1.2-1.21.2-0.9-0.9-0.9-0.9-0.9-0.5
Time in open arm after self-admin0.60.70.9-0.90.90.80.8-0.80.90.80.90.90.6-0.2
Bone: periosteal estimation0.61.33.1-0.70.81.11.1-1.21.11.11.01.11.51.7
Bone: periosteal perimeter0.20.32.90.3-0.20.00.0-0.10.00.00.0-0.00.51.7
Bone: post-yield work0.50.61.0-0.90.90.80.8-1.00.80.80.80.80.7-0.0
Progressive ratio test 1 active lever presses0.10.10.3-0.40.20.20.2-0.30.10.20.20.20.0-0.5
Progressive ratio test 1 breakpoint0.10.10.2-0.50.40.30.3-0.50.30.30.30.30.2-0.4
Progressive ratio test 1 inactive lever presses0.00.00.00.1-0.1-0.1-0.10.0-0.10.0-0.00.00.00.0
Progressive ratio test 2 active lever presses0.30.30.50.3-0.6-0.7-0.70.6-0.6-0.5-0.5-0.5-0.6-0.7
Progressive ratio test 2 breakpoint0.30.30.50.4-0.6-0.7-0.70.6-0.6-0.5-0.5-0.5-0.4-0.2
Progressive ratio test 2 inactive lever presses0.00.00.10.2-0.3-0.2-0.20.1-0.2-0.1-0.2-0.1-0.00.1
Incentive Sensitization - Responses0.30.30.60.2-0.6-0.8-0.80.7-0.5-0.5-0.4-0.4-0.5-0.7
Incentive Sensitization - Breakpoint0.40.40.60.3-0.6-0.8-0.80.8-0.6-0.5-0.5-0.5-0.5-0.6
Sum of active levers in priming session hrs 5-60.00.00.0-0.0-0.0-0.1-0.1-0.00.00.10.00.00.0-0.2
Progressive ratio0.10.10.5-0.30.50.30.4-0.20.30.30.30.30.1-0.7
Food seeking constrained by brief footshock0.10.10.20.4-0.3-0.3-0.30.2-0.3-0.3-0.3-0.3-0.2-0.1
Seeking ratio, punishment vs. effort0.10.10.20.4-0.4-0.3-0.30.1-0.3-0.3-0.2-0.3-0.10.4
Retroperitoneal fat weight0.20.81.1-1.11.11.01.0-1.10.90.90.90.90.5-0.6
Reaction time number correct0.40.61.9-1.20.70.50.5-0.60.60.60.60.60.2-1.4
Reaction time mean minus median0.70.91.20.9-1.0-1.1-1.11.0-1.0-1.0-1.0-1.1-0.80.1
Reaction time mean minus median AUC0.20.32.50.1-0.00.20.2-0.20.20.10.20.10.61.6
Reaction time num false alarms0.00.10.3-0.50.20.00.0-0.10.10.20.10.20.0-0.6
Reaction time num false alarms AUC0.10.11.0-0.60.30.10.1-0.10.10.20.20.2-0.1-1.0
Reaction time trials correct on left0.40.61.9-1.20.70.50.5-0.60.60.60.60.60.2-1.4
Reaction time trials on left0.40.61.7-1.20.80.50.5-0.60.60.70.70.70.2-1.3
Reaction time mean0.10.21.40.00.10.20.2-0.30.20.00.1-0.00.41.2
Reaction time mean AUC0.10.21.4-0.10.20.30.3-0.40.20.10.20.10.51.2
Median of all reaction times0.40.61.5-0.50.60.70.7-0.80.70.60.70.50.91.2
Reaction time omissions0.20.20.40.6-0.6-0.6-0.60.5-0.4-0.4-0.4-0.4-0.20.4
Reaction time false alarm rate0.00.00.0-0.20.10.10.1-0.10.10.20.10.10.20.1
Reaction time premature initiation rate1.41.92.71.3-1.3-1.4-1.41.3-1.5-1.4-1.5-1.4-1.6-1.0
Reaction time premature initiations1.21.63.20.7-1.0-1.2-1.31.1-1.2-1.2-1.3-1.2-1.7-1.8
Std. dev. reaction times0.20.30.40.5-0.6-0.5-0.50.4-0.5-0.5-0.5-0.6-0.20.6
Reaction time trials completed0.40.61.7-1.20.80.50.5-0.60.60.70.70.70.2-1.3
Reaction time trials AUC0.40.52.4-1.10.70.40.4-0.50.50.60.60.60.0-1.6
Run reversals in cocaine runway, females0.30.30.50.6-0.7-0.6-0.50.6-0.5-0.4-0.5-0.5-0.10.7
Run reversals in cocaine runway, males1.00.91.51.2-1.1-1.0-1.00.9-1.0-1.0-1.0-1.0-0.70.6
Latency to leave start box in cocaine runway0.70.72.01.0-1.1-0.8-0.90.6-0.7-0.7-0.7-0.7-0.21.4
Latency to leave start box in cocaine runway, F0.60.64.40.0-0.10.30.2-0.50.40.40.50.41.12.1
Latency to leave start box in cocaine runway, M3.53.44.31.6-1.8-1.9-1.92.0-1.9-1.9-1.9-1.9-2.1-1.2
Std. dev. time between licks in bursts0.60.71.30.9-1.0-0.8-0.80.7-0.8-0.9-0.8-1.0-0.51.1
Total sessions with >9 infusions0.10.10.6-0.2-0.10.10.1-0.20.20.40.30.30.70.8
Short access day 1 total inactive lever presses0.00.00.10.2-0.3-0.2-0.20.2-0.2-0.1-0.1-0.0-0.0-0.1
Short access day 10 total inactive lever presses0.10.10.60.1-0.2-0.4-0.40.4-0.2-0.2-0.2-0.1-0.4-0.8
Short access day 1 total infusions0.10.10.80.4-0.4-0.1-0.1-0.0-0.2-0.0-0.2-0.10.30.9
Short access day 10 total infusions0.00.00.10.0-0.2-0.2-0.2-0.1-0.2-0.1-0.1-0.1-0.0-0.3
Short access total infusions0.00.00.1-0.0-0.10.00.0-0.20.00.20.10.10.40.4
Short access day 1 locomotion0.70.71.31.1-1.1-0.9-0.90.7-0.9-0.8-0.9-0.8-0.50.6
Short access day 10 total locomotion3.94.35.82.0-2.4-2.4-2.42.3-2.1-2.0-2.0-2.0-2.0-0.8
Short access total locomotion0.70.71.40.9-1.2-1.0-1.00.8-0.9-0.7-0.8-0.8-0.60.1
One hour access (0.3 mA shock)0.10.20.3-0.50.30.40.4-0.50.40.50.40.50.4-0.1
Compulsive drug intake1.31.31.7-1.11.11.21.2-0.91.31.31.31.31.30.7
One hour access (shock baseline)0.20.20.60.2-0.3-0.4-0.40.2-0.4-0.3-0.4-0.3-0.5-0.8
Social response proportion0.50.51.31.1-0.7-0.6-0.60.7-0.8-0.8-0.8-0.7-0.50.5
Social responses5.97.610.43.2-3.1-2.8-2.83.0-2.9-2.9-2.8-2.9-2.21.0
Social time0.50.60.9-0.81.00.90.9-0.90.80.70.80.70.5-0.3
Soleus weight8.324.428.9-5.45.35.25.2-5.15.25.25.25.24.60.0
Bone: stiffness3.14.96.0-2.22.32.32.3-2.42.32.32.32.32.30.9
Tibialis anterior weight1.13.84.9-2.22.11.91.9-1.82.12.22.12.22.00.1
Time to tail flick, vehicle, before self-admin0.40.41.80.8-0.6-0.4-0.40.6-0.4-0.4-0.4-0.30.21.3
Time to tail flick, vehicle, after self-admin0.40.41.50.3-0.2-0.4-0.40.6-0.5-0.8-0.6-0.6-1.0-1.2
Time to tail flick, test, before self-admin0.20.21.60.6-0.4-0.0-0.00.0-0.2-0.2-0.2-0.20.31.3
Time to tail flick, test, after self-admin0.10.20.50.6-0.4-0.3-0.30.2-0.3-0.5-0.3-0.3-0.10.7
Delta time to tail flick, vehicle, before/after SA0.40.42.9-0.70.60.40.4-0.30.20.10.20.1-0.4-1.7
Delta time to tail flick, test, before/after SA0.30.30.80.3-0.3-0.5-0.50.5-0.5-0.5-0.5-0.5-0.7-0.9
Tibia length1.02.83.41.7-1.7-1.7-1.71.8-1.8-1.8-1.8-1.8-1.8-0.4
Ambulatory time before self-admin0.40.40.6-0.70.60.40.4-0.50.70.80.80.80.80.2
Ambulatory time after self-admin0.30.30.60.6-0.7-0.8-0.80.7-0.5-0.4-0.5-0.5-0.30.2
Bone: tissue strength1.71.62.2-1.21.31.41.4-1.51.31.31.31.31.30.4
Total heroin consumption1.71.92.51.5-1.6-1.5-1.51.4-1.5-1.5-1.5-1.4-1.20.1
Bone: trabecular number0.40.73.31.0-0.9-0.6-0.60.7-0.5-0.5-0.5-0.50.11.8
Bone: trabecular spacing0.60.86.8-0.80.60.10.1-0.10.10.00.10.0-0.8-2.6
Bone: trabecular thickness1.51.812.90.20.10.70.7-0.70.70.70.70.81.83.6
Bone: trabecular tissue density1.31.82.7-1.51.61.41.4-1.61.31.31.31.30.8-1.1
Water consumed over 24 hours0.91.11.7-0.80.81.01.0-1.01.01.01.01.11.31.2
Number of responses in last shaping day0.10.10.30.2-0.6-0.4-0.40.3-0.4-0.2-0.3-0.2-0.10.1