Slc35b2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Slc35b2	0.04	0.02	1.2e-03	-0	0.01	0	0	5.3e-01	3.8e-02	2.9e-01	2.7e-01
2	pVTA	gene expression	Slc35b2	0.1	0.06	6.9e-03	0.08	0.02	0.03	0.05	3.1e-04	3.0e-02	2.4e-02	2.3e-03
3	Brain	gene expression	Slc35b2	0.04	0.03	7.4e-04	0.02	0.03	0.03	0.03	9.4e-03	5.1e-04	1.4e-03	1.5e-03
4	NAcc	gene expression	Slc35b2	0.05	0.03	2.2e-04	0.02	0.03	0.02	0.02	2.7e-03	3.4e-04	1.4e-03	2.5e-03
5	Liver	gene expression	Slc35b2	0.03	0.02	1.2e-03	0.01	0.02	0.01	0.01	5.1e-02	2.1e-03	1.6e-02	1.4e-02
6	LHb	gene expression	Slc35b2	0.31	0.15	9.6e-03	-0.01	0.02	0.07	0.01	7.3e-01	1.1e-01	9.1e-03	1.5e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.6	0.9	2.1	1.4	-0.4	0.9	0.9	1.3	0.0
Area under the delay curve	1.9	2.0	5.0	0.3	1.4	-2.2	-1.8	0.7	1.2
BMI with tail	2.3	7.4	17.3	-4.1	1.8	-1.5	-2.0	-4.2	0.6
BMI without tail	6.7	13.9	35.7	-5.7	2.0	-1.5	-2.4	-6.0	1.9
Body weight	0.7	3.0	8.6	-2.4	1.2	0.7	0.0	-2.9	1.2
Weight adjusted by age	0.2	0.2	0.4	0.3	0.5	-0.4	-0.5	0.3	0.7
Bone surface	1.6	2.8	7.9	2.6	-0.4	0.6	1.1	2.8	0.3
Bone volume	1.1	1.8	5.1	2.1	-0.3	0.7	0.9	2.3	0.2
Breakpoint value in progressive ratio session	0.2	0.2	0.6	0.1	0.4	-0.8	-0.7	0.3	0.2
Number of licking bursts	0.6	0.7	1.4	0.2	-1.0	1.2	1.1	-0.2	-0.6
Context. condit. distance diff. score	1.2	1.5	3.1	-1.8	0.8	-0.1	-0.5	-1.6	1.4
Locomotion velocity, session 1	1.0	1.1	1.9	-0.1	1.1	-1.3	-1.2	0.4	1.4
Locomotion distance, session 1	0.4	0.6	1.2	-1.1	0.1	-0.5	-0.7	-0.5	1.1
Locomotion velocity, session 2	2.9	3.4	6.1	-2.5	0.9	-0.9	-1.5	-2.2	2.3
Locomotion distance, session 2	0.9	1.3	2.3	-1.5	0.6	-1.1	-1.2	-1.0	1.3
Locomotion velocity, session 3	1.1	1.3	1.9	-1.4	0.2	-1.2	-1.4	-0.9	1.3
Locomotion distance, session 3	0.4	0.5	1.2	-0.5	0.6	-0.8	-0.7	-0.0	1.1
Stereotopy head waving bouts, day 3	0.2	0.2	0.5	0.5	0.0	0.7	0.7	0.3	-0.2
Stereotopy head waving duration, day 3	0.2	0.2	0.5	-0.7	0.4	-0.3	-0.4	-0.7	-0.2
Locomotion velocity, session 7	0.2	0.2	0.9	0.6	-0.2	-0.1	-0.0	1.0	0.4
Locomotion distance, session 7	0.5	0.6	1.4	-0.6	0.5	-1.2	-1.0	0.0	0.7
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	-0.4	0.7	0.3	-0.1	-0.6	0.3
Stereotopy head waving duration, day 7	0.1	0.2	0.6	0.2	0.0	0.8	0.6	-0.0	-0.1
Locomotion velocity, session 8	0.2	0.2	0.6	0.2	-0.2	0.2	0.1	0.7	0.8
Locomotion distance, session 8	1.6	2.3	4.6	-2.1	0.6	-0.8	-1.2	-1.4	2.1
Degree of sensitization distance	0.2	0.2	0.5	-0.4	0.4	-0.6	-0.7	-0.3	0.3
Degree of sensitization stereotypy	0.3	0.3	0.8	-0.3	0.9	-0.0	-0.2	-0.4	0.8
Conditioned locomotion	0.6	0.7	1.6	0.1	0.5	-1.3	-1.0	0.6	1.0
Cocaine response after cond. corrected	0.7	0.8	1.8	0.8	-1.0	0.7	0.6	0.5	-1.4
Cocaine response after cond. not corrected	0.8	0.9	2.1	1.1	-1.0	0.6	0.6	0.8	-1.4
Cocaine response before conditioning	0.3	0.3	0.9	0.7	0.0	-0.6	-0.5	0.9	0.1
Saline control response	0.1	0.2	0.3	0.1	-0.0	-0.5	-0.5	0.4	0.5
Bone: connectivity density	0.8	1.3	3.4	1.9	-0.4	0.7	0.9	1.6	-0.2
Bone: cortical apparent density	0.3	0.4	0.7	0.9	0.8	0.3	0.5	0.8	0.4
Bone: cortical area	0.2	0.3	1.4	-0.0	-0.2	0.3	0.2	0.6	1.2
Bone: cortical porosity	0.6	0.7	2.1	-1.3	0.3	-0.1	-0.3	-1.5	0.2
Bone: cortical porosity	0.5	0.6	1.5	-1.2	0.2	-0.5	-0.6	-1.2	-0.0
Bone: cortical thickness	0.7	1.1	3.9	-1.2	0.7	-0.3	-0.5	-0.7	2.0
Bone: cortical thickness	0.4	0.5	1.1	0.6	-0.5	0.9	1.0	0.7	0.3
Bone: cortical tissue density	0.3	0.4	0.7	0.8	0.8	0.3	0.5	0.8	0.3
Condit. Reinf. active minus inactive responses	0.8	0.9	1.5	0.8	-1.2	0.7	0.7	1.2	-1.1
Condit. Reinf. active-inactive response ratio	1.0	1.1	2.6	0.8	-1.1	0.9	0.9	0.8	-1.6
Condit. Reinf. active responses	0.5	0.6	2.1	0.2	-1.5	0.7	0.5	0.6	-0.5
Condit. Reinf. inactive responses	0.3	0.4	0.7	-0.8	-0.4	0.2	-0.2	-0.8	0.8
Incentive salience index mean	0.3	0.3	1.4	-0.1	-1.2	0.4	0.2	0.4	-0.4
Condit. Reinf. lever presses	0.4	0.6	1.5	-1.2	-0.5	-0.1	-0.5	-1.0	0.7
Condit. Reinf. active minus inactive responses	0.1	0.2	0.6	0.3	0.0	-0.2	-0.0	0.7	-0.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	0.3	-0.1	0.3	0.3	0.6	-0.8
Condit. Reinf. active responses	0.3	0.4	1.0	0.2	0.5	-1.0	-0.7	0.8	0.4
Condit. Reinf. inactive responses	0.7	0.8	1.7	0.1	0.9	-1.2	-0.8	0.4	1.3
Condit. Reinf. lever presses	0.2	0.3	0.8	-0.5	0.9	-0.5	-0.3	-0.2	0.6
Condit. Reinf. lever reinforcers received	0.2	0.3	0.8	0.1	0.4	-0.9	-0.6	0.7	0.5
Conditioned reinforcement - actives	0.4	0.4	1.6	-0.5	0.0	-0.9	-1.2	-0.0	0.3
Conditioned reinforcement - inactives	0.3	0.3	0.8	-0.6	0.4	-0.6	-0.9	-0.5	-0.1
Conditioned locomotion	0.0	0.0	0.1	-0.1	-0.0	0.3	0.1	-0.1	0.3
Patch foraging indifference point 0 sec	0.8	1.3	4.2	-0.7	2.0	-0.9	-0.9	-0.9	0.8
Patch foraging indifference point AUC	2.6	2.9	5.4	-1.6	1.6	-2.3	-2.3	-0.8	1.1
Delay disc. indifference point, 0s delay	1.6	1.8	3.3	0.5	1.6	-1.8	-1.3	1.2	-1.2
Delay disc. indifference point, 16s delay	0.7	0.7	1.6	0.9	0.7	-1.2	-0.8	0.8	0.3
Delay disc. indifference point, 2s delay	1.2	1.3	4.1	-0.0	0.8	-2.0	-1.7	0.4	-0.3
Delay disc. indifference point, 24s delay	1.5	1.4	4.1	-0.5	1.2	-1.0	-1.1	-0.6	2.0
Delay disc. indifference point, 4s delay	2.4	2.5	6.7	-0.7	1.7	-2.6	-2.2	-0.1	0.4
Delay disc. indifference point, 8s delay	1.3	1.3	2.7	0.7	0.7	-1.6	-1.3	1.2	1.1
Indifference point function ln k	0.2	0.3	0.6	-0.0	0.4	0.5	0.5	-0.7	-0.8
Indifference point function log k	0.2	0.3	0.6	-0.0	0.4	0.5	0.5	-0.7	-0.8
Patch foraging total patch changes 0 sec	1.1	1.7	5.6	-0.9	2.4	-1.1	-1.0	-1.0	0.9
Patch foraging total patch changes 12 sec	3.0	3.9	6.3	-1.8	2.5	-1.7	-1.8	-1.4	2.4
Patch foraging total patch changes 18 sec	0.6	0.8	1.5	-0.2	1.2	-1.1	-1.0	0.1	1.0
Patch foraging total patch changes 24 sec	2.9	3.5	7.0	-1.6	2.7	-1.7	-1.6	-1.2	2.1
Patch foraging total patch changes 6 sec	2.0	3.0	5.6	-1.7	2.4	-1.5	-1.6	-1.5	1.6
Patch foraging time to switch 0 sec	3.2	4.9	7.8	2.8	-2.3	2.2	2.4	2.3	-0.6
Patch foraging water rate 0 sec	3.4	5.5	10.1	-2.3	3.2	-2.5	-2.6	-1.5	1.7
Patch foraging water rate 12 sec	3.2	4.9	10.1	-3.2	2.3	-1.5	-2.0	-2.6	1.1
Patch foraging water rate 18 sec	1.5	2.0	3.7	-1.7	1.9	-1.0	-1.0	-1.7	0.8
Patch foraging water rate 24 sec	1.8	2.5	5.4	-2.3	1.8	-0.7	-0.8	-2.3	-0.3
Patch foraging water rate 6 sec	0.9	1.3	2.8	-1.2	1.7	-1.2	-1.3	-0.6	0.5
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.0	0.2	0.1	0.0	0.0	0.0
Distance traveled before self-admin	0.3	0.3	0.6	-0.8	-0.1	0.5	0.5	-0.8	0.5
Distance traveled after self-admin	0.2	0.3	0.5	-0.7	-0.1	-0.1	-0.5	-0.7	-0.5
Extensor digitorum longus weight	0.1	0.2	0.5	-0.7	0.1	0.5	0.4	-0.6	-0.1
Bone: elastic displacement	0.3	0.3	0.8	0.1	-0.7	0.9	0.8	-0.2	0.2
Bone: elastic work	1.5	2.0	4.5	0.1	-1.9	2.1	2.0	-0.3	0.0
Bone: endosteal estimation	1.3	2.9	4.7	2.2	-1.3	1.2	1.6	2.2	-1.5
Bone: endosteal perimeter	1.0	2.1	4.5	1.9	-1.4	1.0	1.1	2.1	-0.8
Epididymis fat weight	0.9	2.1	5.5	-1.6	1.1	1.1	0.5	-2.3	1.3
Delta time in closed arm before/after self-admin	0.5	0.5	0.9	-0.7	1.0	-0.3	-0.3	-0.9	0.6
Delta time in open arm before/after self-admin	1.0	0.9	2.7	-0.5	0.2	-1.7	-1.6	-0.2	-0.2
Diff in mean of infusions in LGA sessions	0.4	0.5	1.6	0.4	-0.5	0.6	0.5	0.3	-1.3
Delay discount exponential model param	2.2	2.3	5.0	-0.2	-1.4	2.2	1.9	-0.6	-1.6
Extinction: sum of active levers before priming	0.2	0.2	0.6	0.5	-0.3	-0.1	0.1	0.8	0.1
Active lever presses in extinction session 6	0.3	0.3	0.5	-0.6	0.2	-0.3	-0.7	-0.6	0.7
Bone: final force	0.2	0.4	1.0	-0.2	-0.0	0.8	0.8	0.2	1.0
Bone: final moment	0.2	0.3	1.2	-0.3	0.3	0.4	0.5	0.2	1.1
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.2	0.5	-0.3	-0.3	-0.2	0.0
Glucose	1.2	1.7	4.2	-2.0	1.2	-0.4	-0.7	-2.0	0.6
Heart weight	0.9	1.3	3.3	1.8	0.5	0.4	1.0	1.7	0.2
Delay discount hyperbolic model param	2.2	2.3	5.6	-0.2	-1.4	2.4	2.0	-0.6	-1.4
Intermittent access intake day 1-15 change	0.4	0.4	0.7	0.5	-0.8	0.5	0.4	0.4	-0.9
Intermittent access intake escalation	1.2	1.1	1.4	1.2	-1.2	1.0	1.0	0.9	-1.1
Intermittent access intake escalation 2	0.2	0.2	0.6	0.3	0.2	-0.1	-0.1	0.4	0.7
Intermitt. access day 1 inactive lever presses	2.0	2.1	4.7	0.4	-2.2	1.7	1.5	0.1	-1.7
Intermitt. access day 15 inactive lever presses	0.3	0.3	1.6	-0.1	-0.0	0.1	0.3	-0.3	-1.3
Intermitt. access escalation Index	0.7	0.6	1.3	-1.2	0.5	-0.4	-0.4	-1.2	-0.7
Intermittent access day 1 total infusions	0.2	0.2	0.7	-0.4	-0.1	0.3	-0.2	-0.8	0.5
Intermittent access day 15 total infusions	0.6	0.7	1.5	0.7	-1.2	1.2	0.8	0.1	-0.6
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.5	0.2	-0.7	0.7	0.3	-0.2	0.1
Intermittent access total infusions	0.1	0.1	0.3	-0.1	-0.4	0.0	-0.4	-0.5	-0.0
Intermittent access day 1 locomotion	0.2	0.2	0.5	-0.3	-0.3	0.6	0.3	-0.7	-0.1
Intermittent access day 15 total locomotion	0.3	0.3	0.5	0.6	-0.7	0.5	0.4	0.4	0.5
Intermittent access total locomotion	0.2	0.2	0.5	0.7	-0.5	0.1	0.2	0.5	0.1
Intermittent access standard deviation	0.5	0.6	1.3	1.2	-0.5	0.7	0.6	0.8	0.6
Left kidney weight	0.6	1.8	3.8	-1.1	2.0	-0.9	-1.1	-1.1	1.5
Right kidney weight	1.1	3.1	9.1	-1.1	3.0	-1.7	-1.7	-0.9	1.5
Cocaine induced anxiety	1.0	1.1	3.9	0.5	-1.4	0.5	0.5	0.2	-2.0
Post-drug Anxiety	4.1	4.6	6.3	2.2	-2.2	2.3	2.5	1.7	-1.9
Baseline Anxiety	2.5	2.6	4.1	2.0	-0.8	1.7	2.0	1.8	0.8
Tail length	0.8	2.4	5.5	-1.9	0.5	0.6	-0.1	-2.3	2.2
Length with tail	0.7	2.5	5.6	1.4	-0.0	2.4	2.1	0.8	1.6
Length without tail	3.1	6.8	12.9	3.6	-1.2	2.6	2.9	3.3	-0.7
Times rat made contact with spout	0.2	0.3	0.8	-0.6	0.5	-0.2	-0.3	-0.9	0.3
Lifetime Intake	0.0	0.0	0.1	0.2	-0.2	-0.0	-0.3	-0.1	-0.2
Liver weight, left	0.6	1.0	1.8	-1.3	0.6	-0.8	-0.9	-0.9	1.3
Liver weight, right	0.9	1.5	4.6	-0.5	-2.1	1.6	1.1	-0.5	-0.6
Locomotor activity	0.8	1.2	3.8	-0.1	-0.4	2.0	1.6	-0.6	0.6
Locomotor testing distance	0.7	1.2	3.3	-0.1	0.1	1.8	1.6	-0.4	1.2
Locomotor testing rearing	0.4	0.6	1.7	-1.3	-0.3	0.7	0.4	-1.1	0.3
Locomotion in novel chamber	1.7	2.1	4.0	-1.3	1.2	-1.9	-2.0	-0.8	1.2
Locomotion in novel chamber post-restriction	0.8	1.0	1.8	1.0	0.2	-1.2	-1.3	1.3	0.4
Fecal boli incidents, locomotor time 1	0.4	0.5	0.9	-0.5	0.4	-0.9	-0.8	0.1	1.0
Change in fecal boli incidents, locomotor task	0.4	0.4	1.3	0.7	-0.1	-0.3	-0.4	0.4	-1.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	-0.3	0.6	-0.6	-0.5	-0.1	-0.2
Bouts of movement, locomotor time 1	1.1	1.2	1.9	-1.0	1.4	-1.1	-1.2	-0.8	0.8
Total resting periods, locomotor time 1	0.5	0.6	1.4	-0.7	1.2	-0.7	-0.8	-0.6	0.3
Rest time, locomotor task time 1	1.4	1.5	3.4	-0.4	1.6	-1.8	-1.7	0.1	-0.5
Distance moved, locomotor task time 1	0.3	0.3	0.8	-0.8	-0.5	0.4	0.2	-0.9	0.1
Vertical activity count, locomotor time 1	0.6	0.6	1.8	-0.2	-1.3	1.0	0.7	-0.6	0.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	0.1	-0.2	0.2	0.4	0.0	-0.6
Bouts of movement, locomotor time 2	1.3	1.5	3.0	-1.0	1.3	-0.9	-1.1	-0.9	1.7
Total resting periods, locomotor time 2	0.9	1.0	1.6	-0.9	1.2	-0.7	-0.9	-0.9	1.3
Rest time, locomotor task time 2	0.6	0.6	1.8	-0.0	1.4	-1.1	-0.9	0.2	-0.0
Distance moved, locomotor task time 2	0.2	0.2	0.7	-0.1	-0.8	0.3	0.3	-0.1	-0.8
Vertical activity count, locomotor time 2	0.9	1.0	2.1	1.0	-1.5	0.8	0.9	1.0	-0.7
Light reinforcement 1	0.2	0.4	0.8	-0.9	0.1	-0.0	-0.4	-0.8	0.8
Light reinforcement 2	0.2	0.3	0.7	-0.3	-0.7	0.8	0.6	-0.5	-0.5
Bone: marrow area	1.4	2.9	4.9	2.2	-1.4	1.2	1.7	2.2	-1.3
Bone: maximum diameter	0.3	0.5	2.0	0.8	-0.1	-0.3	-0.2	1.4	0.2
Bone: maximum force	0.6	1.0	2.4	0.3	-1.0	1.5	1.6	0.4	0.2
Bone: maximum moment	0.3	0.6	1.6	0.1	-0.6	1.2	1.3	0.3	0.2
Mean time between licks in bursts	0.8	1.2	2.7	1.6	-0.4	0.5	0.9	1.4	-1.0
Mean num. licks in bursts	1.0	1.1	2.3	-0.5	1.5	-1.4	-1.4	-0.3	0.6
Cd content in liver	0.7	0.8	1.5	0.9	-0.9	-0.3	-0.1	1.1	-1.2
Co content in liver	0.8	1.0	2.0	-0.9	-1.3	-0.1	-0.3	-1.1	-1.4
Cu content in liver	0.1	0.1	0.3	0.3	-0.2	-0.5	-0.4	0.6	0.1
Fe content in liver	0.7	0.9	3.3	-0.8	0.4	-0.5	-0.7	-0.6	1.8
K content in liver	2.3	2.3	4.6	1.4	-1.5	2.1	2.1	0.8	-0.2
Mg content in liver	0.3	0.4	1.5	0.4	0.1	0.4	0.5	0.3	1.2
Mn content in liver	0.3	0.3	1.4	0.4	0.6	-0.3	-0.1	0.1	-1.2
Na content in liver	0.3	0.4	1.3	-0.6	0.2	0.2	0.0	-0.6	1.1
Rb content in liver	1.5	1.9	4.5	2.1	-1.1	0.7	1.0	2.0	0.4
Se content in liver	2.2	2.8	6.5	-0.5	2.6	-1.9	-1.7	-0.1	1.7
Sr content in liver	0.6	0.6	2.2	-0.0	-1.0	0.4	0.4	0.0	-1.5
Zn content in liver	1.4	1.6	2.6	0.5	1.5	-1.6	-1.3	1.1	1.2
Bone: minimum diameter	0.8	1.5	3.4	1.6	-1.0	1.0	1.2	1.9	-0.1
Time in familiar zone, hab. session 1	3.2	3.0	4.5	-2.1	1.3	-1.3	-1.7	-2.1	1.5
Time in novel zone, hab. session 1	2.2	2.1	4.2	1.7	-0.8	0.7	1.2	1.8	-2.0
Total zone transitions, hab. session 1	0.7	1.0	3.3	-1.8	0.2	-0.5	-0.7	-1.4	0.5
Total locomotion distance, hab. session 1	0.7	1.1	3.4	-1.8	0.3	-0.4	-0.8	-1.4	0.6
Locomotion velocity, hab. session 1	0.5	0.7	2.6	-1.6	-0.2	-0.1	-0.5	-1.1	0.6
Time in familiar zone, hab. session 2	0.4	0.4	1.0	0.6	-0.7	1.0	0.8	-0.1	-0.1
Time in novel zone, hab. session 2	1.1	1.1	1.9	-1.1	1.3	-1.4	-1.2	-0.4	0.1
Total zone transitions, hab. session 2	0.2	0.3	0.8	-0.0	-0.4	0.9	0.8	-0.0	-0.4
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.4	-0.1	0.4	0.2	-0.5	-0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.0	-0.2	0.6	0.4	-0.1	-0.3
Novel to familiar place preference ratio	0.0	0.0	0.1	0.0	-0.2	0.2	0.2	-0.1	-0.3
Novelty place preference	0.1	0.1	0.1	-0.1	-0.1	0.4	0.3	-0.2	0.2
Time in novel zone, NPP test	0.1	0.1	0.1	-0.3	0.3	-0.0	-0.0	-0.4	0.2
Total zone transitions, NPP test	0.6	0.8	1.9	-1.3	0.5	-0.2	-0.4	-1.0	1.4
Total locomotion distance, NPP test	0.4	0.5	1.5	-1.2	0.2	0.0	-0.3	-0.9	0.8
Locomotion velocity, NPP test	0.4	0.6	0.9	-0.8	-0.5	1.0	0.6	-0.6	1.0
Intraocular pressure	1.5	2.1	8.8	0.5	-1.7	0.5	0.6	0.2	-3.0
Delta distance traveled before/after self-admin	0.3	0.3	1.6	-0.0	-0.1	-0.1	-0.6	-0.2	-1.3
Delta ambulatory time before/after self-admin	0.6	0.7	3.1	0.5	-0.7	0.4	-0.1	0.2	-1.8
Parametrial fat weight	2.0	3.8	10.3	-3.1	1.4	-0.1	-0.7	-3.2	0.8
Pavlov. Cond. lever latency	1.0	1.3	3.0	1.3	-0.6	0.8	1.1	0.9	-1.7
Pavlov. Cond. magazine entry latency	0.4	0.5	1.2	-0.6	0.7	-1.1	-1.1	-0.2	0.3
Pavlov. Cond. change in total contacts	0.5	0.6	1.0	-1.0	0.3	-0.8	-1.0	-0.7	0.4
Pavlov. Cond. index score	0.7	0.9	1.4	-1.1	0.5	-0.9	-1.2	-0.6	1.1
Pavlov. Cond. latency score	0.7	0.9	1.9	-1.0	0.5	-0.9	-1.1	-0.4	1.4
Pavlov. Cond. lever contacts	0.9	1.1	2.0	-1.4	0.3	-0.5	-0.9	-1.2	1.4
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	0.7	-0.2	0.8	1.0	0.3	-0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.4	0.0	0.0	-0.0	-0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.4	-1.1	0.3	-0.9	-1.2	-0.6	0.7
Pavlov. Cond. response bias	0.7	0.8	1.7	-1.3	0.5	-0.7	-1.0	-1.1	0.7
Pavlov. Cond. lever latency	0.1	0.2	0.4	0.1	0.4	-0.6	-0.6	-0.1	-0.2
Pavlov. Cond. magazine entry latency	0.4	0.4	1.1	-1.0	-0.3	0.4	0.3	-0.6	1.0
Pavlov. Cond. change in total contacts	0.2	0.3	0.7	-0.7	0.1	0.6	0.5	-0.5	0.9
Pavlov. Cond. index score	0.5	0.6	1.4	-1.2	0.2	0.4	0.2	-0.8	1.2
Pavlov. Cond. latency score	0.5	0.6	1.6	-1.3	0.2	0.3	0.2	-0.9	1.1
Pavlov. Cond. lever contacts	0.2	0.3	0.8	-0.3	-0.1	0.7	0.7	-0.1	0.9
Pavlov. Cond. magazine entry number	0.4	0.5	2.0	0.7	0.2	-0.6	-0.5	0.3	-1.4
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.0	1.0	0.1	0.1	0.1	0.4	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.5	-1.2	0.1	0.4	0.2	-0.9	1.2
Pavlov. Cond. response bias	0.4	0.6	1.8	0.2	-0.1	0.8	0.9	0.5	1.4
Time in closed arm before self-admin	1.4	1.6	3.1	1.1	-1.1	1.2	1.4	0.8	-1.8
Time in closed arm after self-admin	0.9	0.9	3.9	-0.5	-0.3	0.6	0.7	-0.8	-2.0
Time in open arm before self-admin	0.7	0.7	2.6	-0.9	0.2	-0.1	-0.5	-0.8	1.6
Time in open arm after self-admin	0.7	0.7	1.7	-0.9	-0.1	-1.1	-1.3	-0.5	0.7
Bone: periosteal estimation	0.6	1.2	3.0	1.3	-0.9	0.7	0.9	1.7	-0.3
Bone: periosteal perimeter	0.7	1.2	1.8	0.8	-1.4	1.3	1.2	1.1	0.2
Bone: post-yield work	0.3	0.4	1.1	0.0	-0.5	1.0	1.0	-0.1	-0.6
Progressive ratio test 1 active lever presses	1.7	1.8	3.9	0.1	-2.0	1.5	1.1	-0.5	-1.7
Progressive ratio test 1 breakpoint	2.1	2.1	4.9	0.3	-2.2	1.6	1.2	-0.3	-1.9
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.8	-0.2	-0.4	0.9	0.7	-0.5	-0.6
Progressive ratio test 2 active lever presses	0.5	0.6	1.3	-0.6	-0.9	0.4	-0.2	-0.9	-1.1
Progressive ratio test 2 breakpoint	0.6	0.6	1.3	-0.8	-0.8	0.2	-0.3	-1.2	-1.0
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.4	-0.8	0.5	-0.8	-1.2	-0.9	0.2
Incentive Sensitization - Responses	1.6	1.6	3.1	-1.7	0.8	-1.0	-1.4	-1.7	-0.1
Incentive Sensitization - Breakpoint	1.5	1.5	2.6	-1.6	0.9	-1.0	-1.4	-1.6	0.1
Sum of active levers in priming session hrs 5-6	2.2	2.1	3.5	1.5	1.1	-1.6	-1.4	1.9	1.2
Progressive ratio	2.2	2.6	4.7	1.8	-0.4	1.8	2.2	1.6	1.2
Food seeking constrained by brief footshock	2.3	2.8	3.8	1.8	-1.8	1.9	1.9	1.5	-0.7
Seeking ratio, punishment vs. effort	0.4	0.5	1.3	-0.5	-0.7	-0.4	-0.8	-0.4	-1.1
Retroperitoneal fat weight	0.8	2.6	5.6	-2.4	1.6	-0.5	-0.8	-2.2	1.4
Reaction time number correct	3.4	5.0	11.7	-1.1	3.4	-2.8	-2.6	-0.2	1.5
Reaction time mean minus median	1.2	1.6	3.0	1.0	-1.4	1.5	1.7	0.9	-0.7
Reaction time mean minus median AUC	1.9	2.4	3.9	1.5	-1.5	1.7	2.0	1.3	-1.3
Reaction time num false alarms	1.0	1.3	2.8	-0.3	1.7	-1.3	-1.2	-0.2	1.3
Reaction time num false alarms AUC	1.1	1.5	3.0	-0.6	1.7	-1.4	-1.3	-0.5	1.3
Reaction time trials correct on left	3.4	5.0	11.7	-1.1	3.4	-2.8	-2.6	-0.2	1.5
Reaction time trials on left	3.5	4.9	11.7	-1.1	3.4	-2.8	-2.5	-0.3	1.5
Reaction time mean	2.6	3.6	6.8	0.8	-2.5	2.6	2.5	0.0	-1.4
Reaction time mean AUC	2.5	3.4	6.6	0.9	-2.3	2.6	2.5	0.2	-1.4
Median of all reaction times	2.3	3.2	6.3	0.4	-2.4	2.5	2.2	-0.4	-1.2
Reaction time omissions	0.2	0.3	0.6	-0.5	-0.3	0.6	0.3	-0.8	0.6
Reaction time false alarm rate	0.0	0.0	0.1	0.1	-0.2	0.1	0.1	-0.1	0.3
Reaction time premature initiation rate	0.1	0.2	0.4	-0.5	0.4	-0.1	0.2	-0.4	0.6
Reaction time premature initiations	1.2	1.7	4.4	-1.0	2.1	-1.3	-1.0	-0.5	1.4
Std. dev. reaction times	2.1	2.9	5.6	0.9	-2.1	2.4	2.4	0.3	-1.0
Reaction time trials completed	3.5	4.9	11.7	-1.1	3.4	-2.8	-2.5	-0.3	1.5
Reaction time trials AUC	3.4	4.9	11.6	-1.2	3.4	-2.8	-2.5	-0.4	1.5
Run reversals in cocaine runway, females	0.7	0.7	1.0	0.8	-0.7	1.0	0.9	0.8	-0.5
Run reversals in cocaine runway, males	0.7	0.7	2.4	-0.7	1.5	-0.8	-0.5	-0.6	-0.2
Latency to leave start box in cocaine runway	2.2	2.4	4.3	-0.3	-1.8	1.9	1.7	-0.6	-2.1
Latency to leave start box in cocaine runway, F	1.6	1.8	2.8	0.3	-1.5	1.6	1.7	0.2	-1.6
Latency to leave start box in cocaine runway, M	1.1	1.0	2.3	-1.4	-0.7	0.7	0.4	-1.5	-0.8
Std. dev. time between licks in bursts	0.5	0.6	1.0	0.8	-0.8	-0.1	0.1	1.0	-1.0
Total sessions with >9 infusions	0.2	0.2	0.6	-0.4	0.8	-0.2	-0.1	-0.4	0.2
Short access day 1 total inactive lever presses	0.7	0.8	1.7	-0.9	1.3	-1.0	-1.0	-0.6	0.2
Short access day 10 total inactive lever presses	0.4	0.5	0.9	-0.8	0.9	-0.7	-0.5	-0.5	0.6
Short access day 1 total infusions	0.4	0.4	0.7	-0.8	0.5	-0.8	-0.8	-0.6	-0.4
Short access day 10 total infusions	0.1	0.1	0.3	0.4	-0.5	0.5	0.2	-0.1	-0.1
Short access total infusions	0.0	0.0	0.1	0.2	0.1	-0.0	-0.0	0.1	-0.2
Short access day 1 locomotion	0.2	0.2	0.4	0.3	-0.5	0.3	0.6	0.6	-0.4
Short access day 10 total locomotion	0.4	0.4	0.8	0.9	-0.4	0.4	0.4	0.8	0.6
Short access total locomotion	0.2	0.2	0.6	0.6	-0.1	-0.1	0.2	0.8	0.4
One hour access (0.3 mA shock)	0.4	0.5	1.9	-0.3	-0.2	-1.0	-1.4	-0.0	0.1
Compulsive drug intake	0.2	0.2	0.8	0.2	0.2	-0.4	-0.1	0.5	-0.9
One hour access (shock baseline)	0.2	0.2	0.5	-0.4	-0.7	0.2	-0.5	-0.7	0.0
Social response proportion	0.3	0.3	0.6	0.7	-0.8	0.4	0.3	0.5	0.6
Social responses	0.6	0.8	1.8	0.5	-1.1	0.8	0.7	0.4	1.3
Social time	2.2	2.9	5.2	-1.6	1.1	-2.3	-2.3	-0.7	1.8
Soleus weight	0.1	0.4	0.8	-0.9	-0.9	0.7	0.4	-0.6	0.3
Bone: stiffness	0.0	0.1	0.3	-0.1	0.1	0.3	0.3	0.0	0.5
Tibialis anterior weight	0.3	0.9	2.2	-1.5	0.9	-0.5	-0.7	-1.1	0.4
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.8	-0.0	0.7	0.2	0.2	0.1	1.3
Time to tail flick, vehicle, after self-admin	1.1	1.2	2.1	1.4	-1.2	0.9	1.0	1.3	-0.3
Time to tail flick, test, before self-admin	1.9	1.8	4.8	0.5	0.1	-2.2	-1.7	1.3	-1.1
Time to tail flick, test, after self-admin	0.2	0.2	0.4	-0.6	-0.6	-0.1	-0.1	-0.0	-0.6
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.0	0.8	-1.0	0.1	0.1	0.8	-0.6
Delta time to tail flick, test, before/after SA	1.5	1.3	2.4	-1.3	-0.6	1.5	1.0	-1.5	0.4
Tibia length	0.7	2.0	3.8	-1.7	1.2	-1.7	-1.9	-0.9	0.5
Ambulatory time before self-admin	0.9	0.9	2.3	-1.5	0.7	-0.4	-0.3	-1.4	0.8
Ambulatory time after self-admin	0.3	0.4	1.0	-1.0	0.1	0.1	-0.3	-0.9	-0.4
Bone: tissue strength	0.7	0.7	1.3	-0.8	1.0	-0.5	-0.5	-0.8	1.1
Total heroin consumption	0.2	0.3	1.4	-0.1	0.3	0.1	-0.2	-0.2	1.2
Bone: trabecular number	0.6	0.9	2.2	1.4	0.3	0.4	0.5	1.5	0.9
Bone: trabecular spacing	1.6	2.1	2.9	-1.7	1.3	-1.4	-1.5	-1.6	1.0
Bone: trabecular thickness	2.2	2.7	6.8	2.5	-0.5	0.9	1.2	2.6	-0.7
Bone: trabecular tissue density	3.3	4.7	10.2	-1.7	2.4	-3.2	-2.9	-0.6	0.3
Water consumed over 24 hours	1.9	2.3	3.8	-1.3	1.8	-1.1	-1.4	-1.3	1.9
Number of responses in last shaping day	0.8	0.8	1.5	-1.2	0.1	-0.6	-0.9	-1.1	-0.9