Hub : Genes

Slc35b2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Slc35b2	0.08	0.04	1.3e-06	0.08	0.06	0.07	0.08	4.3e-07	7.5e-06	3.3e-06	9.8e-07
2	PL	gene expression	Slc35b2	0.03	0.02	2.1e-03	-0	0.01	0	-0	7.7e-01	3.9e-02	3.6e-01	6.6e-01
3	Liver	gene expression	Slc35b2	0.03	0.02	6.5e-04	0.03	0.03	0.02	0.02	3.8e-04	7.1e-04	2.1e-03	1.6e-03
4	Brain	gene expression	Slc35b2	0.04	0.03	1.0e-03	0.02	0.03	0.03	0.03	3.0e-03	9.1e-04	1.3e-03	8.2e-04
5	NAcc	gene expression	Slc35b2	0.05	0.03	4.1e-06	0.02	0.03	0.03	0.01	2.6e-04	8.9e-06	1.9e-05	8.6e-03
6	NAcc	alternative TSS	NM_001037215.3	0.04	0.03	3.9e-03	0.01	0.01	0.02	0.02	2.2e-02	6.1e-03	2.1e-04	6.6e-04
7	LHb	gene expression	Slc35b2	0.32	0.16	9.7e-03	-0	-0	0.04	0.01	3.7e-01	4.2e-01	4.3e-02	2.0e-01
8	NAcc	alternative TSS	XM_063267580.1	0.05	0.04	1.1e-03	0	0.01	0.02	0.02	6.4e-02	3.0e-03	2.6e-04	4.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bone: apparent density	0.8	1.4	3.8	0.5	1.9	1.5	1.1	1.5	-1.0	0.3	0.8
Area under the delay curve	2.2	2.6	9.1	-3.0	-0.1	1.2	-2.1	-2.1	-0.7	-0.9	-0.1
BMI with tail	1.6	5.6	13.5	0.3	-3.7	-3.5	-1.8	-2.0	2.5	-0.6	-2.3
BMI without tail	2.1	6.3	18.1	1.5	-3.2	-4.3	-1.0	-1.0	3.1	-0.9	-2.8
Body weight	1.2	5.1	11.3	2.7	-1.5	-3.1	0.5	0.9	3.4	-0.5	-2.9
Weight adjusted by age	0.1	0.2	0.7	-0.3	0.1	0.8	-0.3	-0.2	-0.5	0.4	0.6
Bone surface	1.8	3.2	8.6	-0.4	2.9	2.7	0.8	1.7	-2.0	0.2	1.5
Bone volume	1.4	2.6	6.7	-0.0	2.6	2.3	1.0	1.6	-1.7	0.4	1.4
Breakpoint value in progressive ratio session	0.7	0.8	2.0	-0.7	0.4	1.3	-0.4	-0.4	-1.4	0.7	1.1
Number of licking bursts	0.4	0.7	2.1	1.4	0.4	-0.3	1.1	1.1	0.7	0.3	-0.3
Context. condit. distance diff. score	1.1	1.4	2.8	0.8	-1.5	-1.7	-0.4	-0.1	1.6	-1.1	-1.3
Locomotion velocity, session 1	0.9	1.0	2.8	-1.7	-0.2	1.0	-1.2	-0.9	-0.3	-1.3	-0.1
Locomotion distance, session 1	0.3	0.4	1.4	-0.5	-1.0	0.0	-0.6	-0.5	-0.2	-1.2	0.2
Locomotion velocity, session 2	2.5	2.9	5.6	-0.4	-2.4	-1.6	-1.0	-1.3	1.8	-2.3	-1.7
Locomotion distance, session 2	0.7	0.9	2.2	-0.8	-1.5	-0.5	-1.0	-1.1	0.1	-1.3	-0.1
Locomotion velocity, session 3	1.1	1.2	2.4	-1.2	-1.5	-0.6	-1.1	-1.5	0.5	-1.0	-0.8
Locomotion distance, session 3	0.4	0.4	0.8	-0.9	-0.7	-0.2	-0.9	-0.7	0.0	-0.8	-0.2
Stereotopy head waving bouts, day 3	0.2	0.2	0.8	0.6	0.6	0.0	0.4	0.9	-0.2	0.0	0.3
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.0	-0.5	-0.2	-0.3	-0.3	-0.1	0.1	0.3
Locomotion velocity, session 7	0.5	0.5	1.2	-0.8	0.5	0.9	-0.0	0.1	-1.1	-0.3	1.0
Locomotion distance, session 7	0.6	0.7	1.7	-1.3	-0.8	0.2	-0.8	-1.0	-1.0	-0.0	0.9
Stereotopy head waving bouts, day 7	0.3	0.4	1.1	0.7	-0.2	-1.0	-0.1	0.5	0.7	-0.6	-0.4
Stereotopy head waving duration, day 7	0.2	0.2	0.6	0.8	0.3	-0.5	0.4	0.8	0.4	-0.3	-0.0
Locomotion velocity, session 8	0.1	0.1	0.1	-0.3	0.3	0.4	0.2	0.4	-0.3	-0.4	0.3
Locomotion distance, session 8	1.0	1.4	4.1	-0.3	-2.0	-1.3	-0.9	-0.8	0.9	-1.7	-0.8
Degree of sensitization distance	0.2	0.2	0.4	-0.6	-0.5	0.1	-0.4	-0.6	-0.5	0.0	0.5
Degree of sensitization stereotypy	0.3	0.3	0.9	-0.1	-0.3	-0.7	-0.6	-0.0	0.5	-1.0	-0.2
Conditioned locomotion	0.8	0.9	2.9	-1.7	0.1	0.9	-1.2	-1.0	-0.9	-0.4	0.3
Cocaine response after cond. corrected	0.8	1.0	2.9	0.5	0.8	0.8	1.1	0.4	-1.0	1.7	1.0
Cocaine response after cond. not corrected	1.0	1.2	3.0	0.0	1.0	1.3	1.0	0.4	-1.2	1.7	1.2
Cocaine response before conditioning	0.6	0.7	1.8	-1.3	0.5	1.1	-0.8	-0.4	-0.9	-0.3	0.7
Saline control response	0.2	0.3	1.3	-1.1	0.2	0.6	-0.2	-0.6	0.0	0.3	-0.3
Bone: connectivity density	1.0	1.5	4.4	0.1	2.1	1.9	0.8	1.3	-1.1	0.1	0.8
Bone: cortical apparent density	0.2	0.3	0.9	0.1	0.9	0.6	0.0	0.9	0.1	-0.3	0.0
Bone: cortical area	0.3	0.4	1.6	0.4	0.2	0.3	0.4	0.8	-0.4	-1.3	0.5
Bone: cortical porosity	0.6	0.7	1.6	0.3	-1.0	-1.3	-0.2	-0.5	1.1	-0.3	-1.1
Bone: cortical porosity	0.6	0.6	1.7	0.2	-1.2	-1.3	-0.3	-0.8	0.7	0.0	-0.7
Bone: cortical thickness	0.5	0.9	5.2	0.4	-0.8	-0.7	-0.3	0.2	0.5	-2.3	-0.4
Bone: cortical thickness	0.3	0.4	1.4	0.6	0.8	0.1	0.7	1.2	-0.2	-0.5	0.2
Bone: cortical tissue density	0.2	0.3	0.9	0.1	1.0	0.7	0.0	0.9	0.0	-0.1	0.1
Condit. Reinf. active minus inactive responses	1.1	1.2	3.2	0.1	0.7	1.4	0.7	0.8	-1.5	0.8	1.8
Condit. Reinf. active-inactive response ratio	1.0	1.1	3.1	0.6	0.7	0.9	0.9	0.9	-0.9	1.8	1.3
Condit. Reinf. active responses	0.5	0.6	1.5	0.2	0.3	1.0	0.8	0.6	-1.0	0.4	1.2
Condit. Reinf. inactive responses	0.2	0.3	1.0	0.1	-0.6	-0.5	0.1	-0.4	0.5	-1.0	-0.6
Incentive salience index mean	0.3	0.3	0.9	0.0	-0.1	0.8	0.5	0.3	-0.8	0.2	1.0
Condit. Reinf. lever presses	0.3	0.4	1.5	0.0	-1.2	-0.6	-0.1	-0.7	0.7	-0.6	-0.6
Condit. Reinf. active minus inactive responses	0.7	1.0	3.3	-0.2	-0.0	0.8	0.1	0.0	-1.7	0.9	1.8
Condit. Reinf. active-inactive response ratio	0.8	0.9	3.0	0.5	0.1	0.9	0.5	0.5	-1.5	0.9	1.7
Condit. Reinf. active responses	0.6	0.9	2.1	-1.2	-0.2	0.7	-0.6	-0.6	-1.5	0.4	1.3
Condit. Reinf. inactive responses	0.5	0.7	2.9	-1.7	-0.0	0.1	-1.1	-0.9	-0.1	-0.5	-0.3
Condit. Reinf. lever presses	0.2	0.2	0.5	-0.4	-0.7	-0.2	-0.5	-0.4	-0.5	-0.0	0.5
Condit. Reinf. lever reinforcers received	0.5	0.7	1.9	-1.1	-0.3	0.6	-0.5	-0.6	-1.4	0.3	1.2
Conditioned reinforcement - actives	0.2	0.4	0.8	-0.6	-0.7	0.1	-0.4	-0.6	-0.8	-0.5	0.9
Conditioned reinforcement - inactives	0.3	0.5	1.1	-0.6	-1.1	-0.3	-0.9	-0.8	0.1	-0.9	0.1
Conditioned locomotion	0.1	0.1	0.5	0.7	0.0	-0.1	0.4	0.5	-0.0	0.3	0.2
Patch foraging indifference point 0 sec	0.3	0.6	1.4	-0.1	-0.8	-1.2	-1.2	-0.6	0.8	-0.4	-0.7
Patch foraging indifference point AUC	1.8	2.7	5.1	-2.1	-1.9	0.2	-2.2	-2.3	-0.7	-1.6	0.5
Delay disc. indifference point, 0s delay	3.2	3.6	9.0	-2.1	-0.1	1.2	-1.6	-1.3	-2.9	1.0	3.0
Delay disc. indifference point, 16s delay	1.0	1.1	3.9	-2.0	0.7	1.4	-1.2	-1.0	-0.2	-0.1	-0.4
Delay disc. indifference point, 2s delay	1.6	1.8	5.3	-2.3	-0.5	0.6	-1.4	-1.9	-1.3	-0.0	0.9
Delay disc. indifference point, 24s delay	1.8	2.0	5.1	-1.1	-0.5	-0.4	-1.4	-1.0	1.7	-1.9	-2.3
Delay disc. indifference point, 4s delay	2.5	2.6	7.2	-2.7	-1.1	0.2	-2.1	-2.5	-1.1	-0.6	0.6
Delay disc. indifference point, 8s delay	1.6	1.9	6.4	-2.5	0.4	1.8	-1.5	-1.4	-0.9	-0.6	0.1
Indifference point function ln k	0.3	0.6	1.7	0.9	0.2	-1.0	0.4	0.3	0.7	1.3	-0.5
Indifference point function log k	0.3	0.6	1.7	0.9	0.2	-1.0	0.4	0.3	0.7	1.3	-0.5
Patch foraging total patch changes 0 sec	0.4	0.8	1.8	-0.2	-1.0	-1.3	-1.3	-0.7	0.8	-0.4	-0.6
Patch foraging total patch changes 12 sec	2.0	2.6	5.4	-0.9	-1.9	-1.4	-2.1	-1.3	1.0	-2.3	-1.2
Patch foraging total patch changes 18 sec	0.6	1.0	2.5	-1.3	-0.3	0.7	-1.2	-0.7	-0.7	-1.6	0.5
Patch foraging total patch changes 24 sec	1.3	2.1	4.5	-1.1	-1.8	-1.1	-2.1	-1.4	0.8	-1.8	-1.0
Patch foraging total patch changes 6 sec	1.4	2.2	3.4	-0.5	-1.9	-1.7	-1.8	-1.2	1.3	-1.7	-1.3
Patch foraging time to switch 0 sec	1.3	2.6	9.1	0.8	3.0	1.6	1.9	2.2	-0.1	0.3	-0.4
Patch foraging water rate 0 sec	1.3	2.8	6.7	-1.3	-2.6	-1.5	-2.5	-1.9	-0.1	-1.4	0.5
Patch foraging water rate 12 sec	1.4	2.9	11.2	-0.1	-3.3	-2.5	-1.7	-1.7	0.3	-0.8	0.2
Patch foraging water rate 18 sec	0.8	1.2	3.5	0.2	-1.7	-1.9	-1.1	-0.8	0.9	0.1	-0.6
Patch foraging water rate 24 sec	1.1	1.6	5.1	0.8	-2.2	-2.3	-0.7	-0.8	0.5	0.8	0.3
Patch foraging water rate 6 sec	0.7	1.1	2.6	-0.7	-1.6	-0.9	-1.3	-1.1	-0.7	0.0	1.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.6	0.1	-0.4	-0.0	0.2	0.4	0.4	-0.4
Distance traveled before self-admin	0.7	1.0	2.6	0.9	-0.9	-1.6	0.0	0.3	1.1	-1.3	-0.8
Distance traveled after self-admin	0.1	0.1	0.3	-0.1	-0.4	0.1	-0.1	-0.5	-0.3	0.5	0.5
Extensor digitorum longus weight	0.1	0.3	0.6	0.8	-0.7	-0.7	0.3	0.3	0.8	0.1	-0.5
Bone: elastic displacement	0.3	0.3	0.8	0.6	0.5	-0.0	0.9	0.6	0.4	-0.7	-0.4
Bone: elastic work	2.1	2.7	6.2	2.5	0.6	-0.9	2.1	2.0	1.8	-0.2	-1.6
Bone: endosteal estimation	1.3	2.8	5.2	0.2	2.3	1.8	1.5	1.5	-1.5	2.3	1.4
Bone: endosteal perimeter	0.7	1.6	2.9	0.2	1.7	1.6	1.1	1.2	-1.4	0.9	1.3
Epididymis fat weight	2.9	10.1	27.6	2.7	-3.0	-5.3	-0.3	-0.1	4.3	-1.9	-3.9
Delta time in closed arm before/after self-admin	0.6	0.6	1.7	0.7	0.3	-0.8	0.3	0.4	1.1	-0.2	-1.3
Delta time in open arm before/after self-admin	1.7	1.7	4.3	-1.9	-1.2	-0.0	-1.5	-2.1	-0.9	0.3	0.9
Diff in mean of infusions in LGA sessions	0.9	1.1	2.3	1.3	0.5	0.1	1.2	0.8	-1.0	1.5	1.2
Delay discount exponential model param	2.5	2.7	9.3	3.0	0.2	-1.1	2.1	2.2	0.4	1.3	0.5
Extinction: sum of active levers before priming	0.3	0.3	0.9	-0.5	0.2	0.7	-0.1	-0.2	-0.9	0.4	0.7
Active lever presses in extinction session 6	0.1	0.1	0.3	0.1	-0.5	0.3	0.2	-0.3	-0.2	0.6	0.2
Bone: final force	0.4	0.7	2.0	1.4	0.1	-0.3	0.7	1.4	0.4	-0.7	-0.3
Bone: final moment	0.3	0.5	1.4	1.1	-0.0	-0.3	0.4	1.2	0.4	-0.8	-0.3
Food consumed during 24 hour testing period	0.1	0.1	0.3	-0.0	-0.2	-0.5	-0.5	-0.3	0.1	-0.1	-0.1
Glucose	0.9	1.4	3.1	1.3	-1.8	-1.6	-0.1	-0.2	1.4	-0.6	-1.0
Heart weight	0.6	1.0	1.9	1.0	0.0	-1.1	0.3	0.8	1.3	-1.2	-1.4
Delay discount hyperbolic model param	2.4	2.7	9.0	3.0	0.2	-1.1	2.1	2.1	0.6	1.4	0.3
Intermittent access intake day 1-15 change	0.9	1.8	5.2	0.7	1.4	1.2	1.4	1.0	-1.0	2.3	1.2
Intermittent access intake escalation	1.4	2.9	7.6	1.0	1.8	1.5	1.9	1.4	-1.2	2.8	1.5
Intermittent access intake escalation 2	1.1	1.3	2.8	-0.0	1.7	1.6	0.9	0.9	-1.0	1.3	0.9
Intermitt. access day 1 inactive lever presses	0.3	1.2	3.5	1.9	0.2	-0.7	1.4	1.1	0.5	1.5	-0.1
Intermitt. access day 15 inactive lever presses	0.2	0.3	0.9	0.1	-0.5	-0.4	-0.4	-0.3	-0.7	0.6	1.0
Intermitt. access escalation Index	0.3	0.4	0.6	-0.2	-0.7	-0.4	-0.6	-0.7	-0.5	0.7	0.7
Intermittent access day 1 total infusions	0.2	0.3	1.0	0.1	-0.6	-0.3	-0.1	-0.4	1.0	-0.0	-0.9
Intermittent access day 15 total infusions	0.7	1.1	3.5	0.8	0.8	0.8	1.4	0.8	-0.2	1.9	0.6
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.7	0.1	0.6	0.8	0.8	0.4	-0.1	0.7	0.3
Intermittent access total infusions	0.1	0.1	0.5	-0.2	0.1	0.5	0.2	-0.2	0.2	0.7	-0.0
Intermittent access day 1 locomotion	0.9	1.1	3.0	0.7	-1.0	-1.2	0.1	-0.1	1.7	-0.6	-1.6
Intermittent access day 15 total locomotion	0.3	0.5	1.9	0.3	0.1	-0.2	0.3	0.2	1.2	-0.7	-1.4
Intermittent access total locomotion	0.4	0.4	1.5	0.4	0.0	-0.2	0.3	0.3	1.2	-0.5	-1.2
Intermittent access standard deviation	0.3	0.5	1.9	-0.0	1.4	1.2	0.6	0.8	-0.0	0.2	-0.2
Left kidney weight	0.4	1.9	5.6	1.0	-1.5	-2.4	-0.4	-0.3	1.9	0.3	-1.6
Right kidney weight	0.6	2.7	6.5	0.1	-2.5	-2.6	-1.7	-1.4	1.5	-0.7	-1.2
Cocaine induced anxiety	0.5	0.7	1.7	0.7	0.8	0.4	1.1	0.6	-0.6	1.3	0.8
Post-drug Anxiety	1.6	1.7	4.4	1.2	2.1	0.8	1.5	1.8	-0.3	1.0	0.3
Baseline Anxiety	0.7	0.8	2.8	-0.0	1.7	1.3	0.4	1.2	-0.3	-0.5	0.0
Tail length	0.7	2.9	6.4	2.5	-0.1	-1.7	1.2	1.7	2.3	-0.6	-2.0
Length with tail	1.7	7.5	18.9	4.3	1.8	-1.0	3.4	4.0	2.4	0.5	-1.8
Length without tail	1.2	4.0	9.2	3.0	1.1	-0.8	2.2	2.8	2.2	-0.3	-1.7
Times rat made contact with spout	0.5	0.5	1.4	0.3	-0.5	-0.6	-0.4	-0.3	1.2	-0.6	-1.2
Lifetime Intake	0.2	0.3	1.4	-0.3	0.2	0.7	0.2	-0.2	-0.2	1.2	0.2
Liver weight, left	1.4	2.3	4.4	-1.1	-1.2	-0.9	-1.4	-1.2	1.7	-2.0	-2.1
Liver weight, right	1.3	2.2	5.3	1.6	-0.6	-1.1	1.2	0.7	2.3	-1.0	-2.3
Locomotor activity	1.4	2.3	6.4	2.5	0.4	-1.1	1.3	2.0	1.6	-0.4	-1.3
Locomotor testing distance	1.3	2.4	5.5	2.3	-0.0	-1.7	1.1	1.9	1.8	-1.1	-1.3
Locomotor testing rearing	0.3	0.7	1.9	1.4	-1.1	-1.2	0.6	0.7	0.3	0.2	0.2
Locomotion in novel chamber	1.1	1.5	3.7	-1.6	-1.3	-0.5	-1.7	-1.9	0.3	-0.4	-0.7
Locomotion in novel chamber post-restriction	1.4	2.2	6.0	-2.4	0.6	2.4	-1.2	-1.5	-1.3	0.4	0.7
Fecal boli incidents, locomotor time 1	0.2	0.3	0.8	-0.6	-0.6	-0.3	-0.9	-0.5	-0.2	-0.7	0.2
Change in fecal boli incidents, locomotor task	0.7	0.7	2.5	-0.6	0.6	1.3	0.1	-0.6	-0.4	1.6	0.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.3	-0.4	0.2	-0.3	-0.5	0.1	0.6	-0.1
Bouts of movement, locomotor time 1	0.8	0.9	2.1	-0.8	-1.1	-0.5	-1.4	-1.3	0.7	-0.1	-0.8
Total resting periods, locomotor time 1	0.3	0.3	1.0	-0.3	-0.7	-0.4	-1.0	-0.7	0.4	0.1	-0.3
Rest time, locomotor task time 1	1.1	1.4	3.0	-1.3	-0.5	0.5	-1.7	-1.2	-1.4	-0.6	1.5
Distance moved, locomotor task time 1	0.2	0.3	0.6	0.3	-0.8	-0.5	0.7	-0.1	0.8	-0.0	-0.6
Vertical activity count, locomotor time 1	0.2	0.6	1.7	0.6	-0.2	-0.2	1.3	0.2	1.0	0.2	-1.1
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.5	0.6	0.2	0.0	0.4	0.3	0.5	0.7	-0.3
Bouts of movement, locomotor time 2	1.0	1.5	2.7	-0.7	-1.1	-1.2	-1.2	-0.9	1.5	-1.4	-1.6
Total resting periods, locomotor time 2	0.6	1.1	2.3	-0.6	-0.9	-1.1	-1.0	-0.8	1.4	-0.9	-1.5
Rest time, locomotor task time 2	0.4	0.5	1.6	-0.8	-0.1	0.1	-1.3	-0.8	-0.8	-0.1	0.6
Distance moved, locomotor task time 2	0.2	0.3	0.7	0.0	-0.2	0.2	0.8	0.1	-0.5	0.6	0.8
Vertical activity count, locomotor time 2	0.6	0.8	1.9	0.2	0.9	1.2	1.4	0.6	-0.7	0.9	0.6
Light reinforcement 1	0.2	0.5	1.0	0.0	-0.8	-1.0	-0.4	-0.2	1.0	-0.6	-1.0
Light reinforcement 2	0.3	0.4	1.2	1.0	-0.2	-1.1	0.6	0.5	0.5	0.7	-0.1
Bone: marrow area	1.2	2.7	5.3	0.3	2.3	1.9	1.5	1.6	-1.4	2.1	1.3
Bone: maximum diameter	0.4	0.8	2.4	-0.7	0.5	1.1	-0.1	0.0	-1.6	-0.2	1.5
Bone: maximum force	0.8	1.4	3.9	2.0	0.7	-0.2	1.4	1.9	0.7	0.2	-0.6
Bone: maximum moment	0.6	1.0	3.2	1.8	0.4	-0.3	1.1	1.6	0.7	0.2	-0.6
Mean time between licks in bursts	0.4	0.9	2.8	-0.5	1.7	1.0	0.6	0.7	-1.0	0.6	0.8
Mean num. licks in bursts	0.5	0.8	2.2	-1.4	-0.6	0.0	-1.5	-1.3	-0.1	-0.4	-0.3
Cd content in liver	0.8	0.9	3.6	-0.2	0.6	0.5	0.6	-0.2	-1.1	1.9	1.1
Co content in liver	0.3	0.4	0.9	0.6	-0.3	-0.8	0.7	-0.3	0.6	0.9	-0.5
Cu content in liver	0.4	0.5	1.3	-1.1	-0.2	0.4	-0.4	-0.9	-0.9	0.5	0.7
Fe content in liver	1.3	1.6	3.9	-0.4	-1.5	-1.4	-1.0	-0.9	1.1	-2.0	-1.3
K content in liver	2.2	2.1	4.8	1.8	1.6	-0.3	2.1	2.2	0.8	0.6	-0.6
Mg content in liver	0.6	0.6	1.6	0.3	-0.1	-0.8	0.0	0.4	1.0	-1.3	-1.1
Mn content in liver	0.4	0.5	1.9	-0.1	0.8	0.2	-0.3	0.2	-0.6	1.4	0.7
Na content in liver	0.9	1.0	2.2	0.8	-0.6	-1.2	0.3	0.4	1.5	-1.1	-1.4
Rb content in liver	0.8	0.9	3.3	-0.6	1.6	1.8	0.6	0.8	-0.5	0.4	0.0
Se content in liver	1.5	1.8	4.7	-1.8	-1.1	-0.5	-2.2	-1.6	0.0	-1.5	-0.3
Sr content in liver	0.7	0.6	1.5	1.0	0.2	0.2	1.2	0.8	-0.5	0.9	0.8
Zn content in liver	0.5	0.5	1.2	-1.1	-0.6	-0.1	-0.8	-0.8	0.0	-1.1	-0.2
Bone: minimum diameter	0.9	1.6	3.6	0.5	1.7	1.9	1.2	1.5	-1.3	0.0	1.1
Time in familiar zone, hab. session 1	2.4	2.3	4.1	-0.7	-2.0	-1.9	-1.2	-1.7	1.5	-0.8	-1.6
Time in novel zone, hab. session 1	2.1	2.1	4.0	0.3	1.5	1.5	0.8	1.1	-1.7	1.7	2.0
Total zone transitions, hab. session 1	0.5	0.7	3.1	0.2	-1.8	-1.1	-0.5	-0.7	0.3	-0.4	-0.1
Total locomotion distance, hab. session 1	0.4	0.6	3.0	0.3	-1.7	-1.0	-0.5	-0.5	0.1	-0.5	0.2
Locomotion velocity, hab. session 1	0.3	0.4	2.2	0.4	-1.5	-0.8	-0.2	-0.3	0.1	-0.6	0.2
Time in familiar zone, hab. session 2	0.7	0.7	1.5	0.8	0.8	-0.4	1.0	0.6	1.1	0.5	-1.2
Time in novel zone, hab. session 2	0.9	0.9	1.9	-0.8	-1.3	-0.2	-1.4	-0.9	-0.9	-0.4	1.1
Total zone transitions, hab. session 2	0.3	0.4	1.3	1.1	0.2	-0.1	0.9	1.0	-0.3	0.2	0.5
Total locomotion distance, hab. session 2	0.1	0.1	0.5	0.7	-0.2	-0.4	0.3	0.4	0.1	0.1	0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.4	0.6	0.2	-0.0	0.4	0.5	-0.0	0.1	0.1
Novel to familiar place preference ratio	0.0	0.0	0.1	0.4	0.1	0.2	0.3	0.2	0.1	0.0	0.1
Novelty place preference	0.1	0.1	0.3	0.5	-0.0	-0.1	0.3	0.4	0.5	-0.3	-0.4
Time in novel zone, NPP test	0.1	0.1	0.2	0.3	-0.3	-0.2	-0.1	0.1	0.5	-0.3	-0.3
Total zone transitions, NPP test	0.4	0.6	2.2	0.3	-1.2	-0.8	-0.3	-0.0	0.4	-1.5	-0.3
Total locomotion distance, NPP test	0.3	0.4	1.1	0.6	-1.1	-0.8	-0.2	0.1	0.2	-1.0	0.1
Locomotion velocity, NPP test	0.5	0.7	1.8	1.3	-0.5	-0.7	0.7	1.1	0.5	-1.2	-0.2
Intraocular pressure	1.0	1.5	7.4	0.5	0.3	0.3	0.9	-0.1	-1.1	2.7	1.4
Delta distance traveled before/after self-admin	0.9	1.0	3.2	-0.4	0.4	1.2	0.3	-0.5	-1.0	1.8	1.1
Delta ambulatory time before/after self-admin	1.1	1.3	4.1	-0.2	0.9	1.6	0.7	-0.2	-1.1	2.0	1.3
Parametrial fat weight	1.8	4.3	12.9	2.0	-2.8	-3.6	-0.1	-0.5	2.5	0.0	-1.8
Pavlov. Cond. lever latency	0.8	1.0	3.2	0.6	1.2	0.6	0.7	0.7	-0.8	1.8	0.9
Pavlov. Cond. magazine entry latency	0.4	0.6	1.6	-1.3	-0.6	0.4	-0.7	-0.9	-0.8	0.0	0.8
Pavlov. Cond. change in total contacts	0.4	0.5	1.2	-0.8	-1.1	-0.2	-0.8	-1.0	-0.2	-0.1	0.2
Pavlov. Cond. index score	0.4	0.5	1.2	-0.9	-1.1	-0.3	-0.7	-0.9	0.0	-0.9	0.0
Pavlov. Cond. latency score	0.5	0.6	1.4	-1.0	-1.0	-0.2	-0.8	-0.8	-0.0	-1.2	-0.0
Pavlov. Cond. lever contacts	0.9	1.0	2.0	-0.4	-1.4	-1.0	-0.7	-0.9	1.0	-1.3	-1.0
Pavlov. Cond. magazine entry number	0.4	0.5	1.0	1.0	0.9	-0.1	0.7	1.0	0.5	-0.1	-0.7
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	0.2	-0.2	-0.3	-0.2	-0.1	0.6	-0.4	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.4	-0.9	-1.2	-0.2	-0.7	-1.0	-0.1	-0.4	0.1
Pavlov. Cond. response bias	0.4	0.5	1.5	-0.6	-1.2	-0.4	-0.7	-1.0	0.4	-0.5	-0.3
Pavlov. Cond. lever latency	0.1	0.2	0.6	-0.8	0.2	0.4	-0.4	-0.7	-0.1	0.3	-0.2
Pavlov. Cond. magazine entry latency	0.6	0.8	2.4	0.9	-0.9	-1.2	0.3	0.5	0.6	-1.5	-0.3
Pavlov. Cond. change in total contacts	0.3	0.5	1.0	1.0	-0.6	-1.0	0.4	0.7	0.6	-0.8	-0.3
Pavlov. Cond. index score	0.6	0.8	2.3	0.9	-1.0	-1.2	0.1	0.5	0.6	-1.5	-0.4
Pavlov. Cond. latency score	0.7	0.9	2.2	0.9	-1.2	-1.3	0.0	0.4	0.7	-1.5	-0.4
Pavlov. Cond. lever contacts	0.2	0.3	0.8	0.9	-0.3	-0.6	0.5	0.8	0.4	-0.6	-0.1
Pavlov. Cond. magazine entry number	0.6	0.7	2.9	-0.8	0.6	1.0	-0.3	-0.7	-0.6	1.7	0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.7	-0.1	0.8	0.4	0.0	0.1	0.0	0.7	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.3	0.9	-1.1	-1.3	0.1	0.4	0.9	-1.5	-0.6
Pavlov. Cond. response bias	0.3	0.4	1.2	0.7	0.2	-0.3	0.6	1.1	0.2	-1.0	-0.0
Time in closed arm before self-admin	0.7	0.9	1.9	0.9	0.4	-0.1	0.9	0.8	-1.0	1.2	1.4
Time in closed arm after self-admin	1.3	1.4	3.3	1.8	-0.4	-1.8	0.9	0.7	-0.3	1.5	0.9
Time in open arm before self-admin	0.9	1.0	3.6	0.1	-0.4	0.0	0.0	-0.0	1.6	-1.3	-1.9
Time in open arm after self-admin	0.7	0.8	2.3	-1.2	-1.0	0.2	-0.9	-1.5	0.5	-0.2	-0.8
Bone: periosteal estimation	0.7	1.4	2.0	0.1	1.4	1.4	1.0	1.2	-1.4	0.8	1.4
Bone: periosteal perimeter	0.5	0.8	2.2	1.1	0.8	0.4	1.4	1.5	-0.2	-0.2	0.3
Bone: post-yield work	0.7	1.0	2.4	1.6	0.2	-0.9	1.1	1.1	1.0	0.9	-0.7
Progressive ratio test 1 active lever presses	0.7	0.9	2.2	1.3	-0.0	-0.6	1.5	0.7	0.3	1.4	0.1
Progressive ratio test 1 breakpoint	0.8	0.9	2.3	1.3	0.1	-0.5	1.5	0.8	0.3	1.5	0.1
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.8	0.8	-0.5	-0.9	0.3	0.3	0.6	0.4	-0.2
Progressive ratio test 2 active lever presses	0.6	0.7	1.6	1.2	-0.7	-0.8	1.2	0.2	0.3	1.3	0.3
Progressive ratio test 2 breakpoint	0.7	0.8	1.6	1.3	-0.7	-0.9	1.2	0.2	0.5	1.2	0.2
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.6	-0.2	-0.8	-0.4	-0.2	-0.5	0.0	0.3	0.3
Incentive Sensitization - Responses	0.6	0.9	2.8	0.6	-1.7	-1.5	-0.1	-0.7	0.9	-0.0	-0.4
Incentive Sensitization - Breakpoint	0.6	0.8	2.7	0.5	-1.7	-1.4	-0.2	-0.7	0.9	-0.2	-0.4
Sum of active levers in priming session hrs 5-6	3.2	3.0	8.1	-2.8	0.6	2.6	-1.9	-1.7	-1.4	-0.3	0.5
Progressive ratio	0.9	1.3	4.3	0.9	1.8	0.9	1.0	2.1	0.5	-0.4	-0.6
Food seeking constrained by brief footshock	1.9	2.3	4.8	1.1	1.9	1.5	2.2	2.0	-0.4	1.3	0.8
Seeking ratio, punishment vs. effort	0.4	0.5	1.4	-0.3	-0.2	0.6	0.2	-0.5	-1.0	1.1	1.2
Retroperitoneal fat weight	1.8	7.8	19.4	0.7	-3.9	-4.4	-2.3	-1.7	3.0	-1.8	-2.6
Reaction time number correct	1.7	3.2	8.3	-2.7	-1.5	0.3	-2.9	-2.3	-0.9	-1.3	0.7
Reaction time mean minus median	0.5	1.3	3.8	1.4	1.2	0.6	1.5	1.9	-0.2	-0.0	0.4
Reaction time mean minus median AUC	0.8	2.0	4.7	1.5	1.7	1.0	1.8	2.2	-0.8	0.8	1.0
Reaction time num false alarms	0.5	0.7	2.1	-1.2	-0.4	-0.0	-1.4	-1.0	0.2	-1.0	-0.4
Reaction time num false alarms AUC	0.6	0.9	2.3	-1.2	-0.7	-0.4	-1.5	-1.2	0.4	-1.0	-0.6
Reaction time trials correct on left	1.7	3.2	8.3	-2.7	-1.5	0.3	-2.9	-2.3	-0.9	-1.3	0.7
Reaction time trials on left	1.7	3.2	8.3	-2.7	-1.5	0.2	-2.9	-2.2	-0.8	-1.4	0.6
Reaction time mean	1.7	2.7	6.7	2.6	1.1	-0.4	2.6	2.2	0.9	0.8	-0.6
Reaction time mean AUC	1.6	2.6	6.4	2.5	1.2	-0.2	2.5	2.3	0.7	0.7	-0.3
Median of all reaction times	1.7	2.5	6.0	2.5	0.9	-0.7	2.4	1.9	1.3	0.7	-1.0
Reaction time omissions	0.5	0.7	1.4	1.0	-0.2	-0.6	0.3	0.6	1.2	-1.2	-1.1
Reaction time false alarm rate	0.1	0.1	0.5	0.2	0.2	-0.3	0.1	0.1	0.6	-0.1	-0.7
Reaction time premature initiation rate	0.3	0.4	1.0	0.3	-0.6	-1.0	-0.3	-0.1	0.8	0.1	-0.9
Reaction time premature initiations	0.5	0.9	2.3	-0.7	-1.2	-0.9	-1.5	-0.9	0.5	-0.6	-0.6
Std. dev. reaction times	1.3	2.3	5.6	2.4	1.2	0.1	2.3	2.4	0.6	0.4	-0.2
Reaction time trials completed	1.7	3.2	8.3	-2.7	-1.5	0.2	-2.9	-2.2	-0.8	-1.4	0.6
Reaction time trials AUC	1.6	3.0	7.9	-2.6	-1.6	0.1	-2.8	-2.2	-0.7	-1.4	0.6
Run reversals in cocaine runway, females	0.7	0.7	1.1	0.5	0.8	1.0	1.0	1.0	-0.6	0.3	0.9
Run reversals in cocaine runway, males	0.3	0.3	0.7	-0.1	-0.7	-0.8	-0.8	-0.4	0.1	0.3	0.1
Latency to leave start box in cocaine runway	2.4	2.7	6.5	2.4	-0.0	-1.3	2.3	1.5	0.2	2.6	0.5
Latency to leave start box in cocaine runway, F	0.8	1.0	2.8	1.2	-0.2	-1.0	1.2	0.9	0.0	1.7	0.4
Latency to leave start box in cocaine runway, M	2.0	1.9	5.2	2.3	-0.3	-1.2	1.9	1.0	0.2	1.8	0.3
Std. dev. time between licks in bursts	0.5	0.6	1.3	-0.7	0.6	0.7	0.2	-0.2	-1.1	1.2	1.0
Total sessions with >9 infusions	0.5	0.6	2.4	-0.2	0.1	0.6	0.1	-0.0	-0.8	1.5	1.0
Short access day 1 total inactive lever presses	0.3	0.4	0.7	0.2	-0.9	-0.8	-0.2	-0.5	0.8	0.0	-0.7
Short access day 10 total inactive lever presses	0.8	1.9	3.9	-0.4	-1.6	-1.7	-2.0	-1.0	0.7	-1.8	-0.8
Short access day 1 total infusions	0.5	0.6	1.5	-0.4	-1.2	-0.6	-0.5	-1.1	-0.3	1.1	0.5
Short access day 10 total infusions	0.3	0.3	1.0	-0.2	0.5	1.0	0.4	-0.0	-0.3	1.0	0.3
Short access total infusions	0.5	0.6	2.5	-0.6	0.1	0.8	-0.2	-0.5	-0.8	1.6	0.8
Short access day 1 locomotion	0.1	0.2	0.8	0.0	-0.2	0.2	0.2	-0.1	-0.4	0.9	0.5
Short access day 10 total locomotion	0.1	0.2	0.5	0.0	0.2	0.0	0.2	0.1	0.6	-0.7	-0.7
Short access total locomotion	0.0	0.0	0.0	-0.0	0.1	0.2	0.1	0.2	-0.0	0.0	0.0
One hour access (0.3 mA shock)	0.3	0.4	1.1	-0.8	-0.7	0.4	-0.3	-1.0	0.1	0.7	-0.2
Compulsive drug intake	0.8	0.9	2.8	-1.2	-1.0	-0.5	-1.7	-1.4	0.0	-0.3	-0.3
One hour access (shock baseline)	0.2	0.3	1.1	0.4	0.3	0.5	1.0	0.3	-0.0	1.0	0.4
Social response proportion	0.4	0.4	1.3	-0.5	0.8	0.5	0.2	0.1	0.8	-0.7	-1.1
Social responses	0.8	1.0	3.6	0.1	0.5	0.3	0.6	0.4	1.5	-1.1	-1.9
Social time	2.0	2.8	6.0	-2.3	-2.0	-0.3	-2.2	-2.4	0.2	-1.3	-0.8
Soleus weight	0.1	0.3	0.8	0.7	-0.8	-0.9	0.6	0.2	0.6	-0.1	-0.3
Bone: stiffness	0.1	0.2	0.3	0.6	-0.1	-0.3	0.0	0.4	0.6	0.2	-0.5
Tibialis anterior weight	0.3	0.9	3.0	-0.0	-1.7	-1.4	-0.8	-0.7	0.5	-0.8	-0.2
Time to tail flick, vehicle, before self-admin	0.4	0.5	2.5	-0.0	0.4	0.4	0.3	0.8	-0.3	-1.6	0.2
Time to tail flick, vehicle, after self-admin	0.6	0.9	1.9	0.5	1.4	1.0	1.4	1.2	-0.5	-0.2	0.5
Time to tail flick, test, before self-admin	5.2	5.4	10.6	-3.0	-0.2	2.5	-1.4	-2.3	-3.3	1.4	2.9
Time to tail flick, test, after self-admin	0.6	0.6	2.1	-0.3	-0.9	-0.3	-0.3	-0.5	-1.3	0.0	1.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.3	0.1	0.5	0.1	-0.3	-0.6	0.1	0.5
Delta time to tail flick, test, before/after SA	2.6	2.7	5.9	2.2	-0.8	-2.4	0.9	1.2	2.1	-1.0	-1.7
Tibia length	0.5	1.4	4.1	-1.0	-2.0	-0.6	-1.5	-1.8	-0.1	-0.2	0.3
Ambulatory time before self-admin	1.3	2.0	4.6	0.3	-1.9	-2.1	-0.9	-0.5	1.4	-1.8	-1.2
Ambulatory time after self-admin	0.2	0.2	0.8	0.3	-0.9	-0.5	-0.3	-0.3	-0.2	-0.4	0.6
Bone: tissue strength	1.1	1.1	2.7	0.2	-1.0	-1.2	-0.7	-0.6	1.5	-0.7	-1.6
Total heroin consumption	0.2	0.3	0.6	0.7	0.4	0.3	0.8	0.6	0.4	-0.1	-0.6
Bone: trabecular number	0.9	1.5	3.4	0.0	1.8	1.9	0.7	1.4	-1.2	-0.8	1.0
Bone: trabecular spacing	1.5	2.0	3.3	-0.9	-1.8	-1.1	-1.7	-1.7	1.3	-1.1	-1.4
Bone: trabecular thickness	2.6	3.3	7.9	0.2	2.8	2.3	1.3	1.9	-2.0	0.8	1.8
Bone: trabecular tissue density	3.4	5.1	11.7	-3.0	-2.4	-0.1	-3.4	-3.2	-1.4	-0.1	1.4
Water consumed over 24 hours	1.5	2.0	3.3	-0.4	-1.4	-1.4	-1.6	-1.1	1.5	-1.8	-1.6
Number of responses in last shaping day	0.7	0.8	3.7	0.2	-0.8	-0.2	0.4	-0.6	-0.6	1.9	0.9