Hub : Genes

Slc24a3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Slc24a3 0.07 0.05 7.7e-03 0 0.01 0 0 3.4e-01 3.0e-02 2.7e-01 1.1e-01
2 pVTA gene expression Slc24a3 0.06 0.04 2.9e-04 0.02 0.05 0.03 0.03 4.8e-03 1.1e-04 1.2e-03 2.1e-03
3 RMTg gene expression Slc24a3 0.24 0.1 2.4e-05 0.1 0.22 0.13 0.12 1.1e-03 1.8e-06 2.3e-04 3.5e-04
4 Brain gene expression Slc24a3 0.3 0.1 6.1e-14 0.06 0.16 0.13 0.15 1.4e-06 1.3e-14 2.9e-12 1.5e-13
5 IC gene expression Slc24a3 0.37 0.12 1.6e-09 0.07 0.26 0.25 0.23 6.6e-04 2.6e-11 7.6e-11 2.9e-10
6 PL gene expression Slc24a3 0.09 0.04 3.9e-09 0.06 0.08 0.08 0.06 7.6e-07 4.6e-09 4.6e-09 1.7e-07
7 OFC gene expression Slc24a3 0.24 0.13 5.9e-03 0.1 0.09 0.07 0.12 2.1e-03 3.5e-03 7.7e-03 7.7e-04
8 Adipose gene expression Slc24a3 0.51 0.09 0.0e+00 0.22 0.29 0.26 0.27 8.5e-24 6.8e-32 8.8e-29 9.0e-30
9 BLA gene expression Slc24a3 0.16 0.07 1.6e-06 0.13 0.1 0.1 0.1 1.7e-07 3.5e-06 6.8e-06 6.6e-06
10 NAcc gene expression Slc24a3 0.06 0.03 2.8e-06 0.02 0.05 0.04 0.04 8.1e-04 1.1e-07 3.2e-07 1.9e-06
11 RMTg mRNA stability Slc24a3 0.39 0.24 3.0e-03 0.03 0.02 0.01 0.01 5.6e-02 1.0e-01 2.2e-01 1.3e-01
12 Brain mRNA stability Slc24a3 0.07 0.04 4.7e-05 0.05 0.03 0.04 0.04 3.9e-05 6.6e-04 3.2e-04 1.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.72.85.2-0.9-1.0-2.2-1.7-0.10.92.2-1.4-2.3-1.4-2.2-2.3
Area under the delay curve2.32.75.32.32.21.92.11.41.3-0.21.81.61.61.21.1
BMI with tail1.13.79.0-3.0-2.5-2.6-2.4-2.1-2.6-0.0-1.6-1.6-0.1-0.3-0.3
BMI without tail0.92.88.2-2.4-2.4-2.9-2.0-1.3-2.10.9-0.8-1.10.3-0.8-0.8
Body weight2.711.830.7-4.6-4.5-5.5-4.0-2.1-2.22.2-3.0-3.4-1.3-3.1-2.7
Weight adjusted by age2.53.88.5-1.0-1.1-2.3-1.20.71.52.7-2.0-2.3-1.6-2.9-2.5
Bone surface1.32.35.6-1.5-1.5-2.4-2.1-0.8-0.41.7-0.8-1.8-0.9-1.7-1.5
Bone volume2.23.97.7-1.6-1.7-2.8-2.2-0.50.32.4-1.5-2.4-1.6-2.5-2.3
Breakpoint value in progressive ratio session0.70.92.6-0.6-0.40.6-0.1-1.0-1.6-1.30.10.80.41.41.3
Number of licking bursts0.71.12.11.41.10.91.41.40.90.31.01.41.10.50.1
Context. condit. distance diff. score2.32.85.4-2.0-1.8-2.0-1.6-0.20.31.4-2.2-0.6-1.3-2.3-2.3
Locomotion velocity, session 10.30.41.50.50.30.60.1-0.2-0.7-0.41.20.20.40.80.7
Locomotion distance, session 10.70.82.01.31.11.40.70.60.8-0.61.21.10.30.60.4
Locomotion velocity, session 21.51.75.92.11.91.30.80.50.5-0.42.40.51.21.21.0
Locomotion distance, session 20.30.42.51.10.20.2-0.20.00.30.41.6-0.5-0.4-0.1-0.2
Locomotion velocity, session 30.60.61.61.11.20.81.01.11.30.30.40.30.2-0.0-0.5
Locomotion distance, session 30.40.41.40.10.4-0.10.10.81.20.6-0.40.2-0.1-0.8-1.1
Stereotopy head waving bouts, day 31.01.23.10.60.71.30.8-0.9-1.2-1.70.70.10.01.71.5
Stereotopy head waving duration, day 30.50.61.70.50.40.70.6-0.6-1.0-1.00.7-0.30.11.31.0
Locomotion velocity, session 70.80.92.60.60.3-0.30.51.21.51.6-0.10.1-0.1-1.2-1.4
Locomotion distance, session 70.70.92.7-0.9-0.7-0.6-0.40.30.80.7-1.6-0.1-1.1-1.3-1.3
Stereotopy head waving bouts, day 70.40.41.00.80.80.71.00.1-0.0-0.50.70.50.60.70.5
Stereotopy head waving duration, day 70.20.20.50.70.70.40.60.10.1-0.10.70.10.40.40.1
Locomotion velocity, session 80.10.10.2-0.3-0.40.0-0.2-0.4-0.40.00.20.3-0.2-0.0-0.3
Locomotion distance, session 81.01.44.3-0.5-0.8-1.1-0.90.61.11.5-0.7-0.3-0.9-2.0-2.1
Degree of sensitization distance0.50.51.4-1.1-1.0-0.3-0.6-0.8-0.6-0.3-1.2-0.2-1.1-0.20.1
Degree of sensitization stereotypy0.10.10.2-0.1-0.1-0.30.2-0.1-0.00.4-0.2-0.20.1-0.2-0.5
Conditioned locomotion0.40.51.0-0.5-0.7-0.9-0.2-0.2-0.21.0-0.6-0.8-0.6-0.9-0.7
Cocaine response after cond. corrected0.30.41.00.20.0-0.00.20.51.00.7-0.4-0.1-0.9-0.9-1.0
Cocaine response after cond. not corrected1.51.74.30.3-0.2-1.0-0.20.91.82.1-0.6-1.0-1.3-1.9-2.1
Cocaine response before conditioning0.81.03.10.4-0.2-1.4-0.70.40.91.80.2-1.7-0.5-1.2-1.1
Saline control response3.04.07.1-2.3-2.7-2.1-2.3-2.0-1.60.8-1.7-2.4-2.4-1.3-1.6
Bone: connectivity density0.71.12.6-0.9-0.7-1.2-1.6-0.70.10.8-1.0-1.5-1.1-1.0-1.0
Bone: cortical apparent density0.30.40.80.40.90.60.60.80.8-0.3-0.30.70.70.2-0.2
Bone: cortical area1.52.28.30.60.3-1.8-0.01.91.72.90.6-0.61.1-2.0-1.7
Bone: cortical porosity1.01.12.61.00.80.91.00.3-0.6-0.61.60.81.31.31.4
Bone: cortical porosity0.40.51.00.50.50.50.60.0-0.7-0.50.90.40.91.01.0
Bone: cortical thickness1.62.76.51.51.4-0.91.02.62.02.51.40.12.3-1.0-0.9
Bone: cortical thickness0.70.93.40.81.20.50.91.61.90.6-0.50.40.4-0.3-0.5
Bone: cortical tissue density0.20.30.50.20.70.50.50.70.7-0.4-0.50.60.40.1-0.2
Condit. Reinf. active minus inactive responses0.10.10.30.2-0.3-0.4-0.3-0.20.10.60.4-0.6-0.4-0.3-0.5
Condit. Reinf. active-inactive response ratio0.10.10.40.70.20.30.3-0.20.10.10.5-0.4-0.30.30.2
Condit. Reinf. active responses0.30.31.20.60.0-0.5-0.10.30.51.10.8-0.5-0.0-0.5-0.8
Condit. Reinf. inactive responses0.30.41.10.70.50.30.60.60.20.61.00.60.90.3-0.2
Incentive salience index mean0.80.93.21.50.9-0.10.31.01.11.21.8-0.10.8-0.3-0.6
Condit. Reinf. lever presses1.82.56.32.41.90.20.92.02.01.52.50.41.9-0.1-0.6
Condit. Reinf. active minus inactive responses1.31.75.1-0.6-1.1-2.3-1.1-0.2-0.52.20.4-2.0-0.0-1.4-1.2
Condit. Reinf. active-inactive response ratio0.40.51.40.1-0.5-0.9-0.5-0.6-0.90.81.2-1.10.2-0.00.1
Condit. Reinf. active responses0.71.04.1-0.0-0.1-1.6-0.30.70.32.00.3-1.20.7-1.2-1.2
Condit. Reinf. inactive responses0.50.71.70.20.8-0.50.51.31.11.1-0.30.01.0-0.7-0.9
Condit. Reinf. lever presses2.12.96.5-2.0-2.2-2.5-2.1-1.5-1.61.1-0.9-2.2-0.9-1.3-1.0
Condit. Reinf. lever reinforcers received0.60.83.0-0.1-0.2-1.5-0.30.3-0.21.70.7-1.20.8-0.8-0.9
Conditioned reinforcement - actives1.11.94.4-1.8-2.1-0.8-1.9-1.6-1.1-0.6-1.2-0.2-2.1-0.9-0.4
Conditioned reinforcement - inactives0.71.03.0-1.3-1.6-0.2-1.0-0.8-0.7-0.5-1.30.0-1.7-0.6-0.1
Conditioned locomotion0.20.20.50.1-0.10.3-0.4-0.6-0.6-0.70.70.30.00.40.7
Patch foraging indifference point 0 sec1.63.07.2-1.8-1.9-1.6-1.2-0.20.41.6-2.7-1.4-2.1-1.9-2.3
Patch foraging indifference point AUC1.52.14.01.71.81.82.00.90.4-0.61.61.61.51.41.2
Delay disc. indifference point, 0s delay2.42.76.82.11.81.21.71.00.50.02.61.92.21.11.4
Delay disc. indifference point, 16s delay1.61.83.92.01.81.81.61.01.0-0.41.40.91.01.20.9
Delay disc. indifference point, 2s delay1.61.84.01.71.41.31.40.70.3-0.62.01.51.61.11.3
Delay disc. indifference point, 24s delay2.73.06.12.22.31.82.42.22.50.10.92.01.00.1-0.1
Delay disc. indifference point, 4s delay1.31.42.61.51.51.21.61.41.20.11.01.11.40.60.8
Delay disc. indifference point, 8s delay1.21.42.51.51.41.41.60.90.7-0.11.21.41.20.90.9
Indifference point function ln k1.11.93.5-1.5-1.6-1.3-1.7-0.8-0.10.5-1.9-1.7-1.9-1.2-1.3
Indifference point function log k1.11.93.5-1.5-1.6-1.3-1.7-0.8-0.10.5-1.9-1.7-1.9-1.2-1.3
Patch foraging total patch changes 0 sec1.42.75.2-1.5-1.7-1.6-1.1-0.00.51.9-2.3-1.4-1.9-1.9-2.3
Patch foraging total patch changes 12 sec0.30.41.1-0.3-0.1-0.40.30.70.61.0-0.80.30.1-0.7-0.8
Patch foraging total patch changes 18 sec0.30.51.8-0.2-0.3-0.20.30.40.70.9-0.9-0.1-0.7-0.8-1.4
Patch foraging total patch changes 24 sec0.20.31.30.60.2-0.20.30.60.41.10.7-0.20.3-0.3-0.7
Patch foraging total patch changes 6 sec0.60.93.6-0.0-0.3-0.60.20.81.11.9-1.0-0.6-0.7-1.1-1.3
Patch foraging time to switch 0 sec0.10.21.00.10.1-0.2-0.20.2-0.30.20.80.61.00.20.3
Patch foraging water rate 0 sec0.20.41.30.80.60.40.80.91.10.7-0.1-0.4-0.2-0.4-0.4
Patch foraging water rate 12 sec1.02.16.71.91.60.01.12.02.61.90.7-0.30.4-1.3-1.2
Patch foraging water rate 18 sec1.11.76.31.81.10.71.01.62.51.50.50.2-0.6-1.1-0.9
Patch foraging water rate 24 sec0.40.61.90.80.51.01.40.81.20.1-0.30.5-0.6-0.5-0.3
Patch foraging water rate 6 sec1.01.44.91.11.00.21.01.72.21.4-0.3-0.2-0.3-1.2-1.3
Seeking ratio, delayed vs. immediate footshock0.81.02.9-0.1-0.11.10.1-1.0-1.5-1.50.80.70.31.71.2
Distance traveled before self-admin1.01.32.71.41.41.11.31.10.50.01.41.01.71.00.8
Distance traveled after self-admin1.61.94.21.51.71.01.81.91.10.71.31.32.10.40.3
Extensor digitorum longus weight0.72.85.6-1.7-1.7-2.4-1.8-0.30.11.9-1.5-1.7-1.2-2.2-1.9
Bone: elastic displacement1.21.42.80.71.11.31.20.1-0.5-1.30.91.41.51.51.7
Bone: elastic work0.50.62.90.50.60.10.70.3-0.4-0.11.20.91.70.70.9
Bone: endosteal estimation2.24.78.9-2.4-3.0-2.9-2.9-2.0-1.41.3-1.3-2.1-2.2-2.0-1.5
Bone: endosteal perimeter1.83.76.6-2.1-2.5-2.6-2.3-1.2-0.71.5-1.5-1.9-2.0-2.2-1.8
Epididymis fat weight2.27.614.5-3.8-3.7-3.8-3.6-2.8-3.10.5-2.0-3.1-1.3-1.2-1.3
Delta time in closed arm before/after self-admin0.10.10.5-0.0-0.10.50.2-0.3-0.1-0.7-0.30.5-0.40.30.2
Delta time in open arm before/after self-admin0.40.41.4-0.6-0.5-0.5-0.5-0.7-1.10.3-0.2-1.2-0.10.50.4
Diff in mean of infusions in LGA sessions1.11.32.71.41.60.91.21.10.9-0.41.41.21.70.60.7
Delay discount exponential model param2.42.65.0-2.2-2.2-1.9-2.1-1.5-1.40.2-1.6-1.6-1.5-1.1-1.0
Extinction: sum of active levers before priming0.30.30.8-0.1-0.10.70.1-0.5-0.7-0.90.20.7-0.10.80.6
Active lever presses in extinction session 61.01.02.9-1.7-1.5-1.1-1.4-0.8-1.30.2-0.8-0.0-0.0-0.2-0.7
Bone: final force1.01.66.50.90.3-1.30.21.61.32.51.0-0.70.9-1.3-1.2
Bone: final moment1.21.97.90.60.1-1.6-0.01.61.42.80.7-0.90.8-1.7-1.6
Food consumed during 24 hour testing period0.20.30.90.2-0.2-0.6-0.40.40.60.80.30.2-0.0-0.8-0.9
Glucose1.42.15.1-2.0-1.8-0.9-1.6-2.2-1.9-0.9-1.4-1.0-1.50.0-0.1
Heart weight1.52.45.4-2.1-1.9-2.3-2.2-0.6-0.80.9-1.1-0.8-0.6-1.7-1.8
Delay discount hyperbolic model param1.92.14.0-2.0-1.9-1.7-1.8-1.2-1.10.3-1.5-1.4-1.4-1.1-1.0
Intermittent access intake day 1-15 change0.51.12.6-1.3-1.5-1.4-1.6-0.9-1.00.1-0.4-0.9-0.7-0.8-0.6
Intermittent access intake escalation0.30.61.8-0.9-1.2-1.0-1.4-0.8-0.9-0.1-0.2-0.5-0.5-0.5-0.2
Intermittent access intake escalation 20.30.31.0-0.6-0.9-0.5-1.0-0.6-0.8-0.20.0-0.5-0.3-0.20.1
Intermitt. access day 1 inactive lever presses0.72.55.6-1.6-1.8-1.3-2.2-1.5-0.40.5-1.8-1.8-2.4-1.3-1.1
Intermitt. access day 15 inactive lever presses2.34.79.3-2.8-2.7-1.2-2.7-2.7-1.9-0.8-2.7-2.2-3.1-0.4-0.4
Intermitt. access escalation Index0.81.13.0-1.2-0.9-1.7-1.0-0.4-0.61.0-0.9-1.7-0.4-1.0-0.7
Intermittent access day 1 total infusions0.40.71.5-1.0-0.8-1.2-1.10.00.20.7-0.9-0.4-0.2-1.2-1.2
Intermittent access day 15 total infusions1.01.43.5-1.7-1.5-1.5-1.9-1.0-0.80.1-1.2-0.9-0.9-1.0-0.7
Intermittent access terminal intake (last 3 days)0.81.12.7-1.7-1.3-1.1-1.6-1.0-1.0-0.3-1.2-0.6-0.7-0.5-0.3
Intermittent access total infusions1.01.22.8-1.7-1.5-1.0-1.7-1.2-1.3-0.4-1.0-0.6-0.7-0.3-0.1
Intermittent access day 1 locomotion0.10.10.30.30.4-0.4-0.20.30.40.40.50.20.5-0.4-0.1
Intermittent access day 15 total locomotion0.50.92.5-1.1-1.2-1.3-1.6-1.2-1.0-0.0-0.4-0.6-0.6-0.5-0.4
Intermittent access total locomotion0.10.10.4-0.0-0.1-0.4-0.6-0.3-0.3-0.00.6-0.30.2-0.00.2
Intermittent access standard deviation0.10.31.00.2-0.10.4-0.4-0.2-0.6-0.71.00.50.40.50.7
Left kidney weight0.94.18.6-2.5-2.5-2.9-2.9-1.8-1.80.8-1.1-2.4-1.0-1.5-1.5
Right kidney weight0.52.36.3-1.8-1.9-1.8-2.5-1.8-1.70.2-0.6-1.7-1.1-0.7-0.4
Cocaine induced anxiety0.50.62.1-0.8-0.7-0.9-0.8-0.3-0.20.7-0.6-1.4-0.5-0.7-1.1
Post-drug Anxiety0.70.71.8-0.7-0.6-1.1-0.40.40.31.2-0.7-1.1-0.0-1.0-1.3
Baseline Anxiety0.30.30.90.50.50.51.00.4-0.0-0.30.50.40.90.70.7
Tail length0.41.64.8-0.7-1.2-2.2-0.80.60.42.1-0.2-0.80.1-1.9-1.8
Length with tail1.46.115.6-2.7-3.1-3.9-2.7-0.8-0.82.3-1.9-2.5-1.4-2.9-2.5
Length without tail1.96.112.3-2.9-3.0-3.5-3.0-1.5-0.91.5-2.4-2.8-1.9-2.6-2.2
Times rat made contact with spout1.71.96.0-1.3-1.3-0.4-1.6-2.4-2.5-1.30.0-0.9-0.61.21.1
Lifetime Intake0.70.92.1-1.4-1.3-0.7-1.5-1.2-1.3-0.6-0.7-0.4-0.6-0.1-0.1
Liver weight, left1.83.06.4-1.8-2.0-2.5-1.7-0.5-0.31.7-1.8-1.9-1.3-2.0-2.1
Liver weight, right1.62.77.3-1.5-1.9-2.7-1.7-0.3-0.22.0-0.8-1.5-0.6-2.2-2.1
Locomotor activity0.91.43.70.70.51.40.8-0.7-1.2-1.21.31.20.71.91.8
Locomotor testing distance0.91.53.70.90.81.60.8-0.6-1.0-1.41.41.10.71.91.8
Locomotor testing rearing0.81.73.70.1-0.11.20.1-1.5-1.9-1.81.20.90.31.91.9
Locomotion in novel chamber2.33.06.6-1.4-1.5-2.1-1.50.10.62.0-1.6-1.7-1.5-2.6-2.4
Locomotion in novel chamber post-restriction0.20.41.20.1-0.3-0.3-0.40.60.60.9-0.3-0.8-0.7-0.6-1.1
Fecal boli incidents, locomotor time 10.40.62.0-0.0-0.6-0.6-0.10.70.71.4-0.1-0.7-0.7-1.2-1.1
Change in fecal boli incidents, locomotor task1.00.92.8-1.0-0.50.3-0.9-1.7-1.2-1.3-1.2-0.2-1.00.70.5
Time >=10cm from walls, locomotor time 10.91.02.6-1.2-0.80.3-0.9-1.5-0.6-0.9-1.6-0.1-1.60.20.5
Bouts of movement, locomotor time 10.70.82.21.50.81.20.90.60.70.11.40.70.20.61.0
Total resting periods, locomotor time 10.50.61.81.30.60.90.60.80.90.51.20.50.10.10.5
Rest time, locomotor task time 10.10.10.40.1-0.50.1-0.3-0.00.10.30.40.5-0.7-0.20.0
Distance moved, locomotor task time 11.42.25.31.82.31.71.71.00.9-0.91.41.01.71.31.1
Vertical activity count, locomotor time 10.10.20.8-0.20.0-0.4-0.5-0.7-0.3-0.3-0.2-0.9-0.2-0.00.2
Time >=10cm from walls, locomotor time 20.71.12.7-1.5-1.4-0.6-1.2-1.6-1.4-0.9-0.80.1-0.80.10.4
Bouts of movement, locomotor time 21.42.35.31.01.01.81.1-0.2-1.1-1.61.81.41.42.32.1
Total resting periods, locomotor time 21.01.84.80.50.61.60.7-0.6-1.3-1.61.21.31.02.22.0
Rest time, locomotor task time 20.10.20.9-0.4-0.20.60.20.20.2-0.3-0.61.0-0.10.10.3
Distance moved, locomotor task time 21.61.95.32.11.81.21.40.90.7-0.32.31.31.50.90.7
Vertical activity count, locomotor time 20.20.31.20.70.50.20.2-0.5-0.3-0.31.10.20.30.50.5
Light reinforcement 10.61.52.7-1.3-1.6-1.3-1.3-0.30.01.0-1.3-0.8-1.5-1.4-1.6
Light reinforcement 20.71.02.9-1.6-1.7-1.2-0.9-0.4-1.00.5-0.9-0.5-1.0-0.8-0.7
Bone: marrow area2.24.89.0-2.5-3.0-2.9-2.9-2.1-1.51.3-1.3-2.2-2.2-2.0-1.5
Bone: maximum diameter1.42.76.0-1.4-1.7-2.5-1.5-0.20.31.9-1.3-1.6-1.2-2.3-1.9
Bone: maximum force1.12.08.50.6-0.1-1.8-0.31.31.32.90.8-1.10.5-1.8-1.6
Bone: maximum moment1.42.510.00.4-0.2-2.1-0.51.41.53.20.5-1.20.4-2.2-2.1
Mean time between licks in bursts0.20.61.8-0.2-0.3-0.9-0.10.50.71.1-0.7-0.5-0.4-1.3-1.1
Mean num. licks in bursts1.92.97.2-2.1-1.9-1.3-2.5-2.7-2.0-0.8-1.1-2.0-1.6-0.20.2
Cd content in liver0.40.51.3-0.0-0.1-0.20.30.31.00.8-0.90.1-0.8-0.9-1.1
Co content in liver0.10.10.60.30.1-0.30.20.30.50.80.3-0.1-0.1-0.5-0.2
Cu content in liver0.60.71.70.90.80.41.01.31.30.50.51.00.6-0.4-0.5
Fe content in liver0.40.51.1-0.00.00.3-0.2-0.4-0.9-1.00.90.80.80.80.9
K content in liver4.54.310.52.32.20.31.83.22.51.92.31.92.8-0.6-0.8
Mg content in liver0.70.81.90.70.8-0.20.91.40.91.20.70.81.3-0.5-0.3
Mn content in liver0.91.04.0-0.2-0.5-1.4-0.10.50.42.0-0.3-1.3-0.3-1.4-1.3
Na content in liver0.60.72.70.10.3-1.0-0.50.80.30.91.30.61.6-0.6-0.2
Rb content in liver0.10.10.8-0.4-0.10.1-0.10.10.5-0.3-0.90.5-0.3-0.4-0.2
Se content in liver0.20.30.70.50.80.40.60.60.7-0.00.10.70.80.20.4
Sr content in liver0.70.61.5-0.4-0.5-1.0-0.50.30.61.2-0.6-0.9-0.7-1.2-1.0
Zn content in liver0.40.40.90.70.70.10.30.80.80.40.91.00.7-0.30.2
Bone: minimum diameter1.32.48.1-0.4-0.8-2.6-1.00.60.62.80.1-1.40.1-2.2-2.1
Time in familiar zone, hab. session 10.40.41.00.90.90.5-0.1-0.30.0-0.51.0-0.40.40.90.9
Time in novel zone, hab. session 10.40.41.6-0.6-0.70.30.2-0.8-1.3-0.7-0.30.2-0.40.60.3
Total zone transitions, hab. session 10.81.13.61.31.11.20.50.50.2-0.81.90.90.81.01.1
Total locomotion distance, hab. session 11.92.77.82.21.71.91.20.70.2-1.22.81.21.31.71.7
Locomotion velocity, hab. session 11.01.44.31.81.51.10.91.20.9-0.32.10.91.10.60.8
Time in familiar zone, hab. session 21.31.43.9-0.4-0.50.8-0.7-2.0-1.8-1.80.3-0.4-0.81.51.3
Time in novel zone, hab. session 20.30.40.9-0.4-0.3-0.80.10.50.41.0-0.6-0.00.1-0.9-0.8
Total zone transitions, hab. session 20.50.71.9-0.4-1.0-0.9-1.4-0.7-0.70.40.6-1.2-0.7-0.5-0.6
Total locomotion distance, hab. session 21.41.84.5-1.1-1.8-1.5-2.1-1.5-1.20.40.2-1.7-1.5-0.9-1.0
Locomotion velocity, hab. session 21.01.33.4-0.6-1.4-1.4-1.9-1.0-0.70.60.5-1.6-1.2-0.9-1.0
Novel to familiar place preference ratio0.10.10.30.20.10.10.60.50.50.2-0.30.1-0.1-0.1-0.2
Novelty place preference0.20.20.60.50.30.20.80.80.60.4-0.10.10.1-0.1-0.1
Time in novel zone, NPP test0.10.10.30.2-0.00.00.60.40.20.2-0.10.2-0.0-0.0-0.1
Total zone transitions, NPP test0.30.41.00.40.0-0.5-0.40.70.70.71.00.00.2-0.8-0.8
Total locomotion distance, NPP test0.71.02.3-0.4-1.1-1.2-1.5-0.4-0.00.80.3-1.3-1.1-1.2-1.1
Locomotion velocity, NPP test0.70.91.9-0.0-0.7-1.2-1.20.00.41.20.5-1.4-0.9-1.4-1.2
Intraocular pressure0.40.51.60.40.10.10.60.31.00.8-0.6-0.9-1.3-0.8-0.7
Delta distance traveled before/after self-admin0.40.41.00.10.4-0.30.70.90.81.0-0.40.30.4-0.8-0.8
Delta ambulatory time before/after self-admin0.20.31.10.20.40.21.00.90.60.4-0.40.60.4-0.3-0.2
Parametrial fat weight3.88.925.3-4.4-4.0-2.4-3.1-4.1-5.0-1.7-2.1-2.0-0.90.71.0
Pavlov. Cond. lever latency3.24.010.7-2.3-2.00.4-1.0-2.9-3.3-2.6-1.8-0.9-1.81.51.5
Pavlov. Cond. magazine entry latency0.60.72.00.90.90.10.71.10.90.80.90.91.4-0.1-0.5
Pavlov. Cond. change in total contacts3.63.811.12.32.20.21.72.93.32.41.11.11.6-1.1-1.2
Pavlov. Cond. index score2.63.36.72.22.00.11.32.62.62.01.81.12.2-0.8-1.0
Pavlov. Cond. latency score3.03.88.22.52.20.01.42.82.92.22.01.02.1-0.9-1.0
Pavlov. Cond. lever contacts2.73.37.82.21.8-0.40.92.52.82.31.90.91.8-1.3-1.3
Pavlov. Cond. magazine entry number1.11.42.8-1.3-1.2-0.1-1.1-1.7-1.5-1.3-1.1-1.1-1.70.40.7
Pavlov. Cond. intertrial magazine entries2.02.54.0-1.3-2.0-2.0-1.5-0.6-0.41.7-1.0-1.9-1.8-1.8-1.6
Pavlov. Cond. lever-magazine prob. diff.2.93.67.32.32.20.11.32.72.72.12.01.22.4-0.7-1.0
Pavlov. Cond. response bias2.02.45.81.51.5-0.31.02.32.42.01.11.11.8-1.1-1.4
Pavlov. Cond. lever latency0.60.81.81.01.11.31.01.01.1-0.40.41.30.30.30.3
Pavlov. Cond. magazine entry latency3.64.47.8-2.7-2.8-1.6-2.4-2.8-2.3-0.4-2.1-2.3-2.4-0.4-0.5
Pavlov. Cond. change in total contacts1.21.93.4-1.8-1.7-1.8-1.8-1.8-1.80.3-0.6-1.5-0.5-0.5-0.2
Pavlov. Cond. index score2.12.85.5-2.2-2.2-1.6-1.9-2.3-2.2-0.3-1.5-1.8-1.4-0.2-0.1
Pavlov. Cond. latency score1.41.84.3-1.8-1.6-1.0-1.4-2.1-1.9-0.6-1.2-1.5-1.10.20.2
Pavlov. Cond. lever contacts1.01.42.6-1.4-1.5-1.6-1.4-1.4-1.40.3-0.6-1.5-0.6-0.5-0.4
Pavlov. Cond. magazine entry number2.42.95.32.22.31.82.22.21.90.01.32.01.50.50.5
Pavlov. Cond. intertrial magazine entries1.11.74.32.11.70.61.51.81.81.21.30.11.1-0.1-0.4
Pavlov. Cond. lever-magazine prob. diff.1.82.45.1-2.1-2.0-1.4-1.7-2.3-2.2-0.5-1.2-1.6-1.1-0.00.1
Pavlov. Cond. response bias2.43.25.7-2.3-2.4-2.3-2.1-1.8-1.70.7-1.5-2.3-1.4-1.1-1.1
Time in closed arm before self-admin0.60.71.6-0.7-0.4-0.9-0.60.00.50.9-1.3-1.0-0.8-1.0-1.1
Time in closed arm after self-admin0.50.51.3-0.5-0.5-0.6-0.4-0.10.50.6-1.1-0.2-1.0-1.0-1.0
Time in open arm before self-admin1.01.13.30.10.21.00.1-0.8-1.2-1.81.01.10.71.31.5
Time in open arm after self-admin0.70.82.10.00.40.50.2-0.4-1.3-1.01.00.31.31.51.4
Bone: periosteal estimation1.43.18.6-1.3-1.8-2.9-2.0-0.4-0.22.4-0.5-1.8-0.9-2.3-1.8
Bone: periosteal perimeter1.01.74.7-0.7-1.3-2.2-1.20.10.02.1-0.0-1.3-0.4-1.8-1.6
Bone: post-yield work0.10.20.3-0.1-0.6-0.5-0.6-0.4-0.20.30.3-0.5-0.5-0.5-0.2
Progressive ratio test 1 active lever presses0.40.51.2-0.9-0.70.0-0.7-0.9-1.1-1.1-0.00.80.20.40.4
Progressive ratio test 1 breakpoint0.30.41.0-0.9-0.7-0.0-0.6-0.7-1.0-0.9-0.00.80.20.30.4
Progressive ratio test 1 inactive lever presses0.91.23.1-1.5-1.8-0.5-1.2-1.4-1.0-0.7-1.2-0.5-1.6-0.3-0.4
Progressive ratio test 2 active lever presses0.50.61.9-1.0-1.1-1.2-1.4-0.4-0.40.3-0.4-0.3-0.4-0.8-0.5
Progressive ratio test 2 breakpoint0.60.72.2-1.1-1.2-1.3-1.5-0.4-0.40.4-0.4-0.5-0.4-0.9-0.6
Progressive ratio test 2 inactive lever presses2.33.77.3-2.4-2.7-2.4-2.5-1.4-1.40.9-1.6-2.2-1.8-1.6-1.3
Incentive Sensitization - Responses1.72.45.7-1.4-1.7-2.4-2.0-0.3-0.21.8-0.9-1.9-1.1-1.9-1.6
Incentive Sensitization - Breakpoint2.12.76.2-1.6-1.9-2.5-2.2-0.5-0.41.6-1.0-2.0-1.2-1.9-1.6
Sum of active levers in priming session hrs 5-61.41.33.50.20.31.91.1-0.2-0.6-1.70.11.80.31.61.0
Progressive ratio0.81.32.9-0.5-0.61.30.2-1.5-1.4-1.6-0.30.9-1.11.21.7
Food seeking constrained by brief footshock4.04.89.42.32.33.11.90.1-0.6-2.42.71.21.83.02.7
Seeking ratio, punishment vs. effort0.81.23.31.41.50.60.60.60.1-0.61.8-0.51.81.20.5
Retroperitoneal fat weight3.514.733.8-5.8-5.0-4.7-4.8-4.5-4.9-0.5-3.5-3.6-1.5-0.7-0.8
Reaction time number correct0.30.62.50.80.31.41.60.50.1-0.50.31.1-0.10.50.4
Reaction time mean minus median0.92.35.6-2.0-1.8-0.7-1.9-2.4-2.2-1.3-1.1-0.6-1.10.50.8
Reaction time mean minus median AUC1.12.75.7-2.3-2.2-1.0-2.0-2.4-2.2-0.9-1.5-1.0-1.40.20.3
Reaction time num false alarms0.30.52.20.50.60.20.41.11.50.5-0.40.1-0.2-0.7-0.6
Reaction time num false alarms AUC0.30.41.60.70.80.70.71.01.3-0.0-0.20.3-0.0-0.1-0.1
Reaction time trials correct on left0.30.62.50.80.31.41.60.50.1-0.50.31.1-0.10.50.4
Reaction time trials on left0.20.52.00.60.11.31.40.3-0.0-0.50.10.9-0.30.40.4
Reaction time mean2.94.712.2-2.8-2.4-0.7-2.6-3.5-3.0-2.1-1.7-1.0-1.90.71.2
Reaction time mean AUC2.53.910.9-2.4-2.0-0.6-2.4-3.3-2.8-1.9-1.4-1.1-1.60.91.4
Median of all reaction times2.73.910.4-2.5-2.1-0.6-2.4-3.2-2.7-2.0-1.6-1.0-1.80.71.1
Reaction time omissions3.65.310.1-3.2-2.9-2.0-3.2-2.6-1.8-0.2-2.8-2.2-2.6-1.2-0.4
Reaction time false alarm rate0.20.31.10.00.3-0.4-0.40.51.10.5-0.5-0.5-0.3-0.6-0.5
Reaction time premature initiation rate0.10.20.50.60.40.20.70.60.60.50.1-0.10.10.0-0.2
Reaction time premature initiations0.30.52.31.00.61.01.50.80.60.00.30.50.10.30.1
Std. dev. reaction times2.13.99.0-2.6-2.3-1.1-2.6-3.0-2.4-1.4-1.8-1.4-1.90.30.8
Reaction time trials completed0.20.52.00.60.11.31.40.3-0.0-0.50.10.9-0.30.40.4
Reaction time trials AUC0.20.31.30.3-0.21.01.10.2-0.1-0.4-0.10.6-0.60.10.1
Run reversals in cocaine runway, females1.11.12.9-0.8-1.2-1.7-1.5-0.9-1.10.80.6-1.30.2-0.9-0.7
Run reversals in cocaine runway, males0.50.52.40.80.7-0.20.31.00.60.71.0-0.11.6-0.00.1
Latency to leave start box in cocaine runway0.80.91.7-1.3-1.1-0.5-1.0-1.3-1.0-0.4-1.3-0.5-1.3-0.2-0.2
Latency to leave start box in cocaine runway, F1.01.12.2-1.5-1.4-0.7-1.2-1.3-0.9-0.4-1.4-0.3-1.5-0.4-0.4
Latency to leave start box in cocaine runway, M0.50.51.5-0.8-0.5-0.7-0.7-0.4-0.50.4-0.8-1.2-0.7-0.4-0.5
Std. dev. time between licks in bursts0.81.13.41.00.6-0.50.81.41.51.80.3-0.50.2-1.1-1.1
Total sessions with >9 infusions0.50.62.1-0.8-0.9-0.1-0.7-1.1-1.5-1.00.30.80.20.50.4
Short access day 1 total inactive lever presses2.12.86.2-2.1-2.3-1.2-2.2-1.9-1.2-0.1-1.9-1.2-2.5-0.9-0.9
Short access day 10 total inactive lever presses1.84.411.1-2.6-2.8-1.1-2.3-2.8-1.9-0.5-2.6-1.3-3.3-0.5-0.2
Short access day 1 total infusions0.10.20.4-0.1-0.30.4-0.2-0.5-0.4-0.60.30.6-0.40.30.2
Short access day 10 total infusions0.60.71.8-1.1-1.00.2-0.6-1.2-1.4-1.2-0.50.7-0.40.60.3
Short access total infusions0.60.82.2-1.1-1.1-0.1-1.0-1.3-1.5-1.0-0.20.2-0.30.60.4
Short access day 1 locomotion0.20.31.0-0.5-0.5-0.2-0.5-0.7-1.0-0.80.30.30.20.30.4
Short access day 10 total locomotion0.20.41.0-0.1-0.6-0.8-0.6-0.10.40.8-0.0-0.1-0.6-1.0-0.9
Short access total locomotion0.10.10.60.20.0-0.3-0.20.1-0.00.30.70.60.6-0.2-0.1
One hour access (0.3 mA shock)0.70.82.1-1.0-1.1-0.4-1.5-1.3-1.4-0.7-0.0-0.5-0.80.20.6
Compulsive drug intake0.20.20.50.60.2-0.1-0.3-0.30.30.40.7-0.7-0.5-0.10.3
One hour access (shock baseline)0.30.51.3-0.8-0.60.0-0.9-0.9-1.1-1.1-0.30.1-0.20.60.4
Social response proportion1.11.24.8-0.8-0.50.20.0-1.6-2.2-1.20.1-0.00.51.51.6
Social responses0.81.12.21.00.91.41.50.2-0.3-0.70.91.10.91.51.1
Social time0.30.40.8-0.5-0.20.40.2-0.6-0.9-0.8-0.50.70.30.90.8
Soleus weight0.92.54.7-1.3-1.5-2.2-1.8-0.30.32.0-1.4-1.9-1.5-1.9-1.8
Bone: stiffness1.22.08.80.3-0.4-1.9-0.51.11.13.00.2-1.5-0.1-1.9-1.8
Tibialis anterior weight0.72.35.6-1.5-1.6-2.4-1.8-0.6-0.31.8-1.0-1.9-0.9-1.6-1.7
Time to tail flick, vehicle, before self-admin2.82.97.0-2.6-2.1-0.9-2.1-2.1-2.0-1.0-2.2-0.6-1.80.20.1
Time to tail flick, vehicle, after self-admin0.20.21.10.10.3-0.2-0.10.41.10.3-0.6-0.4-0.5-0.7-0.4
Time to tail flick, test, before self-admin0.40.41.20.20.40.90.3-0.4-0.3-1.10.30.40.00.91.0
Time to tail flick, test, after self-admin1.71.86.2-1.5-1.8-0.5-1.5-1.4-0.5-1.0-1.90.0-2.5-0.7-0.6
Delta time to tail flick, vehicle, before/after SA1.71.75.81.00.7-0.60.61.72.41.8-0.1-0.6-0.1-1.8-1.5
Delta time to tail flick, test, before/after SA1.31.32.8-1.2-1.5-1.2-1.4-0.6-0.10.4-1.3-0.8-1.7-1.3-1.1
Tibia length0.20.72.2-0.3-0.4-1.5-0.20.4-0.31.40.7-0.31.3-0.7-0.6
Ambulatory time before self-admin0.61.02.31.11.20.91.00.90.3-0.11.21.01.50.90.8
Ambulatory time after self-admin2.12.55.81.71.91.02.32.41.50.81.11.52.20.20.2
Bone: tissue strength0.60.63.31.00.3-0.40.10.1-0.31.01.8-0.60.90.20.0
Total heroin consumption1.51.84.2-1.7-1.50.1-1.2-2.0-2.1-1.4-1.1-0.3-1.30.80.7
Bone: trabecular number1.01.74.6-0.4-0.4-1.8-1.10.21.02.2-0.7-1.6-0.7-1.8-1.8
Bone: trabecular spacing0.81.13.5-0.10.41.21.00.1-0.4-1.9-0.31.60.91.21.3
Bone: trabecular thickness0.60.71.4-0.7-0.4-1.0-1.1-0.10.50.8-0.9-1.0-0.8-1.0-1.2
Bone: trabecular tissue density0.30.41.30.50.5-0.50.10.90.60.70.90.41.1-0.4-0.5
Water consumed over 24 hours0.50.62.0-0.6-1.1-0.3-1.1-1.4-1.2-0.30.2-0.4-1.00.30.1
Number of responses in last shaping day0.20.20.50.4-0.00.70.2-0.2-0.1-0.60.50.6-0.40.30.3