Slc24a3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Slc24a3	0.1	0.06	2.7e-03	0.02	0.05	0.01	0.04	4.9e-02	4.1e-03	7.4e-02	9.1e-03
2	RMTg	gene expression	Slc24a3	0.24	0.1	2.8e-05	0.13	0.22	0.14	0.15	2.8e-04	1.2e-06	1.2e-04	7.2e-05
3	Brain	gene expression	Slc24a3	0.25	0.09	1.6e-13	0.06	0.16	0.14	0.15	5.1e-06	6.0e-15	3.0e-13	1.0e-13
4	BLA	gene expression	Slc24a3	0.14	0.07	7.0e-06	0.1	0.1	0.08	0.09	8.1e-06	4.3e-06	2.8e-05	2.1e-05
5	PL	gene expression	Slc24a3	0.09	0.04	3.4e-09	0.05	0.07	0.06	0.06	5.9e-06	2.8e-08	3.0e-07	1.9e-07
6	Adipose	gene expression	Slc24a3	0.52	0.09	0.0e+00	0.24	0.3	0.28	0.28	3.7e-26	3.5e-33	3.7e-31	1.0e-31
7	Brain	mRNA stability	Slc24a3	0.05	0.03	1.1e-03	0.03	0	0.01	0.01	5.7e-04	1.3e-01	5.2e-02	1.7e-02
8	NAcc	gene expression	Slc24a3	0.04	0.03	3.5e-03	0	0.02	0.01	0	1.0e-01	2.7e-03	1.6e-02	1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	1.9	3.2	5.9	-1.2	-2.3	-1.7	-2.0	0.9	-1.7	2.4	-1.6
Area under the delay curve	2.4	2.6	4.2	2.1	1.8	1.8	1.9	1.1	1.6	-1.1	1.1
BMI with tail	1.1	3.6	7.5	-2.5	-2.7	-1.9	-1.9	-1.6	-1.9	1.0	0.8
BMI without tail	1.2	2.4	5.0	-2.2	-2.0	-1.5	-1.7	-2.1	-0.4	0.8	0.6
Body weight	2.7	11.2	27.1	-4.1	-5.2	-3.0	-4.2	-1.2	-2.8	3.2	0.1
Weight adjusted by age	3.7	4.2	6.3	-1.6	-2.5	-1.4	-2.5	1.3	-2.4	2.5	-1.8
Bone surface	1.5	2.6	5.7	-1.6	-2.4	-1.9	-2.0	-0.4	-1.2	1.7	-0.8
Bone volume	2.5	4.3	7.5	-1.8	-2.7	-2.0	-2.5	0.3	-1.9	2.5	-1.6
Breakpoint value in progressive ratio session	0.9	1.0	3.0	-0.2	1.2	0.3	0.9	-1.6	0.2	-1.7	0.6
Number of licking bursts	0.9	1.0	2.4	1.1	1.1	1.6	1.0	1.0	0.8	-0.3	0.9
Context. condit. distance diff. score	2.4	2.9	5.2	-1.6	-2.0	-1.5	-1.8	0.3	-2.3	2.3	-1.0
Locomotion velocity, session 1	0.3	0.4	1.5	0.2	0.5	0.1	0.2	-0.8	1.2	-0.6	0.3
Locomotion distance, session 1	0.9	1.1	2.5	1.4	1.6	0.8	1.3	0.7	1.1	-0.6	-0.1
Locomotion velocity, session 2	1.9	2.2	6.5	1.9	1.3	0.9	1.5	0.6	2.5	-1.2	0.9
Locomotion distance, session 2	0.4	0.6	2.6	0.5	0.5	0.1	0.1	0.4	1.6	-0.0	-1.1
Locomotion velocity, session 3	0.6	0.7	1.6	1.2	0.9	1.0	0.7	1.3	0.5	0.3	0.0
Locomotion distance, session 3	0.4	0.4	1.5	0.5	-0.0	0.2	0.1	1.2	-0.6	1.1	-0.1
Stereotopy head waving bouts, day 3	0.6	0.7	2.2	0.3	1.2	0.5	0.8	-1.0	0.6	-1.5	-0.1
Stereotopy head waving duration, day 3	0.3	0.4	1.0	0.2	0.7	0.6	0.3	-0.7	0.7	-1.0	0.2
Locomotion velocity, session 7	0.5	0.6	2.2	0.5	-0.2	0.6	-0.1	1.5	0.0	1.2	-0.3
Locomotion distance, session 7	0.8	1.0	3.5	-0.5	-0.5	-0.3	-0.6	0.9	-1.9	1.3	-1.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.1	-0.3	0.1	-0.3	-0.1	0.3	0.5	0.0
Stereotopy head waving duration, day 7	0.2	0.2	1.2	0.5	0.3	0.4	0.3	-0.1	1.1	-0.2	0.3
Locomotion velocity, session 8	0.1	0.1	0.2	-0.3	0.0	-0.3	-0.2	-0.5	0.1	0.2	-0.3
Locomotion distance, session 8	0.8	1.2	3.7	-0.4	-0.9	-0.7	-1.0	1.1	-0.8	1.9	-1.2
Degree of sensitization distance	0.6	0.6	1.7	-0.9	-0.2	-0.6	-0.6	-0.6	-1.3	-0.1	-1.1
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.2	-0.5	-0.1	-0.4	-0.2	0.2	0.5	0.1
Conditioned locomotion	0.4	0.5	1.1	-0.6	-0.6	0.2	-1.0	0.3	-1.0	0.7	-0.8
Cocaine response after cond. corrected	0.4	0.4	1.7	0.1	0.1	0.1	-0.2	0.9	-0.3	0.9	-1.3
Cocaine response after cond. not corrected	1.5	1.6	4.1	0.0	-0.8	-0.2	-1.0	1.8	-0.6	2.0	-1.9
Cocaine response before conditioning	0.7	0.8	1.6	-0.2	-1.3	-0.5	-1.1	1.2	-0.1	1.2	-0.8
Saline control response	3.1	4.0	7.0	-2.6	-1.7	-2.5	-2.2	-2.1	-1.3	0.6	-2.1
Bone: connectivity density	0.8	1.3	2.2	-0.8	-1.3	-1.5	-1.1	0.1	-1.3	1.2	-1.1
Bone: cortical apparent density	0.3	0.4	0.8	0.8	0.3	0.5	0.6	0.9	-0.3	0.2	0.8
Bone: cortical area	0.9	1.4	3.4	0.2	-1.8	0.2	-1.0	1.6	0.6	1.8	1.0
Bone: cortical porosity	0.9	1.0	2.2	0.4	0.7	0.6	0.8	-1.0	1.5	-1.3	1.2
Bone: cortical porosity	0.5	0.5	1.1	0.1	0.3	0.5	0.4	-0.8	1.0	-0.8	1.1
Bone: cortical thickness	1.1	1.8	5.0	1.1	-1.0	1.1	-0.1	1.8	1.4	1.0	2.2
Bone: cortical thickness	0.9	1.0	3.8	1.2	0.5	1.1	0.6	1.9	-0.7	0.5	0.3
Bone: cortical tissue density	0.2	0.2	0.5	0.6	0.3	0.3	0.5	0.7	-0.6	0.2	0.6
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	-0.1	-0.2	-0.1	-0.3	0.3	0.5	0.6	-0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.3	0.4	0.4	0.1	0.3	0.5	-0.1	-0.6
Condit. Reinf. active responses	0.2	0.2	0.7	0.1	-0.3	0.1	-0.3	0.6	0.8	0.7	-0.3
Condit. Reinf. inactive responses	0.2	0.3	1.1	0.4	0.3	0.5	0.3	0.1	1.0	-0.2	0.7
Incentive salience index mean	0.8	0.9	3.6	1.1	-0.0	0.5	0.4	1.3	1.9	0.7	0.4
Condit. Reinf. lever presses	1.8	2.4	7.2	1.9	0.2	1.1	1.0	1.9	2.7	0.4	1.6
Condit. Reinf. active minus inactive responses	1.2	1.5	4.6	-1.3	-2.2	-0.9	-1.8	-0.4	0.5	1.1	-0.1
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.9	-0.7	-0.8	-0.5	-0.7	-1.0	1.4	-0.1	0.1
Condit. Reinf. active responses	0.4	0.6	2.3	-0.3	-1.5	-0.0	-0.9	0.4	0.4	0.8	0.8
Condit. Reinf. inactive responses	0.5	0.6	1.7	0.7	-0.5	0.7	0.1	1.3	-0.5	0.5	1.2
Condit. Reinf. lever presses	2.0	2.7	5.6	-2.2	-2.4	-1.9	-2.0	-1.7	-0.6	0.7	-0.5
Condit. Reinf. lever reinforcers received	0.4	0.6	2.1	-0.5	-1.5	-0.2	-0.9	-0.2	0.7	0.5	0.8
Conditioned reinforcement - actives	1.1	1.1	3.0	-1.2	-0.5	-1.7	-0.8	-0.8	-0.3	0.5	-1.7
Conditioned reinforcement - inactives	0.4	0.4	1.6	-0.6	-0.1	-0.4	-0.6	0.4	-0.7	0.6	-1.3
Conditioned locomotion	0.4	0.5	1.4	0.2	0.6	-0.3	0.5	-0.8	1.2	-1.0	0.0
Patch foraging indifference point 0 sec	2.0	3.3	8.3	-1.7	-1.5	-1.0	-2.0	0.5	-2.9	1.8	-2.0
Patch foraging indifference point AUC	1.5	1.8	2.6	1.5	1.5	1.6	1.5	0.2	1.6	-1.2	1.0
Delay disc. indifference point, 0s delay	1.9	2.1	5.6	1.4	0.9	1.3	1.4	0.2	2.4	-1.4	1.6
Delay disc. indifference point, 16s delay	2.0	2.0	3.7	1.8	1.9	1.6	1.7	1.0	1.2	-1.1	0.4
Delay disc. indifference point, 2s delay	1.9	2.1	4.3	1.5	1.3	1.5	1.7	0.4	2.1	-1.1	1.5
Delay disc. indifference point, 24s delay	4.1	4.0	7.6	2.8	2.2	2.6	2.1	2.5	1.0	-0.1	0.7
Delay disc. indifference point, 4s delay	1.1	1.1	2.0	1.2	1.0	1.4	1.1	1.0	0.8	-0.8	1.0
Delay disc. indifference point, 8s delay	1.6	1.6	2.5	1.6	1.5	1.5	1.5	0.7	1.2	-1.0	0.9
Indifference point function ln k	1.5	2.0	3.6	-1.4	-1.2	-1.5	-1.5	0.1	-1.9	1.2	-1.8
Indifference point function log k	1.5	2.0	3.6	-1.4	-1.2	-1.5	-1.5	0.1	-1.9	1.2	-1.8
Patch foraging total patch changes 0 sec	1.8	2.8	6.3	-1.5	-1.5	-0.9	-2.0	0.6	-2.5	1.8	-1.9
Patch foraging total patch changes 12 sec	0.2	0.3	0.9	-0.1	-0.5	0.3	-0.3	0.7	-0.9	0.8	0.3
Patch foraging total patch changes 18 sec	0.4	0.6	1.5	-0.2	-0.2	0.3	-0.6	0.8	-1.2	1.0	-0.9
Patch foraging total patch changes 24 sec	0.1	0.1	0.4	0.1	-0.3	0.4	-0.4	0.6	0.4	0.5	-0.0
Patch foraging total patch changes 6 sec	0.4	0.6	1.4	-0.3	-0.7	0.2	-0.9	1.1	-0.9	1.2	-0.7
Patch foraging time to switch 0 sec	0.2	0.3	1.7	0.0	-0.3	0.0	0.2	-0.2	0.7	0.1	1.3
Patch foraging water rate 0 sec	0.3	0.4	1.3	0.8	0.6	0.8	0.2	1.1	-0.2	-0.0	-0.6
Patch foraging water rate 12 sec	1.1	1.7	7.6	1.7	0.3	1.5	0.5	2.8	0.3	0.7	-0.3
Patch foraging water rate 18 sec	1.6	2.1	7.5	1.7	1.3	1.6	0.7	2.7	0.1	0.6	-1.3
Patch foraging water rate 24 sec	0.8	1.1	2.5	0.9	1.4	1.6	0.6	1.3	-0.7	-0.1	-1.1
Patch foraging water rate 6 sec	0.9	1.2	5.3	1.2	0.5	1.2	0.2	2.3	-0.4	0.9	-0.7
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	2.1	0.2	1.2	0.2	1.1	-1.5	1.0	-1.3	0.5
Distance traveled before self-admin	1.1	1.2	1.7	1.0	1.1	0.9	1.3	0.1	1.3	-1.2	1.2
Distance traveled after self-admin	2.4	2.7	5.6	1.7	1.3	2.2	1.6	0.6	1.5	-1.0	2.4
Extensor digitorum longus weight	0.7	2.9	5.7	-1.8	-2.4	-2.0	-2.0	-0.1	-1.2	2.1	-0.8
Bone: elastic displacement	1.1	1.2	2.3	0.9	1.1	0.9	1.3	-0.4	0.8	-1.4	1.5
Bone: elastic work	0.5	0.6	3.1	0.3	-0.2	0.5	0.4	-0.4	1.1	-0.4	1.7
Bone: endosteal estimation	2.3	5.1	8.2	-2.8	-2.7	-2.9	-2.6	-1.5	-1.0	1.8	-2.1
Bone: endosteal perimeter	1.8	3.7	5.2	-2.2	-2.3	-2.1	-2.3	-0.8	-1.3	1.9	-2.0
Epididymis fat weight	1.7	3.9	8.7	-2.6	-3.0	-2.3	-2.3	-1.3	-1.5	1.2	-0.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.1	0.4	-0.0	0.1	-0.3	-0.4	-0.2	-0.4
Delta time in open arm before/after self-admin	0.2	0.2	0.7	-0.7	-0.4	-0.4	-0.4	-0.8	-0.1	-0.4	0.1
Diff in mean of infusions in LGA sessions	1.6	1.8	2.8	1.5	1.6	1.4	1.7	0.4	1.3	-1.3	0.9
Delay discount exponential model param	2.5	2.7	4.6	-2.1	-1.9	-1.9	-1.9	-1.3	-1.5	1.1	-1.0
Extinction: sum of active levers before priming	0.3	0.3	0.8	-0.3	0.7	-0.4	0.4	-0.9	-0.2	-0.9	-0.5
Active lever presses in extinction session 6	1.3	1.3	2.8	-1.7	-0.9	-1.2	-1.0	-1.4	-1.4	0.5	-0.2
Bone: final force	0.7	1.1	2.4	0.1	-1.4	0.4	-0.9	1.3	1.0	1.5	0.8
Bone: final moment	0.8	1.4	3.7	-0.0	-1.8	0.1	-1.1	1.4	0.7	1.9	0.6
Food consumed during 24 hour testing period	0.2	0.2	0.8	0.0	-0.5	-0.2	-0.1	0.5	0.3	0.9	-0.1
Glucose	1.4	2.1	3.9	-1.8	-0.8	-2.0	-1.1	-1.6	-1.6	-0.1	-1.7
Heart weight	0.7	1.0	2.1	-1.5	-1.1	-1.1	-0.9	-1.2	-1.1	0.3	-0.2
Delay discount hyperbolic model param	2.4	2.5	4.1	-2.0	-1.8	-1.8	-1.9	-1.1	-1.5	1.1	-1.0
Intermittent access intake day 1-15 change	1.7	1.7	3.8	-1.7	-1.3	-2.0	-1.3	-1.4	-0.7	0.5	-1.0
Intermittent access intake escalation	1.1	1.1	2.6	-1.4	-0.9	-1.6	-1.0	-1.1	-0.4	0.3	-1.0
Intermittent access intake escalation 2	1.2	1.2	2.9	-1.5	-0.7	-1.7	-0.8	-1.4	-0.5	0.2	-1.0
Intermitt. access day 1 inactive lever presses	1.2	1.3	2.6	-0.9	-1.1	-1.5	-1.2	0.3	-1.1	1.0	-1.6
Intermitt. access day 15 inactive lever presses	3.6	4.0	6.7	-2.3	-1.2	-2.6	-1.7	-1.3	-2.6	0.9	-2.5
Intermitt. access escalation Index	3.9	3.4	6.5	-2.3	-2.5	-1.9	-2.5	-1.3	-1.6	1.1	-0.7
Intermittent access day 1 total infusions	0.4	0.4	1.2	-0.4	-0.9	-0.7	-0.5	0.1	-0.5	1.1	0.2
Intermittent access day 15 total infusions	1.2	1.3	2.8	-1.4	-1.2	-1.7	-1.0	-0.9	-1.1	0.8	-0.7
Intermittent access terminal intake (last 3 days)	0.8	0.9	2.3	-1.1	-0.9	-1.5	-0.7	-1.0	-1.0	0.5	-0.3
Intermittent access total infusions	0.8	0.9	2.1	-1.2	-0.9	-1.4	-0.7	-1.2	-0.8	0.4	-0.3
Intermittent access day 1 locomotion	0.3	0.3	1.0	0.5	-0.3	-0.0	0.3	0.1	0.9	-0.1	1.0
Intermittent access day 15 total locomotion	0.6	0.6	1.7	-0.9	-1.0	-1.3	-0.8	-0.6	-0.2	0.3	-0.6
Intermittent access total locomotion	0.2	0.2	0.9	0.4	0.0	-0.2	0.4	-0.2	1.0	-0.4	0.6
Intermittent access standard deviation	0.3	0.3	0.8	-0.3	0.5	-0.6	0.3	-0.9	0.8	-0.5	-0.4
Left kidney weight	0.5	1.3	2.7	-1.5	-1.6	-1.4	-1.4	-1.1	-0.1	0.7	-0.1
Right kidney weight	0.4	1.0	2.4	-1.4	-0.9	-1.4	-0.9	-1.6	-0.3	-0.3	-0.3
Cocaine induced anxiety	0.2	0.2	0.6	-0.5	-0.0	-0.3	-0.4	-0.4	-0.8	0.2	-0.6
Post-drug Anxiety	1.0	1.2	2.2	-1.5	-1.0	-1.0	-1.2	-0.8	-1.4	0.9	-0.5
Baseline Anxiety	0.7	0.8	1.9	-1.3	-0.6	-1.1	-0.6	-1.4	-0.8	-0.0	-0.3
Tail length	0.3	1.0	2.0	-1.3	-1.4	-0.5	-1.4	-0.2	-0.3	1.3	-0.2
Length with tail	1.4	5.1	12.5	-2.5	-3.5	-1.7	-3.2	0.0	-1.2	2.7	-0.5
Length without tail	1.4	3.0	8.0	-1.7	-2.8	-1.6	-2.3	0.3	-1.2	1.8	-0.4
Times rat made contact with spout	1.2	1.3	5.5	-1.3	-0.3	-1.4	-0.3	-2.3	-0.3	-1.0	-0.2
Lifetime Intake	0.6	0.6	1.7	-1.1	-0.4	-1.2	-0.5	-1.3	-0.6	0.1	-0.4
Liver weight, left	1.9	3.1	9.2	-1.1	-2.5	-1.3	-1.9	1.2	-1.2	3.0	-0.3
Liver weight, right	1.8	3.0	10.4	-0.5	-2.5	-0.8	-1.7	1.9	-0.5	3.2	0.3
Locomotor activity	0.8	1.3	3.6	0.4	1.3	0.7	1.0	-1.1	1.3	-1.9	0.7
Locomotor testing distance	0.7	1.2	3.8	0.6	1.4	0.6	1.1	-0.9	1.1	-1.9	0.3
Locomotor testing rearing	0.8	1.2	3.6	-0.1	1.1	0.0	0.9	-1.8	1.0	-1.9	0.1
Locomotion in novel chamber	3.8	4.7	7.1	-1.9	-2.6	-1.9	-2.7	0.5	-2.2	2.6	-2.0
Locomotion in novel chamber post-restriction	0.2	0.2	0.5	0.1	0.1	0.0	-0.3	0.6	-0.1	0.7	-0.7
Fecal boli incidents, locomotor time 1	0.3	0.3	0.8	-0.1	-0.2	0.1	-0.5	0.9	0.0	0.9	-0.8
Change in fecal boli incidents, locomotor task	0.5	0.5	1.4	-0.6	0.2	-0.7	-0.1	-1.1	-1.2	-0.3	-0.5
Time >=10cm from walls, locomotor time 1	0.7	0.7	2.5	-0.6	0.3	-0.7	-0.1	-0.5	-1.6	-0.3	-1.4
Bouts of movement, locomotor time 1	0.9	1.0	2.1	1.0	1.4	0.9	1.0	0.5	1.5	-0.9	-0.4
Total resting periods, locomotor time 1	0.6	0.7	1.8	0.9	1.1	0.6	0.7	0.8	1.4	-0.4	-0.5
Rest time, locomotor task time 1	0.2	0.2	0.5	0.1	0.5	0.0	0.3	0.3	0.7	0.2	-0.7
Distance moved, locomotor task time 1	2.6	2.8	5.3	2.3	1.6	1.9	2.0	1.1	1.4	-1.1	1.8
Vertical activity count, locomotor time 1	0.1	0.1	0.3	-0.1	-0.5	-0.5	-0.2	-0.1	-0.2	-0.1	-0.1
Time >=10cm from walls, locomotor time 2	0.7	0.7	2.2	-1.2	-0.6	-1.1	-0.5	-1.5	-0.5	-0.1	-0.4
Bouts of movement, locomotor time 2	1.9	2.1	4.5	0.8	1.6	0.9	1.5	-1.2	1.6	-2.1	1.3
Total resting periods, locomotor time 2	1.5	1.6	4.3	0.4	1.5	0.5	1.2	-1.4	1.1	-2.1	1.0
Rest time, locomotor task time 2	0.1	0.1	0.4	0.0	0.5	0.1	0.3	0.0	-0.6	-0.2	0.1
Distance moved, locomotor task time 2	1.8	2.1	5.7	1.7	1.2	1.4	1.6	0.7	2.4	-0.7	1.0
Vertical activity count, locomotor time 2	0.3	0.4	1.9	0.5	0.3	0.3	0.6	-0.2	1.4	-0.4	0.2
Light reinforcement 1	1.0	1.9	2.6	-1.5	-1.3	-1.5	-1.5	-0.0	-1.3	1.5	-1.6
Light reinforcement 2	1.1	1.5	3.1	-1.8	-1.2	-1.2	-1.5	-1.1	-0.9	0.7	-1.0
Bone: marrow area	2.4	5.3	8.6	-2.8	-2.8	-2.9	-2.6	-1.5	-1.0	1.8	-2.1
Bone: maximum diameter	1.5	2.8	5.4	-1.6	-2.3	-1.4	-2.1	0.3	-1.5	2.1	-1.2
Bone: maximum force	0.8	1.3	3.6	-0.2	-1.8	-0.1	-1.3	1.2	0.7	1.9	0.2
Bone: maximum moment	1.0	1.7	5.0	-0.3	-2.1	-0.2	-1.4	1.4	0.6	2.2	0.2
Mean time between licks in bursts	0.4	0.5	1.1	-0.2	-0.9	0.1	-0.9	0.9	-0.6	1.0	-0.3
Mean num. licks in bursts	2.1	2.5	6.0	-1.9	-1.4	-2.5	-1.3	-2.0	-1.1	-0.0	-1.2
Cd content in liver	0.2	0.2	0.7	0.4	0.1	0.6	0.3	0.8	0.3	0.1	0.1
Co content in liver	0.7	0.8	1.7	1.2	0.4	1.0	0.7	1.1	1.3	-0.4	0.7
Cu content in liver	0.2	0.3	0.5	0.5	0.5	0.7	0.4	0.7	0.3	0.6	0.1
Fe content in liver	0.2	0.3	0.7	-0.4	-0.3	-0.6	-0.2	-0.8	0.8	0.3	0.1
K content in liver	4.4	4.3	7.3	2.5	0.6	2.2	1.5	2.5	2.6	0.8	2.7
Mg content in liver	1.2	1.3	3.1	1.2	-0.0	1.1	0.6	1.4	1.1	0.8	1.8
Mn content in liver	0.7	0.8	2.4	0.1	-0.9	0.6	-1.1	1.3	0.1	1.6	-0.2
Na content in liver	1.4	1.5	5.2	0.9	-0.7	0.2	0.5	0.5	2.2	0.3	2.3
Rb content in liver	0.7	0.9	2.1	1.1	0.8	1.2	1.0	1.5	-0.3	0.4	0.6
Se content in liver	0.5	0.6	1.1	1.0	0.7	0.9	1.0	0.9	0.1	-0.2	0.9
Sr content in liver	0.7	0.6	1.1	-0.6	-1.1	-0.8	-1.0	0.4	-0.5	0.8	-0.9
Zn content in liver	0.1	0.1	0.2	0.1	-0.4	-0.4	-0.0	0.2	0.3	-0.0	0.1
Bone: minimum diameter	1.2	2.3	6.5	-1.0	-2.5	-0.9	-2.0	0.4	0.2	2.4	0.1
Time in familiar zone, hab. session 1	0.4	0.4	1.2	0.7	0.4	-0.1	0.7	0.0	1.1	-0.8	0.4
Time in novel zone, hab. session 1	0.4	0.4	1.3	-0.7	0.4	0.1	-0.3	-1.2	-0.6	-0.6	-0.5
Total zone transitions, hab. session 1	0.8	1.1	3.2	1.2	1.2	0.5	1.2	0.2	1.8	-0.9	0.5
Total locomotion distance, hab. session 1	2.0	2.9	7.1	1.9	2.0	1.4	1.9	0.3	2.7	-1.5	0.9
Locomotion velocity, hab. session 1	1.1	1.6	4.1	1.7	1.3	1.1	1.4	1.0	2.0	-0.4	0.7
Time in familiar zone, hab. session 2	0.9	1.0	3.3	-0.5	0.7	-1.0	0.2	-1.8	0.5	-1.4	-0.8
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.3	-0.8	0.2	-0.5	0.5	-0.8	0.8	0.1
Total zone transitions, hab. session 2	0.5	0.7	1.3	-0.9	-0.8	-1.1	-1.0	-0.6	0.5	0.5	-0.8
Total locomotion distance, hab. session 2	1.4	1.9	3.4	-1.6	-1.3	-1.8	-1.7	-1.1	0.1	0.9	-1.6
Locomotion velocity, hab. session 2	1.0	1.3	2.3	-1.1	-1.2	-1.5	-1.4	-0.6	0.4	1.0	-1.4
Novel to familiar place preference ratio	0.1	0.1	0.3	0.1	0.2	0.5	0.1	0.5	-0.3	0.3	-0.2
Novelty place preference	0.2	0.2	0.6	0.3	0.3	0.8	0.2	0.7	-0.1	0.2	0.0
Time in novel zone, NPP test	0.0	0.0	0.2	-0.0	0.1	0.5	0.0	0.3	-0.1	0.1	-0.1
Total zone transitions, NPP test	0.2	0.3	1.2	0.2	-0.5	-0.3	-0.2	0.6	1.1	0.9	0.0
Total locomotion distance, NPP test	0.7	1.0	1.8	-0.8	-1.0	-1.2	-1.2	0.1	0.2	1.3	-1.3
Locomotion velocity, NPP test	0.6	0.9	2.2	-0.4	-1.0	-0.9	-1.0	0.6	0.5	1.5	-1.1
Intraocular pressure	0.7	1.0	3.3	0.2	0.3	0.7	-0.4	1.4	-0.8	1.0	-1.8
Delta distance traveled before/after self-admin	0.6	0.7	1.9	0.8	-0.0	1.3	0.2	0.9	-0.1	0.6	1.4
Delta ambulatory time before/after self-admin	0.4	0.5	1.7	0.6	0.3	1.3	0.3	0.7	-0.3	0.2	1.1
Parametrial fat weight	2.9	5.7	10.9	-3.3	-2.9	-2.8	-2.3	-3.3	-1.4	0.1	0.8
Pavlov. Cond. lever latency	2.3	3.0	9.6	-2.0	0.6	-0.8	-0.5	-3.1	-2.0	-1.8	-1.3
Pavlov. Cond. magazine entry latency	0.6	0.7	1.9	1.0	-0.0	0.7	0.6	0.9	1.0	0.4	1.4
Pavlov. Cond. change in total contacts	2.9	3.1	10.4	2.4	0.2	1.7	1.0	3.2	1.4	1.2	1.3
Pavlov. Cond. index score	2.2	2.8	5.8	2.1	-0.1	1.2	1.0	2.4	2.2	1.0	2.0
Pavlov. Cond. latency score	2.5	3.2	7.4	2.2	-0.1	1.3	0.9	2.7	2.4	1.2	1.8
Pavlov. Cond. lever contacts	2.2	2.6	6.7	1.8	-0.6	0.7	0.5	2.6	2.2	1.5	1.5
Pavlov. Cond. magazine entry number	1.0	1.3	2.9	-1.3	-0.1	-1.1	-0.9	-1.3	-1.3	-0.4	-1.7
Pavlov. Cond. intertrial magazine entries	2.4	2.9	5.7	-1.9	-1.8	-1.3	-2.4	-0.1	-1.3	1.7	-2.0
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.0	5.9	2.2	-0.1	1.2	1.0	2.4	2.3	1.0	2.1
Pavlov. Cond. response bias	1.4	1.7	4.7	1.5	-0.5	0.8	0.6	2.2	1.4	1.3	1.6
Pavlov. Cond. lever latency	0.9	1.2	2.3	1.5	1.5	1.2	1.1	1.3	0.7	-0.3	0.3
Pavlov. Cond. magazine entry latency	4.3	5.0	8.7	-3.0	-1.7	-2.8	-2.2	-2.4	-1.9	0.4	-2.3
Pavlov. Cond. change in total contacts	1.5	2.0	4.2	-1.8	-1.8	-1.9	-1.3	-2.0	-0.4	-0.1	-0.0
Pavlov. Cond. index score	2.2	2.9	5.7	-2.3	-1.5	-2.1	-1.5	-2.4	-1.3	-0.2	-1.1
Pavlov. Cond. latency score	1.5	1.9	4.4	-1.8	-1.0	-1.7	-1.1	-2.1	-1.0	-0.4	-0.9
Pavlov. Cond. lever contacts	0.8	1.1	2.0	-1.4	-1.4	-1.2	-1.1	-1.3	-0.4	0.1	-0.3
Pavlov. Cond. magazine entry number	2.5	3.1	5.7	2.4	1.7	2.4	1.8	2.2	1.0	-0.1	1.3
Pavlov. Cond. intertrial magazine entries	1.4	1.8	4.2	1.7	0.6	1.8	0.7	2.0	1.4	0.6	0.9
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	5.4	-2.1	-1.4	-2.0	-1.3	-2.3	-1.1	-0.4	-0.7
Pavlov. Cond. response bias	2.0	2.8	5.1	-2.3	-2.0	-2.0	-1.9	-1.7	-1.2	0.6	-1.0
Time in closed arm before self-admin	0.3	0.4	1.4	-0.4	-0.2	-0.3	-0.5	0.1	-1.2	0.6	-0.9
Time in closed arm after self-admin	0.6	0.6	1.7	-0.7	-0.2	-0.8	-0.5	-0.3	-1.1	0.6	-1.3
Time in open arm before self-admin	0.6	0.7	1.5	0.2	0.4	-0.1	0.7	-1.1	1.0	-1.2	1.0
Time in open arm after self-admin	0.9	1.0	4.2	0.2	0.1	0.4	0.6	-1.0	1.1	-1.2	2.0
Bone: periosteal estimation	1.6	3.3	8.1	-1.8	-2.8	-1.8	-2.4	-0.1	-0.3	2.3	-0.8
Bone: periosteal perimeter	0.9	1.4	3.9	-1.1	-2.0	-0.9	-1.7	0.1	0.0	1.7	-0.4
Bone: post-yield work	0.2	0.2	0.8	-0.3	-0.4	-0.5	-0.3	-0.2	0.9	0.3	-0.4
Progressive ratio test 1 active lever presses	0.1	0.2	0.5	-0.2	-0.5	-0.2	-0.1	-0.1	-0.0	0.6	0.7
Progressive ratio test 1 breakpoint	0.2	0.2	1.1	0.0	-0.4	0.0	0.1	-0.0	0.1	0.4	1.0
Progressive ratio test 1 inactive lever presses	1.1	1.2	1.9	-1.3	-1.0	-1.2	-1.2	-0.3	-1.0	1.0	-1.4
Progressive ratio test 2 active lever presses	1.4	1.5	3.5	-0.9	-1.8	-1.5	-1.3	0.5	-0.5	1.9	-0.4
Progressive ratio test 2 breakpoint	1.3	1.4	3.6	-0.8	-1.9	-1.3	-1.3	0.6	-0.3	1.9	-0.1
Progressive ratio test 2 inactive lever presses	4.0	4.6	6.9	-2.4	-2.6	-2.6	-2.6	-0.6	-1.4	2.3	-1.7
Incentive Sensitization - Responses	4.4	4.5	10.0	-1.7	-3.2	-2.1	-2.7	0.8	-0.9	2.9	-0.9
Incentive Sensitization - Breakpoint	4.7	4.8	10.7	-2.0	-3.3	-2.3	-2.8	0.5	-1.0	2.9	-1.0
Sum of active levers in priming session hrs 5-6	1.4	1.4	5.0	0.8	2.2	1.2	1.5	-0.4	0.0	-1.2	0.0
Progressive ratio	0.9	1.0	3.0	0.4	1.7	0.9	1.0	-0.7	0.3	-1.5	-0.6
Food seeking constrained by brief footshock	5.5	6.8	10.1	2.7	3.2	2.5	3.1	-0.2	3.1	-2.6	2.1
Seeking ratio, punishment vs. effort	1.0	1.2	3.6	1.1	0.4	0.6	1.1	-0.1	1.7	-0.6	1.9
Retroperitoneal fat weight	2.5	8.3	17.9	-3.8	-4.2	-3.4	-3.2	-2.7	-1.9	1.1	0.5
Reaction time number correct	0.6	0.9	3.0	0.5	1.7	1.7	0.7	0.2	0.0	-0.4	-0.7
Reaction time mean minus median	1.6	2.2	5.1	-2.0	-1.0	-2.2	-1.0	-2.3	-1.1	-0.4	-0.7
Reaction time mean minus median AUC	2.1	2.7	5.2	-2.3	-1.2	-2.2	-1.4	-2.3	-1.5	0.1	-1.0
Reaction time num false alarms	0.2	0.3	1.6	0.6	0.1	0.3	0.1	1.3	-0.3	0.5	-0.3
Reaction time num false alarms AUC	0.3	0.4	1.1	0.8	0.7	0.6	0.5	1.1	-0.2	0.0	-0.2
Reaction time trials correct on left	0.6	0.9	3.0	0.5	1.7	1.7	0.7	0.2	0.0	-0.4	-0.7
Reaction time trials on left	0.5	0.8	2.6	0.4	1.6	1.6	0.5	0.1	-0.1	-0.3	-0.8
Reaction time mean	2.8	4.0	9.3	-2.5	-1.0	-2.9	-1.1	-3.0	-1.8	-0.9	-1.3
Reaction time mean AUC	2.4	3.2	8.2	-2.2	-0.8	-2.6	-1.0	-2.9	-1.5	-1.0	-1.1
Median of all reaction times	2.4	3.3	7.7	-2.2	-0.8	-2.6	-0.9	-2.8	-1.7	-1.0	-1.3
Reaction time omissions	3.2	4.4	7.6	-2.6	-1.9	-2.8	-2.1	-1.4	-2.6	0.7	-1.8
Reaction time false alarm rate	0.2	0.2	0.7	0.2	-0.5	-0.6	-0.2	0.9	-0.4	0.5	-0.1
Reaction time premature initiation rate	0.1	0.1	0.5	0.4	0.3	0.7	0.1	0.6	0.1	0.2	0.0
Reaction time premature initiations	0.6	0.8	3.0	0.8	1.3	1.7	0.7	0.7	0.1	-0.3	-0.2
Std. dev. reaction times	2.6	3.6	8.4	-2.4	-1.3	-2.9	-1.4	-2.5	-1.8	-0.4	-1.3
Reaction time trials completed	0.5	0.8	2.6	0.4	1.6	1.6	0.5	0.1	-0.1	-0.3	-0.8
Reaction time trials AUC	0.4	0.6	1.8	0.1	1.3	1.3	0.2	0.0	-0.4	-0.1	-1.2
Run reversals in cocaine runway, females	1.3	1.2	2.4	-1.4	-1.6	-1.4	-1.2	-1.3	0.4	0.4	0.3
Run reversals in cocaine runway, males	0.7	0.7	3.2	0.6	-0.5	0.4	0.2	0.6	1.0	-0.0	1.8
Latency to leave start box in cocaine runway	1.2	1.3	2.6	-1.4	-0.7	-1.2	-1.2	-1.1	-1.6	0.1	-1.2
Latency to leave start box in cocaine runway, F	1.7	1.9	3.6	-1.7	-0.7	-1.6	-1.2	-1.1	-1.9	0.3	-1.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.4	-0.1	-0.6	-0.2	-0.6	-0.2	-0.1	0.1	0.4
Std. dev. time between licks in bursts	0.6	0.7	2.7	0.8	-0.3	0.9	-0.2	1.7	0.4	1.0	-0.1
Total sessions with >9 infusions	0.4	0.4	1.6	-0.9	-0.5	-0.9	-0.4	-1.2	-0.0	-0.0	-0.1
Short access day 1 total inactive lever presses	2.4	2.6	6.1	-2.0	-1.0	-2.0	-1.6	-1.2	-1.2	0.8	-2.5
Short access day 10 total inactive lever presses	1.3	1.4	2.7	-1.5	-0.4	-1.2	-1.0	-1.3	-1.5	-0.2	-1.6
Short access day 1 total infusions	0.2	0.2	0.7	-0.4	0.4	-0.2	0.1	-0.8	0.3	-0.2	-0.6
Short access day 10 total infusions	0.3	0.3	1.5	-0.4	0.6	-0.2	0.4	-1.2	-0.2	-0.5	-0.0
Short access total infusions	0.4	0.4	2.2	-0.7	0.2	-0.6	0.0	-1.5	-0.2	-0.4	-0.0
Short access day 1 locomotion	0.7	0.7	2.5	-0.3	0.5	-0.0	0.4	-1.6	0.9	-1.3	0.3
Short access day 10 total locomotion	0.5	0.5	1.9	0.9	0.6	0.5	0.7	0.6	1.4	-0.4	0.1
Short access total locomotion	0.8	0.8	2.5	0.6	0.6	0.4	0.8	-0.6	1.6	-1.0	1.1
One hour access (0.3 mA shock)	0.2	0.3	1.0	-0.5	-0.4	-1.0	-0.4	-0.5	0.1	0.2	-0.6
Compulsive drug intake	0.5	0.5	1.6	-0.6	-0.6	-1.0	-0.8	-0.2	0.2	-0.0	-1.3
One hour access (shock baseline)	0.1	0.1	0.2	-0.2	-0.0	-0.5	0.2	-0.2	-0.4	0.2	0.1
Social response proportion	1.1	1.2	5.1	-0.8	0.1	-0.2	0.2	-2.3	0.1	-1.7	0.9
Social responses	0.9	1.2	2.0	0.9	1.4	1.4	1.2	-0.3	0.9	-1.4	0.8
Social time	0.3	0.4	1.1	-0.3	0.4	0.0	0.3	-1.1	-0.3	-1.1	0.6
Soleus weight	0.7	2.2	4.1	-1.4	-2.0	-1.8	-1.8	0.2	-0.9	1.8	-1.2
Bone: stiffness	0.9	1.4	3.7	-0.5	-1.8	-0.2	-1.6	1.2	0.2	1.9	-0.3
Tibialis anterior weight	0.7	2.3	5.8	-1.6	-2.4	-1.9	-1.8	-0.5	-0.3	1.7	-0.3
Time to tail flick, vehicle, before self-admin	5.2	5.3	8.8	-3.0	-1.3	-2.9	-1.9	-2.6	-2.9	0.0	-2.1
Time to tail flick, vehicle, after self-admin	0.5	0.6	2.1	0.9	0.5	0.4	0.6	1.4	-0.6	0.4	-0.6
Time to tail flick, test, before self-admin	0.2	0.2	0.4	0.3	0.6	-0.2	0.6	-0.2	0.0	-0.4	-0.4
Time to tail flick, test, after self-admin	3.4	3.5	8.9	-2.1	-0.6	-2.2	-1.5	-1.1	-2.5	0.6	-3.0
Delta time to tail flick, vehicle, before/after SA	2.5	2.5	10.7	1.9	0.3	1.7	0.7	3.3	0.6	1.3	0.1
Delta time to tail flick, test, before/after SA	2.8	2.5	4.0	-1.8	-1.3	-1.9	-1.8	-0.6	-1.6	0.9	-2.0
Tibia length	0.4	1.1	2.9	-0.6	-1.7	-0.3	-0.8	-0.4	1.0	0.7	1.7
Ambulatory time before self-admin	0.6	0.7	1.0	0.7	0.8	0.7	1.0	-0.1	0.9	-0.9	1.0
Ambulatory time after self-admin	2.3	2.6	5.8	1.8	1.2	2.4	1.5	1.2	1.1	-0.5	2.3
Bone: tissue strength	0.8	0.8	4.9	0.3	-0.5	0.3	-0.0	-0.2	2.2	-0.2	1.1
Total heroin consumption	1.4	1.6	3.7	-1.5	0.4	-1.3	-0.5	-1.9	-1.3	-1.0	-1.6
Bone: trabecular number	1.0	1.6	3.7	-0.5	-1.8	-1.0	-1.4	1.1	-0.8	1.9	-0.8
Bone: trabecular spacing	0.7	0.9	1.7	0.5	1.1	0.9	1.2	-0.5	-0.2	-1.1	1.3
Bone: trabecular thickness	0.8	0.9	1.6	-0.7	-1.1	-1.3	-0.9	0.3	-1.1	1.0	-0.9
Bone: trabecular tissue density	0.3	0.4	1.0	0.3	-0.7	-0.1	-0.0	0.5	0.7	0.9	1.0
Water consumed over 24 hours	0.6	0.7	1.8	-1.0	-0.1	-1.1	-0.5	-1.3	-0.0	-0.2	-1.1
Number of responses in last shaping day	0.4	0.4	1.2	0.0	0.9	-0.1	0.5	-0.4	0.3	-0.6	-1.1