Hub : Genes

Slc22a4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative TSS XM_039086773.1 0.03 0.03 1.0e-03 0.03 0.03 0.01 0.03 9.7e-04 9.8e-04 1.3e-02 1.2e-03
2 Liver gene expression Slc22a4 0.04 0.04 2.4e-04 0.03 0.02 0.02 0.03 4.4e-04 1.2e-03 1.1e-03 8.4e-04
3 Adipose alternative TSS XM_039086773.1 0.05 0.05 1.8e-05 0.03 0.04 0.04 0.04 1.7e-04 8.9e-05 6.3e-05 4.9e-05
4 BLA alternative TSS XM_039086773.1 0.15 0.13 2.5e-06 0.07 0.11 0.11 0.11 1.2e-04 2.0e-06 1.9e-06 2.5e-06
5 Liver alternative TSS XM_039086773.1 0.16 0.14 3.8e-07 0.04 0.04 0.04 0.04 7.4e-05 3.2e-05 6.9e-05 5.9e-05
6 NAcc alternative TSS XM_039086773.1 0.03 0.03 1.0e-03 0.02 0.02 0 0.01 3.8e-03 1.8e-03 1.3e-01 6.3e-03
7 BLA isoform ratio XM_039086772.1 0.07 0.07 1.0e-03 0.02 0.04 0.04 0.03 2.9e-02 2.2e-03 5.4e-03 7.4e-03
8 NAcc alternative TSS XM_039086772.1 0.03 0.03 1.6e-04 0.03 0.03 0.03 0.03 3.2e-04 1.7e-04 5.9e-04 4.6e-04
9 Brain mRNA stability Slc22a4 0.11 0.06 1.9e-14 0.12 0.14 0.13 0.12 1.1e-11 7.2e-13 5.6e-12 1.1e-11
10 Brain alternative TSS XM_039086772.1 0.05 0.04 2.0e-04 0.03 0.03 0.02 0.03 1.0e-03 4.4e-04 2.4e-03 1.6e-03
11 Liver alternative TSS NM_022270.2 0.04 0.03 1.1e-04 0.02 0.03 0.02 0.02 3.0e-03 5.9e-04 1.6e-03 1.6e-03
12 Liver alternative TSS XM_039086772.1 0.06 0.06 3.6e-05 0.03 0.03 0.03 0.03 1.3e-04 5.6e-04 3.8e-04 3.4e-04
13 Adipose gene expression Slc22a4 0.05 0.09 5.1e-03 0.01 0 0.01 0.01 2.7e-02 9.8e-02 3.2e-02 4.5e-02
14 Liver alternative TSS NM_022270.2 0.03 0.03 1.3e-04 0.02 0.03 0.02 0.02 5.2e-03 7.2e-04 2.0e-03 2.0e-03
15 Liver isoform ratio XM_039086772.1 0.02 0.02 5.0e-03 0 0.01 0 0 7.5e-02 1.9e-02 1.4e-01 8.5e-02
16 Adipose alternative TSS XM_039086772.1 0.02 0.02 8.3e-03 0.01 0.01 0 0.01 2.9e-02 2.0e-02 3.4e-01 5.2e-02
17 PL alternative TSS XM_039086773.1 0.06 0.05 2.4e-07 0.06 0.05 0.05 0.05 8.7e-07 1.9e-06 1.2e-06 1.3e-06
18 PL alternative TSS NM_022270.2 0.03 0.03 2.9e-03 0.01 0.01 0.02 0.01 1.5e-02 1.1e-02 5.5e-03 1.3e-02
19 PL alternative TSS NM_022270.2 0.03 0.03 2.3e-03 0.02 0.01 0.02 0.01 2.2e-03 1.1e-02 4.7e-03 7.2e-03
20 PL alternative TSS XM_039086772.1 0.07 0.06 1.3e-08 0.07 0.07 0.07 0.07 2.8e-08 4.4e-08 3.4e-08 3.1e-08
21 PL isoform ratio XM_039086772.1 0.05 0.04 4.3e-06 0.04 0.04 0.04 0.04 6.6e-05 1.3e-05 1.2e-05 2.3e-05
22 pVTA alternative TSS XM_039086772.1 0.13 0.22 8.5e-04 0.08 0.14 0.16 0.08 3.2e-04 2.0e-06 2.7e-07 1.9e-04
23 Brain gene expression Slc22a4 0.12 0.06 7.8e-14 0.14 0.14 0.15 0.14 6.2e-13 3.6e-13 1.9e-13 4.7e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bone: apparent density0.10.23.4-0.5-0.30.1-0.00.10.20.20.2-0.30.3-0.2-0.2-0.2-0.20.20.2-0.3-0.1-0.1-0.3-0.1-0.81.8
Area under the delay curve0.00.00.1-0.10.3-0.20.1-0.2-0.2-0.2-0.20.2-0.20.20.10.10.2-0.2-0.20.3-0.2-0.20.30.30.20.1
BMI with tail0.10.33.00.4-0.00.2-0.2-0.2-0.3-0.3-0.30.3-0.30.30.30.30.3-0.3-0.20.10.60.6-0.00.90.51.7
BMI without tail0.10.10.80.3-0.30.3-0.4-0.0-0.1-0.0-0.10.1-0.10.00.20.20.0-0.1-0.0-0.10.90.9-0.0-0.40.3-0.4
Body weight0.72.95.61.81.8-1.51.6-1.7-1.7-1.7-1.71.7-1.71.71.71.71.7-1.7-1.71.9-1.4-1.41.72.42.01.0
Weight adjusted by age0.10.10.30.40.1-0.10.2-0.4-0.4-0.4-0.40.4-0.40.40.60.60.4-0.4-0.40.2-0.0-0.00.30.50.40.2
Bone surface0.00.00.30.10.2-0.30.3-0.2-0.1-0.1-0.10.1-0.10.10.10.10.1-0.1-0.20.2-0.4-0.40.10.1-0.20.5
Bone volume0.20.31.4-0.7-0.50.4-0.30.50.60.50.6-0.60.6-0.5-0.5-0.5-0.50.60.5-0.40.10.1-0.5-0.5-1.01.2
Breakpoint value in progressive ratio session1.61.72.3-1.1-1.31.2-1.01.41.41.41.4-1.41.4-1.4-1.4-1.4-1.41.41.4-1.10.90.9-1.3-1.5-1.31.1
Number of licking bursts0.10.10.10.20.4-0.30.3-0.3-0.3-0.3-0.30.3-0.30.30.20.20.3-0.3-0.30.3-0.3-0.30.20.40.1-0.2
Context. condit. distance diff. score0.10.10.70.20.2-0.40.4-0.3-0.3-0.3-0.30.2-0.30.30.40.40.3-0.3-0.30.3-0.4-0.40.30.5-0.00.8
Locomotion velocity, session 10.10.10.2-0.2-0.20.3-0.30.20.20.20.2-0.20.3-0.2-0.2-0.2-0.20.20.3-0.40.30.3-0.4-0.0-0.5-0.1
Locomotion distance, session 10.20.30.50.50.6-0.70.6-0.5-0.5-0.5-0.50.5-0.50.50.50.50.5-0.5-0.50.4-0.7-0.70.40.30.00.1
Locomotion velocity, session 20.80.91.50.90.9-0.91.0-1.0-1.0-1.0-1.01.0-1.01.00.90.91.0-1.0-1.00.9-0.9-0.90.91.10.71.2
Locomotion distance, session 20.30.40.50.60.7-0.60.6-0.6-0.7-0.7-0.60.7-0.70.70.50.50.7-0.7-0.60.5-0.6-0.60.50.70.40.4
Locomotion velocity, session 33.03.44.32.02.0-2.02.1-1.9-1.8-1.9-1.81.8-1.81.82.12.11.8-1.8-1.81.8-2.1-2.11.91.81.1-0.4
Locomotion distance, session 32.62.83.91.71.8-2.01.9-1.8-1.7-1.7-1.71.6-1.71.71.81.81.7-1.7-1.71.7-2.0-2.01.81.40.90.1
Stereotopy head waving bouts, day 30.20.20.4-0.3-0.40.6-0.50.60.50.50.5-0.50.5-0.5-0.6-0.6-0.50.50.5-0.50.50.5-0.50.1-0.2-0.3
Stereotopy head waving duration, day 31.82.12.6-1.4-1.31.6-1.61.61.51.51.5-1.51.5-1.5-1.6-1.6-1.51.51.5-1.51.51.5-1.6-0.9-1.1-0.4
Locomotion velocity, session 70.00.00.10.0-0.0-0.20.1-0.1-0.0-0.0-0.00.0-0.00.00.10.10.0-0.0-0.00.1-0.2-0.20.10.0-0.20.2
Locomotion distance, session 70.10.11.2-0.2-0.10.2-0.30.30.30.30.3-0.30.3-0.3-0.4-0.4-0.30.30.3-0.30.20.2-0.3-0.3-0.3-1.1
Stereotopy head waving bouts, day 70.40.50.6-0.7-0.60.7-0.70.70.80.70.8-0.80.8-0.8-0.7-0.7-0.80.80.8-0.60.60.6-0.6-0.2-0.60.3
Stereotopy head waving duration, day 71.01.31.4-1.1-1.11.2-1.21.21.21.21.2-1.21.2-1.2-1.2-1.2-1.21.21.2-1.01.21.2-1.1-0.9-0.7-0.4
Locomotion velocity, session 82.32.73.21.61.5-1.81.8-1.8-1.7-1.7-1.71.7-1.71.71.71.71.7-1.7-1.71.7-1.7-1.71.71.61.01.0
Locomotion distance, session 80.91.31.71.21.2-1.21.3-1.1-1.1-1.1-1.11.2-1.11.21.21.21.2-1.2-1.21.0-1.3-1.31.11.30.60.3
Degree of sensitization distance3.53.64.6-1.7-1.92.1-2.12.01.91.91.9-1.81.9-1.9-2.0-2.0-1.91.91.9-1.92.12.1-2.0-1.7-1.0-1.4
Degree of sensitization stereotypy0.00.00.1-0.2-0.20.2-0.20.20.20.20.2-0.20.2-0.2-0.2-0.2-0.20.20.2-0.20.20.2-0.10.1-0.10.1
Conditioned locomotion0.40.41.40.70.8-0.50.6-0.6-0.6-0.6-0.60.7-0.60.60.60.60.6-0.6-0.60.4-0.6-0.60.40.7-0.0-1.2
Cocaine response after cond. corrected0.10.10.6-0.2-0.20.00.00.10.20.20.2-0.20.2-0.2-0.1-0.1-0.20.20.2-0.2-0.1-0.1-0.2-0.4-0.80.4
Cocaine response after cond. not corrected0.50.61.7-0.9-0.70.6-0.60.70.80.80.8-0.80.8-0.8-0.8-0.8-0.80.80.7-0.90.40.4-0.8-1.3-1.20.1
Cocaine response before conditioning1.82.13.3-1.5-1.41.4-1.61.51.51.51.5-1.51.5-1.5-1.6-1.6-1.51.51.5-1.51.51.5-1.4-1.8-1.0-0.5
Saline control response1.41.93.4-1.2-1.01.4-1.41.51.41.41.4-1.31.4-1.4-1.4-1.4-1.41.41.4-1.41.41.4-1.4-1.0-1.2-1.9
Bone: connectivity density0.10.11.6-0.3-0.20.1-0.10.10.20.20.2-0.20.2-0.2-0.2-0.2-0.20.20.1-0.1-0.0-0.0-0.2-0.3-0.31.3
Bone: cortical apparent density0.81.11.5-1.1-1.21.1-1.11.11.11.11.1-1.21.1-1.1-1.0-1.0-1.11.11.1-1.01.01.0-1.0-0.8-0.90.0
Bone: cortical area0.50.71.10.80.9-0.91.0-0.9-0.9-0.9-0.90.9-0.90.90.80.80.9-0.9-0.90.7-1.0-1.00.70.50.40.5
Bone: cortical porosity0.00.00.2-0.00.0-0.10.1-0.1-0.0-0.0-0.00.0-0.00.00.10.10.0-0.0-0.00.1-0.0-0.00.20.20.00.5
Bone: cortical porosity0.50.50.7-0.8-0.80.7-0.70.70.70.70.7-0.80.7-0.7-0.6-0.6-0.70.70.7-0.70.70.7-0.6-0.4-0.70.8
Bone: cortical thickness0.30.50.90.60.8-0.90.8-0.8-0.8-0.8-0.70.8-0.80.80.70.70.8-0.8-0.80.6-1.0-1.00.70.40.20.2
Bone: cortical thickness0.10.10.4-0.2-0.00.2-0.20.20.20.20.2-0.20.2-0.2-0.3-0.3-0.20.20.2-0.50.10.1-0.30.0-0.6-0.2
Bone: cortical tissue density0.91.21.6-1.2-1.31.2-1.11.11.21.21.2-1.21.2-1.2-1.0-1.0-1.21.21.2-1.11.01.0-1.0-0.8-1.00.0
Condit. Reinf. active minus inactive responses0.30.32.30.40.5-0.50.5-0.5-0.5-0.5-0.50.5-0.50.50.50.50.5-0.5-0.50.3-0.6-0.60.40.4-0.01.5
Condit. Reinf. active-inactive response ratio0.91.01.21.01.0-1.11.1-1.1-1.0-1.1-1.01.1-1.01.11.01.01.0-1.0-1.10.9-1.1-1.11.01.00.51.1
Condit. Reinf. active responses0.10.10.7-0.3-0.30.3-0.30.30.20.20.2-0.20.2-0.2-0.3-0.3-0.20.20.2-0.50.30.3-0.5-0.3-0.60.8
Condit. Reinf. inactive responses2.32.73.4-1.6-1.71.8-1.71.71.71.71.7-1.61.7-1.7-1.6-1.6-1.71.71.7-1.81.81.8-1.8-1.5-1.6-0.3
Incentive salience index mean1.01.21.61.11.1-1.11.1-1.2-1.2-1.2-1.21.2-1.21.21.11.11.2-1.2-1.20.9-1.1-1.11.01.10.70.9
Condit. Reinf. lever presses1.82.43.51.71.5-1.31.5-1.6-1.7-1.7-1.71.8-1.71.71.51.51.7-1.7-1.71.3-1.3-1.31.41.91.3-0.2
Condit. Reinf. active minus inactive responses0.50.61.2-0.8-0.80.8-0.80.80.80.80.8-0.80.8-0.8-0.7-0.7-0.80.80.8-0.90.70.7-0.9-1.1-1.00.1
Condit. Reinf. active-inactive response ratio0.10.10.10.20.2-0.20.2-0.3-0.3-0.3-0.30.3-0.30.30.30.30.3-0.3-0.30.1-0.2-0.20.2-0.20.2-0.3
Condit. Reinf. active responses1.72.43.7-1.6-1.61.5-1.51.61.61.61.6-1.61.6-1.6-1.5-1.5-1.61.61.6-1.71.41.4-1.7-1.4-1.90.4
Condit. Reinf. inactive responses4.05.07.1-2.3-2.12.2-2.22.32.42.32.4-2.42.4-2.4-2.4-2.4-2.42.42.4-2.42.02.0-2.3-1.5-2.70.8
Condit. Reinf. lever presses0.20.30.9-0.5-0.50.5-0.50.50.50.50.5-0.50.5-0.5-0.5-0.5-0.50.50.5-0.70.30.3-0.7-0.7-1.0-0.2
Condit. Reinf. lever reinforcers received1.62.33.5-1.5-1.61.5-1.51.51.61.51.6-1.61.6-1.6-1.5-1.5-1.61.61.6-1.61.41.4-1.6-1.4-1.90.6
Conditioned reinforcement - actives0.10.10.5-0.70.0-0.2-0.10.30.30.30.3-0.30.3-0.3-0.4-0.4-0.30.30.3-0.1-0.3-0.3-0.1-0.2-0.5-0.1
Conditioned reinforcement - inactives0.60.61.4-1.2-0.50.5-0.60.90.90.90.9-0.90.9-0.9-1.0-1.0-0.90.90.9-0.70.40.4-0.7-0.3-0.80.4
Conditioned locomotion1.82.12.9-1.5-1.51.5-1.61.51.51.51.5-1.51.5-1.5-1.5-1.5-1.51.51.5-1.31.71.7-1.4-1.3-0.60.2
Patch foraging indifference point 0 sec3.55.68.9-2.3-2.01.9-2.12.42.52.52.5-2.52.5-2.5-2.4-2.4-2.52.52.5-2.51.71.7-2.5-2.8-3.0-1.1
Patch foraging indifference point AUC0.00.00.20.20.1-0.20.2-0.1-0.1-0.1-0.10.1-0.10.10.10.10.1-0.1-0.10.0-0.1-0.10.0-0.4-0.5-0.4
Delay disc. indifference point, 0s delay0.10.11.8-0.00.00.0-0.00.20.20.20.2-0.20.2-0.2-0.1-0.1-0.20.20.2-0.5-0.0-0.0-0.40.1-1.30.4
Delay disc. indifference point, 16s delay0.10.10.8-0.2-0.0-0.10.0-0.1-0.1-0.1-0.10.1-0.10.1-0.1-0.10.1-0.1-0.10.4-0.2-0.20.4-0.10.9-0.3
Delay disc. indifference point, 2s delay1.11.32.41.11.2-1.01.1-1.2-1.2-1.2-1.21.2-1.21.21.21.21.2-1.2-1.21.0-1.0-1.01.11.60.70.1
Delay disc. indifference point, 24s delay0.10.10.30.00.3-0.30.3-0.3-0.3-0.3-0.30.4-0.30.40.00.00.4-0.3-0.40.3-0.5-0.50.30.10.40.5
Delay disc. indifference point, 4s delay1.21.22.0-1.4-1.11.1-1.21.11.11.11.1-1.11.1-1.1-1.3-1.3-1.11.11.1-0.91.11.1-1.0-1.2-0.20.9
Delay disc. indifference point, 8s delay0.30.30.80.40.9-0.70.5-0.6-0.6-0.6-0.50.6-0.50.50.50.50.5-0.5-0.50.5-0.6-0.60.60.60.1-0.1
Indifference point function ln k0.20.30.80.60.6-0.70.5-0.6-0.5-0.6-0.50.5-0.50.50.60.60.5-0.5-0.50.5-0.5-0.50.50.30.5-0.9
Indifference point function log k0.20.30.80.60.6-0.70.5-0.6-0.5-0.6-0.50.5-0.50.50.60.60.5-0.5-0.50.5-0.5-0.50.50.30.5-0.9
Patch foraging total patch changes 0 sec3.75.99.2-2.4-2.22.0-2.22.52.62.62.6-2.62.6-2.6-2.5-2.5-2.62.62.6-2.71.91.9-2.6-2.8-3.0-1.0
Patch foraging total patch changes 12 sec4.86.28.2-2.6-2.42.3-2.42.62.62.62.6-2.62.6-2.6-2.7-2.7-2.62.62.6-2.52.22.2-2.5-2.9-2.5-0.7
Patch foraging total patch changes 18 sec1.92.57.1-1.3-1.51.4-1.41.51.51.51.5-1.51.5-1.5-1.4-1.4-1.51.51.5-1.91.31.3-1.8-2.0-2.7-1.2
Patch foraging total patch changes 24 sec3.03.74.5-2.1-1.81.7-1.72.02.12.12.1-2.12.1-2.1-2.1-2.1-2.12.12.0-2.01.51.5-1.9-1.9-2.11.0
Patch foraging total patch changes 6 sec3.85.78.6-2.4-2.42.0-2.22.42.52.52.5-2.52.5-2.5-2.4-2.4-2.52.52.5-2.42.02.0-2.5-2.9-2.6-1.3
Patch foraging time to switch 0 sec0.40.71.2-1.0-1.01.1-1.00.90.80.80.8-0.80.8-0.8-0.9-0.9-0.80.80.8-0.71.01.0-0.6-0.40.30.5
Patch foraging water rate 0 sec0.60.91.71.01.1-1.31.2-1.0-0.9-0.9-0.90.9-0.90.91.01.00.9-0.9-0.91.0-1.3-1.30.90.30.2-0.7
Patch foraging water rate 12 sec0.40.51.10.91.0-1.00.8-0.8-0.7-0.8-0.70.7-0.70.70.70.70.7-0.7-0.70.8-0.7-0.70.70.40.20.2
Patch foraging water rate 18 sec1.11.52.0-1.3-1.21.3-1.31.31.31.31.3-1.31.3-1.3-1.3-1.3-1.31.31.3-1.31.31.3-1.4-0.8-1.0-0.5
Patch foraging water rate 24 sec0.30.40.6-0.7-0.50.6-0.70.70.70.70.7-0.70.7-0.7-0.7-0.7-0.70.70.7-0.60.60.6-0.8-0.5-0.6-0.1
Patch foraging water rate 6 sec1.42.13.31.41.8-1.81.6-1.4-1.3-1.4-1.31.4-1.41.41.31.31.4-1.4-1.41.6-1.7-1.71.61.21.50.4
Seeking ratio, delayed vs. immediate footshock0.30.41.7-0.6-0.30.5-0.50.50.50.50.6-0.50.6-0.6-0.6-0.6-0.60.60.6-0.80.40.4-0.6-0.3-1.3-0.5
Distance traveled before self-admin0.80.91.40.90.9-0.81.0-0.9-0.9-0.9-0.90.9-0.90.91.01.00.9-0.9-0.90.8-1.2-1.20.80.90.6-1.0
Distance traveled after self-admin0.10.10.7-0.3-0.60.7-0.10.40.40.40.4-0.40.4-0.4-0.1-0.1-0.40.40.4-0.3-0.1-0.1-0.30.0-0.2-0.9
Extensor digitorum longus weight0.21.01.6-1.1-0.81.0-1.11.11.01.01.0-1.01.0-1.0-1.2-1.2-1.01.01.0-0.91.01.0-1.0-0.2-0.61.3
Bone: elastic displacement0.20.21.60.10.4-0.50.5-0.4-0.2-0.2-0.20.2-0.20.30.30.30.3-0.2-0.30.4-0.6-0.60.60.60.01.3
Bone: elastic work1.01.22.20.81.2-1.31.3-1.1-1.0-1.0-1.01.0-1.01.11.01.01.0-1.0-1.11.1-1.5-1.51.21.20.51.0
Bone: endosteal estimation0.71.51.81.31.3-1.31.3-1.2-1.2-1.2-1.21.2-1.21.21.21.21.2-1.2-1.21.3-1.3-1.31.30.81.1-1.2
Bone: endosteal perimeter0.81.62.31.31.3-1.11.3-1.3-1.3-1.3-1.31.4-1.31.31.21.21.3-1.3-1.31.2-1.2-1.21.11.51.00.6
Epididymis fat weight2.45.67.52.12.7-2.72.6-2.4-2.3-2.3-2.22.3-2.32.32.22.22.3-2.3-2.32.4-2.7-2.72.32.70.92.7
Delta time in closed arm before/after self-admin0.20.20.3-0.5-0.50.2-0.20.50.50.50.5-0.50.5-0.5-0.5-0.5-0.50.50.5-0.4-0.1-0.1-0.4-0.5-0.60.3
Delta time in open arm before/after self-admin1.00.91.51.00.9-0.80.9-1.1-1.1-1.1-1.11.1-1.11.11.21.21.1-1.1-1.10.6-0.8-0.80.81.20.3-0.5
Diff in mean of infusions in LGA sessions0.10.10.40.40.1-0.30.5-0.3-0.3-0.3-0.30.3-0.30.30.30.30.3-0.3-0.30.3-0.7-0.70.30.1-0.1-0.4
Delay discount exponential model param0.00.00.10.2-0.20.10.00.10.10.10.1-0.10.1-0.10.10.1-0.10.10.2-0.20.10.1-0.2-0.2-0.4-0.2
Extinction: sum of active levers before priming0.10.10.60.20.3-0.40.3-0.2-0.1-0.1-0.10.1-0.10.10.10.10.1-0.1-0.10.2-0.2-0.20.20.1-0.30.8
Active lever presses in extinction session 62.02.02.6-1.3-1.61.5-1.41.51.51.51.4-1.51.5-1.5-1.4-1.4-1.51.51.5-1.41.41.4-1.4-1.4-1.1-0.8
Bone: final force1.32.13.21.31.6-1.71.6-1.5-1.4-1.5-1.41.4-1.41.41.41.41.4-1.4-1.51.5-1.8-1.81.41.00.8-0.5
Bone: final moment1.11.82.91.31.5-1.61.6-1.4-1.4-1.4-1.41.4-1.41.41.31.31.4-1.3-1.41.4-1.7-1.71.30.90.7-0.5
Food consumed during 24 hour testing period5.97.18.32.82.7-2.72.9-2.8-2.8-2.8-2.82.8-2.82.82.82.82.8-2.8-2.82.7-2.9-2.92.72.42.0-0.6
Glucose0.20.31.80.40.8-0.60.4-0.5-0.5-0.5-0.50.5-0.50.50.30.30.5-0.5-0.50.8-0.3-0.30.7-0.11.4-0.6
Heart weight0.60.91.70.60.9-1.21.1-0.9-0.7-0.7-0.70.7-0.70.80.70.70.8-0.7-0.81.3-1.3-1.31.30.31.21.0
Delay discount hyperbolic model param0.00.00.20.1-0.20.10.00.10.10.10.1-0.10.1-0.10.00.0-0.10.10.1-0.20.00.0-0.2-0.2-0.4-0.2
Intermittent access intake day 1-15 change0.70.61.1-1.0-0.80.8-0.80.80.80.80.8-0.80.8-0.8-0.8-0.8-0.80.80.8-0.90.60.6-1.0-0.5-1.0-1.0
Intermittent access intake escalation0.50.51.1-1.1-0.50.5-0.60.70.70.70.7-0.70.7-0.7-0.7-0.7-0.70.70.7-0.70.30.3-0.8-0.5-0.8-0.9
Intermittent access intake escalation 20.80.81.1-1.1-0.80.8-0.90.90.90.90.9-0.80.9-0.9-0.9-0.9-0.90.90.9-1.00.80.8-1.0-0.6-1.1-0.3
Intermitt. access day 1 inactive lever presses0.10.10.7-0.30.0-0.10.10.20.20.20.2-0.20.2-0.2-0.3-0.3-0.20.20.2-0.1-0.3-0.3-0.30.1-0.80.0
Intermitt. access day 15 inactive lever presses0.00.00.2-0.1-0.20.00.1-0.1-0.1-0.1-0.10.1-0.10.10.10.10.1-0.1-0.1-0.0-0.2-0.20.00.3-0.1-0.4
Intermitt. access escalation Index0.40.40.70.80.6-0.70.8-0.6-0.6-0.6-0.60.6-0.60.60.60.60.6-0.6-0.60.6-0.7-0.70.50.60.30.7
Intermittent access day 1 total infusions0.10.10.30.00.3-0.40.3-0.2-0.1-0.1-0.10.1-0.20.20.10.10.2-0.1-0.20.3-0.4-0.40.60.40.30.2
Intermittent access day 15 total infusions0.60.72.1-1.5-0.50.4-0.70.90.90.90.9-0.90.9-0.9-1.0-1.0-0.90.90.9-0.60.30.3-0.6-0.7-0.6-0.4
Intermittent access terminal intake (last 3 days)1.11.22.8-1.7-1.00.7-1.01.21.21.21.2-1.21.2-1.2-1.3-1.3-1.21.21.2-0.90.70.7-0.8-1.1-0.5-0.4
Intermittent access total infusions0.30.41.3-1.1-0.50.4-0.60.70.70.70.7-0.70.6-0.6-0.8-0.8-0.60.60.6-0.40.30.3-0.2-0.50.2-0.6
Intermittent access day 1 locomotion0.40.40.8-0.8-0.70.4-0.50.70.80.70.7-0.80.7-0.7-0.8-0.8-0.70.70.7-0.20.40.4-0.3-0.90.10.5
Intermittent access day 15 total locomotion5.35.77.7-2.8-2.52.3-2.52.62.62.62.6-2.62.5-2.5-2.7-2.7-2.52.52.5-1.82.42.4-2.0-2.5-0.80.2
Intermittent access total locomotion3.94.45.8-2.4-2.22.0-2.22.32.32.32.3-2.32.2-2.2-2.4-2.4-2.22.22.2-1.72.12.1-1.8-2.1-0.70.3
Intermittent access standard deviation0.10.10.40.20.6-0.30.4-0.3-0.3-0.3-0.30.3-0.30.30.30.30.3-0.3-0.30.2-0.4-0.40.20.60.10.1
Left kidney weight7.220.428.14.55.3-5.14.9-4.5-4.5-4.6-4.54.6-4.64.64.34.34.6-4.5-4.64.7-5.0-5.04.74.13.7-0.5
Right kidney weight5.415.120.53.84.4-4.54.1-4.0-3.9-4.0-3.93.9-3.94.03.83.84.0-3.9-4.04.3-4.2-4.24.12.63.6-0.8
Cocaine induced anxiety0.40.51.0-0.8-1.01.0-0.80.70.60.70.6-0.60.6-0.6-0.7-0.7-0.60.60.6-0.90.80.8-0.6-0.60.0-0.2
Post-drug Anxiety2.93.34.6-2.0-2.22.1-2.01.91.81.81.8-1.81.8-1.8-1.9-1.9-1.81.81.8-1.91.91.9-1.8-1.7-0.9-0.4
Baseline Anxiety0.60.61.0-0.9-0.50.6-0.70.80.90.80.9-0.90.9-0.9-0.9-0.9-0.90.90.9-0.70.60.6-0.8-0.8-1.00.0
Tail length0.82.45.11.71.7-1.81.6-1.5-1.5-1.5-1.51.5-1.51.51.61.61.5-1.5-1.51.5-1.4-1.41.60.21.2-2.3
Length with tail1.66.07.42.52.7-2.52.5-2.4-2.4-2.5-2.42.4-2.52.42.52.52.4-2.4-2.42.6-2.5-2.52.52.32.6-1.1
Length without tail2.65.711.32.12.6-2.32.4-2.3-2.3-2.3-2.32.3-2.32.32.22.22.3-2.3-2.32.6-2.6-2.62.43.42.61.4
Times rat made contact with spout0.91.11.41.00.9-1.01.1-1.0-1.0-1.0-1.01.0-1.11.11.01.01.1-1.1-1.11.2-1.1-1.11.11.01.20.4
Lifetime Intake0.10.10.4-0.7-0.20.0-0.20.30.30.30.3-0.30.3-0.3-0.4-0.4-0.30.30.20.0-0.0-0.00.2-0.10.6-0.5
Liver weight, left0.10.11.0-0.10.10.2-0.10.10.10.10.1-0.10.1-0.1-0.1-0.1-0.10.10.1-0.30.10.1-0.21.0-0.80.8
Liver weight, right0.10.10.6-0.30.20.1-0.00.20.20.10.2-0.10.2-0.2-0.4-0.4-0.20.20.2-0.3-0.3-0.3-0.30.8-0.70.5
Locomotor activity1.62.53.8-1.7-1.92.0-1.81.61.61.61.6-1.61.6-1.6-1.4-1.4-1.61.61.6-1.61.81.8-1.6-0.9-1.2-1.0
Locomotor testing distance3.45.68.1-2.3-2.92.8-2.52.32.32.42.3-2.32.4-2.4-2.1-2.1-2.42.42.4-2.72.42.4-2.6-1.5-2.7-1.2
Locomotor testing rearing2.23.45.9-1.7-2.32.2-1.91.81.81.81.8-1.81.8-1.8-1.6-1.6-1.81.81.8-2.22.02.0-2.0-1.3-2.4-0.1
Locomotion in novel chamber0.10.11.6-0.40.1-0.1-0.10.10.00.00.0-0.00.0-0.0-0.1-0.1-0.00.0-0.00.2-0.1-0.10.3-0.40.5-1.3
Locomotion in novel chamber post-restriction0.00.00.3-0.10.4-0.0-0.1-0.0-0.0-0.1-0.00.0-0.00.0-0.0-0.00.0-0.0-0.00.10.10.10.20.20.20.6
Fecal boli incidents, locomotor time 10.20.21.90.1-0.50.8-0.50.10.10.10.1-0.10.1-0.10.10.1-0.10.10.1-0.10.80.8-0.1-0.21.40.0
Change in fecal boli incidents, locomotor task1.71.63.81.01.0-1.41.3-1.2-1.3-1.2-1.31.3-1.31.31.11.11.3-1.3-1.31.1-1.5-1.51.31.30.5-1.9
Time >=10cm from walls, locomotor time 12.32.33.4-1.8-1.21.2-1.31.61.71.61.6-1.61.7-1.6-1.8-1.8-1.61.71.6-1.40.90.9-1.6-1.6-1.6-0.3
Bouts of movement, locomotor time 10.20.30.6-0.6-0.40.6-0.60.50.50.50.5-0.50.5-0.5-0.5-0.5-0.50.50.5-0.30.50.5-0.4-0.60.2-0.8
Total resting periods, locomotor time 10.20.21.4-0.6-0.30.3-0.40.40.40.40.3-0.40.4-0.4-0.4-0.4-0.40.40.3-0.20.20.2-0.2-0.50.3-1.2
Rest time, locomotor task time 10.30.31.7-0.6-0.40.5-0.60.60.60.60.5-0.60.6-0.6-0.5-0.5-0.60.60.6-0.30.50.5-0.4-0.5-0.2-1.3
Distance moved, locomotor task time 10.20.20.70.30.4-0.50.6-0.4-0.4-0.4-0.40.4-0.40.40.20.20.4-0.4-0.40.6-0.8-0.80.50.20.2-0.1
Vertical activity count, locomotor time 10.20.20.5-0.5-0.40.4-0.40.40.40.40.4-0.40.4-0.4-0.5-0.5-0.40.40.4-0.20.30.3-0.6-0.7-0.40.4
Time >=10cm from walls, locomotor time 20.00.00.20.10.2-0.20.3-0.1-0.1-0.1-0.10.1-0.10.10.20.20.1-0.1-0.10.1-0.2-0.20.00.2-0.40.3
Bouts of movement, locomotor time 20.20.20.8-0.5-0.60.5-0.60.50.40.40.4-0.40.4-0.4-0.4-0.4-0.40.40.4-0.60.60.6-0.5-0.5-0.2-0.9
Total resting periods, locomotor time 20.20.20.8-0.5-0.60.4-0.60.50.40.40.4-0.40.4-0.4-0.4-0.4-0.40.40.4-0.60.50.5-0.5-0.5-0.3-0.9
Rest time, locomotor task time 21.51.72.7-1.7-1.21.1-1.41.41.41.41.4-1.41.4-1.4-1.6-1.6-1.41.41.3-1.11.21.2-1.0-1.6-0.6-0.1
Distance moved, locomotor task time 20.10.21.1-0.10.5-0.30.30.00.10.00.1-0.10.1-0.1-0.2-0.2-0.10.10.10.0-0.5-0.5-0.10.3-1.11.1
Vertical activity count, locomotor time 20.10.10.4-0.2-0.30.5-0.40.30.40.40.4-0.40.4-0.4-0.2-0.2-0.40.40.4-0.20.60.6-0.5-0.1-0.30.2
Light reinforcement 11.22.22.6-1.5-1.41.5-1.61.51.51.51.5-1.51.5-1.5-1.5-1.5-1.51.51.5-1.61.61.6-1.5-1.3-1.5-0.8
Light reinforcement 20.10.21.10.00.4-0.40.3-0.3-0.3-0.3-0.30.3-0.30.30.20.20.3-0.3-0.30.4-0.5-0.50.40.10.3-1.1
Bone: marrow area0.81.72.01.41.4-1.41.4-1.3-1.3-1.3-1.31.3-1.31.31.31.31.3-1.3-1.31.4-1.4-1.41.40.81.2-1.2
Bone: maximum diameter1.42.52.81.51.6-1.61.7-1.6-1.7-1.7-1.61.7-1.71.71.51.51.7-1.7-1.71.6-1.7-1.71.51.31.30.9
Bone: maximum force0.61.01.70.91.2-1.21.2-1.0-1.0-1.0-1.01.0-1.01.00.90.91.0-1.0-1.01.0-1.3-1.31.00.60.5-0.7
Bone: maximum moment0.50.81.40.91.1-1.11.1-0.9-0.9-0.9-0.90.9-0.90.90.80.80.9-0.9-0.90.9-1.2-1.20.90.50.4-0.7
Mean time between licks in bursts2.83.94.51.92.1-2.12.1-2.1-2.1-2.1-2.12.1-2.12.12.02.02.1-2.1-2.12.0-2.1-2.12.01.51.5-0.1
Mean num. licks in bursts0.00.00.2-0.1-0.30.2-0.10.10.20.20.1-0.20.1-0.1-0.1-0.1-0.10.10.10.00.10.10.0-0.00.20.5
Cd content in liver0.50.50.8-0.5-0.70.9-0.70.70.70.70.7-0.70.7-0.7-0.6-0.6-0.70.70.7-0.80.80.8-0.9-0.0-0.8-0.4
Co content in liver0.10.11.10.20.3-0.20.1-0.1-0.2-0.2-0.20.2-0.20.10.10.10.1-0.1-0.10.1-0.1-0.10.1-0.10.0-1.1
Cu content in liver0.10.10.10.20.3-0.30.3-0.3-0.2-0.2-0.20.2-0.20.20.30.30.2-0.2-0.20.3-0.4-0.40.30.10.10.3
Fe content in liver0.10.10.30.30.2-0.10.2-0.2-0.2-0.2-0.20.2-0.20.20.30.30.2-0.2-0.20.4-0.1-0.10.20.60.40.0
K content in liver7.47.38.22.72.8-2.92.8-2.8-2.8-2.8-2.82.8-2.82.82.72.72.8-2.8-2.82.8-2.8-2.82.72.52.20.3
Mg content in liver2.02.13.11.61.5-1.41.5-1.5-1.5-1.5-1.51.5-1.51.51.61.61.5-1.5-1.51.5-1.4-1.41.41.81.0-0.1
Mn content in liver0.10.12.90.30.2-0.10.1-0.0-0.1-0.1-0.10.2-0.10.10.00.00.1-0.1-0.10.0-0.1-0.1-0.1-0.30.2-1.7
Na content in liver0.80.91.50.91.1-0.91.0-0.9-1.0-1.0-1.01.0-0.91.00.90.91.0-0.9-1.01.0-1.0-1.00.91.20.60.3
Rb content in liver1.01.31.7-1.1-1.31.3-1.21.11.11.11.1-1.11.1-1.1-1.0-1.0-1.11.11.1-1.21.21.2-1.20.1-1.21.2
Se content in liver1.41.72.01.31.2-1.41.4-1.4-1.4-1.4-1.41.3-1.41.41.41.41.4-1.4-1.41.4-1.3-1.31.41.01.20.3
Sr content in liver0.10.10.10.30.2-0.30.2-0.2-0.2-0.2-0.30.2-0.30.20.30.30.2-0.2-0.20.3-0.2-0.20.2-0.3-0.0-0.3
Zn content in liver1.41.63.01.21.1-1.31.3-1.3-1.2-1.2-1.21.2-1.21.21.41.41.2-1.2-1.21.3-1.3-1.31.31.70.71.2
Bone: minimum diameter0.71.41.71.11.2-1.21.3-1.2-1.2-1.2-1.21.3-1.21.21.21.21.2-1.2-1.21.2-1.3-1.31.11.20.90.5
Time in familiar zone, hab. session 17.77.28.4-2.9-2.92.7-2.82.72.82.82.8-2.82.8-2.8-2.7-2.7-2.82.82.8-2.62.72.7-2.6-2.6-2.10.8
Time in novel zone, hab. session 15.35.25.82.32.4-2.42.4-2.4-2.4-2.4-2.42.4-2.42.42.32.32.4-2.4-2.42.3-2.4-2.42.32.11.90.3
Total zone transitions, hab. session 10.10.10.2-0.4-0.30.2-0.30.30.30.30.3-0.30.3-0.3-0.4-0.4-0.30.30.3-0.30.30.3-0.3-0.3-0.30.4
Total locomotion distance, hab. session 10.60.91.1-1.0-0.91.0-1.01.00.90.90.9-0.90.9-0.9-1.1-1.1-0.90.90.9-1.01.01.0-1.1-0.9-0.8-0.1
Locomotion velocity, hab. session 10.20.30.5-0.5-0.50.6-0.60.60.50.50.5-0.50.5-0.5-0.7-0.7-0.50.50.5-0.70.60.6-0.7-0.6-0.5-0.5
Time in familiar zone, hab. session 21.21.21.7-1.3-1.01.1-1.21.21.21.21.2-1.21.2-1.1-1.3-1.3-1.11.11.1-1.01.11.1-1.0-0.9-0.50.8
Time in novel zone, hab. session 23.23.23.91.91.7-1.91.9-1.9-1.9-1.9-1.91.9-1.91.92.02.01.9-1.9-1.91.8-1.8-1.81.81.61.30.2
Total zone transitions, hab. session 20.10.20.50.10.4-0.60.5-0.4-0.3-0.4-0.30.3-0.40.40.30.30.4-0.4-0.40.4-0.6-0.60.4-0.20.30.7
Total locomotion distance, hab. session 20.30.40.9-0.7-0.60.5-0.50.50.60.60.6-0.60.6-0.6-0.6-0.6-0.60.60.5-0.60.50.5-0.6-0.8-0.70.9
Locomotion velocity, hab. session 20.10.10.5-0.4-0.30.1-0.20.20.20.20.3-0.20.2-0.2-0.3-0.3-0.20.20.2-0.30.20.2-0.3-0.6-0.40.7
Novel to familiar place preference ratio0.20.20.4-0.4-0.60.7-0.60.50.40.40.4-0.40.4-0.4-0.5-0.5-0.40.40.4-0.40.60.6-0.40.10.10.6
Novelty place preference0.10.10.4-0.3-0.40.5-0.40.40.30.30.3-0.30.3-0.3-0.4-0.4-0.30.30.3-0.20.50.5-0.20.20.30.6
Time in novel zone, NPP test0.10.10.7-0.3-0.40.5-0.40.30.30.30.3-0.30.3-0.3-0.4-0.4-0.30.30.3-0.20.50.5-0.20.30.20.8
Total zone transitions, NPP test0.10.10.6-0.4-0.10.0-0.20.30.40.30.4-0.30.4-0.3-0.4-0.4-0.30.40.3-0.40.00.0-0.4-0.8-0.7-0.1
Total locomotion distance, NPP test0.20.30.8-0.5-0.40.4-0.40.50.50.50.5-0.50.5-0.5-0.5-0.5-0.50.50.5-0.60.40.4-0.6-0.6-0.90.2
Locomotion velocity, NPP test0.20.20.7-0.5-0.40.4-0.40.50.50.50.5-0.50.5-0.5-0.5-0.5-0.50.50.5-0.60.40.4-0.6-0.5-0.9-0.1
Intraocular pressure0.60.811.5-0.6-0.40.5-0.70.40.40.40.5-0.50.5-0.4-0.4-0.4-0.40.40.4-0.70.90.9-0.60.1-0.83.4
Delta distance traveled before/after self-admin1.11.11.9-1.1-1.31.4-1.11.11.11.11.1-1.11.1-1.1-1.0-1.0-1.11.11.2-1.11.01.0-1.1-0.7-0.7-0.3
Delta ambulatory time before/after self-admin1.51.72.7-1.2-1.51.6-1.31.41.41.41.4-1.41.4-1.4-1.2-1.2-1.41.41.4-1.41.31.3-1.3-0.9-1.00.0
Parametrial fat weight2.95.68.02.82.7-2.52.6-2.3-2.4-2.4-2.42.4-2.42.42.52.52.4-2.4-2.31.9-2.6-2.62.12.51.0-1.7
Pavlov. Cond. lever latency0.20.30.9-0.5-0.20.1-0.40.60.60.50.6-0.60.5-0.5-0.6-0.6-0.50.50.5-0.30.20.2-0.3-0.9-0.1-0.9
Pavlov. Cond. magazine entry latency0.00.00.20.1-0.00.00.0-0.1-0.1-0.1-0.10.1-0.10.10.10.10.1-0.1-0.1-0.10.00.0-0.10.1-0.30.5
Pavlov. Cond. change in total contacts0.10.10.7-0.1-0.30.3-0.20.10.10.10.1-0.10.1-0.1-0.0-0.0-0.10.10.1-0.30.20.2-0.30.2-0.60.8
Pavlov. Cond. index score0.10.10.40.3-0.00.00.1-0.3-0.3-0.3-0.30.3-0.20.20.30.30.2-0.3-0.2-0.00.00.0-0.00.4-0.30.6
Pavlov. Cond. latency score0.10.10.30.4-0.0-0.00.2-0.3-0.3-0.3-0.30.3-0.30.30.50.50.3-0.3-0.30.0-0.0-0.00.00.5-0.20.5
Pavlov. Cond. lever contacts0.10.10.50.0-0.30.4-0.2-0.0-0.0-0.0-0.00.1-0.00.00.10.10.0-0.0-0.0-0.30.40.4-0.30.5-0.30.7
Pavlov. Cond. magazine entry number0.00.00.40.00.20.0-0.00.1-0.0-0.0-0.00.1-0.10.0-0.1-0.10.0-0.0-0.00.2-0.0-0.00.10.20.6-0.5
Pavlov. Cond. intertrial magazine entries1.21.51.9-1.2-1.11.2-1.31.31.31.31.3-1.31.3-1.3-1.4-1.4-1.31.31.3-1.31.21.2-1.3-1.1-1.0-0.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.40.1-0.10.10.0-0.1-0.1-0.1-0.10.1-0.10.10.20.20.1-0.1-0.1-0.10.10.1-0.10.3-0.30.6
Pavlov. Cond. response bias0.10.10.5-0.3-0.40.5-0.40.30.30.30.3-0.30.3-0.3-0.3-0.3-0.30.30.3-0.50.40.4-0.5-0.1-0.70.4
Pavlov. Cond. lever latency0.50.71.1-0.9-0.90.9-1.00.90.80.80.8-0.80.8-0.8-1.0-1.0-0.80.80.8-0.91.01.0-0.8-1.0-0.2-0.2
Pavlov. Cond. magazine entry latency0.60.71.60.71.0-0.91.0-0.9-0.8-0.8-0.80.8-0.80.80.70.70.8-0.8-0.80.8-1.0-1.00.80.80.41.3
Pavlov. Cond. change in total contacts0.00.00.5-0.1-0.20.2-0.00.10.20.20.2-0.20.2-0.2-0.0-0.0-0.20.20.2-0.2-0.0-0.0-0.30.1-0.7-0.1
Pavlov. Cond. index score0.50.60.90.80.8-0.80.9-0.8-0.8-0.8-0.80.8-0.80.80.80.80.8-0.8-0.80.8-1.0-1.00.70.90.30.3
Pavlov. Cond. latency score0.70.81.20.91.0-1.01.0-0.9-0.9-0.9-0.90.9-0.90.90.90.90.9-0.9-0.90.9-1.1-1.10.90.90.50.3
Pavlov. Cond. lever contacts0.81.01.61.01.1-1.11.2-1.0-1.0-1.0-1.01.0-1.01.01.11.11.0-1.0-1.01.0-1.2-1.21.01.10.30.2
Pavlov. Cond. magazine entry number0.20.21.8-0.1-0.40.4-0.40.30.30.30.3-0.30.3-0.3-0.2-0.2-0.30.30.3-0.30.50.5-0.3-0.40.0-1.4
Pavlov. Cond. intertrial magazine entries2.83.74.3-1.8-2.12.0-2.02.02.02.02.0-2.02.0-2.0-1.8-1.8-2.02.02.0-2.02.02.0-1.9-2.0-1.4-1.3
Pavlov. Cond. lever-magazine prob. diff.0.50.61.00.80.9-0.80.9-0.8-0.8-0.8-0.80.8-0.80.80.80.80.8-0.8-0.80.8-1.0-1.00.80.90.40.1
Pavlov. Cond. response bias1.01.32.01.11.2-1.21.3-1.2-1.1-1.2-1.11.1-1.11.11.21.21.1-1.1-1.11.1-1.4-1.41.11.30.30.7
Time in closed arm before self-admin2.42.83.41.61.9-1.61.4-1.8-1.8-1.8-1.81.8-1.81.81.71.71.8-1.8-1.81.7-1.2-1.21.71.41.8-0.5
Time in closed arm after self-admin0.90.91.40.81.2-1.21.0-1.0-1.0-1.0-1.01.0-1.01.00.80.81.0-1.0-1.01.0-1.0-1.01.10.80.80.4
Time in open arm before self-admin2.12.32.9-1.5-1.41.4-1.41.71.71.71.7-1.71.7-1.7-1.6-1.6-1.71.71.7-1.51.31.3-1.5-1.4-1.40.2
Time in open arm after self-admin0.91.01.5-0.7-1.11.2-1.01.01.01.01.0-1.01.0-1.0-0.9-0.9-1.01.01.0-1.21.21.2-1.0-0.7-1.20.4
Bone: periosteal estimation0.91.82.41.41.5-1.51.5-1.4-1.3-1.4-1.31.3-1.31.31.31.31.3-1.3-1.41.4-1.5-1.51.40.91.0-0.5
Bone: periosteal perimeter0.61.11.21.01.1-1.01.1-1.1-1.1-1.1-1.11.1-1.11.11.01.01.1-1.1-1.11.0-1.1-1.10.91.00.70.7
Bone: post-yield work1.21.61.9-1.2-1.31.3-1.31.31.31.31.3-1.31.3-1.3-1.3-1.3-1.31.31.3-1.41.41.4-1.4-1.1-1.10.3
Progressive ratio test 1 active lever presses1.21.21.8-1.3-1.11.1-1.11.21.21.21.2-1.21.2-1.2-1.3-1.3-1.21.21.2-0.91.01.0-0.8-1.0-0.40.5
Progressive ratio test 1 breakpoint1.51.62.2-1.5-1.21.2-1.31.41.41.41.4-1.41.4-1.4-1.4-1.4-1.41.41.3-1.01.21.2-0.9-1.1-0.40.5
Progressive ratio test 1 inactive lever presses0.00.00.10.0-0.2-0.00.1-0.1-0.1-0.1-0.10.1-0.10.10.10.10.1-0.1-0.10.1-0.1-0.10.10.30.2-0.2
Progressive ratio test 2 active lever presses0.60.61.5-1.2-0.70.5-0.80.90.90.90.9-0.90.9-0.9-1.0-1.0-0.90.90.8-0.50.70.7-0.5-0.80.20.5
Progressive ratio test 2 breakpoint0.91.01.8-1.4-0.90.7-1.01.11.11.11.1-1.11.1-1.0-1.2-1.2-1.01.11.0-0.60.90.9-0.7-0.90.10.7
Progressive ratio test 2 inactive lever presses0.20.20.8-0.9-0.40.2-0.40.50.40.40.4-0.40.4-0.4-0.5-0.5-0.40.40.4-0.10.30.3-0.1-0.30.6-0.4
Incentive Sensitization - Responses0.70.71.4-1.2-0.70.7-0.90.90.90.90.9-0.90.9-0.9-1.0-1.0-0.90.90.9-0.70.90.9-0.7-0.6-0.10.4
Incentive Sensitization - Breakpoint0.60.61.1-1.1-0.70.7-0.90.90.80.80.8-0.80.8-0.8-0.9-0.9-0.80.80.8-0.60.90.9-0.7-0.5-0.00.4
Sum of active levers in priming session hrs 5-60.10.10.3-0.3-0.50.3-0.40.40.40.40.4-0.40.4-0.4-0.3-0.3-0.40.40.4-0.20.50.5-0.1-0.20.00.1
Progressive ratio0.91.11.9-1.4-0.91.0-1.11.11.11.01.1-1.01.1-1.0-1.2-1.2-1.01.11.0-1.00.80.8-1.0-1.0-1.10.6
Food seeking constrained by brief footshock0.20.22.3-0.2-0.20.1-0.10.30.40.40.4-0.40.4-0.4-0.4-0.4-0.40.40.4-0.30.10.1-0.4-0.3-1.01.5
Seeking ratio, punishment vs. effort0.50.61.51.20.6-0.90.9-0.8-0.8-0.8-0.80.7-0.80.80.90.90.7-0.8-0.70.7-0.6-0.60.70.70.50.1
Retroperitoneal fat weight1.55.06.91.72.6-2.62.4-2.3-2.2-2.2-2.22.2-2.22.22.22.22.2-2.2-2.22.4-2.6-2.62.42.61.51.1
Reaction time number correct0.20.43.6-0.80.3-0.2-0.10.40.50.40.5-0.50.5-0.4-0.6-0.6-0.40.50.4-0.3-0.2-0.2-0.2-0.2-0.91.9
Reaction time mean minus median0.10.21.00.50.2-0.20.2-0.3-0.3-0.3-0.30.3-0.30.30.40.40.3-0.3-0.30.4-0.1-0.10.50.01.0-0.8
Reaction time mean minus median AUC0.00.10.6-0.1-0.00.0-0.20.10.20.10.2-0.20.1-0.1-0.1-0.1-0.10.10.10.00.30.30.2-0.10.80.3
Reaction time num false alarms0.60.81.7-0.9-0.80.9-1.00.80.80.80.8-0.80.8-0.8-0.8-0.8-0.80.80.8-1.01.11.1-0.9-1.1-1.1-1.3
Reaction time num false alarms AUC1.01.42.1-1.3-1.01.1-1.21.11.11.11.1-1.11.1-1.1-1.1-1.1-1.11.11.1-1.21.11.1-1.2-1.3-1.5-1.5
Reaction time trials correct on left0.20.43.6-0.80.3-0.2-0.10.40.50.40.5-0.50.5-0.4-0.6-0.6-0.40.50.4-0.3-0.2-0.2-0.2-0.2-0.91.9
Reaction time trials on left0.20.33.3-0.80.3-0.3-0.10.30.40.40.4-0.40.4-0.4-0.6-0.6-0.40.40.4-0.3-0.3-0.3-0.2-0.2-0.91.8
Reaction time mean1.11.52.41.31.1-1.21.2-1.3-1.2-1.2-1.21.2-1.31.21.41.41.2-1.3-1.21.4-1.0-1.01.41.11.6-0.4
Reaction time mean AUC0.81.12.01.21.0-1.01.0-1.1-1.1-1.1-1.11.1-1.11.11.21.21.1-1.1-1.11.2-0.8-0.81.21.01.4-0.4
Median of all reaction times1.62.22.91.61.4-1.51.5-1.6-1.5-1.5-1.51.5-1.51.51.61.61.5-1.5-1.51.6-1.2-1.21.61.51.7-0.1
Reaction time omissions0.60.81.70.70.6-0.81.0-0.9-0.9-0.8-0.90.9-0.90.90.80.80.9-0.9-0.91.0-1.1-1.11.00.30.5-1.3
Reaction time false alarm rate0.40.65.1-0.4-0.80.9-0.80.60.50.50.5-0.50.5-0.5-0.5-0.5-0.50.50.5-0.70.90.9-0.7-0.9-0.7-2.2
Reaction time premature initiation rate0.81.01.3-1.1-0.71.1-1.01.11.11.11.1-1.11.1-1.1-1.2-1.2-1.11.11.1-1.00.90.9-1.1-0.6-0.7-0.7
Reaction time premature initiations1.01.42.3-1.5-0.50.8-1.01.31.31.31.3-1.31.3-1.3-1.5-1.5-1.31.31.3-1.10.60.6-1.1-0.8-1.20.5
Std. dev. reaction times0.10.10.90.2-0.1-0.0-0.0-0.0-0.0-0.0-0.0-0.0-0.10.00.20.20.0-0.0-0.00.20.30.30.3-0.40.8-0.9
Reaction time trials completed0.20.33.3-0.80.3-0.3-0.10.30.40.40.4-0.40.4-0.4-0.6-0.6-0.40.40.4-0.3-0.3-0.3-0.2-0.2-0.91.8
Reaction time trials AUC0.30.43.5-0.90.2-0.1-0.30.50.60.50.6-0.60.6-0.5-0.8-0.8-0.50.60.5-0.4-0.1-0.1-0.3-0.2-1.01.9
Run reversals in cocaine runway, females0.80.82.81.00.5-0.50.6-0.9-0.9-0.9-0.90.9-0.90.91.01.00.9-0.9-0.90.8-0.4-0.40.90.81.1-1.7
Run reversals in cocaine runway, males0.10.10.5-0.2-0.40.5-0.40.30.30.30.3-0.30.3-0.3-0.2-0.2-0.30.30.3-0.40.60.6-0.5-0.1-0.10.7
Latency to leave start box in cocaine runway0.91.01.30.91.0-1.00.9-1.0-1.0-1.0-1.01.0-1.01.00.80.81.0-1.0-1.11.1-0.9-0.91.10.61.11.1
Latency to leave start box in cocaine runway, F1.92.02.31.51.4-1.41.5-1.5-1.5-1.5-1.51.5-1.51.51.41.41.5-1.5-1.51.5-1.4-1.41.41.41.30.5
Latency to leave start box in cocaine runway, M0.10.10.8-0.3-0.20.2-0.30.10.10.10.1-0.10.1-0.1-0.2-0.2-0.10.10.10.10.40.40.1-0.80.90.8
Std. dev. time between licks in bursts1.72.02.31.41.5-1.41.4-1.5-1.5-1.5-1.51.5-1.51.51.51.51.5-1.5-1.51.5-1.4-1.41.41.21.3-0.5
Total sessions with >9 infusions0.60.74.50.50.7-0.80.7-0.7-0.7-0.7-0.70.7-0.70.70.60.60.7-0.7-0.71.2-0.7-0.71.10.52.10.3
Short access day 1 total inactive lever presses3.64.08.1-2.1-1.71.7-1.82.12.22.12.2-2.12.2-2.2-2.2-2.2-2.22.22.1-2.21.51.5-2.1-1.4-2.80.3
Short access day 10 total inactive lever presses0.10.10.8-0.10.10.1-0.00.00.00.00.00.00.0-0.00.00.0-0.00.00.0-0.3-0.1-0.1-0.20.7-0.9-0.6
Short access day 1 total infusions0.00.00.2-0.3-0.1-0.10.10.20.20.20.2-0.20.2-0.2-0.3-0.3-0.20.20.10.2-0.2-0.20.2-0.10.40.3
Short access day 10 total infusions0.20.20.60.20.4-0.50.4-0.4-0.4-0.4-0.40.4-0.40.40.30.30.4-0.4-0.40.5-0.4-0.40.50.60.70.3
Short access total infusions0.40.41.30.40.4-0.60.6-0.6-0.6-0.6-0.60.6-0.60.60.60.60.6-0.6-0.60.7-0.6-0.60.80.81.1-0.5
Short access day 1 locomotion0.50.51.1-0.9-0.70.4-0.50.80.80.80.8-0.80.8-0.8-0.9-0.9-0.80.80.8-0.30.40.4-0.5-1.0-0.11.0
Short access day 10 total locomotion0.30.31.30.60.5-0.60.7-0.5-0.4-0.4-0.40.4-0.50.50.30.30.5-0.5-0.50.5-0.9-0.90.50.60.11.1
Short access total locomotion0.00.00.2-0.00.0-0.30.20.10.10.10.1-0.10.1-0.1-0.1-0.1-0.10.10.00.4-0.3-0.30.2-0.00.50.4
One hour access (0.3 mA shock)0.60.71.6-1.3-0.70.5-0.81.01.00.91.0-1.00.9-0.9-1.1-1.1-0.90.90.9-0.60.40.4-0.6-0.7-0.40.3
Compulsive drug intake0.20.20.70.40.4-0.40.4-0.3-0.3-0.3-0.30.3-0.20.30.20.20.3-0.3-0.30.0-0.7-0.70.00.3-0.7-0.8
One hour access (shock baseline)1.41.63.2-1.8-1.10.9-1.31.41.41.41.4-1.41.4-1.4-1.5-1.5-1.41.41.4-0.91.01.0-0.9-1.3-0.21.0
Social response proportion0.30.42.20.30.4-0.60.5-0.3-0.3-0.4-0.30.3-0.40.40.20.20.4-0.4-0.40.9-0.7-0.70.6-0.61.5-1.3
Social responses0.50.61.3-1.0-0.50.5-0.80.80.90.90.9-0.90.9-0.9-0.9-0.9-0.90.90.9-0.60.50.5-0.7-1.1-0.4-0.1
Social time2.43.14.4-1.9-1.71.6-1.81.91.81.81.8-1.81.8-1.8-2.0-2.0-1.81.81.8-1.61.71.7-1.8-2.1-1.3-0.7
Soleus weight0.41.31.91.11.3-1.21.2-1.1-1.1-1.1-1.11.1-1.21.11.11.11.1-1.1-1.11.1-1.2-1.21.10.41.0-1.4
Bone: stiffness0.00.11.00.00.2-0.20.1-0.0-0.0-0.0-0.00.0-0.00.0-0.0-0.00.0-0.0-0.00.0-0.3-0.3-0.1-0.3-0.2-1.0
Tibialis anterior weight0.72.53.1-1.6-1.61.8-1.71.71.61.61.6-1.61.6-1.6-1.7-1.7-1.61.61.6-1.71.71.7-1.7-0.7-1.40.9
Time to tail flick, vehicle, before self-admin1.61.62.61.41.1-1.21.2-1.3-1.4-1.3-1.41.3-1.31.31.31.31.3-1.4-1.41.3-0.9-0.91.61.31.60.0
Time to tail flick, vehicle, after self-admin1.92.13.41.41.4-1.41.3-1.5-1.5-1.5-1.51.5-1.51.51.51.51.5-1.5-1.51.6-1.1-1.11.51.31.8-0.9
Time to tail flick, test, before self-admin0.10.11.4-0.2-0.1-0.2-0.1-0.1-0.1-0.1-0.10.1-0.10.1-0.0-0.00.1-0.1-0.10.40.10.10.4-0.11.2-0.2
Time to tail flick, test, after self-admin0.10.10.5-0.4-0.60.5-0.50.20.20.20.1-0.20.2-0.2-0.3-0.3-0.20.20.2-0.30.70.70.10.10.7-0.6
Delta time to tail flick, vehicle, before/after SA0.30.30.7-0.7-0.50.5-0.60.60.60.60.6-0.60.6-0.6-0.6-0.6-0.60.60.6-0.30.50.5-0.7-0.5-0.2-0.9
Delta time to tail flick, test, before/after SA0.00.00.10.30.00.00.1-0.2-0.2-0.2-0.20.2-0.20.20.20.20.2-0.2-0.2-0.20.00.00.00.4-0.3-0.4
Tibia length0.41.01.51.11.2-1.11.0-1.0-1.0-1.0-1.01.0-1.01.01.01.01.0-1.0-1.01.0-1.0-1.00.91.00.8-0.9
Ambulatory time before self-admin0.60.71.10.70.7-0.70.9-0.8-0.8-0.8-0.80.8-0.80.80.90.90.8-0.8-0.80.8-1.1-1.10.70.80.5-0.8
Ambulatory time after self-admin0.10.10.7-0.1-0.50.60.10.20.20.20.2-0.20.2-0.20.00.0-0.20.20.2-0.1-0.4-0.4-0.10.3-0.0-0.8
Bone: tissue strength0.60.61.30.60.8-0.90.8-0.7-0.7-0.7-0.70.7-0.70.70.60.60.7-0.7-0.71.0-0.9-0.90.80.20.8-1.1
Total heroin consumption0.60.71.1-0.6-0.90.7-0.50.80.90.90.8-0.90.8-0.9-0.8-0.8-0.90.90.9-0.90.30.3-0.9-1.0-1.1-0.7
Bone: trabecular number0.20.47.8-0.4-0.40.1-0.00.00.20.20.2-0.20.2-0.1-0.1-0.1-0.20.20.1-0.1-0.1-0.1-0.10.3-0.52.8
Bone: trabecular spacing0.00.00.50.1-0.0-0.00.00.00.00.00.0-0.00.0-0.00.10.1-0.00.00.0-0.0-0.1-0.1-0.00.1-0.2-0.7
Bone: trabecular thickness0.00.10.90.10.3-0.10.10.0-0.1-0.1-0.10.1-0.10.1-0.1-0.10.1-0.1-0.1-0.0-0.2-0.2-0.0-0.2-0.1-1.0
Bone: trabecular tissue density0.00.00.3-0.10.1-0.10.00.00.10.00.1-0.10.0-0.0-0.1-0.1-0.00.00.00.2-0.1-0.10.2-0.20.5-0.3
Water consumed over 24 hours2.02.43.11.51.6-1.51.7-1.6-1.6-1.6-1.61.6-1.61.61.61.61.6-1.6-1.61.6-1.8-1.81.61.51.3-0.2
Number of responses in last shaping day0.10.11.6-0.60.0-0.0-0.20.30.30.30.3-0.30.3-0.3-0.3-0.3-0.30.30.3-0.1-0.2-0.2-0.3-0.2-0.3-1.2