Hub : Genes

Slc1a2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative polyA	NM_001035233.2	0.02	0.03	6.4e-03	0.01	0.01	0.01	0.01	7.5e-03	2.0e-02	2.9e-02	1.3e-02
2	Liver	alternative polyA	NM_017215.3	0.02	0.03	6.2e-03	0.01	0.01	0.01	0.01	8.4e-03	2.2e-02	4.3e-02	2.6e-02
3	Liver	isoform ratio	NM_001302089.2	0.03	0.03	3.6e-03	0.01	0.01	0.01	0.01	1.3e-02	2.0e-02	1.4e-02	2.3e-02
4	Adipose	gene expression	Slc1a2	0.07	0.06	7.9e-07	0.04	0.04	0.02	0.04	1.1e-05	8.6e-06	1.4e-03	1.8e-05
5	Liver	isoform ratio	NM_001035233.2	0.03	0.03	3.2e-03	0.01	0.01	0.01	0.01	1.6e-02	1.8e-02	1.8e-02	3.2e-02
6	pVTA	mRNA stability	Slc1a2	0.06	0.05	2.9e-03	0.03	0.04	0.01	0.02	1.5e-02	1.2e-02	7.8e-02	5.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.7	1.1	1.4	-1.0	1.0	1.2	-1.1	-1.1	1.1
Area under the delay curve	0.4	0.4	0.5	0.5	-0.5	-0.7	0.7	0.7	-0.7
BMI with tail	0.3	0.8	1.0	-1.0	1.0	1.0	-0.8	-1.0	0.7
BMI without tail	0.5	1.1	1.3	-1.0	1.0	1.1	-1.1	-1.0	1.0
Body weight	0.7	3.0	3.7	-1.9	1.9	1.9	-1.4	-1.8	1.2
Weight adjusted by age	2.3	2.6	2.8	1.7	-1.7	-1.6	1.6	1.6	-1.5
Bone surface	0.5	0.9	1.1	-1.0	1.0	1.0	-0.9	-1.0	0.8
Bone volume	1.6	2.7	2.9	-1.6	1.6	1.7	-1.6	-1.7	1.6
Breakpoint value in progressive ratio session	1.4	1.6	1.7	1.3	-1.3	-1.2	1.2	1.3	-1.1
Number of licking bursts	0.1	0.1	0.1	-0.3	0.3	0.3	-0.2	-0.4	0.2
Context. condit. distance diff. score	2.2	2.6	2.9	-1.6	1.6	1.6	-1.5	-1.6	1.7
Locomotion velocity, session 1	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.0	0.2	0.0
Locomotion distance, session 1	0.1	0.1	0.2	-0.1	0.1	0.2	-0.4	-0.2	0.4
Locomotion velocity, session 2	0.0	0.0	0.0	0.2	-0.2	-0.2	0.1	0.2	-0.1
Locomotion distance, session 2	0.4	0.5	0.6	-0.6	0.6	0.7	-0.8	-0.7	0.8
Locomotion velocity, session 3	0.1	0.2	0.3	-0.4	0.4	0.4	-0.5	-0.4	0.5
Locomotion distance, session 3	0.3	0.3	0.4	-0.6	0.6	0.5	-0.6	-0.5	0.6
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.2	0.2	0.3
Stereotopy head waving duration, day 3	0.3	0.4	0.6	-0.5	0.5	0.5	-0.7	-0.5	0.8
Locomotion velocity, session 7	0.1	0.1	0.3	-0.4	0.4	0.1	-0.5	-0.1	0.6
Locomotion distance, session 7	0.2	0.3	0.3	0.5	-0.5	-0.6	0.5	0.6	-0.5
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.2	0.2	0.0	-0.0	-0.0	0.1
Stereotopy head waving duration, day 7	0.0	0.0	0.0	0.0	-0.0	-0.1	0.0	0.1	-0.0
Locomotion velocity, session 8	0.7	0.8	1.0	-0.8	0.8	0.9	-1.0	-0.9	1.0
Locomotion distance, session 8	3.0	4.4	4.9	-2.0	2.0	2.1	-2.1	-2.1	2.2
Degree of sensitization distance	0.5	0.5	0.6	0.7	-0.7	-0.7	0.8	0.7	-0.7
Degree of sensitization stereotypy	0.0	0.0	0.0	0.0	-0.0	-0.1	0.2	0.1	-0.2
Conditioned locomotion	4.3	5.0	5.6	2.2	-2.2	-2.2	2.4	2.1	-2.3
Cocaine response after cond. corrected	2.1	2.4	2.5	1.6	-1.6	-1.6	1.5	1.5	-1.5
Cocaine response after cond. not corrected	0.5	0.5	0.6	0.7	-0.7	-0.7	0.8	0.6	-0.8
Cocaine response before conditioning	4.6	5.6	6.0	-2.4	2.4	2.4	-2.2	-2.4	2.2
Saline control response	0.9	1.2	1.4	-1.1	1.1	1.1	-1.0	-1.2	1.0
Bone: connectivity density	0.5	0.7	0.9	-0.8	0.8	1.0	-0.8	-0.9	0.8
Bone: cortical apparent density	0.1	0.1	0.1	0.2	-0.2	-0.2	0.3	0.3	-0.3
Bone: cortical area	0.1	0.1	0.2	-0.5	0.5	0.4	-0.1	-0.4	-0.1
Bone: cortical porosity	0.5	0.6	0.7	0.7	-0.7	-0.8	0.8	0.8	-0.7
Bone: cortical porosity	0.3	0.4	0.4	0.5	-0.5	-0.6	0.6	0.6	-0.6
Bone: cortical thickness	0.0	0.0	0.1	-0.0	0.0	-0.0	0.2	0.1	-0.4
Bone: cortical thickness	4.2	4.9	6.3	2.1	-2.1	-2.1	2.4	2.1	-2.5
Bone: cortical tissue density	0.0	0.0	0.1	0.1	-0.1	-0.1	0.2	0.2	-0.2
Condit. Reinf. active minus inactive responses	0.8	0.9	1.0	-1.0	1.0	0.9	-1.0	-0.9	1.0
Condit. Reinf. active-inactive response ratio	1.9	2.0	2.5	-1.6	1.6	1.4	-1.3	-1.4	1.2
Condit. Reinf. active responses	0.2	0.3	0.3	-0.5	0.5	0.4	-0.5	-0.4	0.5
Condit. Reinf. inactive responses	0.4	0.5	0.6	0.8	-0.8	-0.7	0.6	0.7	-0.5
Incentive salience index mean	0.8	1.0	1.1	-1.0	1.0	0.9	-1.0	-0.9	1.0
Condit. Reinf. lever presses	0.7	1.0	1.0	-1.0	1.0	1.0	-1.0	-1.0	0.9
Condit. Reinf. active minus inactive responses	1.1	1.4	1.7	-1.2	1.2	1.1	-1.2	-1.0	1.3
Condit. Reinf. active-inactive response ratio	3.0	3.1	3.4	-1.8	1.8	1.7	-1.8	-1.6	1.8
Condit. Reinf. active responses	0.8	1.1	1.2	-1.1	1.1	1.0	-1.0	-0.9	1.1
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.1	0.1	0.0	0.1	-0.1	-0.1
Condit. Reinf. lever presses	0.5	0.6	0.8	-0.8	0.8	0.8	-0.8	-0.7	0.9
Condit. Reinf. lever reinforcers received	0.9	1.2	1.4	-1.1	1.1	1.0	-1.1	-1.0	1.2
Conditioned reinforcement - actives	3.5	3.5	3.8	-1.9	1.9	1.8	-1.9	-1.7	1.9
Conditioned reinforcement - inactives	8.6	9.6	10.8	-3.0	3.0	3.2	-3.3	-3.0	3.1
Conditioned locomotion	3.0	3.6	4.7	-2.2	2.2	1.8	-1.9	-1.5	1.7
Patch foraging indifference point 0 sec	0.2	0.3	0.3	0.6	-0.6	-0.5	0.5	0.5	-0.4
Patch foraging indifference point AUC	1.4	1.6	1.9	1.4	-1.4	-1.3	1.1	1.3	-1.1
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.1	-0.1	-0.2	0.2	0.1	-0.3
Delay disc. indifference point, 16s delay	2.3	2.3	2.6	1.4	-1.4	-1.5	1.5	1.6	-1.6
Delay disc. indifference point, 2s delay	0.5	0.6	0.7	0.8	-0.8	-0.8	0.7	0.8	-0.7
Delay disc. indifference point, 24s delay	0.4	0.4	0.5	0.5	-0.5	-0.7	0.6	0.7	-0.5
Delay disc. indifference point, 4s delay	0.4	0.4	0.5	0.6	-0.6	-0.6	0.6	0.6	-0.7
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.4	0.4	0.3	-0.3	-0.3	0.4
Indifference point function ln k	0.8	1.1	1.6	-1.3	1.3	1.1	-0.7	-1.1	0.5
Indifference point function log k	0.8	1.1	1.6	-1.3	1.3	1.1	-0.7	-1.1	0.5
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	0.4	-0.4	-0.4	0.3	0.4	-0.3
Patch foraging total patch changes 12 sec	0.2	0.2	0.4	-0.2	0.2	0.4	-0.6	-0.4	0.6
Patch foraging total patch changes 18 sec	0.5	0.6	0.7	0.8	-0.8	-0.8	0.7	0.9	-0.6
Patch foraging total patch changes 24 sec	1.0	1.2	1.3	1.1	-1.1	-1.1	1.1	1.2	-0.9
Patch foraging total patch changes 6 sec	0.2	0.3	0.4	0.6	-0.6	-0.6	0.3	0.6	-0.2
Patch foraging time to switch 0 sec	0.0	0.0	0.1	0.1	-0.1	-0.0	-0.2	0.0	0.3
Patch foraging water rate 0 sec	0.0	0.0	0.2	-0.2	0.2	0.0	0.3	-0.0	-0.4
Patch foraging water rate 12 sec	0.3	0.4	0.8	0.4	-0.4	-0.5	0.9	0.5	-0.9
Patch foraging water rate 18 sec	0.7	0.9	1.2	-1.1	1.1	1.1	-0.7	-1.1	0.7
Patch foraging water rate 24 sec	0.3	0.4	0.8	0.4	-0.4	-0.6	0.8	0.6	-0.9
Patch foraging water rate 6 sec	0.0	0.1	0.2	0.0	-0.0	0.0	0.4	-0.0	-0.5
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	-0.3	0.3	0.7	-0.5	-0.7	0.3
Distance traveled before self-admin	0.7	0.7	1.0	-1.0	1.0	0.9	-0.8	-0.9	0.6
Distance traveled after self-admin	0.4	0.5	0.6	-0.8	0.8	0.7	-0.7	-0.6	0.6
Extensor digitorum longus weight	0.4	1.4	1.6	1.1	-1.1	-1.2	1.2	1.1	-1.3
Bone: elastic displacement	2.0	2.3	2.3	1.5	-1.5	-1.5	1.5	1.5	-1.5
Bone: elastic work	1.4	1.8	2.1	1.3	-1.3	-1.3	1.4	1.3	-1.5
Bone: endosteal estimation	0.2	0.4	0.7	0.6	-0.6	-0.5	0.8	0.5	-0.9
Bone: endosteal perimeter	0.3	0.6	0.8	-0.8	0.8	0.9	-0.6	-0.9	0.6
Epididymis fat weight	0.8	1.8	2.2	-1.5	1.5	1.3	-1.3	-1.4	1.3
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.3	0.3	0.2	-0.1	-0.3	0.2
Delta time in open arm before/after self-admin	0.6	0.6	0.8	0.6	-0.6	-0.8	0.7	0.9	-0.9
Diff in mean of infusions in LGA sessions	0.4	0.5	0.6	0.7	-0.7	-0.6	0.6	0.7	-0.8
Delay discount exponential model param	0.5	0.5	0.6	-0.6	0.6	0.7	-0.7	-0.8	0.7
Extinction: sum of active levers before priming	0.5	0.5	0.6	-0.8	0.8	0.6	-0.7	-0.6	0.8
Active lever presses in extinction session 6	0.6	0.6	0.8	-0.7	0.7	0.9	-0.7	-0.7	0.9
Bone: final force	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1	0.1	-0.2
Bone: final moment	0.1	0.2	0.2	0.3	-0.3	-0.4	0.4	0.5	-0.5
Food consumed during 24 hour testing period	6.9	8.3	8.8	-3.0	3.0	2.9	-2.9	-2.8	2.8
Glucose	2.0	3.0	3.6	-1.6	1.6	1.7	-1.8	-1.7	1.9
Heart weight	0.5	0.7	1.0	0.8	-0.8	-0.8	1.0	0.8	-0.9
Delay discount hyperbolic model param	0.4	0.4	0.5	-0.6	0.6	0.7	-0.6	-0.7	0.7
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.4	0.4	0.4	-0.2	-0.2	0.2
Intermittent access intake escalation	0.4	0.4	0.6	-0.8	0.8	0.6	-0.5	-0.4	0.5
Intermittent access intake escalation 2	2.3	2.2	2.8	-1.7	1.7	1.5	-1.5	-1.3	1.3
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.0	-0.0	-0.0	0.2	0.1	-0.3
Intermitt. access day 15 inactive lever presses	3.5	3.8	4.8	-2.2	2.2	2.0	-1.9	-1.8	1.7
Intermitt. access escalation Index	0.0	0.0	0.0	-0.0	0.0	0.0	-0.1	0.0	0.2
Intermittent access day 1 total infusions	3.9	4.5	4.7	-2.1	2.1	2.1	-2.2	-2.0	2.1
Intermittent access day 15 total infusions	4.9	5.5	6.0	-2.5	2.5	2.4	-2.4	-2.1	2.3
Intermittent access terminal intake (last 3 days)	6.2	6.8	7.3	-2.7	2.7	2.7	-2.6	-2.4	2.5
Intermittent access total infusions	6.1	6.8	7.3	-2.7	2.7	2.7	-2.7	-2.4	2.5
Intermittent access day 1 locomotion	1.8	1.9	2.2	-1.5	1.5	1.4	-1.4	-1.2	1.3
Intermittent access day 15 total locomotion	2.8	3.0	3.7	-1.9	1.9	1.7	-1.7	-1.4	1.7
Intermittent access total locomotion	3.0	3.5	4.3	-2.1	2.1	1.8	-1.9	-1.6	1.7
Intermittent access standard deviation	6.8	7.2	8.3	-2.9	2.9	2.8	-2.6	-2.4	2.5
Left kidney weight	0.8	2.2	2.7	-1.6	1.6	1.5	-1.2	-1.6	1.1
Right kidney weight	0.7	2.1	2.7	-1.6	1.6	1.4	-1.3	-1.4	1.2
Cocaine induced anxiety	0.2	0.3	0.4	-0.5	0.5	0.6	-0.5	-0.6	0.3
Post-drug Anxiety	0.0	0.0	0.0	0.1	-0.1	-0.0	0.0	-0.1	-0.2
Baseline Anxiety	2.4	2.5	2.8	1.6	-1.6	-1.7	1.6	1.6	-1.6
Tail length	0.3	1.0	1.2	-1.0	1.0	1.1	-1.0	-1.0	1.0
Length with tail	0.3	1.3	1.7	-1.3	1.3	1.3	-0.8	-1.3	0.6
Length without tail	0.3	0.6	0.8	-0.9	0.9	0.9	-0.4	-0.9	0.3
Times rat made contact with spout	0.1	0.2	0.2	-0.5	0.5	0.3	-0.4	-0.3	0.3
Lifetime Intake	6.3	7.2	7.7	-2.8	2.8	2.7	-2.7	-2.6	2.5
Liver weight, left	0.1	0.2	0.3	-0.4	0.4	0.4	-0.5	-0.5	0.6
Liver weight, right	1.1	1.8	2.0	-1.4	1.4	1.3	-1.3	-1.4	1.2
Locomotor activity	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.1	-0.1	0.2
Locomotor testing distance	1.0	1.6	1.9	-1.3	1.3	1.2	-1.2	-1.3	1.4
Locomotor testing rearing	0.1	0.1	0.2	-0.2	0.2	0.3	-0.3	-0.3	0.5
Locomotion in novel chamber	0.7	0.9	1.0	-0.9	0.9	1.0	-0.9	-1.0	0.8
Locomotion in novel chamber post-restriction	1.4	1.7	1.8	1.2	-1.2	-1.3	1.3	1.3	-1.3
Fecal boli incidents, locomotor time 1	10.0	10.9	11.5	3.2	-3.2	-3.3	3.4	3.3	-3.3
Change in fecal boli incidents, locomotor task	8.0	7.5	8.1	-2.7	2.7	2.7	-2.8	-2.7	2.8
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	0.5	-0.5	-0.5	0.4	0.5	-0.2
Bouts of movement, locomotor time 1	1.3	1.4	1.9	1.1	-1.1	-1.2	1.2	1.2	-1.4
Total resting periods, locomotor time 1	1.2	1.3	1.7	1.0	-1.0	-1.1	1.2	1.1	-1.3
Rest time, locomotor task time 1	0.7	0.8	0.9	0.8	-0.8	-0.9	0.9	0.9	-0.9
Distance moved, locomotor task time 1	2.5	2.7	3.1	-1.5	1.5	1.8	-1.7	-1.8	1.5
Vertical activity count, locomotor time 1	0.2	0.2	0.2	-0.4	0.4	0.4	-0.4	-0.4	0.4
Time >=10cm from walls, locomotor time 2	5.8	6.2	6.5	-2.4	2.4	2.5	-2.5	-2.5	2.5
Bouts of movement, locomotor time 2	0.1	0.1	0.1	0.2	-0.2	-0.4	0.3	0.4	-0.2
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.1	-0.1	-0.3	0.2	0.3	-0.1
Rest time, locomotor task time 2	1.9	2.2	2.5	1.5	-1.5	-1.5	1.6	1.5	-1.4
Distance moved, locomotor task time 2	3.9	4.6	5.2	-2.1	2.1	2.3	-2.2	-2.3	1.8
Vertical activity count, locomotor time 2	2.5	2.7	2.9	-1.6	1.6	1.7	-1.7	-1.7	1.5
Light reinforcement 1	0.3	0.5	0.8	-0.5	0.5	0.9	-0.7	-0.8	0.6
Light reinforcement 2	0.0	0.1	0.2	-0.2	0.2	0.4	-0.2	-0.2	0.0
Bone: marrow area	0.2	0.4	0.7	0.6	-0.6	-0.5	0.8	0.5	-0.8
Bone: maximum diameter	0.1	0.2	0.4	-0.6	0.6	0.6	-0.3	-0.6	0.1
Bone: maximum force	0.0	0.1	0.1	-0.3	0.3	0.3	-0.1	-0.3	0.0
Bone: maximum moment	0.0	0.1	0.1	0.1	-0.1	-0.1	0.3	0.2	-0.4
Mean time between licks in bursts	0.9	1.2	1.6	1.0	-1.0	-1.1	1.3	1.1	-1.2
Mean num. licks in bursts	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2	-0.1	0.3
Cd content in liver	1.6	1.8	2.4	-1.2	1.2	1.3	-1.5	-1.3	1.5
Co content in liver	1.8	2.1	2.3	1.4	-1.4	-1.5	1.4	1.5	-1.4
Cu content in liver	0.6	0.7	1.2	0.7	-0.7	-0.6	1.0	0.6	-1.1
Fe content in liver	1.2	1.4	2.0	1.2	-1.2	-1.4	1.0	1.4	-0.9
K content in liver	1.8	1.8	2.1	1.3	-1.3	-1.4	1.3	1.4	-1.5
Mg content in liver	2.0	2.1	2.7	1.4	-1.4	-1.4	1.5	1.4	-1.6
Mn content in liver	1.7	2.0	2.2	1.5	-1.5	-1.3	1.4	1.3	-1.4
Na content in liver	0.1	0.1	0.2	0.3	-0.3	-0.4	0.4	0.4	-0.5
Rb content in liver	1.5	1.8	2.1	1.4	-1.4	-1.5	1.2	1.5	-1.2
Se content in liver	4.3	5.2	5.8	2.3	-2.3	-2.2	2.3	2.2	-2.4
Sr content in liver	0.2	0.2	0.5	0.3	-0.3	-0.2	0.6	0.2	-0.7
Zn content in liver	0.2	0.2	0.2	0.4	-0.4	-0.4	0.4	0.4	-0.4
Bone: minimum diameter	0.5	0.9	1.2	-1.1	1.1	1.0	-0.7	-1.1	0.5
Time in familiar zone, hab. session 1	0.4	0.4	0.5	0.7	-0.7	-0.6	0.7	0.6	-0.6
Time in novel zone, hab. session 1	0.8	0.8	0.9	-1.0	1.0	0.9	-0.9	-0.9	0.7
Total zone transitions, hab. session 1	2.5	3.5	3.9	-1.8	1.8	1.8	-1.9	-1.8	2.0
Total locomotion distance, hab. session 1	1.0	1.5	1.7	-1.3	1.3	1.1	-1.2	-1.1	1.3
Locomotion velocity, hab. session 1	0.7	1.0	1.2	-1.0	1.0	1.0	-1.0	-1.0	1.1
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.3	0.3	0.3	-0.2	-0.3	0.0
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.1	-0.1	-0.1	0.0	0.1	0.1
Total zone transitions, hab. session 2	2.2	2.9	3.0	-1.6	1.6	1.7	-1.7	-1.7	1.7
Total locomotion distance, hab. session 2	0.1	0.1	0.1	-0.4	0.4	0.3	-0.3	-0.3	0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.1	-0.3	0.3	0.3	-0.2	-0.3	0.2
Novel to familiar place preference ratio	0.9	1.0	1.1	-1.0	1.0	0.9	-1.0	-0.9	1.0
Novelty place preference	0.9	0.9	1.0	-1.0	1.0	0.9	-1.0	-0.9	1.0
Time in novel zone, NPP test	0.6	0.6	0.7	-0.8	0.8	0.7	-0.8	-0.7	0.8
Total zone transitions, NPP test	0.6	0.8	1.0	1.0	-1.0	-1.0	0.7	1.0	-0.6
Total locomotion distance, NPP test	0.3	0.5	0.6	0.7	-0.7	-0.7	0.7	0.7	-0.5
Locomotion velocity, NPP test	0.2	0.3	0.3	0.5	-0.5	-0.6	0.5	0.6	-0.4
Intraocular pressure	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.2	0.1	0.3
Delta distance traveled before/after self-admin	0.3	0.3	0.5	0.5	-0.5	-0.6	0.5	0.7	-0.4
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	0.3	-0.3	-0.5	0.4	0.6	-0.4
Parametrial fat weight	1.1	2.2	2.5	-1.4	1.4	1.5	-1.5	-1.6	1.5
Pavlov. Cond. lever latency	0.5	0.6	0.8	0.7	-0.7	-0.8	0.9	0.8	-0.9
Pavlov. Cond. magazine entry latency	1.2	1.6	1.8	-1.2	1.2	1.2	-1.3	-1.2	1.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.2	-0.2	-0.2	0.3	0.2	-0.4
Pavlov. Cond. index score	0.5	0.6	0.7	-0.8	0.8	0.8	-0.8	-0.8	0.8
Pavlov. Cond. latency score	0.6	0.7	0.8	-0.8	0.8	0.9	-0.9	-0.9	0.9
Pavlov. Cond. lever contacts	0.3	0.4	0.4	-0.6	0.6	0.6	-0.6	-0.6	0.6
Pavlov. Cond. magazine entry number	1.2	1.5	1.8	1.2	-1.2	-1.2	1.3	1.2	-1.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.3	-0.3	-0.3	0.2	0.3	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.6	-0.6	0.6	0.7	-0.8	-0.7	0.8
Pavlov. Cond. response bias	0.9	1.1	1.3	-1.0	1.0	1.0	-1.1	-1.0	1.1
Pavlov. Cond. lever latency	2.0	2.7	3.6	1.6	-1.6	-1.6	1.8	1.5	-1.9
Pavlov. Cond. magazine entry latency	1.1	1.2	1.4	-1.1	1.1	1.1	-1.2	-1.0	1.2
Pavlov. Cond. change in total contacts	0.9	1.2	1.4	-1.1	1.1	1.1	-1.2	-1.0	1.2
Pavlov. Cond. index score	1.9	2.5	2.9	-1.6	1.6	1.5	-1.7	-1.4	1.7
Pavlov. Cond. latency score	2.4	3.0	3.4	-1.7	1.7	1.7	-1.8	-1.6	1.9
Pavlov. Cond. lever contacts	2.1	2.9	3.6	-1.7	1.7	1.7	-1.8	-1.5	1.9
Pavlov. Cond. magazine entry number	0.5	0.7	0.8	0.8	-0.8	-0.8	0.9	0.7	-0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	0.4	-0.4	-0.5	0.3	0.5	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	2.3	-1.4	1.4	1.4	-1.5	-1.3	1.5
Pavlov. Cond. response bias	1.7	2.3	2.9	-1.5	1.5	1.5	-1.6	-1.3	1.7
Time in closed arm before self-admin	0.5	0.6	0.7	-0.7	0.7	0.9	-0.9	-0.8	0.8
Time in closed arm after self-admin	0.4	0.4	0.6	-0.7	0.7	0.7	-0.6	-0.7	0.6
Time in open arm before self-admin	0.6	0.7	0.9	0.9	-0.9	-0.8	0.9	0.7	-0.7
Time in open arm after self-admin	1.8	1.9	2.5	1.3	-1.3	-1.5	1.3	1.6	-1.3
Bone: periosteal estimation	0.1	0.1	0.4	0.1	-0.1	-0.1	0.5	0.1	-0.6
Bone: periosteal perimeter	1.2	1.9	2.2	-1.5	1.5	1.5	-1.2	-1.5	1.1
Bone: post-yield work	0.0	0.0	0.0	0.1	-0.1	-0.1	0.2	0.1	-0.1
Progressive ratio test 1 active lever presses	4.0	4.2	4.8	-1.9	1.9	2.2	-2.1	-2.1	2.0
Progressive ratio test 1 breakpoint	3.6	3.7	4.4	-1.8	1.8	2.1	-1.9	-2.0	1.8
Progressive ratio test 1 inactive lever presses	2.4	2.6	2.8	-1.6	1.6	1.7	-1.6	-1.6	1.6
Progressive ratio test 2 active lever presses	3.0	3.3	3.7	-1.9	1.9	1.8	-1.9	-1.7	1.7
Progressive ratio test 2 breakpoint	3.5	3.9	4.4	-2.0	2.0	2.0	-2.1	-1.9	1.9
Progressive ratio test 2 inactive lever presses	3.9	4.5	5.1	-2.3	2.3	2.2	-2.2	-2.0	1.9
Incentive Sensitization - Responses	1.4	1.4	1.8	-1.2	1.2	1.2	-1.4	-1.1	1.1
Incentive Sensitization - Breakpoint	1.2	1.2	1.6	-1.1	1.1	1.1	-1.3	-1.0	1.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	0.5	-0.5	-0.5	0.6	0.6	-0.6
Progressive ratio	0.5	0.6	0.7	-0.8	0.8	0.8	-0.8	-0.8	0.7
Food seeking constrained by brief footshock	1.4	1.7	1.9	-1.2	1.2	1.4	-1.3	-1.4	1.2
Seeking ratio, punishment vs. effort	0.2	0.2	0.2	0.5	-0.5	-0.4	0.5	0.4	-0.4
Retroperitoneal fat weight	8.9	29.4	31.5	-5.5	5.5	5.5	-5.3	-5.6	5.2
Reaction time number correct	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.1	0.0	0.0
Reaction time mean minus median	0.5	0.6	0.9	-0.7	0.7	0.7	-0.9	-0.7	1.0
Reaction time mean minus median AUC	0.3	0.4	0.6	-0.6	0.6	0.6	-0.7	-0.6	0.7
Reaction time num false alarms	1.6	2.2	2.5	1.6	-1.6	-1.5	1.4	1.5	-1.4
Reaction time num false alarms AUC	2.6	3.6	3.8	1.9	-1.9	-1.9	1.8	1.9	-1.8
Reaction time trials correct on left	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.1	0.0	0.0
Reaction time trials on left	0.0	0.0	0.0	0.2	-0.2	-0.1	0.0	0.1	-0.1
Reaction time mean	0.2	0.3	0.3	-0.5	0.5	0.5	-0.6	-0.6	0.6
Reaction time mean AUC	0.3	0.4	0.5	-0.5	0.5	0.6	-0.7	-0.7	0.6
Median of all reaction times	0.4	0.5	0.6	-0.6	0.6	0.7	-0.7	-0.8	0.7
Reaction time omissions	0.8	1.1	1.2	1.1	-1.1	-1.1	1.0	1.1	-0.9
Reaction time false alarm rate	2.8	3.9	4.0	2.0	-2.0	-2.0	2.0	2.0	-1.9
Reaction time premature initiation rate	0.2	0.2	0.3	0.5	-0.5	-0.5	0.5	0.5	-0.4
Reaction time premature initiations	0.1	0.2	0.2	0.4	-0.4	-0.4	0.4	0.4	-0.3
Std. dev. reaction times	0.0	0.0	0.1	-0.1	0.1	0.1	-0.2	-0.1	0.2
Reaction time trials completed	0.0	0.0	0.0	0.2	-0.2	-0.1	0.0	0.1	-0.1
Reaction time trials AUC	0.0	0.0	0.0	-0.0	0.0	0.1	-0.2	-0.1	0.2
Run reversals in cocaine runway, females	0.1	0.1	0.2	-0.4	0.4	0.3	-0.2	-0.3	0.2
Run reversals in cocaine runway, males	4.1	4.0	4.1	2.0	-2.0	-2.0	2.0	2.0	-1.9
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.2	-0.2	-0.2	0.3	0.2	-0.2
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.2	0.2	0.1	-0.1	-0.1	0.2
Latency to leave start box in cocaine runway, M	0.4	0.3	0.5	0.5	-0.5	-0.5	0.6	0.5	-0.7
Std. dev. time between licks in bursts	0.8	0.9	1.0	1.0	-1.0	-0.9	1.0	0.9	-0.9
Total sessions with >9 infusions	1.9	2.1	2.2	-1.5	1.5	1.5	-1.4	-1.4	1.3
Short access day 1 total inactive lever presses	0.7	0.8	0.9	-0.8	0.8	0.9	-0.9	-0.9	1.0
Short access day 10 total inactive lever presses	0.2	0.2	0.3	-0.6	0.6	0.4	-0.5	-0.4	0.4
Short access day 1 total infusions	7.3	7.8	8.1	-2.8	2.8	2.9	-2.8	-2.8	2.7
Short access day 10 total infusions	3.6	4.0	4.4	-2.1	2.1	2.1	-2.0	-2.0	1.8
Short access total infusions	4.6	5.2	5.5	-2.3	2.3	2.3	-2.3	-2.2	2.1
Short access day 1 locomotion	3.2	3.5	4.1	-2.0	2.0	1.9	-1.7	-1.7	1.7
Short access day 10 total locomotion	4.3	4.8	5.9	-2.4	2.4	2.1	-2.1	-1.9	2.0
Short access total locomotion	3.5	3.6	4.3	-2.1	2.1	1.9	-1.8	-1.8	1.8
One hour access (0.3 mA shock)	4.6	5.3	5.8	-2.4	2.4	2.3	-2.3	-2.2	2.2
Compulsive drug intake	1.2	1.2	1.4	1.1	-1.1	-1.2	1.1	1.0	-1.0
One hour access (shock baseline)	6.5	7.5	8.1	-2.8	2.8	2.8	-2.8	-2.6	2.6
Social response proportion	4.5	4.9	5.3	2.2	-2.2	-2.2	2.2	2.3	-2.2
Social responses	0.1	0.1	0.2	-0.3	0.3	0.4	-0.3	-0.3	0.4
Social time	2.3	3.0	3.6	1.8	-1.8	-1.9	1.5	1.9	-1.5
Soleus weight	1.4	4.1	4.6	2.0	-2.0	-2.0	2.2	1.9	-2.1
Bone: stiffness	0.4	0.7	0.8	-0.9	0.9	0.9	-0.7	-0.8	0.6
Tibialis anterior weight	3.2	10.8	11.5	3.3	-3.3	-3.3	3.4	3.2	-3.4
Time to tail flick, vehicle, before self-admin	5.4	5.5	6.2	-2.3	2.3	2.3	-2.4	-2.5	2.2
Time to tail flick, vehicle, after self-admin	4.7	5.1	5.7	-2.3	2.3	2.2	-2.4	-2.1	2.3
Time to tail flick, test, before self-admin	0.7	0.7	1.0	-1.0	1.0	0.7	-0.9	-0.8	0.8
Time to tail flick, test, after self-admin	1.9	2.0	2.3	-1.5	1.5	1.4	-1.5	-1.2	1.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	0.3	-0.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.2	0.2	0.4	-0.3	-0.3	0.4
Tibia length	0.2	0.5	0.7	0.7	-0.7	-0.6	0.8	0.7	-0.8
Ambulatory time before self-admin	0.4	0.4	0.5	-0.7	0.7	0.7	-0.5	-0.7	0.4
Ambulatory time after self-admin	0.4	0.5	0.7	-0.9	0.9	0.6	-0.6	-0.5	0.5
Bone: tissue strength	0.0	0.0	0.0	-0.0	0.0	-0.0	0.0	0.0	-0.0
Total heroin consumption	0.7	0.8	0.9	0.9	-0.9	-0.8	1.0	0.9	-1.0
Bone: trabecular number	0.4	0.6	0.8	-0.7	0.7	0.9	-0.8	-0.9	0.8
Bone: trabecular spacing	0.3	0.4	0.6	-0.6	0.6	0.5	-0.7	-0.5	0.8
Bone: trabecular thickness	0.2	0.3	0.4	-0.5	0.5	0.6	-0.4	-0.6	0.4
Bone: trabecular tissue density	0.9	1.3	1.6	1.0	-1.0	-1.1	1.2	1.1	-1.2
Water consumed over 24 hours	0.1	0.1	0.2	-0.5	0.5	0.3	-0.2	-0.3	0.1
Number of responses in last shaping day	1.1	1.2	1.3	-1.1	1.1	1.2	-1.1	-1.1	0.9