Slc13a2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative polyA	NM_031746.1	0.04	0.04	1.4e-03	0.02	0.01	0.03	0.02	2.7e-03	2.3e-02	5.3e-04	1.8e-03
2	Liver	alternative polyA	XM_063269826.1	0.04	0.04	8.0e-04	0.02	0.01	0.03	0.02	2.1e-03	1.0e-02	2.4e-04	1.8e-03
3	Liver	isoform ratio	NM_031746.1	0.04	0.04	2.9e-04	0.03	0.03	0.03	0.03	2.7e-04	6.1e-04	5.3e-04	2.5e-04
4	Liver	gene expression	Slc13a2	0.56	0.14	0.0e+00	0.5	0.56	0.56	0.56	8.9e-63	4.8e-75	3.9e-74	3.3e-75
5	Liver	isoform ratio	XM_063269826.1	0.04	0.03	3.4e-04	0.03	0.03	0.03	0.03	2.1e-04	6.5e-04	1.2e-04	1.7e-04
6	Liver	mRNA stability	Slc13a2	0.04	0.04	7.2e-05	0.02	0.03	0.02	0.02	1.1e-03	2.2e-04	1.9e-03	1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.5	2.9	3.9	-1.8	1.8	-1.6	2.0	-1.3	1.6
Area under the delay curve	0.8	1.2	2.6	0.8	-0.8	1.1	-1.6	1.4	-0.4
BMI with tail	1.3	4.7	6.0	-2.4	2.4	-2.0	2.4	-1.9	1.6
BMI without tail	0.9	4.6	6.3	-2.3	2.3	-2.0	2.5	-1.9	1.7
Body weight	2.4	10.7	12.4	-3.5	3.5	-3.2	3.4	-2.9	3.1
Weight adjusted by age	0.0	0.1	0.2	-0.4	0.4	0.0	0.4	0.3	0.0
Bone surface	0.9	1.8	2.9	-1.5	1.5	-1.2	1.7	-1.0	1.2
Bone volume	0.9	1.9	2.6	-1.5	1.5	-1.3	1.6	-1.0	1.3
Breakpoint value in progressive ratio session	0.1	0.3	0.6	-0.2	0.2	-0.5	0.8	-0.7	0.3
Number of licking bursts	0.1	0.4	0.8	0.9	-0.9	0.4	-0.7	0.2	-0.4
Context. condit. distance diff. score	0.5	0.6	0.7	-0.8	0.8	-0.7	0.9	-0.4	0.8
Locomotion velocity, session 1	2.3	2.6	3.2	-1.6	1.6	-1.7	1.5	-1.8	1.5
Locomotion distance, session 1	0.3	0.4	1.0	-0.4	0.4	-0.7	0.5	-1.0	0.7
Locomotion velocity, session 2	0.1	0.1	0.2	-0.1	0.1	-0.3	0.2	-0.4	-0.3
Locomotion distance, session 2	1.0	1.5	2.6	-1.2	1.2	-1.4	1.3	-1.6	0.1
Locomotion velocity, session 3	4.6	5.2	6.4	2.3	-2.3	2.4	-2.0	2.2	-2.5
Locomotion distance, session 3	0.5	0.6	0.9	0.8	-0.8	1.0	-0.7	0.9	-0.4
Stereotopy head waving bouts, day 3	0.0	0.0	0.2	-0.0	0.0	-0.0	0.1	0.1	-0.4
Stereotopy head waving duration, day 3	0.8	1.0	2.0	1.0	-1.0	0.9	-0.8	1.0	-1.4
Locomotion velocity, session 7	0.1	0.1	0.3	-0.3	0.3	-0.0	0.5	0.2	0.5
Locomotion distance, session 7	0.3	0.4	0.7	-0.6	0.6	-0.4	0.8	-0.3	0.8
Stereotopy head waving bouts, day 7	0.3	0.4	0.6	-0.7	0.7	-0.6	0.8	-0.4	0.3
Stereotopy head waving duration, day 7	0.1	0.1	0.3	-0.3	0.3	-0.2	0.5	-0.0	0.1
Locomotion velocity, session 8	0.0	0.0	0.0	-0.2	0.2	-0.2	0.1	-0.1	-0.0
Locomotion distance, session 8	0.6	0.9	1.2	-1.0	1.0	-1.0	1.1	-0.9	0.5
Degree of sensitization distance	3.1	3.3	3.9	-2.0	2.0	-1.9	1.8	-1.7	1.5
Degree of sensitization stereotypy	0.4	0.4	0.7	-0.7	0.7	-0.7	0.8	-0.6	0.5
Conditioned locomotion	2.2	2.6	5.2	1.6	-1.6	1.4	-1.4	1.2	-2.3
Cocaine response after cond. corrected	1.2	1.8	2.6	-1.4	1.4	-1.6	1.4	-1.6	0.2
Cocaine response after cond. not corrected	1.5	2.2	3.0	-1.6	1.5	-1.7	1.5	-1.7	0.4
Cocaine response before conditioning	0.1	0.2	0.5	-0.3	0.3	-0.2	0.4	-0.2	0.7
Saline control response	0.0	0.0	0.1	0.2	-0.3	0.2	-0.0	0.2	-0.1
Bone: connectivity density	2.8	4.4	6.1	-2.2	2.1	-2.0	2.5	-1.7	2.1
Bone: cortical apparent density	0.2	0.4	0.6	0.6	-0.6	0.5	-0.8	0.4	-0.7
Bone: cortical area	1.4	2.3	2.8	1.3	-1.3	1.7	-1.5	1.6	-1.5
Bone: cortical porosity	0.3	0.4	1.5	-0.4	0.4	-0.2	0.6	0.0	1.2
Bone: cortical porosity	0.2	0.2	1.2	-0.2	0.2	0.0	0.4	0.2	1.1
Bone: cortical thickness	2.7	4.5	5.6	2.1	-2.0	2.4	-2.1	2.3	-1.8
Bone: cortical thickness	0.1	0.1	0.2	0.4	-0.4	0.4	-0.2	0.3	0.1
Bone: cortical tissue density	0.1	0.2	0.3	0.4	-0.4	0.3	-0.6	0.2	-0.5
Condit. Reinf. active minus inactive responses	0.9	1.1	1.5	1.1	-1.1	1.2	-0.9	1.1	-0.5
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	0.6	-0.6	0.9	-0.4	0.9	0.2
Condit. Reinf. active responses	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2	-0.0	-0.2
Condit. Reinf. inactive responses	0.6	0.7	1.7	-0.8	0.8	-1.1	0.6	-1.3	-0.2
Incentive salience index mean	0.5	0.6	0.9	0.8	-0.8	0.9	-0.6	0.9	-0.6
Condit. Reinf. lever presses	0.0	0.1	0.1	-0.3	0.3	0.0	0.3	0.2	-0.1
Condit. Reinf. active minus inactive responses	0.6	0.8	1.3	1.2	-1.1	0.9	-0.6	0.6	-1.0
Condit. Reinf. active-inactive response ratio	0.5	0.8	1.2	1.0	-1.0	0.8	-0.7	0.5	-1.1
Condit. Reinf. active responses	0.4	0.6	0.9	0.9	-0.9	0.8	-0.4	0.7	-0.7
Condit. Reinf. inactive responses	0.0	0.1	0.2	0.0	-0.1	0.3	0.2	0.5	0.1
Condit. Reinf. lever presses	2.5	3.6	4.4	2.1	-2.1	1.9	-1.8	1.6	-1.8
Condit. Reinf. lever reinforcers received	0.7	1.0	1.4	1.2	-1.2	1.0	-0.7	0.9	-1.0
Conditioned reinforcement - actives	0.1	0.5	1.6	-0.6	0.6	-0.5	0.7	-0.5	1.3
Conditioned reinforcement - inactives	0.1	0.3	0.5	-0.5	0.5	-0.5	0.4	-0.6	0.7
Conditioned locomotion	0.4	0.6	1.2	-0.9	0.8	-0.7	0.6	-0.5	1.1
Patch foraging indifference point 0 sec	0.4	1.0	1.6	1.1	-1.1	1.3	-0.8	1.2	-0.3
Patch foraging indifference point AUC	1.2	3.0	3.7	1.9	-1.9	1.6	-1.8	1.3	-1.9
Delay disc. indifference point, 0s delay	0.6	0.6	1.1	0.9	-0.8	0.9	-1.0	0.7	0.1
Delay disc. indifference point, 16s delay	0.3	0.5	1.9	0.1	-0.1	0.5	-1.4	0.8	-0.0
Delay disc. indifference point, 2s delay	1.9	2.2	3.0	1.5	-1.5	1.6	-1.7	1.6	-0.5
Delay disc. indifference point, 24s delay	0.4	0.7	1.2	-1.1	1.1	-0.8	0.8	-0.5	0.5
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.3	-0.3	0.3	-0.6	0.6	0.3
Delay disc. indifference point, 8s delay	0.5	0.8	1.4	0.5	-0.5	0.8	-1.2	1.1	-1.0
Indifference point function ln k	0.3	1.0	1.5	-1.1	1.1	-0.9	1.0	-0.7	1.2
Indifference point function log k	0.3	1.0	1.5	-1.1	1.1	-0.9	1.0	-0.7	1.2
Patch foraging total patch changes 0 sec	0.3	0.9	1.4	1.0	-1.0	1.2	-0.7	1.1	-0.3
Patch foraging total patch changes 12 sec	0.2	0.2	0.4	0.6	-0.6	0.5	-0.5	0.3	-0.2
Patch foraging total patch changes 18 sec	1.0	2.4	3.2	1.8	-1.8	1.6	-1.5	1.3	-1.3
Patch foraging total patch changes 24 sec	1.0	3.3	4.5	2.1	-2.1	1.9	-1.7	1.5	-1.3
Patch foraging total patch changes 6 sec	2.8	4.8	5.6	2.4	-2.4	2.3	-2.2	2.1	-1.7
Patch foraging time to switch 0 sec	0.6	2.4	3.1	-1.8	1.8	-1.7	1.5	-1.5	0.9
Patch foraging water rate 0 sec	0.8	2.9	3.9	2.0	-2.0	1.8	-1.6	1.5	-1.0
Patch foraging water rate 12 sec	0.2	0.7	2.5	-0.6	0.6	-0.5	0.7	-0.4	1.6
Patch foraging water rate 18 sec	0.6	1.2	2.2	-1.1	1.1	-1.1	1.0	-0.8	1.5
Patch foraging water rate 24 sec	0.1	0.2	0.2	0.5	-0.5	0.5	-0.5	0.4	-0.1
Patch foraging water rate 6 sec	0.8	1.1	1.4	1.2	-1.2	1.2	-1.1	1.1	-0.5
Seeking ratio, delayed vs. immediate footshock	1.6	2.3	2.5	1.6	-1.6	1.6	-1.5	1.5	-1.3
Distance traveled before self-admin	1.8	4.0	6.2	1.9	-1.9	2.3	-2.1	2.5	-1.0
Distance traveled after self-admin	0.1	0.1	0.3	0.0	-0.0	0.3	-0.3	0.5	0.5
Extensor digitorum longus weight	0.6	2.3	3.3	-1.8	1.8	-1.4	1.7	-1.1	1.0
Bone: elastic displacement	2.6	3.3	3.7	1.9	-1.9	1.9	-1.9	1.8	-1.5
Bone: elastic work	8.7	11.4	14.5	3.5	-3.5	3.8	-3.3	3.5	-2.3
Bone: endosteal estimation	0.0	0.0	0.0	0.1	-0.1	0.0	-0.1	-0.1	0.1
Bone: endosteal perimeter	0.0	0.1	0.2	-0.2	0.2	-0.3	0.1	-0.4	-0.4
Epididymis fat weight	5.6	28.5	33.7	-5.8	5.8	-5.6	5.4	-4.9	4.4
Delta time in closed arm before/after self-admin	3.0	2.8	5.0	1.2	-1.3	1.5	-1.7	1.9	-2.2
Delta time in open arm before/after self-admin	5.1	6.0	9.4	-1.8	1.9	-2.2	2.5	-2.9	3.1
Diff in mean of infusions in LGA sessions	0.3	0.6	1.1	-0.6	0.6	-0.8	0.8	-1.1	0.8
Delay discount exponential model param	0.6	0.9	1.8	-0.6	0.6	-1.0	1.3	-1.3	0.3
Extinction: sum of active levers before priming	0.7	1.0	2.8	-0.6	0.6	-0.7	1.0	-0.9	1.7
Active lever presses in extinction session 6	0.3	0.3	1.1	-0.2	0.2	0.1	0.6	0.3	1.1
Bone: final force	0.6	1.0	1.9	0.9	-0.9	1.4	-0.7	1.3	-0.4
Bone: final moment	0.7	1.1	2.1	0.9	-0.9	1.4	-0.8	1.4	-0.2
Food consumed during 24 hour testing period	0.3	0.5	1.6	0.5	-0.5	0.9	-0.5	1.3	0.4
Glucose	1.2	1.8	2.4	1.3	-1.3	1.3	-1.5	1.1	-1.6
Heart weight	0.8	1.3	2.4	-1.2	1.2	-1.0	1.5	-0.9	0.6
Delay discount hyperbolic model param	1.1	1.4	2.4	-0.9	0.9	-1.3	1.5	-1.5	0.3
Intermittent access intake day 1-15 change	0.0	0.2	1.2	-0.1	0.1	-0.1	0.2	-0.0	1.1
Intermittent access intake escalation	0.1	0.3	1.3	-0.2	0.2	-0.2	0.3	-0.2	1.1
Intermittent access intake escalation 2	0.1	0.1	0.2	0.3	-0.3	0.3	-0.4	0.4	0.1
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.3	0.4	-0.4	0.6	-0.4	0.5	-0.6
Intermitt. access day 15 inactive lever presses	0.1	0.6	1.3	1.1	-1.1	0.5	-0.8	0.1	-0.4
Intermitt. access escalation Index	0.6	1.8	2.4	-1.5	1.5	-1.5	1.1	-1.0	1.2
Intermittent access day 1 total infusions	0.1	0.3	0.7	-0.5	0.5	-0.6	0.3	-0.8	0.4
Intermittent access day 15 total infusions	0.6	1.4	3.0	-0.9	0.9	-1.1	1.0	-1.3	1.7
Intermittent access terminal intake (last 3 days)	1.1	1.8	3.7	-1.2	1.2	-1.3	1.1	-1.3	1.9
Intermittent access total infusions	0.4	0.5	1.0	-0.5	0.5	-0.6	0.5	-0.8	1.0
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.2	0.2	-0.1	0.1	-0.2	0.1
Intermittent access day 15 total locomotion	0.1	0.5	0.8	-0.7	0.7	-0.6	0.7	-0.6	0.9
Intermittent access total locomotion	0.5	0.6	1.0	-0.7	0.7	-0.6	0.8	-0.8	1.0
Intermittent access standard deviation	0.0	0.1	0.2	0.0	-0.0	-0.3	-0.0	-0.5	0.4
Left kidney weight	0.0	0.1	0.2	-0.5	0.5	-0.3	0.5	-0.1	-0.0
Right kidney weight	0.1	0.6	0.9	-0.9	0.9	-0.7	0.9	-0.6	0.5
Cocaine induced anxiety	0.1	0.2	0.3	0.6	-0.6	0.4	-0.4	0.1	-0.3
Post-drug Anxiety	0.1	0.1	0.2	-0.2	0.2	-0.4	0.5	-0.4	0.4
Baseline Anxiety	0.1	0.2	0.4	-0.4	0.4	-0.5	0.7	-0.3	0.4
Tail length	0.4	2.2	4.3	-1.4	1.4	-1.4	1.3	-1.2	2.1
Length with tail	0.8	3.4	5.6	-1.9	1.9	-1.7	1.6	-1.5	2.4
Length without tail	0.4	1.9	2.4	-1.6	1.6	-1.4	1.1	-1.1	1.5
Times rat made contact with spout	0.3	0.3	1.1	0.2	-0.2	0.7	-0.2	1.0	0.1
Lifetime Intake	0.6	0.8	1.3	-0.7	0.7	-0.9	0.7	-1.1	1.1
Liver weight, left	5.1	8.9	10.0	-3.1	3.1	-3.2	2.9	-2.9	2.5
Liver weight, right	3.6	6.3	7.3	-2.7	2.7	-2.6	2.7	-2.4	1.9
Locomotor activity	0.0	0.1	0.4	0.2	-0.2	0.0	-0.0	-0.0	0.6
Locomotor testing distance	0.0	0.0	0.1	0.2	-0.2	0.0	-0.2	-0.0	0.4
Locomotor testing rearing	0.0	0.1	0.2	0.4	-0.4	0.1	-0.2	-0.0	0.0
Locomotion in novel chamber	1.9	2.5	3.9	1.0	-1.1	1.6	-1.8	2.0	-1.8
Locomotion in novel chamber post-restriction	0.0	0.1	0.2	-0.3	0.3	0.1	0.1	0.4	0.0
Fecal boli incidents, locomotor time 1	0.7	1.8	2.3	-1.3	1.3	-1.4	1.5	-1.5	0.9
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	0.2	-0.2	0.3	-0.5	0.5	0.0
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.8	0.2	-0.2	0.4	0.1	0.5	0.9
Bouts of movement, locomotor time 1	0.3	0.4	0.5	0.6	-0.6	0.7	-0.7	0.7	-0.7
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.4	-0.4	0.3	-0.3	0.4	-0.3
Rest time, locomotor task time 1	0.0	0.1	0.4	0.2	-0.2	0.0	0.6	-0.1	-0.0
Distance moved, locomotor task time 1	0.1	0.2	0.5	0.4	-0.4	0.5	-0.7	0.6	0.1
Vertical activity count, locomotor time 1	0.0	0.1	0.2	0.3	-0.3	0.3	-0.5	0.3	0.2
Time >=10cm from walls, locomotor time 2	0.5	1.3	6.4	-0.2	0.2	-0.2	1.0	-0.3	2.5
Bouts of movement, locomotor time 2	0.1	0.4	0.6	0.7	-0.8	0.5	-0.7	0.6	-0.1
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.4	-0.4	0.3	-0.3	0.4	-0.0
Rest time, locomotor task time 2	0.2	0.4	1.6	0.5	-0.5	0.2	0.1	0.1	-1.2
Distance moved, locomotor task time 2	0.1	0.1	0.5	-0.0	-0.0	0.1	-0.7	0.2	0.0
Vertical activity count, locomotor time 2	0.1	0.1	0.7	0.1	-0.1	0.2	-0.8	0.2	0.3
Light reinforcement 1	0.0	0.0	0.0	0.0	-0.0	0.0	-0.1	0.1	0.2
Light reinforcement 2	0.2	0.5	0.6	0.6	-0.6	0.7	-0.8	0.7	-0.7
Bone: marrow area	0.0	0.0	0.0	0.1	-0.1	0.0	-0.1	-0.1	0.0
Bone: maximum diameter	0.4	0.8	1.1	0.8	-0.7	1.0	-0.8	1.0	-1.0
Bone: maximum force	0.6	1.2	2.0	1.0	-1.0	1.4	-1.0	1.3	-0.5
Bone: maximum moment	0.7	1.3	2.3	1.1	-1.1	1.5	-1.1	1.5	-0.4
Mean time between licks in bursts	0.2	1.1	1.5	-1.2	1.2	-1.1	0.9	-1.1	0.6
Mean num. licks in bursts	0.2	0.4	0.7	-0.9	0.9	-0.1	0.6	0.3	0.6
Cd content in liver	0.6	0.7	1.4	0.9	-0.9	0.3	-0.9	-0.1	-1.2
Co content in liver	0.7	0.8	1.8	1.0	-1.0	0.9	-0.6	0.5	-1.3
Cu content in liver	2.0	2.4	3.6	1.6	-1.6	1.5	-1.4	1.3	-1.9
Fe content in liver	1.9	2.4	3.8	-1.2	1.3	-1.7	1.6	-2.0	1.4
K content in liver	0.2	0.1	0.4	-0.3	0.4	-0.2	0.3	-0.3	0.6
Mg content in liver	0.9	1.0	1.6	1.3	-1.2	1.1	-0.8	0.7	-0.8
Mn content in liver	0.3	0.3	0.6	0.5	-0.5	0.5	-0.5	0.3	-0.8
Na content in liver	0.4	0.5	0.9	-0.6	0.6	-0.8	0.1	-1.0	0.8
Rb content in liver	0.1	0.1	0.6	-0.0	0.0	-0.2	0.3	-0.4	0.7
Se content in liver	1.0	1.1	2.3	1.5	-1.5	1.0	-0.8	0.2	-0.8
Sr content in liver	0.5	0.4	0.6	-0.7	0.7	-0.6	0.7	-0.4	0.8
Zn content in liver	0.3	0.4	0.8	-0.2	0.3	-0.5	0.6	-0.9	0.8
Bone: minimum diameter	0.2	0.4	1.8	0.2	-0.2	0.3	-0.4	0.3	-1.3
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.4	-0.4	0.4	-0.6	0.5	-0.3
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.3	0.3	-0.4	0.4	-0.4	0.3
Total zone transitions, hab. session 1	0.0	0.1	0.2	-0.1	0.1	-0.2	-0.2	-0.3	-0.4
Total locomotion distance, hab. session 1	0.0	0.0	0.1	0.1	-0.1	-0.0	-0.3	-0.0	-0.2
Locomotion velocity, hab. session 1	0.2	0.2	0.4	0.5	-0.5	0.4	-0.7	0.3	-0.5
Time in familiar zone, hab. session 2	0.2	0.2	0.3	0.5	-0.5	0.4	-0.4	0.3	-0.5
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.2	-0.2	0.3	-0.4	0.3	0.0
Total zone transitions, hab. session 2	0.4	0.5	0.8	-0.7	0.7	-0.8	0.6	-0.9	-0.4
Total locomotion distance, hab. session 2	0.2	0.3	1.1	0.4	-0.3	0.1	-0.3	-0.2	-1.1
Locomotion velocity, hab. session 2	0.2	0.3	1.3	0.4	-0.4	0.1	-0.3	-0.2	-1.1
Novel to familiar place preference ratio	0.7	1.0	1.3	-1.0	1.0	-0.9	1.0	-0.8	1.2
Novelty place preference	1.0	1.3	1.6	-1.2	1.2	-1.1	1.1	-0.9	1.3
Time in novel zone, NPP test	1.1	1.3	1.7	-1.2	1.2	-1.1	1.1	-1.0	1.3
Total zone transitions, NPP test	0.0	0.1	0.3	-0.1	0.1	-0.3	0.1	-0.5	-0.2
Total locomotion distance, NPP test	0.8	1.2	2.3	1.2	-1.2	0.8	-1.1	0.4	-1.5
Locomotion velocity, NPP test	1.0	1.4	2.6	1.3	-1.3	0.9	-1.2	0.4	-1.6
Intraocular pressure	0.7	1.2	1.7	1.2	-1.2	1.0	-1.3	0.9	-0.8
Delta distance traveled before/after self-admin	2.7	3.0	3.9	-1.6	1.6	-1.6	1.8	-1.7	2.0
Delta ambulatory time before/after self-admin	1.5	2.6	4.2	-1.3	1.3	-1.7	1.6	-2.0	1.7
Parametrial fat weight	5.6	13.1	16.0	-4.0	4.0	-3.9	3.8	-3.4	2.3
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.2	0.2	-0.4	0.2	-0.5	0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	0.1	-0.1	0.1	-0.1	-0.2
Pavlov. Cond. change in total contacts	0.5	0.6	1.4	0.7	-0.7	0.6	-0.6	0.5	-1.2
Pavlov. Cond. index score	0.1	0.1	0.4	0.2	-0.2	0.3	-0.2	0.3	-0.6
Pavlov. Cond. latency score	0.0	0.0	0.1	0.0	-0.0	0.2	-0.0	0.2	-0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.1	-0.1	0.2	-0.1	0.3	-0.3
Pavlov. Cond. magazine entry number	0.2	0.2	0.7	-0.4	0.4	-0.4	0.4	-0.3	0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	0.6	-0.6	0.4	-0.5	0.1	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.7	0.3	-0.3	0.5	-0.3	0.4	-0.8
Pavlov. Cond. response bias	0.1	0.1	0.3	0.1	-0.1	0.2	-0.1	0.2	-0.5
Pavlov. Cond. lever latency	2.1	3.0	3.7	-1.9	1.9	-1.6	1.9	-1.3	1.7
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.5	-0.5	0.5	-0.6	0.3	-0.4
Pavlov. Cond. change in total contacts	0.8	2.0	2.7	1.6	-1.6	1.5	-1.5	1.1	-1.1
Pavlov. Cond. index score	1.8	2.8	3.4	1.8	-1.8	1.6	-1.8	1.2	-1.7
Pavlov. Cond. latency score	2.0	3.3	4.1	2.0	-2.0	1.8	-2.0	1.4	-1.7
Pavlov. Cond. lever contacts	1.3	2.0	2.5	1.6	-1.6	1.3	-1.4	1.0	-1.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.3	0.2	-0.1	0.2	0.2	0.2
Pavlov. Cond. intertrial magazine entries	0.3	0.6	0.8	-0.9	0.9	-0.9	0.9	-0.7	0.5
Pavlov. Cond. lever-magazine prob. diff.	1.4	2.2	2.7	1.6	-1.6	1.4	-1.6	1.0	-1.5
Pavlov. Cond. response bias	1.0	1.4	1.7	1.3	-1.3	1.0	-1.3	0.7	-1.3
Time in closed arm before self-admin	1.3	2.3	2.9	-1.4	1.4	-1.6	1.3	-1.7	1.6
Time in closed arm after self-admin	0.5	0.5	1.6	-0.2	0.2	0.0	-1.0	0.7	-1.3
Time in open arm before self-admin	2.1	2.5	3.5	1.5	-1.5	1.7	-1.4	1.9	-1.5
Time in open arm after self-admin	0.7	0.8	1.9	-0.4	0.4	-0.6	1.1	-1.0	1.4
Bone: periosteal estimation	0.4	0.8	1.0	0.9	-0.9	1.0	-0.9	0.9	-0.9
Bone: periosteal perimeter	0.2	0.5	1.0	0.5	-0.4	0.7	-0.7	0.7	-1.0
Bone: post-yield work	0.2	0.4	0.7	-0.9	0.9	-0.6	0.6	-0.4	0.1
Progressive ratio test 1 active lever presses	0.2	0.4	0.6	0.8	-0.8	0.6	-0.8	0.3	-0.1
Progressive ratio test 1 breakpoint	0.3	0.5	0.8	0.9	-0.9	0.7	-0.8	0.4	-0.1
Progressive ratio test 1 inactive lever presses	0.6	1.5	2.4	1.3	-1.3	1.3	-1.6	1.0	-0.5
Progressive ratio test 2 active lever presses	0.3	0.4	0.6	0.8	-0.8	0.8	-0.7	0.6	-0.2
Progressive ratio test 2 breakpoint	0.3	0.4	0.6	0.8	-0.8	0.8	-0.6	0.5	-0.2
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	0.3	-0.3	0.5	-0.4	0.4	0.2
Incentive Sensitization - Responses	0.0	0.0	0.1	0.1	-0.1	0.3	0.1	0.1	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.1	-0.1	0.2	0.1	0.1	0.2
Sum of active levers in priming session hrs 5-6	1.1	1.1	2.4	-0.7	0.7	-0.8	1.2	-1.0	1.5
Progressive ratio	0.1	0.3	0.5	0.5	-0.5	0.7	0.3	0.6	0.2
Food seeking constrained by brief footshock	0.2	0.2	0.4	-0.2	0.2	-0.5	0.4	-0.6	0.6
Seeking ratio, punishment vs. effort	0.1	0.2	0.4	-0.4	0.4	-0.6	-0.4	-0.5	-0.1
Retroperitoneal fat weight	0.8	3.4	4.6	-2.1	2.1	-2.1	1.5	-1.8	1.3
Reaction time number correct	0.3	1.2	1.4	-1.1	1.1	-1.1	1.2	-1.0	1.2
Reaction time mean minus median	0.1	0.5	1.1	-0.6	0.6	-0.9	0.5	-1.0	0.1
Reaction time mean minus median AUC	0.5	3.0	4.6	-1.8	1.8	-2.1	1.5	-2.2	0.9
Reaction time num false alarms	4.5	7.6	9.0	2.8	-2.8	3.0	-2.7	3.0	-2.1
Reaction time num false alarms AUC	3.5	8.0	9.9	2.9	-2.9	3.1	-2.8	3.1	-2.1
Reaction time trials correct on left	0.3	1.2	1.4	-1.1	1.1	-1.1	1.2	-1.0	1.2
Reaction time trials on left	0.4	1.3	1.4	-1.1	1.1	-1.1	1.2	-1.0	1.2
Reaction time mean	0.6	1.3	2.4	-1.1	1.1	-1.5	1.0	-1.6	-0.0
Reaction time mean AUC	0.4	1.1	2.0	-1.0	1.0	-1.3	0.8	-1.4	-0.1
Median of all reaction times	0.6	1.0	2.0	-0.9	0.8	-1.3	0.8	-1.4	-0.3
Reaction time omissions	1.3	2.1	2.6	-1.6	1.6	-1.4	1.3	-1.1	1.5
Reaction time false alarm rate	6.0	8.3	9.8	2.9	-2.9	3.1	-2.8	3.1	-2.3
Reaction time premature initiation rate	0.2	0.3	0.5	-0.7	0.7	-0.5	0.5	-0.3	0.5
Reaction time premature initiations	0.2	0.7	0.9	-1.0	1.0	-0.8	0.8	-0.6	0.8
Std. dev. reaction times	0.4	1.5	2.1	-1.2	1.2	-1.4	1.1	-1.5	0.8
Reaction time trials completed	0.4	1.3	1.4	-1.1	1.1	-1.1	1.2	-1.0	1.2
Reaction time trials AUC	0.3	1.0	1.2	-1.0	1.0	-0.9	1.1	-0.9	1.1
Run reversals in cocaine runway, females	0.4	0.5	0.8	-0.9	0.9	-0.8	0.3	-0.6	0.6
Run reversals in cocaine runway, males	0.2	0.2	0.5	-0.7	0.7	-0.5	0.3	-0.2	-0.0
Latency to leave start box in cocaine runway	1.0	1.4	2.9	1.2	-1.2	1.5	-0.4	1.7	-0.3
Latency to leave start box in cocaine runway, F	0.3	0.3	0.7	0.6	-0.6	0.7	-0.1	0.8	0.1
Latency to leave start box in cocaine runway, M	0.8	0.8	2.2	0.7	-0.7	1.1	-0.2	1.5	-0.2
Std. dev. time between licks in bursts	0.0	0.1	0.2	-0.5	0.5	-0.2	0.0	0.0	-0.1
Total sessions with >9 infusions	0.6	0.7	1.0	-0.9	0.9	-0.9	0.5	-1.0	0.9
Short access day 1 total inactive lever presses	2.4	4.8	5.4	-2.3	2.3	-2.1	2.1	-2.1	2.3
Short access day 10 total inactive lever presses	0.0	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.0	-0.0
Short access day 1 total infusions	0.5	1.0	2.0	-0.7	0.7	-1.0	0.7	-1.4	1.2
Short access day 10 total infusions	0.4	0.7	1.2	-0.8	0.8	-1.0	0.5	-1.1	0.7
Short access total infusions	0.3	0.4	1.1	-0.5	0.5	-0.7	0.3	-1.0	0.6
Short access day 1 locomotion	0.0	0.1	0.1	0.2	-0.2	0.0	-0.2	-0.2	0.4
Short access day 10 total locomotion	0.2	0.8	1.5	1.2	-1.2	0.9	-0.8	0.4	-0.1
Short access total locomotion	0.3	0.4	0.6	0.8	-0.7	0.7	-0.8	0.4	-0.3
One hour access (0.3 mA shock)	0.1	0.1	0.1	0.3	-0.3	0.2	-0.3	-0.1	0.2
Compulsive drug intake	0.7	1.0	1.2	-1.0	1.0	-1.1	1.1	-1.1	0.7
One hour access (shock baseline)	0.0	0.1	0.2	0.4	-0.4	0.3	-0.4	0.2	0.2
Social response proportion	1.8	2.3	2.7	-1.6	1.6	-1.5	1.5	-1.3	1.4
Social responses	1.7	2.3	2.7	-1.5	1.5	-1.5	1.6	-1.5	1.6
Social time	1.2	1.9	2.2	-1.5	1.5	-1.5	1.3	-1.4	1.3
Soleus weight	1.9	5.6	7.0	-2.6	2.6	-2.4	2.6	-2.1	1.7
Bone: stiffness	1.6	2.8	3.9	-1.7	1.7	-1.5	1.8	-1.4	2.0
Tibialis anterior weight	2.2	7.5	9.5	-3.0	3.0	-2.7	3.1	-2.3	2.3
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.7	0.7	-0.4	0.2	-0.2	0.4
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.5	0.7	-0.7	0.5	-0.7	0.2	-0.3
Time to tail flick, test, before self-admin	0.2	0.2	0.7	-0.4	0.4	-0.4	0.1	-0.1	-0.8
Time to tail flick, test, after self-admin	1.1	1.1	3.5	0.8	-0.8	0.8	-0.6	1.1	-1.9
Delta time to tail flick, vehicle, before/after SA	0.6	0.7	1.2	1.1	-1.1	0.7	-0.6	0.3	-0.9
Delta time to tail flick, test, before/after SA	0.6	0.7	1.0	1.0	-1.0	0.8	-0.7	0.6	-0.7
Tibia length	0.0	0.0	0.1	-0.0	0.0	0.2	-0.3	0.3	-0.1
Ambulatory time before self-admin	0.5	1.5	3.2	0.9	-0.9	1.4	-1.5	1.8	-0.3
Ambulatory time after self-admin	0.1	0.1	0.6	-0.3	0.3	-0.0	0.0	0.1	0.8
Bone: tissue strength	1.8	1.8	3.0	1.2	-1.2	1.6	-1.3	1.7	-0.9
Total heroin consumption	2.0	2.4	4.4	-1.4	1.4	-1.4	2.1	-1.4	1.5
Bone: trabecular number	2.1	4.0	5.1	-2.1	2.0	-2.0	2.3	-1.8	1.9
Bone: trabecular spacing	0.3	0.4	0.6	0.5	-0.5	0.7	-0.6	0.8	-0.5
Bone: trabecular thickness	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1	0.2	0.2
Bone: trabecular tissue density	0.8	1.4	1.9	1.3	-1.3	1.0	-1.4	0.8	-1.1
Water consumed over 24 hours	0.1	0.1	0.1	0.3	-0.3	0.3	-0.2	0.4	0.3
Number of responses in last shaping day	1.0	1.3	2.2	1.1	-1.1	1.1	-1.2	0.9	-1.5