Slc12a6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	alternative TSS	XM_006234710.5	0.03	0.02	2.2e-03	0.03	0.03	0.02	0.02	1.8e-03	2.2e-03	4.6e-03	3.4e-03
2	pVTA	gene expression	Slc12a6	0.04	0.04	1.6e-03	0.02	0.03	0.03	0.03	9.5e-03	9.2e-04	2.0e-03	1.9e-03
3	Brain	isoform ratio	XM_006234710.5	0.03	0.03	4.6e-04	0.04	0.04	0.04	0.03	3.0e-04	3.3e-04	2.4e-04	3.8e-04
4	Adipose	mRNA stability	Slc12a6	0.03	0.03	2.7e-03	0.02	0.02	0	0.01	6.3e-03	4.7e-03	1.3e-01	7.1e-03
5	Adipose	gene expression	Slc12a6	0.29	0.19	0.0e+00	0.2	0.21	0.21	0.21	3.2e-22	1.2e-22	1.4e-22	2.0e-22
6	OFC	gene expression	Slc12a6	0.17	0.18	8.6e-03	0.04	-0.01	-0.01	0.02	4.8e-02	5.0e-01	5.2e-01	1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.3	0.5	0.8	0.7	-0.6	0.5	0.6	-0.7	0.9
Area under the delay curve	0.8	0.9	1.2	-1.0	1.0	-1.0	-1.0	1.1	-0.3
BMI with tail	0.7	2.4	3.3	1.8	-1.7	1.6	1.6	-1.5	0.9
BMI without tail	0.7	2.0	2.8	1.7	-1.6	1.4	1.4	-1.3	1.1
Body weight	0.1	0.2	0.4	0.6	-0.4	0.3	0.4	-0.4	0.6
Weight adjusted by age	0.3	0.5	0.6	-0.8	0.6	-0.6	-0.7	0.8	-0.7
Bone surface	0.5	0.8	1.1	0.9	-0.8	0.8	0.9	-0.9	1.1
Bone volume	0.9	1.5	1.9	1.3	-1.2	1.1	1.2	-1.3	1.4
Breakpoint value in progressive ratio session	0.2	0.2	0.3	-0.4	0.5	-0.5	-0.5	0.5	-0.3
Number of licking bursts	0.2	0.4	0.5	0.5	-0.6	0.7	0.7	-0.7	0.6
Context. condit. distance diff. score	2.3	2.8	3.1	1.6	-1.6	1.6	1.7	-1.7	1.8
Locomotion velocity, session 1	0.9	0.9	1.0	-0.9	1.0	-1.0	-1.0	1.0	-0.9
Locomotion distance, session 1	0.1	0.1	0.2	-0.3	0.2	-0.3	-0.3	0.4	-0.3
Locomotion velocity, session 2	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.2	0.3	-0.2
Locomotion distance, session 2	0.1	0.1	0.2	-0.3	0.3	-0.4	-0.4	0.5	-0.3
Locomotion velocity, session 3	0.1	0.1	0.2	-0.2	0.2	-0.3	-0.4	0.5	-0.4
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	0.1	-0.2	-0.1	0.1	-0.1
Stereotopy head waving bouts, day 3	2.0	2.3	2.6	1.5	-1.5	1.5	1.5	-1.4	1.6
Stereotopy head waving duration, day 3	2.6	3.1	3.5	1.7	-1.8	1.8	1.8	-1.7	1.9
Locomotion velocity, session 7	4.7	5.1	5.3	2.3	-2.3	2.2	2.3	-2.2	2.3
Locomotion distance, session 7	2.2	2.8	3.8	1.6	-1.6	1.5	1.7	-1.7	1.9
Stereotopy head waving bouts, day 7	1.4	1.6	1.8	-1.3	1.3	-1.3	-1.3	1.3	-0.9
Stereotopy head waving duration, day 7	1.0	1.2	1.3	-1.1	1.2	-1.1	-1.1	1.1	-0.9
Locomotion velocity, session 8	0.7	0.9	1.0	1.0	-1.0	1.0	1.0	-1.0	0.8
Locomotion distance, session 8	1.2	1.7	2.0	1.3	-1.3	1.3	1.3	-1.3	1.4
Degree of sensitization distance	2.1	2.2	2.8	1.4	-1.4	1.4	1.5	-1.6	1.7
Degree of sensitization stereotypy	3.8	4.1	4.6	-2.0	2.2	-2.1	-2.1	2.0	-1.7
Conditioned locomotion	1.9	2.2	2.9	-1.5	1.4	-1.4	-1.4	1.5	-1.7
Cocaine response after cond. corrected	0.5	0.6	0.8	-0.8	0.7	-0.7	-0.8	0.9	-0.9
Cocaine response after cond. not corrected	0.3	0.4	0.5	-0.6	0.6	-0.6	-0.7	0.7	-0.6
Cocaine response before conditioning	0.1	0.1	0.2	0.3	-0.2	0.2	0.2	-0.3	0.5
Saline control response	0.0	0.0	0.0	0.0	-0.0	0.0	0.0	-0.0	-0.0
Bone: connectivity density	0.3	0.5	0.8	0.7	-0.7	0.6	0.7	-0.7	0.9
Bone: cortical apparent density	2.2	3.0	3.6	-1.8	1.9	-1.8	-1.7	1.6	-1.7
Bone: cortical area	0.7	1.1	1.4	1.0	-1.1	1.2	1.1	-1.0	0.9
Bone: cortical porosity	0.2	0.2	0.6	-0.1	0.1	-0.1	-0.3	0.5	-0.8
Bone: cortical porosity	0.1	0.1	0.5	-0.2	0.1	-0.1	-0.3	0.5	-0.7
Bone: cortical thickness	0.0	0.0	0.0	-0.1	0.1	0.0	-0.0	-0.0	0.0
Bone: cortical thickness	1.5	1.7	2.0	-1.4	1.3	-1.1	-1.3	1.3	-1.4
Bone: cortical tissue density	2.7	3.7	4.4	-1.9	2.1	-1.9	-1.9	1.8	-1.9
Condit. Reinf. active minus inactive responses	0.5	0.6	0.8	0.7	-0.6	0.8	0.7	-0.9	0.9
Condit. Reinf. active-inactive response ratio	3.3	3.6	3.9	1.9	-1.8	2.0	1.9	-2.0	1.8
Condit. Reinf. active responses	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.0	-0.1	0.3
Condit. Reinf. inactive responses	2.3	2.8	3.3	-1.7	1.8	-1.8	-1.7	1.6	-1.3
Incentive salience index mean	1.1	1.3	1.6	1.1	-1.0	1.1	1.1	-1.3	1.3
Condit. Reinf. lever presses	0.5	0.6	1.2	0.7	-0.6	0.7	0.8	-0.9	1.1
Condit. Reinf. active minus inactive responses	0.5	0.7	0.8	0.8	-0.8	0.8	0.9	-0.9	0.8
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.3	1.1	-1.1	1.1	1.1	-1.1	0.9
Condit. Reinf. active responses	0.6	0.9	1.1	0.9	-0.8	0.8	1.0	-1.1	1.0
Condit. Reinf. inactive responses	0.8	1.0	1.6	0.9	-0.8	0.9	1.0	-1.1	1.3
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.0	-0.1	0.1
Condit. Reinf. lever reinforcers received	0.2	0.3	0.4	0.4	-0.4	0.4	0.5	-0.6	0.6
Conditioned reinforcement - actives	1.0	1.7	2.4	-1.6	1.3	-1.3	-1.3	1.2	-1.0
Conditioned reinforcement - inactives	1.1	1.6	1.7	-1.3	1.3	-1.3	-1.3	1.2	-1.2
Conditioned locomotion	0.3	0.3	0.6	-0.8	0.6	-0.7	-0.6	0.6	-0.2
Patch foraging indifference point 0 sec	2.1	3.8	4.8	1.9	-1.9	2.2	2.0	-2.0	1.7
Patch foraging indifference point AUC	1.3	1.8	2.6	-1.2	1.4	-1.6	-1.3	1.2	-1.3
Delay disc. indifference point, 0s delay	2.1	2.3	2.7	-1.5	1.5	-1.5	-1.6	1.6	-1.3
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.1	0.2	-0.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.3	0.2	-0.3	-0.3	0.3	0.4
Delay disc. indifference point, 24s delay	0.5	0.6	0.7	-0.7	0.8	-0.8	-0.8	0.8	-0.6
Delay disc. indifference point, 4s delay	1.7	1.8	2.0	-1.3	1.4	-1.4	-1.4	1.4	-1.2
Delay disc. indifference point, 8s delay	0.3	0.3	0.4	-0.6	0.6	-0.6	-0.6	0.7	0.2
Indifference point function ln k	0.8	1.4	1.7	1.1	-1.3	1.3	1.2	-1.1	1.1
Indifference point function log k	0.8	1.4	1.7	1.1	-1.3	1.3	1.2	-1.1	1.1
Patch foraging total patch changes 0 sec	1.7	3.2	4.1	1.7	-1.7	2.0	1.8	-1.9	1.5
Patch foraging total patch changes 12 sec	0.9	1.1	1.3	1.1	-1.0	1.0	1.1	-1.1	0.9
Patch foraging total patch changes 18 sec	0.6	0.9	1.2	-0.8	1.0	-1.0	-0.9	0.8	-1.1
Patch foraging total patch changes 24 sec	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1	0.0	-0.2
Patch foraging total patch changes 6 sec	1.2	1.8	2.3	1.4	-1.3	1.5	1.4	-1.5	0.9
Patch foraging time to switch 0 sec	0.1	0.2	0.2	0.3	-0.4	0.4	0.4	-0.4	0.5
Patch foraging water rate 0 sec	1.1	2.3	2.7	1.6	-1.5	1.5	1.5	-1.5	1.4
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.1	-0.2	0.3	0.2	-0.2	-0.3
Patch foraging water rate 18 sec	0.4	0.7	1.2	0.8	-0.9	1.1	0.8	-0.8	0.5
Patch foraging water rate 24 sec	0.7	1.0	1.4	0.9	-1.0	1.2	1.0	-1.1	0.8
Patch foraging water rate 6 sec	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.2	0.2	-0.1
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.0	0.8	-0.8	0.8	0.9	-1.0	0.7
Distance traveled before self-admin	1.5	2.0	2.7	-1.5	1.6	-1.5	-1.5	1.4	-0.8
Distance traveled after self-admin	0.0	0.1	0.2	0.0	-0.1	0.2	0.1	-0.2	0.5
Extensor digitorum longus weight	0.2	0.9	1.3	-0.9	0.9	-0.9	-0.9	0.9	-1.1
Bone: elastic displacement	0.0	0.0	0.1	-0.3	0.2	-0.2	-0.1	0.0	0.0
Bone: elastic work	0.0	0.0	0.1	0.1	-0.2	0.2	0.2	-0.3	0.1
Bone: endosteal estimation	0.8	1.8	2.2	1.4	-1.5	1.4	1.4	-1.3	1.0
Bone: endosteal perimeter	0.5	1.0	1.3	1.1	-1.2	1.0	1.0	-0.9	0.7
Epididymis fat weight	1.6	5.4	6.5	2.3	-2.5	2.4	2.4	-2.3	2.0
Delta time in closed arm before/after self-admin	0.6	0.6	0.7	0.8	-0.8	0.7	0.8	-0.8	0.6
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.4	0.4	-0.2
Diff in mean of infusions in LGA sessions	2.4	2.9	3.2	1.8	-1.8	1.7	1.7	-1.7	1.6
Delay discount exponential model param	0.6	0.7	0.9	0.8	-0.9	0.9	0.9	-0.9	0.1
Extinction: sum of active levers before priming	0.1	0.1	0.1	-0.3	0.3	-0.1	-0.3	0.2	-0.4
Active lever presses in extinction session 6	0.7	0.7	0.9	-0.8	0.8	-0.8	-0.9	1.0	-0.7
Bone: final force	2.2	3.5	4.0	1.9	-2.0	2.0	1.9	-1.9	1.5
Bone: final moment	2.1	3.3	3.9	1.9	-1.9	2.0	1.9	-1.8	1.4
Food consumed during 24 hour testing period	0.0	0.0	0.0	0.2	-0.1	0.0	0.1	-0.1	0.1
Glucose	0.6	0.9	1.1	1.0	-1.1	0.9	1.0	-0.8	0.9
Heart weight	0.1	0.1	0.3	0.5	-0.3	0.0	0.1	0.0	-0.4
Delay discount hyperbolic model param	0.6	0.7	0.9	0.9	-0.9	0.9	0.9	-0.9	0.1
Intermittent access intake day 1-15 change	0.1	0.2	0.5	-0.7	0.4	-0.3	-0.4	0.4	-0.2
Intermittent access intake escalation	0.2	0.4	0.5	-0.7	0.6	-0.5	-0.6	0.6	-0.5
Intermittent access intake escalation 2	0.2	0.2	0.4	-0.7	0.5	-0.3	-0.4	0.4	-0.4
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.1	-0.2	0.3	0.2	-0.1	0.1
Intermitt. access day 15 inactive lever presses	1.3	2.8	3.0	-1.7	1.7	-1.7	-1.7	1.7	-1.4
Intermitt. access escalation Index	0.7	1.0	1.4	1.2	-1.0	0.8	0.9	-0.9	1.0
Intermittent access day 1 total infusions	1.2	2.0	2.6	-1.5	1.5	-1.6	-1.4	1.4	-0.9
Intermittent access day 15 total infusions	1.4	2.0	2.5	-1.5	1.5	-1.6	-1.5	1.4	-1.0
Intermittent access terminal intake (last 3 days)	0.5	0.6	0.8	-0.9	0.8	-0.9	-0.8	0.8	-0.4
Intermittent access total infusions	0.9	1.1	1.4	-1.2	1.1	-1.2	-1.1	1.1	-0.6
Intermittent access day 1 locomotion	0.6	0.8	1.2	-0.9	1.0	-1.1	-0.9	0.9	-0.4
Intermittent access day 15 total locomotion	0.2	0.4	0.6	-0.8	0.7	-0.8	-0.7	0.7	-0.2
Intermittent access total locomotion	2.6	3.1	3.5	-1.9	1.9	-1.9	-1.8	1.8	-1.3
Intermittent access standard deviation	0.3	0.7	1.1	-1.1	0.8	-0.9	-0.8	0.7	-0.4
Left kidney weight	0.9	4.1	4.5	2.1	-2.1	2.0	2.0	-1.9	2.1
Right kidney weight	1.2	5.2	6.0	2.4	-2.3	2.2	2.2	-2.2	2.4
Cocaine induced anxiety	0.7	1.0	1.2	1.1	-1.1	0.9	1.0	-0.9	0.9
Post-drug Anxiety	3.3	3.6	4.7	2.0	-1.8	1.7	1.8	-1.8	2.2
Baseline Anxiety	1.0	1.1	1.6	1.0	-1.0	0.9	1.0	-1.0	1.3
Tail length	0.5	1.9	2.2	-1.3	1.4	-1.5	-1.4	1.4	-1.2
Length with tail	0.3	1.1	1.7	-1.1	1.2	-1.3	-1.1	1.0	-0.3
Length without tail	0.1	0.4	0.5	-0.7	0.7	-0.7	-0.6	0.5	-0.1
Times rat made contact with spout	1.9	2.2	2.6	1.6	-1.5	1.6	1.5	-1.5	1.1
Lifetime Intake	0.6	0.7	1.0	-1.0	0.9	-1.0	-0.9	0.9	-0.5
Liver weight, left	2.0	3.3	3.4	1.8	-1.8	1.8	1.8	-1.8	1.8
Liver weight, right	2.6	4.5	4.8	2.1	-2.0	2.1	2.1	-2.2	2.2
Locomotor activity	0.1	0.2	0.9	-0.2	0.2	-0.0	-0.2	0.3	-1.0
Locomotor testing distance	0.3	0.5	0.8	0.8	-0.8	0.9	0.7	-0.7	-0.1
Locomotor testing rearing	0.0	0.0	0.1	0.1	-0.2	0.2	0.2	-0.2	-0.1
Locomotion in novel chamber	0.1	0.1	0.2	0.4	-0.4	0.3	0.4	-0.3	0.4
Locomotion in novel chamber post-restriction	0.4	0.6	1.1	-0.7	0.7	-0.8	-0.7	0.6	-1.0
Fecal boli incidents, locomotor time 1	1.3	1.9	2.3	-1.5	1.4	-1.3	-1.5	1.5	-1.0
Change in fecal boli incidents, locomotor task	1.4	1.4	1.8	1.3	-1.3	1.2	1.3	-1.2	0.7
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	-0.5	0.4	-0.3	-0.4	0.5	-0.3
Bouts of movement, locomotor time 1	7.6	8.7	9.5	-3.0	3.1	-3.0	-3.0	2.9	-2.8
Total resting periods, locomotor time 1	7.2	8.0	8.6	-2.9	2.9	-2.8	-2.9	2.8	-2.6
Rest time, locomotor task time 1	1.1	1.4	1.6	-1.3	1.2	-1.1	-1.2	1.2	-1.1
Distance moved, locomotor task time 1	1.7	2.5	3.1	1.6	-1.5	1.4	1.6	-1.7	1.8
Vertical activity count, locomotor time 1	1.7	4.2	4.7	2.1	-2.0	1.9	2.1	-2.2	2.0
Time >=10cm from walls, locomotor time 2	1.3	1.9	3.4	1.1	-1.2	1.3	1.3	-1.4	1.8
Bouts of movement, locomotor time 2	0.2	0.3	0.4	-0.4	0.6	-0.6	-0.5	0.5	-0.4
Total resting periods, locomotor time 2	0.3	0.5	0.6	-0.6	0.8	-0.8	-0.7	0.7	-0.6
Rest time, locomotor task time 2	1.9	2.4	4.4	-1.5	1.4	-1.3	-1.5	1.6	-2.1
Distance moved, locomotor task time 2	3.6	4.3	6.4	2.0	-1.9	1.8	2.0	-2.2	2.5
Vertical activity count, locomotor time 2	4.2	5.8	7.8	2.4	-2.2	2.1	2.4	-2.6	2.8
Light reinforcement 1	0.0	0.0	0.1	-0.1	-0.0	0.2	0.2	-0.3	0.3
Light reinforcement 2	0.2	0.3	0.5	-0.7	0.6	-0.5	-0.6	0.5	-0.2
Bone: marrow area	0.8	1.7	2.0	1.4	-1.4	1.3	1.3	-1.3	0.9
Bone: maximum diameter	0.9	1.7	2.2	1.3	-1.5	1.4	1.3	-1.2	0.9
Bone: maximum force	2.4	4.2	4.8	2.1	-2.1	2.2	2.1	-2.1	1.7
Bone: maximum moment	2.1	3.8	4.3	2.0	-2.1	2.1	2.0	-1.9	1.5
Mean time between licks in bursts	1.1	2.7	3.2	-1.5	1.6	-1.6	-1.6	1.7	-1.8
Mean num. licks in bursts	0.0	0.1	0.2	0.4	-0.3	0.2	0.2	-0.2	0.1
Cd content in liver	0.2	0.2	0.3	0.6	-0.5	0.5	0.5	-0.5	0.3
Co content in liver	1.0	1.2	1.4	-1.0	1.0	-1.1	-1.1	1.2	-1.2
Cu content in liver	2.8	3.3	3.6	-1.8	1.8	-1.8	-1.8	1.9	-1.8
Fe content in liver	0.2	0.2	0.3	0.5	-0.5	0.5	0.5	-0.5	0.4
K content in liver	0.8	0.8	0.9	-0.9	0.8	-0.9	-0.9	1.0	-0.9
Mg content in liver	2.7	2.8	2.9	-1.7	1.7	-1.7	-1.7	1.7	-1.6
Mn content in liver	1.1	1.2	1.4	-1.1	1.2	-1.2	-1.2	1.1	-0.9
Na content in liver	2.0	2.1	2.5	1.4	-1.5	1.4	1.4	-1.4	1.6
Rb content in liver	3.4	4.0	4.8	-2.1	2.2	-2.2	-2.1	2.0	-1.3
Se content in liver	2.5	3.0	3.4	-1.7	1.8	-1.8	-1.7	1.7	-1.5
Sr content in liver	0.6	0.5	0.6	0.7	-0.7	0.7	0.7	-0.7	0.6
Zn content in liver	1.7	1.9	2.1	-1.4	1.4	-1.4	-1.4	1.4	-1.5
Bone: minimum diameter	2.3	4.2	4.9	2.1	-2.2	2.2	2.1	-2.0	1.8
Time in familiar zone, hab. session 1	0.7	0.7	1.1	-0.8	0.7	-0.8	-0.8	0.9	-1.0
Time in novel zone, hab. session 1	1.4	1.4	1.7	1.1	-1.2	1.2	1.2	-1.2	1.3
Total zone transitions, hab. session 1	0.1	0.1	0.1	-0.3	0.2	-0.3	-0.3	0.4	-0.3
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	-0.1	0.0	0.0	0.1	-0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.1	0.2	-0.3
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.2	0.2	-0.3
Time in novel zone, hab. session 2	0.6	0.6	0.7	0.8	-0.8	0.9	0.7	-0.7	0.6
Total zone transitions, hab. session 2	0.8	1.1	1.3	-1.0	1.0	-1.1	-1.1	1.1	-1.0
Total locomotion distance, hab. session 2	0.5	0.7	1.0	-0.7	0.8	-0.8	-0.8	0.9	-1.0
Locomotion velocity, hab. session 2	0.5	0.7	0.9	-0.7	0.7	-0.8	-0.8	0.9	-0.9
Novel to familiar place preference ratio	2.4	2.6	3.0	1.7	-1.7	1.7	1.6	-1.5	1.4
Novelty place preference	2.4	2.6	3.1	1.7	-1.8	1.7	1.6	-1.5	1.4
Time in novel zone, NPP test	1.8	2.0	2.2	1.5	-1.5	1.5	1.4	-1.3	1.3
Total zone transitions, NPP test	4.4	6.4	6.6	-2.5	2.5	-2.6	-2.5	2.6	-2.5
Total locomotion distance, NPP test	2.3	3.1	3.3	-1.6	1.7	-1.7	-1.8	1.8	-1.8
Locomotion velocity, NPP test	2.2	3.0	3.9	-1.6	1.6	-1.7	-1.7	1.8	-2.0
Intraocular pressure	0.2	0.2	0.4	0.4	-0.5	0.4	0.5	-0.4	0.6
Delta distance traveled before/after self-admin	0.3	0.4	0.6	0.5	-0.7	0.7	0.7	-0.6	0.3
Delta ambulatory time before/after self-admin	1.2	1.5	1.9	1.2	-1.4	1.4	1.3	-1.3	0.9
Parametrial fat weight	0.1	0.4	0.6	-0.5	0.6	-0.6	-0.7	0.7	-0.4
Pavlov. Cond. lever latency	1.5	1.9	2.3	-1.4	1.3	-1.3	-1.3	1.4	-1.5
Pavlov. Cond. magazine entry latency	4.5	5.8	7.1	2.3	-2.3	2.3	2.4	-2.5	2.7
Pavlov. Cond. change in total contacts	3.2	3.4	3.8	1.8	-1.7	1.8	1.8	-1.9	2.0
Pavlov. Cond. index score	3.4	4.3	5.4	2.0	-2.0	2.0	2.0	-2.1	2.3
Pavlov. Cond. latency score	3.1	3.9	4.8	2.0	-1.9	1.9	2.0	-2.0	2.2
Pavlov. Cond. lever contacts	1.8	2.1	2.6	1.5	-1.4	1.4	1.4	-1.5	1.6
Pavlov. Cond. magazine entry number	5.5	7.0	8.2	-2.6	2.5	-2.6	-2.6	2.7	-2.9
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	-0.6	0.6	-0.6	-0.6	0.7	-0.8
Pavlov. Cond. lever-magazine prob. diff.	3.2	3.9	4.8	2.0	-1.9	1.9	2.0	-2.0	2.2
Pavlov. Cond. response bias	2.5	3.1	4.0	1.8	-1.7	1.7	1.7	-1.8	2.0
Pavlov. Cond. lever latency	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.5	0.5	-0.3
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	0.1	0.1	-0.0	-0.0	-0.0
Pavlov. Cond. change in total contacts	0.3	0.5	0.6	0.6	-0.7	0.7	0.7	-0.7	0.6
Pavlov. Cond. index score	0.3	0.4	0.6	0.6	-0.6	0.7	0.6	-0.7	0.6
Pavlov. Cond. latency score	0.2	0.3	0.5	0.5	-0.5	0.7	0.6	-0.6	0.5
Pavlov. Cond. lever contacts	0.4	0.6	0.7	0.8	-0.8	0.8	0.8	-0.7	0.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.2	0.2	-0.4	-0.3	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	0.4	-0.3	0.2	0.4	-0.5	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	0.6	-0.6	0.7	0.6	-0.7	0.6
Pavlov. Cond. response bias	0.2	0.3	0.5	0.6	-0.6	0.7	0.6	-0.6	0.5
Time in closed arm before self-admin	0.8	1.0	1.3	1.0	-0.9	1.1	0.9	-1.0	1.2
Time in closed arm after self-admin	0.7	0.7	1.0	0.8	-0.8	1.0	0.8	-0.8	0.9
Time in open arm before self-admin	0.1	0.1	0.2	-0.1	0.2	-0.4	-0.3	0.3	-0.3
Time in open arm after self-admin	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	-0.0	0.3
Bone: periosteal estimation	0.8	1.7	2.1	1.3	-1.4	1.4	1.4	-1.3	1.0
Bone: periosteal perimeter	0.6	1.1	1.6	1.1	-1.3	1.1	1.1	-0.9	0.6
Bone: post-yield work	0.1	0.1	0.2	0.5	-0.5	0.4	0.4	-0.2	-0.2
Progressive ratio test 1 active lever presses	0.4	0.4	0.8	-0.7	0.7	-0.9	-0.7	0.6	-0.2
Progressive ratio test 1 breakpoint	0.4	0.5	0.8	-0.7	0.8	-0.9	-0.7	0.6	-0.3
Progressive ratio test 1 inactive lever presses	0.5	0.7	1.1	-1.0	0.9	-0.9	-0.8	0.7	-0.4
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.1	0.0	0.4
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.3	0.1	-0.2	-0.1	0.1	0.4
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	-0.6	0.4	-0.4	-0.4	0.4	0.0
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.2	-0.1	0.1	0.0	0.0	0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.2	-0.1	0.1	0.0	-0.0	0.3
Sum of active levers in priming session hrs 5-6	1.9	1.7	2.6	-1.2	1.4	-1.2	-1.3	1.2	-1.6
Progressive ratio	1.1	1.8	2.3	-1.3	1.3	-1.4	-1.3	1.3	-1.5
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0	0.0	-0.1
Seeking ratio, punishment vs. effort	0.4	0.6	0.9	0.8	-0.7	0.8	0.7	-0.7	0.9
Retroperitoneal fat weight	6.8	28.8	30.4	5.3	-5.5	5.4	5.4	-5.3	5.3
Reaction time number correct	0.4	0.9	1.1	1.0	-0.9	0.8	0.9	-1.0	0.8
Reaction time mean minus median	0.0	0.0	0.0	-0.2	0.0	0.0	-0.1	0.1	0.1
Reaction time mean minus median AUC	0.3	0.7	0.9	0.7	-0.9	0.9	0.8	-0.8	0.8
Reaction time num false alarms	0.0	0.0	0.1	0.2	-0.3	0.2	0.1	0.1	-0.2
Reaction time num false alarms AUC	0.1	0.1	0.2	0.4	-0.4	0.3	0.3	-0.1	0.1
Reaction time trials correct on left	0.4	0.9	1.1	1.0	-0.9	0.8	0.9	-1.0	0.8
Reaction time trials on left	0.5	0.8	1.1	1.0	-0.9	0.8	0.9	-1.0	0.9
Reaction time mean	0.5	0.7	0.9	0.7	-0.8	1.0	0.8	-0.8	1.0
Reaction time mean AUC	0.4	0.6	0.9	0.7	-0.8	0.9	0.8	-0.8	0.9
Median of all reaction times	0.6	0.9	1.1	0.8	-0.9	1.1	0.9	-0.9	1.0
Reaction time omissions	0.0	0.0	0.1	0.2	-0.1	0.1	0.1	-0.2	0.4
Reaction time false alarm rate	0.1	0.2	0.3	-0.3	0.2	-0.3	-0.4	0.6	-0.5
Reaction time premature initiation rate	1.2	1.6	1.8	1.4	-1.3	1.2	1.3	-1.3	1.2
Reaction time premature initiations	1.8	3.2	3.5	1.9	-1.7	1.7	1.8	-1.8	1.7
Std. dev. reaction times	0.3	0.6	0.8	0.7	-0.8	0.9	0.8	-0.7	0.9
Reaction time trials completed	0.5	0.8	1.1	1.0	-0.9	0.8	0.9	-1.0	0.9
Reaction time trials AUC	0.6	1.1	1.4	1.2	-1.0	0.9	1.1	-1.1	1.0
Run reversals in cocaine runway, females	2.6	2.6	2.8	1.6	-1.7	1.6	1.6	-1.5	1.7
Run reversals in cocaine runway, males	0.5	0.5	0.7	-0.6	0.7	-0.6	-0.7	0.7	-0.8
Latency to leave start box in cocaine runway	0.7	0.9	1.2	-1.1	0.9	-0.8	-0.9	0.9	-0.9
Latency to leave start box in cocaine runway, F	1.5	1.7	2.0	-1.4	1.3	-1.3	-1.3	1.3	-1.1
Latency to leave start box in cocaine runway, M	0.8	0.8	1.2	0.7	-1.0	1.1	1.0	-0.9	0.5
Std. dev. time between licks in bursts	0.1	0.2	0.3	0.5	-0.4	0.3	0.4	-0.4	0.4
Total sessions with >9 infusions	0.5	0.6	0.9	-0.9	0.9	-1.0	-0.8	0.7	-0.4
Short access day 1 total inactive lever presses	0.8	1.0	1.3	-0.9	1.0	-1.0	-1.0	1.0	-1.1
Short access day 10 total inactive lever presses	0.1	0.2	0.3	-0.4	0.4	-0.4	-0.5	0.5	-0.5
Short access day 1 total infusions	0.5	0.7	1.0	-0.9	1.0	-0.9	-0.9	0.8	-0.4
Short access day 10 total infusions	0.7	1.0	1.3	-1.1	1.0	-1.1	-1.0	1.0	-0.6
Short access total infusions	0.6	0.7	1.0	-1.0	0.9	-0.9	-0.9	0.8	-0.4
Short access day 1 locomotion	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.3	0.2	0.2
Short access day 10 total locomotion	1.8	3.3	3.5	-1.8	1.8	-1.9	-1.8	1.8	-1.7
Short access total locomotion	0.4	0.5	0.7	-0.7	0.7	-0.8	-0.7	0.7	-0.4
One hour access (0.3 mA shock)	0.4	0.5	0.8	-0.9	0.7	-0.7	-0.7	0.7	-0.4
Compulsive drug intake	0.2	0.2	0.4	-0.4	0.3	-0.3	-0.4	0.5	-0.6
One hour access (shock baseline)	0.0	0.0	0.1	-0.1	-0.1	0.0	0.1	-0.1	0.4
Social response proportion	2.2	2.5	5.0	1.5	-1.3	1.3	1.4	-1.6	2.2
Social responses	1.6	2.1	3.8	1.4	-1.2	1.1	1.3	-1.5	1.9
Social time	0.7	0.9	1.2	-1.0	0.9	-1.1	-1.0	1.0	-0.8
Soleus weight	0.3	0.8	1.2	1.1	-1.0	0.8	0.9	-0.8	0.6
Bone: stiffness	3.5	5.8	6.6	2.5	-2.5	2.6	2.5	-2.4	1.9
Tibialis anterior weight	0.1	0.2	0.3	-0.4	0.4	-0.4	-0.4	0.3	-0.6
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	0.3	-0.3	0.4	0.3	-0.4	0.7
Time to tail flick, vehicle, after self-admin	2.4	3.2	3.6	1.9	-1.8	1.7	1.7	-1.7	1.9
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.3	-0.4	0.5	0.5	-0.5	0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.3	0.4	-0.4	-0.4	0.3	-0.4
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.5	1.2	-1.0	0.9	1.0	-1.0	0.8
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.0	0.2	-0.3	-0.2	0.3	-0.3
Tibia length	0.0	0.1	0.2	-0.5	0.3	-0.3	-0.3	0.3	-0.4
Ambulatory time before self-admin	1.6	2.3	3.0	-1.7	1.7	-1.6	-1.6	1.5	-1.0
Ambulatory time after self-admin	0.0	0.0	0.1	-0.1	0.1	0.1	-0.0	-0.1	0.3
Bone: tissue strength	0.5	0.5	0.8	-0.7	0.6	-0.6	-0.6	0.7	-0.9
Total heroin consumption	1.7	2.0	2.2	-1.4	1.5	-1.4	-1.5	1.5	-1.4
Bone: trabecular number	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.2	0.1	0.2
Bone: trabecular spacing	1.8	2.4	2.6	1.5	-1.6	1.6	1.5	-1.5	1.6
Bone: trabecular thickness	0.0	0.0	0.1	-0.2	0.3	-0.3	-0.2	0.2	-0.1
Bone: trabecular tissue density	0.2	0.3	0.4	-0.6	0.6	-0.5	-0.6	0.5	-0.6
Water consumed over 24 hours	1.3	1.7	2.0	1.3	-1.2	1.4	1.3	-1.4	1.3
Number of responses in last shaping day	0.2	0.2	0.4	0.6	-0.4	0.3	0.4	-0.4	0.6