Hub : Genes

Skic2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Skic2 0.19 0.08 1.4e-12 0.14 0.15 0.15 0.15 3.8e-11 2.0e-12 6.5e-12 6.6e-12
2 BLA gene expression Skic2 0.3 0.11 2.4e-10 0.13 0.16 0.12 0.12 2.8e-07 1.1e-08 1.1e-06 6.5e-07
3 PL gene expression Skic2 0.18 0.07 1.5e-15 0.11 0.14 0.15 0.15 2.8e-12 1.6e-15 4.9e-16 9.7e-16
4 NAcc gene expression Skic2 0.17 0.08 1.1e-16 0.1 0.11 0.1 0.1 3.2e-15 2.6e-16 1.4e-14 3.5e-15
5 IC gene expression Skic2 0.23 0.1 4.5e-07 0.06 0.17 0.16 0.17 1.5e-03 1.8e-07 5.0e-07 1.8e-07
6 Brain gene expression Skic2 0.29 0.11 1.1e-15 0.14 0.16 0.16 0.17 5.3e-13 5.2e-15 2.8e-14 2.7e-15
7 NAcc mRNA stability Skic2 0.02 0.01 7.6e-03 0.01 0.01 0 0.01 2.4e-03 2.1e-02 8.1e-02 3.1e-02
8 Adipose gene expression Skic2 0.1 0.05 4.7e-09 0.08 0.08 0.08 0.07 5.5e-09 5.9e-09 1.9e-09 8.5e-08
9 Liver gene expression Skic2 0.08 0.04 5.4e-08 0.07 0.06 0.07 0.07 2.6e-08 1.9e-07 3.2e-08 3.1e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.64.56.22.42.02.42.42.51.61.92.01.6
Area under the delay curve0.50.61.4-0.9-0.6-0.8-1.0-0.5-0.9-0.2-1.2-0.4
BMI with tail1.03.46.81.72.01.71.31.72.41.22.61.4
BMI without tail0.20.52.5-0.30.3-0.3-0.1-0.51.60.5-0.2-1.1
Body weight0.20.92.0-1.3-0.5-0.9-1.4-1.01.0-1.20.3-0.1
Weight adjusted by age0.91.33.0-1.7-1.3-1.0-1.3-1.1-0.6-1.0-1.0-0.9
Bone surface0.00.10.2-0.2-0.3-0.2-0.2-0.1-0.2-0.40.40.3
Bone volume0.40.71.00.80.70.90.90.90.80.61.00.6
Breakpoint value in progressive ratio session0.00.00.1-0.1-0.30.0-0.30.1-0.4-0.10.1-0.0
Number of licking bursts1.22.03.4-1.3-1.5-1.5-1.6-1.5-1.8-1.8-0.5-0.1
Context. condit. distance diff. score1.31.53.8-0.4-1.2-0.4-0.6-0.3-1.9-1.90.81.8
Locomotion velocity, session 11.01.12.0-1.0-1.3-1.1-0.6-1.0-1.2-0.7-1.4-0.8
Locomotion distance, session 11.21.52.51.41.11.41.31.60.81.21.11.0
Locomotion velocity, session 20.30.30.8-0.4-0.5-0.5-0.6-0.6-0.9-0.7-0.2-0.0
Locomotion distance, session 20.91.32.91.20.91.20.81.40.10.31.51.7
Locomotion velocity, session 30.30.30.90.20.40.10.40.00.70.9-0.5-0.9
Locomotion distance, session 30.60.61.11.00.70.91.00.90.30.80.60.6
Stereotopy head waving bouts, day 32.32.74.0-1.8-1.6-1.9-2.0-1.9-1.5-1.8-1.2-0.8
Stereotopy head waving duration, day 32.52.94.4-2.0-1.7-1.9-1.7-2.1-1.2-1.3-1.8-1.5
Locomotion velocity, session 73.33.67.42.11.52.21.72.20.30.62.42.7
Locomotion distance, session 71.82.23.61.91.21.81.81.70.20.71.41.7
Stereotopy head waving bouts, day 72.52.85.9-1.5-1.2-1.8-1.2-2.0-0.8-0.5-2.4-2.4
Stereotopy head waving duration, day 71.41.74.1-1.2-0.9-1.4-1.0-1.5-0.5-0.2-1.9-2.0
Locomotion velocity, session 84.65.59.2-2.4-2.7-2.4-2.6-2.3-3.0-2.9-1.3-0.3
Locomotion distance, session 81.42.08.50.6-0.30.70.11.0-1.4-1.32.02.9
Degree of sensitization distance0.70.71.8-0.7-0.9-0.8-0.9-0.7-1.2-1.4-0.10.3
Degree of sensitization stereotypy1.11.23.5-0.8-0.7-1.1-0.5-1.2-0.40.1-1.8-1.9
Conditioned locomotion0.20.20.5-0.4-0.3-0.2-0.6-0.0-0.3-0.60.60.7
Cocaine response after cond. corrected1.51.85.71.10.81.20.51.40.1-0.22.42.2
Cocaine response after cond. not corrected0.60.71.7-0.7-0.7-0.7-1.1-0.5-0.9-1.30.50.6
Cocaine response before conditioning7.08.311.9-3.1-2.5-3.3-2.8-3.4-1.5-1.8-3.4-3.2
Saline control response1.01.34.20.10.90.00.6-0.21.81.4-1.0-2.1
Bone: connectivity density2.23.45.02.01.62.11.92.21.11.22.22.0
Bone: cortical apparent density1.41.93.71.41.71.21.31.21.91.51.10.3
Bone: cortical area0.30.40.8-0.6-0.5-0.9-0.8-0.8-0.4-0.7-0.3-0.3
Bone: cortical porosity4.34.612.4-1.9-1.7-2.1-1.3-2.3-1.2-0.5-3.5-3.1
Bone: cortical porosity5.25.713.1-2.3-2.1-2.5-1.6-2.6-1.7-1.1-3.6-2.9
Bone: cortical thickness0.81.32.81.21.60.91.10.91.71.40.6-0.1
Bone: cortical thickness1.82.24.51.62.01.31.31.22.11.51.00.0
Bone: cortical tissue density1.11.63.21.21.61.11.21.11.81.41.00.2
Condit. Reinf. active minus inactive responses0.30.31.2-0.2-0.2-0.3-0.1-0.4-0.50.3-1.1-0.9
Condit. Reinf. active-inactive response ratio0.30.31.2-0.00.3-0.10.1-0.30.30.6-0.8-1.1
Condit. Reinf. active responses0.20.30.60.70.60.70.70.60.10.80.10.1
Condit. Reinf. inactive responses2.73.34.62.11.82.12.02.11.21.71.81.4
Incentive salience index mean0.20.31.7-0.2-0.5-0.3-0.4-0.1-1.3-0.5-0.10.4
Condit. Reinf. lever presses0.91.24.70.1-0.50.2-0.30.6-1.6-1.11.42.2
Condit. Reinf. active minus inactive responses1.31.72.6-1.5-1.2-1.5-1.1-1.5-0.6-0.7-1.6-1.5
Condit. Reinf. active-inactive response ratio2.73.14.2-2.0-1.9-2.0-1.7-2.1-1.3-1.5-1.8-1.5
Condit. Reinf. active responses0.30.41.0-0.7-0.6-0.6-0.4-0.7-0.10.0-1.0-1.0
Condit. Reinf. inactive responses0.50.61.10.80.90.80.80.81.01.10.4-0.0
Condit. Reinf. lever presses0.20.31.3-0.3-0.5-0.40.2-0.3-0.10.4-1.2-1.0
Condit. Reinf. lever reinforcers received0.50.71.6-0.8-0.8-0.9-0.5-0.9-0.3-0.1-1.3-1.2
Conditioned reinforcement - actives0.30.40.80.60.50.80.70.90.70.70.6-0.1
Conditioned reinforcement - inactives0.10.20.50.20.10.60.50.50.30.7-0.1-0.5
Conditioned locomotion0.00.00.1-0.2-0.2-0.20.20.2-0.1-0.10.2-0.2
Patch foraging indifference point 0 sec0.40.82.90.30.80.60.60.31.71.2-0.1-1.0
Patch foraging indifference point AUC1.11.73.5-1.1-0.9-1.7-1.0-1.6-1.1-0.6-1.2-1.9
Delay disc. indifference point, 0s delay0.40.41.2-0.6-0.7-0.5-0.9-0.2-1.1-0.7-0.00.4
Delay disc. indifference point, 16s delay0.20.20.70.20.40.20.30.20.30.8-0.5-0.2
Delay disc. indifference point, 2s delay2.42.74.2-2.0-1.8-1.4-2.0-1.3-1.9-1.1-1.8-1.1
Delay disc. indifference point, 24s delay1.31.44.9-1.1-0.7-1.0-0.8-1.1-0.60.0-2.2-1.6
Delay disc. indifference point, 4s delay1.21.22.4-1.4-1.0-1.1-1.5-0.8-1.0-0.4-1.3-1.0
Delay disc. indifference point, 8s delay0.20.30.8-0.4-0.2-0.7-0.5-0.3-0.7-0.1-0.9-0.2
Indifference point function ln k0.30.61.0-0.9-1.0-0.6-1.0-0.5-0.7-0.9-0.8-0.2
Indifference point function log k0.30.61.0-0.9-1.0-0.6-1.0-0.5-0.7-0.9-0.8-0.2
Patch foraging total patch changes 0 sec0.50.93.10.40.90.60.70.31.81.3-0.1-1.0
Patch foraging total patch changes 12 sec0.40.52.00.10.60.10.4-0.10.91.1-0.3-1.4
Patch foraging total patch changes 18 sec2.84.37.32.12.62.12.11.92.72.31.70.1
Patch foraging total patch changes 24 sec2.03.45.02.12.21.82.21.72.02.21.20.3
Patch foraging total patch changes 6 sec0.50.82.30.61.10.50.90.41.31.5-0.0-0.9
Patch foraging time to switch 0 sec2.34.77.52.12.12.51.72.51.61.42.72.5
Patch foraging water rate 0 sec0.10.30.5-0.6-0.3-0.7-0.5-0.7-0.0-0.5-0.7-0.6
Patch foraging water rate 12 sec0.30.71.21.11.10.81.00.61.10.80.50.4
Patch foraging water rate 18 sec0.00.10.30.10.4-0.00.2-0.20.50.2-0.2-0.2
Patch foraging water rate 24 sec0.20.31.20.50.60.70.40.51.10.60.1-0.1
Patch foraging water rate 6 sec0.20.30.60.60.80.50.40.40.70.40.30.0
Seeking ratio, delayed vs. immediate footshock0.81.02.6-0.8-0.4-1.1-1.0-1.40.30.0-1.2-1.6
Distance traveled before self-admin0.40.52.40.20.10.5-0.10.30.2-0.61.61.1
Distance traveled after self-admin0.60.71.3-1.0-0.7-0.9-1.2-1.1-0.0-0.7-0.5-0.9
Extensor digitorum longus weight0.20.81.8-0.9-1.1-0.7-0.9-0.7-0.9-1.3-0.10.5
Bone: elastic displacement0.30.40.80.30.40.20.7-0.10.50.8-0.9-0.9
Bone: elastic work0.10.10.3-0.20.0-0.2-0.1-0.40.0-0.0-0.5-0.5
Bone: endosteal estimation4.710.314.8-3.8-3.7-3.4-3.8-3.4-2.9-3.6-2.0-1.2
Bone: endosteal perimeter3.06.410.0-2.8-2.9-2.7-3.0-2.4-2.9-3.2-1.0-0.1
Epididymis fat weight7.927.039.35.46.05.55.15.16.35.14.92.7
Delta time in closed arm before/after self-admin0.20.10.6-0.2-0.2-0.3-0.30.1-0.1-0.40.40.8
Delta time in open arm before/after self-admin0.40.31.20.30.40.60.50.20.70.7-0.3-1.1
Diff in mean of infusions in LGA sessions1.41.75.91.30.90.90.81.20.10.21.82.4
Delay discount exponential model param0.80.92.01.10.71.01.10.71.00.21.40.7
Extinction: sum of active levers before priming0.60.61.1-0.6-0.8-0.8-0.7-0.7-1.1-1.00.30.7
Active lever presses in extinction session 60.50.51.00.70.60.81.00.80.50.70.30.5
Bone: final force0.30.41.30.40.90.50.20.31.2-0.01.10.4
Bone: final moment0.20.31.10.30.70.40.20.21.00.00.80.3
Food consumed during 24 hour testing period0.40.51.3-0.3-0.3-0.1-0.8-0.0-0.5-1.11.01.2
Glucose5.79.015.4-3.1-3.6-3.0-3.0-2.8-3.9-3.6-1.9-0.2
Heart weight2.53.96.5-2.3-1.8-2.3-1.9-2.2-1.2-0.9-2.5-1.9
Delay discount hyperbolic model param1.01.22.51.30.91.01.30.81.10.31.60.9
Intermittent access intake day 1-15 change0.10.20.5-0.1-0.0-0.6-0.1-0.70.4-0.0-0.3-0.6
Intermittent access intake escalation0.20.41.10.30.5-0.40.4-0.41.00.7-0.4-1.0
Intermittent access intake escalation 20.30.41.2-0.4-0.4-1.1-0.4-1.0-0.2-0.2-0.6-0.5
Intermitt. access day 1 inactive lever presses0.31.32.9-1.1-1.3-0.6-1.5-0.6-1.7-1.50.30.9
Intermitt. access day 15 inactive lever presses0.10.10.3-0.5-0.4-0.4-0.5-0.4-0.2-0.3-0.3-0.0
Intermitt. access escalation Index0.40.62.00.70.20.60.11.0-0.4-0.21.31.4
Intermittent access day 1 total infusions0.50.82.00.70.31.41.21.30.31.00.20.2
Intermittent access day 15 total infusions0.40.71.50.70.70.71.10.70.91.2-0.0-0.7
Intermittent access terminal intake (last 3 days)0.30.41.20.10.10.20.70.20.51.0-0.6-1.1
Intermittent access total infusions0.40.51.10.40.30.80.90.70.51.0-0.3-0.7
Intermittent access day 1 locomotion0.91.12.40.90.81.31.21.60.91.11.00.6
Intermittent access day 15 total locomotion0.00.10.3-0.00.2-0.30.1-0.10.50.10.2-0.3
Intermittent access total locomotion0.30.40.80.50.60.40.80.60.90.80.3-0.3
Intermittent access standard deviation0.20.31.40.10.60.10.3-0.11.20.7-0.0-0.9
Left kidney weight0.10.52.5-0.70.1-0.3-0.7-0.41.60.3-0.2-0.8
Right kidney weight0.10.32.3-0.50.3-0.2-0.5-0.21.50.10.2-0.2
Cocaine induced anxiety0.30.41.6-0.1-0.2-0.0-0.50.1-0.5-0.61.01.3
Post-drug Anxiety0.20.20.5-0.3-0.3-0.2-0.5-0.2-0.3-0.50.60.7
Baseline Anxiety0.10.10.4-0.3-0.1-0.5-0.2-0.60.1-0.1-0.5-0.5
Tail length3.814.720.2-4.5-3.9-4.3-4.0-4.5-2.3-3.3-4.0-3.1
Length with tail2.711.717.9-4.2-3.5-3.8-4.0-3.9-2.1-3.6-2.9-1.9
Length without tail0.61.95.2-1.6-1.1-1.0-2.1-0.9-0.5-2.30.71.1
Times rat made contact with spout1.31.53.61.31.41.01.40.71.31.9-0.4-1.0
Lifetime Intake0.30.40.90.30.20.80.80.70.41.0-0.3-0.6
Liver weight, left2.03.26.1-2.1-2.1-1.9-2.4-1.7-1.3-2.5-0.50.1
Liver weight, right3.05.39.0-2.6-2.7-2.1-2.8-2.3-2.4-3.0-0.9-0.1
Locomotor activity1.82.84.1-2.0-1.7-1.8-1.9-2.0-0.8-1.2-1.6-1.8
Locomotor testing distance0.51.01.8-1.3-1.2-1.0-1.4-0.9-0.7-0.9-0.4-0.7
Locomotor testing rearing0.20.41.1-0.8-0.8-0.4-0.9-0.6-0.3-1.10.20.1
Locomotion in novel chamber0.10.10.20.20.30.20.00.10.40.30.50.2
Locomotion in novel chamber post-restriction0.10.10.70.10.40.30.10.40.80.30.3-0.2
Fecal boli incidents, locomotor time 10.60.92.00.80.51.11.11.00.50.41.41.3
Change in fecal boli incidents, locomotor task2.62.54.2-1.7-1.4-1.9-2.0-1.8-1.5-1.7-1.0-0.8
Time >=10cm from walls, locomotor time 10.91.02.0-0.8-0.7-0.6-1.3-0.5-0.6-1.41.01.4
Bouts of movement, locomotor time 10.10.10.30.30.20.20.10.2-0.20.2-0.1-0.5
Total resting periods, locomotor time 10.10.10.30.0-0.0-0.1-0.1-0.0-0.3-0.0-0.3-0.6
Rest time, locomotor task time 10.40.50.9-0.8-1.0-0.5-0.6-0.7-0.8-0.7-0.4-0.1
Distance moved, locomotor task time 10.00.10.10.00.30.1-0.10.10.30.2-0.2-0.4
Vertical activity count, locomotor time 10.20.41.10.51.10.80.20.51.00.70.1-0.2
Time >=10cm from walls, locomotor time 21.01.52.7-1.6-1.2-1.4-1.6-1.0-1.0-1.4-0.7-0.1
Bouts of movement, locomotor time 20.50.91.7-1.0-0.8-1.0-1.0-1.1-0.6-0.2-1.3-1.0
Total resting periods, locomotor time 21.11.93.1-1.4-1.3-1.5-1.5-1.6-1.1-0.7-1.8-1.3
Rest time, locomotor task time 20.81.02.2-0.6-1.0-0.5-1.1-0.7-1.3-1.50.61.4
Distance moved, locomotor task time 20.50.61.10.61.10.61.01.01.10.9-0.1-0.3
Vertical activity count, locomotor time 20.20.30.50.20.70.40.40.70.70.6-0.2-0.2
Light reinforcement 10.41.02.91.01.10.70.50.71.10.21.71.3
Light reinforcement 20.30.52.20.30.30.2-0.10.30.3-0.51.51.3
Bone: marrow area4.610.114.6-3.8-3.6-3.4-3.7-3.4-2.8-3.6-2.0-1.2
Bone: maximum diameter2.13.85.7-2.1-2.2-2.1-2.3-1.9-2.4-2.3-0.9-0.1
Bone: maximum force0.10.20.50.10.40.2-0.10.20.7-0.10.70.4
Bone: maximum moment0.00.10.2-0.10.10.1-0.10.10.5-0.20.40.3
Mean time between licks in bursts1.43.35.5-1.8-2.3-1.9-1.7-1.8-2.3-2.3-0.9-0.2
Mean num. licks in bursts2.23.46.91.82.11.82.11.62.32.60.2-0.5
Cd content in liver2.73.04.21.81.62.11.72.01.31.11.91.9
Co content in liver0.70.81.70.81.11.00.80.91.30.90.80.5
Cu content in liver1.92.24.51.71.81.61.61.41.52.10.7-0.2
Fe content in liver0.91.12.11.01.21.11.10.91.41.10.90.4
K content in liver0.30.30.60.60.30.60.50.60.00.20.70.8
Mg content in liver1.11.12.7-0.8-1.2-0.9-1.1-0.6-1.6-1.60.20.8
Mn content in liver2.62.96.7-1.4-1.8-1.5-1.9-1.2-2.4-2.60.21.1
Na content in liver0.20.20.70.40.50.10.20.00.40.7-0.2-0.8
Rb content in liver0.60.71.90.70.40.80.71.00.3-0.01.21.4
Se content in liver4.95.77.7-2.3-2.6-2.6-2.6-2.7-2.8-2.6-1.8-1.1
Sr content in liver0.30.30.6-0.7-0.6-0.5-0.4-0.5-0.6-0.8-0.50.1
Zn content in liver0.20.20.5-0.3-0.5-0.2-0.3-0.1-0.5-0.70.10.5
Bone: minimum diameter2.44.47.8-2.2-2.3-2.3-2.5-2.1-2.2-2.8-0.70.0
Time in familiar zone, hab. session 13.13.05.32.01.91.82.31.51.82.30.4-0.1
Time in novel zone, hab. session 12.62.64.3-2.0-1.8-1.8-2.1-1.5-1.5-1.8-0.9-0.4
Total zone transitions, hab. session 10.10.10.30.30.10.20.10.4-0.10.10.50.4
Total locomotion distance, hab. session 10.30.41.00.60.30.60.40.80.10.11.01.0
Locomotion velocity, hab. session 10.10.10.30.30.10.20.20.4-0.00.00.60.5
Time in familiar zone, hab. session 20.70.81.71.01.20.80.80.61.30.90.7-0.2
Time in novel zone, hab. session 20.40.41.2-0.8-0.7-0.6-0.4-0.6-0.6-0.3-1.1-0.5
Total zone transitions, hab. session 20.70.92.70.90.80.90.51.10.50.31.61.2
Total locomotion distance, hab. session 21.82.36.01.61.21.51.01.70.60.42.42.1
Locomotion velocity, hab. session 21.51.95.31.41.01.30.81.50.30.22.32.1
Novel to familiar place preference ratio0.10.10.4-0.2-0.2-0.3-0.0-0.2-0.30.0-0.6-0.4
Novelty place preference0.30.30.9-0.5-0.5-0.6-0.3-0.6-0.5-0.2-1.0-0.7
Time in novel zone, NPP test0.60.61.5-0.7-0.7-0.8-0.4-0.9-0.6-0.4-1.2-1.0
Total zone transitions, NPP test0.81.12.21.10.61.11.01.40.20.51.31.5
Total locomotion distance, NPP test2.43.26.41.81.32.01.62.30.60.82.32.5
Locomotion velocity, NPP test3.14.48.72.11.52.31.82.60.70.92.72.9
Intraocular pressure1.42.02.91.51.51.51.71.51.51.41.10.6
Delta distance traveled before/after self-admin2.52.76.3-1.7-1.2-1.6-1.3-1.7-0.5-0.2-2.5-2.5
Delta ambulatory time before/after self-admin2.42.96.3-1.7-1.3-1.8-1.5-1.8-0.7-0.5-2.5-2.4
Parametrial fat weight1.94.57.62.12.42.21.72.42.11.52.81.8
Pavlov. Cond. lever latency2.12.77.11.52.21.61.31.32.71.61.30.1
Pavlov. Cond. magazine entry latency2.93.75.0-1.7-2.0-2.1-1.6-2.1-2.2-1.6-2.1-1.5
Pavlov. Cond. change in total contacts2.32.53.2-1.5-1.7-1.7-1.4-1.8-1.8-1.3-1.6-1.2
Pavlov. Cond. index score2.83.67.4-1.7-2.2-2.0-1.7-1.9-2.7-2.0-1.6-0.6
Pavlov. Cond. latency score3.03.87.9-1.8-2.3-2.0-1.7-1.9-2.8-2.0-1.6-0.6
Pavlov. Cond. lever contacts1.82.16.2-1.3-1.9-1.3-1.3-1.0-2.5-1.7-0.60.5
Pavlov. Cond. magazine entry number1.82.33.11.41.61.61.21.71.81.31.61.1
Pavlov. Cond. intertrial magazine entries3.84.66.02.22.22.52.22.42.22.21.81.3
Pavlov. Cond. lever-magazine prob. diff.2.63.26.8-1.6-2.1-1.8-1.5-1.8-2.6-1.9-1.5-0.5
Pavlov. Cond. response bias2.02.55.1-1.4-1.9-1.6-1.4-1.6-2.3-1.6-1.3-0.5
Pavlov. Cond. lever latency0.40.51.2-0.4-0.5-0.4-0.8-0.3-0.8-1.10.70.9
Pavlov. Cond. magazine entry latency0.20.30.5-0.5-0.7-0.5-0.2-0.6-0.6-0.7-0.6-0.2
Pavlov. Cond. change in total contacts0.40.62.1-0.4-0.3-0.50.1-0.60.20.5-1.4-1.4
Pavlov. Cond. index score0.20.31.2-0.3-0.4-0.40.1-0.5-0.10.1-1.1-0.9
Pavlov. Cond. latency score0.20.31.1-0.3-0.3-0.40.1-0.4-0.00.2-1.0-0.9
Pavlov. Cond. lever contacts0.30.41.00.40.40.30.70.30.71.0-0.6-0.8
Pavlov. Cond. magazine entry number0.00.00.1-0.10.1-0.1-0.30.00.00.20.1-0.1
Pavlov. Cond. intertrial magazine entries0.60.81.5-0.9-1.0-1.0-1.1-0.9-1.2-0.8-0.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.9-0.2-0.3-0.30.2-0.3-0.10.1-0.9-0.8
Pavlov. Cond. response bias0.10.10.50.1-0.0-0.00.4-0.10.00.3-0.7-0.6
Time in closed arm before self-admin0.30.40.7-0.8-0.8-0.8-0.7-0.7-0.6-0.6-0.5-0.1
Time in closed arm after self-admin0.10.10.7-0.1-0.2-0.0-0.10.2-0.1-0.20.40.9
Time in open arm before self-admin0.40.51.4-0.6-0.7-0.6-0.4-0.7-0.7-0.2-1.2-0.7
Time in open arm after self-admin0.50.52.0-0.5-0.5-0.4-0.1-0.6-0.00.2-1.2-1.4
Bone: periosteal estimation2.65.58.0-2.8-2.5-2.6-2.8-2.6-1.9-2.6-1.4-1.0
Bone: periosteal perimeter2.13.65.0-2.1-2.0-2.2-2.2-2.0-2.0-2.1-1.1-0.6
Bone: post-yield work0.91.32.4-1.2-1.5-1.0-1.2-0.6-1.3-1.60.10.9
Progressive ratio test 1 active lever presses0.10.20.80.0-0.10.90.30.60.00.40.00.1
Progressive ratio test 1 breakpoint0.10.10.7-0.0-0.20.80.30.60.00.4-0.00.0
Progressive ratio test 1 inactive lever presses1.42.02.91.41.31.71.31.71.21.31.51.3
Progressive ratio test 2 active lever presses0.50.60.90.90.70.81.00.90.60.90.70.0
Progressive ratio test 2 breakpoint0.60.61.10.90.70.81.00.90.71.00.6-0.1
Progressive ratio test 2 inactive lever presses0.10.10.5-0.3-0.7-0.1-0.00.1-0.6-0.2-0.10.4
Incentive Sensitization - Responses0.10.10.20.40.2-0.10.30.10.20.30.3-0.3
Incentive Sensitization - Breakpoint0.20.20.50.70.50.20.60.40.40.50.6-0.2
Sum of active levers in priming session hrs 5-60.60.61.3-0.8-0.9-0.6-0.5-0.8-0.7-0.5-1.2-0.7
Progressive ratio0.20.41.6-0.10.50.1-0.3-0.41.30.6-0.1-0.8
Food seeking constrained by brief footshock0.10.10.30.20.30.20.40.00.40.5-0.6-0.5
Seeking ratio, punishment vs. effort0.30.41.7-0.4-0.8-0.7-0.1-0.3-1.3-0.5-0.7-0.1
Retroperitoneal fat weight0.52.24.71.51.41.51.21.51.10.72.21.8
Reaction time number correct0.61.13.00.81.21.01.10.91.71.4-0.2-0.2
Reaction time mean minus median0.20.51.2-0.6-1.1-0.7-0.6-0.4-1.0-1.0-0.30.2
Reaction time mean minus median AUC0.10.30.8-0.3-0.9-0.3-0.2-0.1-0.9-0.9-0.30.6
Reaction time num false alarms0.81.12.0-0.9-1.0-1.3-1.1-1.4-0.9-1.3-0.6-0.4
Reaction time num false alarms AUC1.42.13.5-1.4-1.4-1.8-1.6-1.9-1.2-1.4-1.2-1.1
Reaction time trials correct on left0.61.13.00.81.21.01.10.91.71.4-0.2-0.2
Reaction time trials on left0.51.02.80.81.10.91.00.81.71.4-0.2-0.2
Reaction time mean0.60.92.4-0.5-1.0-0.3-0.70.0-1.4-1.50.51.3
Reaction time mean AUC0.50.82.1-0.4-1.0-0.2-0.60.0-1.2-1.40.51.3
Median of all reaction times0.50.82.0-0.3-0.8-0.1-0.60.2-1.2-1.40.71.4
Reaction time omissions0.50.71.6-0.5-0.9-0.3-0.7-0.1-1.1-1.30.61.1
Reaction time false alarm rate2.83.95.1-1.9-2.1-2.3-2.2-2.3-2.2-2.1-1.3-1.0
Reaction time premature initiation rate0.00.00.1-0.3-0.2-0.1-0.10.20.0-0.00.10.0
Reaction time premature initiations0.20.31.00.10.50.30.40.61.00.8-0.0-0.1
Std. dev. reaction times1.12.13.5-1.4-1.9-1.5-1.4-1.2-1.8-1.8-0.9-0.1
Reaction time trials completed0.51.02.80.81.10.91.00.81.71.4-0.2-0.2
Reaction time trials AUC0.61.12.90.91.21.01.10.91.71.3-0.0-0.0
Run reversals in cocaine runway, females0.80.81.40.90.90.91.11.20.90.90.70.6
Run reversals in cocaine runway, males0.30.30.7-0.6-0.8-0.5-0.6-0.6-0.8-0.7-0.30.0
Latency to leave start box in cocaine runway0.50.61.5-0.3-0.6-0.1-0.60.0-1.2-1.00.61.1
Latency to leave start box in cocaine runway, F0.40.41.50.0-0.30.3-0.30.6-0.9-0.50.91.2
Latency to leave start box in cocaine runway, M0.20.20.5-0.3-0.4-0.4-0.6-0.5-0.7-0.7-0.10.3
Std. dev. time between licks in bursts4.66.29.1-2.6-3.0-2.7-2.6-2.5-2.9-3.0-1.4-0.5
Total sessions with >9 infusions0.30.31.4-0.2-0.20.30.20.20.10.6-0.9-1.2
Short access day 1 total inactive lever presses0.50.61.7-1.0-1.2-0.0-0.6-0.2-1.3-0.7-0.8-0.2
Short access day 10 total inactive lever presses0.20.51.70.60.40.7-0.10.5-0.0-0.21.21.3
Short access day 1 total infusions0.20.20.7-0.4-0.50.20.10.2-0.60.1-0.8-0.6
Short access day 10 total infusions0.60.82.00.70.61.41.01.20.51.20.2-0.3
Short access total infusions0.20.30.70.10.00.80.60.70.00.7-0.4-0.4
Short access day 1 locomotion0.10.20.50.40.10.70.20.6-0.20.10.60.3
Short access day 10 total locomotion1.32.54.3-2.0-1.7-1.6-2.1-1.6-1.0-1.4-1.0-1.3
Short access total locomotion0.30.40.7-0.8-0.8-0.5-0.8-0.3-0.6-0.7-0.1-0.1
One hour access (0.3 mA shock)0.50.61.11.00.70.80.70.90.10.71.00.3
Compulsive drug intake1.31.54.6-0.1-0.5-0.5-1.1-0.2-1.3-1.61.82.1
One hour access (shock baseline)1.01.63.11.11.11.21.61.11.31.8-0.3-1.2
Social response proportion1.01.12.2-1.5-1.3-0.8-1.5-0.9-1.1-1.1-0.6-0.3
Social responses0.91.22.2-1.4-1.2-1.1-1.5-1.1-1.0-0.8-0.8-0.9
Social time1.52.04.6-1.1-1.5-1.0-1.8-1.0-1.9-2.10.60.8
Soleus weight3.510.518.9-3.4-3.7-3.5-3.7-2.9-3.7-4.3-1.20.4
Bone: stiffness0.50.82.00.91.10.90.50.81.10.41.40.8
Tibialis anterior weight0.41.42.21.21.31.41.01.11.51.41.00.3
Time to tail flick, vehicle, before self-admin1.11.23.41.31.30.70.50.70.70.21.81.4
Time to tail flick, vehicle, after self-admin0.30.40.9-0.5-0.6-0.5-0.5-0.7-0.9-0.9-0.1-0.4
Time to tail flick, test, before self-admin0.20.20.50.40.50.20.30.30.40.70.1-0.5
Time to tail flick, test, after self-admin0.30.30.80.70.40.90.90.20.50.4-0.1-0.1
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.0-0.20.40.50.3-0.40.3-0.8-0.6
Delta time to tail flick, test, before/after SA1.01.01.81.20.81.31.20.90.80.31.01.1
Tibia length2.15.910.7-2.9-2.6-2.6-2.9-2.7-1.8-3.3-1.0-0.5
Ambulatory time before self-admin0.20.31.40.40.20.70.30.40.3-0.11.20.7
Ambulatory time after self-admin0.80.91.5-1.1-0.9-1.0-1.1-1.2-0.2-0.6-0.8-1.1
Bone: tissue strength0.20.20.50.20.20.60.40.70.30.30.40.6
Total heroin consumption0.10.10.3-0.4-0.4-0.5-0.5-0.3-0.3-0.30.10.1
Bone: trabecular number3.86.38.62.92.42.82.92.91.92.22.31.9
Bone: trabecular spacing3.85.06.8-2.6-2.0-2.6-2.6-2.5-1.6-1.9-2.3-1.8
Bone: trabecular thickness3.74.66.12.42.02.42.32.51.71.72.31.8
Bone: trabecular tissue density1.42.04.9-1.3-1.2-1.4-0.8-1.7-0.6-0.5-2.2-2.0
Water consumed over 24 hours0.40.50.8-0.7-0.7-0.7-0.9-0.7-0.9-0.9-0.3-0.0
Number of responses in last shaping day5.15.67.3-2.7-2.6-2.3-2.5-2.5-2.3-2.1-2.3-1.8