Hub : Genes

Skic2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Skic2 0.19 0.08 1.4e-12 0.14 0.15 0.15 0.15 3.8e-11 2.0e-12 6.5e-12 6.7e-12
2 BLA gene expression Skic2 0.3 0.11 2.4e-10 0.13 0.16 0.12 0.12 2.8e-07 1.1e-08 1.1e-06 6.1e-07
3 PL gene expression Skic2 0.18 0.07 1.5e-15 0.11 0.14 0.15 0.15 2.8e-12 1.6e-15 4.9e-16 1.1e-15
4 NAcc gene expression Skic2 0.17 0.08 1.1e-16 0.1 0.11 0.1 0.1 3.2e-15 2.6e-16 1.4e-14 3.0e-15
5 Brain gene expression Skic2 0.29 0.11 1.1e-15 0.14 0.16 0.16 0.17 5.3e-13 5.2e-15 2.8e-14 2.6e-15
6 NAcc mRNA stability Skic2 0.02 0.01 7.6e-03 0.01 0.01 0 0.01 2.4e-03 2.1e-02 8.1e-02 3.6e-02
7 IC gene expression Skic2 0.23 0.1 4.5e-07 0.06 0.17 0.16 0.16 1.5e-03 1.8e-07 5.0e-07 2.0e-07
8 Adipose gene expression Skic2 0.1 0.05 4.7e-09 0.08 0.08 0.08 0.07 5.5e-09 5.9e-09 1.9e-09 8.7e-08
9 Liver gene expression Skic2 0.08 0.04 5.4e-08 0.07 0.06 0.07 0.07 2.6e-08 1.9e-07 3.2e-08 3.0e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.44.45.92.42.0-2.42.41.6-1.92.3-2.0-1.6
Area under the delay curve0.50.71.4-0.9-0.60.8-1.0-0.90.2-1.01.20.4
BMI with tail1.03.56.81.72.0-1.71.32.4-1.21.9-2.6-1.4
BMI without tail0.10.52.5-0.30.30.3-0.11.6-0.5-0.40.21.1
Body weight0.20.82.0-1.3-0.50.9-1.41.01.2-0.6-0.30.1
Weight adjusted by age0.51.33.0-1.7-1.31.0-1.3-0.61.0-1.21.00.9
Bone surface0.00.10.2-0.2-0.30.2-0.2-0.20.4-0.1-0.4-0.3
Bone volume0.30.61.00.80.7-0.90.90.8-0.60.9-1.0-0.6
Breakpoint value in progressive ratio session0.00.10.1-0.1-0.3-0.0-0.3-0.40.1-0.4-0.10.0
Number of licking bursts0.62.03.4-1.3-1.51.5-1.6-1.81.8-1.30.50.1
Context. condit. distance diff. score1.21.53.8-0.4-1.20.4-0.6-1.91.90.1-0.8-1.8
Locomotion velocity, session 11.01.12.0-1.0-1.31.1-0.6-1.20.7-1.11.40.8
Locomotion distance, session 11.11.41.91.41.1-1.41.30.8-1.21.3-1.1-1.0
Locomotion velocity, session 20.20.30.8-0.4-0.50.5-0.6-0.90.7-0.50.20.0
Locomotion distance, session 20.91.32.91.20.9-1.20.80.1-0.31.3-1.5-1.7
Locomotion velocity, session 30.30.30.90.20.4-0.10.40.7-0.9-0.20.50.9
Locomotion distance, session 30.50.61.11.00.7-0.91.00.3-0.80.8-0.6-0.6
Stereotopy head waving bouts, day 32.22.74.0-1.8-1.61.9-2.0-1.51.8-1.71.20.8
Stereotopy head waving duration, day 32.32.93.9-2.0-1.71.9-1.7-1.21.3-2.01.81.5
Locomotion velocity, session 73.43.77.42.11.5-2.21.70.3-0.62.3-2.4-2.7
Locomotion distance, session 71.82.33.61.91.2-1.81.80.2-0.71.8-1.4-1.7
Stereotopy head waving bouts, day 72.42.85.9-1.5-1.21.8-1.2-0.80.5-2.02.42.4
Stereotopy head waving duration, day 71.41.84.1-1.2-0.91.4-1.0-0.50.2-1.61.92.0
Locomotion velocity, session 84.55.49.2-2.4-2.72.4-2.6-3.02.9-2.11.30.3
Locomotion distance, session 81.42.18.50.6-0.3-0.70.1-1.41.31.3-2.0-2.9
Degree of sensitization distance0.60.71.8-0.7-0.90.8-0.9-1.21.4-0.50.1-0.3
Degree of sensitization stereotypy1.11.23.5-0.8-0.71.1-0.5-0.4-0.1-1.31.81.9
Conditioned locomotion0.20.20.5-0.4-0.30.2-0.6-0.30.60.0-0.6-0.7
Cocaine response after cond. corrected1.21.95.71.10.8-1.20.50.10.21.5-2.4-2.2
Cocaine response after cond. not corrected0.50.71.7-0.7-0.70.7-1.1-0.91.3-0.4-0.5-0.6
Cocaine response before conditioning6.98.311.7-3.1-2.53.3-2.8-1.51.8-3.43.43.2
Saline control response1.01.34.20.10.9-0.10.61.8-1.4-0.31.02.1
Bone: connectivity density2.23.44.92.01.6-2.11.91.1-1.22.2-2.2-2.0
Bone: cortical apparent density1.21.93.71.41.7-1.21.31.9-1.51.3-1.1-0.3
Bone: cortical area0.20.40.8-0.6-0.50.9-0.8-0.40.7-0.70.30.3
Bone: cortical porosity4.44.812.4-1.9-1.72.1-1.3-1.20.5-2.63.53.1
Bone: cortical porosity5.25.713.1-2.3-2.12.5-1.6-1.71.1-2.83.62.9
Bone: cortical thickness0.81.32.81.21.6-0.91.11.7-1.40.9-0.60.1
Bone: cortical thickness1.82.24.51.62.0-1.41.32.1-1.51.2-1.0-0.0
Bone: cortical tissue density1.01.63.21.21.6-1.11.21.8-1.41.2-1.0-0.2
Condit. Reinf. active minus inactive responses0.30.31.2-0.2-0.20.3-0.1-0.5-0.3-0.61.10.9
Condit. Reinf. active-inactive response ratio0.30.31.2-0.00.30.10.10.3-0.6-0.40.81.1
Condit. Reinf. active responses0.20.30.60.70.6-0.70.70.1-0.80.4-0.1-0.1
Condit. Reinf. inactive responses2.53.24.52.11.8-2.12.01.2-1.72.0-1.8-1.4
Incentive salience index mean0.20.31.7-0.2-0.50.2-0.4-1.30.5-0.20.1-0.4
Condit. Reinf. lever presses0.81.34.70.1-0.5-0.2-0.3-1.61.10.7-1.4-2.2
Condit. Reinf. active minus inactive responses1.11.72.6-1.5-1.21.5-1.1-0.60.7-1.61.61.5
Condit. Reinf. active-inactive response ratio1.93.14.2-2.0-1.92.0-1.7-1.31.5-2.01.81.5
Condit. Reinf. active responses0.30.41.0-0.7-0.60.6-0.4-0.1-0.0-0.81.01.0
Condit. Reinf. inactive responses0.40.61.10.80.9-0.80.81.0-1.10.6-0.40.0
Condit. Reinf. lever presses0.30.41.3-0.3-0.50.40.2-0.1-0.4-0.61.21.0
Condit. Reinf. lever reinforcers received0.50.71.6-0.8-0.80.9-0.5-0.30.1-1.11.31.2
Conditioned reinforcement - actives0.10.40.70.60.5-0.80.70.7-0.70.5-0.60.1
Conditioned reinforcement - inactives0.10.20.50.20.1-0.60.50.3-0.70.10.10.5
Conditioned locomotion0.00.00.1-0.2-0.20.20.2-0.10.10.0-0.20.2
Patch foraging indifference point 0 sec0.30.82.90.30.8-0.60.61.7-1.20.10.11.0
Patch foraging indifference point AUC0.71.63.5-1.1-0.91.6-1.0-1.10.6-1.41.21.9
Delay disc. indifference point, 0s delay0.40.41.2-0.6-0.70.5-0.9-1.10.7-0.40.0-0.4
Delay disc. indifference point, 16s delay0.10.20.70.20.4-0.20.30.3-0.8-0.10.50.2
Delay disc. indifference point, 2s delay2.63.04.2-2.0-1.81.4-2.0-1.91.1-2.01.81.1
Delay disc. indifference point, 24s delay0.91.54.9-1.1-0.71.0-0.8-0.6-0.0-1.32.21.6
Delay disc. indifference point, 4s delay1.41.42.5-1.4-1.01.1-1.5-1.00.4-1.61.31.0
Delay disc. indifference point, 8s delay0.20.30.8-0.4-0.20.7-0.5-0.70.1-0.50.90.2
Indifference point function ln k0.20.61.0-0.9-1.00.6-1.0-0.70.9-0.90.80.2
Indifference point function log k0.20.61.0-0.9-1.00.6-1.0-0.70.9-0.90.80.2
Patch foraging total patch changes 0 sec0.30.93.10.40.9-0.60.71.8-1.30.10.11.0
Patch foraging total patch changes 12 sec0.40.52.00.10.6-0.10.40.9-1.1-0.20.31.4
Patch foraging total patch changes 18 sec1.84.37.32.12.6-2.12.12.7-2.31.9-1.7-0.1
Patch foraging total patch changes 24 sec1.03.45.02.12.2-1.82.22.0-2.21.8-1.2-0.3
Patch foraging total patch changes 6 sec0.50.82.30.61.1-0.50.91.3-1.50.30.00.9
Patch foraging time to switch 0 sec1.24.77.52.12.1-2.51.71.6-1.42.5-2.7-2.5
Patch foraging water rate 0 sec0.10.30.5-0.6-0.30.7-0.5-0.00.5-0.50.70.6
Patch foraging water rate 12 sec0.20.81.21.11.1-0.91.01.1-0.80.8-0.5-0.4
Patch foraging water rate 18 sec0.00.10.30.10.40.00.20.5-0.20.10.20.2
Patch foraging water rate 24 sec0.20.31.20.50.6-0.70.41.1-0.60.3-0.10.1
Patch foraging water rate 6 sec0.20.30.60.60.8-0.50.40.7-0.40.4-0.3-0.0
Seeking ratio, delayed vs. immediate footshock0.71.02.6-0.8-0.41.1-1.00.3-0.0-1.41.21.6
Distance traveled before self-admin0.30.62.40.20.1-0.5-0.10.20.60.6-1.6-1.1
Distance traveled after self-admin0.40.71.3-1.0-0.70.9-1.2-0.00.7-1.00.50.9
Extensor digitorum longus weight0.20.71.8-0.9-1.10.7-0.9-0.91.3-0.50.1-0.5
Bone: elastic displacement0.30.40.80.30.4-0.20.70.5-0.80.00.90.9
Bone: elastic work0.10.10.3-0.20.00.2-0.10.00.0-0.30.50.5
Bone: endosteal estimation4.210.214.8-3.8-3.73.4-3.8-2.93.6-3.32.01.2
Bone: endosteal perimeter2.66.410.0-2.8-2.92.7-3.0-2.93.2-2.31.00.1
Epididymis fat weight5.427.139.35.46.0-5.55.16.3-5.15.2-4.9-2.7
Delta time in closed arm before/after self-admin0.20.10.6-0.2-0.20.3-0.3-0.10.40.1-0.4-0.8
Delta time in open arm before/after self-admin0.30.31.20.30.4-0.60.50.7-0.70.20.31.1
Diff in mean of infusions in LGA sessions1.01.75.91.30.9-0.90.80.1-0.21.4-1.8-2.4
Delay discount exponential model param0.71.02.01.10.7-1.01.11.0-0.21.3-1.4-0.7
Extinction: sum of active levers before priming0.40.61.1-0.6-0.80.8-0.7-1.11.0-0.5-0.3-0.7
Active lever presses in extinction session 60.40.41.00.70.6-0.81.00.5-0.70.7-0.3-0.5
Bone: final force0.30.51.30.40.9-0.50.21.20.00.6-1.1-0.4
Bone: final moment0.20.31.10.30.7-0.40.21.0-0.00.5-0.8-0.3
Food consumed during 24 hour testing period0.30.51.3-0.3-0.30.2-0.8-0.51.10.2-1.0-1.2
Glucose5.68.815.4-3.1-3.63.0-3.0-3.93.6-2.51.90.2
Heart weight2.43.96.5-2.3-1.82.3-1.9-1.20.9-2.32.51.9
Delay discount hyperbolic model param1.01.32.51.30.9-1.01.31.1-0.31.5-1.6-0.9
Intermittent access intake day 1-15 change0.00.10.4-0.1-0.00.6-0.10.40.0-0.30.30.6
Intermittent access intake escalation0.10.41.10.30.50.30.41.0-0.7-0.20.41.0
Intermittent access intake escalation 20.20.31.2-0.4-0.41.1-0.4-0.20.2-0.70.60.5
Intermitt. access day 1 inactive lever presses0.11.32.9-1.1-1.30.6-1.5-1.71.5-0.6-0.3-0.9
Intermitt. access day 15 inactive lever presses0.00.10.3-0.5-0.40.4-0.5-0.20.3-0.40.30.0
Intermitt. access escalation Index0.20.62.00.70.2-0.60.1-0.40.20.7-1.3-1.4
Intermittent access day 1 total infusions0.20.62.00.70.3-1.41.20.3-1.00.7-0.2-0.2
Intermittent access day 15 total infusions0.30.61.50.70.7-0.71.10.9-1.20.40.00.7
Intermittent access terminal intake (last 3 days)0.20.41.20.10.1-0.20.70.5-1.0-0.10.61.1
Intermittent access total infusions0.40.41.10.40.3-0.80.90.5-1.00.20.30.7
Intermittent access day 1 locomotion0.51.01.70.90.8-1.31.20.9-1.11.1-1.0-0.6
Intermittent access day 15 total locomotion0.00.10.3-0.00.20.30.10.5-0.10.1-0.20.3
Intermittent access total locomotion0.30.40.80.50.6-0.40.80.9-0.80.4-0.30.3
Intermittent access standard deviation0.10.31.40.10.6-0.10.31.2-0.70.10.00.9
Left kidney weight0.10.52.5-0.70.10.3-0.71.6-0.3-0.50.20.8
Right kidney weight0.00.32.3-0.50.30.2-0.51.5-0.1-0.0-0.20.2
Cocaine induced anxiety0.10.41.6-0.1-0.20.0-0.5-0.50.60.1-1.0-1.3
Post-drug Anxiety0.20.20.5-0.3-0.30.2-0.5-0.30.5-0.2-0.6-0.7
Baseline Anxiety0.10.10.3-0.3-0.10.5-0.20.10.1-0.30.50.5
Tail length2.714.620.2-4.5-3.94.3-4.0-2.33.3-4.44.03.1
Length with tail2.611.517.9-4.2-3.53.8-4.0-2.13.6-3.62.91.9
Length without tail0.41.95.2-1.6-1.11.0-2.1-0.52.3-0.5-0.7-1.1
Times rat made contact with spout1.31.53.61.31.4-1.01.41.3-1.90.50.41.0
Lifetime Intake0.30.30.90.30.2-0.80.80.4-1.00.20.30.6
Liver weight, left1.83.26.1-2.1-2.11.9-2.4-1.32.5-1.60.5-0.1
Liver weight, right2.95.19.0-2.6-2.72.1-2.8-2.43.0-2.10.90.1
Locomotor activity1.92.94.8-2.0-1.71.8-1.9-0.81.2-2.21.61.8
Locomotor testing distance0.41.01.8-1.3-1.21.0-1.4-0.70.9-1.20.40.7
Locomotor testing rearing0.10.41.1-0.8-0.80.4-0.9-0.31.1-0.5-0.2-0.1
Locomotion in novel chamber0.10.10.20.20.3-0.20.00.4-0.30.1-0.5-0.2
Locomotion in novel chamber post-restriction0.00.10.70.10.4-0.30.10.8-0.30.2-0.30.2
Fecal boli incidents, locomotor time 10.41.02.00.80.5-1.11.10.5-0.41.1-1.4-1.3
Change in fecal boli incidents, locomotor task2.32.44.2-1.7-1.41.9-2.0-1.51.7-1.51.00.8
Time >=10cm from walls, locomotor time 10.81.02.0-0.8-0.70.7-1.3-0.61.4-0.2-1.0-1.4
Bouts of movement, locomotor time 10.00.10.30.30.2-0.20.1-0.2-0.20.10.10.5
Total resting periods, locomotor time 10.10.10.30.0-0.00.1-0.1-0.30.0-0.00.30.6
Rest time, locomotor task time 10.30.40.9-0.8-1.00.5-0.6-0.80.7-0.70.40.1
Distance moved, locomotor task time 10.00.00.10.00.3-0.1-0.10.3-0.2-0.00.20.4
Vertical activity count, locomotor time 10.10.41.10.51.1-0.80.21.0-0.70.5-0.10.2
Time >=10cm from walls, locomotor time 20.51.52.7-1.6-1.21.5-1.6-1.01.4-1.10.70.1
Bouts of movement, locomotor time 20.30.91.9-1.0-0.81.0-1.0-0.60.2-1.41.31.0
Total resting periods, locomotor time 20.52.03.4-1.4-1.31.4-1.5-1.10.7-1.91.81.3
Rest time, locomotor task time 20.61.02.2-0.6-1.00.5-1.1-1.31.5-0.2-0.6-1.4
Distance moved, locomotor task time 20.50.61.10.61.1-0.61.01.1-0.90.80.10.3
Vertical activity count, locomotor time 20.10.20.50.20.7-0.40.40.7-0.60.40.20.2
Light reinforcement 10.21.12.91.01.1-0.70.51.1-0.21.2-1.7-1.3
Light reinforcement 20.20.52.20.30.3-0.2-0.10.30.50.7-1.5-1.3
Bone: marrow area4.110.014.6-3.8-3.63.4-3.7-2.83.6-3.32.01.2
Bone: maximum diameter1.93.85.7-2.1-2.22.1-2.3-2.42.3-1.80.90.1
Bone: maximum force0.10.20.50.10.4-0.2-0.10.70.10.3-0.7-0.4
Bone: maximum moment0.00.10.2-0.10.1-0.1-0.10.50.20.1-0.4-0.3
Mean time between licks in bursts0.53.25.5-1.8-2.31.9-1.7-2.32.3-1.60.90.2
Mean num. licks in bursts1.23.36.91.82.1-1.82.12.3-2.61.3-0.20.5
Cd content in liver2.83.14.61.81.6-2.11.71.3-1.12.1-1.9-1.9
Co content in liver0.70.81.70.81.1-1.00.81.3-0.91.0-0.8-0.5
Cu content in liver1.82.14.51.71.8-1.61.61.5-2.11.0-0.70.2
Fe content in liver0.91.22.11.01.2-1.11.11.4-1.11.1-0.9-0.4
K content in liver0.30.30.60.60.3-0.60.50.0-0.20.6-0.7-0.8
Mg content in liver1.01.12.7-0.8-1.20.9-1.1-1.61.6-0.5-0.2-0.8
Mn content in liver2.52.86.7-1.4-1.81.5-1.9-2.42.6-0.9-0.2-1.1
Na content in liver0.20.20.70.40.5-0.10.20.4-0.7-0.10.20.8
Rb content in liver0.60.71.90.70.4-0.80.70.30.01.1-1.2-1.4
Se content in liver4.85.67.7-2.3-2.62.6-2.6-2.82.6-2.51.81.1
Sr content in liver0.30.30.6-0.7-0.60.5-0.4-0.60.8-0.30.5-0.1
Zn content in liver0.10.20.5-0.3-0.50.2-0.3-0.50.7-0.1-0.1-0.5
Bone: minimum diameter2.24.27.8-2.2-2.32.3-2.5-2.22.8-1.70.7-0.0
Time in familiar zone, hab. session 12.73.05.32.01.9-1.82.31.8-2.31.4-0.40.1
Time in novel zone, hab. session 12.32.64.3-2.0-1.81.8-2.1-1.51.8-1.50.90.4
Total zone transitions, hab. session 10.10.10.30.30.1-0.20.1-0.1-0.10.2-0.5-0.4
Total locomotion distance, hab. session 10.30.41.00.60.3-0.60.40.1-0.10.7-1.0-1.0
Locomotion velocity, hab. session 10.10.10.30.30.1-0.20.2-0.0-0.00.3-0.6-0.5
Time in familiar zone, hab. session 20.70.81.71.01.2-0.80.81.3-0.90.6-0.70.2
Time in novel zone, hab. session 20.40.51.2-0.8-0.70.6-0.4-0.60.3-0.61.10.5
Total zone transitions, hab. session 20.70.92.70.90.8-0.90.50.5-0.31.1-1.6-1.2
Total locomotion distance, hab. session 21.82.46.01.61.2-1.51.00.6-0.41.8-2.4-2.1
Locomotion velocity, hab. session 21.52.05.31.41.0-1.30.80.3-0.21.6-2.3-2.1
Novel to familiar place preference ratio0.10.10.4-0.2-0.20.2-0.0-0.3-0.0-0.30.60.4
Novelty place preference0.30.30.9-0.5-0.50.6-0.3-0.50.2-0.61.00.7
Time in novel zone, NPP test0.50.61.5-0.7-0.70.8-0.4-0.60.4-0.91.21.0
Total zone transitions, NPP test0.71.12.21.10.6-1.11.00.2-0.51.3-1.3-1.5
Total locomotion distance, NPP test2.33.26.41.81.3-2.01.60.6-0.82.2-2.3-2.5
Locomotion velocity, NPP test3.04.38.72.11.5-2.31.80.7-0.92.6-2.7-2.9
Intraocular pressure1.22.02.91.51.5-1.51.71.5-1.41.5-1.1-0.6
Delta distance traveled before/after self-admin2.62.86.3-1.7-1.21.6-1.3-0.50.2-2.12.52.5
Delta ambulatory time before/after self-admin1.73.06.3-1.7-1.31.8-1.5-0.70.5-2.12.52.4
Parametrial fat weight1.94.57.62.12.4-2.21.72.1-1.52.4-2.8-1.8
Pavlov. Cond. lever latency2.12.77.11.52.2-1.61.32.7-1.61.3-1.3-0.1
Pavlov. Cond. magazine entry latency2.83.65.0-1.7-2.02.1-1.6-2.21.6-2.12.11.5
Pavlov. Cond. change in total contacts2.32.43.1-1.5-1.71.7-1.4-1.81.3-1.71.61.2
Pavlov. Cond. index score2.83.57.4-1.7-2.22.0-1.7-2.72.0-1.81.60.6
Pavlov. Cond. latency score3.03.87.9-1.8-2.32.0-1.7-2.82.0-1.81.60.6
Pavlov. Cond. lever contacts1.82.16.2-1.3-1.91.3-1.3-2.51.7-0.90.6-0.5
Pavlov. Cond. magazine entry number1.82.33.11.41.6-1.61.21.8-1.31.6-1.6-1.1
Pavlov. Cond. intertrial magazine entries3.74.56.02.22.2-2.52.22.2-2.22.2-1.8-1.3
Pavlov. Cond. lever-magazine prob. diff.2.53.16.8-1.6-2.11.8-1.5-2.61.9-1.61.50.5
Pavlov. Cond. response bias2.02.45.1-1.4-1.91.6-1.4-2.31.6-1.51.30.5
Pavlov. Cond. lever latency0.30.51.2-0.4-0.50.4-0.8-0.81.1-0.1-0.7-0.9
Pavlov. Cond. magazine entry latency0.20.30.5-0.5-0.70.5-0.2-0.60.7-0.40.60.2
Pavlov. Cond. change in total contacts0.30.62.1-0.4-0.30.50.10.2-0.5-0.71.41.4
Pavlov. Cond. index score0.20.31.2-0.3-0.40.40.1-0.1-0.1-0.51.10.9
Pavlov. Cond. latency score0.20.31.1-0.3-0.30.40.1-0.0-0.2-0.51.00.9
Pavlov. Cond. lever contacts0.30.41.00.40.4-0.30.70.7-1.00.10.60.8
Pavlov. Cond. magazine entry number0.00.00.1-0.10.10.1-0.30.0-0.2-0.2-0.10.1
Pavlov. Cond. intertrial magazine entries0.40.91.5-0.9-1.01.0-1.1-1.20.8-1.00.40.4
Pavlov. Cond. lever-magazine prob. diff.0.10.20.9-0.2-0.30.30.2-0.1-0.1-0.40.90.8
Pavlov. Cond. response bias0.10.10.50.1-0.00.00.40.0-0.3-0.10.70.6
Time in closed arm before self-admin0.30.40.7-0.8-0.80.8-0.7-0.60.6-0.70.50.1
Time in closed arm after self-admin0.10.10.7-0.1-0.20.0-0.1-0.10.20.0-0.4-0.9
Time in open arm before self-admin0.40.51.4-0.6-0.70.6-0.4-0.70.2-0.91.20.7
Time in open arm after self-admin0.50.52.0-0.5-0.50.3-0.1-0.0-0.2-0.81.21.4
Bone: periosteal estimation2.35.48.0-2.8-2.52.6-2.8-1.92.6-2.51.41.0
Bone: periosteal perimeter1.83.55.0-2.1-2.02.2-2.2-2.02.1-1.91.10.6
Bone: post-yield work0.71.32.4-1.2-1.51.0-1.2-1.31.6-0.6-0.1-0.9
Progressive ratio test 1 active lever presses0.10.10.80.0-0.1-0.90.30.0-0.40.2-0.0-0.1
Progressive ratio test 1 breakpoint0.10.10.7-0.0-0.2-0.80.30.0-0.40.10.0-0.0
Progressive ratio test 1 inactive lever presses0.82.02.91.41.3-1.71.31.2-1.31.5-1.5-1.3
Progressive ratio test 2 active lever presses0.40.50.90.90.7-0.81.00.6-0.90.7-0.7-0.0
Progressive ratio test 2 breakpoint0.50.61.10.90.7-0.81.00.7-1.00.7-0.60.1
Progressive ratio test 2 inactive lever presses0.00.10.5-0.3-0.70.1-0.0-0.60.2-0.10.1-0.4
Incentive Sensitization - Responses0.00.10.20.40.20.10.30.2-0.30.1-0.30.3
Incentive Sensitization - Breakpoint0.10.20.50.70.5-0.20.60.4-0.50.4-0.60.2
Sum of active levers in priming session hrs 5-60.60.61.3-0.8-0.90.6-0.5-0.70.5-0.81.20.7
Progressive ratio0.10.41.6-0.10.5-0.1-0.31.3-0.6-0.30.10.8
Food seeking constrained by brief footshock0.10.10.30.20.3-0.20.40.4-0.50.00.60.5
Seeking ratio, punishment vs. effort0.20.41.7-0.4-0.80.7-0.1-1.30.5-0.30.70.1
Retroperitoneal fat weight0.52.34.71.51.4-1.51.21.1-0.71.7-2.2-1.8
Reaction time number correct0.31.13.00.81.2-1.01.11.7-1.40.80.20.2
Reaction time mean minus median0.10.51.2-0.6-1.10.7-0.6-1.01.0-0.50.3-0.2
Reaction time mean minus median AUC0.10.30.8-0.3-0.90.3-0.2-0.90.9-0.10.3-0.6
Reaction time num false alarms0.61.01.7-0.9-1.01.3-1.1-0.91.3-1.10.60.4
Reaction time num false alarms AUC0.92.03.2-1.4-1.41.8-1.6-1.21.4-1.71.21.1
Reaction time trials correct on left0.31.13.00.81.2-1.01.11.7-1.40.80.20.2
Reaction time trials on left0.31.02.80.81.1-0.91.01.7-1.40.70.20.2
Reaction time mean0.40.92.4-0.5-1.00.3-0.7-1.41.50.1-0.5-1.3
Reaction time mean AUC0.30.82.1-0.4-1.00.2-0.6-1.21.40.1-0.5-1.3
Median of all reaction times0.50.82.0-0.3-0.80.1-0.6-1.21.40.3-0.7-1.4
Reaction time omissions0.40.71.6-0.5-0.90.3-0.7-1.11.3-0.1-0.6-1.1
Reaction time false alarm rate2.73.85.0-1.9-2.12.2-2.2-2.22.1-2.11.31.0
Reaction time premature initiation rate0.00.00.1-0.3-0.20.1-0.10.00.00.1-0.1-0.0
Reaction time premature initiations0.10.21.00.10.5-0.30.41.0-0.80.40.00.1
Std. dev. reaction times0.62.13.5-1.4-1.91.5-1.4-1.81.8-1.20.90.1
Reaction time trials completed0.31.02.80.81.1-0.91.01.7-1.40.70.20.2
Reaction time trials AUC0.31.12.90.91.2-1.01.11.7-1.30.80.00.0
Run reversals in cocaine runway, females0.70.81.20.90.9-0.91.10.9-0.91.0-0.7-0.6
Run reversals in cocaine runway, males0.30.30.7-0.6-0.80.5-0.6-0.80.7-0.50.3-0.0
Latency to leave start box in cocaine runway0.40.61.5-0.3-0.60.1-0.6-1.21.0-0.1-0.6-1.1
Latency to leave start box in cocaine runway, F0.30.41.50.0-0.3-0.3-0.3-0.90.50.2-0.9-1.2
Latency to leave start box in cocaine runway, M0.20.20.5-0.3-0.40.4-0.6-0.70.7-0.20.1-0.3
Std. dev. time between licks in bursts3.26.09.1-2.6-3.02.7-2.6-2.93.0-2.21.40.5
Total sessions with >9 infusions0.30.31.4-0.2-0.2-0.30.20.1-0.6-0.40.91.2
Short access day 1 total inactive lever presses0.30.71.7-1.0-1.20.0-0.6-1.30.7-0.70.80.2
Short access day 10 total inactive lever presses0.10.51.70.60.4-0.7-0.1-0.00.20.7-1.2-1.3
Short access day 1 total infusions0.10.20.7-0.4-0.5-0.20.1-0.6-0.1-0.30.80.6
Short access day 10 total infusions0.40.72.00.70.6-1.41.00.5-1.20.6-0.20.3
Short access total infusions0.10.20.70.10.0-0.80.60.0-0.70.20.40.4
Short access day 1 locomotion0.10.10.50.40.1-0.70.2-0.2-0.10.4-0.6-0.3
Short access day 10 total locomotion0.62.54.3-2.0-1.71.6-2.1-1.01.4-1.81.01.3
Short access total locomotion0.30.40.7-0.8-0.80.5-0.8-0.60.7-0.50.10.1
One hour access (0.3 mA shock)0.50.51.11.00.7-0.80.70.1-0.70.8-1.0-0.3
Compulsive drug intake1.01.54.6-0.1-0.50.5-1.1-1.31.60.2-1.8-2.1
One hour access (shock baseline)0.61.53.11.11.1-1.21.61.3-1.80.80.31.2
Social response proportion1.01.22.2-1.5-1.30.8-1.5-1.11.1-1.20.60.3
Social responses1.01.32.2-1.4-1.21.1-1.5-1.00.8-1.50.80.9
Social time1.32.04.6-1.1-1.51.0-1.8-1.92.1-0.9-0.6-0.8
Soleus weight3.510.218.9-3.4-3.73.5-3.7-3.74.3-2.51.2-0.4
Bone: stiffness0.50.92.00.91.1-0.90.51.1-0.40.9-1.4-0.8
Tibialis anterior weight0.41.42.21.21.3-1.41.01.5-1.41.0-1.0-0.3
Time to tail flick, vehicle, before self-admin1.01.33.41.31.3-0.70.50.7-0.21.2-1.8-1.4
Time to tail flick, vehicle, after self-admin0.20.30.9-0.5-0.60.5-0.5-0.90.9-0.50.10.4
Time to tail flick, test, before self-admin0.10.20.50.40.5-0.20.30.4-0.7-0.1-0.10.5
Time to tail flick, test, after self-admin0.30.30.80.70.4-0.90.90.5-0.40.30.10.1
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.0-0.2-0.40.5-0.4-0.3-0.10.80.6
Delta time to tail flick, test, before/after SA0.91.11.81.20.8-1.31.20.8-0.31.3-1.0-1.1
Tibia length2.05.610.7-2.9-2.62.6-2.9-1.83.3-2.21.00.5
Ambulatory time before self-admin0.10.31.40.40.2-0.70.30.30.10.5-1.2-0.7
Ambulatory time after self-admin0.60.91.5-1.1-0.91.0-1.1-0.20.6-1.20.81.1
Bone: tissue strength0.20.20.30.20.2-0.60.40.3-0.30.5-0.4-0.6
Total heroin consumption0.10.10.3-0.4-0.40.5-0.5-0.30.3-0.5-0.1-0.1
Bone: trabecular number3.36.28.62.92.4-2.92.91.9-2.22.8-2.3-1.9
Bone: trabecular spacing3.45.06.8-2.6-2.02.6-2.6-1.61.9-2.42.31.8
Bone: trabecular thickness3.34.66.02.42.0-2.52.31.7-1.72.4-2.3-1.8
Bone: trabecular tissue density1.12.04.9-1.3-1.21.4-0.8-0.60.5-1.62.22.0
Water consumed over 24 hours0.30.50.8-0.7-0.70.7-0.9-0.90.9-0.60.30.0
Number of responses in last shaping day4.35.67.3-2.7-2.62.3-2.5-2.32.1-2.62.31.8