Six5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Six5	0.15	0.14	8.0e-07	0.06	0.05	0.05	0.06	6.6e-07	1.2e-06	1.1e-06	7.3e-07
2	LHb	gene expression	Six5	0.21	0.18	6.4e-04	0.07	0.15	0.1	0.09	8.3e-03	2.1e-04	2.3e-03	3.2e-03
3	Brain	gene expression	Six5	0.04	0.04	1.4e-03	0.02	0.02	0.02	0.02	5.6e-03	3.7e-03	5.0e-03	6.2e-03
4	Liver	gene expression	Six5	0.18	0.13	5.1e-11	0.09	0.09	0.09	0.09	2.8e-10	7.6e-10	7.5e-10	5.4e-10
5	NAcc	gene expression	Six5	0.2	0.13	1.2e-07	0.04	0.04	0.04	0.04	8.2e-07	1.9e-07	1.4e-06	9.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.0	0.0	0.1	0.2	-0.0	0.0	-0.2	0.2
Area under the delay curve	1.2	1.8	2.6	-1.0	1.3	1.3	-1.5	1.6
BMI with tail	0.6	2.1	3.9	2.0	-1.5	-1.5	1.3	-0.6
BMI without tail	0.5	2.6	5.6	2.4	-1.6	-1.6	1.3	-0.5
Body weight	1.3	5.5	9.9	3.1	-2.4	-2.4	2.2	-1.2
Weight adjusted by age	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.0	0.2
Bone surface	0.2	0.4	0.8	0.9	-0.7	-0.6	0.6	-0.3
Bone volume	0.1	0.3	0.5	0.7	-0.6	-0.5	0.4	-0.3
Breakpoint value in progressive ratio session	1.5	2.7	3.8	-2.0	1.7	1.7	-1.6	1.3
Number of licking bursts	1.3	4.1	4.4	1.9	-2.0	-2.1	2.1	-2.0
Context. condit. distance diff. score	0.1	0.1	0.4	0.1	-0.3	-0.3	0.3	-0.6
Locomotion velocity, session 1	0.1	0.1	0.2	-0.5	0.3	0.3	-0.3	-0.1
Locomotion distance, session 1	0.0	0.0	0.2	-0.2	-0.0	-0.0	0.1	-0.4
Locomotion velocity, session 2	1.4	1.6	2.2	1.5	-1.3	-1.3	1.2	-1.0
Locomotion distance, session 2	0.2	0.3	0.4	0.6	-0.6	-0.5	0.5	-0.5
Locomotion velocity, session 3	0.2	0.3	0.5	0.7	-0.5	-0.5	0.5	-0.3
Locomotion distance, session 3	0.7	0.8	1.1	-0.7	0.9	0.9	-0.9	1.1
Stereotopy head waving bouts, day 3	1.0	1.2	1.3	1.0	-1.1	-1.1	1.1	-1.1
Stereotopy head waving duration, day 3	1.0	1.3	1.8	0.8	-1.1	-1.1	1.2	-1.4
Locomotion velocity, session 7	0.2	0.2	0.3	-0.5	0.5	0.5	-0.4	0.3
Locomotion distance, session 7	0.0	0.0	0.1	0.3	-0.1	-0.1	0.2	0.0
Stereotopy head waving bouts, day 7	1.0	1.1	1.6	0.8	-1.1	-1.1	1.0	-1.3
Stereotopy head waving duration, day 7	0.8	1.0	1.2	0.8	-1.0	-1.0	0.9	-1.1
Locomotion velocity, session 8	0.0	0.0	0.0	-0.0	0.1	0.1	-0.0	-0.1
Locomotion distance, session 8	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.1
Degree of sensitization distance	0.5	0.6	0.7	0.7	-0.8	-0.8	0.8	-0.8
Degree of sensitization stereotypy	1.0	1.1	1.4	0.9	-1.1	-1.1	1.0	-1.2
Conditioned locomotion	0.0	0.1	0.1	-0.3	0.2	0.2	-0.2	0.2
Cocaine response after cond. corrected	0.4	0.6	0.9	0.6	-0.8	-0.8	0.8	-0.9
Cocaine response after cond. not corrected	1.1	1.5	1.7	1.1	-1.3	-1.2	1.3	-1.3
Cocaine response before conditioning	1.5	1.8	2.0	1.4	-1.4	-1.4	1.3	-1.2
Saline control response	2.0	2.7	3.0	1.5	-1.7	-1.7	1.7	-1.6
Bone: connectivity density	0.1	0.1	0.3	0.1	0.2	0.2	-0.4	0.5
Bone: cortical apparent density	0.1	0.1	0.3	-0.3	0.3	0.3	-0.5	0.4
Bone: cortical area	1.5	2.5	2.8	1.7	-1.6	-1.6	1.6	-1.4
Bone: cortical porosity	0.1	0.1	0.1	-0.3	0.4	0.3	-0.3	0.3
Bone: cortical porosity	0.0	0.0	0.0	0.2	-0.0	-0.1	0.1	0.0
Bone: cortical thickness	0.6	1.0	1.0	1.0	-1.0	-1.0	1.0	-1.0
Bone: cortical thickness	1.4	1.7	1.8	1.3	-1.3	-1.3	1.2	-1.3
Bone: cortical tissue density	0.1	0.2	0.4	-0.4	0.4	0.4	-0.6	0.5
Condit. Reinf. active minus inactive responses	0.4	0.4	0.8	0.9	-0.7	-0.7	0.5	-0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	0.8	-0.6	-0.6	0.3	-0.2
Condit. Reinf. active responses	0.2	0.2	0.5	0.7	-0.5	-0.5	0.3	-0.2
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.4	0.3	0.3	-0.3	0.2
Incentive salience index mean	0.3	0.3	0.8	0.9	-0.6	-0.6	0.4	-0.1
Condit. Reinf. lever presses	0.1	0.1	0.3	0.6	-0.2	-0.2	0.0	0.3
Condit. Reinf. active minus inactive responses	0.0	0.1	0.2	0.1	-0.3	-0.2	0.2	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.4	0.8	0.3	-0.6	-0.5	0.6	-0.9
Condit. Reinf. active responses	0.1	0.1	0.2	-0.4	0.3	0.3	-0.4	0.3
Condit. Reinf. inactive responses	0.6	0.9	1.0	-0.9	0.9	0.9	-1.0	1.0
Condit. Reinf. lever presses	0.1	0.1	0.2	0.4	-0.4	-0.4	0.4	-0.3
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	-0.4	0.4	0.4	-0.4	0.3
Conditioned reinforcement - actives	0.6	2.3	3.7	1.9	-1.6	-1.5	1.4	-1.0
Conditioned reinforcement - inactives	0.4	1.0	2.6	1.6	-0.9	-0.9	0.8	-0.0
Conditioned locomotion	1.9	2.8	3.6	1.4	-1.7	-1.7	1.7	-1.9
Patch foraging indifference point 0 sec	0.3	0.8	1.6	0.4	-0.8	-0.8	0.9	-1.3
Patch foraging indifference point AUC	2.0	4.7	6.4	2.5	-2.2	-2.2	2.2	-1.6
Delay disc. indifference point, 0s delay	1.1	1.3	2.3	-0.6	1.1	1.1	-1.2	1.5
Delay disc. indifference point, 16s delay	0.9	1.2	2.0	-0.7	1.0	1.0	-1.2	1.4
Delay disc. indifference point, 2s delay	3.2	3.6	5.4	-1.2	1.9	1.8	-2.0	2.3
Delay disc. indifference point, 24s delay	0.0	0.0	0.2	-0.0	-0.1	-0.1	0.0	-0.4
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	0.2	-0.0	-0.0	-0.1	0.1
Delay disc. indifference point, 8s delay	1.1	1.8	1.9	-1.3	1.4	1.4	-1.3	1.3
Indifference point function ln k	0.6	1.8	3.3	-1.8	1.3	1.4	-1.3	0.4
Indifference point function log k	0.6	1.8	3.3	-1.8	1.3	1.4	-1.3	0.4
Patch foraging total patch changes 0 sec	0.4	1.2	2.3	0.6	-1.0	-1.0	1.1	-1.5
Patch foraging total patch changes 12 sec	1.6	2.1	3.2	1.8	-1.5	-1.5	1.4	-0.9
Patch foraging total patch changes 18 sec	1.3	3.0	3.4	1.6	-1.7	-1.7	1.8	-1.9
Patch foraging total patch changes 24 sec	0.2	0.6	1.2	1.1	-0.8	-0.8	0.8	-0.4
Patch foraging total patch changes 6 sec	2.2	3.7	3.9	1.8	-1.9	-1.9	2.0	-2.0
Patch foraging time to switch 0 sec	1.2	4.7	5.6	-1.8	2.2	2.2	-2.3	2.4
Patch foraging water rate 0 sec	1.5	5.6	6.3	2.1	-2.4	-2.4	2.4	-2.5
Patch foraging water rate 12 sec	0.1	0.2	0.3	0.4	-0.5	-0.4	0.4	-0.5
Patch foraging water rate 18 sec	0.1	0.2	0.2	0.4	-0.4	-0.4	0.4	-0.4
Patch foraging water rate 24 sec	0.5	0.7	1.4	0.4	-0.8	-0.8	0.8	-1.2
Patch foraging water rate 6 sec	0.6	0.8	0.9	0.9	-1.0	-0.9	0.9	-0.8
Seeking ratio, delayed vs. immediate footshock	1.6	2.4	2.9	-1.7	1.5	1.5	-1.5	1.3
Distance traveled before self-admin	0.0	0.1	0.2	0.3	-0.3	-0.2	0.3	-0.4
Distance traveled after self-admin	0.1	0.2	0.4	-0.6	0.5	0.5	-0.4	0.3
Extensor digitorum longus weight	1.9	7.6	9.7	3.1	-2.7	-2.7	2.8	-2.4
Bone: elastic displacement	0.8	1.0	1.2	-0.9	1.0	1.0	-1.1	1.1
Bone: elastic work	0.1	0.1	0.3	0.5	-0.2	-0.2	0.1	0.1
Bone: endosteal estimation	0.0	0.1	0.3	0.2	0.2	0.2	-0.2	0.6
Bone: endosteal perimeter	0.0	0.0	0.1	0.3	-0.0	-0.0	0.0	0.2
Epididymis fat weight	0.1	0.7	1.3	-0.5	0.8	0.8	-0.9	1.2
Delta time in closed arm before/after self-admin	0.3	0.2	0.7	-0.8	0.4	0.4	-0.4	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.5	0.4	0.0	0.0	-0.1	0.7
Diff in mean of infusions in LGA sessions	1.0	1.8	2.8	-1.7	1.3	1.3	-1.2	1.0
Delay discount exponential model param	1.0	1.3	1.7	0.9	-1.1	-1.1	1.3	-1.3
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.1	0.2	0.2	-0.1	0.2
Active lever presses in extinction session 6	0.2	0.2	0.4	0.6	-0.3	-0.3	0.3	0.0
Bone: final force	0.4	0.7	1.2	1.1	-0.8	-0.8	0.8	-0.6
Bone: final moment	0.6	1.0	1.7	1.3	-1.0	-1.0	1.0	-0.7
Food consumed during 24 hour testing period	3.5	7.1	7.6	-2.7	2.7	2.7	-2.7	2.5
Glucose	0.3	0.5	1.1	-1.0	0.7	0.6	-0.6	0.2
Heart weight	2.0	3.3	3.9	1.5	-1.8	-1.8	1.9	-2.0
Delay discount hyperbolic model param	0.9	1.2	1.6	0.8	-1.0	-1.0	1.2	-1.3
Intermittent access intake day 1-15 change	0.0	0.2	0.2	0.4	-0.4	-0.4	0.4	-0.3
Intermittent access intake escalation	0.0	0.2	0.4	0.6	-0.5	-0.5	0.5	-0.3
Intermittent access intake escalation 2	0.0	0.1	0.2	-0.3	0.0	0.0	0.1	-0.4
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	0.5	-0.1	-0.1	0.1	0.3
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	0.2	-0.1	-0.1	0.0	0.2
Intermitt. access escalation Index	0.1	0.3	0.4	-0.6	0.5	0.5	-0.6	0.4
Intermittent access day 1 total infusions	0.9	2.7	4.6	2.1	-1.7	-1.7	1.5	-0.9
Intermittent access day 15 total infusions	0.5	1.2	2.0	1.4	-1.1	-1.1	1.1	-0.6
Intermittent access terminal intake (last 3 days)	0.9	1.5	1.8	1.3	-1.3	-1.3	1.2	-1.0
Intermittent access total infusions	2.5	3.0	3.7	1.9	-1.8	-1.8	1.7	-1.4
Intermittent access day 1 locomotion	0.3	0.5	1.1	1.0	-0.7	-0.7	0.6	-0.2
Intermittent access day 15 total locomotion	0.1	0.3	0.5	0.7	-0.5	-0.5	0.5	-0.3
Intermittent access total locomotion	1.7	2.0	2.7	1.6	-1.5	-1.4	1.4	-1.1
Intermittent access standard deviation	0.0	0.2	0.3	-0.5	0.5	0.5	-0.4	0.3
Left kidney weight	3.1	24.8	29.2	5.4	-5.1	-5.1	4.9	-4.3
Right kidney weight	3.3	22.7	25.8	5.1	-4.9	-4.8	4.7	-4.2
Cocaine induced anxiety	0.1	0.2	0.6	-0.1	0.4	0.4	-0.5	0.8
Post-drug Anxiety	0.0	0.0	0.0	-0.2	0.1	0.1	-0.1	0.2
Baseline Anxiety	0.2	0.4	1.0	-1.0	0.2	0.2	0.1	-0.9
Tail length	0.3	1.8	3.9	2.0	-1.3	-1.3	1.1	-0.6
Length with tail	0.4	1.7	3.5	1.9	-1.3	-1.3	1.1	-0.7
Length without tail	0.2	1.0	1.4	1.2	-1.1	-1.0	0.9	-0.8
Times rat made contact with spout	0.1	0.1	0.2	-0.4	0.2	0.2	-0.2	-0.2
Lifetime Intake	2.5	3.1	4.4	2.1	-1.8	-1.8	1.7	-1.3
Liver weight, left	2.1	3.7	4.6	2.2	-2.0	-2.0	1.8	-1.6
Liver weight, right	1.4	2.4	4.3	2.1	-1.6	-1.6	1.3	-0.9
Locomotor activity	2.2	3.5	4.1	1.6	-1.8	-1.8	2.0	-2.0
Locomotor testing distance	0.9	2.2	2.4	1.5	-1.5	-1.5	1.6	-1.3
Locomotor testing rearing	2.4	8.8	10.1	3.2	-3.0	-3.0	3.0	-2.6
Locomotion in novel chamber	0.3	0.4	1.3	-1.2	0.6	0.6	-0.4	-0.1
Locomotion in novel chamber post-restriction	0.4	1.3	1.5	-1.1	1.2	1.2	-1.1	1.1
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	0.4	-0.3	-0.3	0.3	-0.0
Change in fecal boli incidents, locomotor task	0.6	0.7	0.9	-0.5	0.8	0.8	-0.9	1.0
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.1	0.0	0.1	-0.1	0.1
Bouts of movement, locomotor time 1	2.1	2.7	2.9	-1.7	1.7	1.7	-1.7	1.5
Total resting periods, locomotor time 1	3.0	3.4	3.7	-1.8	1.9	1.9	-1.9	1.8
Rest time, locomotor task time 1	0.1	0.2	0.2	-0.4	0.5	0.5	-0.4	0.5
Distance moved, locomotor task time 1	0.2	0.5	0.6	0.7	-0.8	-0.8	0.7	-0.7
Vertical activity count, locomotor time 1	0.0	0.1	0.2	0.4	-0.1	-0.1	0.0	0.4
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	0.1	0.2	0.2	-0.2	0.3
Bouts of movement, locomotor time 2	2.3	7.6	9.7	-3.1	2.8	2.8	-2.8	2.2
Total resting periods, locomotor time 2	1.7	6.9	9.6	-3.1	2.7	2.7	-2.7	1.9
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.6	0.3	0.3	-0.2	-0.1
Distance moved, locomotor task time 2	0.7	1.0	1.4	1.2	-1.0	-1.0	0.9	-0.8
Vertical activity count, locomotor time 2	0.1	0.2	0.6	0.3	0.1	0.1	-0.2	0.8
Light reinforcement 1	0.0	0.1	0.2	0.4	-0.4	-0.3	0.4	-0.2
Light reinforcement 2	0.2	0.4	1.2	1.1	-0.4	-0.4	0.4	0.4
Bone: marrow area	0.0	0.1	0.3	0.2	0.1	0.1	-0.1	0.5
Bone: maximum diameter	2.1	4.2	4.7	2.2	-2.1	-2.1	2.1	-1.8
Bone: maximum force	0.2	0.3	0.7	0.8	-0.6	-0.6	0.5	-0.3
Bone: maximum moment	0.3	0.5	1.0	1.0	-0.7	-0.7	0.7	-0.4
Mean time between licks in bursts	0.0	0.1	0.2	-0.1	0.2	0.2	-0.3	0.4
Mean num. licks in bursts	1.7	4.5	5.0	-2.2	2.1	2.2	-2.2	1.8
Cd content in liver	0.2	0.2	0.6	-0.7	0.3	0.4	-0.3	-0.1
Co content in liver	1.3	1.5	1.9	-1.4	1.2	1.2	-1.2	1.1
Cu content in liver	0.4	0.4	0.6	0.7	-0.7	-0.7	0.7	-0.5
Fe content in liver	4.9	6.1	7.5	2.1	-2.5	-2.5	2.5	-2.7
K content in liver	0.3	0.3	0.9	0.9	-0.5	-0.5	0.5	0.0
Mg content in liver	0.6	0.7	1.3	1.1	-0.8	-0.9	0.8	-0.4
Mn content in liver	1.0	1.1	1.9	1.4	-1.1	-1.1	1.0	-0.7
Na content in liver	0.2	0.3	0.6	0.2	-0.4	-0.4	0.6	-0.8
Rb content in liver	0.1	0.1	0.1	0.3	-0.3	-0.2	0.3	-0.3
Se content in liver	4.1	4.8	5.5	2.3	-2.2	-2.3	2.2	-1.9
Sr content in liver	0.0	0.0	0.0	0.2	-0.2	-0.2	0.2	-0.2
Zn content in liver	0.9	1.1	1.9	1.4	-1.0	-1.0	1.0	-0.6
Bone: minimum diameter	0.2	0.4	0.7	0.8	-0.6	-0.6	0.6	-0.4
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.2	-0.4	-0.4	0.5	-0.6
Time in novel zone, hab. session 1	0.6	0.6	0.8	0.9	-0.8	-0.8	0.7	-0.6
Total zone transitions, hab. session 1	0.1	0.2	0.4	0.3	-0.4	-0.4	0.4	-0.6
Total locomotion distance, hab. session 1	0.4	0.5	0.6	-0.7	0.7	0.7	-0.8	0.7
Locomotion velocity, hab. session 1	1.2	1.7	1.9	-1.2	1.3	1.3	-1.4	1.3
Time in familiar zone, hab. session 2	0.3	0.3	0.4	0.6	-0.6	-0.6	0.5	-0.5
Time in novel zone, hab. session 2	0.1	0.1	0.4	-0.6	0.3	0.3	-0.2	-0.1
Total zone transitions, hab. session 2	0.5	0.7	0.9	0.6	-0.8	-0.8	0.8	-0.9
Total locomotion distance, hab. session 2	0.5	0.7	0.7	-0.8	0.8	0.8	-0.8	0.8
Locomotion velocity, hab. session 2	0.3	0.4	0.5	-0.6	0.6	0.6	-0.7	0.7
Novel to familiar place preference ratio	0.4	0.5	0.5	0.6	-0.7	-0.6	0.7	-0.7
Novelty place preference	0.3	0.4	0.5	0.6	-0.6	-0.6	0.7	-0.7
Time in novel zone, NPP test	0.5	0.6	0.8	0.6	-0.7	-0.7	0.8	-0.9
Total zone transitions, NPP test	0.1	0.2	0.3	0.3	-0.4	-0.4	0.4	-0.5
Total locomotion distance, NPP test	0.1	0.1	0.4	0.0	-0.3	-0.3	0.4	-0.6
Locomotion velocity, NPP test	0.1	0.1	0.2	0.1	-0.2	-0.2	0.3	-0.5
Intraocular pressure	0.1	0.1	0.4	-0.6	0.2	0.2	-0.1	-0.5
Delta distance traveled before/after self-admin	1.7	1.9	3.6	-0.9	1.3	1.3	-1.3	1.9
Delta ambulatory time before/after self-admin	0.3	0.5	0.9	-0.4	0.6	0.6	-0.6	1.0
Parametrial fat weight	0.1	0.2	0.3	0.5	-0.4	-0.4	0.4	-0.2
Pavlov. Cond. lever latency	0.5	0.6	0.8	-0.9	0.8	0.8	-0.7	0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.5	-0.3	-0.3	0.1	-0.1
Pavlov. Cond. change in total contacts	0.6	0.7	0.8	-0.7	0.8	0.8	-0.9	0.9
Pavlov. Cond. index score	0.2	0.3	0.4	0.6	-0.6	-0.6	0.5	-0.4
Pavlov. Cond. latency score	0.1	0.1	0.1	0.3	-0.3	-0.3	0.2	-0.1
Pavlov. Cond. lever contacts	0.3	0.4	0.5	0.7	-0.7	-0.7	0.5	-0.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.3	0.2	0.2	0.0	-0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.1	-0.2	-0.2	0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.4	0.6	-0.6	-0.6	0.5	-0.5
Pavlov. Cond. response bias	0.8	1.0	1.4	1.2	-1.1	-1.1	0.8	-0.7
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.2	0.1	0.1	-0.2	0.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.1	-0.0	0.0	0.0
Pavlov. Cond. change in total contacts	0.1	0.3	0.5	-0.7	0.6	0.6	-0.5	0.4
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	0.2	0.2	-0.2	0.3
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.2	0.3	0.3	-0.3	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.4	-0.3	-0.3	0.3	-0.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	0.6	-0.7	-0.7	0.6	-0.7
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.1	-0.0	0.0	0.0	0.1
Pavlov. Cond. response bias	0.0	0.0	0.0	0.0	0.1	0.1	-0.0	0.1
Time in closed arm before self-admin	0.5	0.9	1.0	0.8	-1.0	-0.9	1.0	-1.0
Time in closed arm after self-admin	1.0	1.1	2.1	-1.5	1.0	1.0	-1.0	0.5
Time in open arm before self-admin	0.6	0.8	0.9	-0.7	0.9	0.9	-0.9	0.9
Time in open arm after self-admin	0.2	0.2	0.6	0.3	0.2	0.2	-0.2	0.8
Bone: periosteal estimation	0.3	0.6	1.1	1.0	-0.8	-0.8	0.8	-0.4
Bone: periosteal perimeter	0.3	0.6	1.1	1.1	-0.7	-0.7	0.7	-0.4
Bone: post-yield work	0.6	1.1	1.7	-0.7	1.0	1.0	-1.1	1.3
Progressive ratio test 1 active lever presses	2.0	3.5	5.5	2.3	-1.9	-1.9	1.8	-1.2
Progressive ratio test 1 breakpoint	1.9	3.2	5.7	2.4	-1.8	-1.8	1.7	-1.0
Progressive ratio test 1 inactive lever presses	0.8	2.1	3.4	1.8	-1.5	-1.5	1.4	-0.9
Progressive ratio test 2 active lever presses	2.1	2.9	4.4	2.1	-1.8	-1.8	1.7	-1.1
Progressive ratio test 2 breakpoint	2.5	3.2	4.7	2.2	-1.9	-1.9	1.7	-1.2
Progressive ratio test 2 inactive lever presses	0.2	0.6	1.8	1.4	-0.6	-0.7	0.5	0.4
Incentive Sensitization - Responses	0.6	1.7	2.3	1.5	-1.4	-1.4	1.3	-0.9
Incentive Sensitization - Breakpoint	0.7	1.5	2.0	1.4	-1.3	-1.3	1.2	-0.9
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.8	-0.9	0.5	0.5	-0.4	0.1
Progressive ratio	0.5	1.5	1.7	-1.3	1.2	1.2	-1.2	1.2
Food seeking constrained by brief footshock	5.2	6.5	6.8	-2.6	2.6	2.6	-2.5	2.5
Seeking ratio, punishment vs. effort	0.4	0.8	0.9	-0.7	0.9	1.0	-0.9	1.0
Retroperitoneal fat weight	0.0	0.1	0.3	0.5	-0.4	-0.4	0.3	-0.2
Reaction time number correct	2.0	7.2	9.9	2.1	-2.7	-2.6	2.8	-3.1
Reaction time mean minus median	0.1	0.6	1.8	-1.3	0.6	0.6	-0.3	-0.5
Reaction time mean minus median AUC	0.1	0.4	1.3	-0.6	-0.2	-0.1	0.4	-1.2
Reaction time num false alarms	3.7	6.3	8.8	3.0	-2.6	-2.6	2.5	-1.9
Reaction time num false alarms AUC	2.4	5.6	8.1	2.9	-2.4	-2.4	2.3	-1.7
Reaction time trials correct on left	2.0	7.2	9.9	2.1	-2.7	-2.6	2.8	-3.1
Reaction time trials on left	2.1	7.1	9.7	2.1	-2.7	-2.6	2.7	-3.1
Reaction time mean	0.9	2.1	2.9	-1.7	1.5	1.5	-1.4	1.0
Reaction time mean AUC	0.6	1.5	2.2	-1.5	1.3	1.3	-1.2	0.8
Median of all reaction times	1.5	2.3	2.5	-1.5	1.6	1.6	-1.5	1.4
Reaction time omissions	0.0	0.0	0.1	0.3	-0.0	-0.0	-0.1	0.2
Reaction time false alarm rate	0.3	0.4	1.2	1.1	-0.5	-0.5	0.4	0.2
Reaction time premature initiation rate	0.4	0.6	1.1	-0.5	0.8	0.8	-0.8	1.0
Reaction time premature initiations	0.1	0.4	0.5	0.5	-0.6	-0.6	0.6	-0.7
Std. dev. reaction times	0.2	0.6	1.5	-1.2	0.7	0.7	-0.5	-0.1
Reaction time trials completed	2.1	7.1	9.7	2.1	-2.7	-2.6	2.7	-3.1
Reaction time trials AUC	2.5	8.7	11.4	2.4	-3.0	-2.9	3.0	-3.4
Run reversals in cocaine runway, females	0.3	0.3	0.4	-0.5	0.5	0.5	-0.5	0.6
Run reversals in cocaine runway, males	0.4	0.5	0.5	0.6	-0.7	-0.7	0.7	-0.7
Latency to leave start box in cocaine runway	0.1	0.1	0.4	-0.3	-0.1	-0.0	0.2	-0.6
Latency to leave start box in cocaine runway, F	0.6	0.8	1.9	0.3	-0.7	-0.7	0.9	-1.4
Latency to leave start box in cocaine runway, M	0.2	0.2	0.2	-0.4	0.4	0.4	-0.4	0.4
Std. dev. time between licks in bursts	0.0	0.1	0.2	0.4	-0.1	-0.1	-0.1	0.2
Total sessions with >9 infusions	3.7	4.6	5.1	2.3	-2.2	-2.2	2.1	-2.0
Short access day 1 total inactive lever presses	0.7	1.4	4.1	2.0	-1.0	-1.0	0.8	0.3
Short access day 10 total inactive lever presses	0.2	1.3	1.4	-1.1	1.2	1.2	-1.1	1.2
Short access day 1 total infusions	1.4	2.7	3.4	1.8	-1.7	-1.7	1.6	-1.4
Short access day 10 total infusions	2.9	4.8	6.2	2.5	-2.2	-2.2	2.1	-1.7
Short access total infusions	2.2	3.0	4.4	2.1	-1.8	-1.8	1.7	-1.3
Short access day 1 locomotion	2.6	4.3	6.5	2.5	-2.1	-2.1	2.0	-1.5
Short access day 10 total locomotion	0.0	0.0	0.1	-0.2	-0.0	-0.0	0.0	-0.3
Short access total locomotion	0.6	0.9	1.4	1.2	-1.0	-1.0	0.9	-0.7
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.4	-0.2	-0.2	0.2	0.0
Compulsive drug intake	0.1	0.2	0.6	0.1	-0.4	-0.3	0.5	-0.8
One hour access (shock baseline)	0.5	1.4	2.2	1.5	-1.2	-1.2	1.1	-0.8
Social response proportion	0.7	0.9	1.4	0.6	-1.0	-0.9	0.9	-1.2
Social responses	0.7	1.0	1.0	1.0	-1.0	-1.0	1.0	-1.0
Social time	2.9	4.6	5.6	-1.9	2.1	2.1	-2.2	2.4
Soleus weight	0.1	0.3	0.5	0.7	-0.6	-0.6	0.6	-0.4
Bone: stiffness	0.7	1.3	1.7	1.3	-1.1	-1.1	1.2	-1.0
Tibialis anterior weight	3.3	11.4	14.4	3.8	-3.4	-3.4	3.4	-2.9
Time to tail flick, vehicle, before self-admin	2.3	2.9	3.2	1.4	-1.8	-1.8	1.8	-1.7
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.5	-0.5	0.0	0.0	0.1	-0.7
Time to tail flick, test, before self-admin	0.3	0.4	0.4	-0.6	0.6	0.6	-0.7	0.6
Time to tail flick, test, after self-admin	0.2	0.2	0.6	-0.1	0.3	0.3	-0.5	0.8
Delta time to tail flick, vehicle, before/after SA	0.1	0.2	0.3	-0.5	0.4	0.4	-0.4	-0.1
Delta time to tail flick, test, before/after SA	0.6	0.8	0.9	0.9	-0.9	-0.9	0.9	-0.7
Tibia length	0.2	0.6	1.2	1.1	-0.8	-0.8	0.6	-0.3
Ambulatory time before self-admin	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.1
Ambulatory time after self-admin	0.4	0.6	1.0	-1.0	0.8	0.8	-0.7	0.5
Bone: tissue strength	0.8	0.8	0.9	-0.9	0.9	0.9	-0.9	0.9
Total heroin consumption	0.0	0.0	0.1	0.2	0.0	0.0	-0.1	0.4
Bone: trabecular number	0.1	0.1	0.2	-0.1	0.2	0.3	-0.5	0.4
Bone: trabecular spacing	0.0	0.1	0.2	-0.0	-0.2	-0.2	0.4	-0.4
Bone: trabecular thickness	1.2	1.7	1.9	1.4	-1.4	-1.3	1.2	-1.2
Bone: trabecular tissue density	0.2	0.4	0.6	0.5	-0.7	-0.7	0.6	-0.8
Water consumed over 24 hours	0.1	0.2	0.4	-0.7	0.5	0.5	-0.5	0.2
Number of responses in last shaping day	2.5	3.2	4.1	1.5	-1.8	-1.8	1.8	-2.0