Hub : Genes

Sirt7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Sirt7	0.13	0.08	1.8e-09	0.09	0.07	0.08	0.08	8.6e-10	9.9e-09	2.9e-09	4.3e-09
2	Liver	gene expression	Sirt7	0.03	0.02	1.1e-03	0.03	0.01	0.02	0.02	1.0e-04	1.3e-02	5.2e-03	9.7e-04
3	LHb	intron excision ratio	chr10_105897165_105898265	0.31	0.16	1.9e-03	0.02	0.08	0.04	0.06	1.1e-01	5.9e-03	5.1e-02	1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.1	0.1	0.3	0.1	-0.0	0.6
Area under the delay curve	0.8	0.8	1.2	1.1	-1.1	0.2
BMI with tail	0.1	0.3	0.8	-0.2	0.2	0.9
BMI without tail	1.1	2.3	6.6	-0.5	0.4	2.6
Body weight	1.0	4.3	6.7	-2.6	2.5	-0.0
Weight adjusted by age	1.5	1.7	2.5	-1.6	1.5	-0.6
Bone surface	0.1	0.2	0.3	-0.6	0.5	-0.2
Bone volume	0.1	0.1	0.1	-0.4	0.3	0.2
Breakpoint value in progressive ratio session	1.8	2.0	2.4	-1.4	1.6	-1.2
Number of licking bursts	0.2	0.2	0.5	0.4	-0.3	0.7
Context. condit. distance diff. score	1.7	2.1	4.0	1.1	-1.0	2.0
Locomotion velocity, session 1	0.6	0.6	1.8	0.0	-0.1	-1.3
Locomotion distance, session 1	2.9	3.7	4.7	2.1	-2.2	1.4
Locomotion velocity, session 2	1.2	1.4	2.3	1.4	-1.5	-0.2
Locomotion distance, session 2	1.3	1.8	1.9	1.3	-1.4	1.3
Locomotion velocity, session 3	0.2	0.2	0.5	0.4	-0.3	-0.7
Locomotion distance, session 3	0.9	1.0	1.5	1.2	-1.2	0.1
Stereotopy head waving bouts, day 3	0.1	0.2	0.5	0.0	-0.0	-0.7
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.2	-0.2	-0.2
Locomotion velocity, session 7	0.4	0.4	0.6	0.8	-0.7	0.4
Locomotion distance, session 7	3.9	5.0	6.0	2.4	-2.3	1.9
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.2	0.0	0.1
Stereotopy head waving duration, day 7	0.2	0.2	0.3	-0.6	0.4	-0.3
Locomotion velocity, session 8	2.1	2.5	2.7	1.6	-1.5	1.6
Locomotion distance, session 8	4.3	6.2	9.7	2.1	-2.1	3.1
Degree of sensitization distance	0.5	0.5	1.2	0.4	-0.2	1.1
Degree of sensitization stereotypy	0.0	0.0	0.1	-0.3	0.1	0.2
Conditioned locomotion	0.5	0.6	0.9	-0.7	0.7	1.0
Cocaine response after cond. corrected	0.3	0.3	0.4	-0.5	0.5	-0.7
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.0	0.0	-0.4
Cocaine response before conditioning	0.9	1.1	1.4	1.2	-1.2	0.7
Saline control response	0.9	1.2	1.9	-1.4	1.3	-0.1
Bone: connectivity density	0.6	0.9	1.2	0.9	-0.9	1.1
Bone: cortical apparent density	0.4	0.6	0.9	0.9	-1.0	-0.2
Bone: cortical area	3.6	5.4	7.7	-2.7	2.8	-1.0
Bone: cortical porosity	5.8	6.3	7.1	-2.4	2.5	-2.7
Bone: cortical porosity	4.6	5.0	5.2	-2.2	2.3	-2.2
Bone: cortical thickness	4.8	7.8	10.2	-3.2	3.2	-1.8
Bone: cortical thickness	1.5	1.7	2.4	-1.5	1.6	-0.8
Bone: cortical tissue density	0.5	0.7	1.1	1.0	-1.0	-0.2
Condit. Reinf. active minus inactive responses	0.4	0.4	0.7	-0.8	0.8	0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.6	0.5	0.1
Condit. Reinf. active responses	0.6	0.8	1.2	-1.1	1.0	0.4
Condit. Reinf. inactive responses	0.2	0.2	0.3	-0.5	0.5	0.2
Incentive salience index mean	0.2	0.3	0.4	-0.6	0.5	0.3
Condit. Reinf. lever presses	0.4	0.5	0.7	0.6	-0.8	0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.5	0.3	0.2
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.2	-1.5	1.3	-0.7
Condit. Reinf. active responses	0.1	0.2	0.4	0.1	-0.2	0.6
Condit. Reinf. inactive responses	0.7	0.9	1.1	1.1	-1.0	0.8
Condit. Reinf. lever presses	0.3	0.4	1.0	0.3	-0.4	1.0
Condit. Reinf. lever reinforcers received	0.3	0.4	0.8	0.3	-0.4	0.9
Conditioned reinforcement - actives	0.6	0.6	0.7	0.8	-0.7	0.8
Conditioned reinforcement - inactives	1.1	1.2	2.1	-1.1	1.5	-0.4
Conditioned locomotion	0.0	0.0	0.1	0.2	-0.2	0.2
Patch foraging indifference point 0 sec	0.1	0.1	0.2	-0.5	0.5	-0.1
Patch foraging indifference point AUC	0.1	0.1	0.1	0.2	-0.3	0.3
Delay disc. indifference point, 0s delay	0.0	0.1	0.1	0.3	-0.3	0.1
Delay disc. indifference point, 16s delay	3.7	3.7	4.4	2.1	-2.1	1.5
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	0.3	-0.3	-0.3
Delay disc. indifference point, 24s delay	0.9	0.9	1.2	1.1	-1.1	-0.6
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	0.3	-0.3	-0.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	0.2	-0.2	-0.7
Indifference point function ln k	0.3	0.5	0.7	0.8	-0.8	0.4
Indifference point function log k	0.3	0.5	0.7	0.8	-0.8	0.4
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	-0.3	0.3	0.1
Patch foraging total patch changes 12 sec	0.2	0.2	0.3	-0.6	0.5	-0.4
Patch foraging total patch changes 18 sec	0.5	0.7	1.1	0.6	-0.8	1.0
Patch foraging total patch changes 24 sec	0.2	0.2	0.3	-0.5	0.5	0.2
Patch foraging total patch changes 6 sec	0.6	0.9	1.2	-1.1	1.0	-0.6
Patch foraging time to switch 0 sec	0.1	0.1	0.2	0.4	-0.4	-0.2
Patch foraging water rate 0 sec	0.3	0.5	0.5	-0.7	0.7	0.7
Patch foraging water rate 12 sec	0.5	0.8	1.6	0.6	-0.7	1.3
Patch foraging water rate 18 sec	0.6	0.7	1.8	0.4	-0.5	1.3
Patch foraging water rate 24 sec	0.9	1.2	3.3	0.4	-0.3	1.8
Patch foraging water rate 6 sec	0.3	0.4	0.7	0.5	-0.6	0.8
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.7	-0.7	0.8	0.1
Distance traveled before self-admin	2.9	3.1	3.7	-1.9	1.9	-1.4
Distance traveled after self-admin	0.2	0.2	0.4	-0.1	0.4	0.7
Extensor digitorum longus weight	0.6	2.3	4.5	0.9	-1.3	2.1
Bone: elastic displacement	1.6	1.8	2.3	-1.5	1.5	-0.9
Bone: elastic work	9.4	12.1	15.0	-3.9	3.9	-2.5
Bone: endosteal estimation	0.5	1.1	1.8	0.9	-0.9	1.3
Bone: endosteal perimeter	0.3	0.6	0.9	-1.0	0.9	-0.3
Epididymis fat weight	0.1	0.3	0.6	-0.3	0.4	0.8
Delta time in closed arm before/after self-admin	0.4	0.4	0.6	0.7	-0.8	0.5
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.2	-0.2	0.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.1	0.1	-0.4
Delay discount exponential model param	0.7	0.7	1.1	-1.0	1.0	0.1
Extinction: sum of active levers before priming	0.2	0.2	0.5	0.3	-0.4	-0.7
Active lever presses in extinction session 6	1.0	1.0	1.8	-0.8	0.8	-1.3
Bone: final force	2.6	4.2	6.2	-2.5	2.5	-0.7
Bone: final moment	3.6	5.8	8.3	-2.9	2.9	-1.0
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.4	0.4	0.1
Glucose	2.2	3.3	8.3	-0.9	0.9	-2.9
Heart weight	0.2	0.3	0.4	-0.6	0.6	-0.2
Delay discount hyperbolic model param	0.7	0.7	1.1	-1.0	1.0	0.0
Intermittent access intake day 1-15 change	0.8	0.8	1.2	-1.1	1.0	-0.4
Intermittent access intake escalation	0.4	0.3	0.6	-0.8	0.7	-0.1
Intermittent access intake escalation 2	2.9	2.8	4.0	-2.0	1.6	-1.3
Intermitt. access day 1 inactive lever presses	1.4	1.5	2.1	-1.4	1.4	-0.7
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.4	-0.1	0.2	0.6
Intermitt. access escalation Index	0.7	0.6	1.4	0.6	-0.4	1.2
Intermittent access day 1 total infusions	0.1	0.1	0.3	-0.3	0.5	0.2
Intermittent access day 15 total infusions	0.2	0.2	0.4	-0.4	0.6	0.3
Intermittent access terminal intake (last 3 days)	0.5	0.6	1.1	-0.8	1.0	-0.1
Intermittent access total infusions	0.2	0.2	0.4	-0.3	0.6	0.3
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.1	-0.0	0.5
Intermittent access day 15 total locomotion	0.3	0.4	0.5	-0.7	0.7	-0.4
Intermittent access total locomotion	0.1	0.1	0.2	-0.4	0.5	0.0
Intermittent access standard deviation	1.5	1.6	2.6	-1.1	1.1	-1.6
Left kidney weight	0.3	0.8	0.9	-0.7	0.9	-0.9
Right kidney weight	0.0	0.0	0.1	0.0	0.1	-0.3
Cocaine induced anxiety	8.4	9.7	11.9	-3.4	3.4	-2.4
Post-drug Anxiety	2.3	2.5	2.9	-1.7	1.7	-1.4
Baseline Anxiety	6.3	6.7	9.4	3.1	-3.0	1.4
Tail length	0.9	2.6	3.5	-1.9	1.7	1.2
Length with tail	1.4	5.1	7.2	-2.7	2.6	-1.1
Length without tail	1.8	3.9	7.5	-1.5	1.5	-2.7
Times rat made contact with spout	3.0	3.4	3.8	-1.9	1.9	-1.7
Lifetime Intake	0.0	0.1	0.1	-0.1	0.4	0.2
Liver weight, left	0.8	1.3	2.2	-0.9	0.9	-1.5
Liver weight, right	0.8	1.4	1.9	-1.4	1.3	-0.6
Locomotor activity	0.2	0.2	0.4	0.6	-0.6	-0.0
Locomotor testing distance	0.7	1.2	1.7	1.3	-1.2	0.6
Locomotor testing rearing	0.5	0.8	1.0	1.0	-1.0	0.7
Locomotion in novel chamber	0.7	0.8	1.0	1.0	-1.0	0.7
Locomotion in novel chamber post-restriction	1.1	1.3	1.9	-1.4	1.4	-0.2
Fecal boli incidents, locomotor time 1	0.6	0.6	0.8	0.9	-0.9	0.5
Change in fecal boli incidents, locomotor task	0.9	0.9	2.1	-0.5	0.5	-1.4
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.8	0.7	-0.7	1.3
Bouts of movement, locomotor time 1	0.4	0.4	0.7	0.8	-0.8	-0.1
Total resting periods, locomotor time 1	0.3	0.3	0.4	0.6	-0.6	-0.4
Rest time, locomotor task time 1	0.3	0.3	0.7	-0.4	0.4	-0.8
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.0	0.0	0.5
Vertical activity count, locomotor time 1	0.5	0.5	1.2	0.4	-0.4	1.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	0.3	-0.3	0.3
Bouts of movement, locomotor time 2	1.0	1.0	1.4	1.2	-1.2	0.6
Total resting periods, locomotor time 2	1.4	1.4	1.8	1.3	-1.3	0.9
Rest time, locomotor task time 2	0.0	0.0	0.0	0.2	-0.2	-0.1
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.1	-0.1	0.2
Vertical activity count, locomotor time 2	0.9	1.0	1.3	0.9	-0.9	1.1
Light reinforcement 1	0.4	0.8	2.0	0.4	-0.4	1.4
Light reinforcement 2	0.2	0.2	0.4	-0.4	0.4	0.6
Bone: marrow area	0.5	1.1	1.7	0.9	-0.9	1.3
Bone: maximum diameter	0.7	1.3	1.8	-1.3	1.3	-0.4
Bone: maximum force	2.1	3.6	5.3	-2.3	2.3	-0.4
Bone: maximum moment	2.9	5.0	7.2	-2.7	2.7	-0.7
Mean time between licks in bursts	0.9	1.3	1.9	1.4	-1.3	0.6
Mean num. licks in bursts	1.4	1.7	1.8	-1.3	1.3	-1.3
Cd content in liver	1.2	1.3	1.7	1.3	-1.3	0.7
Co content in liver	0.0	0.1	0.1	0.2	-0.2	0.2
Cu content in liver	2.1	2.5	2.9	-1.4	1.7	-1.7
Fe content in liver	0.6	0.7	1.0	1.0	-0.9	0.5
K content in liver	0.3	0.3	0.7	-0.1	0.3	0.8
Mg content in liver	2.1	2.2	3.4	1.4	-1.1	1.8
Mn content in liver	0.1	0.1	0.2	-0.4	0.5	-0.3
Na content in liver	0.0	0.0	0.0	-0.0	0.1	-0.2
Rb content in liver	0.4	0.4	1.2	0.4	-0.1	1.1
Se content in liver	0.0	0.0	0.1	-0.1	0.2	0.2
Sr content in liver	2.2	2.1	3.4	-1.2	1.2	-1.8
Zn content in liver	0.1	0.1	0.1	0.1	0.2	-0.4
Bone: minimum diameter	2.0	3.7	5.3	-2.3	2.3	-0.8
Time in familiar zone, hab. session 1	0.2	0.2	0.2	-0.3	0.4	-0.5
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.2	-0.4	0.4
Total zone transitions, hab. session 1	0.4	0.6	0.7	0.8	-0.8	0.7
Total locomotion distance, hab. session 1	0.3	0.4	1.0	0.4	-0.4	1.0
Locomotion velocity, hab. session 1	0.3	0.4	1.0	0.4	-0.3	1.0
Time in familiar zone, hab. session 2	0.3	0.3	0.3	0.6	-0.5	0.5
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	-0.3	-0.0
Total zone transitions, hab. session 2	2.8	3.6	4.5	1.7	-1.8	2.1
Total locomotion distance, hab. session 2	2.0	2.6	4.8	1.2	-1.3	2.2
Locomotion velocity, hab. session 2	1.5	2.0	4.2	0.9	-0.9	2.1
Novel to familiar place preference ratio	3.7	3.8	4.7	-2.1	2.2	-1.5
Novelty place preference	3.8	3.9	4.8	-2.1	2.2	-1.6
Time in novel zone, NPP test	2.7	2.8	3.5	-1.8	1.9	-1.3
Total zone transitions, NPP test	3.9	5.6	6.6	2.2	-2.3	2.6
Total locomotion distance, NPP test	3.5	4.8	7.3	1.9	-1.9	2.7
Locomotion velocity, NPP test	2.0	2.9	4.9	1.4	-1.4	2.2
Intraocular pressure	0.1	0.1	0.3	-0.2	0.1	0.6
Delta distance traveled before/after self-admin	1.8	2.0	2.3	1.5	-1.2	1.5
Delta ambulatory time before/after self-admin	2.6	2.8	3.5	1.9	-1.6	1.5
Parametrial fat weight	0.7	1.4	2.2	-1.4	1.5	-0.3
Pavlov. Cond. lever latency	2.9	3.7	4.4	2.0	-1.7	2.1
Pavlov. Cond. magazine entry latency	4.0	5.2	6.3	-2.5	2.3	-2.0
Pavlov. Cond. change in total contacts	2.5	2.7	3.3	-1.7	1.4	-1.8
Pavlov. Cond. index score	3.5	4.5	5.7	-2.4	2.2	-1.7
Pavlov. Cond. latency score	3.7	4.7	5.6	-2.4	2.2	-1.9
Pavlov. Cond. lever contacts	1.3	1.6	1.8	-1.4	1.2	-1.2
Pavlov. Cond. magazine entry number	5.4	6.7	7.6	2.8	-2.5	2.5
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.5	0.6	-0.5	1.2
Pavlov. Cond. lever-magazine prob. diff.	3.8	4.7	6.0	-2.5	2.3	-1.7
Pavlov. Cond. response bias	4.4	5.3	6.2	-2.5	2.3	-2.1
Pavlov. Cond. lever latency	0.5	0.7	1.7	-0.4	0.4	-1.3
Pavlov. Cond. magazine entry latency	2.8	3.3	3.6	1.9	-1.9	1.6
Pavlov. Cond. change in total contacts	1.0	1.4	1.9	1.1	-1.1	1.4
Pavlov. Cond. index score	1.0	1.3	1.8	1.0	-1.0	1.3
Pavlov. Cond. latency score	1.2	1.5	2.2	1.1	-1.1	1.5
Pavlov. Cond. lever contacts	0.6	0.9	2.2	0.4	-0.5	1.5
Pavlov. Cond. magazine entry number	2.5	3.0	3.2	-1.8	1.8	-1.7
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	-0.8	0.8	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	1.9	1.1	-1.1	1.4
Pavlov. Cond. response bias	0.9	1.2	2.0	0.8	-0.9	1.4
Time in closed arm before self-admin	0.8	0.9	1.1	-0.8	1.0	-1.0
Time in closed arm after self-admin	1.3	1.3	2.5	-0.8	0.9	-1.6
Time in open arm before self-admin	0.9	0.9	1.5	1.0	-1.2	0.6
Time in open arm after self-admin	0.9	1.0	1.2	1.0	-1.1	0.9
Bone: periosteal estimation	0.5	1.1	1.7	-1.3	1.3	0.1
Bone: periosteal perimeter	3.6	6.0	7.4	-2.7	2.7	-1.8
Bone: post-yield work	0.6	0.8	1.1	0.8	-0.9	1.0
Progressive ratio test 1 active lever presses	0.3	0.3	0.5	-0.5	0.7	0.3
Progressive ratio test 1 breakpoint	0.4	0.4	0.8	-0.6	0.9	0.2
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.7	-0.8	0.8	0.4
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	-0.4	0.7	-0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.2	0.4	0.3
Progressive ratio test 2 inactive lever presses	0.4	0.5	0.8	-0.7	0.9	-0.4
Incentive Sensitization - Responses	0.2	0.2	0.4	-0.4	0.6	0.0
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	-0.4	0.6	-0.1
Sum of active levers in priming session hrs 5-6	1.9	1.8	2.3	-1.5	1.5	-1.0
Progressive ratio	0.1	0.1	0.2	0.5	-0.4	-0.0
Food seeking constrained by brief footshock	0.3	0.4	0.7	-0.4	0.4	-0.8
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.2	0.1	0.1
Retroperitoneal fat weight	1.2	3.9	6.3	-2.3	2.5	0.0
Reaction time number correct	6.1	8.7	12.6	2.6	-2.6	3.5
Reaction time mean minus median	0.5	0.6	1.2	-0.6	0.5	-1.1
Reaction time mean minus median AUC	0.1	0.1	0.2	-0.2	0.1	-0.4
Reaction time num false alarms	0.1	0.1	0.2	0.4	-0.2	0.1
Reaction time num false alarms AUC	0.4	0.5	0.8	0.9	-0.7	0.4
Reaction time trials correct on left	6.1	8.7	12.6	2.6	-2.6	3.5
Reaction time trials on left	6.3	9.1	13.0	2.6	-2.7	3.6
Reaction time mean	0.0	0.0	0.0	-0.2	0.1	0.2
Reaction time mean AUC	0.1	0.2	0.5	0.3	-0.3	0.7
Median of all reaction times	0.1	0.1	0.3	0.0	-0.1	0.6
Reaction time omissions	0.1	0.2	0.4	0.3	-0.3	0.6
Reaction time false alarm rate	0.7	0.9	2.1	-0.5	0.7	-1.4
Reaction time premature initiation rate	0.3	0.4	0.6	0.7	-0.8	0.1
Reaction time premature initiations	2.9	4.1	4.3	2.0	-2.1	2.0
Std. dev. reaction times	0.1	0.2	0.3	0.5	-0.6	0.1
Reaction time trials completed	6.3	9.1	13.0	2.6	-2.7	3.6
Reaction time trials AUC	6.1	8.8	12.8	2.6	-2.6	3.6
Run reversals in cocaine runway, females	1.7	1.6	1.7	1.3	-1.3	1.2
Run reversals in cocaine runway, males	3.1	3.0	3.4	-1.8	1.8	-1.5
Latency to leave start box in cocaine runway	0.4	0.4	0.5	0.7	-0.7	0.6
Latency to leave start box in cocaine runway, F	1.8	1.9	2.0	1.4	-1.4	1.4
Latency to leave start box in cocaine runway, M	0.3	0.3	0.3	-0.6	0.6	-0.4
Std. dev. time between licks in bursts	2.9	3.5	6.5	1.4	-1.5	2.5
Total sessions with >9 infusions	0.2	0.2	0.5	0.7	-0.4	0.3
Short access day 1 total inactive lever presses	1.2	1.3	1.4	1.2	-1.1	1.2
Short access day 10 total inactive lever presses	1.9	2.1	3.4	-1.9	1.6	-0.5
Short access day 1 total infusions	0.5	0.6	0.9	1.0	-0.9	0.0
Short access day 10 total infusions	0.6	0.7	1.2	-0.9	1.1	-0.4
Short access total infusions	0.0	0.0	0.0	0.0	0.2	-0.0
Short access day 1 locomotion	0.1	0.1	0.4	-0.0	0.0	-0.7
Short access day 10 total locomotion	0.6	0.7	1.3	-0.7	0.6	-1.2
Short access total locomotion	0.2	0.2	0.5	-0.1	0.2	-0.7
One hour access (0.3 mA shock)	0.3	0.4	0.6	-0.5	0.8	0.5
Compulsive drug intake	0.2	0.2	0.3	-0.2	0.5	0.4
One hour access (shock baseline)	0.1	0.2	0.3	0.3	-0.3	0.5
Social response proportion	0.7	0.7	0.9	0.9	-1.0	0.7
Social responses	0.2	0.3	0.3	0.6	-0.6	0.5
Social time	0.3	0.3	0.3	0.6	-0.6	0.6
Soleus weight	0.3	0.8	1.4	-1.2	1.0	0.2
Bone: stiffness	0.1	0.2	0.2	-0.5	0.5	0.2
Tibialis anterior weight	0.2	0.6	1.1	0.4	-0.7	1.0
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.1	-0.1	0.3
Time to tail flick, vehicle, after self-admin	1.0	1.1	1.9	1.4	-1.1	0.4
Time to tail flick, test, before self-admin	0.3	0.3	0.3	-0.6	0.6	-0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	0.1	-0.2
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.1	1.1	-0.9	0.8
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.1	0.0	-0.5
Tibia length	7.2	20.2	27.5	-5.2	5.0	-2.8
Ambulatory time before self-admin	3.2	3.3	4.4	-2.1	2.0	-1.3
Ambulatory time after self-admin	0.1	0.1	0.2	-0.2	0.5	0.3
Bone: tissue strength	0.2	0.2	0.6	-0.2	0.2	0.8
Total heroin consumption	1.4	1.7	2.0	-1.1	1.3	-1.4
Bone: trabecular number	0.0	0.0	0.0	0.2	-0.1	0.2
Bone: trabecular spacing	2.4	3.1	5.5	1.4	-1.4	2.4
Bone: trabecular thickness	3.0	3.6	4.0	-1.8	1.9	-2.0
Bone: trabecular tissue density	0.3	0.4	0.7	0.8	-0.8	0.1
Water consumed over 24 hours	0.7	0.8	1.3	-0.7	0.7	-1.1
Number of responses in last shaping day	0.1	0.1	0.1	-0.2	0.3	0.2