Hub : Genes

Sirt6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Sirt6 0.02 0.02 8.6e-03 0.02 0.01 0.02 0.01 6.2e-03 1.2e-02 5.5e-03 1.1e-02
2 NAcc gene expression Sirt6 0.06 0.05 1.2e-05 0.05 0.04 0.04 0.04 2.6e-06 2.7e-05 2.0e-05 6.6e-06
3 NAcc mRNA stability Sirt6 0.05 0.04 2.1e-06 0.05 0.05 0.06 0.05 7.4e-07 1.0e-06 4.1e-07 1.1e-06
4 PL mRNA stability Sirt6 0.06 0.04 1.2e-06 0.06 0.05 0.05 0.05 1.1e-06 1.6e-06 5.3e-06 2.6e-06
5 BLA mRNA stability Sirt6 0.05 0.04 4.4e-03 0.04 0.02 0.02 0.02 5.8e-03 1.8e-02 3.3e-02 3.1e-02
6 Brain gene expression Sirt6 0.08 0.05 3.6e-06 0.05 0.04 0.05 0.04 4.3e-05 7.9e-05 2.8e-05 1.2e-04
7 BLA gene expression Sirt6 0.09 0.06 4.5e-05 0.09 0.09 0.09 0.09 1.1e-05 1.0e-05 1.6e-05 1.3e-05
8 RMTg alternative TSS NM_001031649.1 0.14 0.1 9.8e-03 0.04 0.02 0.02 0.02 3.1e-02 7.5e-02 9.9e-02 1.2e-01
9 OFC gene expression Sirt6 0.15 0.1 1.2e-03 0.13 0.11 0.12 0.12 6.0e-04 1.5e-03 8.1e-04 1.0e-03
10 PL gene expression Sirt6 0.04 0.03 1.8e-05 0.05 0.04 0.04 0.05 2.9e-06 1.0e-05 1.5e-05 4.8e-06
11 LHb gene expression Sirt6 0.15 0.11 8.0e-03 0.04 0.06 0.06 0.05 4.6e-02 1.3e-02 1.5e-02 2.1e-02
12 Brain mRNA stability Sirt6 0.04 0.03 5.0e-03 0.01 0.01 0.02 0.01 5.6e-02 2.8e-02 9.6e-03 4.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.11.94.50.5-1.21.01.11.2-1.61.20.6-1.6-1.61.92.1
Area under the delay curve1.31.42.6-1.31.2-1.3-1.2-1.21.0-1.11.61.21.2-0.8-0.6
BMI with tail6.119.829.9-5.54.6-4.7-4.6-4.64.3-4.54.64.34.3-3.8-3.4
BMI without tail3.06.213.7-3.72.5-2.4-2.7-2.42.4-2.42.02.42.4-2.3-2.1
Body weight1.24.96.0-2.12.4-2.4-2.2-2.32.3-2.32.22.32.3-2.0-1.8
Weight adjusted by age0.70.82.5-1.60.8-0.6-1.1-0.70.8-0.90.40.80.8-1.0-0.8
Bone surface3.25.611.91.2-2.22.02.22.2-2.72.30.3-2.5-2.53.23.4
Bone volume3.35.611.81.2-2.22.02.22.2-2.72.30.3-2.6-2.63.23.4
Breakpoint value in progressive ratio session3.43.87.01.9-1.92.12.02.0-1.71.9-2.6-2.0-2.01.31.1
Number of licking bursts0.50.61.5-0.40.8-0.7-0.6-0.81.0-0.8-0.00.30.3-1.1-1.2
Context. condit. distance diff. score0.40.50.9-0.70.7-0.7-0.6-0.60.7-0.70.60.90.9-0.6-0.6
Locomotion velocity, session 11.31.42.51.0-1.31.21.31.3-1.41.4-0.6-0.5-0.51.51.6
Locomotion distance, session 10.70.92.50.5-1.00.80.90.9-1.21.10.1-0.2-0.21.51.6
Locomotion velocity, session 25.46.38.02.3-2.72.62.72.6-2.82.7-1.6-2.1-2.12.82.8
Locomotion distance, session 22.73.85.91.6-2.12.02.12.0-2.32.2-0.9-1.3-1.32.42.4
Locomotion velocity, session 35.16.07.62.7-2.52.62.52.6-2.32.5-2.8-2.4-2.42.01.7
Locomotion distance, session 30.00.00.00.1-0.00.1-0.00.00.00.0-0.20.00.0-0.1-0.1
Stereotopy head waving bouts, day 34.95.86.42.5-2.52.52.52.5-2.52.5-2.2-2.4-2.42.32.1
Stereotopy head waving duration, day 35.36.37.12.7-2.62.72.62.6-2.52.6-2.5-2.4-2.42.32.1
Locomotion velocity, session 71.01.11.51.0-1.11.01.11.0-1.11.1-0.8-1.2-1.21.11.0
Locomotion distance, session 70.20.30.7-0.30.5-0.5-0.5-0.50.6-0.50.00.40.4-0.7-0.8
Stereotopy head waving bouts, day 70.30.41.20.2-0.50.50.60.6-0.80.60.2-0.1-0.11.01.1
Stereotopy head waving duration, day 70.80.92.20.6-0.90.91.01.0-1.21.0-0.1-0.7-0.71.41.5
Locomotion velocity, session 81.51.83.90.9-1.41.31.41.4-1.61.4-0.3-0.9-0.91.82.0
Locomotion distance, session 80.20.20.50.4-0.60.50.50.5-0.60.6-0.10.00.00.70.7
Degree of sensitization distance0.30.30.5-0.60.6-0.6-0.5-0.60.5-0.60.70.50.5-0.5-0.4
Degree of sensitization stereotypy0.80.92.6-1.30.9-1.0-0.8-0.90.6-0.81.61.11.1-0.3-0.1
Conditioned locomotion3.03.54.6-1.72.0-1.9-2.0-2.02.1-2.01.11.71.7-2.1-2.1
Cocaine response after cond. corrected7.48.39.8-2.72.9-2.9-2.9-3.03.0-2.92.13.13.1-2.9-2.8
Cocaine response after cond. not corrected8.18.910.1-2.83.1-3.0-3.0-3.13.1-3.02.13.23.2-3.1-3.0
Cocaine response before conditioning0.70.91.30.8-0.90.90.90.9-1.00.9-0.7-1.1-1.10.90.9
Saline control response0.10.20.3-0.30.4-0.4-0.4-0.40.5-0.40.20.50.5-0.5-0.5
Bone: connectivity density0.40.61.9-0.1-0.60.40.50.5-0.80.60.9-0.8-0.81.21.4
Bone: cortical apparent density1.01.41.8-1.21.3-1.2-1.1-1.11.1-1.21.21.41.4-1.0-0.8
Bone: cortical area0.20.21.5-0.60.2-0.3-0.2-0.1-0.1-0.21.2-0.2-0.20.40.6
Bone: cortical porosity0.91.01.30.9-1.01.01.01.0-1.01.0-0.6-1.1-1.11.01.1
Bone: cortical porosity0.40.41.00.3-0.60.50.60.6-0.80.60.1-0.7-0.70.91.0
Bone: cortical thickness0.61.02.5-1.31.0-1.1-1.0-1.00.8-1.01.60.80.8-0.6-0.4
Bone: cortical thickness0.10.10.4-0.10.3-0.3-0.3-0.30.4-0.3-0.20.20.2-0.5-0.6
Bone: cortical tissue density0.81.11.5-1.01.1-1.1-0.9-1.01.0-1.10.91.21.2-0.9-0.7
Condit. Reinf. active minus inactive responses3.84.25.82.4-2.22.22.22.1-2.02.1-2.1-1.9-1.91.81.6
Condit. Reinf. active-inactive response ratio1.31.42.81.5-1.21.31.31.2-1.01.2-1.7-1.2-1.20.70.6
Condit. Reinf. active responses4.35.36.12.5-2.42.42.42.4-2.42.4-1.9-2.2-2.22.32.2
Condit. Reinf. inactive responses1.72.02.81.3-1.51.31.41.4-1.61.5-0.6-1.4-1.41.71.7
Incentive salience index mean2.83.43.91.9-1.91.92.01.9-1.91.9-1.4-1.7-1.71.91.8
Condit. Reinf. lever presses0.81.02.70.5-0.90.81.00.9-1.21.00.3-0.8-0.81.51.7
Condit. Reinf. active minus inactive responses1.31.73.71.6-1.21.31.21.2-1.01.2-1.9-1.5-1.50.60.4
Condit. Reinf. active-inactive response ratio0.30.31.20.10.4-0.3-0.4-0.40.6-0.4-0.70.20.2-0.9-1.1
Condit. Reinf. active responses2.12.94.01.9-1.71.71.71.7-1.51.7-1.8-2.0-2.01.31.1
Condit. Reinf. inactive responses1.82.22.71.4-1.61.51.51.5-1.51.5-1.0-1.6-1.61.51.4
Condit. Reinf. lever presses1.52.14.01.8-1.41.51.41.4-1.21.4-2.0-1.6-1.60.90.6
Condit. Reinf. lever reinforcers received1.41.92.91.6-1.41.41.31.3-1.21.3-1.7-1.7-1.70.90.7
Conditioned reinforcement - actives2.62.63.21.0-1.71.81.61.7-1.71.7-1.7-1.7-1.71.51.4
Conditioned reinforcement - inactives1.41.62.30.21.4-1.4-1.0-1.41.5-1.30.61.41.4-1.5-1.5
Conditioned locomotion7.18.510.33.0-3.03.13.03.0-2.83.0-3.2-3.0-3.02.42.1
Patch foraging indifference point 0 sec0.10.20.40.20.4-0.5-0.2-0.50.4-0.40.60.40.4-0.3-0.3
Patch foraging indifference point AUC0.80.91.40.3-1.11.10.81.1-1.01.0-1.2-1.0-1.00.80.7
Delay disc. indifference point, 0s delay3.43.89.8-2.32.0-2.1-1.9-1.91.5-1.83.12.02.0-0.8-0.4
Delay disc. indifference point, 16s delay0.10.10.2-0.20.3-0.3-0.3-0.30.2-0.20.40.30.3-0.1-0.1
Delay disc. indifference point, 2s delay3.53.97.3-2.32.0-2.2-2.0-2.01.7-1.92.72.02.0-1.2-0.9
Delay disc. indifference point, 24s delay0.40.40.7-0.50.6-0.7-0.8-0.80.6-0.60.70.60.6-0.5-0.4
Delay disc. indifference point, 4s delay0.40.41.6-0.90.5-0.7-0.6-0.60.3-0.41.30.50.50.00.2
Delay disc. indifference point, 8s delay1.31.41.5-1.21.2-1.2-1.2-1.11.2-1.21.01.21.2-1.2-1.2
Indifference point function ln k0.30.40.50.00.7-0.7-0.5-0.70.7-0.70.60.60.6-0.6-0.6
Indifference point function log k0.30.40.50.00.7-0.7-0.5-0.70.7-0.70.60.60.6-0.6-0.6
Patch foraging total patch changes 0 sec0.10.20.30.20.5-0.5-0.2-0.50.5-0.40.50.40.4-0.4-0.4
Patch foraging total patch changes 12 sec0.70.91.4-1.20.9-0.9-1.1-1.01.0-0.90.50.80.8-1.0-1.1
Patch foraging total patch changes 18 sec0.81.01.30.9-1.01.11.11.1-1.01.0-1.2-1.1-1.10.80.7
Patch foraging total patch changes 24 sec0.10.20.2-0.3-0.40.40.20.4-0.50.4-0.2-0.4-0.40.40.4
Patch foraging total patch changes 6 sec0.20.31.51.2-0.40.30.70.3-0.30.4-0.4-0.3-0.30.30.2
Patch foraging time to switch 0 sec0.71.03.5-0.91.1-1.2-1.0-1.10.8-0.91.90.90.9-0.4-0.2
Patch foraging water rate 0 sec0.20.31.1-0.10.3-0.3-0.4-0.50.6-0.5-0.50.50.5-0.9-1.0
Patch foraging water rate 12 sec2.03.14.0-2.01.8-1.6-1.7-1.71.9-1.80.81.81.8-2.0-2.0
Patch foraging water rate 18 sec0.81.03.4-0.50.7-0.6-0.7-0.81.1-0.9-0.80.80.8-1.6-1.8
Patch foraging water rate 24 sec2.53.58.0-0.31.8-1.7-1.6-1.92.2-1.9-0.11.81.8-2.6-2.8
Patch foraging water rate 6 sec0.20.31.20.60.10.0-0.1-0.10.4-0.1-1.10.00.0-0.7-1.0
Seeking ratio, delayed vs. immediate footshock5.96.88.12.8-2.72.72.82.6-2.62.6-2.3-2.7-2.72.42.2
Distance traveled before self-admin0.10.10.4-0.60.2-0.2-0.4-0.20.1-0.20.60.30.3-0.00.0
Distance traveled after self-admin1.11.21.51.2-1.21.21.01.1-1.11.1-0.9-1.1-1.11.00.9
Extensor digitorum longus weight5.019.722.4-4.54.7-4.7-4.6-4.64.6-4.73.94.14.1-4.4-4.1
Bone: elastic displacement0.30.30.40.6-0.60.60.60.7-0.60.6-0.6-0.4-0.40.50.5
Bone: elastic work0.10.10.3-0.30.2-0.2-0.1-0.10.0-0.10.60.30.30.10.2
Bone: endosteal estimation0.10.10.7-0.50.3-0.3-0.2-0.20.1-0.20.80.20.20.10.3
Bone: endosteal perimeter0.71.52.40.9-1.21.11.21.3-1.31.2-0.4-1.3-1.31.41.5
Epididymis fat weight0.00.10.60.2-0.30.40.10.3-0.10.2-0.8-0.3-0.3-0.1-0.2
Delta time in closed arm before/after self-admin2.42.34.5-1.11.5-1.3-1.6-1.41.7-1.50.31.41.4-2.0-2.1
Delta time in open arm before/after self-admin0.90.91.5-0.61.0-1.1-0.9-1.00.9-1.01.21.01.0-0.7-0.6
Diff in mean of infusions in LGA sessions1.21.31.91.1-1.21.31.21.2-1.11.2-1.4-1.2-1.20.90.8
Delay discount exponential model param1.21.32.31.3-1.21.31.21.2-1.01.1-1.5-1.2-1.20.70.6
Extinction: sum of active levers before priming0.40.42.00.8-0.50.70.60.5-0.30.5-1.4-0.6-0.6-0.0-0.1
Active lever presses in extinction session 63.02.93.41.4-1.81.81.71.8-1.71.8-1.8-1.8-1.81.51.4
Bone: final force0.40.62.9-1.10.7-0.8-0.7-0.70.4-0.71.70.40.4-0.10.1
Bone: final moment0.30.52.3-1.00.6-0.7-0.6-0.60.3-0.61.50.30.3-0.00.2
Food consumed during 24 hour testing period0.50.60.7-0.80.8-0.8-0.8-0.80.7-0.80.80.80.8-0.6-0.6
Glucose1.21.72.1-1.31.3-1.4-1.4-1.41.3-1.31.31.41.4-1.2-1.1
Heart weight0.10.20.80.4-0.40.50.30.4-0.30.3-0.9-0.3-0.30.0-0.1
Delay discount hyperbolic model param1.81.93.31.6-1.41.51.41.4-1.21.3-1.8-1.4-1.40.90.7
Intermittent access intake day 1-15 change5.15.08.93.0-2.22.32.52.2-2.02.2-2.8-2.2-2.21.61.3
Intermittent access intake escalation3.43.38.72.8-1.71.82.01.7-1.31.6-3.0-1.7-1.70.80.4
Intermittent access intake escalation 24.54.410.22.8-2.12.22.22.1-1.72.0-3.2-2.1-2.11.10.7
Intermitt. access day 1 inactive lever presses0.10.20.70.7-0.30.30.30.3-0.00.2-0.9-0.3-0.3-0.1-0.3
Intermitt. access day 15 inactive lever presses0.20.21.51.2-0.20.30.50.2-0.10.3-0.8-0.2-0.2-0.0-0.1
Intermitt. access escalation Index0.30.20.9-0.6-0.20.20.10.2-0.50.30.7-0.2-0.20.70.9
Intermittent access day 1 total infusions0.00.10.1-0.10.3-0.3-0.1-0.30.2-0.30.20.30.3-0.2-0.0
Intermittent access day 15 total infusions0.91.02.91.6-0.90.91.20.9-0.70.9-1.7-0.9-0.90.40.3
Intermittent access terminal intake (last 3 days)0.80.91.60.7-1.01.01.01.0-1.01.0-1.3-1.0-1.00.80.8
Intermittent access total infusions0.10.10.40.7-0.10.10.40.1-0.10.1-0.6-0.1-0.1-0.0-0.0
Intermittent access day 1 locomotion0.10.20.80.9-0.20.20.50.2-0.20.2-0.7-0.2-0.20.00.0
Intermittent access day 15 total locomotion2.32.55.62.4-1.51.51.81.5-1.31.5-2.2-1.5-1.51.00.8
Intermittent access total locomotion0.80.92.11.5-0.90.91.20.9-0.90.9-1.2-0.9-0.90.70.6
Intermittent access standard deviation2.12.24.51.6-1.51.61.51.5-1.31.4-2.1-1.5-1.51.00.8
Left kidney weight0.20.71.4-0.2-0.90.80.70.8-1.00.8-0.0-0.8-0.81.11.2
Right kidney weight1.64.55.31.8-2.22.32.12.2-2.12.2-1.9-2.3-2.32.01.8
Cocaine induced anxiety1.71.92.70.8-1.51.41.21.5-1.61.5-0.6-1.5-1.51.61.7
Post-drug Anxiety1.71.93.5-0.1-1.51.41.01.5-1.61.4-0.3-1.5-1.51.81.9
Baseline Anxiety0.10.10.2-0.30.2-0.1-0.1-0.20.3-0.2-0.20.20.2-0.4-0.4
Tail length2.26.711.03.2-2.62.82.72.7-2.32.6-3.3-2.5-2.51.81.5
Length with tail1.96.814.83.8-2.62.62.82.7-2.42.5-2.6-2.3-2.32.21.9
Length without tail0.40.83.31.8-0.60.51.00.7-0.80.7-0.0-0.6-0.61.01.0
Times rat made contact with spout0.40.50.9-0.50.7-0.7-0.8-0.80.8-0.70.30.40.4-0.9-1.0
Lifetime Intake0.00.00.10.1-0.10.10.30.1-0.20.1-0.4-0.1-0.10.10.2
Liver weight, left2.74.35.4-2.32.2-2.1-2.3-2.12.1-2.21.81.91.9-2.0-1.8
Liver weight, right1.42.33.1-1.81.6-1.6-1.6-1.51.4-1.51.71.51.5-1.2-1.0
Locomotor activity4.67.410.43.2-2.72.63.02.7-2.72.7-2.0-2.8-2.82.62.5
Locomotor testing distance2.44.05.52.3-2.02.02.22.0-2.02.0-1.7-1.9-1.91.91.8
Locomotor testing rearing0.00.00.1-0.10.00.10.00.00.0-0.0-0.30.10.1-0.1-0.1
Locomotion in novel chamber0.30.40.7-0.0-0.90.70.30.5-0.60.6-0.8-0.7-0.70.40.3
Locomotion in novel chamber post-restriction0.60.81.00.6-0.81.00.91.0-0.90.9-0.9-1.0-1.00.80.8
Fecal boli incidents, locomotor time 12.83.04.0-2.01.6-1.6-1.7-1.71.7-1.81.21.91.9-1.8-1.7
Change in fecal boli incidents, locomotor task1.21.12.10.7-0.91.01.01.2-1.21.1-0.3-1.1-1.11.41.4
Time >=10cm from walls, locomotor time 10.10.10.5-0.30.1-0.3-0.1-0.2-0.1-0.10.70.30.30.30.4
Bouts of movement, locomotor time 10.10.10.20.5-0.40.30.30.3-0.30.3-0.5-0.2-0.20.20.2
Total resting periods, locomotor time 10.20.20.30.6-0.50.50.50.4-0.50.4-0.5-0.4-0.40.40.4
Rest time, locomotor task time 10.30.30.60.8-0.60.50.50.5-0.60.5-0.4-0.4-0.40.60.6
Distance moved, locomotor task time 10.10.10.7-0.10.2-0.3-0.1-0.20.0-0.10.80.00.00.30.4
Vertical activity count, locomotor time 10.10.10.20.20.3-0.3-0.3-0.30.4-0.30.20.20.2-0.4-0.5
Time >=10cm from walls, locomotor time 21.51.51.9-1.01.4-1.4-1.2-1.41.4-1.30.91.21.2-1.3-1.2
Bouts of movement, locomotor time 20.91.01.60.7-1.01.01.01.0-1.11.0-0.4-0.9-0.91.21.3
Total resting periods, locomotor time 21.01.01.90.6-1.10.91.01.0-1.21.1-0.3-0.9-0.91.31.4
Rest time, locomotor task time 20.91.01.50.8-1.10.91.00.9-1.21.0-0.6-1.0-1.01.11.2
Distance moved, locomotor task time 21.21.41.9-0.51.4-1.3-1.1-1.31.4-1.30.81.21.2-1.3-1.3
Vertical activity count, locomotor time 21.71.82.9-0.61.5-1.3-1.3-1.31.6-1.40.61.41.4-1.6-1.7
Light reinforcement 15.39.714.43.8-3.23.23.53.1-3.03.2-3.1-3.1-3.12.72.3
Light reinforcement 21.82.35.22.3-1.51.51.71.5-1.41.5-1.5-1.5-1.51.21.1
Bone: marrow area0.10.10.7-0.50.3-0.3-0.2-0.20.1-0.30.80.20.20.10.2
Bone: maximum diameter1.52.84.01.3-1.61.61.71.7-1.81.6-0.7-1.9-1.91.92.0
Bone: maximum force0.50.93.0-1.30.9-1.0-0.9-0.90.7-0.91.70.60.6-0.4-0.1
Bone: maximum moment0.40.72.5-1.20.8-0.9-0.8-0.80.6-0.81.60.60.6-0.3-0.1
Mean time between licks in bursts2.73.86.42.4-2.02.12.12.1-1.71.9-2.5-1.8-1.81.31.1
Mean num. licks in bursts0.00.00.1-0.0-0.20.20.00.1-0.30.20.20.20.20.40.4
Cd content in liver0.10.10.2-0.40.3-0.4-0.3-0.30.3-0.30.50.10.1-0.2-0.2
Co content in liver0.40.40.90.9-0.50.60.60.5-0.40.5-0.9-0.9-0.90.20.0
Cu content in liver0.10.20.60.1-0.20.20.30.2-0.40.30.5-0.3-0.30.60.7
Fe content in liver0.10.10.2-0.10.2-0.1-0.2-0.20.3-0.2-0.20.10.1-0.4-0.5
K content in liver0.30.30.80.2-0.50.40.50.5-0.70.60.2-0.3-0.30.90.9
Mg content in liver0.50.51.40.1-0.60.50.60.6-0.80.70.2-0.5-0.51.01.2
Mn content in liver3.33.77.21.1-2.01.91.92.0-2.32.0-0.5-1.6-1.62.52.7
Na content in liver0.50.51.4-0.80.7-0.8-0.7-0.70.5-0.61.20.80.8-0.2-0.1
Rb content in liver0.20.20.8-0.6-0.0-0.1-0.00.0-0.30.10.90.10.10.60.8
Se content in liver0.20.30.30.5-0.50.50.50.5-0.60.6-0.4-0.4-0.40.60.5
Sr content in liver0.30.31.0-0.10.5-0.4-0.5-0.50.7-0.5-0.30.40.4-0.9-1.0
Zn content in liver0.70.73.51.3-0.60.80.60.6-0.30.6-1.9-0.7-0.7-0.2-0.5
Bone: minimum diameter0.10.20.70.1-0.40.30.40.4-0.60.40.3-0.5-0.50.70.9
Time in familiar zone, hab. session 11.41.32.41.4-1.21.31.21.2-1.01.2-1.5-1.1-1.10.80.6
Time in novel zone, hab. session 10.30.31.5-0.90.5-0.6-0.4-0.50.2-0.41.20.10.10.10.3
Total zone transitions, hab. session 11.62.33.41.2-1.61.51.51.6-1.71.7-0.7-1.2-1.21.91.9
Total locomotion distance, hab. session 12.84.06.91.4-2.11.92.02.0-2.32.1-0.6-1.7-1.72.52.6
Locomotion velocity, hab. session 12.84.05.81.6-2.12.02.02.1-2.32.2-1.0-1.8-1.82.42.4
Time in familiar zone, hab. session 24.14.28.02.5-2.12.22.12.1-1.72.0-2.8-2.1-2.11.30.9
Time in novel zone, hab. session 22.62.65.9-2.11.6-1.7-1.6-1.61.2-1.52.41.61.6-0.8-0.5
Total zone transitions, hab. session 20.30.41.3-0.2-0.40.20.30.2-0.60.40.90.50.51.01.1
Total locomotion distance, hab. session 21.41.83.01.2-1.61.41.41.4-1.61.6-0.7-0.7-0.71.71.7
Locomotion velocity, hab. session 21.62.13.71.2-1.71.51.51.5-1.81.7-0.6-0.8-0.81.91.9
Novel to familiar place preference ratio1.91.95.1-1.91.3-1.4-1.3-1.30.9-1.22.21.51.5-0.5-0.1
Novelty place preference1.01.03.0-1.40.9-1.0-0.9-0.90.6-0.81.71.11.1-0.20.1
Time in novel zone, NPP test1.21.23.4-1.51.0-1.2-1.0-1.00.7-0.91.81.21.2-0.3-0.1
Total zone transitions, NPP test0.10.10.4-0.0-0.30.20.20.2-0.40.30.40.40.40.60.6
Total locomotion distance, NPP test0.20.30.9-0.0-0.50.30.30.3-0.60.50.50.10.10.91.0
Locomotion velocity, NPP test0.30.41.20.3-0.70.60.60.6-0.90.70.2-0.1-0.11.01.1
Intraocular pressure0.20.31.0-0.60.3-0.2-0.6-0.40.6-0.5-0.50.40.4-0.9-1.0
Delta distance traveled before/after self-admin1.51.72.81.7-1.41.31.41.3-1.21.3-1.3-1.3-1.31.10.9
Delta ambulatory time before/after self-admin2.02.22.61.2-1.61.61.51.5-1.61.5-1.3-1.5-1.51.41.4
Parametrial fat weight0.40.72.81.7-0.70.70.80.7-0.60.7-1.1-0.9-0.90.40.3
Pavlov. Cond. lever latency0.20.31.0-0.10.5-0.4-0.5-0.50.7-0.5-0.30.40.4-0.9-1.0
Pavlov. Cond. magazine entry latency1.92.53.71.9-1.71.71.71.7-1.51.6-1.9-1.4-1.41.21.0
Pavlov. Cond. change in total contacts0.10.10.20.4-0.30.30.30.3-0.30.3-0.2-0.0-0.00.30.3
Pavlov. Cond. index score0.60.81.20.8-1.00.91.00.9-1.01.0-0.5-0.7-0.71.11.1
Pavlov. Cond. latency score0.91.11.90.8-1.11.01.11.1-1.21.1-0.4-0.8-0.81.31.4
Pavlov. Cond. lever contacts0.60.81.90.3-0.80.70.80.8-1.00.90.1-0.8-0.81.21.4
Pavlov. Cond. magazine entry number0.50.60.9-0.90.8-0.8-0.8-0.80.8-0.80.80.60.6-0.7-0.6
Pavlov. Cond. intertrial magazine entries0.10.10.40.20.1-0.1-0.2-0.10.3-0.2-0.4-0.0-0.0-0.5-0.6
Pavlov. Cond. lever-magazine prob. diff.1.01.31.61.1-1.21.21.21.2-1.21.2-0.8-0.9-0.91.21.2
Pavlov. Cond. response bias0.91.11.31.2-1.11.11.11.1-1.11.1-1.1-1.0-1.01.00.9
Pavlov. Cond. lever latency1.01.41.7-1.21.2-1.2-1.1-1.21.1-1.21.11.31.3-1.0-0.9
Pavlov. Cond. magazine entry latency0.80.91.30.9-0.91.01.01.0-1.00.9-0.8-1.2-1.20.90.9
Pavlov. Cond. change in total contacts0.81.21.61.2-1.11.11.01.1-1.01.1-1.2-1.3-1.30.80.7
Pavlov. Cond. index score1.11.41.91.2-1.11.21.11.2-1.11.1-1.2-1.4-1.41.00.9
Pavlov. Cond. latency score1.21.42.11.2-1.11.21.21.2-1.21.2-1.1-1.4-1.41.11.0
Pavlov. Cond. lever contacts0.70.91.41.1-1.01.00.91.0-0.80.9-1.2-1.0-1.00.70.5
Pavlov. Cond. magazine entry number1.31.51.9-1.21.2-1.3-1.3-1.31.3-1.21.01.41.4-1.2-1.2
Pavlov. Cond. intertrial magazine entries1.01.32.0-0.91.1-1.1-0.9-1.21.2-1.10.71.41.4-1.2-1.2
Pavlov. Cond. lever-magazine prob. diff.1.21.52.01.2-1.21.31.21.3-1.21.2-1.2-1.4-1.41.11.0
Pavlov. Cond. response bias1.62.13.21.7-1.51.61.41.5-1.31.4-1.8-1.6-1.61.10.9
Time in closed arm before self-admin0.20.31.5-0.30.4-0.6-0.3-0.50.2-0.41.20.50.50.10.2
Time in closed arm after self-admin0.00.00.0-0.2-0.20.2-0.10.1-0.10.1-0.1-0.1-0.10.0-0.1
Time in open arm before self-admin0.70.81.50.9-0.91.00.90.9-0.80.9-1.2-1.0-1.00.60.4
Time in open arm after self-admin0.90.91.4-0.31.2-1.1-0.8-1.11.1-1.00.81.01.0-1.0-0.9
Bone: periosteal estimation0.10.21.4-0.50.1-0.2-0.0-0.0-0.2-0.01.2-0.2-0.20.50.8
Bone: periosteal perimeter0.61.12.30.5-0.90.81.01.0-1.10.90.1-1.2-1.21.31.5
Bone: post-yield work0.60.81.0-1.01.0-1.0-0.9-0.90.9-0.91.00.70.7-0.8-0.7
Progressive ratio test 1 active lever presses0.30.30.5-0.20.7-0.6-0.5-0.70.6-0.60.20.70.7-0.7-0.6
Progressive ratio test 1 breakpoint0.30.40.4-0.50.7-0.7-0.6-0.70.6-0.60.30.70.7-0.6-0.5
Progressive ratio test 1 inactive lever presses0.00.00.10.4-0.0-0.00.10.0-0.00.0-0.1-0.0-0.00.00.0
Progressive ratio test 2 active lever presses0.10.10.5-0.0-0.20.20.20.2-0.10.2-0.7-0.2-0.2-0.0-0.0
Progressive ratio test 2 breakpoint0.20.30.5-0.0-0.60.60.50.6-0.60.5-0.7-0.6-0.60.40.5
Progressive ratio test 2 inactive lever presses0.10.10.10.3-0.20.20.30.2-0.30.3-0.3-0.2-0.20.30.3
Incentive Sensitization - Responses0.20.20.6-0.5-0.40.50.20.4-0.30.4-0.8-0.4-0.40.10.1
Incentive Sensitization - Breakpoint0.30.30.6-0.6-0.60.60.30.6-0.50.5-0.8-0.6-0.60.30.3
Sum of active levers in priming session hrs 5-60.00.00.0-0.00.2-0.1-0.1-0.20.1-0.2-0.10.10.1-0.2-0.2
Progressive ratio0.40.41.4-1.20.6-0.5-0.9-0.50.6-0.60.30.50.5-0.7-0.7
Food seeking constrained by brief footshock0.10.10.2-0.2-0.40.30.20.3-0.30.4-0.3-0.5-0.50.30.2
Seeking ratio, punishment vs. effort0.20.20.90.9-0.40.30.60.3-0.40.4-0.3-0.4-0.40.40.4
Retroperitoneal fat weight0.72.33.30.01.7-1.6-1.2-1.61.7-1.61.11.81.8-1.6-1.6
Reaction time number correct1.31.92.5-1.51.3-1.3-1.4-1.41.5-1.40.61.41.4-1.6-1.6
Reaction time mean minus median0.91.21.60.6-1.31.31.01.2-1.21.1-1.0-1.0-1.01.01.1
Reaction time mean minus median AUC0.60.82.3-0.1-0.90.80.70.9-1.20.80.1-0.5-0.51.31.5
Reaction time num false alarms0.10.20.5-0.70.4-0.3-0.4-0.30.4-0.30.10.40.4-0.4-0.5
Reaction time num false alarms AUC0.40.51.2-1.10.7-0.5-0.7-0.60.7-0.60.10.70.7-0.8-0.8
Reaction time trials correct on left1.31.92.5-1.51.3-1.3-1.4-1.41.5-1.40.61.41.4-1.6-1.6
Reaction time trials on left1.31.82.3-1.51.3-1.2-1.3-1.31.4-1.30.61.31.3-1.5-1.5
Reaction time mean0.30.41.1-0.3-0.60.50.40.6-0.80.50.3-0.4-0.40.91.1
Reaction time mean AUC0.20.30.9-0.1-0.40.40.40.4-0.60.40.4-0.3-0.30.70.9
Median of all reaction times0.10.10.7-0.6-0.0-0.1-0.1-0.0-0.2-0.00.80.10.10.40.6
Reaction time omissions0.30.40.60.5-0.70.70.70.7-0.70.7-0.5-0.5-0.50.70.7
Reaction time false alarm rate0.00.00.2-0.40.00.0-0.00.1-0.10.00.10.10.10.10.1
Reaction time premature initiation rate0.40.52.61.6-0.60.60.80.6-0.30.5-1.3-0.4-0.40.1-0.2
Reaction time premature initiations0.20.31.10.90.10.00.1-0.10.4-0.1-1.10.30.3-0.7-1.0
Std. dev. reaction times0.50.71.4-0.0-1.01.00.81.0-1.10.9-0.5-0.6-0.61.01.2
Reaction time trials completed1.31.82.3-1.51.3-1.2-1.3-1.31.4-1.30.61.31.3-1.5-1.5
Reaction time trials AUC1.42.02.8-1.51.4-1.3-1.4-1.41.5-1.40.51.41.4-1.6-1.7
Run reversals in cocaine runway, females1.21.21.70.2-1.31.20.81.1-1.21.2-0.5-1.3-1.31.31.2
Run reversals in cocaine runway, males1.81.72.30.6-1.41.41.11.4-1.41.4-1.0-1.5-1.51.41.4
Latency to leave start box in cocaine runway2.22.43.61.4-1.61.51.71.5-1.81.5-0.8-1.5-1.51.81.9
Latency to leave start box in cocaine runway, F0.91.03.20.1-0.90.70.90.8-1.30.90.4-0.9-0.91.51.8
Latency to leave start box in cocaine runway, M1.51.43.81.6-1.21.41.21.2-0.91.1-1.9-1.1-1.10.50.3
Std. dev. time between licks in bursts1.51.82.31.1-1.31.31.41.3-1.41.4-0.7-1.4-1.41.51.5
Total sessions with >9 infusions0.30.30.9-0.7-0.50.50.30.5-0.70.50.1-0.5-0.50.71.0
Short access day 1 total inactive lever presses0.00.00.00.1-0.10.10.10.1-0.10.1-0.2-0.1-0.10.10.1
Short access day 10 total inactive lever presses0.10.10.70.80.2-0.1-0.0-0.20.3-0.2-0.40.20.2-0.4-0.5
Short access day 1 total infusions0.50.51.3-0.0-0.70.70.60.7-0.90.7-0.2-0.7-0.70.91.2
Short access day 10 total infusions0.10.10.7-0.80.00.0-0.0-0.0-0.1-0.0-0.20.00.0-0.00.2
Short access total infusions0.20.20.9-1.0-0.30.30.10.3-0.50.3-0.0-0.3-0.30.50.7
Short access day 1 locomotion1.21.34.72.2-0.90.91.40.9-1.01.0-0.9-0.9-0.91.01.0
Short access day 10 total locomotion2.83.16.32.5-1.71.82.01.7-1.51.7-2.4-1.7-1.71.10.9
Short access total locomotion1.01.01.51.2-1.00.91.11.0-1.01.0-1.1-1.0-1.00.90.9
One hour access (0.3 mA shock)0.30.30.50.10.7-0.7-0.4-0.70.6-0.60.40.70.7-0.6-0.5
Compulsive drug intake0.50.51.4-0.30.7-0.8-0.7-0.70.7-0.71.20.70.7-0.4-0.5
One hour access (shock baseline)0.10.10.20.40.3-0.30.0-0.30.3-0.3-0.40.30.3-0.5-0.5
Social response proportion0.80.91.10.7-1.01.00.81.1-1.01.0-0.7-0.9-0.91.01.0
Social responses8.711.213.12.9-3.53.63.43.6-3.53.5-3.0-3.3-3.33.33.1
Social time0.91.22.0-0.71.2-1.2-1.0-1.11.1-1.10.91.41.4-1.0-1.0
Soleus weight7.722.729.5-5.45.0-5.1-5.0-4.94.6-4.95.24.54.5-4.1-3.6
Bone: stiffness1.72.86.1-2.11.7-1.9-1.8-1.81.5-1.72.51.11.1-1.1-0.9
Tibialis anterior weight0.72.43.8-2.01.7-1.7-1.7-1.61.6-1.71.81.01.0-1.4-1.2
Time to tail flick, vehicle, before self-admin1.71.83.10.2-1.41.41.21.4-1.61.4-0.5-1.3-1.31.61.8
Time to tail flick, vehicle, after self-admin0.10.10.4-0.70.10.0-0.4-0.10.3-0.2-0.40.10.1-0.5-0.6
Time to tail flick, test, before self-admin1.00.92.2-0.5-0.90.90.71.0-1.21.0-0.1-0.9-0.91.31.5
Time to tail flick, test, after self-admin0.60.61.2-0.5-0.80.80.60.8-0.90.8-0.3-0.7-0.70.91.1
Delta time to tail flick, vehicle, before/after SA1.81.83.2-1.01.3-1.2-1.4-1.31.5-1.40.41.31.3-1.7-1.8
Delta time to tail flick, test, before/after SA0.10.10.40.50.1-0.1-0.0-0.10.3-0.2-0.50.10.1-0.5-0.6
Tibia length0.72.03.31.8-1.31.41.51.4-1.21.3-1.8-1.5-1.51.00.8
Ambulatory time before self-admin0.10.10.6-0.80.3-0.3-0.4-0.30.3-0.30.40.40.4-0.2-0.1
Ambulatory time after self-admin0.60.70.80.8-0.90.90.70.8-0.80.8-0.7-0.8-0.80.80.7
Bone: tissue strength1.41.42.1-1.31.2-1.2-1.1-1.11.0-1.21.51.41.4-0.8-0.6
Total heroin consumption1.92.22.71.0-1.61.61.41.6-1.61.6-1.5-1.6-1.61.41.4
Bone: trabecular number2.23.44.61.4-1.91.71.81.8-2.01.8-0.7-2.1-2.12.12.2
Bone: trabecular spacing2.63.36.2-1.11.7-1.6-1.7-1.72.0-1.80.12.02.0-2.3-2.5
Bone: trabecular thickness2.73.38.10.7-1.61.41.61.6-2.11.70.7-1.9-1.92.52.8
Bone: trabecular tissue density3.44.85.6-2.02.4-2.2-2.2-2.22.3-2.31.62.22.2-2.3-2.2
Water consumed over 24 hours0.10.21.0-0.60.3-0.4-0.3-0.30.1-0.21.0-0.1-0.10.20.4
Number of responses in last shaping day0.20.20.40.6-0.40.40.50.4-0.40.4-0.4-0.4-0.40.40.4