Hub : Genes

Sectm1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Sectm1a	0.08	0.04	2.0e-06	0.05	0.05	0.06	0.06	1.7e-06	1.5e-06	3.2e-07	9.7e-07
2	Brain	gene expression	Sectm1a	0.06	0.06	4.7e-03	0.01	0.01	0.01	0.01	2.6e-02	3.2e-02	8.2e-02	5.2e-02
3	BLA	gene expression	Sectm1a	0.13	0.07	3.1e-05	0.1	0.1	0.09	0.1	3.9e-06	8.7e-06	1.4e-05	4.8e-06
4	NAcc	gene expression	Sectm1a	0.03	0.02	6.9e-03	0.01	0.01	0.01	0.01	4.7e-02	6.3e-03	5.0e-02	5.0e-02
5	Liver	isoform ratio	XM_006247885.4	0.04	0.03	4.3e-03	0.02	0.02	0.02	0.02	1.2e-03	4.9e-03	2.0e-03	1.0e-03
6	Liver	isoform ratio	NM_001013043.1	0.04	0.03	7.6e-03	0.02	0.01	0.02	0.02	1.5e-03	8.0e-03	1.9e-03	1.1e-03
7	Liver	gene expression	Sectm1a	0.15	0.08	3.9e-12	0.06	0.1	0.1	0.1	3.2e-07	9.9e-12	2.2e-11	3.7e-11
8	Adipose	gene expression	Sectm1a	0.26	0.13	1.6e-08	0.06	0.06	0.06	0.05	5.7e-07	1.4e-07	7.4e-07	1.6e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bone: apparent density	0.2	0.3	0.7	-0.3	-0.2	-0.2	0.5	-0.8	0.8	0.6	0.8
Area under the delay curve	0.2	0.2	0.4	-0.3	0.3	0.5	0.6	0.6	-0.6	0.2	0.2
BMI with tail	0.5	1.8	5.2	1.4	2.0	2.3	0.7	-0.9	0.9	0.5	0.7
BMI without tail	3.3	6.8	15.0	-1.3	-2.6	-2.2	1.4	-3.9	3.9	2.8	1.4
Body weight	0.7	2.8	6.6	2.6	1.8	2.2	-0.4	-2.0	2.0	0.2	-0.1
Weight adjusted by age	0.6	0.7	2.0	1.4	0.6	1.0	-1.1	-0.1	0.1	-0.8	-0.8
Bone surface	0.2	0.3	0.8	-0.3	-0.9	-0.9	-0.2	-0.6	0.6	0.0	0.2
Bone volume	0.2	0.3	0.5	-0.3	-0.7	-0.7	0.0	-0.7	0.7	0.3	0.4
Breakpoint value in progressive ratio session	1.6	1.7	3.3	1.6	1.1	1.1	-1.4	1.1	-1.1	-1.1	-1.8
Number of licking bursts	0.6	0.7	1.1	-0.8	-0.5	-1.1	0.7	-0.9	0.9	0.8	1.0
Context. condit. distance diff. score	2.7	3.3	5.0	-1.7	-1.9	-1.4	1.5	-2.2	2.2	1.9	1.5
Locomotion velocity, session 1	1.9	2.1	3.7	0.9	1.3	1.4	-1.1	1.9	-1.9	-1.6	-1.2
Locomotion distance, session 1	0.9	1.2	3.5	-1.0	0.1	0.3	1.9	-0.2	0.2	1.1	1.8
Locomotion velocity, session 2	0.7	0.8	2.4	-0.2	0.7	0.7	0.5	1.5	-1.5	-0.3	0.3
Locomotion distance, session 2	0.8	1.1	2.5	-0.8	-0.3	0.0	1.6	-0.8	0.8	1.2	1.6
Locomotion velocity, session 3	1.1	1.3	2.4	0.7	1.3	1.5	-0.2	1.6	-1.6	-0.8	-0.3
Locomotion distance, session 3	0.7	0.7	1.6	0.1	1.0	1.3	0.7	1.1	-1.1	-0.0	0.5
Stereotopy head waving bouts, day 3	0.7	0.8	1.7	0.6	1.1	1.3	-0.4	1.1	-1.1	-0.9	-0.3
Stereotopy head waving duration, day 3	0.3	0.3	0.9	0.4	0.9	0.9	-0.0	0.6	-0.6	-0.5	0.1
Locomotion velocity, session 7	0.2	0.2	0.4	-0.7	-0.2	-0.3	0.6	0.2	-0.2	0.4	0.6
Locomotion distance, session 7	1.6	2.0	4.3	-2.0	-0.9	-0.8	2.1	-0.6	0.6	1.7	1.7
Stereotopy head waving bouts, day 7	0.1	0.1	0.5	0.4	0.7	0.5	0.0	-0.1	0.1	-0.1	0.3
Stereotopy head waving duration, day 7	0.1	0.1	0.4	0.6	0.6	0.4	-0.3	-0.0	0.0	-0.3	0.1
Locomotion velocity, session 8	1.1	1.3	3.2	-0.8	0.2	0.1	1.8	-1.0	1.0	1.4	1.6
Locomotion distance, session 8	4.4	6.4	8.7	-2.2	-1.9	-1.2	2.9	-2.9	2.9	2.9	2.9
Degree of sensitization distance	1.7	1.7	3.1	-1.4	-1.8	-1.7	0.5	-1.5	1.5	1.1	0.5
Degree of sensitization stereotypy	0.1	0.1	0.2	0.4	0.4	0.3	0.1	-0.4	0.4	0.1	0.2
Conditioned locomotion	1.6	1.9	4.8	-0.5	-1.5	-1.3	0.4	-2.2	2.2	1.1	0.6
Cocaine response after cond. corrected	0.4	0.5	1.0	0.7	1.0	0.4	-0.6	0.6	-0.6	-0.6	-0.8
Cocaine response after cond. not corrected	0.3	0.3	0.5	0.4	0.7	0.3	-0.2	0.7	-0.7	-0.3	-0.5
Cocaine response before conditioning	0.5	0.6	1.4	-0.8	-0.8	-0.1	1.2	0.0	-0.0	0.8	1.2
Saline control response	0.5	0.6	1.3	0.3	-1.1	-1.0	-0.4	-1.1	1.1	0.3	-0.2
Bone: connectivity density	0.8	1.3	1.8	-1.2	-1.0	-1.0	1.1	-1.1	1.1	1.2	1.3
Bone: cortical apparent density	0.5	0.6	1.9	-0.1	0.8	0.6	0.1	1.4	-1.4	-0.4	-0.1
Bone: cortical area	3.7	5.5	15.7	3.8	3.4	4.0	-0.9	-0.6	0.6	-1.0	-0.2
Bone: cortical porosity	4.7	5.1	7.0	2.5	2.1	1.6	-2.6	2.0	-2.0	-2.5	-2.5
Bone: cortical porosity	3.3	3.6	5.4	2.2	1.7	1.3	-2.3	1.5	-1.5	-2.1	-2.1
Bone: cortical thickness	6.8	11.2	32.3	5.0	5.1	5.7	-1.4	0.3	-0.3	-1.9	-0.8
Bone: cortical thickness	3.9	4.5	14.3	2.9	3.8	3.5	-0.6	0.2	-0.2	-1.0	-0.3
Bone: cortical tissue density	0.5	0.6	2.1	-0.2	0.6	0.4	0.1	1.5	-1.5	-0.5	-0.1
Condit. Reinf. active minus inactive responses	0.4	0.5	1.6	0.2	-0.2	-0.5	-0.3	-1.3	1.3	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.5	0.6	0.1	-0.2	-0.7	0.7	0.0	0.0
Condit. Reinf. active responses	1.0	1.2	3.6	0.0	-0.9	-1.0	-0.3	-1.9	1.9	0.5	-0.1
Condit. Reinf. inactive responses	0.6	0.7	1.8	-0.4	-1.4	-1.1	-0.2	-1.1	1.1	0.4	-0.2
Incentive salience index mean	0.6	0.7	2.0	-0.1	-0.7	-0.9	0.0	-1.4	1.4	0.5	0.2
Condit. Reinf. lever presses	0.8	1.1	1.8	-1.1	-1.2	-1.3	0.9	-0.9	0.9	1.0	0.9
Condit. Reinf. active minus inactive responses	0.2	0.3	0.6	0.5	0.6	0.8	0.0	-0.7	0.7	0.1	-0.0
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.4	1.2	1.1	0.8	-0.9	-0.4	0.4	-0.7	-0.8
Condit. Reinf. active responses	0.1	0.2	0.6	-0.0	0.2	0.3	0.4	-0.7	0.7	0.4	0.1
Condit. Reinf. inactive responses	0.1	0.2	0.5	-0.5	-0.2	0.1	0.7	-0.1	0.1	0.5	0.4
Condit. Reinf. lever presses	0.4	0.5	1.0	-0.6	-0.5	-0.5	0.7	-1.0	1.0	0.8	0.6
Condit. Reinf. lever reinforcers received	0.2	0.3	0.9	-0.3	-0.0	0.0	0.6	-1.0	1.0	0.7	0.3
Conditioned reinforcement - actives	0.7	0.7	1.3	-0.9	-0.6	-0.7	0.9	-0.8	0.8	0.9	1.1
Conditioned reinforcement - inactives	0.3	0.3	0.8	0.7	0.2	-0.1	-0.6	-0.7	0.7	-0.1	-0.9
Conditioned locomotion	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.3	-0.5	0.5	0.3	0.5
Patch foraging indifference point 0 sec	0.0	0.1	0.2	0.1	-0.4	-0.3	-0.2	-0.3	0.3	0.1	-0.1
Patch foraging indifference point AUC	0.2	0.3	0.7	-0.5	-0.4	-0.5	0.1	-0.8	0.8	0.2	0.1
Delay disc. indifference point, 0s delay	0.2	0.2	0.8	0.5	0.9	0.9	0.3	0.1	-0.1	-0.1	0.3
Delay disc. indifference point, 16s delay	1.3	1.3	3.1	-1.5	-0.7	-0.4	1.8	-0.3	0.3	1.4	1.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	0.2	0.5	0.6	-0.0	0.3	-0.3	-0.3	-0.2
Delay disc. indifference point, 24s delay	1.2	1.1	3.1	0.1	1.0	1.1	-0.0	1.8	-1.8	-0.8	-0.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.3	0.6	0.6	0.3	0.4	-0.4	-0.1	0.2
Delay disc. indifference point, 8s delay	0.5	0.6	1.0	0.6	0.8	1.0	-0.2	0.9	-0.9	-0.6	-0.7
Indifference point function ln k	0.3	0.5	1.0	0.0	0.7	0.8	0.9	0.7	-0.7	0.2	1.0
Indifference point function log k	0.3	0.5	1.0	0.0	0.7	0.8	0.9	0.7	-0.7	0.2	1.0
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	0.0	-0.4	-0.2	0.0	-0.4	0.4	0.2	0.0
Patch foraging total patch changes 12 sec	0.1	0.2	0.4	0.1	-0.3	-0.3	-0.5	-0.4	0.4	-0.3	-0.6
Patch foraging total patch changes 18 sec	0.5	0.6	0.9	-0.9	-0.9	-0.7	0.7	-0.8	0.8	0.9	0.6
Patch foraging total patch changes 24 sec	0.1	0.1	0.3	0.1	-0.4	-0.3	-0.2	-0.5	0.5	0.2	-0.1
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	0.5	-0.2	-0.2	-0.7	-0.3	0.3	-0.4	-0.4
Patch foraging time to switch 0 sec	0.1	0.2	0.4	-0.3	-0.2	-0.5	0.0	0.7	-0.7	-0.1	0.0
Patch foraging water rate 0 sec	0.4	0.7	2.2	0.1	-0.7	0.0	0.2	-1.5	1.5	0.8	-0.1
Patch foraging water rate 12 sec	0.4	0.6	1.3	0.1	0.8	1.2	1.0	-0.5	0.5	0.9	0.7
Patch foraging water rate 18 sec	0.7	0.9	2.0	-0.3	-0.2	0.3	1.3	-0.9	0.9	1.3	1.4
Patch foraging water rate 24 sec	0.8	1.0	2.5	-0.3	-0.2	0.3	1.2	-1.3	1.3	1.6	1.0
Patch foraging water rate 6 sec	0.6	0.9	3.2	0.5	1.3	1.8	0.9	-0.6	0.6	0.7	0.6
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.9	0.2	-0.4	-0.5	-0.0	-1.0	1.0	0.3	0.2
Distance traveled before self-admin	1.4	1.5	3.2	1.4	0.7	0.4	-1.8	0.8	-0.8	-1.5	-1.6
Distance traveled after self-admin	1.6	1.8	6.1	-1.4	-2.5	-2.2	0.2	-0.8	0.8	0.8	0.2
Extensor digitorum longus weight	0.8	3.1	4.4	-1.5	-1.4	-1.3	1.9	-1.9	1.9	1.9	2.1
Bone: elastic displacement	0.6	0.7	2.0	1.4	1.0	0.7	-0.9	0.1	-0.1	-0.8	-0.5
Bone: elastic work	4.9	6.3	15.1	3.9	3.0	2.8	-2.7	0.6	-0.6	-2.5	-2.0
Bone: endosteal estimation	0.9	1.9	3.0	-1.5	-1.7	-1.6	1.0	-1.3	1.3	1.4	0.9
Bone: endosteal perimeter	0.2	0.3	0.9	0.0	-1.0	-0.8	-0.5	-0.6	0.6	0.0	-0.2
Epididymis fat weight	0.2	0.5	1.2	-0.1	-0.4	-0.4	0.5	-1.1	1.1	0.9	0.6
Delta time in closed arm before/after self-admin	0.4	0.4	0.7	-0.7	-0.3	-0.6	0.8	-0.5	0.5	0.8	0.7
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.0	0.1	-0.1	0.1	-0.1
Diff in mean of infusions in LGA sessions	0.6	0.6	2.3	-0.1	-0.4	-0.3	-0.3	1.5	-1.5	-0.3	-0.4
Delay discount exponential model param	0.3	0.3	0.9	0.1	-0.5	-0.7	-0.4	-0.9	0.9	0.1	0.0
Extinction: sum of active levers before priming	2.2	2.2	4.4	1.1	2.1	1.8	-0.6	1.8	-1.8	-1.2	-0.5
Active lever presses in extinction session 6	3.6	3.5	6.5	2.1	2.4	2.5	-1.2	1.7	-1.7	-1.5	-1.5
Bone: final force	2.8	4.6	11.5	3.3	3.4	3.3	-0.7	-0.9	0.9	-0.7	-0.3
Bone: final moment	3.0	4.9	12.8	3.6	3.4	3.4	-1.1	-0.8	0.8	-1.0	-0.6
Food consumed during 24 hour testing period	0.4	0.5	1.8	-0.5	-1.3	-1.2	-0.1	-0.6	0.6	0.2	0.1
Glucose	7.5	11.3	16.4	2.7	3.5	3.1	-2.7	4.1	-4.1	-3.4	-3.2
Heart weight	0.9	1.3	4.0	1.4	1.9	2.0	-0.5	-0.2	0.2	-0.7	-0.3
Delay discount hyperbolic model param	0.3	0.3	0.8	0.1	-0.5	-0.7	-0.5	-0.9	0.9	0.1	-0.1
Intermittent access intake day 1-15 change	0.8	0.8	2.2	-0.2	-1.5	-1.5	-0.7	-0.5	0.5	0.0	-0.9
Intermittent access intake escalation	1.1	1.0	3.2	-0.6	-1.8	-1.8	-0.4	-0.7	0.7	0.4	-0.6
Intermittent access intake escalation 2	1.2	1.2	4.1	0.9	-0.5	-0.5	-1.8	0.1	-0.1	-1.0	-2.0
Intermitt. access day 1 inactive lever presses	0.4	0.4	1.2	0.9	0.0	-0.0	-0.9	-0.1	0.1	-0.4	-1.1
Intermitt. access day 15 inactive lever presses	0.5	0.5	1.1	-0.4	-0.6	-0.8	0.3	-1.1	1.1	0.8	0.3
Intermitt. access escalation Index	2.2	1.9	3.1	-1.4	-1.6	-1.8	1.0	-1.4	1.4	1.4	1.1
Intermittent access day 1 total infusions	0.2	0.3	0.9	0.1	0.2	-0.2	0.2	-1.0	1.0	0.2	0.4
Intermittent access day 15 total infusions	0.7	0.8	1.7	-0.5	-1.0	-1.3	0.1	-1.2	1.2	0.6	0.1
Intermittent access terminal intake (last 3 days)	0.7	0.7	1.9	-0.3	-1.1	-1.4	-0.4	-1.1	1.1	0.2	-0.4
Intermittent access total infusions	0.5	0.5	1.2	-0.4	-0.6	-1.0	0.2	-1.1	1.1	0.5	0.3
Intermittent access day 1 locomotion	0.4	0.4	0.9	-0.1	0.2	-0.1	0.7	-1.0	1.0	0.8	0.6
Intermittent access day 15 total locomotion	0.2	0.2	0.6	0.2	-0.3	-0.3	-0.3	-0.7	0.7	-0.0	-0.3
Intermittent access total locomotion	0.2	0.2	0.9	0.2	0.0	-0.2	0.2	-0.9	0.9	0.3	0.0
Intermittent access standard deviation	2.2	2.3	3.1	1.5	1.3	1.3	-1.4	1.7	-1.7	-1.5	-1.8
Left kidney weight	0.9	2.6	8.3	2.1	2.7	2.9	-0.4	0.2	-0.2	-0.9	-0.1
Right kidney weight	0.8	2.2	7.3	1.6	2.7	2.6	0.4	-0.0	0.0	-0.4	0.5
Cocaine induced anxiety	4.7	5.4	10.4	3.1	2.1	1.7	-3.0	0.8	-0.8	-2.3	-3.2
Post-drug Anxiety	2.0	2.2	4.3	1.9	1.7	1.3	-1.6	0.6	-0.6	-1.4	-2.1
Baseline Anxiety	1.6	1.8	4.9	-1.8	-0.1	-0.0	2.2	0.3	-0.3	1.3	2.0
Tail length	2.6	7.8	16.5	-1.1	-3.5	-3.4	0.3	-4.1	4.1	2.0	0.3
Length with tail	0.3	1.0	3.1	1.8	0.5	0.4	-1.1	-1.2	1.2	-0.4	-0.8
Length without tail	4.6	10.0	20.0	3.6	4.5	4.4	-1.7	2.7	-2.7	-2.8	-1.6
Times rat made contact with spout	1.5	1.7	4.5	0.3	-1.3	-1.4	-2.1	0.3	-0.3	-1.4	-1.8
Lifetime Intake	0.3	0.3	0.6	-0.4	-0.4	-0.8	0.2	-0.7	0.7	0.4	0.3
Liver weight, left	1.5	2.3	2.9	1.6	1.5	1.4	-1.3	1.7	-1.7	-1.6	-1.3
Liver weight, right	0.2	0.3	1.0	1.0	0.7	0.2	-0.5	-0.4	0.4	-0.2	-0.3
Locomotor activity	0.1	0.2	0.7	-0.2	0.3	0.4	0.2	0.8	-0.8	-0.1	0.1
Locomotor testing distance	0.3	0.4	0.9	-0.8	-0.2	-0.2	0.9	0.6	-0.6	0.5	1.0
Locomotor testing rearing	0.5	0.8	1.9	-1.4	-1.3	-1.1	0.6	0.3	-0.3	0.7	0.4
Locomotion in novel chamber	0.1	0.1	0.4	-0.6	-0.0	0.1	0.6	0.0	-0.0	0.4	0.4
Locomotion in novel chamber post-restriction	0.6	0.7	1.6	0.1	-1.3	-0.8	-0.5	-1.3	1.3	0.2	-0.4
Fecal boli incidents, locomotor time 1	0.2	0.2	0.6	-0.8	-0.1	-0.3	0.6	-0.1	0.1	0.4	0.8
Change in fecal boli incidents, locomotor task	1.8	1.7	3.8	0.6	0.5	0.5	-1.1	2.0	-2.0	-1.3	-1.5
Time >=10cm from walls, locomotor time 1	2.6	2.6	4.2	-1.5	-1.7	-1.7	1.1	-2.0	2.0	1.6	0.9
Bouts of movement, locomotor time 1	0.3	0.3	0.8	-0.1	0.8	0.5	0.2	0.9	-0.9	-0.4	0.3
Total resting periods, locomotor time 1	0.5	0.5	1.4	0.1	0.8	0.6	-0.1	1.2	-1.2	-0.7	0.1
Rest time, locomotor task time 1	0.3	0.3	0.6	0.3	0.3	0.1	-0.7	0.8	-0.8	-0.8	-0.5
Distance moved, locomotor task time 1	0.3	0.3	0.7	-0.2	-0.6	-0.5	0.5	-0.6	0.6	0.8	0.0
Vertical activity count, locomotor time 1	0.7	0.8	1.4	-0.6	-0.8	-0.5	0.8	-1.2	1.2	1.2	0.5
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.8	0.2	0.6	0.7	0.5	-0.9	0.9	0.1	0.7
Bouts of movement, locomotor time 2	0.2	0.3	0.9	-0.6	0.2	-0.1	0.9	0.3	-0.3	0.5	0.6
Total resting periods, locomotor time 2	0.5	0.6	1.5	-0.9	-0.2	-0.5	1.2	-0.1	0.1	0.9	1.0
Rest time, locomotor task time 2	0.5	0.5	1.6	-0.8	-1.3	-1.3	0.0	0.4	-0.4	0.2	0.2
Distance moved, locomotor task time 2	0.3	0.4	1.4	0.6	1.2	1.0	0.3	-0.1	0.1	0.1	0.2
Vertical activity count, locomotor time 2	0.8	0.8	1.4	0.0	0.8	1.0	1.2	-0.9	0.9	1.0	1.0
Light reinforcement 1	1.0	1.9	2.7	-1.2	-1.5	-1.7	0.9	-1.5	1.5	1.4	1.1
Light reinforcement 2	0.4	0.5	1.5	-0.1	-0.3	-0.5	0.2	-1.2	1.2	0.7	0.4
Bone: marrow area	0.8	1.7	2.8	-1.5	-1.7	-1.5	1.0	-1.2	1.2	1.3	0.9
Bone: maximum diameter	0.5	0.9	2.7	1.6	1.1	1.6	-0.2	-0.5	0.5	-0.2	0.2
Bone: maximum force	2.4	4.1	10.0	3.1	3.1	3.2	-0.6	-1.2	1.2	-0.5	-0.2
Bone: maximum moment	2.5	4.3	10.8	3.3	3.1	3.2	-0.9	-1.1	1.1	-0.8	-0.5
Mean time between licks in bursts	0.2	0.3	0.9	-0.5	0.1	0.3	0.9	0.3	-0.3	0.6	0.7
Mean num. licks in bursts	0.9	1.1	2.7	0.7	-0.4	-0.0	-1.6	0.7	-0.7	-1.3	-1.6
Cd content in liver	0.3	0.4	0.8	-0.3	0.7	0.9	0.9	0.4	-0.4	0.3	0.6
Co content in liver	0.1	0.2	0.6	-0.4	-0.8	-0.4	0.3	-0.0	0.0	0.3	0.4
Cu content in liver	1.0	1.2	2.0	1.4	0.4	0.7	-1.4	1.0	-1.0	-1.4	-1.2
Fe content in liver	0.3	0.4	1.0	-0.9	-1.0	-0.5	0.6	0.3	-0.3	0.5	0.4
K content in liver	2.5	2.5	4.2	-1.1	-2.0	-2.0	0.7	-1.9	1.9	1.3	1.0
Mg content in liver	4.2	4.3	5.7	-2.1	-2.4	-2.2	1.8	-2.1	2.1	2.2	1.8
Mn content in liver	0.1	0.2	0.5	0.6	0.4	0.7	-0.2	-0.1	0.1	-0.2	-0.1
Na content in liver	0.1	0.1	0.3	-0.1	-0.3	-0.6	-0.1	0.1	-0.1	0.0	-0.0
Rb content in liver	0.8	1.0	2.5	-0.4	-0.3	-0.3	0.8	-1.6	1.6	1.0	0.8
Se content in liver	0.6	0.7	2.2	-0.8	-1.3	-1.5	-0.0	-0.8	0.8	0.5	0.0
Sr content in liver	2.9	2.7	3.9	1.3	0.9	1.2	-1.8	1.9	-1.9	-2.0	-1.7
Zn content in liver	0.1	0.1	0.4	-0.1	-0.7	-0.3	0.1	-0.0	0.0	0.1	0.1
Bone: minimum diameter	0.6	1.1	3.7	1.9	0.8	1.3	-0.9	-0.7	0.7	-0.6	-0.2
Time in familiar zone, hab. session 1	0.6	0.6	1.0	0.7	1.0	0.8	-0.6	0.5	-0.5	-0.7	-0.8
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.5	-0.5	-0.6	0.4	-0.4	0.4	0.5	0.5
Total zone transitions, hab. session 1	0.1	0.2	0.5	-0.2	0.2	0.5	0.7	-0.0	0.0	0.4	0.7
Total locomotion distance, hab. session 1	0.4	0.5	1.5	-0.3	-0.1	-0.1	0.9	-0.8	0.8	0.7	1.2
Locomotion velocity, hab. session 1	0.4	0.6	1.6	-0.3	-0.4	-0.1	0.9	-0.8	0.8	0.7	1.3
Time in familiar zone, hab. session 2	0.2	0.2	0.6	-0.6	-0.8	-0.4	0.5	-0.2	0.2	0.5	0.4
Time in novel zone, hab. session 2	0.2	0.2	1.0	0.3	1.0	0.6	0.1	0.2	-0.2	-0.1	0.1
Total zone transitions, hab. session 2	1.8	2.4	4.5	-1.4	-0.6	-0.4	2.0	-1.5	1.5	1.8	2.1
Total locomotion distance, hab. session 2	2.7	3.6	5.2	-1.5	-1.3	-1.3	2.0	-2.2	2.2	2.1	2.3
Locomotion velocity, hab. session 2	2.5	3.3	5.1	-1.3	-1.2	-1.1	1.8	-2.3	2.3	1.9	2.2
Novel to familiar place preference ratio	1.7	1.8	3.7	1.9	1.2	1.1	-1.7	0.5	-0.5	-1.5	-1.5
Novelty place preference	1.9	1.9	3.7	1.9	1.2	1.2	-1.8	0.6	-0.6	-1.5	-1.6
Time in novel zone, NPP test	1.4	1.4	2.9	1.7	1.1	1.1	-1.5	0.4	-0.4	-1.3	-1.3
Total zone transitions, NPP test	3.2	4.5	6.7	-2.2	-1.7	-1.4	2.6	-1.9	1.9	2.4	2.6
Total locomotion distance, NPP test	3.9	5.4	7.1	-2.2	-1.8	-1.7	2.5	-2.4	2.4	2.6	2.7
Locomotion velocity, NPP test	2.7	3.9	5.0	-1.8	-1.7	-1.5	2.0	-2.1	2.1	2.1	2.2
Intraocular pressure	0.6	0.8	2.1	-0.6	-1.5	-1.0	0.3	-1.2	1.2	0.7	0.2
Delta distance traveled before/after self-admin	2.4	2.6	4.7	-2.2	-2.2	-1.9	1.5	-0.7	0.7	1.7	1.2
Delta ambulatory time before/after self-admin	2.8	3.1	6.3	-2.5	-2.4	-2.1	1.7	-0.5	0.5	1.7	1.4
Parametrial fat weight	0.4	0.8	2.3	0.4	-0.6	-0.5	-0.6	-1.5	1.5	0.0	-0.4
Pavlov. Cond. lever latency	1.5	1.9	3.9	-1.6	-0.5	-0.6	2.0	-1.0	1.0	1.8	1.7
Pavlov. Cond. magazine entry latency	1.7	2.2	5.1	1.9	0.3	0.8	-2.3	0.6	-0.6	-1.7	-2.2
Pavlov. Cond. change in total contacts	2.1	2.2	3.1	1.7	1.1	1.1	-1.7	1.3	-1.3	-1.7	-1.7
Pavlov. Cond. index score	1.1	1.4	3.7	1.5	-0.0	0.3	-1.9	0.2	-0.2	-1.4	-1.7
Pavlov. Cond. latency score	1.3	1.6	4.3	1.6	0.0	0.4	-2.1	0.5	-0.5	-1.6	-1.8
Pavlov. Cond. lever contacts	0.4	0.5	1.3	0.8	-0.2	0.1	-1.1	0.4	-0.4	-0.9	-0.9
Pavlov. Cond. magazine entry number	3.1	3.9	7.7	-2.3	-0.8	-1.3	2.8	-1.2	1.2	2.4	2.7
Pavlov. Cond. intertrial magazine entries	1.1	1.3	2.1	-1.0	-0.8	-1.2	0.9	-1.4	1.4	1.2	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	3.7	1.7	0.2	0.5	-1.9	0.2	-0.2	-1.4	-1.7
Pavlov. Cond. response bias	2.1	2.6	5.1	2.0	0.6	1.0	-2.3	0.9	-0.9	-1.9	-2.2
Pavlov. Cond. lever latency	0.9	1.2	1.8	1.1	1.1	1.1	-0.7	1.3	-1.3	-1.1	-0.8
Pavlov. Cond. magazine entry latency	1.4	1.6	3.2	-1.8	-1.2	-1.2	1.6	-0.4	0.4	1.5	1.4
Pavlov. Cond. change in total contacts	0.6	0.8	1.4	-1.2	-0.7	-0.8	1.0	-0.6	0.6	1.1	0.9
Pavlov. Cond. index score	0.8	1.0	1.8	-1.3	-1.1	-1.2	1.0	-0.7	0.7	1.1	0.9
Pavlov. Cond. latency score	1.1	1.3	2.0	-1.4	-1.1	-1.2	1.2	-0.9	0.9	1.3	1.1
Pavlov. Cond. lever contacts	1.3	1.8	2.5	-1.3	-1.5	-1.5	0.8	-1.6	1.6	1.3	0.9
Pavlov. Cond. magazine entry number	1.5	1.8	3.2	1.8	1.2	1.4	-1.7	0.6	-0.6	-1.6	-1.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	1.2	0.5	-0.1	0.3	-0.3	-1.1	1.1	0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	2.1	-1.4	-1.1	-1.3	1.1	-0.7	0.7	1.2	0.9
Pavlov. Cond. response bias	0.9	1.2	1.8	-1.3	-1.2	-1.2	1.0	-1.0	1.0	1.3	0.9
Time in closed arm before self-admin	1.0	1.2	1.6	1.2	1.1	1.3	-1.0	0.9	-0.9	-1.2	-0.9
Time in closed arm after self-admin	1.7	1.7	2.2	1.2	1.3	1.1	-1.2	1.4	-1.4	-1.4	-1.5
Time in open arm before self-admin	0.5	0.6	1.8	-0.8	-0.4	-0.5	1.0	-0.5	0.5	0.7	1.3
Time in open arm after self-admin	0.3	0.3	0.9	-0.6	-0.1	-0.0	0.8	-0.3	0.3	0.7	0.9
Bone: periosteal estimation	0.5	1.0	2.1	1.4	1.0	1.4	-0.0	-1.1	1.1	0.1	0.3
Bone: periosteal perimeter	1.8	3.1	8.1	2.9	1.9	2.4	-1.7	0.3	-0.3	-1.5	-1.2
Bone: post-yield work	0.4	0.5	0.9	-0.6	0.1	-0.2	1.0	-0.7	0.7	0.9	0.8
Progressive ratio test 1 active lever presses	0.8	0.8	1.5	-0.5	-1.1	-1.2	0.0	-1.2	1.2	0.6	0.1
Progressive ratio test 1 breakpoint	0.8	0.9	1.7	-0.4	-1.2	-1.3	-0.1	-1.3	1.3	0.5	0.0
Progressive ratio test 1 inactive lever presses	0.5	0.5	1.7	0.2	-0.4	-0.5	0.0	-1.3	1.3	0.6	0.1
Progressive ratio test 2 active lever presses	0.3	0.3	0.8	-0.2	-0.6	-0.8	-0.2	-0.9	0.9	0.2	-0.2
Progressive ratio test 2 breakpoint	0.6	0.7	1.5	-0.6	-0.8	-1.1	0.2	-1.2	1.2	0.6	0.1
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	0.5	0.3	0.0	-0.4	-0.4	0.4	-0.1	-0.6
Incentive Sensitization - Responses	0.3	0.3	0.9	-0.3	-0.6	-1.0	-0.2	-0.8	0.8	0.2	-0.2
Incentive Sensitization - Breakpoint	0.3	0.3	0.7	-0.3	-0.6	-0.9	-0.3	-0.7	0.7	0.0	-0.3
Sum of active levers in priming session hrs 5-6	1.3	1.2	3.6	1.3	0.9	0.5	-1.5	0.4	-0.4	-1.0	-1.9
Progressive ratio	0.1	0.1	0.2	-0.1	0.5	0.3	0.2	0.2	-0.2	-0.0	0.1
Food seeking constrained by brief footshock	0.3	0.3	0.8	0.3	-0.0	-0.1	-0.8	0.5	-0.5	-0.9	-0.7
Seeking ratio, punishment vs. effort	0.2	0.2	0.6	-0.2	-0.7	-0.8	-0.1	-0.5	0.5	0.1	0.1
Retroperitoneal fat weight	0.7	2.4	6.7	0.4	-1.8	-1.3	-0.8	-2.6	2.6	0.4	-0.2
Reaction time number correct	4.7	6.7	10.3	-2.7	-1.9	-1.4	3.1	-2.5	2.5	3.2	3.0
Reaction time mean minus median	0.6	0.8	1.3	0.4	-0.1	0.1	-1.1	1.1	-1.1	-1.0	-1.1
Reaction time mean minus median AUC	0.1	0.2	0.4	-0.0	0.0	-0.1	-0.4	0.6	-0.6	-0.4	-0.4
Reaction time num false alarms	0.0	0.1	0.1	-0.3	-0.3	-0.0	0.0	0.3	-0.3	-0.1	0.1
Reaction time num false alarms AUC	0.1	0.1	0.4	-0.6	-0.4	-0.2	0.4	0.3	-0.3	0.2	0.5
Reaction time trials correct on left	4.7	6.7	10.3	-2.7	-1.9	-1.4	3.1	-2.5	2.5	3.2	3.0
Reaction time trials on left	4.9	7.0	10.7	-2.7	-1.9	-1.4	3.2	-2.6	2.6	3.3	3.0
Reaction time mean	0.1	0.1	0.2	-0.2	-0.5	-0.1	-0.2	-0.4	0.4	0.0	-0.1
Reaction time mean AUC	0.2	0.3	0.5	-0.6	-0.7	-0.4	0.3	-0.7	0.7	0.5	0.5
Median of all reaction times	0.1	0.2	0.6	-0.2	-0.3	-0.0	0.2	-0.8	0.8	0.4	0.2
Reaction time omissions	0.5	0.7	1.9	-0.9	-1.4	-1.0	0.5	-0.7	0.7	0.8	0.6
Reaction time false alarm rate	0.9	1.3	2.3	0.8	0.5	0.5	-1.2	1.5	-1.5	-1.4	-1.1
Reaction time premature initiation rate	0.0	0.1	0.2	-0.5	-0.2	-0.3	0.3	0.2	-0.2	0.0	0.1
Reaction time premature initiations	1.6	2.3	3.7	-1.9	-1.2	-1.0	1.9	-1.1	1.1	1.8	1.7
Std. dev. reaction times	0.1	0.1	0.4	-0.6	-0.6	-0.1	-0.0	0.4	-0.4	-0.1	0.0
Reaction time trials completed	4.9	7.0	10.7	-2.7	-1.9	-1.4	3.2	-2.6	2.6	3.3	3.0
Reaction time trials AUC	4.8	6.9	10.3	-2.7	-1.9	-1.3	3.1	-2.6	2.6	3.2	3.0
Run reversals in cocaine runway, females	0.8	0.7	1.5	-1.2	-0.8	-0.6	0.9	-0.8	0.8	0.9	0.8
Run reversals in cocaine runway, males	1.2	1.2	3.2	1.2	0.3	0.1	-1.8	0.4	-0.4	-1.4	-1.7
Latency to leave start box in cocaine runway	0.5	0.5	1.0	-0.9	-0.7	-0.9	0.8	-0.2	0.2	0.7	1.0
Latency to leave start box in cocaine runway, F	1.5	1.7	4.2	-1.5	-1.1	-1.0	1.6	-0.6	0.6	1.4	2.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.5	0.1	-0.2	-0.6	-0.4	0.0	-0.0	-0.1	-0.7
Std. dev. time between licks in bursts	3.8	4.6	6.6	-1.6	-1.5	-1.1	2.4	-2.6	2.6	2.6	2.3
Total sessions with >9 infusions	0.2	0.2	0.5	-0.4	0.2	0.1	0.7	-0.3	0.3	0.5	0.6
Short access day 1 total inactive lever presses	1.0	1.1	2.0	-1.0	-0.5	-0.6	1.4	-0.9	0.9	1.4	1.4
Short access day 10 total inactive lever presses	0.6	0.6	1.6	1.3	0.3	0.2	-0.9	-0.8	0.8	-0.2	-1.1
Short access day 1 total infusions	0.3	0.3	0.6	-0.2	0.8	0.5	0.4	0.8	-0.8	-0.1	0.2
Short access day 10 total infusions	0.2	0.2	0.5	0.1	-0.4	-0.7	-0.6	-0.5	0.5	-0.2	-0.5
Short access total infusions	0.0	0.0	0.1	-0.2	-0.1	-0.3	0.0	-0.2	0.2	0.1	0.0
Short access day 1 locomotion	0.7	0.7	1.8	0.7	1.3	1.1	-0.4	0.8	-0.8	-0.7	-0.4
Short access day 10 total locomotion	0.9	1.0	1.4	1.1	1.2	0.9	-0.8	0.9	-0.9	-1.0	-1.0
Short access total locomotion	0.5	0.5	1.3	0.7	1.1	1.0	-0.3	0.7	-0.7	-0.6	-0.4
One hour access (0.3 mA shock)	0.9	1.0	2.5	-0.5	-0.7	-1.4	0.1	-1.6	1.6	0.7	0.2
Compulsive drug intake	0.1	0.1	0.1	0.2	0.3	0.3	0.1	-0.3	0.3	0.1	0.3
One hour access (shock baseline)	1.0	1.1	2.2	-1.0	-1.1	-1.5	0.6	-1.3	1.3	0.8	0.8
Social response proportion	0.3	0.3	0.9	-0.1	0.7	0.8	0.9	-0.1	0.1	0.7	0.4
Social responses	0.4	0.5	1.1	0.0	0.7	0.7	1.1	-0.2	0.2	0.6	1.0
Social time	0.4	0.5	1.3	0.1	1.1	0.9	0.9	0.2	-0.2	0.5	0.8
Soleus weight	0.3	0.8	2.0	0.0	-1.3	-0.6	-0.2	-1.4	1.4	0.4	0.2
Bone: stiffness	1.5	2.4	7.9	1.8	2.8	2.7	0.4	-0.5	0.5	0.0	0.4
Tibialis anterior weight	0.5	1.6	3.0	-1.2	-1.7	-1.7	0.9	-1.2	1.2	1.1	1.0
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.3	-0.6	-0.2	0.1	-0.5	0.5	0.2	0.4
Time to tail flick, vehicle, after self-admin	0.7	0.7	1.2	-0.4	0.9	0.6	1.0	1.1	-1.1	0.2	1.1
Time to tail flick, test, before self-admin	0.1	0.1	0.5	0.0	-0.7	-0.4	-0.2	-0.3	0.3	0.0	-0.6
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.0	0.4	0.2	0.2	0.5	-0.5	0.0	-0.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.2	-1.0	-0.3	-0.7	1.1	0.0	-0.0	0.9	1.1
Delta time to tail flick, test, before/after SA	1.5	1.3	3.5	1.0	1.9	1.5	-0.4	1.2	-1.2	-0.8	-0.4
Tibia length	3.5	9.9	26.3	5.1	4.0	3.8	-3.1	-0.2	0.2	-2.6	-2.4
Ambulatory time before self-admin	1.4	1.5	3.2	1.7	0.9	0.8	-1.8	0.3	-0.3	-1.4	-1.5
Ambulatory time after self-admin	0.5	0.5	2.1	-0.7	-1.5	-1.1	-0.1	-0.4	0.4	0.4	-0.1
Bone: tissue strength	0.8	0.8	1.6	0.4	-0.1	0.8	0.8	-1.3	1.3	0.8	1.0
Total heroin consumption	3.7	4.3	7.7	2.4	2.7	2.8	-1.4	1.8	-1.8	-1.7	-1.5
Bone: trabecular number	0.1	0.1	0.2	-0.4	-0.5	-0.2	0.1	-0.3	0.3	0.2	0.3
Bone: trabecular spacing	2.8	3.6	5.4	-1.6	-1.3	-1.3	2.2	-2.1	2.1	2.3	2.0
Bone: trabecular thickness	2.2	2.7	4.3	1.8	1.5	1.0	-2.1	1.3	-1.3	-1.9	-1.9
Bone: trabecular tissue density	0.1	0.2	0.4	-0.4	0.6	-0.1	0.3	0.6	-0.6	0.0	0.1
Water consumed over 24 hours	0.5	0.6	1.1	0.3	-0.1	-0.1	-1.0	0.9	-0.9	-1.0	-0.8
Number of responses in last shaping day	0.4	0.4	0.7	0.6	0.7	0.8	0.2	-0.8	0.8	0.2	0.2