Hub : Genes

Sec31a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose isoform ratio XM_039092523.1 0.07 0.03 1.1e-06 0.04 0.04 0.04 0.04 7.2e-05 2.7e-05 3.8e-05 1.8e-05
2 NAcc gene expression Sec31a 0.04 0.02 6.4e-04 0.04 0.03 0.02 0.03 3.1e-05 3.3e-04 1.2e-03 1.4e-04
3 Adipose intron excision ratio chr14_9241291_9244201 0.05 0.03 3.4e-05 0.02 0.03 0.03 0.03 1.2e-03 3.5e-04 8.5e-04 2.9e-04
4 Adipose isoform ratio XM_006250688.4 0.06 0.04 4.6e-05 0.01 0.02 0.01 0.01 4.0e-02 2.9e-03 1.4e-02 4.1e-02
5 PL gene expression Sec31a 0.03 0.02 6.6e-04 0.03 0.02 0.01 0.02 1.3e-04 3.2e-03 1.8e-02 3.5e-03
6 Adipose intron excision ratio chr14_9241291_9241735 0.05 0.03 1.3e-03 0.02 0.02 0.01 0.02 2.3e-03 3.4e-03 1.1e-02 2.6e-03
7 Liver gene expression Sec31a 0.06 0.03 4.8e-06 0.04 0.04 0.03 0.04 4.7e-05 3.6e-05 1.1e-04 4.3e-05
8 BLA gene expression Sec31a 0.12 0.07 7.1e-05 0.06 0.07 0.08 0.08 2.7e-04 1.0e-04 3.1e-05 6.9e-05
9 pVTA mRNA stability Sec31a 0.24 0.1 3.0e-03 0.01 0.03 0 0.01 1.2e-01 1.6e-02 3.4e-01 9.7e-02
10 Adipose mRNA stability Sec31a 0.18 0.07 1.1e-16 0.11 0.12 0.12 0.12 6.0e-12 7.6e-13 3.2e-13 2.4e-13
11 Brain mRNA stability Sec31a 0.04 0.02 7.0e-04 0.03 0.02 0.03 0.02 5.8e-04 4.5e-03 1.5e-03 5.5e-03
12 Brain gene expression Sec31a 0.12 0.05 1.0e-09 0.05 0.1 0.1 0.1 9.7e-06 1.5e-09 8.8e-10 6.6e-10
13 Adipose intron excision ratio chr14_9241812_9244201 0.03 0.02 4.9e-04 0.01 0.02 0.01 0.01 1.8e-02 4.7e-03 1.2e-02 8.7e-03
14 pVTA intron excision ratio chr14_9239565_9241253 0.13 0.07 6.8e-03 0.02 0.07 0.07 0.04 6.3e-02 6.3e-04 5.6e-04 9.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.62.66.51.91.72.5-2.11.71.51.50.61.91.6-2.00.0-0.7-0.6
Area under the delay curve1.31.44.01.01.00.30.01.01.31.21.8-0.61.3-1.4-2.00.21.0
BMI with tail1.75.711.42.02.40.8-0.92.42.13.02.32.83.0-2.6-2.31.93.4
BMI without tail0.61.24.20.70.91.0-0.40.90.41.20.52.11.3-1.5-0.31.60.9
Body weight1.77.211.63.13.32.8-3.13.32.93.02.03.43.0-2.0-1.6-0.51.7
Weight adjusted by age2.02.24.91.91.91.7-2.11.81.81.21.20.20.9-0.1-1.1-2.20.2
Bone surface1.22.14.41.71.92.0-1.61.61.61.60.90.91.4-2.1-0.6-0.90.4
Bone volume1.32.15.01.61.62.1-2.21.51.51.20.31.71.1-1.70.2-1.4-0.7
Breakpoint value in progressive ratio session0.10.10.8-0.2-0.10.3-0.1-0.10.2-0.1-0.10.6-0.10.40.20.00.9
Number of licking bursts0.30.30.7-0.5-0.1-0.80.8-0.8-0.2-0.5-0.7-0.5-0.7-0.00.20.50.4
Context. condit. distance diff. score1.01.22.90.81.3-0.6-1.71.31.01.00.71.30.70.2-0.2-1.61.2
Locomotion velocity, session 10.60.62.10.70.90.9-0.90.70.40.70.8-1.00.4-0.6-0.7-1.50.4
Locomotion distance, session 12.53.25.21.92.32.0-1.82.02.01.82.0-0.51.7-1.4-1.8-2.00.9
Locomotion velocity, session 20.20.31.10.10.20.60.30.3-0.00.50.6-0.80.6-0.4-1.00.30.4
Locomotion distance, session 22.23.16.72.01.92.6-1.31.82.01.82.1-0.51.8-1.9-1.9-0.90.4
Locomotion velocity, session 30.20.21.3-0.50.1-0.4-0.30.2-0.2-0.00.2-0.7-0.20.9-0.3-1.10.1
Locomotion distance, session 30.70.81.70.81.10.9-1.21.30.90.90.80.70.9-0.2-0.5-0.80.8
Stereotopy head waving bouts, day 31.41.76.4-0.6-0.7-0.1-0.1-1.0-0.9-1.4-1.2-1.6-1.60.91.3-1.8-2.5
Stereotopy head waving duration, day 31.31.55.3-0.8-0.7-0.3-0.1-1.1-0.8-1.5-1.4-0.8-1.51.31.6-1.4-2.3
Locomotion velocity, session 70.80.92.40.80.91.4-1.61.00.90.50.40.70.6-0.2-0.0-1.4-1.2
Locomotion distance, session 71.01.32.71.21.01.2-0.41.11.61.21.20.11.2-1.7-1.50.10.8
Stereotopy head waving bouts, day 70.60.73.0-0.30.2-0.0-1.0-0.1-0.4-0.5-0.50.1-0.91.71.0-1.6-1.0
Stereotopy head waving duration, day 71.01.23.4-0.8-0.5-0.4-0.5-0.7-1.1-1.1-1.00.1-1.31.81.5-1.3-1.6
Locomotion velocity, session 80.30.32.50.20.4-0.1-1.20.50.10.20.00.20.10.50.1-1.6-0.3
Locomotion distance, session 80.81.13.21.11.40.8-1.51.21.00.91.3-0.10.8-0.3-0.9-1.80.5
Degree of sensitization distance0.50.51.5-0.2-0.4-0.71.2-0.50.20.00.2-0.70.0-1.0-0.91.10.6
Degree of sensitization stereotypy0.30.32.1-0.30.0-0.4-0.4-0.1-0.4-0.3-0.20.5-0.61.50.7-0.6-0.1
Conditioned locomotion1.01.14.11.30.91.5-2.01.30.70.70.61.00.40.2-0.1-1.6-0.4
Cocaine response after cond. corrected0.80.91.9-0.9-1.2-1.11.0-1.1-1.1-0.7-0.90.6-0.90.40.81.40.1
Cocaine response after cond. not corrected0.70.81.7-1.0-1.0-1.11.0-1.0-1.2-0.6-0.80.3-0.80.40.51.30.1
Cocaine response before conditioning0.10.21.3-0.2-0.00.40.3-0.2-0.4-0.10.0-1.20.0-0.2-0.3-0.2-0.6
Saline control response0.40.61.90.80.80.8-0.60.60.50.40.9-1.10.2-0.1-0.8-1.40.4
Bone: connectivity density1.32.05.01.61.62.2-1.71.41.31.40.51.61.5-2.0-0.1-0.3-0.5
Bone: cortical apparent density0.10.10.4-0.2-0.30.20.1-0.2-0.4-0.4-0.4-0.6-0.30.30.1-0.3-0.7
Bone: cortical area0.91.44.01.51.32.0-1.51.11.31.01.00.80.7-1.3-0.3-0.9-0.5
Bone: cortical porosity0.60.74.41.40.42.1-0.60.50.40.50.6-0.10.5-1.0-0.40.0-0.4
Bone: cortical porosity0.40.42.71.10.01.7-0.20.10.00.10.2-0.00.2-1.00.00.4-0.5
Bone: cortical thickness0.20.41.80.90.61.3-0.70.40.40.40.50.10.2-0.9-0.1-0.5-0.5
Bone: cortical thickness0.70.83.91.10.62.0-0.00.10.50.20.5-0.60.4-1.80.10.2-0.9
Bone: cortical tissue density0.20.20.4-0.4-0.50.00.3-0.4-0.6-0.5-0.6-0.7-0.50.50.3-0.2-0.7
Condit. Reinf. active minus inactive responses0.20.20.8-0.1-0.3-0.4-0.6-0.40.1-0.20.20.9-0.20.60.6-0.4-0.6
Condit. Reinf. active-inactive response ratio0.50.54.8-0.00.1-0.8-0.90.00.30.20.12.20.10.50.7-0.10.2
Condit. Reinf. active responses0.30.41.10.70.60.5-0.80.40.70.50.9-0.30.5-0.5-0.6-1.00.0
Condit. Reinf. inactive responses1.01.23.71.11.01.7-0.60.70.80.60.9-1.90.6-1.0-1.2-1.6-0.3
Incentive salience index mean0.20.20.8-0.0-0.3-0.1-0.4-0.40.0-0.30.5-0.4-0.30.60.0-0.9-0.8
Condit. Reinf. lever presses0.71.02.61.00.61.1-0.90.70.80.61.5-1.30.5-0.3-1.3-1.6-0.5
Condit. Reinf. active minus inactive responses0.30.30.90.50.30.70.40.20.50.30.7-0.90.4-0.8-0.90.10.5
Condit. Reinf. active-inactive response ratio0.40.41.30.50.40.70.8-0.10.40.30.5-0.90.5-1.1-1.10.70.6
Condit. Reinf. active responses0.20.32.0-0.2-0.4-0.30.9-0.0-0.10.10.4-1.40.1-0.3-0.80.20.6
Condit. Reinf. inactive responses0.20.31.0-0.7-0.8-1.00.3-0.2-0.5-0.3-0.2-0.4-0.40.90.3-0.3-0.0
Condit. Reinf. lever presses0.71.02.2-1.3-1.1-1.51.2-0.9-1.0-0.9-0.8-1.4-1.01.00.3-0.1-0.0
Condit. Reinf. lever reinforcers received0.20.31.5-0.5-0.7-0.51.0-0.4-0.4-0.30.0-1.2-0.20.0-0.30.40.5
Conditioned reinforcement - actives2.32.34.1-1.6-1.9-1.11.7-2.0-1.7-1.8-1.5-1.7-1.60.31.50.4-1.4
Conditioned reinforcement - inactives0.20.20.8-0.8-0.4-0.50.4-0.4-0.9-0.4-0.3-0.6-0.30.40.30.0-0.2
Conditioned locomotion1.01.12.8-1.7-0.9-1.11.0-1.1-1.3-1.2-1.1-0.8-1.01.40.70.1-0.8
Patch foraging indifference point 0 sec0.40.71.70.61.2-0.1-0.20.80.70.91.1-0.70.7-0.5-1.3-0.61.3
Patch foraging indifference point AUC0.30.31.10.10.20.6-1.00.30.0-0.2-0.70.6-0.20.10.3-1.1-0.9
Delay disc. indifference point, 0s delay1.01.12.91.20.80.7-0.10.90.71.11.4-1.31.0-1.7-1.5-0.20.5
Delay disc. indifference point, 16s delay0.30.31.4-0.4-0.5-0.30.6-0.6-0.1-0.50.1-1.2-0.20.3-0.30.1-1.1
Delay disc. indifference point, 2s delay1.21.42.61.21.10.1-0.51.31.31.41.60.61.4-1.2-1.50.21.6
Delay disc. indifference point, 24s delay0.90.93.7-1.3-0.8-1.91.1-0.9-0.8-0.8-0.5-0.6-0.91.0-0.10.50.4
Delay disc. indifference point, 4s delay3.13.36.82.11.71.4-1.02.01.82.12.6-0.32.1-2.3-2.3-0.51.2
Delay disc. indifference point, 8s delay1.11.22.40.91.00.2-0.11.01.41.21.50.51.4-1.1-1.60.61.4
Indifference point function ln k0.50.72.60.20.0-0.01.00.1-0.00.61.0-1.10.7-0.5-0.91.11.6
Indifference point function log k0.50.72.60.20.0-0.01.00.1-0.00.61.0-1.10.7-0.5-0.91.11.6
Patch foraging total patch changes 0 sec0.71.12.90.81.40.2-0.31.00.91.11.4-1.01.0-0.8-1.7-0.81.3
Patch foraging total patch changes 12 sec0.10.10.20.20.40.3-0.00.30.20.30.30.10.5-0.3-0.40.40.0
Patch foraging total patch changes 18 sec0.60.82.51.00.91.2-1.10.70.90.30.5-0.60.4-0.9-0.5-1.6-1.2
Patch foraging total patch changes 24 sec2.73.35.82.42.41.6-2.42.02.41.71.52.11.7-1.5-0.9-1.20.2
Patch foraging total patch changes 6 sec1.11.63.11.21.8-0.0-1.21.41.61.41.11.51.3-1.0-1.1-0.51.6
Patch foraging time to switch 0 sec0.20.31.3-0.5-0.5-0.50.5-0.6-0.0-0.40.10.8-0.10.20.51.1-0.6
Patch foraging water rate 0 sec0.20.31.2-0.40.0-0.4-0.10.2-0.5-0.1-0.3-1.1-0.30.8-0.3-1.00.3
Patch foraging water rate 12 sec2.03.17.62.32.01.9-2.82.01.91.61.50.71.2-1.1-0.6-2.70.2
Patch foraging water rate 18 sec2.53.36.02.22.21.6-1.82.22.42.12.10.72.0-1.2-1.8-1.01.2
Patch foraging water rate 24 sec2.33.25.62.32.22.2-2.42.21.91.81.70.81.8-0.9-1.0-1.70.3
Patch foraging water rate 6 sec0.40.63.80.60.71.1-0.80.10.1-0.10.1-1.3-0.2-0.00.1-1.9-0.8
Seeking ratio, delayed vs. immediate footshock2.12.54.21.82.01.5-1.72.11.81.71.61.01.7-1.5-1.4-0.80.8
Distance traveled before self-admin0.20.21.10.60.30.2-0.20.20.60.40.40.20.6-1.00.1-0.1-0.3
Distance traveled after self-admin0.30.31.80.40.30.5-0.60.30.0-0.00.2-1.00.1-0.40.1-1.3-0.4
Extensor digitorum longus weight4.417.428.05.34.85.1-4.94.94.84.64.31.34.2-3.2-3.6-3.41.6
Bone: elastic displacement0.70.82.21.10.61.5-0.30.70.60.70.8-1.10.8-1.2-1.1-0.4-0.3
Bone: elastic work0.40.52.01.00.51.4-0.40.40.50.40.7-0.60.5-1.3-0.4-0.3-0.8
Bone: endosteal estimation0.40.91.91.01.10.9-1.21.11.40.80.61.40.9-0.7-0.2-0.50.1
Bone: endosteal perimeter1.02.24.41.61.81.7-2.11.81.81.51.11.41.5-1.1-0.8-1.30.1
Epididymis fat weight0.41.03.40.71.10.0-0.51.10.71.20.71.21.2-0.6-1.10.61.8
Delta time in closed arm before/after self-admin1.71.75.61.51.20.9-0.71.11.51.41.6-0.61.3-2.4-1.5-0.60.7
Delta time in open arm before/after self-admin5.45.27.8-2.8-2.5-2.12.4-2.6-2.5-2.2-2.70.9-2.12.12.32.7-0.9
Diff in mean of infusions in LGA sessions1.01.13.5-1.7-0.9-1.91.2-0.8-0.8-0.6-0.60.4-0.61.50.21.01.1
Delay discount exponential model param1.31.44.2-1.0-1.0-0.1-0.0-1.0-1.4-1.3-1.80.5-1.31.32.0-0.2-1.2
Extinction: sum of active levers before priming0.60.62.6-0.6-0.3-0.5-0.8-0.1-0.4-0.6-0.90.7-0.61.61.0-1.2-0.7
Active lever presses in extinction session 60.40.42.20.60.20.6-0.60.40.90.40.21.50.4-0.6-0.10.30.5
Bone: final force1.32.03.41.81.81.4-1.31.51.81.61.11.71.4-1.8-0.6-0.00.9
Bone: final moment1.72.74.62.02.01.6-1.31.82.01.81.31.91.7-2.2-0.80.21.2
Food consumed during 24 hour testing period1.51.83.6-1.1-1.7-0.21.2-1.4-1.3-1.6-1.4-1.8-1.51.21.1-0.1-1.9
Glucose0.40.72.70.51.00.20.20.71.20.71.0-0.90.8-0.6-1.7-0.00.6
Heart weight1.82.54.61.92.11.1-1.41.91.81.81.41.11.6-1.9-0.8-0.61.8
Delay discount hyperbolic model param2.02.15.2-1.3-1.3-0.30.2-1.4-1.7-1.7-2.20.2-1.71.72.3-0.2-1.6
Intermittent access intake day 1-15 change0.40.41.40.50.10.6-1.10.20.0-0.2-0.10.3-0.20.40.6-1.1-1.2
Intermittent access intake escalation0.40.41.30.80.30.8-1.10.50.40.20.30.30.2-0.10.1-1.0-0.7
Intermittent access intake escalation 21.11.12.31.01.10.8-1.51.31.11.11.20.61.0-0.6-1.0-1.20.3
Intermitt. access day 1 inactive lever presses1.31.44.21.11.40.5-2.11.51.21.21.11.41.1-0.6-0.4-1.40.1
Intermitt. access day 15 inactive lever presses1.31.45.20.71.40.3-2.31.51.00.80.71.90.70.70.0-1.7-0.2
Intermitt. access escalation Index0.50.41.2-0.6-0.2-1.00.5-0.4-0.3-0.3-0.61.1-0.30.70.70.90.8
Intermittent access day 1 total infusions1.11.33.0-1.5-1.2-1.71.2-1.3-1.1-1.0-1.10.5-0.80.91.01.3-0.4
Intermittent access day 15 total infusions0.50.51.6-0.5-0.6-0.7-0.1-0.6-0.3-0.7-0.61.3-0.40.91.10.3-1.0
Intermittent access terminal intake (last 3 days)0.40.51.9-0.3-0.3-0.5-0.6-0.3-0.2-0.5-0.61.4-0.30.81.2-0.4-0.9
Intermittent access total infusions0.91.02.2-1.1-0.9-1.20.5-1.0-0.9-0.9-1.11.4-0.71.01.50.9-0.6
Intermittent access day 1 locomotion0.80.81.4-1.2-1.0-1.01.0-1.1-0.8-1.0-0.9-0.2-0.71.10.70.7-0.9
Intermittent access day 15 total locomotion1.92.03.3-1.7-1.8-1.01.1-1.7-1.5-1.7-1.5-0.4-1.41.41.50.6-1.8
Intermittent access total locomotion1.51.72.8-1.7-1.4-1.41.0-1.4-1.2-1.5-1.30.1-1.11.71.30.8-1.3
Intermittent access standard deviation0.80.92.40.81.00.9-1.51.30.61.00.91.21.2-0.6-0.2-0.7-0.3
Left kidney weight1.85.210.02.53.22.1-2.42.92.82.62.11.52.3-1.9-1.7-1.31.7
Right kidney weight2.05.610.72.63.32.3-2.32.92.92.72.21.72.6-1.9-1.8-1.02.0
Cocaine induced anxiety0.70.83.20.40.60.40.20.60.70.61.1-1.80.5-0.3-1.7-0.60.9
Post-drug Anxiety0.30.41.00.60.70.7-0.60.70.70.50.7-0.70.40.1-0.7-1.00.0
Baseline Anxiety2.02.18.4-1.0-1.1-0.6-0.6-1.1-1.2-1.5-1.91.2-1.41.62.9-0.8-1.9
Tail length0.31.04.10.60.41.9-1.50.3-0.0-0.2-0.60.8-0.20.31.1-1.3-2.0
Length with tail0.93.19.42.02.02.7-3.11.91.71.00.51.50.9-0.3-0.0-2.5-1.3
Length without tail1.22.65.11.82.31.4-2.22.02.01.51.31.21.5-0.3-1.1-1.80.8
Times rat made contact with spout0.40.52.1-0.10.4-0.10.70.40.40.40.6-1.50.4-0.2-1.1-0.01.2
Lifetime Intake0.70.81.9-1.0-0.8-1.00.5-1.0-0.7-0.8-1.01.3-0.50.71.41.0-0.5
Liver weight, left3.35.29.42.23.12.0-2.52.83.02.42.52.02.6-1.7-2.0-1.00.6
Liver weight, right0.60.94.2-0.6-0.20.2-0.5-0.2-0.6-0.8-0.5-1.4-0.61.00.1-1.9-2.0
Locomotor activity0.20.31.40.70.40.8-0.10.30.50.20.6-1.20.1-0.3-0.3-0.80.1
Locomotor testing distance0.91.53.51.70.91.8-0.80.81.10.61.3-1.90.4-1.3-0.8-1.7-0.5
Locomotor testing rearing0.81.33.01.31.01.10.00.81.31.11.7-1.00.9-1.7-1.3-0.01.0
Locomotion in novel chamber2.53.14.71.72.00.9-1.51.92.02.22.11.92.1-1.5-1.60.11.9
Locomotion in novel chamber post-restriction0.60.72.6-0.6-0.1-1.21.2-0.4-0.30.40.5-0.40.4-0.8-0.81.41.6
Fecal boli incidents, locomotor time 10.70.82.80.40.8-0.5-0.10.50.61.00.61.11.0-1.7-0.60.71.4
Change in fecal boli incidents, locomotor task1.11.05.90.90.51.6-0.10.60.50.20.9-2.40.2-0.1-1.2-1.3-0.5
Time >=10cm from walls, locomotor time 11.21.22.40.91.10.3-1.61.51.31.21.20.71.2-0.6-1.3-1.40.2
Bouts of movement, locomotor time 10.80.83.7-1.1-0.5-0.81.5-0.9-1.0-0.4-0.5-0.0-0.20.3-0.21.91.0
Total resting periods, locomotor time 10.70.82.5-1.1-0.6-0.51.5-1.0-1.1-0.6-0.5-0.5-0.50.5-0.21.60.5
Rest time, locomotor task time 10.10.21.30.30.21.20.0-0.1-0.3-0.20.1-0.6-0.10.2-0.10.0-0.4
Distance moved, locomotor task time 10.40.51.20.50.4-0.1-0.50.80.90.80.41.10.8-0.9-0.00.00.9
Vertical activity count, locomotor time 10.20.21.0-0.1-0.1-1.0-0.10.20.60.30.10.40.2-0.70.3-0.20.4
Time >=10cm from walls, locomotor time 20.70.83.8-0.1-0.60.40.4-0.7-0.4-0.9-0.4-2.0-1.00.40.5-0.9-1.5
Bouts of movement, locomotor time 20.91.04.1-1.4-0.8-2.01.1-0.9-1.2-0.8-0.8-0.3-0.80.90.60.60.3
Total resting periods, locomotor time 21.11.23.9-1.5-0.9-2.01.3-1.1-1.4-0.9-0.9-0.7-0.90.90.50.70.1
Rest time, locomotor task time 20.20.21.0-0.20.40.4-0.90.4-0.2-0.0-0.20.2-0.00.50.1-1.0-0.6
Distance moved, locomotor task time 20.20.31.1-0.0-0.4-0.50.5-0.30.2-0.0-0.40.9-0.00.00.41.10.9
Vertical activity count, locomotor time 20.30.31.00.50.1-0.80.00.30.90.60.40.60.4-0.6-0.20.41.0
Light reinforcement 11.01.84.91.21.51.6-1.61.61.11.11.6-0.91.0-0.6-1.2-2.2-0.4
Light reinforcement 20.10.10.60.10.10.2-0.30.20.10.00.2-0.5-0.20.8-0.6-0.70.1
Bone: marrow area0.40.91.81.01.11.0-1.11.11.30.80.71.30.9-0.7-0.3-0.40.1
Bone: maximum diameter0.20.41.10.70.71.1-1.10.40.70.20.20.7-0.0-0.50.3-0.9-0.7
Bone: maximum force1.62.85.52.02.21.7-2.11.82.01.71.12.31.5-1.8-0.3-0.70.6
Bone: maximum moment2.03.56.32.22.41.8-2.12.12.22.01.32.51.8-2.1-0.5-0.51.0
Mean time between licks in bursts1.11.64.2-1.7-1.4-2.12.0-1.3-1.4-0.8-0.4-0.9-0.90.2-0.01.60.3
Mean num. licks in bursts0.30.41.00.50.30.8-0.50.90.40.61.0-0.40.7-0.0-0.7-0.60.0
Cd content in liver0.40.42.7-0.2-0.4-0.50.5-0.60.0-0.5-0.3-1.7-0.80.1-0.1-0.90.2
Co content in liver0.50.62.60.60.10.51.0-0.30.60.30.4-0.20.6-1.5-0.41.60.8
Cu content in liver2.73.27.02.32.02.3-1.11.82.21.91.60.32.2-2.7-1.7-0.10.5
Fe content in liver0.70.84.81.40.62.2-0.90.60.30.50.6-0.50.4-0.9-0.2-0.7-0.8
K content in liver2.32.34.8-1.5-1.4-1.20.2-1.2-1.2-1.9-2.20.4-1.72.12.1-0.7-1.9
Mg content in liver1.01.02.5-0.8-0.9-0.6-0.3-0.5-0.8-1.1-1.60.5-1.01.01.5-0.8-1.5
Mn content in liver0.40.51.1-0.7-0.5-0.40.1-0.6-0.4-0.8-0.80.8-0.50.90.90.3-1.0
Na content in liver1.01.12.51.11.61.2-1.11.31.21.00.40.40.9-1.6-0.4-0.90.3
Rb content in liver0.91.15.9-0.6-0.6-1.41.8-0.8-0.3-0.1-0.20.20.1-0.6-0.32.41.4
Se content in liver0.20.31.40.20.1-0.2-0.80.20.00.0-0.41.2-0.1-0.31.0-0.6-0.4
Sr content in liver2.42.26.51.21.80.1-1.11.51.81.61.42.61.8-1.2-0.80.51.6
Zn content in liver0.70.81.51.20.61.2-0.60.81.10.91.2-0.11.0-1.1-0.9-0.3-0.2
Bone: minimum diameter0.40.81.40.81.11.1-1.21.01.20.91.00.90.6-0.8-0.5-0.60.1
Time in familiar zone, hab. session 10.70.72.21.10.71.1-1.40.70.60.3-0.30.50.3-0.30.6-1.5-0.5
Time in novel zone, hab. session 10.60.61.8-1.0-0.9-0.91.3-0.8-0.7-0.7-0.3-1.3-0.70.1-0.20.6-0.1
Total zone transitions, hab. session 10.40.51.80.90.91.4-0.50.60.70.50.7-0.60.5-0.4-0.7-0.70.4
Total locomotion distance, hab. session 11.52.28.91.51.52.5-1.81.31.10.60.7-1.60.4-0.0-0.9-3.0-0.7
Locomotion velocity, hab. session 11.21.75.71.41.42.1-1.51.21.00.70.9-1.20.50.1-1.1-2.4-0.4
Time in familiar zone, hab. session 20.90.91.41.01.1-0.1-1.01.21.21.20.61.01.1-0.9-0.9-0.61.1
Time in novel zone, hab. session 20.90.91.6-0.9-1.10.01.0-1.2-1.3-1.1-0.7-0.6-1.00.71.10.8-0.9
Total zone transitions, hab. session 22.53.36.72.02.02.1-1.31.91.61.92.6-1.11.9-1.3-2.4-1.41.0
Total locomotion distance, hab. session 22.63.59.52.01.82.9-1.81.71.61.21.7-2.41.1-0.5-1.9-3.1-0.4
Locomotion velocity, hab. session 22.33.18.91.81.72.7-1.61.61.41.11.6-2.40.9-0.3-1.8-3.0-0.5
Novel to familiar place preference ratio0.20.20.7-0.4-0.2-0.00.20.1-0.40.00.00.8-0.10.50.40.80.5
Novelty place preference0.40.41.7-0.7-0.5-0.40.7-0.2-0.8-0.1-0.20.7-0.20.80.51.30.7
Time in novel zone, NPP test0.30.31.4-0.7-0.5-0.40.7-0.2-0.8-0.2-0.20.5-0.30.60.51.20.6
Total zone transitions, NPP test0.81.23.11.11.11.3-0.70.90.80.91.8-1.50.8-0.7-1.4-1.30.0
Total locomotion distance, NPP test1.82.54.91.61.72.1-1.51.61.41.31.8-1.61.2-0.6-1.9-2.20.1
Locomotion velocity, NPP test1.72.44.31.61.82.1-1.41.71.41.41.8-1.41.3-0.6-2.0-2.00.3
Intraocular pressure0.50.73.6-0.9-0.7-0.51.7-0.7-0.8-0.20.2-0.80.1-0.3-0.61.90.3
Delta distance traveled before/after self-admin0.50.63.2-0.00.10.7-0.80.1-0.5-0.5-0.3-1.2-0.50.60.3-1.8-1.0
Delta ambulatory time before/after self-admin1.61.74.6-0.5-0.90.5-0.3-0.8-1.4-1.4-1.2-2.2-1.61.01.1-2.0-1.8
Parametrial fat weight1.22.34.71.52.21.5-1.21.71.71.61.5-0.71.4-0.9-2.1-1.31.1
Pavlov. Cond. lever latency0.50.61.90.40.20.6-1.30.30.2-0.2-0.81.4-0.30.70.8-0.9-1.0
Pavlov. Cond. magazine entry latency0.60.72.10.40.60.40.60.30.60.71.4-1.20.9-1.2-1.30.50.6
Pavlov. Cond. change in total contacts0.50.51.50.50.50.20.30.30.50.71.2-0.50.7-1.1-0.90.51.1
Pavlov. Cond. index score0.50.62.20.30.50.20.50.30.40.71.5-1.10.9-1.2-1.20.30.7
Pavlov. Cond. latency score0.50.72.20.30.40.10.60.30.40.71.5-1.40.8-1.1-1.30.20.7
Pavlov. Cond. lever contacts0.50.62.2-0.2-0.0-0.31.2-0.10.10.31.0-1.50.5-1.0-1.10.80.8
Pavlov. Cond. magazine entry number0.81.02.9-0.6-0.9-0.1-0.3-0.6-0.8-1.1-1.70.5-1.21.51.5-0.6-1.4
Pavlov. Cond. intertrial magazine entries1.72.04.0-1.0-1.8-0.31.2-1.7-1.7-1.7-2.0-1.1-1.70.61.90.3-1.2
Pavlov. Cond. lever-magazine prob. diff.0.60.72.20.40.50.20.50.30.40.81.5-1.10.9-1.3-1.20.40.8
Pavlov. Cond. response bias0.50.61.80.20.50.00.60.20.40.71.3-1.10.7-1.1-1.20.51.0
Pavlov. Cond. lever latency0.71.02.51.21.01.5-1.61.00.90.80.71.60.8-0.6-0.0-0.4-0.6
Pavlov. Cond. magazine entry latency0.91.11.8-1.2-1.1-1.01.3-1.2-1.2-1.2-1.0-0.5-1.11.10.90.9-0.5
Pavlov. Cond. change in total contacts1.82.55.8-1.9-1.9-1.52.4-1.8-1.7-1.6-1.3-2.1-1.51.10.61.0-0.4
Pavlov. Cond. index score1.51.93.5-1.6-1.6-1.31.9-1.5-1.6-1.4-1.3-1.8-1.41.30.60.6-0.3
Pavlov. Cond. latency score1.82.23.6-1.7-1.7-1.21.8-1.6-1.7-1.6-1.5-1.9-1.61.50.90.4-0.7
Pavlov. Cond. lever contacts0.40.52.0-0.8-0.7-1.11.1-0.5-0.6-0.4-0.4-1.4-0.50.3-0.2-0.00.5
Pavlov. Cond. magazine entry number1.01.22.71.41.21.1-1.61.21.31.10.91.21.0-1.2-0.5-0.90.1
Pavlov. Cond. intertrial magazine entries0.10.10.8-0.3-0.30.20.0-0.5-0.4-0.4-0.3-0.4-0.30.10.2-0.2-0.9
Pavlov. Cond. lever-magazine prob. diff.1.72.23.9-1.7-1.7-1.22.0-1.6-1.7-1.5-1.4-1.9-1.51.40.70.7-0.5
Pavlov. Cond. response bias0.50.62.1-0.9-0.8-1.31.4-0.6-0.7-0.4-0.3-0.8-0.30.4-0.31.00.9
Time in closed arm before self-admin0.70.71.61.31.01.0-0.91.11.01.00.80.80.8-0.5-0.7-0.20.4
Time in closed arm after self-admin3.73.86.72.62.22.3-1.72.12.22.22.10.52.1-2.5-1.9-0.80.5
Time in open arm before self-admin0.80.94.10.91.00.8-1.51.10.70.60.9-0.50.6-0.1-0.6-2.00.2
Time in open arm after self-admin0.60.71.5-1.2-0.9-0.60.8-0.7-1.1-0.7-0.90.3-0.61.00.70.9-0.2
Bone: periosteal estimation0.61.32.91.41.41.7-1.61.21.41.00.81.20.8-1.0-0.2-0.9-0.3
Bone: periosteal perimeter1.21.94.01.71.71.9-2.01.51.71.31.11.21.2-1.1-0.7-1.2-0.2
Bone: post-yield work1.21.64.71.31.51.4-2.21.31.41.00.31.90.9-0.60.3-1.4-0.1
Progressive ratio test 1 active lever presses1.21.32.4-1.2-1.2-1.01.1-1.4-0.9-1.3-1.40.4-0.90.81.61.0-1.2
Progressive ratio test 1 breakpoint1.31.42.9-1.3-1.1-1.01.0-1.4-1.1-1.4-1.60.4-1.01.11.70.8-1.0
Progressive ratio test 1 inactive lever presses1.61.73.40.91.3-0.5-0.91.31.81.61.51.61.6-1.1-1.30.21.5
Progressive ratio test 2 active lever presses1.61.83.7-1.5-1.5-1.30.8-1.6-1.3-1.5-1.60.2-1.21.01.90.4-1.7
Progressive ratio test 2 breakpoint2.52.85.7-1.8-1.9-1.40.9-1.9-1.8-2.0-2.00.1-1.61.42.40.3-2.1
Progressive ratio test 2 inactive lever presses0.91.03.7-1.5-1.0-1.91.1-1.0-0.9-0.8-0.70.4-0.50.80.81.1-0.2
Incentive Sensitization - Responses4.54.56.8-2.1-2.6-1.51.6-2.5-2.5-2.6-2.5-1.0-2.51.92.50.4-2.1
Incentive Sensitization - Breakpoint3.94.06.0-2.0-2.4-1.41.3-2.3-2.3-2.5-2.3-0.8-2.42.02.40.2-2.1
Sum of active levers in priming session hrs 5-62.12.15.3-1.7-1.3-1.00.2-1.2-1.5-1.5-1.91.6-1.42.02.30.1-0.5
Progressive ratio0.91.12.9-1.4-1.0-1.1-0.1-0.6-1.1-1.0-0.91.1-1.01.71.1-0.0-1.2
Food seeking constrained by brief footshock1.31.64.81.41.31.8-2.21.30.90.90.61.50.9-0.9-0.0-1.5-0.7
Seeking ratio, punishment vs. effort2.63.27.32.72.12.7-2.01.81.91.71.30.51.7-2.0-1.1-1.30.5
Retroperitoneal fat weight1.23.812.61.12.3-0.2-0.62.11.92.41.81.92.4-1.5-2.11.03.6
Reaction time number correct0.50.71.5-1.2-0.9-1.20.9-0.7-1.0-0.7-0.7-0.4-0.71.00.50.4-0.0
Reaction time mean minus median0.50.72.50.60.80.30.20.70.80.80.90.30.8-0.6-1.20.81.6
Reaction time mean minus median AUC0.50.72.80.50.60.20.60.50.60.70.80.30.7-0.8-1.01.41.7
Reaction time num false alarms1.11.53.01.51.21.2-1.21.51.61.41.10.91.4-1.7-0.6-0.40.1
Reaction time num false alarms AUC0.81.12.11.31.00.8-1.11.31.41.30.90.91.2-1.4-0.5-0.40.1
Reaction time trials correct on left0.50.71.5-1.2-0.9-1.20.9-0.7-1.0-0.7-0.7-0.4-0.71.00.50.4-0.0
Reaction time trials on left0.40.51.2-1.1-0.8-1.10.8-0.5-0.9-0.6-0.7-0.3-0.60.90.50.40.1
Reaction time mean1.41.94.81.41.41.0-0.61.71.21.71.50.21.5-0.9-2.20.22.1
Reaction time mean AUC1.01.43.41.21.20.8-0.61.51.11.41.20.31.3-0.6-1.70.11.9
Median of all reaction times0.91.33.41.11.10.7-0.61.50.91.41.10.21.3-0.5-1.80.01.7
Reaction time omissions1.21.75.81.51.30.5-1.61.51.41.30.62.41.2-0.9-0.2-0.11.4
Reaction time false alarm rate1.41.93.71.81.41.4-1.31.51.81.61.31.01.6-1.9-0.9-0.30.2
Reaction time premature initiation rate0.60.81.9-1.3-0.6-0.90.5-0.7-1.4-1.0-1.0-0.5-1.00.91.1-0.4-0.4
Reaction time premature initiations1.21.73.7-1.9-1.1-1.61.0-1.1-1.9-1.4-1.4-0.7-1.41.51.4-0.1-0.5
Std. dev. reaction times1.31.83.21.51.51.1-0.81.61.41.61.60.41.5-1.1-1.80.01.6
Reaction time trials completed0.40.51.2-1.1-0.8-1.10.8-0.5-0.9-0.6-0.7-0.3-0.60.90.50.40.1
Reaction time trials AUC0.30.41.1-1.0-0.7-1.00.7-0.4-0.8-0.5-0.6-0.2-0.50.80.50.30.1
Run reversals in cocaine runway, females0.40.41.60.70.50.1-0.20.50.70.60.50.10.6-1.3-0.40.00.8
Run reversals in cocaine runway, males0.30.20.60.60.80.6-0.50.20.10.50.30.80.3-0.70.20.20.5
Latency to leave start box in cocaine runway0.40.42.9-0.2-0.60.60.1-0.7-0.4-0.6-0.3-0.2-0.5-0.10.80.2-1.7
Latency to leave start box in cocaine runway, F0.20.21.70.1-0.10.4-0.1-0.40.2-0.30.00.1-0.2-0.20.3-0.0-1.3
Latency to leave start box in cocaine runway, M0.20.21.1-0.2-0.50.50.4-0.4-0.6-0.4-0.2-0.5-0.3-0.20.60.2-1.0
Std. dev. time between licks in bursts0.60.72.8-0.4-0.50.70.6-0.7-0.8-0.8-0.4-1.6-0.70.00.3-0.1-1.7
Total sessions with >9 infusions0.10.10.5-0.40.1-0.60.4-0.30.1-0.1-0.00.60.10.20.10.70.3
Short access day 1 total inactive lever presses0.60.61.0-1.0-1.0-0.70.9-0.9-1.0-0.7-0.6-0.5-0.4-0.00.90.7-1.0
Short access day 10 total inactive lever presses1.51.63.01.11.51.2-1.21.71.01.51.7-0.41.4-1.0-1.6-1.10.7
Short access day 1 total infusions0.40.41.00.40.60.50.10.40.90.60.50.81.0-1.0-0.30.90.5
Short access day 10 total infusions0.30.32.0-0.2-0.0-0.8-0.1-0.20.4-0.1-0.51.4-0.10.40.80.40.2
Short access total infusions0.20.30.7-0.6-0.3-0.50.4-0.6-0.4-0.4-0.60.7-0.10.40.80.7-0.2
Short access day 1 locomotion1.71.83.41.31.80.9-1.41.61.71.61.60.81.8-1.1-1.5-0.50.3
Short access day 10 total locomotion1.61.83.1-1.8-1.5-1.61.7-1.5-1.5-1.3-1.3-0.7-1.11.70.61.3-0.4
Short access total locomotion0.10.11.1-0.30.10.1-0.1-0.0-0.2-0.3-0.3-0.3-0.11.0-0.1-0.2-0.4
One hour access (0.3 mA shock)2.83.35.2-2.3-2.0-1.61.2-2.0-2.3-2.1-2.30.0-1.91.82.10.4-1.4
Compulsive drug intake0.40.42.0-0.6-0.1-0.50.7-0.0-0.40.10.3-0.50.00.1-1.00.61.4
One hour access (shock baseline)1.51.75.1-1.1-1.2-0.8-0.1-1.2-1.1-1.5-1.71.0-1.31.42.2-0.2-1.8
Social response proportion1.21.35.0-1.0-1.1-1.32.2-1.2-0.9-0.5-0.4-0.9-0.4-0.40.22.20.5
Social responses1.72.25.8-1.6-1.8-1.52.4-1.8-1.6-1.3-0.8-2.4-1.20.20.71.1-0.3
Social time4.05.38.3-2.3-2.6-1.62.2-2.6-2.7-2.8-2.2-2.9-2.92.31.8-0.1-1.6
Soleus weight3.510.219.23.73.64.4-3.54.03.43.53.21.03.4-2.6-2.9-2.31.0
Bone: stiffness0.40.63.60.70.60.6-1.10.50.70.3-0.21.90.1-0.60.9-0.30.0
Tibialis anterior weight1.44.911.52.62.52.2-3.42.72.42.41.81.31.9-0.4-1.7-2.70.8
Time to tail flick, vehicle, before self-admin0.90.92.6-0.8-1.0-0.71.2-1.4-0.8-0.9-1.00.3-0.60.31.21.6-0.7
Time to tail flick, vehicle, after self-admin0.10.10.50.0-0.0-0.10.4-0.30.50.1-0.00.40.2-0.5-0.20.7-0.2
Time to tail flick, test, before self-admin0.70.62.3-0.4-0.8-0.20.3-0.7-0.3-0.4-0.81.3-0.1-0.41.51.1-1.2
Time to tail flick, test, after self-admin0.50.52.1-0.3-0.9-0.10.5-0.8-0.6-0.7-1.00.3-0.6-0.21.40.6-1.1
Delta time to tail flick, vehicle, before/after SA0.30.31.10.60.30.9-0.70.50.50.20.3-0.50.2-0.5-0.5-1.1-0.7
Delta time to tail flick, test, before/after SA0.20.11.0-0.1-0.2-0.10.2-0.1-0.3-0.3-0.2-1.0-0.50.2-0.1-0.50.1
Tibia length0.00.10.80.10.50.3-0.20.20.10.20.10.90.2-0.1-0.20.50.3
Ambulatory time before self-admin0.50.51.40.90.60.5-0.40.70.90.80.80.31.0-1.2-0.30.0-0.1
Ambulatory time after self-admin0.50.62.60.70.41.0-0.70.40.00.10.4-1.50.1-0.80.2-1.6-0.4
Bone: tissue strength0.20.20.70.30.3-0.5-0.80.40.50.3-0.00.70.10.1-0.0-0.80.5
Total heroin consumption0.50.62.6-0.4-0.7-0.1-0.0-0.6-0.8-0.8-1.10.7-0.90.61.6-0.0-0.4
Bone: trabecular number2.43.88.42.22.22.7-2.92.12.01.70.82.11.8-2.1-0.1-1.6-0.9
Bone: trabecular spacing1.72.24.1-1.9-1.8-1.81.4-1.6-1.7-1.6-1.1-0.0-1.62.01.21.1-0.3
Bone: trabecular thickness0.70.93.70.90.41.9-1.10.50.50.30.0-0.30.2-1.10.0-1.2-1.6
Bone: trabecular tissue density1.92.75.4-1.3-1.9-0.70.9-1.6-1.7-1.9-1.6-2.3-2.01.71.2-1.1-1.9
Water consumed over 24 hours1.51.83.3-1.6-1.5-1.01.6-1.3-1.5-1.5-1.4-1.8-1.41.31.00.2-0.8
Number of responses in last shaping day1.11.12.50.81.00.30.20.71.01.31.20.31.6-1.4-1.21.21.3