Hub : Genes

Scube3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Scube3	0.02	0.01	1.1e-03	0.03	0.02	0.02	0.02	5.6e-04	4.2e-03	6.6e-03	4.3e-03
2	Brain	mRNA stability	Scube3	0.03	0.02	2.9e-03	0.02	0.02	0.02	0.01	4.7e-03	5.6e-03	1.1e-02	1.5e-02
3	PL	mRNA stability	Scube3	0.03	0.02	3.1e-04	0.04	0.04	0.03	0.03	9.5e-05	8.0e-05	1.7e-04	3.4e-04
4	Liver	gene expression	Scube3	0.46	0.1	0.0e+00	0.46	0.44	0.47	0.48	5.8e-57	3.5e-54	7.3e-59	6.9e-61
5	Brain	isoform ratio	XM_039098519.2	0.02	0.02	3.2e-03	0.03	0.03	0.03	0.03	4.1e-04	1.6e-03	8.8e-04	9.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.0	0.0	0.0	0.1	0.0	0.0	-0.1	-0.0
Area under the delay curve	0.1	0.1	0.3	0.1	0.4	0.2	-0.5	0.1
BMI with tail	2.4	8.3	10.6	3.3	3.1	-3.0	-2.7	2.2
BMI without tail	0.7	3.7	4.3	2.1	2.1	-2.1	-2.0	1.3
Body weight	1.5	6.6	10.6	2.0	2.2	-2.2	-3.0	3.3
Weight adjusted by age	0.1	0.3	0.4	-0.3	0.3	0.5	-0.7	0.7
Bone surface	0.1	0.1	0.3	-0.5	-0.5	0.4	0.1	-0.1
Bone volume	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.2	-0.0
Breakpoint value in progressive ratio session	0.7	1.3	1.9	1.2	0.9	-1.4	-0.9	1.1
Number of licking bursts	0.4	1.3	2.0	-1.0	-1.4	0.7	1.1	-1.2
Context. condit. distance diff. score	2.1	2.6	3.6	-1.9	-1.8	1.5	1.5	-1.2
Locomotion velocity, session 1	3.0	3.4	4.5	-2.0	-1.9	2.1	1.7	-1.4
Locomotion distance, session 1	2.0	2.6	3.3	-1.5	-1.5	1.6	1.8	-1.5
Locomotion velocity, session 2	0.9	1.1	1.3	-1.1	-1.1	0.8	1.0	-1.1
Locomotion distance, session 2	0.7	1.0	1.4	-1.2	-0.9	1.2	1.1	-0.7
Locomotion velocity, session 3	0.8	0.9	2.4	-0.7	-0.6	0.6	0.9	-1.6
Locomotion distance, session 3	1.4	1.6	2.3	-1.2	-1.0	1.2	1.4	-1.5
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	-0.3	-0.5	-0.0	-0.1	-0.4
Stereotopy head waving duration, day 3	0.3	0.4	0.9	-0.7	-0.6	0.6	0.3	-0.9
Locomotion velocity, session 7	0.6	0.7	1.5	-1.0	-0.2	1.2	0.7	-0.6
Locomotion distance, session 7	1.5	1.9	3.6	-1.7	-0.9	1.9	1.3	-0.8
Stereotopy head waving bouts, day 7	0.3	0.3	1.1	-0.3	-0.3	0.2	0.5	-1.1
Stereotopy head waving duration, day 7	0.1	0.1	0.3	0.2	0.0	-0.2	0.1	-0.6
Locomotion velocity, session 8	2.3	2.8	4.3	-2.1	-1.9	1.7	1.4	-1.1
Locomotion distance, session 8	2.5	3.6	4.7	-2.2	-2.0	1.9	1.9	-1.6
Degree of sensitization distance	0.3	0.3	0.8	0.1	0.3	-0.1	-0.8	0.9
Degree of sensitization stereotypy	0.4	0.5	1.3	-0.4	-0.4	0.4	0.8	-1.1
Conditioned locomotion	1.7	2.0	2.5	1.2	1.1	-1.5	-1.6	1.5
Cocaine response after cond. corrected	0.5	0.8	1.3	1.1	0.8	-1.1	-0.9	0.2
Cocaine response after cond. not corrected	0.1	0.2	0.3	0.4	0.2	-0.6	-0.4	-0.3
Cocaine response before conditioning	1.0	1.2	2.0	-1.4	-1.1	1.2	0.8	-0.8
Saline control response	3.2	4.4	5.8	2.2	2.4	-2.1	-2.2	1.3
Bone: connectivity density	0.0	0.0	0.1	-0.0	0.0	0.1	-0.2	0.4
Bone: cortical apparent density	0.8	1.2	1.8	1.3	1.1	-1.3	-1.0	0.6
Bone: cortical area	0.0	0.1	0.1	-0.2	-0.3	0.3	0.3	-0.2
Bone: cortical porosity	1.5	1.6	2.3	-1.4	-0.9	1.5	1.1	-1.3
Bone: cortical porosity	1.9	2.0	3.4	-1.6	-1.0	1.8	1.1	-1.4
Bone: cortical thickness	0.1	0.1	0.4	0.6	0.3	-0.2	0.2	-0.3
Bone: cortical thickness	1.9	2.3	3.6	1.9	1.7	-1.6	-1.3	0.8
Bone: cortical tissue density	0.7	1.1	1.5	1.2	1.1	-1.2	-0.9	0.6
Condit. Reinf. active minus inactive responses	0.2	0.3	0.8	-0.7	-0.0	0.9	0.2	-0.3
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.0	0.7	1.0	-0.7	-0.9	0.7
Condit. Reinf. active responses	0.2	0.2	0.4	-0.1	0.6	0.3	-0.4	0.6
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.1	0.5	0.1	-0.3	0.5
Incentive salience index mean	0.6	0.7	1.4	-1.2	-0.7	1.2	0.6	-0.3
Condit. Reinf. lever presses	0.6	0.9	1.4	-1.2	-1.1	1.1	0.8	-0.0
Condit. Reinf. active minus inactive responses	0.4	0.6	1.1	-1.1	-0.8	1.0	0.7	0.0
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.6	-0.8	-0.5	0.7	0.5	-0.0
Condit. Reinf. active responses	0.5	0.7	1.0	-1.0	-0.9	1.0	0.7	-0.0
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.2
Condit. Reinf. lever presses	1.1	1.6	2.6	-1.6	-1.1	1.6	1.3	-0.2
Condit. Reinf. lever reinforcers received	0.9	1.2	1.8	-1.3	-1.1	1.4	1.1	-0.3
Conditioned reinforcement - actives	0.0	0.2	0.4	-0.7	-0.3	0.5	0.2	0.2
Conditioned reinforcement - inactives	0.2	0.5	0.9	-0.7	-0.5	0.8	0.5	-1.0
Conditioned locomotion	0.2	0.3	0.6	-0.3	0.5	0.5	-0.7	0.4
Patch foraging indifference point 0 sec	0.5	1.4	2.3	1.5	1.2	-1.3	-1.0	1.0
Patch foraging indifference point AUC	0.6	1.5	2.3	-1.2	-1.2	1.0	1.2	-1.5
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.2	-0.2	0.4	0.0	-0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.3	-0.2	0.5	0.1	-0.2
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	-0.6	-0.1	0.8	0.1	-0.3
Delay disc. indifference point, 24s delay	0.2	0.3	0.6	0.1	0.8	0.3	-0.8	0.6
Delay disc. indifference point, 4s delay	0.3	0.3	0.6	0.5	0.6	-0.4	-0.8	0.4
Delay disc. indifference point, 8s delay	0.2	0.3	0.6	0.2	0.6	0.0	-0.8	0.5
Indifference point function ln k	0.2	0.7	1.1	-1.0	-1.0	0.7	0.8	-0.2
Indifference point function log k	0.2	0.7	1.1	-1.0	-1.0	0.7	0.8	-0.2
Patch foraging total patch changes 0 sec	0.5	1.4	2.3	1.5	1.2	-1.2	-0.9	1.0
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.5	-0.1	-0.4	0.3	-0.2
Patch foraging total patch changes 18 sec	0.8	2.0	3.2	1.8	1.5	-1.6	-1.1	0.7
Patch foraging total patch changes 24 sec	0.2	0.6	1.5	1.2	0.9	-0.7	-0.5	0.4
Patch foraging total patch changes 6 sec	0.6	1.0	2.0	1.4	1.2	-1.0	-0.8	-0.4
Patch foraging time to switch 0 sec	1.7	6.5	8.0	2.8	2.4	-2.5	-2.4	2.6
Patch foraging water rate 0 sec	0.2	0.8	1.1	-1.0	-0.7	0.9	0.9	-0.9
Patch foraging water rate 12 sec	0.2	0.6	1.8	-0.5	-0.6	0.4	0.8	-1.3
Patch foraging water rate 18 sec	0.0	0.1	0.2	0.3	0.5	-0.2	-0.4	0.0
Patch foraging water rate 24 sec	0.3	0.4	0.9	-0.3	-0.6	0.1	0.8	-1.0
Patch foraging water rate 6 sec	0.4	0.6	1.1	-0.5	-0.8	0.4	0.8	-1.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.9	0.6	-0.1	-0.9	-0.1	-0.0
Distance traveled before self-admin	0.1	0.2	0.8	0.4	0.1	-0.9	-0.3	0.3
Distance traveled after self-admin	0.3	0.6	1.5	0.8	0.2	-1.2	-0.6	0.6
Extensor digitorum longus weight	0.5	2.1	3.8	-1.5	-1.9	1.3	1.3	-0.9
Bone: elastic displacement	0.8	1.0	2.4	-0.8	-0.4	1.1	0.7	-1.5
Bone: elastic work	0.1	0.2	0.6	-0.0	0.4	0.3	-0.1	-0.8
Bone: endosteal estimation	0.4	1.0	2.6	0.4	0.3	-0.7	-1.4	1.6
Bone: endosteal perimeter	0.2	0.6	1.8	0.1	-0.0	-0.5	-0.8	1.4
Epididymis fat weight	3.9	19.7	28.3	5.3	5.2	-4.7	-3.9	2.4
Delta time in closed arm before/after self-admin	0.7	0.7	1.3	0.8	1.1	-0.7	-0.9	0.5
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.2	-0.4	0.2	0.3	-0.0
Diff in mean of infusions in LGA sessions	0.2	0.3	0.4	0.6	0.7	-0.6	-0.2	0.4
Delay discount exponential model param	0.1	0.1	0.2	-0.0	-0.3	-0.2	0.4	-0.0
Extinction: sum of active levers before priming	0.0	0.1	0.2	-0.3	-0.2	-0.0	0.5	0.0
Active lever presses in extinction session 6	0.5	0.5	1.5	0.4	1.2	-0.1	-0.8	0.6
Bone: final force	3.5	5.7	6.6	2.6	2.4	-2.4	-2.4	2.1
Bone: final moment	2.4	3.9	4.4	2.1	2.1	-1.9	-2.0	1.7
Food consumed during 24 hour testing period	1.6	3.3	4.1	1.6	1.5	-1.8	-2.0	2.0
Glucose	2.6	4.1	6.2	-2.5	-2.2	2.4	1.8	-0.7
Heart weight	1.8	2.9	4.8	-1.9	-1.4	2.2	1.6	-1.2
Delay discount hyperbolic model param	0.1	0.1	0.2	0.2	-0.1	-0.4	0.2	0.3
Intermittent access intake day 1-15 change	0.3	1.4	2.2	1.5	0.9	-1.4	-1.1	0.9
Intermittent access intake escalation	0.4	2.1	3.2	1.8	1.3	-1.6	-1.4	1.1
Intermittent access intake escalation 2	0.0	0.1	0.1	0.1	0.1	-0.2	-0.3	0.4
Intermitt. access day 1 inactive lever presses	0.2	2.1	4.1	-0.6	-2.0	0.3	1.7	-1.8
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.2	0.1	-0.4	-0.3	-0.0	0.2
Intermitt. access escalation Index	0.2	0.5	0.9	0.1	-0.9	-0.2	0.9	-0.9
Intermittent access day 1 total infusions	0.9	2.5	4.4	-2.1	-1.3	2.1	1.3	-0.7
Intermittent access day 15 total infusions	0.0	0.0	0.1	-0.1	-0.0	0.4	-0.0	0.0
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	-0.4	-0.2	0.6	0.1	-0.0
Intermittent access total infusions	0.5	0.6	1.3	-1.0	-0.7	1.1	0.5	-0.3
Intermittent access day 1 locomotion	0.1	0.2	0.3	-0.5	-0.4	0.5	0.1	-0.1
Intermittent access day 15 total locomotion	0.5	2.1	3.5	1.1	1.4	-1.0	-1.9	1.7
Intermittent access total locomotion	0.2	0.3	0.7	0.1	0.4	0.0	-0.8	0.7
Intermittent access standard deviation	0.4	2.1	3.1	1.6	1.3	-1.8	-1.5	1.1
Left kidney weight	0.5	3.7	6.8	1.7	1.3	-1.8	-2.0	2.6
Right kidney weight	0.9	6.3	9.2	2.3	2.0	-2.4	-2.8	3.0
Cocaine induced anxiety	0.1	0.3	0.7	-0.2	-0.8	-0.0	0.5	-0.6
Post-drug Anxiety	0.1	0.1	0.2	0.3	0.1	-0.5	-0.2	-0.2
Baseline Anxiety	0.9	1.6	3.0	1.2	1.7	-1.0	-1.3	0.8
Tail length	0.2	1.2	2.4	-1.6	-1.5	1.0	0.4	-0.2
Length with tail	0.2	1.0	1.7	-1.3	-1.0	0.8	-0.4	1.2
Length without tail	0.4	1.9	5.0	0.5	1.0	-0.6	-1.7	2.2
Times rat made contact with spout	0.1	0.1	0.4	0.1	0.2	0.1	0.2	-0.6
Lifetime Intake	0.2	0.3	0.8	-0.7	-0.3	0.9	0.2	-0.1
Liver weight, left	0.4	0.8	2.3	0.4	0.2	-0.7	-1.0	1.5
Liver weight, right	0.3	0.5	1.4	-1.0	-1.2	0.4	0.1	-0.3
Locomotor activity	0.2	0.3	0.8	0.2	-0.9	-0.4	0.4	-0.7
Locomotor testing distance	0.2	0.5	1.2	1.1	0.1	-1.1	-0.3	0.2
Locomotor testing rearing	0.4	1.6	2.5	1.5	0.9	-1.6	-1.2	1.1
Locomotion in novel chamber	0.2	0.3	0.5	-0.6	-0.5	0.4	0.7	-0.1
Locomotion in novel chamber post-restriction	1.0	2.9	3.7	1.5	1.9	-1.5	-1.8	1.7
Fecal boli incidents, locomotor time 1	0.2	0.6	1.4	0.4	0.8	-0.4	-0.9	1.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.5	0.4	-0.6	-0.5	0.0
Time >=10cm from walls, locomotor time 1	3.9	4.9	6.4	2.3	1.9	-2.5	-2.2	2.1
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.2	-0.5	-0.3	0.2	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.1	-0.4	-0.2	0.0	0.3
Rest time, locomotor task time 1	0.8	1.3	2.1	-1.4	-0.9	1.3	0.9	-1.1
Distance moved, locomotor task time 1	0.4	1.2	1.4	1.1	1.1	-1.2	-0.9	1.1
Vertical activity count, locomotor time 1	0.8	5.4	6.3	2.5	2.2	-2.4	-2.2	2.3
Time >=10cm from walls, locomotor time 2	2.0	5.7	7.3	2.2	2.7	-1.9	-2.6	2.4
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.0	-0.1	-0.3	-0.2	0.0
Total resting periods, locomotor time 2	0.1	0.3	0.4	-0.5	-0.7	0.3	0.3	-0.6
Rest time, locomotor task time 2	0.4	0.6	1.1	-0.7	-1.0	0.3	0.8	-0.9
Distance moved, locomotor task time 2	3.1	4.1	6.0	1.7	2.5	-1.4	-2.1	2.2
Vertical activity count, locomotor time 2	1.4	3.4	4.9	1.6	2.2	-1.2	-2.0	2.0
Light reinforcement 1	0.9	4.1	6.9	2.4	1.7	-2.6	-1.8	1.2
Light reinforcement 2	1.3	2.9	3.9	1.7	1.7	-2.0	-1.8	1.4
Bone: marrow area	0.5	1.3	3.2	0.5	0.5	-0.9	-1.5	1.8
Bone: maximum diameter	0.6	1.2	2.0	-1.3	-1.4	1.1	0.8	-0.7
Bone: maximum force	0.5	1.1	1.3	1.1	1.0	-0.9	-1.1	1.1
Bone: maximum moment	0.2	0.4	0.6	0.6	0.7	-0.4	-0.7	0.8
Mean time between licks in bursts	1.0	6.3	9.3	-2.9	-3.0	2.3	2.4	-1.7
Mean num. licks in bursts	0.2	0.5	1.4	0.7	1.2	-0.4	-0.7	0.4
Cd content in liver	1.4	1.5	2.2	1.0	1.5	-0.7	-1.4	1.3
Co content in liver	5.6	6.5	10.5	2.3	2.6	-2.0	-2.5	3.2
Cu content in liver	0.1	0.2	0.4	0.4	0.4	-0.1	0.3	-0.7
Fe content in liver	0.4	0.4	0.7	0.7	0.8	-0.7	-0.7	0.3
K content in liver	2.3	2.3	2.9	-1.7	-1.7	1.5	1.5	-1.0
Mg content in liver	2.4	2.6	3.7	-1.9	-1.9	1.5	1.6	-1.0
Mn content in liver	2.7	3.0	5.0	-2.1	-2.2	1.6	1.6	-0.8
Na content in liver	0.2	0.2	0.5	-0.2	-0.4	0.1	0.7	-0.7
Rb content in liver	0.2	0.3	0.4	0.3	0.6	-0.2	-0.6	0.7
Se content in liver	6.7	8.0	9.3	-3.1	-3.0	2.7	2.7	-2.7
Sr content in liver	0.3	0.2	0.5	0.2	0.7	0.0	-0.5	0.7
Zn content in liver	1.3	1.5	2.3	-1.5	-1.3	1.4	1.1	-0.5
Bone: minimum diameter	0.2	0.3	1.3	-0.0	-0.2	-0.2	-0.5	1.2
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.0	0.4	0.2	0.1	0.2
Time in novel zone, hab. session 1	0.1	0.1	0.7	-0.1	-0.1	-0.0	0.0	-0.8
Total zone transitions, hab. session 1	1.8	2.6	3.8	-1.3	-1.7	1.3	1.9	-1.7
Total locomotion distance, hab. session 1	2.1	3.0	4.3	-1.6	-1.8	1.5	2.1	-1.5
Locomotion velocity, hab. session 1	2.2	3.1	4.6	-1.6	-2.1	1.6	2.1	-1.3
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.2	-0.4	-0.5	0.3	-0.0
Time in novel zone, hab. session 2	0.3	0.3	0.7	0.2	0.8	0.2	-0.8	0.1
Total zone transitions, hab. session 2	0.4	0.5	0.9	-0.4	-0.8	0.1	0.9	-0.8
Total locomotion distance, hab. session 2	1.5	2.0	3.3	-0.9	-1.7	0.7	1.8	-1.6
Locomotion velocity, hab. session 2	2.2	3.0	4.8	-1.3	-2.1	1.0	2.2	-1.8
Novel to familiar place preference ratio	0.2	0.2	1.2	0.0	0.2	0.2	0.0	-1.1
Novelty place preference	0.3	0.3	1.5	-0.1	0.0	0.3	0.1	-1.2
Time in novel zone, NPP test	0.3	0.3	1.4	-0.1	0.2	0.3	0.0	-1.2
Total zone transitions, NPP test	1.8	2.6	3.3	-1.6	-1.5	1.5	1.8	-1.7
Total locomotion distance, NPP test	0.6	0.8	1.1	-0.8	-0.7	1.0	1.0	-0.9
Locomotion velocity, NPP test	0.7	1.0	1.6	-0.8	-0.8	0.9	1.3	-1.1
Intraocular pressure	0.2	0.3	1.3	0.2	0.2	-0.3	-0.5	1.1
Delta distance traveled before/after self-admin	0.1	0.1	0.3	0.2	0.2	-0.1	-0.3	0.6
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.3	0.2	-0.3	-0.4	0.5
Parametrial fat weight	4.1	9.7	11.5	3.3	2.6	-3.4	-2.9	3.2
Pavlov. Cond. lever latency	6.4	8.2	10.2	3.1	2.9	-3.2	-2.7	2.3
Pavlov. Cond. magazine entry latency	4.8	6.2	7.9	-2.8	-2.5	2.6	2.3	-2.2
Pavlov. Cond. change in total contacts	1.2	1.3	2.1	-1.5	-1.2	1.4	0.9	-0.5
Pavlov. Cond. index score	6.1	7.7	9.7	-3.1	-2.8	3.1	2.6	-2.2
Pavlov. Cond. latency score	5.7	7.3	9.0	-3.0	-2.8	3.0	2.5	-2.1
Pavlov. Cond. lever contacts	4.3	5.2	6.9	-2.5	-2.3	2.6	2.1	-1.7
Pavlov. Cond. magazine entry number	4.2	5.4	6.7	2.6	2.3	-2.4	-2.2	2.0
Pavlov. Cond. intertrial magazine entries	1.3	1.6	2.7	1.2	1.7	-0.8	-1.5	1.0
Pavlov. Cond. lever-magazine prob. diff.	6.1	7.6	9.6	-3.1	-2.7	3.1	2.6	-2.2
Pavlov. Cond. response bias	6.4	8.0	9.8	-3.1	-2.8	3.0	2.6	-2.5
Pavlov. Cond. lever latency	0.7	1.0	2.0	1.2	0.7	-1.4	-1.0	0.2
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	-0.1	0.4	0.2	-0.5	0.7
Pavlov. Cond. change in total contacts	0.1	0.3	0.6	-0.6	-0.3	0.8	0.4	0.6
Pavlov. Cond. index score	0.3	0.4	1.0	-0.9	-0.3	1.0	0.4	0.4
Pavlov. Cond. latency score	0.2	0.3	0.7	-0.7	-0.3	0.9	0.3	0.5
Pavlov. Cond. lever contacts	0.4	0.6	1.3	-0.9	-0.4	1.2	0.8	-0.1
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	-0.4	-0.7	0.2	0.7	-1.1
Pavlov. Cond. intertrial magazine entries	0.5	1.0	2.3	-0.9	-1.5	0.4	1.0	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.7	-0.7	-0.2	0.9	0.3	0.5
Pavlov. Cond. response bias	0.6	0.8	2.0	-1.2	-0.5	1.4	0.7	-0.1
Time in closed arm before self-admin	0.0	0.0	0.0	-0.0	-0.0	0.2	-0.0	0.1
Time in closed arm after self-admin	0.1	0.1	0.3	-0.0	0.3	0.5	0.1	-0.3
Time in open arm before self-admin	0.7	0.9	1.2	-1.1	-0.7	0.9	0.9	-1.0
Time in open arm after self-admin	0.5	0.6	0.9	-0.9	-0.9	0.6	0.7	-0.6
Bone: periosteal estimation	0.1	0.3	0.6	0.2	0.0	-0.4	-0.7	0.8
Bone: periosteal perimeter	0.1	0.2	0.8	0.1	-0.1	-0.3	-0.3	0.9
Bone: post-yield work	0.2	0.3	1.3	-0.2	-0.3	0.3	-0.2	1.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.4	0.2	0.5	-0.2	0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.4	-0.6	0.0	0.6	-0.0	-0.0
Progressive ratio test 1 inactive lever presses	0.3	0.8	1.0	1.0	0.8	-1.0	-0.8	0.8
Progressive ratio test 2 active lever presses	0.0	0.1	0.2	-0.2	-0.0	0.4	0.0	-0.3
Progressive ratio test 2 breakpoint	0.0	0.1	0.2	-0.3	-0.1	0.4	0.0	-0.2
Progressive ratio test 2 inactive lever presses	0.2	0.7	1.2	-1.0	-0.6	1.1	0.5	-0.7
Incentive Sensitization - Responses	0.3	0.8	1.5	-0.6	-1.2	0.6	1.0	-0.8
Incentive Sensitization - Breakpoint	0.2	0.5	1.0	-0.4	-1.0	0.4	0.8	-0.6
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.4	-0.2	0.5	0.5	-0.3
Progressive ratio	1.5	4.5	5.7	2.2	2.2	-2.4	-2.2	1.6
Food seeking constrained by brief footshock	0.3	0.4	0.9	0.3	1.0	-0.1	-0.7	0.7
Seeking ratio, punishment vs. effort	1.3	2.9	4.0	-1.7	-1.5	2.0	1.8	-1.4
Retroperitoneal fat weight	0.3	1.4	1.9	1.1	1.2	-1.3	-1.4	1.0
Reaction time number correct	0.7	2.6	3.5	1.8	1.9	-1.8	-1.5	0.8
Reaction time mean minus median	0.2	1.3	2.5	-1.5	-1.6	1.2	0.7	0.3
Reaction time mean minus median AUC	0.2	1.1	2.0	-1.4	-1.1	1.4	0.4	0.4
Reaction time num false alarms	0.7	1.2	2.7	-1.1	-1.6	0.6	1.3	-0.3
Reaction time num false alarms AUC	0.9	2.1	4.0	-1.5	-2.0	1.0	1.7	-0.7
Reaction time trials correct on left	0.7	2.6	3.5	1.8	1.9	-1.8	-1.5	0.8
Reaction time trials on left	0.8	2.6	3.5	1.8	1.9	-1.8	-1.5	0.9
Reaction time mean	0.2	0.5	1.3	-0.6	-0.5	0.6	-0.1	1.1
Reaction time mean AUC	0.2	0.5	2.0	-0.4	-0.2	0.4	-0.5	1.4
Median of all reaction times	0.3	0.4	1.9	-0.1	0.1	0.2	-0.5	1.4
Reaction time omissions	0.1	0.2	0.4	-0.4	-0.6	-0.1	0.2	0.6
Reaction time false alarm rate	3.9	5.4	8.4	-2.5	-2.9	2.1	2.5	-1.3
Reaction time premature initiation rate	0.1	0.1	0.5	0.1	-0.1	-0.2	0.0	0.7
Reaction time premature initiations	0.5	1.5	1.8	1.3	1.1	-1.3	-1.0	1.3
Std. dev. reaction times	0.5	1.6	2.7	-1.6	-1.6	1.4	0.7	0.4
Reaction time trials completed	0.8	2.6	3.5	1.8	1.9	-1.8	-1.5	0.9
Reaction time trials AUC	0.8	2.8	3.7	1.9	1.9	-1.9	-1.6	0.9
Run reversals in cocaine runway, females	0.1	0.2	0.3	-0.1	0.4	0.4	-0.4	0.6
Run reversals in cocaine runway, males	1.4	1.6	2.2	-1.4	-1.5	1.3	0.9	-1.1
Latency to leave start box in cocaine runway	0.3	0.4	0.6	-0.6	-0.6	0.6	0.8	-0.8
Latency to leave start box in cocaine runway, F	0.2	0.3	0.4	-0.5	-0.5	0.4	0.7	-0.6
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.1	-0.2	0.1	0.2	-0.3
Std. dev. time between licks in bursts	2.7	5.1	7.1	-2.6	-2.7	2.0	2.2	-1.6
Total sessions with >9 infusions	0.2	0.3	0.5	-0.6	-0.5	0.7	0.3	-0.3
Short access day 1 total inactive lever presses	0.2	0.5	1.2	-0.9	-0.5	1.1	0.3	0.1
Short access day 10 total inactive lever presses	0.1	0.8	1.2	0.6	-1.1	-0.9	0.8	-0.9
Short access day 1 total infusions	0.5	1.0	1.7	-1.3	-1.0	1.2	0.8	-0.3
Short access day 10 total infusions	0.0	0.1	0.1	-0.2	-0.4	0.2	0.1	0.2
Short access total infusions	0.2	0.2	0.5	-0.7	-0.3	0.7	0.2	0.2
Short access day 1 locomotion	0.3	0.5	1.3	-0.3	-1.2	0.3	0.8	-0.8
Short access day 10 total locomotion	0.1	0.3	1.0	-0.2	-1.0	-0.1	0.5	-0.3
Short access total locomotion	0.0	0.1	0.2	0.0	-0.5	-0.1	0.0	-0.1
One hour access (0.3 mA shock)	2.5	3.0	3.7	-1.4	-1.9	1.4	1.9	-1.8
Compulsive drug intake	0.7	1.0	2.3	-0.5	-1.5	0.3	1.3	-0.9
One hour access (shock baseline)	0.2	0.5	1.2	-0.9	-0.3	1.1	0.4	-0.6
Social response proportion	0.1	0.2	0.2	-0.5	-0.3	0.3	0.3	-0.5
Social responses	0.0	0.1	0.2	0.0	-0.4	-0.2	0.3	-0.1
Social time	1.0	1.6	4.1	-1.0	-2.0	0.2	1.3	-1.1
Soleus weight	1.8	5.4	8.7	-2.7	-2.9	2.2	1.7	-1.8
Bone: stiffness	1.0	1.8	2.9	1.3	1.1	-1.3	-1.1	1.7
Tibialis anterior weight	0.1	0.2	0.4	-0.1	-0.6	0.1	0.6	-0.5
Time to tail flick, vehicle, before self-admin	0.7	0.8	2.3	1.2	0.3	-1.5	-0.5	0.3
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.1	-0.2	0.2	0.1	-0.0
Time to tail flick, test, before self-admin	0.3	0.3	0.8	0.1	-0.6	-0.2	0.7	-0.9
Time to tail flick, test, after self-admin	0.4	0.4	0.6	-0.5	-0.7	0.7	0.5	-0.7
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.4	-0.7	0.1	1.2	0.2	-0.3
Delta time to tail flick, test, before/after SA	0.2	0.3	0.5	0.5	0.5	-0.3	-0.7	0.5
Tibia length	0.4	1.2	2.1	0.7	0.4	-1.2	-1.4	1.5
Ambulatory time before self-admin	0.0	0.1	0.2	0.1	-0.1	-0.5	0.1	-0.0
Ambulatory time after self-admin	0.1	0.2	0.7	0.4	-0.0	-0.8	-0.3	0.3
Bone: tissue strength	0.4	0.5	0.8	0.7	0.9	-0.4	-0.7	0.6
Total heroin consumption	0.1	0.1	0.3	0.2	-0.2	-0.6	0.3	0.2
Bone: trabecular number	0.0	0.0	0.1	-0.0	-0.2	0.2	0.1	-0.1
Bone: trabecular spacing	0.6	0.9	1.0	0.8	0.9	-0.9	-1.0	1.0
Bone: trabecular thickness	0.2	0.2	0.4	0.4	0.5	-0.3	-0.7	0.5
Bone: trabecular tissue density	0.5	0.8	1.2	-1.1	-0.9	1.1	0.8	-0.7
Water consumed over 24 hours	0.0	0.1	0.2	-0.1	-0.2	0.1	0.1	-0.5
Number of responses in last shaping day	3.4	4.4	6.3	-2.5	-1.7	2.5	1.8	-1.9