Hub : Genes

Scube3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb mRNA stability Scube3 0.24 0.16 2.4e-03 0.04 0.07 0.07 0.05 3.6e-02 9.9e-03 7.8e-03 2.3e-02
2 Brain alternative TSS XM_039098519.1 0.03 0.02 9.9e-04 0.02 0.02 0.01 0.01 4.3e-03 1.2e-02 2.7e-02 2.0e-02
3 Brain alternative TSS XM_039098519.1 0.03 0.02 1.1e-03 0.02 0.01 0.01 0.01 4.9e-03 1.4e-02 2.7e-02 2.3e-02
4 Brain isoform ratio XM_039098519.1 0.04 0.02 2.3e-04 0.03 0.03 0.03 0.03 9.7e-04 1.8e-03 1.8e-03 1.8e-03
5 PL alternative TSS XM_008772805.3 0.03 0.02 8.8e-03 0.02 0 0 0 6.9e-03 1.8e-01 2.3e-01 1.1e-01
6 PL alternative TSS XM_008772805.3 0.03 0.02 7.5e-03 0.02 0 0 0 5.9e-03 1.4e-01 2.0e-01 9.1e-02
7 Liver mRNA stability Scube3 0.25 0.08 0.0e+00 0.3 0.26 0.28 0.29 4.4e-33 5.7e-29 6.6e-31 1.5e-32
8 Liver isoform ratio XM_017601593.2 0.05 0.03 4.3e-06 0.04 0.04 0.04 0.02 1.1e-05 5.9e-05 2.3e-05 1.3e-03
9 Brain alternative TSS XM_008772805.3 0.04 0.03 2.0e-04 0.03 0.04 0.02 0.03 7.7e-04 2.6e-04 3.6e-03 1.0e-03
10 Brain alternative TSS XM_008772805.3 0.04 0.03 1.9e-04 0.03 0.04 0.02 0.03 7.2e-04 2.4e-04 3.4e-03 8.7e-04
11 Liver gene expression Scube3 0.47 0.11 0.0e+00 0.45 0.45 0.47 0.47 2.1e-55 1.6e-54 7.1e-59 1.1e-58
12 Liver isoform ratio XM_008772806.3 0.05 0.03 1.2e-05 0.04 0.03 0.02 0.03 2.6e-05 2.1e-04 1.7e-03 1.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.10.4-0.60.10.10.10.20.2-0.00.0-0.3-0.3-0.3-0.5
Area under the delay curve0.10.10.4-0.20.20.20.2-0.3-0.30.4-0.10.00.10.60.6
BMI with tail2.37.59.53.12.92.92.9-2.8-2.82.9-2.92.82.92.11.2
BMI without tail0.40.82.91.70.80.80.8-0.6-0.60.6-0.71.11.10.40.5
Body weight1.66.715.71.82.32.32.3-2.1-2.12.4-2.52.82.82.94.0
Weight adjusted by age0.30.41.90.20.40.40.4-0.6-0.60.7-0.20.10.10.91.4
Bone surface0.30.52.8-1.7-0.6-0.6-0.60.70.7-0.60.7-0.6-0.6-0.30.1
Bone volume0.00.10.7-0.9-0.0-0.0-0.00.30.3-0.10.2-0.2-0.2-0.10.1
Breakpoint value in progressive ratio session0.60.70.80.50.90.90.9-0.9-0.90.7-0.90.80.80.70.7
Number of licking bursts1.31.52.2-1.4-1.2-1.2-1.21.51.5-1.21.2-1.0-1.0-1.3-1.0
Context. condit. distance diff. score2.93.55.1-2.3-2.1-2.1-2.11.81.8-2.02.0-1.8-1.8-1.4-0.9
Locomotion velocity, session 13.13.33.7-1.3-1.9-1.9-1.91.81.8-1.91.9-1.9-1.9-1.9-1.7
Locomotion distance, session 12.22.85.6-1.1-1.6-1.6-1.61.31.3-1.41.7-1.7-1.7-2.1-2.4
Locomotion velocity, session 21.21.43.1-1.8-1.3-1.3-1.31.11.1-1.21.3-1.0-1.0-0.9-0.6
Locomotion distance, session 20.81.11.4-1.2-1.1-1.1-1.10.80.8-1.01.1-1.2-1.2-0.9-1.0
Locomotion velocity, session 30.50.51.00.3-0.8-0.8-0.80.70.7-0.80.9-0.3-0.3-1.0-0.9
Locomotion distance, session 31.41.62.80.3-1.3-1.3-1.31.11.1-1.21.3-1.0-1.0-1.6-1.7
Stereotopy head waving bouts, day 30.20.31.0-1.0-0.4-0.4-0.40.50.5-0.50.50.00.00.20.9
Stereotopy head waving duration, day 30.30.41.4-1.2-0.6-0.6-0.60.50.5-0.70.7-0.6-0.6-0.20.2
Locomotion velocity, session 70.40.40.6-0.0-0.8-0.8-0.80.20.2-0.50.8-0.8-0.8-0.5-0.5
Locomotion distance, session 71.41.82.5-1.1-1.5-1.5-1.51.01.0-1.21.5-1.6-1.6-1.1-1.1
Stereotopy head waving bouts, day 70.20.31.21.1-0.3-0.3-0.30.40.4-0.60.4-0.1-0.1-0.7-0.6
Stereotopy head waving duration, day 70.20.22.11.40.20.20.2-0.1-0.10.0-0.20.50.5-0.10.0
Locomotion velocity, session 83.23.87.3-2.7-2.2-2.2-2.21.91.9-2.02.1-1.8-1.8-1.2-0.4
Locomotion distance, session 83.04.45.8-2.4-2.4-2.4-2.41.91.9-2.12.3-2.0-2.0-1.7-1.3
Degree of sensitization distance0.60.63.5-1.90.10.10.1-0.3-0.30.4-0.1-0.1-0.11.11.4
Degree of sensitization stereotypy0.40.41.51.2-0.4-0.4-0.40.40.4-0.60.4-0.2-0.2-0.9-1.1
Conditioned locomotion1.41.64.7-0.21.11.11.1-0.9-0.91.0-1.21.41.41.72.2
Cocaine response after cond. corrected0.60.61.00.30.70.70.7-0.8-0.80.8-0.81.01.00.90.8
Cocaine response after cond. not corrected0.10.10.5-0.20.00.00.0-0.2-0.20.1-0.10.40.40.40.7
Cocaine response before conditioning1.01.31.8-1.1-1.3-1.3-1.31.11.1-1.21.3-1.1-1.1-0.8-0.1
Saline control response4.25.66.52.12.52.52.5-2.5-2.52.4-2.52.32.32.31.7
Bone: connectivity density0.10.11.2-1.1-0.0-0.0-0.00.10.1-0.10.1-0.4-0.4-0.1-0.2
Bone: cortical apparent density1.11.43.11.81.21.21.2-1.2-1.21.2-1.21.21.21.00.6
Bone: cortical area0.00.00.1-0.10.00.00.00.20.20.00.1-0.0-0.0-0.3-0.2
Bone: cortical porosity0.80.91.1-0.1-0.9-0.9-0.91.01.0-0.80.9-1.0-1.0-1.0-1.1
Bone: cortical porosity1.01.01.6-0.5-1.0-1.0-1.01.11.1-0.91.0-1.2-1.2-1.0-0.8
Bone: cortical thickness0.40.72.51.60.80.80.8-0.5-0.50.8-0.80.50.5-0.4-1.1
Bone: cortical thickness2.02.33.21.11.81.81.8-1.6-1.61.8-1.61.51.51.10.3
Bone: cortical tissue density1.01.32.51.61.21.21.2-1.1-1.11.1-1.11.11.11.00.7
Condit. Reinf. active minus inactive responses0.20.20.8-0.9-0.3-0.3-0.30.20.2-0.10.4-0.8-0.8-0.1-0.3
Condit. Reinf. active-inactive response ratio0.60.60.80.50.90.90.9-0.9-0.90.9-0.90.60.60.80.7
Condit. Reinf. active responses0.10.10.2-0.30.30.30.3-0.4-0.40.5-0.2-0.2-0.20.40.1
Condit. Reinf. inactive responses0.20.20.40.10.60.60.6-0.5-0.50.6-0.30.10.10.4-0.1
Incentive salience index mean0.70.81.8-1.3-0.9-0.9-0.90.80.8-0.70.9-1.1-1.1-0.6-0.4
Condit. Reinf. lever presses0.81.12.7-1.6-1.1-1.1-1.11.01.0-1.01.1-1.1-1.1-0.9-0.5
Condit. Reinf. active minus inactive responses0.81.01.9-1.4-1.1-1.1-1.10.80.8-0.91.1-1.2-1.2-0.5-0.3
Condit. Reinf. active-inactive response ratio0.40.50.7-0.8-0.8-0.8-0.80.50.5-0.70.8-0.8-0.8-0.20.1
Condit. Reinf. active responses0.81.13.2-1.8-1.0-1.0-1.00.90.9-0.91.1-1.1-1.1-0.6-0.5
Condit. Reinf. inactive responses0.10.10.8-0.90.00.00.00.00.00.20.00.10.10.1-0.0
Condit. Reinf. lever presses1.11.52.8-0.9-1.2-1.2-1.21.01.0-1.21.1-1.7-1.7-1.1-1.3
Condit. Reinf. lever reinforcers received1.31.83.6-1.9-1.3-1.3-1.31.21.2-1.21.4-1.5-1.5-1.0-0.9
Conditioned reinforcement - actives0.10.10.2-0.4-0.1-0.1-0.10.40.4-0.40.1-0.4-0.4-0.3-0.1
Conditioned reinforcement - inactives0.30.30.60.3-0.3-0.3-0.30.70.7-0.70.3-0.5-0.5-0.7-0.7
Conditioned locomotion0.20.20.6-0.60.40.40.4-0.2-0.20.3-0.1-0.4-0.40.60.8
Patch foraging indifference point 0 sec1.21.92.71.61.61.61.6-1.1-1.11.2-1.61.51.50.90.5
Patch foraging indifference point AUC1.51.72.8-1.2-1.7-1.7-1.71.21.2-1.31.5-1.1-1.1-1.1-0.5
Delay disc. indifference point, 0s delay0.00.00.1-0.1-0.1-0.1-0.10.20.2-0.00.2-0.3-0.3-0.1-0.1
Delay disc. indifference point, 16s delay0.10.10.6-0.8-0.0-0.0-0.00.30.3-0.10.0-0.1-0.10.0-0.2
Delay disc. indifference point, 2s delay0.10.10.5-0.4-0.1-0.1-0.10.00.0-0.00.3-0.7-0.70.00.2
Delay disc. indifference point, 24s delay0.60.61.20.00.70.70.7-0.8-0.81.0-0.70.50.51.11.0
Delay disc. indifference point, 4s delay0.40.41.20.50.50.50.5-0.6-0.60.7-0.30.50.50.91.1
Delay disc. indifference point, 8s delay0.40.41.6-0.30.40.40.4-0.6-0.60.6-0.40.30.31.01.3
Indifference point function ln k0.50.71.2-0.8-0.6-0.6-0.61.11.1-1.00.6-0.7-0.7-1.0-0.8
Indifference point function log k0.50.71.2-0.8-0.6-0.6-0.61.11.1-1.00.6-0.7-0.7-1.0-0.8
Patch foraging total patch changes 0 sec1.22.03.41.91.61.61.6-1.2-1.21.2-1.61.51.50.80.5
Patch foraging total patch changes 12 sec0.10.10.60.80.10.10.10.10.10.0-0.30.40.4-0.3-0.4
Patch foraging total patch changes 18 sec2.12.74.62.11.61.61.6-1.6-1.61.5-1.61.81.81.21.1
Patch foraging total patch changes 24 sec0.60.72.11.40.80.80.8-1.0-1.01.0-0.90.70.70.5-0.4
Patch foraging total patch changes 6 sec1.01.54.12.01.21.21.2-1.3-1.31.3-1.11.21.20.80.2
Patch foraging time to switch 0 sec4.16.37.72.02.72.72.7-2.5-2.52.8-2.82.62.62.51.7
Patch foraging water rate 0 sec0.50.71.40.0-0.8-0.8-0.80.90.9-1.20.8-0.9-0.9-1.2-0.5
Patch foraging water rate 12 sec0.20.40.90.5-0.5-0.5-0.50.60.6-0.70.5-0.4-0.4-0.9-0.7
Patch foraging water rate 18 sec0.10.10.40.60.40.40.4-0.3-0.30.2-0.50.00.00.1-0.1
Patch foraging water rate 24 sec0.30.41.00.7-0.4-0.4-0.40.70.7-0.70.6-0.4-0.4-1.0-0.8
Patch foraging water rate 6 sec0.40.50.9-0.4-0.6-0.6-0.60.90.9-0.80.8-0.6-0.6-0.9-0.8
Seeking ratio, delayed vs. immediate footshock0.10.10.30.20.20.20.20.10.10.2-0.00.50.50.00.1
Distance traveled before self-admin0.20.20.70.8-0.0-0.0-0.0-0.1-0.1-0.1-0.00.80.80.40.8
Distance traveled after self-admin0.30.41.00.50.40.40.4-0.2-0.20.1-0.50.90.90.71.0
Extensor digitorum longus weight0.62.45.4-2.3-1.5-1.5-1.51.81.8-1.61.4-1.5-1.5-1.2-0.4
Bone: elastic displacement0.30.30.90.9-0.5-0.5-0.50.30.3-0.40.5-0.6-0.6-0.7-0.9
Bone: elastic work0.10.10.70.80.30.30.3-0.4-0.40.4-0.30.10.10.1-0.1
Bone: endosteal estimation0.71.58.7-1.10.60.60.6-0.6-0.60.6-0.50.90.91.93.0
Bone: endosteal perimeter0.30.64.1-0.90.10.10.1-0.1-0.10.1-0.00.60.61.12.0
Epididymis fat weight6.314.728.95.43.93.93.9-4.2-4.24.3-3.73.63.62.81.1
Delta time in closed arm before/after self-admin0.90.81.51.20.90.90.9-0.9-0.90.8-0.80.90.90.80.8
Delta time in open arm before/after self-admin0.10.10.2-0.2-0.1-0.1-0.10.20.2-0.00.1-0.4-0.4-0.3-0.3
Diff in mean of infusions in LGA sessions0.10.10.3-0.30.20.20.2-0.6-0.60.1-0.2-0.0-0.00.20.0
Delay discount exponential model param0.10.10.30.3-0.1-0.1-0.10.20.2-0.30.00.00.0-0.5-0.5
Extinction: sum of active levers before priming0.10.10.4-0.0-0.2-0.2-0.20.30.3-0.60.1-0.1-0.1-0.3-0.3
Active lever presses in extinction session 61.91.92.71.01.61.61.6-1.6-1.61.3-1.50.80.81.41.1
Bone: final force4.47.18.22.12.72.72.7-2.6-2.62.8-2.82.92.92.72.4
Bone: final moment3.35.35.72.02.42.42.4-2.2-2.22.4-2.42.42.42.32.1
Food consumed during 24 hour testing period1.82.14.1-0.11.51.51.5-1.3-1.31.4-1.51.41.41.92.0
Glucose4.06.07.2-2.2-2.7-2.7-2.72.72.7-2.62.7-2.5-2.5-2.0-1.0
Heart weight2.53.65.0-1.9-1.8-1.8-1.81.71.7-1.91.8-2.2-2.2-1.9-2.0
Delay discount hyperbolic model param0.00.00.20.3-0.0-0.0-0.00.10.1-0.2-0.10.20.2-0.4-0.5
Intermittent access intake day 1-15 change0.40.40.90.90.20.20.2-0.5-0.50.6-0.51.01.00.50.6
Intermittent access intake escalation0.40.41.00.70.20.20.2-0.5-0.50.6-0.51.01.00.71.0
Intermittent access intake escalation 21.11.01.5-1.1-1.2-1.2-1.21.11.1-1.10.9-0.8-0.8-1.0-0.4
Intermitt. access day 1 inactive lever presses0.60.71.4-0.2-0.6-0.6-0.61.21.2-1.10.9-0.2-0.2-1.0-0.9
Intermitt. access day 15 inactive lever presses0.20.30.70.20.50.50.5-0.1-0.10.2-0.30.90.90.50.6
Intermitt. access escalation Index0.30.20.50.0-0.6-0.6-0.60.50.5-0.50.5-0.1-0.1-0.6-0.7
Intermittent access day 1 total infusions0.50.61.4-0.7-0.5-0.5-0.50.90.9-0.80.4-1.2-1.2-0.7-0.6
Intermittent access day 15 total infusions0.00.00.20.4-0.2-0.2-0.20.10.1-0.1-0.2-0.0-0.0-0.1-0.0
Intermittent access terminal intake (last 3 days)0.00.10.10.2-0.3-0.3-0.30.20.2-0.2-0.0-0.3-0.2-0.10.0
Intermittent access total infusions0.10.20.4-0.2-0.2-0.2-0.20.50.5-0.4-0.1-0.6-0.6-0.3-0.2
Intermittent access day 1 locomotion0.10.10.3-0.0-0.1-0.1-0.10.30.3-0.20.2-0.2-0.20.20.5
Intermittent access day 15 total locomotion1.71.86.30.91.01.01.0-1.1-1.11.3-1.01.31.31.92.5
Intermittent access total locomotion0.80.94.10.40.70.70.7-0.6-0.60.8-0.70.60.61.42.0
Intermittent access standard deviation1.31.32.11.11.21.21.2-0.9-0.91.0-1.31.51.51.00.9
Left kidney weight0.51.46.20.41.01.01.0-0.6-0.60.7-1.01.31.31.42.5
Right kidney weight0.51.48.20.00.80.80.8-0.5-0.50.6-0.61.31.31.42.9
Cocaine induced anxiety0.20.30.5-0.4-0.5-0.5-0.50.70.7-0.70.60.00.0-0.5-0.3
Post-drug Anxiety0.00.10.1-0.2-0.3-0.3-0.30.10.1-0.10.30.10.10.10.4
Baseline Anxiety0.50.51.30.50.50.50.5-1.1-1.11.0-0.70.20.20.80.6
Tail length1.33.85.5-2.1-2.2-2.2-2.22.32.3-2.22.2-1.4-1.4-0.91.3
Length with tail0.41.36.9-1.4-0.9-0.9-0.91.11.1-0.80.7-0.3-0.30.52.6
Length without tail0.51.15.3-0.60.80.80.8-0.6-0.60.8-1.00.70.71.42.3
Times rat made contact with spout0.10.20.90.60.20.20.2-0.1-0.10.2-0.2-0.3-0.3-0.4-0.9
Lifetime Intake0.00.00.2-0.1-0.0-0.0-0.00.20.2-0.1-0.2-0.4-0.40.00.2
Liver weight, left0.81.38.9-0.20.40.40.4-0.5-0.50.5-0.21.11.11.63.0
Liver weight, right2.44.09.2-3.0-2.2-2.2-2.22.22.2-2.02.3-1.1-1.1-0.51.6
Locomotor activity0.10.20.9-0.0-0.2-0.2-0.20.90.9-0.50.30.20.2-0.60.2
Locomotor testing distance0.10.20.40.60.50.50.50.10.10.2-0.20.60.6-0.3-0.3
Locomotor testing rearing0.61.01.70.61.01.01.0-0.9-0.90.9-0.81.31.31.11.1
Locomotion in novel chamber0.40.61.5-0.1-0.5-0.5-0.50.80.8-0.90.4-0.8-0.8-1.0-1.2
Locomotion in novel chamber post-restriction2.22.73.21.61.61.61.6-1.8-1.81.7-1.51.61.61.81.4
Fecal boli incidents, locomotor time 10.40.50.8-0.20.80.80.8-0.7-0.70.5-0.80.30.30.90.9
Change in fecal boli incidents, locomotor task0.10.10.20.4-0.3-0.3-0.30.00.00.00.30.00.00.10.2
Time >=10cm from walls, locomotor time 13.73.74.51.91.91.91.9-1.9-1.92.0-1.82.12.11.91.8
Bouts of movement, locomotor time 10.30.40.8-0.1-0.9-0.9-0.90.70.7-0.70.6-0.3-0.3-0.20.1
Total resting periods, locomotor time 10.30.40.8-0.5-0.9-0.9-0.90.60.6-0.50.6-0.3-0.3-0.00.4
Rest time, locomotor task time 10.70.71.3-0.4-1.1-1.1-1.10.80.8-0.91.0-0.9-0.9-0.5-0.4
Distance moved, locomotor task time 11.31.41.80.91.41.41.4-1.3-1.31.2-1.31.21.20.80.7
Vertical activity count, locomotor time 15.15.37.11.22.72.72.7-2.3-2.32.2-2.52.22.22.02.2
Time >=10cm from walls, locomotor time 25.96.27.62.02.52.52.5-2.7-2.72.7-2.42.32.32.82.3
Bouts of movement, locomotor time 20.20.20.9-0.2-0.5-0.5-0.5-0.0-0.0-0.10.60.00.00.61.0
Total resting periods, locomotor time 20.60.61.4-0.5-1.1-1.1-1.10.60.6-0.71.2-0.6-0.6-0.00.4
Rest time, locomotor task time 20.80.91.6-0.0-1.2-1.2-1.21.11.1-1.21.1-0.7-0.7-0.8-0.4
Distance moved, locomotor task time 23.84.45.61.02.32.32.3-2.4-2.42.2-2.21.81.82.11.9
Vertical activity count, locomotor time 23.84.15.40.42.32.32.3-2.2-2.22.0-2.11.61.62.22.2
Light reinforcement 12.03.66.21.31.91.91.9-1.9-1.91.9-1.92.52.51.61.6
Light reinforcement 21.82.43.50.61.41.41.4-1.7-1.71.5-1.41.91.91.81.6
Bone: marrow area0.81.69.2-1.10.70.70.7-0.7-0.70.7-0.61.01.02.03.0
Bone: maximum diameter0.81.43.8-2.0-1.2-1.2-1.21.31.3-1.21.3-1.0-1.0-0.50.3
Bone: maximum force0.91.51.90.71.41.41.4-1.1-1.11.4-1.31.31.31.31.2
Bone: maximum moment0.50.81.10.61.01.01.0-0.7-0.71.0-0.90.80.90.91.0
Mean time between licks in bursts5.78.116.4-4.1-3.0-3.0-3.03.13.1-3.03.0-2.5-2.5-1.9-1.1
Mean num. licks in bursts0.81.02.31.51.01.01.0-1.3-1.31.0-1.00.60.60.70.2
Cd content in liver3.53.85.82.42.12.12.1-2.1-2.12.1-2.11.61.61.61.1
Co content in liver5.36.28.12.82.62.62.6-2.6-2.62.6-2.62.52.52.21.5
Cu content in liver0.40.42.70.8-0.1-0.1-0.10.00.0-0.10.1-0.6-0.6-0.9-1.7
Fe content in liver0.50.60.90.90.60.60.6-0.6-0.60.6-0.60.90.90.90.9
K content in liver3.93.84.9-2.2-2.0-2.0-2.02.22.2-2.02.0-1.9-1.9-1.7-1.3
Mg content in liver9.09.211.8-3.4-3.1-3.1-3.13.23.2-3.13.1-3.1-3.1-2.6-1.9
Mn content in liver4.55.111.9-3.4-2.4-2.4-2.42.32.3-2.42.4-2.0-2.0-1.2-0.2
Na content in liver0.20.20.30.4-0.5-0.5-0.50.30.3-0.50.5-0.2-0.2-0.4-0.2
Rb content in liver0.10.10.4-0.00.30.30.3-0.4-0.40.3-0.30.00.00.60.5
Se content in liver12.715.620.1-4.5-4.2-4.2-4.24.14.1-4.24.2-3.8-3.8-3.4-2.4
Sr content in liver0.50.50.60.70.80.80.8-0.8-0.80.8-0.80.30.30.80.5
Zn content in liver0.30.40.5-0.7-0.6-0.6-0.60.70.7-0.60.6-0.7-0.7-0.3-0.1
Bone: minimum diameter0.10.21.6-0.90.10.10.10.10.10.1-0.10.20.20.61.3
Time in familiar zone, hab. session 10.10.10.40.60.10.10.1-0.3-0.30.2-0.10.00.0-0.1-0.5
Time in novel zone, hab. session 10.00.00.1-0.1-0.2-0.2-0.20.00.0-0.20.3-0.0-0.00.00.2
Total zone transitions, hab. session 12.02.87.4-0.4-1.5-1.5-1.51.61.6-1.41.5-1.5-1.5-2.4-2.7
Total locomotion distance, hab. session 12.53.56.3-1.4-1.8-1.8-1.81.81.8-1.71.9-1.7-1.7-2.3-2.5
Locomotion velocity, hab. session 12.63.76.3-1.6-1.8-1.8-1.82.12.1-1.71.9-1.7-1.7-2.3-2.5
Time in familiar zone, hab. session 20.20.20.7-0.9-0.3-0.3-0.30.50.5-0.30.3-0.1-0.1-0.3-0.3
Time in novel zone, hab. session 20.60.61.41.20.80.80.8-1.0-1.00.8-0.80.40.40.70.7
Total zone transitions, hab. session 20.60.71.7-0.1-0.9-0.9-0.90.80.8-0.80.9-0.4-0.4-1.3-1.3
Total locomotion distance, hab. session 21.92.55.0-1.0-1.5-1.5-1.51.71.7-1.51.5-1.1-1.1-2.1-2.2
Locomotion velocity, hab. session 22.83.76.3-1.3-1.9-1.9-1.92.12.1-1.91.9-1.5-1.5-2.4-2.5
Novel to familiar place preference ratio0.00.00.20.40.10.10.1-0.2-0.20.2-0.30.10.1-0.1-0.3
Novelty place preference0.00.00.10.3-0.0-0.0-0.0-0.0-0.00.1-0.10.00.0-0.2-0.3
Time in novel zone, NPP test0.00.00.10.3-0.0-0.0-0.0-0.2-0.20.1-0.10.00.0-0.0-0.1
Total zone transitions, NPP test2.02.84.0-1.0-1.8-1.8-1.81.51.5-1.61.8-1.6-1.7-1.9-2.0
Total locomotion distance, NPP test0.50.71.7-0.3-0.8-0.8-0.80.60.6-0.60.8-0.9-0.9-1.0-1.3
Locomotion velocity, NPP test0.71.02.7-0.3-0.9-0.9-0.90.80.8-0.80.9-1.0-1.0-1.3-1.6
Intraocular pressure0.10.20.40.00.30.30.3-0.2-0.20.2-0.40.60.60.50.6
Delta distance traveled before/after self-admin0.10.10.2-0.20.40.40.4-0.1-0.10.3-0.4-0.0-0.00.20.1
Delta ambulatory time before/after self-admin0.00.00.1-0.30.30.30.30.00.00.1-0.3-0.1-0.10.20.1
Parametrial fat weight1.63.05.12.21.51.51.5-1.6-1.61.7-1.62.12.11.61.7
Pavlov. Cond. lever latency6.07.68.82.33.03.03.0-2.9-2.92.8-2.82.72.72.72.3
Pavlov. Cond. magazine entry latency5.06.57.8-2.7-2.8-2.8-2.82.52.5-2.52.7-2.6-2.6-2.1-1.6
Pavlov. Cond. change in total contacts1.11.21.7-0.8-1.3-1.3-1.31.11.1-1.11.2-1.0-1.0-1.0-0.8
Pavlov. Cond. index score6.07.58.9-2.5-3.0-3.0-3.02.82.8-2.82.9-2.8-2.8-2.5-2.0
Pavlov. Cond. latency score5.77.28.5-2.6-2.9-2.9-2.92.82.8-2.72.8-2.7-2.7-2.4-1.9
Pavlov. Cond. lever contacts4.55.36.0-1.8-2.4-2.4-2.42.42.4-2.22.4-2.4-2.4-2.3-1.9
Pavlov. Cond. magazine entry number4.55.66.82.32.62.62.6-2.3-2.32.4-2.52.42.42.11.7
Pavlov. Cond. intertrial magazine entries1.72.13.41.11.71.71.7-1.7-1.71.8-1.41.11.11.30.7
Pavlov. Cond. lever-magazine prob. diff.6.07.48.6-2.5-2.9-2.9-2.92.82.8-2.72.8-2.7-2.7-2.5-2.0
Pavlov. Cond. response bias6.88.39.5-2.7-3.1-3.1-3.12.92.9-2.93.0-3.0-3.0-2.6-2.1
Pavlov. Cond. lever latency1.11.52.41.01.11.11.1-1.1-1.11.2-1.11.61.61.11.3
Pavlov. Cond. magazine entry latency0.20.21.1-0.10.10.10.1-0.4-0.40.2-0.10.00.00.81.0
Pavlov. Cond. change in total contacts0.20.30.8-0.7-0.6-0.6-0.60.30.3-0.50.5-0.9-0.9-0.4-0.5
Pavlov. Cond. index score0.30.30.8-0.6-0.6-0.6-0.60.40.4-0.50.6-0.9-0.9-0.2-0.2
Pavlov. Cond. latency score0.20.20.5-0.5-0.5-0.5-0.50.30.3-0.50.5-0.7-0.7-0.1-0.1
Pavlov. Cond. lever contacts0.20.30.9-0.3-0.4-0.4-0.40.30.3-0.40.4-0.9-0.9-0.6-1.0
Pavlov. Cond. magazine entry number0.20.30.8-0.2-0.4-0.4-0.40.70.7-0.50.5-0.3-0.3-0.9-0.8
Pavlov. Cond. intertrial magazine entries1.82.38.0-2.8-1.6-1.6-1.61.41.4-1.51.6-1.1-1.1-1.0-0.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.4-0.4-0.4-0.40.10.1-0.30.4-0.6-0.60.00.0
Pavlov. Cond. response bias0.40.51.2-0.8-0.7-0.7-0.70.40.4-0.60.8-1.1-1.1-0.5-0.6
Time in closed arm before self-admin0.10.10.2-0.50.40.40.40.00.00.1-0.1-0.2-0.20.1-0.1
Time in closed arm after self-admin0.20.20.50.50.70.70.7-0.4-0.40.4-0.40.20.20.3-0.0
Time in open arm before self-admin1.01.11.4-0.5-1.2-1.2-1.20.90.9-1.11.1-1.1-1.1-1.1-0.8
Time in open arm after self-admin1.31.42.0-1.1-1.3-1.3-1.31.01.0-1.01.1-1.4-1.4-1.1-0.7
Bone: periosteal estimation0.30.63.2-0.70.50.50.5-0.3-0.30.4-0.40.70.71.11.8
Bone: periosteal perimeter0.10.21.20.00.20.20.2-0.2-0.20.2-0.30.50.50.61.1
Bone: post-yield work0.10.21.7-1.30.10.10.10.20.20.0-0.0-0.1-0.10.30.6
Progressive ratio test 1 active lever presses0.10.10.30.3-0.1-0.1-0.1-0.1-0.10.1-0.0-0.5-0.50.10.1
Progressive ratio test 1 breakpoint0.10.10.20.4-0.0-0.0-0.0-0.1-0.10.1-0.0-0.5-0.50.10.1
Progressive ratio test 1 inactive lever presses1.01.02.41.61.01.01.0-1.0-1.00.9-1.01.11.10.80.4
Progressive ratio test 2 active lever presses0.10.10.80.90.00.00.0-0.3-0.30.3-0.20.10.10.20.1
Progressive ratio test 2 breakpoint0.10.10.80.9-0.1-0.1-0.1-0.1-0.10.2-0.10.00.0-0.0-0.1
Progressive ratio test 2 inactive lever presses0.40.50.8-0.5-0.6-0.6-0.60.60.6-0.60.7-0.9-0.9-0.7-0.5
Incentive Sensitization - Responses0.50.51.10.5-0.7-0.7-0.70.80.8-0.70.5-0.3-0.3-1.0-1.0
Incentive Sensitization - Breakpoint0.30.30.70.7-0.6-0.6-0.60.60.6-0.50.4-0.0-0.0-0.8-0.8
Sum of active levers in priming session hrs 5-60.40.40.8-0.9-0.3-0.3-0.30.50.5-0.70.3-0.9-0.9-0.8-0.7
Progressive ratio4.24.96.22.22.12.12.1-2.1-2.12.0-2.02.52.52.42.1
Food seeking constrained by brief footshock0.50.61.00.81.01.01.0-0.9-0.90.8-1.00.40.40.70.3
Seeking ratio, punishment vs. effort2.02.53.5-1.4-1.4-1.4-1.41.51.5-1.41.3-1.8-1.8-1.8-1.9
Retroperitoneal fat weight0.72.43.82.01.31.31.3-1.8-1.81.7-1.21.51.51.81.4
Reaction time number correct2.02.84.22.01.51.51.5-1.9-1.91.8-1.61.91.91.31.3
Reaction time mean minus median1.52.03.7-1.9-1.6-1.6-1.61.61.6-1.41.3-1.2-1.2-0.60.0
Reaction time mean minus median AUC1.01.33.4-1.8-1.2-1.2-1.21.21.2-1.10.9-1.2-1.2-0.20.0
Reaction time num false alarms1.11.62.9-1.7-1.3-1.3-1.31.51.5-1.61.2-0.8-0.8-1.0-0.2
Reaction time num false alarms AUC1.92.64.0-2.0-1.7-1.7-1.71.91.9-1.91.6-1.2-1.2-1.5-0.7
Reaction time trials correct on left2.02.84.22.01.51.51.5-1.9-1.91.8-1.61.91.91.31.3
Reaction time trials on left2.02.84.02.01.51.51.5-1.9-1.91.8-1.71.81.81.31.3
Reaction time mean0.20.32.3-1.5-0.3-0.3-0.30.50.5-0.40.3-0.6-0.60.20.1
Reaction time mean AUC0.10.21.5-1.2-0.1-0.1-0.10.10.1-0.00.1-0.3-0.30.60.3
Median of all reaction times0.10.10.9-0.90.20.20.2-0.1-0.10.2-0.1-0.0-0.00.60.2
Reaction time omissions0.20.31.0-1.0-0.6-0.6-0.60.60.6-0.70.6-0.4-0.4-0.1-0.0
Reaction time false alarm rate4.46.18.4-2.9-2.4-2.4-2.42.82.8-2.82.5-2.2-2.2-2.2-1.4
Reaction time premature initiation rate0.00.10.50.10.20.20.20.00.0-0.1-0.30.10.1-0.1-0.7
Reaction time premature initiations1.01.42.01.31.31.31.3-1.2-1.21.1-1.41.31.30.80.3
Std. dev. reaction times1.42.05.1-2.3-1.5-1.5-1.51.61.6-1.41.3-1.4-1.4-0.5-0.0
Reaction time trials completed2.02.84.02.01.51.51.5-1.9-1.91.8-1.71.81.81.31.3
Reaction time trials AUC2.13.04.02.01.61.61.6-1.9-1.91.8-1.71.91.91.41.3
Run reversals in cocaine runway, females0.50.51.00.11.01.01.0-0.7-0.70.7-1.00.30.30.60.5
Run reversals in cocaine runway, males1.81.83.2-1.8-1.4-1.4-1.41.61.6-1.41.4-1.1-1.1-0.8-0.1
Latency to leave start box in cocaine runway0.30.31.00.0-0.6-0.6-0.60.40.4-0.30.4-0.5-0.5-0.6-1.0
Latency to leave start box in cocaine runway, F0.30.30.90.0-0.6-0.6-0.60.50.5-0.40.4-0.5-0.5-0.7-0.9
Latency to leave start box in cocaine runway, M0.10.10.40.5-0.3-0.3-0.30.20.2-0.10.3-0.1-0.1-0.3-0.7
Std. dev. time between licks in bursts5.36.48.3-2.9-2.8-2.8-2.82.82.8-2.82.8-2.1-2.1-1.9-1.1
Total sessions with >9 infusions0.10.10.3-0.2-0.2-0.2-0.20.10.1-0.10.1-0.6-0.60.10.4
Short access day 1 total inactive lever presses0.40.41.0-0.8-0.2-0.2-0.20.70.7-0.60.7-1.0-1.0-0.5-0.1
Short access day 10 total inactive lever presses0.30.40.70.4-0.5-0.5-0.50.80.8-0.80.80.50.5-0.6-0.5
Short access day 1 total infusions1.61.72.9-1.3-1.0-1.0-1.01.51.5-1.40.9-1.7-1.7-1.3-0.9
Short access day 10 total infusions0.00.00.10.00.10.10.10.10.1-0.1-0.3-0.00.00.10.4
Short access total infusions0.10.10.4-0.3-0.2-0.2-0.20.30.3-0.20.0-0.6-0.6-0.10.1
Short access day 1 locomotion0.60.71.20.0-0.9-0.9-0.91.11.1-0.90.8-0.5-0.5-0.7-0.7
Short access day 10 total locomotion1.11.22.1-0.3-1.1-1.1-1.11.51.5-1.31.3-0.9-0.9-0.9-0.3
Short access total locomotion0.10.10.4-0.0-0.1-0.1-0.10.20.2-0.10.3-0.1-0.10.30.7
One hour access (0.3 mA shock)1.11.31.8-0.5-1.2-1.2-1.21.31.3-1.41.0-1.0-1.0-1.2-0.9
Compulsive drug intake0.90.91.6-1.3-0.7-0.7-0.71.01.0-1.20.7-0.9-0.9-1.0-0.9
One hour access (shock baseline)0.10.10.2-0.1-0.4-0.4-0.40.10.1-0.00.2-0.4-0.40.10.4
Social response proportion0.10.20.6-0.8-0.3-0.3-0.30.40.4-0.50.2-0.3-0.3-0.20.3
Social responses0.10.10.2-0.3-0.4-0.4-0.40.50.5-0.40.3-0.1-0.1-0.4-0.2
Social time2.02.76.0-2.5-1.7-1.7-1.72.02.0-1.91.6-1.0-1.0-1.3-0.5
Soleus weight2.26.413.1-3.6-2.7-2.7-2.72.92.9-2.72.6-2.1-2.1-1.40.3
Bone: stiffness1.01.51.90.21.31.31.3-1.1-1.11.3-1.21.41.41.31.2
Tibialis anterior weight0.10.41.0-0.8-0.4-0.4-0.40.70.7-0.60.4-0.7-0.7-0.9-1.0
Time to tail flick, vehicle, before self-admin0.30.31.40.50.00.00.0-0.3-0.30.0-0.01.21.20.40.6
Time to tail flick, vehicle, after self-admin0.10.10.70.80.30.30.3-0.0-0.00.3-0.10.20.20.00.2
Time to tail flick, test, before self-admin0.20.21.01.0-0.2-0.2-0.20.20.2-0.20.30.30.3-0.4-0.7
Time to tail flick, test, after self-admin0.50.51.40.3-0.9-0.9-0.90.60.6-0.61.2-0.5-0.5-0.4-0.2
Delta time to tail flick, vehicle, before/after SA0.20.20.40.40.40.40.4-0.2-0.20.5-0.3-0.6-0.6-0.1-0.3
Delta time to tail flick, test, before/after SA0.50.51.20.20.50.50.5-0.7-0.70.8-0.40.60.61.01.1
Tibia length0.41.26.3-0.90.50.50.5-0.5-0.50.6-0.41.21.21.52.5
Ambulatory time before self-admin0.10.10.50.7-0.1-0.1-0.1-0.1-0.1-0.20.00.50.50.20.4
Ambulatory time after self-admin0.10.10.30.20.10.10.10.10.1-0.2-0.20.50.50.30.5
Bone: tissue strength0.90.82.71.71.01.01.0-0.8-0.80.9-1.00.60.60.70.4
Total heroin consumption0.00.00.3-0.5-0.0-0.0-0.0-0.0-0.0-0.4-0.10.00.0-0.10.2
Bone: trabecular number0.20.30.9-0.9-0.2-0.2-0.20.40.4-0.20.2-0.5-0.5-0.6-0.9
Bone: trabecular spacing1.01.32.31.21.01.01.0-1.0-1.00.9-1.01.21.21.31.5
Bone: trabecular thickness0.10.10.4-0.60.30.30.3-0.2-0.20.3-0.20.20.20.40.4
Bone: trabecular tissue density0.50.71.0-0.6-0.9-0.9-0.91.01.0-0.90.9-0.8-0.8-0.6-0.3
Water consumed over 24 hours0.10.10.20.3-0.1-0.1-0.10.10.1-0.00.1-0.5-0.5-0.3-0.3
Number of responses in last shaping day3.73.86.4-1.8-1.8-1.8-1.81.81.8-1.81.9-2.5-2.5-2.0-1.8