Hub : Genes

Scn4a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Scn4a 0.42 0.11 0.0e+00 0.42 0.41 0.42 0.43 3.8e-53 2.9e-51 1.1e-52 1.4e-54
2 Brain gene expression Scn4a 0.42 0.1 0.0e+00 0.39 0.37 0.39 0.4 7.6e-38 3.9e-36 1.4e-38 1.3e-39
3 LHb gene expression Scn4a 0.58 0.14 2.7e-08 0.22 0.21 0.19 0.24 5.7e-06 8.5e-06 2.5e-05 2.2e-06
4 Adipose gene expression Scn4a 0.33 0.09 0.0e+00 0.31 0.31 0.32 0.33 5.6e-35 9.7e-35 5.1e-36 2.8e-37
5 Adipose mRNA stability Scn4a 0.04 0.02 1.1e-05 0.03 0.02 0.02 0.02 5.1e-04 1.1e-03 2.0e-03 3.1e-03
6 pVTA gene expression Scn4a 0.29 0.09 4.3e-15 0.26 0.33 0.3 0.18 1.4e-11 8.9e-15 1.5e-13 2.1e-08
7 PL gene expression Scn4a 0.11 0.05 1.1e-13 0.13 0.12 0.12 0.13 1.0e-13 4.7e-13 1.7e-13 3.8e-14
8 RMTg gene expression Scn4a 0.17 0.08 1.4e-04 0.12 0.11 0.11 0.12 4.1e-04 9.0e-04 9.2e-04 4.5e-04
9 BLA gene expression Scn4a 0.28 0.09 0.0e+00 0.35 0.37 0.36 0.38 2.0e-19 5.6e-21 1.8e-20 1.3e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.33.89.71.71.92.63.11.91.91.7-0.50.8
Area under the delay curve0.10.10.10.10.10.30.40.2-0.20.30.20.1
BMI with tail0.10.41.5-0.1-0.2-0.5-1.2-0.3-1.0-0.20.40.0
BMI without tail0.71.52.61.51.51.30.80.90.61.6-0.91.5
Body weight1.56.39.33.03.02.31.73.11.92.4-2.22.6
Weight adjusted by age0.91.11.6-1.2-1.1-1.0-1.3-1.3-1.2-0.80.4-0.7
Bone surface7.613.420.83.74.04.44.63.93.83.1-2.42.5
Bone volume6.210.518.03.23.34.04.23.43.32.9-2.02.2
Breakpoint value in progressive ratio session1.01.12.10.90.81.10.90.71.31.0-1.41.1
Number of licking bursts0.00.00.0-0.0-0.10.0-0.0-0.0-0.0-0.20.1-0.1
Context. condit. distance diff. score0.30.41.5-0.5-0.6-0.8-1.2-0.4-0.5-0.60.1-0.1
Locomotion velocity, session 11.71.82.91.41.71.51.71.71.31.0-0.60.7
Locomotion distance, session 10.20.20.80.50.90.30.50.60.20.20.1-0.1
Locomotion velocity, session 20.91.12.41.00.90.81.11.01.60.7-1.20.8
Locomotion distance, session 20.10.10.30.50.6-0.2-0.00.60.4-0.1-0.30.0
Locomotion velocity, session 30.30.30.8-0.6-0.4-0.2-0.2-0.3-0.4-0.70.8-0.9
Locomotion distance, session 30.10.10.20.10.20.40.30.30.3-0.20.1-0.2
Stereotopy head waving bouts, day 30.30.31.1-0.6-0.4-0.20.3-0.4-0.5-0.21.1-0.8
Stereotopy head waving duration, day 30.30.40.7-0.7-0.6-0.6-0.3-0.6-0.7-0.30.9-0.7
Locomotion velocity, session 70.30.30.6-0.5-0.4-0.4-0.4-0.3-0.4-0.80.7-0.7
Locomotion distance, session 70.00.00.1-0.0-0.3-0.2-0.3-0.3-0.2-0.1-0.10.1
Stereotopy head waving bouts, day 70.20.20.7-0.6-0.5-0.30.0-0.3-0.2-0.50.7-0.8
Stereotopy head waving duration, day 71.21.52.2-1.4-1.4-1.3-0.9-0.9-0.8-1.41.3-1.5
Locomotion velocity, session 80.50.61.60.90.70.2-0.21.20.70.3-0.90.9
Locomotion distance, session 80.10.10.40.1-0.1-0.5-0.60.30.1-0.1-0.40.3
Degree of sensitization distance0.20.20.50.50.2-0.3-0.40.0-0.10.4-0.60.7
Degree of sensitization stereotypy0.60.71.2-0.9-0.9-0.9-0.7-0.5-0.4-1.10.8-1.1
Conditioned locomotion0.40.51.10.60.30.50.40.40.61.0-1.01.1
Cocaine response after cond. corrected0.40.51.0-0.6-0.4-0.2-0.6-0.4-0.8-1.00.9-0.9
Cocaine response after cond. not corrected0.50.61.7-0.6-0.3-0.0-0.3-0.2-0.5-1.31.0-1.2
Cocaine response before conditioning0.10.10.3-0.2-0.20.30.50.20.5-0.30.2-0.5
Saline control response1.31.73.61.10.90.90.60.91.41.5-1.91.9
Bone: connectivity density3.25.010.42.22.32.93.22.22.31.9-1.11.2
Bone: cortical apparent density4.76.28.4-2.8-2.3-2.3-1.9-2.7-2.6-2.12.9-2.6
Bone: cortical area2.13.26.61.51.92.52.61.81.61.6-0.60.9
Bone: cortical porosity10.511.517.33.33.64.23.83.63.92.5-2.82.6
Bone: cortical porosity6.06.510.72.52.83.32.92.82.81.7-1.91.7
Bone: cortical thickness3.45.613.1-2.6-1.9-1.1-0.7-2.0-2.3-2.23.6-3.3
Bone: cortical thickness2.83.36.2-2.0-1.7-1.0-0.7-1.8-1.4-2.02.5-2.5
Bone: cortical tissue density4.66.07.9-2.7-2.3-2.3-1.9-2.6-2.6-2.02.8-2.6
Condit. Reinf. active minus inactive responses3.43.84.91.91.82.01.91.82.21.9-2.11.9
Condit. Reinf. active-inactive response ratio1.51.62.41.21.01.31.31.21.51.3-1.41.2
Condit. Reinf. active responses4.04.95.82.22.12.12.12.02.42.3-2.42.3
Condit. Reinf. inactive responses1.21.42.01.21.41.11.21.11.01.2-1.01.2
Incentive salience index mean3.64.35.92.02.22.12.32.12.41.8-1.91.8
Condit. Reinf. lever presses0.71.01.60.91.20.91.21.11.30.7-0.80.7
Condit. Reinf. active minus inactive responses7.59.311.53.13.23.33.43.23.42.5-2.72.4
Condit. Reinf. active-inactive response ratio5.25.57.82.32.42.72.82.52.71.9-2.01.7
Condit. Reinf. active responses7.610.512.73.23.33.33.33.13.63.0-3.33.0
Condit. Reinf. inactive responses1.92.43.51.41.41.31.31.11.61.8-1.91.9
Condit. Reinf. lever presses2.33.14.51.71.91.91.71.72.11.3-1.81.6
Condit. Reinf. lever reinforcers received6.49.111.02.93.13.23.22.83.32.8-3.02.8
Conditioned reinforcement - actives0.70.71.11.01.00.60.50.80.60.9-0.90.9
Conditioned reinforcement - inactives1.21.41.91.41.21.11.11.41.11.1-1.01.2
Conditioned locomotion3.03.64.52.12.01.91.81.91.82.0-1.81.8
Patch foraging indifference point 0 sec4.57.29.52.92.32.52.72.62.63.1-2.62.8
Patch foraging indifference point AUC0.91.01.71.01.10.60.51.01.01.2-1.21.3
Delay disc. indifference point, 0s delay0.70.81.2-1.0-0.9-0.7-0.6-1.1-1.0-0.70.7-0.9
Delay disc. indifference point, 16s delay0.20.20.60.30.30.80.60.10.10.60.20.5
Delay disc. indifference point, 2s delay0.50.51.10.70.70.91.10.90.40.8-0.30.5
Delay disc. indifference point, 24s delay1.31.31.91.31.21.21.11.30.71.4-0.71.2
Delay disc. indifference point, 4s delay0.50.50.8-0.9-0.8-0.4-0.4-0.7-0.7-0.90.9-0.9
Delay disc. indifference point, 8s delay0.10.20.5-0.4-0.3-0.10.2-0.2-0.6-0.10.7-0.5
Indifference point function ln k0.30.41.0-0.5-0.40.30.6-0.5-0.4-0.30.9-1.0
Indifference point function log k0.30.41.0-0.5-0.40.30.6-0.5-0.4-0.30.9-1.0
Patch foraging total patch changes 0 sec4.87.79.53.02.52.72.72.72.63.1-2.72.9
Patch foraging total patch changes 12 sec5.46.910.32.92.21.81.92.62.63.0-3.23.1
Patch foraging total patch changes 18 sec2.83.65.22.11.81.71.41.72.01.9-2.32.2
Patch foraging total patch changes 24 sec4.25.15.92.42.22.22.32.32.32.4-2.12.2
Patch foraging total patch changes 6 sec2.84.15.82.11.81.92.12.02.02.4-2.02.0
Patch foraging time to switch 0 sec0.10.10.3-0.3-0.6-0.3-0.3-0.4-0.2-0.60.0-0.3
Patch foraging water rate 0 sec1.52.33.01.71.71.61.61.71.31.7-1.01.3
Patch foraging water rate 12 sec1.01.53.8-1.1-1.0-0.5-0.5-0.9-1.3-1.22.0-1.7
Patch foraging water rate 18 sec0.20.31.10.00.20.40.80.50.1-0.11.0-0.7
Patch foraging water rate 24 sec0.10.10.30.10.1-0.0-0.10.4-0.2-0.40.5-0.5
Patch foraging water rate 6 sec0.20.31.0-0.10.10.71.00.1-0.20.01.0-0.8
Seeking ratio, delayed vs. immediate footshock0.10.10.20.10.2-0.2-0.40.2-0.00.1-0.20.4
Distance traveled before self-admin0.40.40.9-0.8-0.5-0.2-0.5-0.7-0.6-0.80.6-1.0
Distance traveled after self-admin0.10.10.4-0.3-0.3-0.2-0.6-0.4-0.1-0.5-0.1-0.2
Extensor digitorum longus weight2.18.315.6-2.8-3.0-3.4-4.0-3.3-3.5-1.81.8-1.2
Bone: elastic displacement1.41.63.6-1.3-0.8-0.8-0.8-0.7-1.1-1.61.9-1.9
Bone: elastic work0.30.40.90.21.00.70.90.70.3-0.10.8-0.6
Bone: endosteal estimation16.836.741.66.56.26.05.66.06.45.5-6.36.1
Bone: endosteal perimeter18.137.542.86.56.26.25.66.36.25.8-6.26.1
Epididymis fat weight0.61.42.41.31.21.21.01.10.71.5-0.71.4
Delta time in closed arm before/after self-admin0.10.10.60.40.50.10.20.80.4-0.3-0.0-0.2
Delta time in open arm before/after self-admin0.80.82.0-1.0-1.0-0.8-0.9-1.4-1.0-0.20.5-0.3
Diff in mean of infusions in LGA sessions1.01.11.4-1.1-1.0-1.1-1.2-1.2-1.1-1.00.8-0.9
Delay discount exponential model param0.20.20.3-0.4-0.4-0.5-0.6-0.5-0.1-0.50.1-0.4
Extinction: sum of active levers before priming0.20.20.70.30.20.40.0-0.20.20.6-0.80.7
Active lever presses in extinction session 62.62.53.41.51.51.81.61.11.61.7-1.71.6
Bone: final force1.01.73.91.11.61.72.01.41.20.9-0.20.3
Bone: final moment1.21.94.51.21.81.92.11.51.31.0-0.20.3
Food consumed during 24 hour testing period2.63.14.32.02.11.51.12.11.41.8-1.81.9
Glucose1.31.92.8-1.4-1.5-1.1-1.6-1.3-1.4-1.71.1-1.2
Heart weight0.10.10.4-0.2-0.3-0.1-0.5-0.3-0.7-0.30.4-0.3
Delay discount hyperbolic model param0.10.10.3-0.3-0.2-0.4-0.5-0.40.0-0.40.0-0.3
Intermittent access intake day 1-15 change0.20.20.50.50.50.30.00.50.50.3-0.70.7
Intermittent access intake escalation0.00.00.10.20.2-0.1-0.20.20.1-0.0-0.30.3
Intermittent access intake escalation 20.60.60.90.90.80.60.50.80.80.6-0.90.9
Intermitt. access day 1 inactive lever presses6.06.48.02.52.42.72.72.52.82.3-2.52.3
Intermitt. access day 15 inactive lever presses3.23.55.61.61.72.42.31.52.02.0-1.51.6
Intermitt. access escalation Index3.73.34.1-1.9-1.9-2.0-2.0-1.4-1.8-2.01.6-1.7
Intermittent access day 1 total infusions0.70.81.20.91.01.00.90.90.51.1-0.60.6
Intermittent access day 15 total infusions0.40.50.80.80.90.50.30.80.30.8-0.70.7
Intermittent access terminal intake (last 3 days)2.42.63.31.81.81.51.41.61.41.8-1.61.7
Intermittent access total infusions3.03.34.52.02.11.71.62.01.61.9-1.71.7
Intermittent access day 1 locomotion4.24.55.82.32.42.22.12.21.82.2-1.81.8
Intermittent access day 15 total locomotion6.06.58.83.02.92.32.13.02.42.4-2.42.4
Intermittent access total locomotion9.210.513.33.63.73.13.13.53.03.2-2.92.9
Intermittent access standard deviation1.81.92.61.61.61.31.41.31.31.3-1.21.3
Left kidney weight0.61.63.3-1.1-0.8-0.8-0.9-0.7-1.3-1.51.8-1.8
Right kidney weight0.20.61.8-0.30.1-0.3-0.20.2-0.6-1.01.3-1.3
Cocaine induced anxiety0.20.20.6-0.4-0.30.30.4-0.4-0.3-0.20.8-0.6
Post-drug Anxiety0.30.41.0-0.6-0.40.20.2-0.7-0.6-0.41.0-0.9
Baseline Anxiety0.91.01.4-1.0-0.8-0.9-0.9-1.0-1.1-1.01.1-1.2
Tail length2.57.58.83.03.02.82.82.82.52.7-2.42.6
Length with tail2.38.412.63.13.32.92.83.52.82.5-2.42.5
Length without tail0.51.02.81.11.20.91.01.71.10.5-0.70.5
Times rat made contact with spout1.01.22.51.21.60.90.71.31.10.6-0.91.0
Lifetime Intake3.54.04.82.22.22.02.02.01.82.1-1.81.8
Liver weight, left0.81.32.61.11.21.11.11.61.30.7-0.90.9
Liver weight, right0.50.82.5-0.7-0.5-0.4-0.0-0.3-0.9-0.81.6-1.4
Locomotor activity0.61.02.41.21.20.70.61.61.20.7-0.70.6
Locomotor testing distance1.72.83.61.81.91.51.11.91.91.4-1.71.6
Locomotor testing rearing1.62.54.51.81.51.10.71.61.91.2-2.11.7
Locomotion in novel chamber0.10.10.60.30.3-0.2-0.30.80.0-0.60.1-0.1
Locomotion in novel chamber post-restriction1.72.12.81.51.31.51.71.21.21.7-1.41.5
Fecal boli incidents, locomotor time 10.10.10.2-0.4-0.4-0.1-0.4-0.5-0.40.1-0.10.2
Change in fecal boli incidents, locomotor task0.30.30.6-0.5-0.3-0.4-0.6-0.5-0.8-0.60.7-0.5
Time >=10cm from walls, locomotor time 12.92.94.4-1.6-1.8-1.7-1.9-1.3-1.5-2.11.5-1.7
Bouts of movement, locomotor time 10.30.40.7-0.7-0.8-0.5-0.3-0.7-0.7-0.30.8-0.5
Total resting periods, locomotor time 10.40.50.8-0.7-0.8-0.6-0.3-0.8-0.8-0.40.9-0.5
Rest time, locomotor task time 10.20.20.6-0.7-0.4-0.00.1-0.8-0.3-0.20.6-0.4
Distance moved, locomotor task time 10.80.91.71.31.10.50.61.30.80.8-0.80.9
Vertical activity count, locomotor time 10.50.51.11.00.90.60.71.10.70.4-0.40.4
Time >=10cm from walls, locomotor time 20.10.10.3-0.2-0.30.1-0.00.10.1-0.50.1-0.4
Bouts of movement, locomotor time 20.50.51.7-0.9-1.1-0.4-0.5-1.3-0.7-0.20.4-0.2
Total resting periods, locomotor time 20.91.02.4-1.2-1.4-0.7-0.7-1.5-0.9-0.50.7-0.5
Rest time, locomotor task time 24.95.79.2-2.7-2.7-2.0-2.0-3.0-2.5-1.92.2-2.0
Distance moved, locomotor task time 21.21.42.51.51.40.81.11.61.40.7-1.00.7
Vertical activity count, locomotor time 24.34.76.52.42.32.12.32.32.61.9-1.91.7
Light reinforcement 10.20.41.80.20.20.51.0-0.00.21.4-0.30.4
Light reinforcement 20.60.82.40.40.61.01.60.30.61.5-0.30.5
Bone: marrow area16.535.740.76.46.15.95.55.96.35.4-6.26.0
Bone: maximum diameter5.810.715.33.23.33.93.93.33.33.1-2.62.7
Bone: maximum force1.93.25.51.82.12.32.31.91.51.6-0.81.0
Bone: maximum moment2.13.56.31.92.32.42.52.01.61.7-0.81.0
Mean time between licks in bursts0.00.10.10.00.4-0.1-0.3-0.0-0.40.3-0.10.3
Mean num. licks in bursts0.30.40.90.60.90.40.40.50.40.7-0.60.7
Cd content in liver3.84.27.2-2.0-1.9-2.7-2.6-2.0-2.1-1.91.5-1.5
Co content in liver0.60.72.1-0.8-0.8-1.4-1.4-0.5-0.5-0.60.2-0.2
Cu content in liver0.30.40.80.30.30.70.90.30.60.9-0.50.6
Fe content in liver0.20.20.7-0.6-0.6-0.5-0.3-0.8-0.1-0.4-0.1-0.1
K content in liver1.01.01.41.00.60.91.21.21.11.1-0.90.9
Mg content in liver0.10.10.3-0.0-0.4-0.00.40.10.30.6-0.20.4
Mn content in liver0.20.20.90.30.10.31.00.40.50.30.2-0.2
Na content in liver0.50.51.00.40.00.80.80.51.00.8-0.90.8
Rb content in liver2.83.44.6-2.1-2.1-2.1-1.7-1.8-1.6-1.81.6-1.7
Se content in liver1.61.92.8-1.6-1.7-1.7-1.5-1.1-1.4-1.11.2-1.1
Sr content in liver0.40.40.80.60.90.90.70.80.50.30.00.1
Zn content in liver0.10.10.2-0.10.20.30.40.50.10.10.4-0.4
Bone: minimum diameter14.427.030.45.55.45.55.15.45.15.0-4.84.9
Time in familiar zone, hab. session 10.70.61.70.90.50.2-0.10.60.40.8-1.21.3
Time in novel zone, hab. session 11.21.12.3-1.3-1.0-0.4-0.2-1.1-0.8-1.11.4-1.5
Total zone transitions, hab. session 10.20.30.90.80.90.1-0.11.00.20.0-0.20.2
Total locomotion distance, hab. session 11.21.73.71.51.91.31.51.71.20.8-0.40.4
Locomotion velocity, hab. session 11.62.34.81.82.21.41.62.11.41.1-0.70.8
Time in familiar zone, hab. session 21.41.43.11.21.10.50.21.11.21.1-1.81.6
Time in novel zone, hab. session 21.41.43.4-1.2-1.0-0.20.1-1.2-1.1-1.01.9-1.7
Total zone transitions, hab. session 20.10.10.30.40.3-0.3-0.40.60.1-0.0-0.30.3
Total locomotion distance, hab. session 20.40.61.21.01.10.30.61.00.60.8-0.40.7
Locomotion velocity, hab. session 20.40.51.20.91.10.20.51.00.50.8-0.40.6
Novel to familiar place preference ratio0.30.30.70.40.40.80.80.50.40.5-0.20.3
Novelty place preference0.10.10.30.20.10.60.60.30.30.3-0.10.1
Time in novel zone, NPP test0.10.10.30.10.10.50.50.30.30.10.0-0.0
Total zone transitions, NPP test0.10.10.40.50.5-0.10.00.60.00.00.1-0.1
Total locomotion distance, NPP test0.91.22.41.41.60.81.21.51.00.8-0.40.5
Locomotion velocity, NPP test0.50.71.41.11.20.50.81.10.50.8-0.30.5
Intraocular pressure0.40.51.30.70.61.00.50.10.11.2-0.60.8
Delta distance traveled before/after self-admin0.10.10.3-0.3-0.6-0.6-0.5-0.5-0.1-0.40.1-0.1
Delta ambulatory time before/after self-admin0.10.10.20.30.1-0.10.00.10.40.1-0.40.4
Parametrial fat weight1.22.34.61.51.91.92.11.71.21.4-0.20.7
Pavlov. Cond. lever latency2.93.75.3-2.0-2.2-2.0-2.3-2.2-2.2-1.51.3-1.3
Pavlov. Cond. magazine entry latency4.86.18.12.52.42.52.82.52.82.3-2.12.1
Pavlov. Cond. change in total contacts4.04.26.22.02.12.12.42.12.51.9-1.81.7
Pavlov. Cond. index score4.15.26.92.32.42.32.62.42.62.1-1.91.9
Pavlov. Cond. latency score3.34.25.72.12.22.02.32.22.41.8-1.81.7
Pavlov. Cond. lever contacts2.52.94.11.71.91.71.91.92.01.4-1.41.3
Pavlov. Cond. magazine entry number3.74.67.3-2.0-2.0-2.2-2.7-2.0-2.5-2.11.8-1.8
Pavlov. Cond. intertrial magazine entries0.70.81.90.90.60.40.30.60.51.3-1.31.4
Pavlov. Cond. lever-magazine prob. diff.3.74.66.52.12.22.32.52.22.51.9-1.81.7
Pavlov. Cond. response bias5.16.110.22.32.62.73.22.52.82.2-1.81.8
Pavlov. Cond. lever latency0.40.50.8-0.6-0.6-0.7-0.7-0.8-0.9-0.60.8-0.6
Pavlov. Cond. magazine entry latency2.73.24.3-1.9-1.6-1.8-2.0-1.6-1.7-2.11.5-1.7
Pavlov. Cond. change in total contacts0.40.61.40.70.60.30.20.80.90.6-1.20.9
Pavlov. Cond. index score0.00.00.1-0.1-0.0-0.1-0.20.10.2-0.4-0.1-0.1
Pavlov. Cond. latency score0.00.10.3-0.2-0.1-0.1-0.2-0.00.1-0.5-0.0-0.3
Pavlov. Cond. lever contacts0.30.40.60.60.60.50.60.70.80.5-0.70.6
Pavlov. Cond. magazine entry number3.23.95.52.01.82.02.11.71.82.3-1.82.1
Pavlov. Cond. intertrial magazine entries13.617.822.24.34.04.44.33.94.04.7-4.04.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.3-0.1-0.2-0.3-0.10.0-0.50.0-0.3
Pavlov. Cond. response bias0.00.00.00.10.2-0.00.00.20.2-0.1-0.20.0
Time in closed arm before self-admin0.70.81.5-0.9-0.8-0.9-0.6-0.8-0.5-1.11.0-1.2
Time in closed arm after self-admin0.60.71.7-0.5-0.3-1.1-0.90.1-0.4-1.30.7-1.1
Time in open arm before self-admin0.40.50.7-0.6-0.8-0.6-0.7-0.2-0.7-0.90.7-0.7
Time in open arm after self-admin0.10.10.3-0.1-0.30.2-0.2-0.5-0.40.6-0.20.5
Bone: periosteal estimation11.624.029.75.05.15.45.34.95.14.5-4.34.3
Bone: periosteal perimeter6.210.414.73.23.43.83.73.53.22.9-2.42.5
Bone: post-yield work2.43.24.42.02.01.81.52.11.71.5-1.71.7
Progressive ratio test 1 active lever presses5.15.36.12.52.42.32.32.42.22.4-2.22.1
Progressive ratio test 1 breakpoint6.46.67.62.72.62.62.52.52.52.8-2.52.4
Progressive ratio test 1 inactive lever presses5.15.56.22.42.32.42.32.32.42.5-2.42.3
Progressive ratio test 2 active lever presses6.06.57.42.72.72.62.62.62.32.7-2.32.4
Progressive ratio test 2 breakpoint6.97.78.92.93.02.92.82.82.62.9-2.52.6
Progressive ratio test 2 inactive lever presses4.95.67.12.52.62.32.42.42.12.7-2.12.3
Incentive Sensitization - Responses3.94.04.72.12.12.01.92.21.82.1-1.72.1
Incentive Sensitization - Breakpoint3.73.84.82.12.11.91.82.21.81.9-1.72.0
Sum of active levers in priming session hrs 5-60.40.41.2-0.8-0.9-0.5-0.7-1.1-0.6-0.30.1-0.2
Progressive ratio0.10.10.2-0.1-0.2-0.4-0.2-0.2-0.5-0.10.30.0
Food seeking constrained by brief footshock3.84.77.62.42.21.61.42.32.22.0-2.82.3
Seeking ratio, punishment vs. effort1.62.03.41.41.41.21.01.51.71.2-1.81.3
Retroperitoneal fat weight1.65.18.62.82.71.81.82.92.02.2-1.81.9
Reaction time number correct1.01.42.7-1.0-0.7-0.8-1.0-0.7-1.4-1.41.6-1.4
Reaction time mean minus median0.30.41.0-0.6-0.7-0.5-0.5-1.0-0.6-0.50.4-0.3
Reaction time mean minus median AUC1.31.62.5-1.4-1.3-1.2-1.1-1.6-1.3-1.31.2-1.2
Reaction time num false alarms3.44.65.22.32.22.32.02.22.21.9-2.21.8
Reaction time num false alarms AUC3.85.36.22.42.42.52.32.42.42.1-2.22.0
Reaction time trials correct on left1.01.42.7-1.0-0.7-0.8-1.0-0.7-1.4-1.41.6-1.4
Reaction time trials on left0.91.32.7-1.0-0.7-0.7-0.9-0.7-1.4-1.41.6-1.4
Reaction time mean0.60.81.8-1.0-1.2-0.9-0.6-1.3-0.6-0.90.7-0.8
Reaction time mean AUC0.91.22.6-1.2-1.4-1.0-0.8-1.6-0.7-1.10.7-0.9
Median of all reaction times0.60.81.6-1.0-1.2-0.9-0.5-1.3-0.5-0.90.7-0.8
Reaction time omissions0.10.10.60.0-0.10.60.7-0.50.10.10.2-0.1
Reaction time false alarm rate4.36.17.62.52.32.52.42.32.82.3-2.72.3
Reaction time premature initiation rate0.91.22.00.91.31.31.20.80.91.4-0.61.0
Reaction time premature initiations0.20.30.70.40.90.80.60.40.10.60.20.2
Std. dev. reaction times0.30.41.2-0.7-0.8-0.6-0.4-1.1-0.5-0.60.4-0.4
Reaction time trials completed0.91.32.7-1.0-0.7-0.7-0.9-0.7-1.4-1.41.6-1.4
Reaction time trials AUC1.01.42.7-1.0-0.7-0.8-1.0-0.7-1.5-1.41.6-1.4
Run reversals in cocaine runway, females0.40.41.1-0.6-0.5-0.2-0.2-0.5-0.8-0.41.1-0.7
Run reversals in cocaine runway, males0.10.10.2-0.4-0.3-0.1-0.2-0.3-0.3-0.30.4-0.4
Latency to leave start box in cocaine runway0.40.40.6-0.8-0.7-0.5-0.6-0.6-0.5-0.60.6-0.7
Latency to leave start box in cocaine runway, F0.70.81.2-1.0-0.8-0.7-0.7-0.9-0.7-1.00.7-1.1
Latency to leave start box in cocaine runway, M0.00.00.1-0.1-0.2-0.1-0.20.0-0.00.00.10.1
Std. dev. time between licks in bursts0.00.00.2-0.1-0.2-0.1-0.1-0.4-0.30.3-0.10.2
Total sessions with >9 infusions0.10.10.20.50.50.30.40.40.10.4-0.10.2
Short access day 1 total inactive lever presses1.11.32.01.21.41.21.21.41.10.9-0.70.7
Short access day 10 total inactive lever presses0.60.61.20.60.60.90.80.30.71.1-0.91.0
Short access day 1 total infusions0.90.91.31.01.00.91.00.90.81.2-0.90.9
Short access day 10 total infusions6.26.98.32.82.82.72.62.42.52.9-2.52.5
Short access total infusions3.64.04.52.12.12.12.11.72.02.1-1.91.8
Short access day 1 locomotion3.33.65.32.02.02.01.91.61.62.3-1.71.8
Short access day 10 total locomotion12.213.616.64.04.13.53.33.73.53.8-3.73.6
Short access total locomotion5.86.07.62.72.72.42.22.32.32.6-2.52.3
One hour access (0.3 mA shock)1.11.21.71.21.11.10.91.01.11.1-1.31.2
Compulsive drug intake1.11.12.0-1.0-1.0-0.8-0.8-0.6-1.0-1.41.3-1.4
One hour access (shock baseline)1.61.92.91.51.41.10.91.21.31.5-1.61.7
Social response proportion0.40.51.0-0.6-0.5-0.6-1.0-0.5-0.9-0.70.7-0.6
Social responses0.00.00.20.20.40.1-0.00.30.10.2-0.10.1
Social time0.00.00.20.10.30.4-0.00.10.00.20.10.1
Soleus weight0.10.30.60.40.80.80.50.60.50.3-0.20.4
Bone: stiffness0.71.11.61.31.11.01.01.30.91.0-0.90.9
Tibialis anterior weight0.10.31.00.10.1-0.3-0.70.0-0.20.6-0.51.0
Time to tail flick, vehicle, before self-admin0.10.10.4-0.4-0.20.1-0.0-0.0-0.3-0.60.4-0.6
Time to tail flick, vehicle, after self-admin0.50.51.50.40.61.01.00.40.41.2-0.50.6
Time to tail flick, test, before self-admin0.70.71.2-0.8-0.6-1.0-1.1-0.6-0.8-0.90.7-0.7
Time to tail flick, test, after self-admin0.10.10.3-0.5-0.3-0.10.2-0.3-0.30.00.2-0.4
Delta time to tail flick, vehicle, before/after SA2.22.24.21.41.41.51.71.01.32.0-1.21.6
Delta time to tail flick, test, before/after SA0.10.00.2-0.1-0.20.20.5-0.10.00.3-0.1-0.0
Tibia length0.10.40.70.40.80.30.40.8-0.1-0.50.8-0.8
Ambulatory time before self-admin0.10.20.4-0.4-0.2-0.0-0.4-0.2-0.4-0.50.3-0.7
Ambulatory time after self-admin0.10.10.20.20.30.30.10.00.40.0-0.40.1
Bone: tissue strength1.31.21.8-0.9-0.7-1.1-1.1-0.8-1.2-1.31.2-1.3
Total heroin consumption0.60.71.30.70.81.00.90.71.20.4-1.00.6
Bone: trabecular number3.35.210.92.12.32.93.32.22.32.0-1.11.2
Bone: trabecular spacing1.11.54.4-1.0-1.2-1.8-2.1-1.0-1.1-0.90.2-0.3
Bone: trabecular thickness3.84.610.21.92.23.03.22.02.01.9-0.91.2
Bone: trabecular tissue density1.11.63.2-1.2-0.9-0.9-0.6-1.2-1.5-1.11.8-1.7
Water consumed over 24 hours0.10.10.50.40.70.30.30.60.2-0.00.1-0.0
Number of responses in last shaping day1.01.01.81.01.11.41.30.91.01.0-0.80.7