Hub : Genes

Scn1b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Scn1b 0.41 0.19 8.0e-03 -0 0.08 0.01 0.03 3.7e-01 5.8e-03 1.5e-01 8.5e-02
2 Liver gene expression Scn1b 0.35 0.12 0.0e+00 0.2 0.21 0.21 0.2 5.0e-22 1.0e-22 2.7e-23 3.2e-22
3 Brain alternative TSS NM_001271046.2 0.23 0.1 6.6e-08 0.1 0.07 0.03 0.09 2.6e-09 5.8e-07 5.0e-04 7.7e-09
4 Brain alternative TSS NM_017288.3 0.23 0.11 9.2e-08 0.1 0.07 0.05 0.09 3.2e-09 9.3e-07 4.0e-05 8.4e-09
5 Brain isoform ratio NM_001271046.2 0.22 0.1 4.0e-08 0.1 0.06 0.06 0.09 1.6e-09 1.4e-06 3.7e-06 6.2e-09
6 PL gene expression Scn1b 0.15 0.08 8.9e-07 0.06 0.07 0.07 0.06 1.0e-07 9.6e-08 2.1e-08 2.8e-07
7 Brain mRNA stability Scn1b 0.1 0.06 2.8e-03 0.04 0.03 0.03 0.02 1.8e-04 1.5e-03 1.4e-03 2.3e-03
8 Brain isoform ratio NM_017288.3 0.23 0.1 1.4e-09 0.1 0.09 0.1 0.1 1.1e-09 6.9e-09 8.1e-10 1.0e-09
9 OFC alternative TSS NM_001271046.2 0.36 0.18 1.6e-03 0.08 0.08 0.11 0.11 5.5e-03 4.9e-03 1.7e-03 1.3e-03
10 Brain gene expression Scn1b 0.19 0.08 6.6e-09 0.08 0.08 0.08 0.08 4.9e-08 3.3e-08 9.2e-08 6.5e-08
11 Brain isoform ratio NM_001271045.2 0.08 0.05 4.0e-10 0.11 0.12 0.11 0.12 9.4e-11 5.6e-11 1.3e-10 4.8e-11
12 NAcc gene expression Scn1b 0.03 0.03 7.6e-03 0 0.01 0.01 0.01 1.4e-01 1.2e-02 4.0e-02 5.4e-02
13 BLA gene expression Scn1b 0.26 0.14 1.4e-04 0.09 0.06 0.12 0.06 2.1e-05 2.2e-04 4.5e-07 3.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.40.62.6-1.00.20.7-0.70.70.10.60.10.30.51.61.0-1.1
Area under the delay curve0.80.83.9-0.30.70.7-0.70.70.81.0-0.8-0.8-0.9-0.3-0.72.0
BMI with tail0.00.10.60.8-0.3-0.20.2-0.2-0.1-0.00.0-0.30.0-0.4-0.10.2
BMI without tail0.00.10.2-0.1-0.4-0.30.3-0.3-0.20.10.4-0.00.2-0.2-0.0-0.3
Body weight0.93.812.9-3.61.92.2-2.22.21.72.4-0.7-0.9-1.02.60.6-0.3
Weight adjusted by age0.20.30.8-0.90.60.6-0.60.60.60.3-0.3-0.7-0.3-0.0-0.20.3
Bone surface1.32.24.5-2.11.61.9-1.91.91.71.8-1.2-1.2-1.20.6-0.50.2
Bone volume1.11.94.4-2.11.51.7-1.71.71.41.7-1.0-0.9-0.81.1-0.1-0.2
Breakpoint value in progressive ratio session1.01.21.7-0.91.31.3-1.31.31.01.3-1.2-1.2-1.20.2-0.70.7
Number of licking bursts0.70.84.31.4-0.3-0.50.5-0.50.1-0.2-0.5-0.5-0.7-2.1-1.40.5
Context. condit. distance diff. score0.80.91.6-0.40.81.0-1.01.00.90.4-1.1-0.9-1.2-1.0-1.21.2
Locomotion velocity, session 10.10.10.60.3-0.30.1-0.10.1-0.1-0.40.20.50.80.30.60.1
Locomotion distance, session 14.05.17.5-2.12.62.7-2.72.72.62.2-2.5-2.3-1.8-0.7-1.61.8
Locomotion velocity, session 20.10.10.70.5-0.1-0.00.0-0.00.30.2-0.2-0.30.2-0.8-0.30.7
Locomotion distance, session 23.14.46.7-0.52.12.1-2.12.12.41.9-2.6-2.6-1.7-2.2-2.12.0
Locomotion velocity, session 30.70.81.7-0.40.70.9-0.90.91.10.8-0.9-1.1-0.5-1.1-0.91.3
Locomotion distance, session 39.410.313.1-2.73.43.6-3.63.63.63.6-3.2-3.4-3.0-1.0-2.53.4
Stereotopy head waving bouts, day 34.24.96.31.8-2.4-2.32.3-2.3-2.5-2.12.32.22.41.12.2-2.5
Stereotopy head waving duration, day 34.65.58.22.2-2.6-2.32.3-2.3-2.6-2.62.32.42.50.92.1-2.9
Locomotion velocity, session 72.93.15.5-1.42.01.9-1.91.92.01.8-1.9-1.7-1.7-0.4-1.22.4
Locomotion distance, session 71.51.93.0-1.61.71.6-1.61.61.71.4-1.4-1.4-1.1-0.2-0.81.2
Stereotopy head waving bouts, day 70.50.62.81.0-0.4-0.60.6-0.6-0.1-0.2-0.2-0.5-0.4-1.7-1.11.0
Stereotopy head waving duration, day 71.01.23.71.9-1.3-1.31.3-1.3-1.1-1.20.60.50.6-1.1-0.10.3
Locomotion velocity, session 81.01.25.91.20.30.3-0.30.30.6-0.2-1.2-0.9-0.7-2.4-1.61.5
Locomotion distance, session 83.85.58.1-0.72.22.3-2.32.32.51.6-2.8-2.6-2.3-2.7-2.82.5
Degree of sensitization distance2.93.04.21.0-1.6-1.91.9-1.9-1.8-2.01.82.01.50.91.4-2.0
Degree of sensitization stereotypy0.90.94.30.9-0.1-0.30.3-0.30.30.0-0.6-0.9-0.9-2.1-1.51.6
Conditioned locomotion0.40.52.01.4-0.8-0.80.8-0.8-0.7-0.50.40.20.3-0.50.0-0.2
Cocaine response after cond. corrected3.43.85.21.4-2.2-1.91.9-1.9-2.2-1.72.32.32.11.52.1-1.4
Cocaine response after cond. not corrected4.54.96.91.3-2.5-2.22.2-2.2-2.4-2.12.62.62.51.62.3-1.9
Cocaine response before conditioning0.40.52.6-1.60.90.6-0.60.60.80.4-0.5-0.4-0.6-0.2-0.60.0
Saline control response0.10.10.30.0-0.3-0.20.2-0.2-0.0-0.20.40.20.50.30.40.1
Bone: connectivity density0.20.30.6-0.70.40.8-0.80.80.40.7-0.3-0.3-0.10.50.2-0.5
Bone: cortical apparent density0.30.41.10.80.20.5-0.50.50.30.0-0.8-0.4-0.3-0.9-0.61.0
Bone: cortical area0.40.62.6-1.60.90.8-0.80.80.70.8-0.3-0.2-0.30.80.10.1
Bone: cortical porosity1.31.46.80.90.30.1-0.10.10.60.1-1.0-1.1-1.0-2.6-1.91.9
Bone: cortical porosity1.51.77.31.00.40.2-0.20.20.70.3-1.2-1.3-1.1-2.7-2.02.0
Bone: cortical thickness0.10.20.8-0.6-0.1-0.20.2-0.2-0.30.10.50.60.50.90.7-0.3
Bone: cortical thickness0.40.51.00.7-0.7-0.70.7-0.7-0.7-0.70.60.71.00.20.7-0.4
Bone: cortical tissue density0.30.41.20.90.20.5-0.50.50.30.0-0.8-0.4-0.3-1.0-0.61.1
Condit. Reinf. active minus inactive responses0.10.10.20.30.10.3-0.30.30.20.3-0.3-0.40.1-0.3-0.10.4
Condit. Reinf. active-inactive response ratio1.21.32.31.1-1.4-0.90.9-0.9-1.2-0.81.31.11.50.91.5-0.8
Condit. Reinf. active responses0.30.41.51.20.10.2-0.20.20.20.3-0.7-0.7-0.1-1.1-0.50.8
Condit. Reinf. inactive responses1.51.73.40.71.21.0-1.01.01.20.9-1.9-1.5-1.3-1.8-1.61.5
Incentive salience index mean0.30.40.60.20.50.7-0.70.70.50.7-0.8-0.7-0.3-0.5-0.40.7
Condit. Reinf. lever presses0.50.71.3-0.00.81.0-1.01.00.80.8-1.1-0.8-0.7-0.5-0.71.1
Condit. Reinf. active minus inactive responses1.21.52.8-1.71.61.5-1.51.51.41.0-1.2-1.0-0.80.2-0.50.3
Condit. Reinf. active-inactive response ratio0.10.10.1-0.20.40.3-0.30.30.1-0.3-0.4-0.1-0.1-0.2-0.2-0.1
Condit. Reinf. active responses2.33.26.3-2.52.22.1-2.12.12.11.9-1.7-1.6-1.50.3-0.91.0
Condit. Reinf. inactive responses2.93.55.0-2.22.01.9-1.91.92.22.2-1.7-1.7-2.0-0.1-1.42.1
Condit. Reinf. lever presses2.63.610.5-3.22.22.4-2.42.41.91.9-1.3-1.2-1.21.5-0.10.1
Condit. Reinf. lever reinforcers received3.34.77.7-2.82.62.5-2.52.52.52.3-2.1-2.0-2.00.0-1.41.4
Conditioned reinforcement - actives0.10.10.40.10.20.1-0.10.10.2-0.1-0.5-0.2-0.2-0.6-0.50.6
Conditioned reinforcement - inactives5.25.99.1-1.32.62.5-2.52.52.52.1-3.0-2.4-2.8-1.8-2.62.4
Conditioned locomotion0.60.72.81.50.10.0-0.00.00.10.0-0.9-0.5-0.6-1.7-1.01.3
Patch foraging indifference point 0 sec0.10.10.5-0.00.00.4-0.40.40.20.2-0.2-0.2-0.3-0.6-0.50.7
Patch foraging indifference point AUC0.60.71.31.0-1.0-0.80.8-0.8-1.1-0.90.71.10.80.20.7-0.1
Delay disc. indifference point, 0s delay3.33.66.0-0.72.02.1-2.12.11.92.0-2.3-2.0-2.1-0.6-1.52.5
Delay disc. indifference point, 16s delay0.60.62.9-0.10.60.7-0.70.70.71.0-0.8-0.6-0.9-0.1-0.61.7
Delay disc. indifference point, 2s delay3.03.34.7-1.52.02.2-2.22.21.92.1-1.9-1.8-1.80.2-1.01.9
Delay disc. indifference point, 24s delay1.81.73.5-1.31.41.5-1.51.51.21.6-1.2-0.7-1.30.4-0.61.9
Delay disc. indifference point, 4s delay0.60.71.50.10.60.6-0.60.60.80.7-0.9-0.9-0.9-1.1-1.11.2
Delay disc. indifference point, 8s delay0.20.32.6-0.30.0-0.10.1-0.10.20.40.1-0.1-0.4-0.3-0.41.6
Indifference point function ln k1.21.62.7-1.51.51.5-1.51.51.61.4-1.2-1.6-0.9-0.4-0.90.2
Indifference point function log k1.21.62.7-1.51.51.5-1.51.51.61.4-1.2-1.6-0.9-0.4-0.90.2
Patch foraging total patch changes 0 sec0.10.20.7-0.20.20.5-0.50.50.30.4-0.4-0.3-0.5-0.5-0.60.8
Patch foraging total patch changes 12 sec0.30.41.00.6-0.9-0.60.6-0.6-0.8-1.00.70.90.6-0.10.40.4
Patch foraging total patch changes 18 sec0.10.21.10.2-0.3-0.10.1-0.1-0.20.2-0.00.2-0.4-0.7-0.61.0
Patch foraging total patch changes 24 sec0.50.61.6-0.70.60.9-0.90.90.51.1-0.6-0.3-1.10.1-0.61.3
Patch foraging total patch changes 6 sec0.10.10.30.4-0.4-0.20.2-0.2-0.5-0.50.30.50.2-0.00.20.1
Patch foraging time to switch 0 sec3.55.47.82.4-2.8-2.82.8-2.8-2.7-2.32.52.32.00.71.6-1.5
Patch foraging water rate 0 sec0.91.42.6-0.21.31.3-1.31.31.40.8-1.6-1.4-0.8-1.3-1.10.7
Patch foraging water rate 12 sec2.53.85.3-2.22.32.0-2.02.02.21.7-2.0-2.1-2.0-1.2-2.00.7
Patch foraging water rate 18 sec0.30.50.7-0.30.70.7-0.70.70.80.5-0.9-0.8-0.4-0.8-0.70.0
Patch foraging water rate 24 sec7.410.315.1-2.03.43.3-3.33.33.63.0-3.6-3.9-3.2-2.6-3.42.5
Patch foraging water rate 6 sec5.07.39.7-2.43.13.1-3.13.13.12.9-2.9-2.9-2.6-1.0-2.21.7
Seeking ratio, delayed vs. immediate footshock3.03.45.3-1.62.21.8-1.81.81.91.8-2.0-1.9-2.0-0.5-1.52.3
Distance traveled before self-admin0.10.10.20.1-0.3-0.30.3-0.3-0.0-0.10.40.40.10.10.10.0
Distance traveled after self-admin1.31.54.6-2.11.51.2-1.21.21.41.2-0.8-1.2-1.40.2-0.90.4
Extensor digitorum longus weight0.62.36.10.9-1.2-0.80.8-0.8-1.5-0.91.41.71.82.22.5-1.8
Bone: elastic displacement0.60.71.30.3-0.9-0.90.9-0.9-1.0-0.71.10.90.80.50.8-0.9
Bone: elastic work0.30.42.0-1.30.40.3-0.30.30.10.50.20.3-0.11.40.6-0.3
Bone: endosteal estimation0.92.04.9-2.21.71.7-1.71.71.71.5-1.1-1.2-1.10.2-0.70.4
Bone: endosteal perimeter1.12.34.1-2.01.71.7-1.71.71.81.8-1.3-1.4-1.4-0.1-1.00.4
Epididymis fat weight0.51.21.8-1.31.41.2-1.21.21.31.1-1.2-1.1-1.0-0.2-0.8-0.0
Delta time in closed arm before/after self-admin0.70.72.4-1.50.60.8-0.80.80.40.90.10.1-0.21.50.60.9
Delta time in open arm before/after self-admin0.50.51.40.7-0.7-0.70.7-0.7-0.5-1.00.30.60.4-0.9-0.2-1.2
Diff in mean of infusions in LGA sessions0.30.31.11.0-0.4-0.50.5-0.5-0.1-0.2-0.00.1-0.3-1.0-0.70.6
Delay discount exponential model param0.60.62.90.4-0.6-0.60.6-0.6-0.7-1.00.60.70.80.20.6-1.7
Extinction: sum of active levers before priming0.90.85.0-1.20.20.3-0.30.3-0.30.40.60.50.32.21.3-1.2
Active lever presses in extinction session 62.32.37.7-0.6-1.0-0.90.9-0.9-1.5-0.71.81.61.62.82.3-1.2
Bone: final force0.71.23.1-1.81.31.2-1.21.21.11.4-0.8-0.7-0.90.8-0.10.6
Bone: final moment0.91.44.3-2.11.51.4-1.41.41.11.4-0.8-0.7-0.91.0-0.10.6
Food consumed during 24 hour testing period2.22.63.4-1.41.61.8-1.81.81.81.5-1.6-1.8-1.7-1.1-1.71.2
Glucose0.61.01.60.4-1.1-1.11.1-1.1-1.0-1.31.21.21.00.30.8-0.3
Heart weight1.82.54.1-1.21.92.0-2.02.01.80.9-2.0-1.4-1.5-0.6-1.21.4
Delay discount hyperbolic model param0.70.83.00.4-0.8-0.80.8-0.8-0.8-1.10.80.80.90.20.6-1.7
Intermittent access intake day 1-15 change0.90.82.5-1.61.01.0-1.01.00.81.0-0.4-0.6-0.71.10.10.7
Intermittent access intake escalation1.21.22.6-1.61.21.3-1.31.31.01.2-0.7-0.9-0.91.0-0.11.0
Intermittent access intake escalation 20.20.20.9-1.00.10.1-0.10.10.10.30.30.1-0.10.80.30.4
Intermitt. access day 1 inactive lever presses0.50.51.5-1.10.80.8-0.80.80.50.8-0.3-0.3-0.51.20.30.7
Intermitt. access day 15 inactive lever presses0.91.01.6-0.31.11.2-1.21.20.90.9-1.2-1.0-1.1-0.1-0.71.3
Intermitt. access escalation Index0.70.61.1-0.10.50.6-0.60.60.80.9-0.8-0.7-0.9-1.0-1.10.8
Intermittent access day 1 total infusions1.82.07.80.80.80.6-0.60.60.90.7-1.7-1.4-1.6-2.8-2.31.6
Intermittent access day 15 total infusions3.33.76.1-0.61.81.7-1.71.71.81.8-2.2-2.1-2.3-1.9-2.42.5
Intermittent access terminal intake (last 3 days)2.93.26.4-0.31.51.3-1.31.31.71.5-2.1-1.9-2.1-2.5-2.52.1
Intermittent access total infusions2.73.08.0-0.11.31.0-1.01.01.51.3-2.0-1.8-2.1-2.8-2.71.8
Intermittent access day 1 locomotion2.32.45.50.51.21.1-1.11.11.31.2-2.0-1.6-1.8-2.3-2.21.5
Intermittent access day 15 total locomotion3.53.85.7-0.72.01.9-1.91.91.91.7-2.4-2.2-2.3-1.8-2.22.0
Intermittent access total locomotion1.21.44.50.70.60.6-0.60.60.80.8-1.4-1.1-1.3-2.1-1.71.4
Intermittent access standard deviation3.13.25.7-2.42.11.6-1.61.61.82.0-1.5-2.0-2.1-0.0-1.42.1
Left kidney weight1.02.815.9-2.30.31.0-1.01.0-0.00.70.91.20.74.02.4-1.7
Right kidney weight1.43.917.2-3.31.11.9-1.91.90.81.50.30.30.14.12.0-1.7
Cocaine induced anxiety0.30.42.2-0.1-0.10.3-0.30.3-0.3-0.30.30.70.41.51.1-0.4
Post-drug Anxiety1.41.62.91.4-1.3-1.01.0-1.0-1.5-1.41.11.71.31.21.5-0.8
Baseline Anxiety0.50.51.61.3-0.6-0.90.9-0.9-0.4-0.50.10.10.1-1.2-0.50.6
Tail length0.82.613.0-3.61.41.6-1.61.61.01.6-0.1-0.2-0.62.30.6-0.8
Length with tail2.59.032.6-5.73.33.5-3.53.52.73.5-1.4-1.4-1.93.20.2-0.0
Length without tail3.26.916.8-4.13.23.2-3.23.22.72.9-1.9-1.7-2.02.2-0.20.8
Times rat made contact with spout0.50.51.60.1-0.5-0.50.5-0.5-0.7-1.10.70.50.90.50.8-1.3
Lifetime Intake1.61.85.7-0.11.00.8-0.80.81.10.9-1.6-1.4-1.5-2.4-2.21.3
Liver weight, left0.81.22.00.8-1.2-1.01.0-1.0-1.2-1.21.11.31.40.91.3-1.1
Liver weight, right0.10.10.50.2-0.2-0.10.1-0.1-0.0-0.40.20.20.70.30.6-0.1
Locomotor activity1.11.73.60.8-1.3-1.21.2-1.2-1.2-1.61.31.31.70.51.3-1.9
Locomotor testing distance0.50.81.60.5-0.9-0.80.8-0.8-0.8-1.20.91.01.1-0.10.6-1.3
Locomotor testing rearing0.20.31.70.6-0.2-0.40.4-0.4-0.0-0.8-0.1-0.00.4-1.3-0.5-0.4
Locomotion in novel chamber0.70.91.61.1-1.1-1.01.0-1.0-1.0-1.30.90.81.0-0.20.6-0.4
Locomotion in novel chamber post-restriction0.20.20.40.6-0.4-0.50.5-0.5-0.5-0.50.40.30.50.10.4-0.4
Fecal boli incidents, locomotor time 12.12.35.12.3-1.9-1.71.7-1.7-1.8-1.51.31.61.5-0.11.0-0.4
Change in fecal boli incidents, locomotor task1.51.42.70.4-0.9-1.11.1-1.1-1.3-1.21.31.21.41.41.6-1.3
Time >=10cm from walls, locomotor time 10.10.10.10.1-0.3-0.30.3-0.3-0.2-0.30.20.30.3-0.00.10.1
Bouts of movement, locomotor time 13.13.34.2-1.21.92.0-2.02.01.92.0-2.0-1.7-2.0-0.9-1.71.9
Total resting periods, locomotor time 11.81.92.5-0.91.41.6-1.61.61.51.6-1.5-1.3-1.6-0.7-1.31.4
Rest time, locomotor task time 11.21.33.31.8-1.3-1.11.1-1.1-1.4-1.10.91.51.20.51.1-0.0
Distance moved, locomotor task time 10.70.81.6-1.11.00.8-0.80.81.20.8-0.7-1.2-0.9-0.6-0.90.3
Vertical activity count, locomotor time 11.71.83.7-1.91.71.4-1.41.41.51.5-1.1-1.5-1.4-0.2-1.10.3
Time >=10cm from walls, locomotor time 20.40.41.41.2-0.6-0.60.6-0.6-0.5-0.60.10.40.3-1.2-0.40.3
Bouts of movement, locomotor time 20.40.41.1-0.60.50.4-0.40.40.60.4-0.5-0.5-0.7-1.0-1.00.4
Total resting periods, locomotor time 20.20.21.2-0.20.1-0.00.0-0.00.3-0.0-0.2-0.2-0.4-1.1-0.90.2
Rest time, locomotor task time 20.70.81.71.3-1.1-1.01.0-1.0-1.1-1.00.71.10.8-0.10.6-0.6
Distance moved, locomotor task time 21.21.42.2-1.01.21.2-1.21.21.51.1-1.2-1.5-1.2-0.9-1.31.0
Vertical activity count, locomotor time 22.02.23.0-1.71.71.7-1.71.71.71.7-1.4-1.5-1.5-0.2-1.10.7
Light reinforcement 10.50.91.8-0.30.90.5-0.50.51.20.9-1.0-1.3-1.0-1.3-1.30.8
Light reinforcement 20.20.31.31.20.0-0.00.0-0.00.4-0.4-0.5-0.70.2-1.1-0.30.2
Bone: marrow area0.81.74.5-2.11.51.6-1.61.61.51.4-1.0-1.0-1.00.3-0.60.3
Bone: maximum diameter0.30.62.2-1.50.91.0-1.01.00.70.8-0.4-0.1-0.40.90.10.0
Bone: maximum force1.42.45.7-2.41.81.8-1.81.81.62.0-1.2-1.1-1.21.0-0.31.0
Bone: maximum moment1.62.87.1-2.72.01.9-1.91.91.72.0-1.3-1.1-1.31.1-0.31.0
Mean time between licks in bursts0.71.01.6-0.51.11.0-1.01.01.30.6-1.2-1.2-0.9-0.9-1.10.4
Mean num. licks in bursts0.80.94.3-1.20.10.3-0.30.3-0.3-0.30.70.61.12.11.6-1.0
Cd content in liver0.40.51.00.0-0.8-0.90.9-0.9-0.8-0.81.00.90.40.30.4-0.3
Co content in liver0.60.71.11.0-0.8-1.11.1-1.1-0.9-0.70.80.70.70.30.7-0.7
Cu content in liver0.40.40.9-0.80.90.8-0.80.80.60.7-0.7-0.3-0.50.80.10.0
Fe content in liver0.10.10.60.20.0-0.40.4-0.4-0.2-0.6-0.00.2-0.1-0.4-0.20.8
K content in liver0.00.00.10.20.10.0-0.00.00.30.2-0.2-0.2-0.0-0.3-0.10.1
Mg content in liver0.30.31.01.0-0.4-0.40.4-0.4-0.3-0.50.20.30.7-0.00.5-0.6
Mn content in liver2.12.43.61.6-1.9-1.71.7-1.7-1.7-1.91.61.51.7-0.20.9-1.3
Na content in liver1.61.62.6-1.31.41.6-1.61.61.51.1-1.3-1.1-1.3-0.2-1.01.0
Rb content in liver0.30.31.30.40.60.4-0.40.40.50.4-0.8-0.7-0.6-0.3-0.41.1
Se content in liver2.32.89.03.0-2.0-1.71.7-1.7-1.6-2.11.01.31.8-0.80.9-0.5
Sr content in liver1.31.22.20.9-1.0-1.51.5-1.5-1.1-1.41.01.00.9-0.40.3-0.8
Zn content in liver0.10.10.20.50.10.1-0.10.1-0.1-0.1-0.10.00.20.40.40.0
Bone: minimum diameter2.13.96.3-2.52.32.2-2.22.22.22.4-1.8-1.6-2.0-0.0-1.31.5
Time in familiar zone, hab. session 11.00.95.0-0.80.10.6-0.60.6-0.20.10.40.80.92.21.7-0.9
Time in novel zone, hab. session 11.31.37.11.1-0.2-0.70.7-0.70.3-0.2-0.4-0.9-0.8-2.7-1.81.3
Total zone transitions, hab. session 11.62.24.4-0.91.61.4-1.41.41.71.1-1.7-1.6-1.4-1.2-1.52.1
Total locomotion distance, hab. session 10.60.91.9-1.21.00.6-0.60.60.90.6-0.8-1.0-1.0-1.2-1.40.5
Locomotion velocity, hab. session 10.10.20.7-0.70.30.1-0.10.10.30.1-0.2-0.3-0.4-0.8-0.8-0.1
Time in familiar zone, hab. session 21.81.93.50.1-1.2-0.90.9-0.9-1.5-1.21.61.81.31.71.6-1.9
Time in novel zone, hab. session 20.60.61.60.00.50.3-0.30.30.80.6-0.8-1.1-0.6-1.2-1.01.3
Total zone transitions, hab. session 21.01.37.00.70.60.4-0.40.41.00.1-1.3-1.4-0.6-2.6-1.71.0
Total locomotion distance, hab. session 20.91.25.2-0.10.80.4-0.40.40.90.3-1.1-1.2-1.1-2.3-1.90.8
Locomotion velocity, hab. session 20.60.84.20.10.50.2-0.20.20.70.1-0.8-1.0-0.8-2.0-1.60.4
Novel to familiar place preference ratio0.20.20.3-0.30.50.3-0.30.30.40.5-0.4-0.5-0.6-0.1-0.40.4
Novelty place preference0.20.20.5-0.30.50.3-0.30.30.50.5-0.5-0.6-0.7-0.4-0.60.5
Time in novel zone, NPP test0.30.30.6-0.30.50.3-0.30.30.60.4-0.6-0.7-0.7-0.6-0.80.6
Total zone transitions, NPP test0.81.11.7-0.81.11.1-1.11.11.31.1-1.1-1.2-0.6-0.7-0.81.3
Total locomotion distance, NPP test0.71.04.3-2.11.10.9-0.90.91.11.1-0.5-0.8-0.8-0.0-0.70.1
Locomotion velocity, NPP test0.40.63.5-1.90.80.7-0.70.70.80.8-0.3-0.5-0.50.1-0.4-0.2
Intraocular pressure0.20.20.80.5-0.4-0.60.6-0.6-0.3-0.20.2-0.0-0.3-0.9-0.60.3
Delta distance traveled before/after self-admin1.81.95.4-2.31.71.6-1.61.61.31.5-1.0-1.3-1.40.5-0.70.4
Delta ambulatory time before/after self-admin2.42.66.5-2.52.01.8-1.81.81.61.8-1.3-1.7-1.60.5-0.80.3
Parametrial fat weight3.56.812.21.0-2.5-2.02.0-2.0-2.5-2.12.92.83.23.03.5-3.3
Pavlov. Cond. lever latency0.60.72.90.0-0.6-0.60.6-0.6-0.8-0.31.01.00.61.71.3-0.8
Pavlov. Cond. magazine entry latency0.70.85.3-0.30.40.1-0.10.10.90.3-0.5-1.2-0.4-2.3-1.6-0.3
Pavlov. Cond. change in total contacts2.93.07.2-0.51.51.2-1.21.21.91.4-1.9-2.3-1.6-2.7-2.51.5
Pavlov. Cond. index score0.70.95.4-0.00.50.2-0.20.20.90.3-0.8-1.2-0.4-2.3-1.6-0.0
Pavlov. Cond. latency score0.81.04.8-0.20.70.5-0.50.51.00.5-1.0-1.4-0.7-2.2-1.70.5
Pavlov. Cond. lever contacts0.60.72.2-0.30.70.6-0.60.60.90.6-0.9-1.1-0.7-1.5-1.30.6
Pavlov. Cond. magazine entry number0.91.16.10.3-0.6-0.30.3-0.3-1.0-0.50.81.50.62.51.80.1
Pavlov. Cond. intertrial magazine entries0.10.10.30.60.10.5-0.50.5-0.0-0.0-0.50.10.20.40.4-0.3
Pavlov. Cond. lever-magazine prob. diff.0.91.16.70.00.50.3-0.30.31.00.4-0.9-1.4-0.5-2.6-1.80.1
Pavlov. Cond. response bias0.30.42.7-0.30.30.0-0.00.00.70.2-0.3-0.9-0.1-1.6-1.0-0.4
Pavlov. Cond. lever latency3.34.48.52.9-2.5-2.62.6-2.6-2.3-2.61.71.81.7-1.00.7-0.8
Pavlov. Cond. magazine entry latency0.91.12.3-1.51.21.4-1.41.41.00.8-0.9-0.6-0.80.5-0.4-0.0
Pavlov. Cond. change in total contacts4.46.111.9-3.52.83.0-3.03.02.62.9-2.0-1.9-2.40.9-1.21.1
Pavlov. Cond. index score3.03.87.8-2.82.32.5-2.52.52.12.1-1.7-1.5-1.70.8-0.80.6
Pavlov. Cond. latency score2.83.56.6-2.62.22.4-2.42.42.02.0-1.6-1.4-1.60.7-0.80.7
Pavlov. Cond. lever contacts3.34.58.2-2.92.52.6-2.62.62.32.6-1.8-1.9-1.80.8-0.90.8
Pavlov. Cond. magazine entry number2.53.07.12.7-2.1-2.22.2-2.2-1.8-1.61.51.21.4-0.80.6-0.3
Pavlov. Cond. intertrial magazine entries1.31.72.71.6-1.5-1.61.6-1.6-1.5-1.31.21.21.00.00.7-0.7
Pavlov. Cond. lever-magazine prob. diff.2.63.37.6-2.82.22.3-2.32.31.91.8-1.5-1.3-1.50.9-0.60.4
Pavlov. Cond. response bias4.46.010.4-3.23.03.0-3.03.02.72.7-2.2-2.1-2.20.7-1.21.1
Time in closed arm before self-admin0.60.72.71.4-0.2-0.50.5-0.5-0.1-0.6-0.5-0.3-0.4-1.6-1.01.2
Time in closed arm after self-admin0.40.54.7-0.10.30.1-0.10.10.40.2-0.3-0.5-0.5-0.2-0.52.2
Time in open arm before self-admin0.70.83.3-1.80.40.5-0.50.50.30.60.50.30.21.80.9-1.2
Time in open arm after self-admin0.40.54.4-1.10.20.3-0.30.30.10.10.20.30.00.40.1-2.1
Bone: periosteal estimation0.91.95.7-2.41.61.6-1.61.61.51.5-0.9-0.8-0.90.7-0.30.3
Bone: periosteal perimeter0.20.31.9-1.40.60.5-0.50.50.60.5-0.10.0-0.20.50.0-0.4
Bone: post-yield work3.34.45.8-2.02.32.4-2.42.42.22.2-2.2-2.0-2.2-0.5-1.62.1
Progressive ratio test 1 active lever presses2.93.04.4-1.11.91.8-1.81.81.61.9-2.0-1.8-2.1-1.1-1.81.6
Progressive ratio test 1 breakpoint2.22.33.3-1.11.71.6-1.61.61.41.7-1.8-1.5-1.8-0.7-1.41.2
Progressive ratio test 1 inactive lever presses4.54.96.6-1.22.32.2-2.22.22.22.1-2.6-2.5-2.5-1.6-2.42.5
Progressive ratio test 2 active lever presses2.12.33.4-0.81.41.4-1.41.41.61.5-1.7-1.3-1.8-1.5-1.81.5
Progressive ratio test 2 breakpoint1.71.93.1-0.71.31.3-1.31.31.41.3-1.6-1.2-1.6-1.5-1.81.4
Progressive ratio test 2 inactive lever presses6.57.511.7-1.22.72.6-2.62.62.82.6-3.2-2.9-3.1-2.0-2.93.4
Incentive Sensitization - Responses0.90.91.3-0.51.01.0-1.01.01.10.7-1.1-0.9-1.0-0.9-1.01.1
Incentive Sensitization - Breakpoint0.70.81.2-0.50.90.9-0.90.91.10.7-1.0-0.7-0.9-0.7-0.91.1
Sum of active levers in priming session hrs 5-60.10.10.3-0.30.30.2-0.20.20.00.0-0.1-0.2-0.00.60.30.4
Progressive ratio0.10.10.30.10.0-0.20.2-0.2-0.00.1-0.2-0.3-0.1-0.6-0.5-0.0
Food seeking constrained by brief footshock0.70.92.9-1.71.11.1-1.11.10.90.9-0.6-0.8-0.80.4-0.50.4
Seeking ratio, punishment vs. effort0.91.01.7-1.11.21.3-1.31.31.10.8-1.0-0.9-0.90.1-0.51.1
Retroperitoneal fat weight1.23.85.11.8-2.2-2.02.0-2.0-2.0-2.02.01.92.30.81.9-2.2
Reaction time number correct0.10.20.5-0.50.70.5-0.50.50.50.6-0.5-0.5-0.10.40.1-0.0
Reaction time mean minus median0.20.20.6-0.4-0.3-0.40.4-0.4-0.5-0.10.60.60.20.80.4-0.6
Reaction time mean minus median AUC0.30.41.9-0.7-0.2-0.20.2-0.2-0.50.10.70.70.31.40.8-0.9
Reaction time num false alarms0.50.71.71.3-1.1-1.11.1-1.1-1.0-0.90.70.70.5-0.40.10.1
Reaction time num false alarms AUC0.91.22.51.6-1.4-1.31.3-1.3-1.3-1.30.91.00.7-0.50.1-0.1
Reaction time trials correct on left0.10.20.5-0.50.70.5-0.50.50.50.6-0.5-0.5-0.10.40.1-0.0
Reaction time trials on left0.10.20.4-0.50.70.5-0.50.50.50.5-0.5-0.5-0.00.40.1-0.1
Reaction time mean0.10.10.6-0.80.30.4-0.40.40.30.3-0.1-0.3-0.4-0.3-0.4-0.0
Reaction time mean AUC0.00.00.3-0.50.10.1-0.10.10.10.00.1-0.1-0.2-0.2-0.3-0.2
Median of all reaction times0.20.20.5-0.60.30.5-0.50.50.50.3-0.3-0.5-0.5-0.7-0.70.2
Reaction time omissions0.20.30.60.1-0.7-0.70.7-0.7-0.5-0.50.80.30.70.10.4-0.3
Reaction time false alarm rate0.81.12.21.5-1.4-1.31.3-1.3-1.2-1.21.01.00.5-0.7-0.1-0.0
Reaction time premature initiation rate0.30.41.40.10.40.3-0.30.30.50.4-0.8-0.5-0.9-1.2-1.20.3
Reaction time premature initiations0.40.51.0-0.10.70.5-0.50.50.70.7-1.0-0.6-0.9-0.9-1.00.4
Std. dev. reaction times0.10.21.0-1.00.30.4-0.40.40.20.40.0-0.1-0.50.3-0.3-0.3
Reaction time trials completed0.10.20.4-0.50.70.5-0.50.50.50.5-0.5-0.5-0.00.40.1-0.1
Reaction time trials AUC0.10.10.5-0.30.30.2-0.20.20.20.2-0.1-0.10.30.70.5-0.4
Run reversals in cocaine runway, females1.11.11.8-1.21.21.4-1.41.41.11.0-0.9-0.9-1.10.3-0.60.3
Run reversals in cocaine runway, males4.44.27.30.9-2.2-2.02.0-2.0-2.2-2.32.42.72.51.52.2-0.9
Latency to leave start box in cocaine runway1.01.12.5-0.51.11.2-1.21.20.91.2-1.1-1.0-1.10.2-0.41.6
Latency to leave start box in cocaine runway, F1.71.95.4-0.61.41.5-1.51.51.31.3-1.5-1.4-1.2-0.2-0.82.3
Latency to leave start box in cocaine runway, M0.50.50.80.4-0.9-0.70.7-0.7-0.7-0.30.90.90.30.50.5-0.8
Std. dev. time between licks in bursts2.22.65.7-0.51.51.1-1.11.11.71.4-1.8-2.0-1.9-2.2-2.41.4
Total sessions with >9 infusions0.20.32.00.40.0-0.20.2-0.20.1-0.3-0.4-0.3-0.1-1.4-0.80.3
Short access day 1 total inactive lever presses4.55.08.2-0.72.42.3-2.32.32.22.0-2.9-2.5-2.5-1.4-2.22.4
Short access day 10 total inactive lever presses1.31.41.9-1.11.41.4-1.41.41.21.3-1.2-1.1-1.20.3-0.61.4
Short access day 1 total infusions1.41.52.2-0.81.31.2-1.21.21.30.5-1.5-1.3-1.1-1.3-1.41.3
Short access day 10 total infusions0.20.21.20.30.2-0.10.1-0.10.10.1-0.5-0.5-0.4-1.1-0.80.3
Short access total infusions0.20.21.50.20.20.1-0.10.10.2-0.2-0.5-0.4-0.3-1.2-0.80.3
Short access day 1 locomotion0.10.10.30.20.20.1-0.10.10.20.3-0.4-0.4-0.3-0.5-0.40.3
Short access day 10 total locomotion1.61.83.3-0.91.41.0-1.01.01.41.5-1.5-1.6-1.7-1.4-1.80.8
Short access total locomotion0.30.32.00.70.1-0.20.2-0.20.1-0.0-0.5-0.6-0.3-1.4-0.90.2
One hour access (0.3 mA shock)5.05.98.6-2.02.62.4-2.42.42.62.0-2.7-2.5-2.8-2.1-2.91.8
Compulsive drug intake0.30.30.8-0.50.60.8-0.80.80.5-0.1-0.6-0.3-0.20.1-0.20.9
One hour access (shock baseline)1.82.14.6-0.71.41.1-1.11.11.51.3-1.7-1.6-1.8-1.9-2.10.8
Social response proportion0.50.50.9-1.00.80.9-0.90.90.71.0-0.4-0.3-0.60.90.20.4
Social responses0.10.10.4-0.20.40.4-0.40.40.20.2-0.20.2-0.00.70.40.3
Social time4.05.37.9-2.62.82.8-2.82.82.62.4-2.3-2.2-2.1-0.0-1.41.6
Soleus weight0.10.40.70.6-0.5-0.40.4-0.4-0.6-0.80.50.70.80.50.9-0.6
Bone: stiffness1.21.93.2-1.71.71.6-1.61.61.61.8-1.2-1.1-1.10.7-0.30.9
Tibialis anterior weight0.92.96.00.5-1.5-1.21.2-1.2-1.8-1.31.82.02.02.22.4-2.0
Time to tail flick, vehicle, before self-admin0.20.20.70.60.20.2-0.20.20.2-0.2-0.6-0.3-0.2-0.8-0.4-0.9
Time to tail flick, vehicle, after self-admin0.60.71.60.6-0.8-1.31.3-1.3-0.8-0.80.70.20.5-0.7-0.1-0.3
Time to tail flick, test, before self-admin5.04.86.7-0.92.22.1-2.12.12.32.2-2.6-2.5-2.4-1.9-2.42.5
Time to tail flick, test, after self-admin0.40.40.7-0.40.80.5-0.50.50.60.6-0.8-0.8-0.6-0.6-0.6-0.1
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.2-0.5-0.80.8-0.8-0.5-0.30.60.10.1-0.3-0.20.8
Delta time to tail flick, test, before/after SA3.53.24.11.1-1.8-1.91.9-1.9-1.9-2.02.01.92.00.91.7-2.0
Tibia length2.26.114.8-3.82.93.1-3.13.12.52.9-1.9-1.9-1.81.5-0.50.9
Ambulatory time before self-admin0.10.10.20.4-0.4-0.50.5-0.5-0.3-0.40.40.30.20.10.20.1
Ambulatory time after self-admin3.03.37.5-2.72.22.0-2.02.01.91.9-1.4-1.8-1.90.7-1.01.0
Bone: tissue strength2.42.33.7-1.91.81.7-1.71.71.51.6-1.4-1.2-1.80.3-1.01.5
Total heroin consumption0.50.60.9-0.50.80.8-0.80.80.60.9-0.9-0.9-0.9-0.3-0.70.8
Bone: trabecular number1.32.13.9-1.81.52.0-2.02.01.41.9-1.1-1.1-0.91.0-0.1-0.2
Bone: trabecular spacing1.41.83.10.6-1.4-1.61.6-1.6-1.6-1.81.61.61.10.30.8-1.0
Bone: trabecular thickness0.50.61.4-0.60.81.2-1.21.20.70.9-0.8-0.5-0.30.50.10.2
Bone: trabecular tissue density4.36.19.91.9-2.5-2.72.7-2.7-2.6-3.12.52.92.70.92.1-2.2
Water consumed over 24 hours1.01.12.0-1.31.41.4-1.41.41.00.7-1.1-1.3-0.70.4-0.3-0.2
Number of responses in last shaping day3.73.96.9-0.92.01.6-1.61.62.01.2-2.4-2.1-2.1-2.2-2.42.6