Hub : Genes

Sarm1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Sarm1 0.4 0.19 0.0e+00 0.3 0.33 0.32 0.32 2.4e-34 3.6e-37 6.6e-37 7.0e-37
2 pVTA gene expression Sarm1 0.04 0.03 1.8e-03 0.01 0.02 0.01 0.01 2.3e-02 5.2e-03 2.5e-02 2.5e-02
3 PL mRNA stability Sarm1 0.03 0.04 5.8e-03 0.03 0.01 0.03 0.03 1.2e-04 8.4e-03 1.1e-04 2.1e-04
4 Adipose gene expression Sarm1 0.19 0.17 4.6e-05 0.02 0.03 0.03 0.03 1.4e-03 4.3e-04 9.8e-05 8.5e-04
5 Adipose mRNA stability Sarm1 0.05 0.1 9.2e-03 0.01 0 0.01 0 4.0e-02 7.5e-02 6.4e-02 1.1e-01
6 BLA gene expression Sarm1 0.12 0.11 4.1e-04 0.05 0.05 0.06 0.05 1.6e-03 7.7e-04 3.3e-04 7.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density1.83.23.8-1.9-2.0-1.91.7-1.91.3
Area under the delay curve0.71.12.11.11.30.2-1.40.9-0.8
BMI with tail1.75.86.6-2.6-2.6-2.52.2-2.52.1
BMI without tail1.05.16.4-2.5-2.5-2.42.2-2.21.6
Body weight2.611.212.7-3.6-3.5-3.53.2-3.32.9
Weight adjusted by age0.10.20.7-0.3-0.3-0.90.2-0.1-0.5
Bone surface1.22.43.0-1.7-1.7-1.71.3-1.71.2
Bone volume1.22.33.0-1.6-1.6-1.71.3-1.61.1
Breakpoint value in progressive ratio session0.10.20.4-0.5-0.70.10.3-0.40.0
Number of licking bursts0.20.61.40.70.71.2-0.70.7-0.3
Context. condit. distance diff. score0.50.61.0-0.9-0.8-1.00.7-0.80.5
Locomotion velocity, session 11.82.12.5-1.6-1.6-1.21.4-1.41.3
Locomotion distance, session 10.20.20.4-0.5-0.60.20.6-0.30.5
Locomotion velocity, session 20.00.00.0-0.1-0.20.10.20.00.2
Locomotion distance, session 21.11.52.1-1.2-1.3-0.81.2-1.31.4
Locomotion velocity, session 34.14.76.92.12.02.1-2.61.9-2.2
Locomotion distance, session 30.50.61.20.70.70.7-1.10.6-0.9
Stereotopy head waving bouts, day 30.00.00.1-0.0-0.1-0.2-0.2-0.1-0.3
Stereotopy head waving duration, day 30.81.01.71.00.80.9-1.00.9-1.3
Locomotion velocity, session 70.20.20.5-0.4-0.5-0.70.0-0.3-0.6
Locomotion distance, session 70.20.30.5-0.7-0.7-0.70.5-0.5-0.1
Stereotopy head waving bouts, day 70.50.50.9-0.7-0.8-0.90.5-0.80.4
Stereotopy head waving duration, day 70.10.20.3-0.4-0.5-0.60.2-0.5-0.1
Locomotion velocity, session 80.00.00.1-0.2-0.2-0.1-0.1-0.40.2
Locomotion distance, session 80.71.01.2-1.0-1.1-0.90.9-1.00.9
Degree of sensitization distance3.03.24.3-1.8-1.8-1.92.1-1.61.5
Degree of sensitization stereotypy0.50.50.7-0.8-0.8-0.80.7-0.80.5
Conditioned locomotion2.02.33.31.61.51.8-1.61.4-1.2
Cocaine response after cond. corrected1.42.12.9-1.4-1.4-1.21.6-1.51.7
Cocaine response after cond. not corrected1.92.83.8-1.6-1.6-1.41.7-1.72.0
Cocaine response before conditioning0.10.10.2-0.5-0.5-0.30.2-0.40.1
Saline control response0.00.10.20.10.10.2-0.30.0-0.5
Bone: connectivity density3.04.86.1-2.4-2.5-2.22.0-2.31.6
Bone: cortical apparent density0.40.60.70.90.90.8-0.70.9-0.7
Bone: cortical area1.22.03.11.51.51.1-1.71.4-1.3
Bone: cortical porosity0.20.20.4-0.6-0.5-0.60.4-0.4-0.1
Bone: cortical porosity0.10.10.2-0.4-0.3-0.40.2-0.3-0.3
Bone: cortical thickness2.84.75.82.22.21.7-2.42.2-2.2
Bone: cortical thickness0.10.10.30.20.20.5-0.30.4-0.6
Bone: cortical tissue density0.20.40.40.70.70.6-0.50.7-0.5
Condit. Reinf. active minus inactive responses1.01.11.91.00.90.9-1.30.9-1.4
Condit. Reinf. active-inactive response ratio0.40.41.00.40.40.3-0.80.4-1.0
Condit. Reinf. active responses0.00.10.20.20.10.2-0.40.1-0.2
Condit. Reinf. inactive responses0.40.51.3-0.5-0.6-0.30.8-0.61.1
Incentive salience index mean0.40.51.10.60.60.4-1.10.5-1.0
Condit. Reinf. lever presses0.10.20.7-0.3-0.4-0.8-0.2-0.4-0.0
Condit. Reinf. active minus inactive responses0.71.01.90.90.81.4-0.71.0-1.1
Condit. Reinf. active-inactive response ratio0.60.91.80.90.91.3-0.61.0-0.7
Condit. Reinf. active responses0.50.71.40.70.61.0-0.60.8-1.2
Condit. Reinf. inactive responses0.10.10.5-0.1-0.1-0.3-0.20.0-0.7
Condit. Reinf. lever presses2.63.85.02.01.92.2-1.81.9-1.8
Condit. Reinf. lever reinforcers received0.81.11.60.90.91.2-0.91.0-1.3
Conditioned reinforcement - actives0.10.40.5-0.7-0.7-0.50.5-0.70.6
Conditioned reinforcement - inactives0.20.41.4-0.5-0.5-0.30.5-0.61.2
Conditioned locomotion0.60.91.8-0.8-0.8-1.10.5-0.91.4
Patch foraging indifference point 0 sec0.41.21.90.90.91.0-1.11.0-1.4
Patch foraging indifference point AUC1.33.04.71.91.82.2-1.71.5-1.2
Delay disc. indifference point, 0s delay0.70.81.00.80.90.9-1.00.9-0.9
Delay disc. indifference point, 16s delay0.30.50.90.81.0-0.2-0.90.6-0.2
Delay disc. indifference point, 2s delay2.22.42.91.61.71.3-1.61.6-1.5
Delay disc. indifference point, 24s delay0.60.91.9-0.9-0.9-1.40.7-1.10.6
Delay disc. indifference point, 4s delay0.10.10.30.30.4-0.2-0.50.4-0.0
Delay disc. indifference point, 8s delay0.40.61.40.90.90.0-1.20.4-0.7
Indifference point function ln k0.30.81.6-1.0-0.9-1.31.0-0.60.5
Indifference point function log k0.30.81.6-1.0-0.9-1.31.0-0.60.5
Patch foraging total patch changes 0 sec0.31.01.90.80.80.9-1.01.0-1.4
Patch foraging total patch changes 12 sec0.20.30.80.50.50.9-0.50.4-0.3
Patch foraging total patch changes 18 sec1.33.04.21.71.62.1-1.61.8-1.6
Patch foraging total patch changes 24 sec1.13.85.01.91.82.2-1.81.9-2.0
Patch foraging total patch changes 6 sec2.84.85.72.32.32.4-2.32.0-1.9
Patch foraging time to switch 0 sec0.72.72.9-1.7-1.6-1.71.5-1.71.7
Patch foraging water rate 0 sec0.93.34.41.81.82.1-1.61.9-1.8
Patch foraging water rate 12 sec0.10.20.6-0.5-0.5-0.50.8-0.1-0.1
Patch foraging water rate 18 sec0.41.01.9-0.9-0.8-1.31.4-0.60.7
Patch foraging water rate 24 sec0.10.20.30.40.40.5-0.40.5-0.3
Patch foraging water rate 6 sec1.11.62.11.21.31.2-1.01.5-1.3
Seeking ratio, delayed vs. immediate footshock1.31.92.41.41.51.3-1.51.3-0.9
Distance traveled before self-admin1.94.24.92.22.21.4-2.12.2-2.1
Distance traveled after self-admin0.00.10.10.30.3-0.2-0.30.3-0.3
Extensor digitorum longus weight0.83.24.7-1.8-1.8-2.21.6-1.81.3
Bone: elastic displacement2.73.43.91.91.91.7-2.01.8-1.7
Bone: elastic work9.111.914.73.43.43.1-3.83.4-3.5
Bone: endosteal estimation0.00.00.0-0.0-0.10.2-0.0-0.10.2
Bone: endosteal perimeter0.00.10.5-0.2-0.2-0.10.2-0.40.7
Epididymis fat weight5.929.933.8-5.5-5.4-5.65.8-5.25.3
Delta time in closed arm before/after self-admin2.42.23.31.71.70.9-1.21.8-1.4
Delta time in open arm before/after self-admin4.55.37.7-2.6-2.6-1.21.9-2.82.4
Diff in mean of infusions in LGA sessions0.30.50.7-0.8-0.8-0.30.6-0.80.8
Delay discount exponential model param0.60.81.4-0.9-1.1-0.11.2-0.70.7
Extinction: sum of active levers before priming0.40.61.0-0.9-1.0-0.50.5-0.90.5
Active lever presses in extinction session 60.20.20.7-0.3-0.4-0.50.3-0.1-0.8
Bone: final force0.50.81.90.70.70.4-1.40.6-1.2
Bone: final moment0.50.82.00.70.70.4-1.40.7-1.2
Food consumed during 24 hour testing period0.30.62.20.50.60.2-0.40.9-1.5
Glucose1.11.82.31.51.51.3-1.21.2-1.3
Heart weight1.01.62.4-1.5-1.5-1.31.2-1.30.7
Delay discount hyperbolic model param1.01.22.1-1.2-1.3-0.31.5-1.01.1
Intermittent access intake day 1-15 change0.00.10.2-0.2-0.20.00.50.1-0.1
Intermittent access intake escalation0.00.10.3-0.4-0.4-0.00.5-0.10.1
Intermittent access intake escalation 20.10.10.20.40.40.4-0.20.4-0.3
Intermitt. access day 1 inactive lever presses0.00.10.30.40.40.5-0.50.3-0.2
Intermitt. access day 15 inactive lever presses0.20.93.20.80.81.8-0.40.9-0.1
Intermitt. access escalation Index0.51.72.7-1.3-1.1-1.61.5-1.01.1
Intermittent access day 1 total infusions0.20.51.4-0.5-0.5-0.30.3-0.91.2
Intermittent access day 15 total infusions0.61.42.2-1.2-1.2-0.61.0-1.31.5
Intermittent access terminal intake (last 3 days)1.01.72.9-1.3-1.3-1.01.2-1.31.7
Intermittent access total infusions0.50.61.4-0.7-0.7-0.40.5-0.91.2
Intermittent access day 1 locomotion0.10.20.5-0.2-0.2-0.2-0.2-0.60.7
Intermittent access day 15 total locomotion0.20.60.9-0.7-0.8-0.80.5-0.91.0
Intermittent access total locomotion0.60.81.1-0.8-0.9-0.70.5-1.11.1
Intermittent access standard deviation0.00.10.3-0.1-0.10.40.2-0.30.6
Left kidney weight0.00.20.3-0.5-0.5-0.50.3-0.40.2
Right kidney weight0.10.81.0-0.9-0.9-1.00.8-0.90.7
Cocaine induced anxiety0.10.30.80.40.40.9-0.40.5-0.3
Post-drug Anxiety0.10.10.3-0.4-0.40.00.5-0.10.0
Baseline Anxiety0.10.20.5-0.5-0.5-0.60.7-0.2-0.0
Tail length0.31.62.1-1.4-1.3-1.31.5-1.20.8
Length with tail0.62.73.6-1.8-1.6-1.71.9-1.51.4
Length without tail0.31.72.3-1.3-1.2-1.41.5-1.01.5
Times rat made contact with spout0.20.21.00.30.2-0.2-0.30.4-1.0
Lifetime Intake0.81.02.5-0.9-0.9-0.50.7-1.21.6
Liver weight, left5.29.010.2-3.0-3.0-3.13.2-2.92.9
Liver weight, right3.96.87.2-2.6-2.7-2.72.6-2.62.4
Locomotor activity0.00.10.20.10.20.40.20.3-0.2
Locomotor testing distance0.00.10.20.30.30.40.20.3-0.1
Locomotor testing rearing0.10.20.60.30.30.80.10.4-0.3
Locomotion in novel chamber1.52.03.11.71.80.5-1.31.6-1.0
Locomotion in novel chamber post-restriction0.00.10.5-0.1-0.0-0.7-0.2-0.0-0.0
Fecal boli incidents, locomotor time 10.61.72.1-1.4-1.4-1.21.4-1.31.1
Change in fecal boli incidents, locomotor task0.10.10.20.20.3-0.2-0.5-0.00.4
Time >=10cm from walls, locomotor time 10.10.10.4-0.2-0.2-0.1-0.4-0.1-0.6
Bouts of movement, locomotor time 10.40.50.60.70.70.5-0.70.7-0.7
Total resting periods, locomotor time 10.10.20.30.40.40.3-0.40.4-0.5
Rest time, locomotor task time 10.00.10.1-0.3-0.40.20.1-0.20.1
Distance moved, locomotor task time 10.10.20.30.50.60.3-0.60.5-0.1
Vertical activity count, locomotor time 10.00.10.20.10.2-0.0-0.4-0.10.2
Time >=10cm from walls, locomotor time 20.30.81.4-1.2-1.1-0.80.1-1.20.3
Bouts of movement, locomotor time 20.10.50.70.70.70.6-0.60.8-0.6
Total resting periods, locomotor time 20.00.20.30.40.40.4-0.40.6-0.5
Rest time, locomotor task time 20.20.30.80.40.20.8-0.10.4-0.9
Distance moved, locomotor task time 20.10.10.20.30.4-0.0-0.40.10.5
Vertical activity count, locomotor time 20.10.31.10.20.4-0.1-0.5-0.11.0
Light reinforcement 10.00.00.00.10.1-0.1-0.00.00.0
Light reinforcement 20.20.40.50.70.70.5-0.70.7-0.5
Bone: marrow area0.00.00.0-0.0-0.00.2-0.0-0.10.2
Bone: maximum diameter0.30.51.10.70.70.5-1.00.7-0.5
Bone: maximum force0.51.01.90.90.90.6-1.40.9-1.1
Bone: maximum moment0.61.12.00.91.00.6-1.40.9-1.2
Mean time between licks in bursts0.21.21.7-1.0-1.0-1.31.0-1.01.3
Mean num. licks in bursts0.20.62.2-0.7-0.6-1.50.7-0.6-0.2
Cd content in liver0.70.82.00.90.91.4-0.70.70.2
Co content in liver0.50.61.60.60.71.3-0.80.5-0.7
Cu content in liver1.92.22.61.51.41.6-1.41.5-1.5
Fe content in liver1.92.33.9-1.6-1.7-0.91.2-2.01.7
K content in liver0.10.10.2-0.4-0.3-0.40.3-0.30.2
Mg content in liver0.91.01.80.90.81.4-1.30.8-0.9
Mn content in liver0.20.30.40.50.50.6-0.40.6-0.4
Na content in liver0.40.41.2-0.4-0.3-0.20.5-0.71.1
Rb content in liver0.10.10.1-0.4-0.30.30.1-0.20.1
Se content in liver1.21.43.51.00.81.9-1.50.7-0.8
Sr content in liver0.50.40.9-0.7-0.6-0.61.0-0.40.2
Zn content in liver0.30.30.7-0.6-0.70.00.2-0.80.5
Bone: minimum diameter0.00.10.10.40.30.2-0.30.20.2
Time in familiar zone, hab. session 10.20.20.30.50.60.2-0.40.4-0.4
Time in novel zone, hab. session 10.10.10.1-0.3-0.4-0.10.4-0.20.2
Total zone transitions, hab. session 10.00.00.10.10.20.2-0.00.00.3
Total locomotion distance, hab. session 10.10.10.30.30.40.3-0.10.5-0.2
Locomotion velocity, hab. session 10.30.40.60.60.70.7-0.50.8-0.4
Time in familiar zone, hab. session 20.30.30.50.50.50.7-0.40.6-0.7
Time in novel zone, hab. session 20.10.10.20.30.30.0-0.50.20.0
Total zone transitions, hab. session 20.40.50.9-0.6-0.6-0.50.7-0.71.0
Total locomotion distance, hab. session 20.10.10.50.40.30.7-0.00.4-0.0
Locomotion velocity, hab. session 20.10.20.50.40.40.7-0.00.40.0
Novel to familiar place preference ratio0.70.91.1-1.0-1.0-1.10.9-1.00.8
Novelty place preference0.91.21.5-1.1-1.1-1.21.0-1.10.9
Time in novel zone, NPP test1.01.21.5-1.2-1.2-1.21.1-1.10.9
Total zone transitions, NPP test0.00.10.2-0.1-0.10.30.2-0.10.4
Total locomotion distance, NPP test1.01.32.71.21.11.6-0.81.3-0.6
Locomotion velocity, NPP test1.11.53.01.31.21.7-0.91.4-0.7
Intraocular pressure0.81.41.71.31.31.1-1.11.2-0.9
Delta distance traveled before/after self-admin2.62.93.4-1.8-1.8-1.51.6-1.81.6
Delta ambulatory time before/after self-admin1.42.43.0-1.7-1.7-0.81.4-1.71.7
Parametrial fat weight6.014.217.3-3.8-3.8-3.74.2-3.63.3
Pavlov. Cond. lever latency0.00.00.2-0.1-0.10.10.4-0.10.2
Pavlov. Cond. magazine entry latency0.00.00.1-0.1-0.2-0.10.0-0.10.3
Pavlov. Cond. change in total contacts0.30.30.60.60.60.5-0.80.5-0.4
Pavlov. Cond. index score0.00.00.10.10.10.0-0.40.10.0
Pavlov. Cond. latency score0.00.00.10.0-0.0-0.1-0.30.00.1
Pavlov. Cond. lever contacts0.00.00.1-0.00.0-0.3-0.3-0.10.1
Pavlov. Cond. magazine entry number0.10.10.2-0.4-0.4-0.40.5-0.40.1
Pavlov. Cond. intertrial magazine entries0.30.40.80.60.50.9-0.50.5-0.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.30.20.2-0.50.2-0.0
Pavlov. Cond. response bias0.00.00.10.10.0-0.0-0.3-0.10.2
Pavlov. Cond. lever latency2.53.55.0-1.9-1.9-2.21.5-1.91.6
Pavlov. Cond. magazine entry latency0.20.20.40.50.50.6-0.50.5-0.4
Pavlov. Cond. change in total contacts1.02.43.51.51.51.9-1.41.5-1.4
Pavlov. Cond. index score2.03.24.61.81.82.1-1.61.8-1.5
Pavlov. Cond. latency score2.33.75.12.01.92.3-1.71.9-1.7
Pavlov. Cond. lever contacts1.52.33.41.51.41.8-1.21.5-1.5
Pavlov. Cond. magazine entry number0.00.00.2-0.1-0.1-0.50.1-0.10.1
Pavlov. Cond. intertrial magazine entries0.30.60.8-0.8-0.8-0.90.9-0.70.8
Pavlov. Cond. lever-magazine prob. diff.1.62.43.71.61.51.9-1.41.5-1.3
Pavlov. Cond. response bias1.21.62.61.31.31.6-1.01.4-1.0
Time in closed arm before self-admin1.32.23.2-1.5-1.4-1.21.3-1.61.8
Time in closed arm after self-admin0.30.30.70.70.8-0.5-0.00.60.4
Time in open arm before self-admin2.12.64.21.61.51.2-1.31.8-2.1
Time in open arm after self-admin0.60.61.1-1.0-1.1-0.10.6-1.00.5
Bone: periosteal estimation0.30.61.10.80.80.7-1.00.7-0.6
Bone: periosteal perimeter0.10.30.60.60.60.2-0.80.4-0.1
Bone: post-yield work0.40.61.3-0.7-0.6-1.10.5-0.80.8
Progressive ratio test 1 active lever presses0.30.51.00.60.71.0-0.80.6-0.2
Progressive ratio test 1 breakpoint0.30.61.30.70.71.1-0.80.7-0.2
Progressive ratio test 1 inactive lever presses0.61.52.11.31.31.4-1.51.2-0.4
Progressive ratio test 2 active lever presses0.30.40.70.60.60.8-0.70.6-0.4
Progressive ratio test 2 breakpoint0.30.40.70.60.60.9-0.70.6-0.4
Progressive ratio test 2 inactive lever presses0.00.10.10.30.30.4-0.10.30.1
Incentive Sensitization - Responses0.00.00.00.1-0.10.0-0.2-0.0-0.1
Incentive Sensitization - Breakpoint0.00.00.00.0-0.10.0-0.1-0.1-0.1
Sum of active levers in priming session hrs 5-60.90.81.5-1.1-1.2-0.60.7-1.10.5
Progressive ratio0.10.31.4-0.0-0.10.3-0.30.2-1.2
Food seeking constrained by brief footshock0.10.10.2-0.3-0.30.10.4-0.30.4
Seeking ratio, punishment vs. effort0.10.21.30.10.2-0.20.3-0.11.1
Retroperitoneal fat weight0.83.45.4-1.7-1.6-1.82.3-1.42.2
Reaction time number correct0.31.21.6-1.2-1.2-0.91.3-1.01.0
Reaction time mean minus median0.10.40.8-0.5-0.5-0.20.8-0.50.9
Reaction time mean minus median AUC0.43.05.0-1.5-1.5-1.31.9-1.72.2
Reaction time num false alarms4.88.18.52.92.92.6-2.92.9-2.9
Reaction time num false alarms AUC3.78.59.32.92.92.6-3.03.0-3.0
Reaction time trials correct on left0.31.21.6-1.2-1.2-0.91.3-1.01.0
Reaction time trials on left0.41.31.7-1.2-1.2-1.01.3-1.01.0
Reaction time mean0.51.11.8-0.9-1.0-0.51.2-1.01.4
Reaction time mean AUC0.40.91.7-0.8-0.9-0.51.1-0.91.3
Median of all reaction times0.50.71.4-0.8-0.8-0.21.0-0.81.2
Reaction time omissions1.32.13.3-1.4-1.4-1.81.4-1.41.3
Reaction time false alarm rate6.28.69.82.93.02.6-3.12.9-3.0
Reaction time premature initiation rate0.20.40.7-0.6-0.5-0.80.5-0.60.6
Reaction time premature initiations0.20.71.1-0.9-0.8-1.00.8-0.70.8
Std. dev. reaction times0.41.31.7-1.1-1.1-0.91.3-1.11.3
Reaction time trials completed0.41.31.7-1.2-1.2-1.01.3-1.01.0
Reaction time trials AUC0.30.91.3-1.1-1.0-0.81.2-0.80.8
Run reversals in cocaine runway, females0.30.30.9-0.3-0.3-0.70.9-0.20.6
Run reversals in cocaine runway, males0.30.30.8-0.3-0.3-0.90.4-0.40.8
Latency to leave start box in cocaine runway1.31.86.70.90.80.8-0.71.2-2.6
Latency to leave start box in cocaine runway, F0.50.62.70.40.30.4-0.20.7-1.7
Latency to leave start box in cocaine runway, M0.70.72.90.60.50.1-0.30.8-1.7
Std. dev. time between licks in bursts0.10.20.5-0.2-0.2-0.70.3-0.30.5
Total sessions with >9 infusions0.81.02.9-0.8-0.7-0.80.5-1.01.7
Short access day 1 total inactive lever presses2.75.37.0-2.3-2.2-2.22.0-2.42.6
Short access day 10 total inactive lever presses0.00.00.10.00.00.3-0.2-0.10.2
Short access day 1 total infusions0.81.54.7-1.0-1.0-0.40.7-1.32.2
Short access day 10 total infusions0.50.92.4-0.7-0.7-0.60.6-1.01.5
Short access total infusions0.50.72.9-0.6-0.5-0.30.4-0.91.7
Short access day 1 locomotion0.10.10.7-0.00.00.3-0.2-0.10.8
Short access day 10 total locomotion0.20.92.20.80.81.5-1.10.8-0.7
Short access total locomotion0.30.41.00.60.60.8-1.00.40.0
One hour access (0.3 mA shock)0.10.10.30.20.20.5-0.30.00.0
Compulsive drug intake0.71.01.5-1.1-1.1-0.91.0-1.20.9
One hour access (shock baseline)0.10.10.30.40.40.5-0.40.4-0.1
Social response proportion2.32.93.7-1.8-1.7-1.71.4-1.91.6
Social responses1.82.42.8-1.7-1.6-1.31.5-1.71.5
Social time1.62.63.5-1.5-1.5-1.61.3-1.91.7
Soleus weight2.36.67.9-2.6-2.6-2.82.3-2.72.3
Bone: stiffness1.62.93.4-1.9-1.8-1.71.7-1.71.5
Tibialis anterior weight2.69.110.4-3.1-3.1-3.22.9-3.22.4
Time to tail flick, vehicle, before self-admin0.20.30.9-0.4-0.3-0.90.2-0.50.6
Time to tail flick, vehicle, after self-admin0.20.40.90.60.70.9-0.70.5-0.0
Time to tail flick, test, before self-admin0.00.10.2-0.1-0.1-0.40.3-0.00.2
Time to tail flick, test, after self-admin1.01.13.20.80.80.7-0.41.2-1.8
Delta time to tail flick, vehicle, before/after SA0.80.82.10.80.71.4-0.70.8-0.9
Delta time to tail flick, test, before/after SA0.60.81.40.80.71.2-0.70.9-1.0
Tibia length0.00.00.10.20.2-0.2-0.30.2-0.0
Ambulatory time before self-admin0.51.42.11.41.50.2-1.41.2-1.0
Ambulatory time after self-admin0.00.00.2-0.1-0.1-0.5-0.0-0.10.0
Bone: tissue strength1.61.73.01.31.30.8-1.71.3-1.3
Total heroin consumption1.82.13.5-1.7-1.9-1.41.4-1.50.5
Bone: trabecular number2.24.15.0-2.2-2.2-2.02.0-2.11.5
Bone: trabecular spacing0.20.30.60.50.60.3-0.80.5-0.5
Bone: trabecular thickness0.00.00.00.00.0-0.0-0.1-0.0-0.1
Bone: trabecular tissue density1.01.82.61.41.41.6-1.21.3-0.9
Water consumed over 24 hours0.00.10.20.20.20.3-0.20.3-0.5
Number of responses in last shaping day0.81.11.71.11.11.2-1.30.9-0.3