Hub : Genes

Sarm1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Sarm1	0.4	0.19	0.0e+00	0.3	0.33	0.32	0.32	2.4e-34	3.6e-37	7.0e-37	6.5e-37
2	pVTA	gene expression	Sarm1	0.04	0.03	1.8e-03	0.01	0.02	0.01	0.01	2.3e-02	5.2e-03	2.4e-02	2.5e-02
3	PL	mRNA stability	Sarm1	0.03	0.04	5.8e-03	0.03	0.01	0.03	0.03	1.2e-04	8.4e-03	1.1e-04	2.1e-04
4	Adipose	mRNA stability	Sarm1	0.05	0.1	9.2e-03	0.01	0	0.01	0	4.0e-02	7.5e-02	6.4e-02	1.0e-01
5	Adipose	gene expression	Sarm1	0.19	0.17	4.6e-05	0.02	0.03	0.03	0.02	1.4e-03	4.3e-04	9.8e-05	8.7e-04
6	BLA	gene expression	Sarm1	0.12	0.11	4.1e-04	0.05	0.05	0.06	0.05	1.6e-03	7.7e-04	3.3e-04	7.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	1.9	3.2	3.8	-1.9	-2.0	1.9	1.9	-1.6	-1.2
Area under the delay curve	1.0	1.1	2.2	1.1	1.3	-0.2	-0.9	1.5	0.9
BMI with tail	1.7	5.8	6.6	-2.6	-2.6	2.5	2.5	-2.1	-2.1
BMI without tail	1.7	5.1	6.4	-2.5	-2.5	2.4	2.2	-2.2	-1.6
Body weight	2.5	11.1	12.7	-3.6	-3.5	3.5	3.3	-3.2	-2.9
Weight adjusted by age	0.1	0.2	0.7	-0.3	-0.3	0.9	0.1	-0.2	0.5
Bone surface	1.3	2.4	3.0	-1.7	-1.7	1.7	1.7	-1.2	-1.1
Bone volume	1.3	2.3	3.0	-1.6	-1.6	1.7	1.6	-1.2	-1.1
Breakpoint value in progressive ratio session	0.1	0.2	0.4	-0.5	-0.7	-0.1	0.4	-0.3	-0.0
Number of licking bursts	0.3	0.6	1.4	0.7	0.7	-1.2	-0.7	0.7	0.2
Context. condit. distance diff. score	0.5	0.6	1.0	-0.9	-0.8	1.0	0.8	-0.7	-0.5
Locomotion velocity, session 1	1.9	2.0	2.5	-1.6	-1.6	1.2	1.4	-1.4	-1.4
Locomotion distance, session 1	0.2	0.2	0.5	-0.5	-0.6	-0.2	0.3	-0.7	-0.5
Locomotion velocity, session 2	0.0	0.0	0.1	-0.1	-0.2	-0.1	-0.0	-0.3	-0.2
Locomotion distance, session 2	1.1	1.5	2.0	-1.2	-1.3	0.8	1.3	-1.2	-1.4
Locomotion velocity, session 3	4.1	4.7	7.0	2.1	2.0	-2.1	-1.9	2.7	2.2
Locomotion distance, session 3	0.6	0.6	1.3	0.7	0.7	-0.7	-0.6	1.2	0.9
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.0	-0.1	0.2	0.1	0.2	0.3
Stereotopy head waving duration, day 3	0.8	1.0	1.7	1.0	0.8	-0.9	-0.9	1.0	1.3
Locomotion velocity, session 7	0.2	0.2	0.5	-0.4	-0.5	0.7	0.3	-0.0	0.6
Locomotion distance, session 7	0.3	0.3	0.5	-0.7	-0.7	0.7	0.5	-0.5	0.1
Stereotopy head waving bouts, day 7	0.5	0.5	0.9	-0.7	-0.8	0.9	0.8	-0.5	-0.4
Stereotopy head waving duration, day 7	0.1	0.2	0.3	-0.4	-0.5	0.6	0.5	-0.2	0.1
Locomotion velocity, session 8	0.0	0.0	0.1	-0.2	-0.2	0.1	0.4	0.1	-0.2
Locomotion distance, session 8	0.7	0.9	1.2	-1.0	-1.1	0.9	1.0	-0.9	-0.9
Degree of sensitization distance	3.1	3.2	4.4	-1.8	-1.8	1.9	1.6	-2.1	-1.5
Degree of sensitization stereotypy	0.5	0.5	0.7	-0.8	-0.8	0.8	0.8	-0.7	-0.5
Conditioned locomotion	2.0	2.3	3.3	1.6	1.5	-1.8	-1.4	1.5	1.2
Cocaine response after cond. corrected	1.8	2.1	2.9	-1.4	-1.4	1.2	1.5	-1.6	-1.7
Cocaine response after cond. not corrected	2.4	2.8	3.8	-1.6	-1.6	1.4	1.7	-1.7	-1.9
Cocaine response before conditioning	0.1	0.1	0.2	-0.5	-0.5	0.3	0.4	-0.2	-0.1
Saline control response	0.0	0.1	0.2	0.1	0.1	-0.2	-0.0	0.2	0.5
Bone: connectivity density	3.0	4.7	6.1	-2.4	-2.5	2.2	2.3	-1.9	-1.6
Bone: cortical apparent density	0.5	0.6	0.7	0.9	0.9	-0.8	-0.9	0.7	0.6
Bone: cortical area	1.3	2.0	3.2	1.5	1.5	-1.1	-1.4	1.8	1.3
Bone: cortical porosity	0.2	0.2	0.4	-0.6	-0.5	0.6	0.4	-0.4	0.2
Bone: cortical porosity	0.1	0.1	0.2	-0.4	-0.3	0.4	0.3	-0.2	0.3
Bone: cortical thickness	2.8	4.7	5.9	2.2	2.2	-1.7	-2.2	2.4	2.2
Bone: cortical thickness	0.1	0.1	0.3	0.2	0.2	-0.5	-0.4	0.3	0.6
Bone: cortical tissue density	0.3	0.4	0.4	0.7	0.7	-0.6	-0.7	0.5	0.4
Condit. Reinf. active minus inactive responses	1.0	1.2	1.9	1.0	0.9	-0.9	-0.9	1.3	1.4
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.1	0.4	0.4	-0.3	-0.4	0.9	1.0
Condit. Reinf. active responses	0.1	0.1	0.2	0.2	0.1	-0.2	-0.1	0.5	0.2
Condit. Reinf. inactive responses	0.4	0.5	1.4	-0.5	-0.6	0.3	0.6	-0.8	-1.2
Incentive salience index mean	0.5	0.6	1.2	0.6	0.6	-0.4	-0.5	1.1	1.0
Condit. Reinf. lever presses	0.1	0.2	0.7	-0.3	-0.4	0.8	0.4	0.2	0.0
Condit. Reinf. active minus inactive responses	0.8	1.0	1.9	0.9	0.8	-1.4	-1.0	0.6	1.1
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.8	0.9	0.9	-1.3	-1.0	0.6	0.7
Condit. Reinf. active responses	0.5	0.7	1.4	0.7	0.6	-1.0	-0.8	0.6	1.2
Condit. Reinf. inactive responses	0.1	0.1	0.5	-0.1	-0.1	0.3	-0.0	0.2	0.7
Condit. Reinf. lever presses	2.7	3.8	5.0	2.0	1.9	-2.2	-1.9	1.8	1.8
Condit. Reinf. lever reinforcers received	0.8	1.1	1.6	0.9	0.9	-1.2	-1.0	0.8	1.3
Conditioned reinforcement - actives	0.2	0.4	0.5	-0.7	-0.7	0.5	0.7	-0.4	-0.6
Conditioned reinforcement - inactives	0.3	0.4	1.5	-0.5	-0.5	0.3	0.6	-0.5	-1.2
Conditioned locomotion	0.7	0.9	1.7	-0.8	-0.8	1.1	0.9	-0.4	-1.3
Patch foraging indifference point 0 sec	0.6	1.2	1.9	0.9	0.9	-1.0	-1.0	1.1	1.4
Patch foraging indifference point AUC	2.1	3.0	4.7	1.9	1.8	-2.2	-1.5	1.7	1.2
Delay disc. indifference point, 0s delay	0.7	0.8	1.1	0.8	0.9	-0.9	-0.9	1.0	0.9
Delay disc. indifference point, 16s delay	0.4	0.5	0.9	0.8	1.0	0.2	-0.6	0.9	0.2
Delay disc. indifference point, 2s delay	2.2	2.4	2.9	1.6	1.7	-1.3	-1.6	1.5	1.5
Delay disc. indifference point, 24s delay	0.8	0.9	1.9	-0.9	-0.9	1.4	1.1	-0.7	-0.6
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.3	0.4	0.2	-0.4	0.5	0.0
Delay disc. indifference point, 8s delay	0.5	0.6	1.5	0.9	0.9	-0.0	-0.4	1.2	0.7
Indifference point function ln k	0.5	0.8	1.6	-1.0	-0.9	1.3	0.6	-0.9	-0.5
Indifference point function log k	0.5	0.8	1.6	-1.0	-0.9	1.3	0.6	-0.9	-0.5
Patch foraging total patch changes 0 sec	0.5	1.0	1.9	0.8	0.8	-0.9	-1.0	1.0	1.4
Patch foraging total patch changes 12 sec	0.2	0.3	0.8	0.5	0.5	-0.9	-0.4	0.5	0.3
Patch foraging total patch changes 18 sec	1.9	2.9	4.2	1.7	1.6	-2.1	-1.8	1.5	1.5
Patch foraging total patch changes 24 sec	2.2	3.8	5.0	1.9	1.8	-2.2	-1.9	1.8	1.9
Patch foraging total patch changes 6 sec	3.1	4.7	5.7	2.3	2.3	-2.4	-2.0	2.2	1.8
Patch foraging time to switch 0 sec	1.3	2.7	2.9	-1.7	-1.6	1.7	1.7	-1.5	-1.7
Patch foraging water rate 0 sec	1.6	3.3	4.4	1.8	1.8	-2.1	-1.9	1.5	1.8
Patch foraging water rate 12 sec	0.1	0.2	0.7	-0.5	-0.5	0.5	0.1	-0.8	0.1
Patch foraging water rate 18 sec	0.6	1.0	2.0	-0.9	-0.8	1.3	0.6	-1.4	-0.7
Patch foraging water rate 24 sec	0.1	0.2	0.3	0.4	0.4	-0.5	-0.5	0.4	0.3
Patch foraging water rate 6 sec	1.1	1.6	2.1	1.2	1.3	-1.2	-1.5	1.0	1.3
Seeking ratio, delayed vs. immediate footshock	1.5	1.9	2.4	1.4	1.5	-1.3	-1.3	1.5	0.9
Distance traveled before self-admin	3.2	4.1	4.9	2.2	2.2	-1.4	-2.2	2.0	2.1
Distance traveled after self-admin	0.1	0.1	0.1	0.3	0.3	0.2	-0.3	0.3	0.3
Extensor digitorum longus weight	0.8	3.1	4.7	-1.8	-1.8	2.2	1.8	-1.6	-1.3
Bone: elastic displacement	2.9	3.4	3.8	1.9	1.9	-1.7	-1.8	1.9	1.7
Bone: elastic work	9.1	11.9	15.0	3.4	3.4	-3.1	-3.4	3.9	3.5
Bone: endosteal estimation	0.0	0.0	0.0	-0.0	-0.1	-0.2	0.1	0.0	-0.2
Bone: endosteal perimeter	0.1	0.1	0.5	-0.2	-0.2	0.1	0.4	-0.2	-0.7
Epididymis fat weight	8.7	29.8	33.2	-5.5	-5.4	5.6	5.2	-5.8	-5.2
Delta time in closed arm before/after self-admin	2.4	2.2	3.3	1.7	1.7	-0.9	-1.8	1.1	1.4
Delta time in open arm before/after self-admin	5.3	5.3	7.7	-2.6	-2.6	1.2	2.8	-1.8	-2.4
Diff in mean of infusions in LGA sessions	0.4	0.5	0.7	-0.8	-0.8	0.3	0.8	-0.6	-0.8
Delay discount exponential model param	0.7	0.8	1.5	-0.9	-1.1	0.1	0.7	-1.2	-0.8
Extinction: sum of active levers before priming	0.5	0.6	1.0	-0.9	-1.0	0.5	0.9	-0.4	-0.5
Active lever presses in extinction session 6	0.2	0.2	0.7	-0.3	-0.4	0.5	0.1	-0.3	0.8
Bone: final force	0.5	0.9	2.3	0.7	0.7	-0.4	-0.6	1.5	1.2
Bone: final moment	0.6	0.9	2.3	0.7	0.7	-0.4	-0.7	1.5	1.2
Food consumed during 24 hour testing period	0.5	0.6	2.2	0.5	0.6	-0.2	-0.9	0.4	1.5
Glucose	1.1	1.8	2.3	1.5	1.5	-1.3	-1.2	1.2	1.3
Heart weight	1.1	1.6	2.4	-1.5	-1.5	1.3	1.3	-1.1	-0.7
Delay discount hyperbolic model param	1.1	1.3	2.2	-1.2	-1.3	0.3	1.0	-1.5	-1.1
Intermittent access intake day 1-15 change	0.0	0.1	0.3	-0.2	-0.2	-0.0	-0.1	-0.5	0.0
Intermittent access intake escalation	0.1	0.1	0.3	-0.4	-0.4	0.0	0.1	-0.6	-0.2
Intermittent access intake escalation 2	0.1	0.1	0.2	0.4	0.4	-0.4	-0.4	0.1	0.3
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.3	0.4	0.4	-0.5	-0.3	0.5	0.2
Intermitt. access day 15 inactive lever presses	0.4	0.9	3.2	0.8	0.8	-1.8	-0.9	0.3	0.1
Intermitt. access escalation Index	1.2	1.7	2.7	-1.3	-1.1	1.6	1.0	-1.5	-1.1
Intermittent access day 1 total infusions	0.3	0.5	1.4	-0.5	-0.5	0.3	0.9	-0.2	-1.2
Intermittent access day 15 total infusions	0.9	1.3	2.3	-1.2	-1.2	0.6	1.3	-0.9	-1.5
Intermittent access terminal intake (last 3 days)	1.3	1.7	2.9	-1.3	-1.3	1.0	1.3	-1.1	-1.7
Intermittent access total infusions	0.5	0.6	1.4	-0.7	-0.7	0.4	0.9	-0.4	-1.2
Intermittent access day 1 locomotion	0.1	0.2	0.5	-0.2	-0.2	0.2	0.6	0.3	-0.7
Intermittent access day 15 total locomotion	0.3	0.6	0.9	-0.7	-0.8	0.8	0.9	-0.5	-0.9
Intermittent access total locomotion	0.6	0.7	1.1	-0.8	-0.9	0.7	1.1	-0.4	-1.0
Intermittent access standard deviation	0.1	0.1	0.4	-0.1	-0.1	-0.4	0.3	-0.1	-0.6
Left kidney weight	0.0	0.2	0.3	-0.5	-0.5	0.5	0.4	-0.2	-0.2
Right kidney weight	0.2	0.7	1.0	-0.9	-0.9	1.0	0.9	-0.8	-0.7
Cocaine induced anxiety	0.2	0.3	0.8	0.4	0.4	-0.9	-0.5	0.4	0.3
Post-drug Anxiety	0.1	0.1	0.3	-0.4	-0.4	-0.0	0.1	-0.6	-0.0
Baseline Anxiety	0.2	0.3	0.6	-0.5	-0.5	0.6	0.2	-0.8	0.0
Tail length	0.4	1.6	2.1	-1.4	-1.3	1.3	1.2	-1.5	-0.8
Length with tail	0.6	2.8	3.5	-1.8	-1.6	1.7	1.5	-1.9	-1.4
Length without tail	0.5	1.8	2.3	-1.3	-1.2	1.4	1.0	-1.5	-1.5
Times rat made contact with spout	0.2	0.3	1.1	0.3	0.2	0.2	-0.4	0.4	1.0
Lifetime Intake	0.8	1.0	2.4	-0.9	-0.9	0.5	1.2	-0.6	-1.6
Liver weight, left	5.4	8.9	10.0	-3.0	-3.0	3.1	2.9	-3.2	-2.9
Liver weight, right	3.9	6.8	7.2	-2.6	-2.7	2.7	2.6	-2.5	-2.4
Locomotor activity	0.0	0.1	0.2	0.1	0.2	-0.4	-0.3	-0.3	0.2
Locomotor testing distance	0.1	0.1	0.2	0.3	0.3	-0.4	-0.3	-0.3	0.1
Locomotor testing rearing	0.1	0.2	0.6	0.3	0.3	-0.8	-0.4	-0.2	0.3
Locomotion in novel chamber	1.5	1.9	3.1	1.7	1.8	-0.5	-1.6	1.3	1.0
Locomotion in novel chamber post-restriction	0.1	0.1	0.5	-0.1	-0.0	0.7	0.0	0.2	0.0
Fecal boli incidents, locomotor time 1	1.2	1.7	2.1	-1.4	-1.4	1.2	1.3	-1.4	-1.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	0.2	0.3	0.2	0.0	0.6	-0.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.4	-0.2	-0.2	0.1	0.1	0.5	0.6
Bouts of movement, locomotor time 1	0.4	0.5	0.6	0.7	0.7	-0.5	-0.7	0.7	0.7
Total resting periods, locomotor time 1	0.1	0.1	0.3	0.4	0.4	-0.3	-0.4	0.4	0.5
Rest time, locomotor task time 1	0.0	0.1	0.1	-0.3	-0.4	-0.2	0.2	-0.1	-0.1
Distance moved, locomotor task time 1	0.1	0.2	0.4	0.5	0.6	-0.3	-0.5	0.6	0.2
Vertical activity count, locomotor time 1	0.0	0.1	0.2	0.1	0.2	0.0	0.1	0.5	-0.2
Time >=10cm from walls, locomotor time 2	0.5	0.8	1.4	-1.2	-1.1	0.8	1.2	0.1	-0.3
Bouts of movement, locomotor time 2	0.3	0.4	0.7	0.7	0.7	-0.6	-0.8	0.6	0.6
Total resting periods, locomotor time 2	0.1	0.2	0.3	0.4	0.4	-0.4	-0.6	0.4	0.5
Rest time, locomotor task time 2	0.2	0.3	0.7	0.4	0.2	-0.8	-0.4	0.1	0.9
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.3	0.4	0.0	-0.1	0.4	-0.5
Vertical activity count, locomotor time 2	0.2	0.3	1.1	0.2	0.4	0.1	0.1	0.6	-1.0
Light reinforcement 1	0.0	0.0	0.0	0.1	0.1	0.1	-0.0	0.0	-0.0
Light reinforcement 2	0.3	0.4	0.5	0.7	0.7	-0.5	-0.7	0.7	0.5
Bone: marrow area	0.0	0.0	0.0	-0.0	-0.0	-0.2	0.1	0.0	-0.2
Bone: maximum diameter	0.3	0.5	1.1	0.7	0.7	-0.5	-0.7	1.1	0.6
Bone: maximum force	0.6	1.0	2.1	0.9	0.9	-0.6	-0.9	1.4	1.1
Bone: maximum moment	0.6	1.1	2.1	0.9	1.0	-0.6	-0.9	1.5	1.2
Mean time between licks in bursts	0.5	1.2	1.7	-1.0	-1.0	1.3	1.0	-1.0	-1.3
Mean num. licks in bursts	0.4	0.6	2.2	-0.7	-0.6	1.5	0.6	-0.7	0.3
Cd content in liver	0.7	0.8	2.0	0.9	0.9	-1.4	-0.7	0.6	-0.3
Co content in liver	0.6	0.6	1.6	0.6	0.7	-1.3	-0.5	0.8	0.7
Cu content in liver	1.9	2.2	2.6	1.5	1.4	-1.6	-1.5	1.3	1.5
Fe content in liver	1.9	2.3	3.9	-1.6	-1.7	0.9	2.0	-1.1	-1.7
K content in liver	0.1	0.1	0.2	-0.4	-0.3	0.4	0.3	-0.3	-0.2
Mg content in liver	1.0	1.1	1.8	0.9	0.8	-1.4	-0.8	1.3	0.9
Mn content in liver	0.2	0.3	0.4	0.5	0.5	-0.6	-0.6	0.4	0.4
Na content in liver	0.4	0.4	1.3	-0.4	-0.3	0.2	0.7	-0.5	-1.1
Rb content in liver	0.1	0.1	0.1	-0.4	-0.3	-0.3	0.2	-0.1	-0.2
Se content in liver	1.2	1.4	3.5	1.0	0.8	-1.9	-0.7	1.5	0.7
Sr content in liver	0.5	0.4	1.1	-0.7	-0.6	0.6	0.4	-1.0	-0.2
Zn content in liver	0.3	0.3	0.7	-0.6	-0.7	-0.0	0.8	-0.2	-0.6
Bone: minimum diameter	0.0	0.1	0.1	0.4	0.3	-0.2	-0.2	0.3	-0.2
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.5	0.6	-0.2	-0.4	0.4	0.4
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.3	-0.4	0.1	0.2	-0.4	-0.2
Total zone transitions, hab. session 1	0.0	0.0	0.1	0.1	0.2	-0.2	-0.0	0.0	-0.3
Total locomotion distance, hab. session 1	0.1	0.1	0.3	0.3	0.4	-0.3	-0.5	0.0	0.2
Locomotion velocity, hab. session 1	0.3	0.4	0.6	0.6	0.7	-0.7	-0.8	0.5	0.4
Time in familiar zone, hab. session 2	0.3	0.3	0.5	0.5	0.5	-0.7	-0.6	0.3	0.7
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.3	0.3	-0.0	-0.2	0.5	-0.0
Total zone transitions, hab. session 2	0.4	0.5	0.9	-0.6	-0.6	0.5	0.7	-0.8	-0.9
Total locomotion distance, hab. session 2	0.1	0.2	0.5	0.4	0.3	-0.7	-0.4	-0.1	0.0
Locomotion velocity, hab. session 2	0.1	0.2	0.5	0.4	0.4	-0.7	-0.4	-0.1	-0.0
Novel to familiar place preference ratio	0.8	0.9	1.1	-1.0	-1.0	1.1	1.0	-0.9	-0.8
Novelty place preference	1.1	1.2	1.5	-1.1	-1.1	1.2	1.1	-1.0	-0.9
Time in novel zone, NPP test	1.1	1.2	1.5	-1.2	-1.2	1.2	1.1	-1.0	-0.9
Total zone transitions, NPP test	0.0	0.1	0.2	-0.1	-0.1	-0.3	0.1	-0.2	-0.4
Total locomotion distance, NPP test	1.0	1.3	2.7	1.2	1.1	-1.6	-1.3	0.7	0.6
Locomotion velocity, NPP test	1.1	1.5	3.0	1.3	1.2	-1.7	-1.4	0.8	0.6
Intraocular pressure	0.9	1.4	1.7	1.3	1.3	-1.1	-1.2	1.1	0.9
Delta distance traveled before/after self-admin	2.7	2.8	3.4	-1.8	-1.8	1.5	1.8	-1.5	-1.6
Delta ambulatory time before/after self-admin	1.9	2.3	3.0	-1.7	-1.7	0.8	1.7	-1.4	-1.7
Parametrial fat weight	6.0	14.2	17.4	-3.8	-3.8	3.7	3.6	-4.2	-3.3
Pavlov. Cond. lever latency	0.0	0.1	0.2	-0.1	-0.1	-0.1	0.1	-0.5	-0.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	-0.2	0.1	0.1	-0.0	-0.3
Pavlov. Cond. change in total contacts	0.3	0.3	0.6	0.6	0.6	-0.5	-0.5	0.8	0.4
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	0.1	-0.0	-0.1	0.4	-0.0
Pavlov. Cond. latency score	0.0	0.0	0.1	0.0	-0.0	0.1	-0.0	0.3	-0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.0	0.0	0.3	0.1	0.3	-0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.4	-0.4	0.4	0.4	-0.5	-0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	0.6	0.5	-0.9	-0.5	0.5	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.3	0.2	-0.2	-0.2	0.5	0.0
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	0.0	0.0	0.1	0.3	-0.2
Pavlov. Cond. lever latency	2.5	3.5	5.0	-1.9	-1.9	2.2	1.9	-1.5	-1.6
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	0.5	0.5	-0.6	-0.5	0.5	0.4
Pavlov. Cond. change in total contacts	1.5	2.4	3.5	1.5	1.5	-1.9	-1.5	1.4	1.4
Pavlov. Cond. index score	2.3	3.1	4.6	1.8	1.8	-2.1	-1.8	1.5	1.5
Pavlov. Cond. latency score	2.8	3.7	5.1	2.0	1.9	-2.3	-1.9	1.7	1.7
Pavlov. Cond. lever contacts	1.6	2.2	3.4	1.5	1.4	-1.8	-1.5	1.2	1.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.2	-0.1	-0.1	0.5	0.1	-0.1	-0.0
Pavlov. Cond. intertrial magazine entries	0.4	0.6	0.8	-0.8	-0.8	0.9	0.7	-0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.4	3.7	1.6	1.5	-1.9	-1.5	1.3	1.3
Pavlov. Cond. response bias	1.2	1.6	2.6	1.3	1.3	-1.6	-1.4	1.0	1.0
Time in closed arm before self-admin	1.7	2.2	3.2	-1.5	-1.4	1.2	1.6	-1.2	-1.8
Time in closed arm after self-admin	0.3	0.3	0.7	0.7	0.8	0.5	-0.6	-0.1	-0.4
Time in open arm before self-admin	2.4	2.6	4.3	1.6	1.5	-1.2	-1.8	1.2	2.1
Time in open arm after self-admin	0.6	0.6	1.1	-1.0	-1.1	0.1	1.0	-0.5	-0.5
Bone: periosteal estimation	0.3	0.7	1.1	0.8	0.8	-0.7	-0.7	1.1	0.6
Bone: periosteal perimeter	0.2	0.3	0.7	0.6	0.6	-0.2	-0.4	0.8	0.1
Bone: post-yield work	0.4	0.6	1.3	-0.7	-0.6	1.1	0.8	-0.5	-0.8
Progressive ratio test 1 active lever presses	0.4	0.5	1.0	0.6	0.7	-1.0	-0.6	0.8	0.2
Progressive ratio test 1 breakpoint	0.5	0.6	1.3	0.7	0.7	-1.1	-0.7	0.8	0.2
Progressive ratio test 1 inactive lever presses	1.0	1.5	2.1	1.3	1.3	-1.4	-1.2	1.5	0.4
Progressive ratio test 2 active lever presses	0.4	0.4	0.7	0.6	0.6	-0.8	-0.6	0.7	0.4
Progressive ratio test 2 breakpoint	0.4	0.4	0.7	0.6	0.6	-0.9	-0.6	0.7	0.4
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	0.3	0.3	-0.4	-0.3	0.1	-0.1
Incentive Sensitization - Responses	0.0	0.0	0.0	0.1	-0.1	-0.0	0.0	0.2	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.0	-0.1	-0.0	0.1	0.1	0.1
Sum of active levers in priming session hrs 5-6	0.9	0.8	1.5	-1.1	-1.2	0.6	1.1	-0.6	-0.5
Progressive ratio	0.2	0.3	1.4	-0.0	-0.1	-0.3	-0.2	0.4	1.2
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.3	-0.3	-0.1	0.3	-0.4	-0.4
Seeking ratio, punishment vs. effort	0.2	0.2	1.3	0.1	0.2	0.2	0.1	-0.3	-1.1
Retroperitoneal fat weight	0.8	3.5	5.8	-1.7	-1.6	1.8	1.4	-2.4	-2.2
Reaction time number correct	0.6	1.2	1.6	-1.2	-1.2	0.9	1.0	-1.3	-1.0
Reaction time mean minus median	0.2	0.4	0.9	-0.5	-0.5	0.2	0.5	-0.8	-0.9
Reaction time mean minus median AUC	1.2	3.0	5.1	-1.5	-1.5	1.3	1.7	-1.9	-2.3
Reaction time num false alarms	5.7	8.0	8.5	2.9	2.9	-2.6	-2.9	2.8	2.9
Reaction time num false alarms AUC	5.4	8.4	9.4	2.9	2.9	-2.6	-3.0	2.9	3.1
Reaction time trials correct on left	0.6	1.2	1.6	-1.2	-1.2	0.9	1.0	-1.3	-1.0
Reaction time trials on left	0.7	1.3	1.6	-1.2	-1.2	1.0	1.0	-1.3	-1.0
Reaction time mean	0.7	1.1	1.9	-0.9	-1.0	0.5	1.0	-1.2	-1.4
Reaction time mean AUC	0.6	0.9	1.8	-0.8	-0.9	0.5	0.9	-1.1	-1.3
Median of all reaction times	0.5	0.8	1.5	-0.8	-0.8	0.2	0.8	-1.0	-1.2
Reaction time omissions	1.4	2.1	3.3	-1.4	-1.4	1.8	1.4	-1.4	-1.3
Reaction time false alarm rate	6.2	8.5	9.4	2.9	3.0	-2.6	-2.9	3.1	3.0
Reaction time premature initiation rate	0.3	0.4	0.7	-0.6	-0.5	0.8	0.6	-0.4	-0.6
Reaction time premature initiations	0.4	0.7	1.1	-0.9	-0.8	1.0	0.7	-0.8	-0.8
Std. dev. reaction times	0.7	1.3	1.8	-1.1	-1.1	0.9	1.1	-1.3	-1.3
Reaction time trials completed	0.7	1.3	1.6	-1.2	-1.2	1.0	1.0	-1.3	-1.0
Reaction time trials AUC	0.5	0.9	1.3	-1.1	-1.0	0.8	0.8	-1.2	-0.8
Run reversals in cocaine runway, females	0.3	0.3	1.1	-0.3	-0.3	0.7	0.2	-1.0	-0.6
Run reversals in cocaine runway, males	0.3	0.3	0.8	-0.3	-0.3	0.9	0.4	-0.3	-0.8
Latency to leave start box in cocaine runway	1.6	1.8	6.8	0.9	0.8	-0.8	-1.2	0.5	2.6
Latency to leave start box in cocaine runway, F	0.5	0.6	2.8	0.4	0.3	-0.4	-0.7	0.2	1.7
Latency to leave start box in cocaine runway, M	0.8	0.7	2.9	0.6	0.5	-0.1	-0.8	0.2	1.7
Std. dev. time between licks in bursts	0.1	0.2	0.5	-0.2	-0.2	0.7	0.3	-0.3	-0.5
Total sessions with >9 infusions	0.8	1.0	2.9	-0.8	-0.7	0.8	1.0	-0.4	-1.7
Short access day 1 total inactive lever presses	4.0	5.3	7.0	-2.3	-2.2	2.2	2.4	-1.9	-2.6
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.0	0.0	-0.3	0.1	0.3	-0.2
Short access day 1 total infusions	1.2	1.5	4.9	-1.0	-1.0	0.4	1.3	-0.6	-2.2
Short access day 10 total infusions	0.7	0.9	2.4	-0.7	-0.7	0.6	1.0	-0.6	-1.6
Short access total infusions	0.6	0.7	2.9	-0.6	-0.5	0.3	0.9	-0.3	-1.7
Short access day 1 locomotion	0.1	0.1	0.7	-0.0	0.0	-0.3	0.1	0.2	-0.8
Short access day 10 total locomotion	0.5	1.0	2.2	0.8	0.8	-1.5	-0.8	1.1	0.7
Short access total locomotion	0.4	0.4	1.1	0.6	0.6	-0.8	-0.4	1.1	-0.0
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.2	0.2	-0.5	-0.0	0.4	-0.0
Compulsive drug intake	0.9	1.0	1.5	-1.1	-1.1	0.9	1.2	-0.9	-0.9
One hour access (shock baseline)	0.1	0.1	0.3	0.4	0.4	-0.5	-0.4	0.3	0.1
Social response proportion	2.5	2.8	3.7	-1.8	-1.7	1.7	1.9	-1.3	-1.6
Social responses	1.8	2.3	2.8	-1.7	-1.6	1.3	1.7	-1.4	-1.5
Social time	1.8	2.5	3.5	-1.5	-1.5	1.6	1.9	-1.2	-1.7
Soleus weight	2.2	6.5	7.9	-2.6	-2.6	2.8	2.7	-2.2	-2.3
Bone: stiffness	1.8	2.9	3.4	-1.9	-1.8	1.7	1.7	-1.6	-1.5
Tibialis anterior weight	2.6	9.0	10.4	-3.1	-3.1	3.2	3.2	-2.8	-2.4
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.9	-0.4	-0.3	0.9	0.5	-0.2	-0.6
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.9	0.6	0.7	-0.9	-0.5	0.7	0.0
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.1	-0.1	0.4	0.0	-0.4	-0.2
Time to tail flick, test, after self-admin	1.1	1.1	3.3	0.8	0.8	-0.7	-1.2	0.2	1.8
Delta time to tail flick, vehicle, before/after SA	0.9	0.8	2.1	0.8	0.7	-1.4	-0.8	0.6	0.8
Delta time to tail flick, test, before/after SA	0.7	0.8	1.4	0.8	0.7	-1.2	-0.9	0.7	1.0
Tibia length	0.0	0.0	0.1	0.2	0.2	0.2	-0.2	0.3	0.0
Ambulatory time before self-admin	1.0	1.4	2.1	1.4	1.5	-0.2	-1.2	1.4	1.1
Ambulatory time after self-admin	0.0	0.0	0.2	-0.1	-0.1	0.5	0.1	0.0	0.0
Bone: tissue strength	1.7	1.7	3.1	1.3	1.3	-0.8	-1.3	1.8	1.3
Total heroin consumption	1.8	2.1	3.5	-1.7	-1.9	1.4	1.5	-1.3	-0.5
Bone: trabecular number	2.5	4.1	5.0	-2.2	-2.2	2.0	2.1	-2.0	-1.5
Bone: trabecular spacing	0.2	0.3	0.6	0.5	0.6	-0.3	-0.5	0.8	0.5
Bone: trabecular thickness	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	0.1
Bone: trabecular tissue density	1.2	1.7	2.6	1.4	1.4	-1.6	-1.3	1.2	0.9
Water consumed over 24 hours	0.1	0.1	0.2	0.2	0.2	-0.3	-0.3	0.2	0.4
Number of responses in last shaping day	1.0	1.1	1.8	1.1	1.1	-1.2	-0.9	1.3	0.2