Rxrb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	alternative TSS	XM_006255960.5	0.34	0.15	6.7e-03	0.09	0.02	0.02	0.06	3.1e-03	1.2e-01	9.3e-02	1.2e-02
2	OFC	alternative TSS	XM_006255961.5	0.33	0.15	8.7e-03	0.06	0.01	0	0.05	1.3e-02	1.5e-01	2.7e-01	2.5e-02
3	Brain	isoform ratio	NM_206849.3	0.04	0.03	4.5e-03	0.03	0.02	0.01	0.02	4.3e-04	1.1e-02	5.6e-02	8.0e-03
4	Brain	gene expression	Rxrb	0.07	0.04	1.4e-05	0.05	0.04	0.04	0.05	2.4e-05	1.5e-04	1.6e-04	4.0e-05
5	pVTA	gene expression	Rxrb	0.05	0.03	3.4e-03	0.03	0.02	0.01	0.01	3.7e-03	1.2e-02	2.3e-02	2.1e-02
6	Brain	alternative TSS	NM_206849.3	0.06	0.04	1.5e-04	0.02	0.02	0.01	0.02	3.7e-03	2.4e-03	3.0e-02	1.2e-02
7	Brain	alternative TSS	XM_006255960.5	0.05	0.03	1.0e-03	0.02	0.02	0.01	0.01	1.1e-02	6.7e-03	2.1e-02	1.3e-02
8	NAcc	gene expression	Rxrb	0.09	0.05	1.1e-06	0.05	0.04	0.05	0.06	4.7e-08	2.1e-07	1.9e-08	6.6e-09
9	PL	gene expression	Rxrb	0.12	0.07	5.3e-07	0.07	0.06	0.07	0.06	2.8e-08	9.1e-07	2.3e-08	2.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	1.1	2.0	4.0	1.9	-1.9	-0.3	2.0	1.8	1.0	-1.1	0.8	-0.6
Area under the delay curve	0.1	0.2	0.5	-0.6	0.6	0.3	-0.7	-0.3	-0.4	0.3	-0.4	-0.1
BMI with tail	1.4	4.9	12.1	1.2	-1.2	3.5	-1.4	-2.1	-2.8	2.7	-2.1	1.5
BMI without tail	0.6	3.0	6.2	0.5	-0.5	2.5	-2.3	-1.6	-2.3	2.3	-1.3	0.6
Body weight	2.3	10.2	16.1	-1.1	1.1	3.5	-3.9	-3.8	-3.9	4.0	-3.3	2.4
Weight adjusted by age	1.3	3.7	7.2	-1.1	1.1	1.0	-1.9	-2.6	-1.9	1.9	-2.7	2.3
Bone surface	0.1	0.1	0.3	-0.4	0.4	-0.3	-0.0	0.6	0.5	-0.4	0.4	-0.2
Bone volume	0.1	0.2	0.6	0.6	-0.6	0.0	0.5	0.8	0.4	-0.4	0.4	-0.2
Breakpoint value in progressive ratio session	0.2	0.4	1.1	-0.3	0.3	-0.4	0.4	0.7	0.8	-0.7	0.9	-1.1
Number of licking bursts	0.4	1.3	3.3	-1.8	1.8	-1.2	0.3	0.6	1.1	-0.9	0.8	-0.9
Context. condit. distance diff. score	3.2	3.9	6.4	-2.0	2.0	-2.3	2.5	2.0	2.3	-2.2	1.0	-0.6
Locomotion velocity, session 1	1.6	1.8	3.9	-0.8	0.8	-2.0	0.9	1.5	1.6	-1.6	1.1	-1.1
Locomotion distance, session 1	0.9	1.2	2.9	1.1	-1.1	-0.5	1.7	1.4	1.0	-1.1	0.8	-0.4
Locomotion velocity, session 2	0.7	0.8	1.4	-0.7	0.7	-0.8	0.6	1.2	1.1	-1.0	1.0	-0.9
Locomotion distance, session 2	0.3	0.4	2.4	0.2	-0.2	-0.2	1.6	0.5	0.4	-0.5	-0.1	0.3
Locomotion velocity, session 3	0.3	0.4	1.2	0.9	-0.9	0.0	-0.4	0.2	0.3	-0.4	1.1	-0.4
Locomotion distance, session 3	1.2	1.4	2.2	0.8	-0.8	-0.9	1.5	1.1	1.4	-1.5	1.5	-0.5
Stereotopy head waving bouts, day 3	1.2	1.4	3.1	-1.7	1.7	-0.0	-1.7	-1.5	-0.6	0.8	-0.8	0.7
Stereotopy head waving duration, day 3	0.7	0.9	2.6	-1.3	1.3	-0.2	-1.6	-1.2	-0.5	0.6	-0.4	0.2
Locomotion velocity, session 7	1.1	1.2	5.7	0.7	-0.7	-0.8	2.4	1.1	1.0	-1.1	0.2	0.3
Locomotion distance, session 7	2.3	3.0	8.3	0.8	-0.8	-1.7	2.9	1.8	1.9	-2.1	1.2	-1.0
Stereotopy head waving bouts, day 7	0.7	0.9	2.9	-0.5	0.5	-0.9	-0.2	0.6	0.9	-0.9	1.7	-1.2
Stereotopy head waving duration, day 7	0.2	0.2	0.8	-0.3	0.3	-0.2	-0.9	-0.3	0.1	-0.1	0.8	-0.5
Locomotion velocity, session 8	2.4	2.9	8.7	-2.9	2.9	-1.9	0.1	0.8	1.5	-1.3	0.6	-0.7
Locomotion distance, session 8	1.8	2.6	7.7	-1.4	1.4	-1.7	2.8	1.5	1.9	-1.8	0.5	0.0
Degree of sensitization distance	0.5	0.5	1.8	-1.3	1.3	-0.6	-0.0	0.1	0.2	-0.1	-0.6	-0.4
Degree of sensitization stereotypy	1.6	1.8	5.0	-0.0	0.0	-1.2	0.8	1.5	1.4	-1.5	2.2	-1.6
Conditioned locomotion	0.6	0.7	1.0	-0.7	0.7	0.9	-1.0	-0.7	-0.8	1.0	-1.0	0.9
Cocaine response after cond. corrected	0.4	0.6	1.6	-0.3	0.3	0.8	0.3	-0.7	-0.6	0.7	-1.3	1.2
Cocaine response after cond. not corrected	0.6	0.9	2.0	-1.4	1.4	0.5	-0.8	-0.8	-0.5	0.7	-1.0	0.7
Cocaine response before conditioning	1.3	1.6	6.4	-1.8	1.8	-0.2	-2.5	-0.8	-0.3	0.5	0.3	-0.5
Saline control response	1.6	2.3	3.8	1.4	-1.4	1.9	-1.9	-1.1	-1.9	1.8	-0.7	0.7
Bone: connectivity density	0.4	0.7	2.0	1.2	-1.2	-0.1	1.4	1.1	0.5	-0.5	-0.1	0.1
Bone: cortical apparent density	1.2	1.8	3.7	1.5	-1.5	1.9	-1.0	-1.0	-1.5	1.5	-0.9	1.0
Bone: cortical area	0.1	0.1	0.3	-0.6	0.6	0.2	-0.6	0.2	-0.1	0.2	0.3	0.1
Bone: cortical porosity	1.9	2.1	4.9	-0.5	0.5	-1.9	0.3	1.1	1.5	-1.6	2.2	-1.9
Bone: cortical porosity	1.8	1.9	4.7	-1.0	1.0	-2.2	0.2	0.8	1.5	-1.5	1.9	-1.4
Bone: cortical thickness	0.5	0.8	2.4	1.5	-1.5	1.3	-0.4	0.4	-0.6	0.5	0.6	0.2
Bone: cortical thickness	1.4	1.7	4.1	1.6	-1.6	2.0	-1.2	-0.6	-1.3	1.3	-0.3	1.0
Bone: cortical tissue density	1.1	1.7	3.3	1.4	-1.4	1.8	-1.1	-1.1	-1.5	1.4	-0.9	1.0
Condit. Reinf. active minus inactive responses	0.7	0.8	1.8	0.3	-0.3	-1.3	0.5	1.2	0.9	-1.0	0.7	-1.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.6	-0.6	0.1	-0.7	0.2	-0.3	0.2	-0.0	-0.3
Condit. Reinf. active responses	0.4	0.5	0.8	0.8	-0.8	-0.8	0.7	0.9	0.6	-0.7	0.1	-0.6
Condit. Reinf. inactive responses	0.9	1.1	2.7	1.7	-1.7	-0.2	1.6	1.0	0.6	-0.7	0.4	-0.5
Incentive salience index mean	1.2	1.5	2.8	-0.5	0.5	-1.7	1.3	1.6	1.4	-1.4	0.7	-1.2
Condit. Reinf. lever presses	1.3	2.0	4.4	-1.2	1.2	-1.6	2.1	1.5	1.6	-1.5	0.4	-1.1
Condit. Reinf. active minus inactive responses	0.2	0.3	1.3	-0.7	0.7	-0.2	-1.2	-0.2	-0.3	0.3	0.1	-0.7
Condit. Reinf. active-inactive response ratio	0.5	0.7	2.2	-1.5	1.5	-0.5	-1.3	-0.4	-0.3	0.4	-0.3	-0.2
Condit. Reinf. active responses	0.1	0.1	0.8	0.0	-0.0	-0.2	-0.5	0.1	0.1	-0.1	0.4	-0.9
Condit. Reinf. inactive responses	0.2	0.3	1.1	1.1	-1.1	0.6	-0.0	0.0	-0.2	0.1	0.4	-0.3
Condit. Reinf. lever presses	0.9	1.3	2.3	0.4	-0.4	-1.3	1.0	1.5	1.2	-1.3	1.5	-1.2
Condit. Reinf. lever reinforcers received	0.2	0.3	1.1	-0.1	0.1	-0.6	-0.3	0.4	0.4	-0.4	0.7	-1.1
Conditioned reinforcement - actives	0.1	0.2	0.7	0.6	-0.6	0.8	0.6	0.2	-0.2	0.1	-0.4	-0.2
Conditioned reinforcement - inactives	0.0	0.1	0.5	0.4	-0.4	0.3	0.3	-0.3	-0.3	0.2	-0.7	-0.2
Conditioned locomotion	0.1	0.1	0.4	-0.1	0.1	-0.1	0.5	-0.1	-0.2	0.1	-0.6	0.3
Patch foraging indifference point 0 sec	0.8	2.3	4.5	1.1	-1.1	2.1	-2.1	-1.6	-1.8	1.7	-0.9	0.0
Patch foraging indifference point AUC	0.1	0.3	0.6	-0.5	0.5	-0.6	-0.7	-0.4	0.4	-0.3	0.6	-0.8
Delay disc. indifference point, 0s delay	0.2	0.3	1.0	-1.0	1.0	0.2	-0.2	-0.4	-0.1	0.2	-0.1	0.5
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	0.6	-0.6	0.5	0.1	0.1	-0.3	0.1	-0.1	-0.0
Delay disc. indifference point, 2s delay	0.7	0.7	2.4	-1.5	1.5	-0.3	-0.9	-0.7	-0.2	0.2	-0.7	-0.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.7	-0.2	0.2	0.1	-0.8	-0.6	-0.5	0.4	-0.8	0.2
Delay disc. indifference point, 4s delay	0.6	0.7	2.4	-0.9	0.9	0.8	-1.5	-0.7	-0.6	0.7	-0.0	-0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	-0.2	0.2	-0.0	-0.3	-0.2	-0.2	0.2	-0.6	0.3
Indifference point function ln k	0.3	0.8	1.4	-0.9	0.9	-1.0	0.1	1.2	1.0	-0.9	1.0	-0.6
Indifference point function log k	0.3	0.8	1.4	-0.9	0.9	-1.0	0.1	1.2	1.0	-0.9	1.0	-0.6
Patch foraging total patch changes 0 sec	0.8	2.3	4.3	1.2	-1.2	2.1	-2.0	-1.6	-1.8	1.7	-0.9	-0.0
Patch foraging total patch changes 12 sec	1.0	1.3	2.4	1.0	-1.0	1.5	-1.5	-1.5	-1.2	1.1	-0.5	0.4
Patch foraging total patch changes 18 sec	1.3	3.0	5.9	2.2	-2.2	2.4	-0.8	-1.8	-1.8	1.7	-1.0	0.7
Patch foraging total patch changes 24 sec	0.4	1.3	4.5	2.1	-2.1	1.2	0.6	-0.3	-0.6	0.4	-0.2	-0.0
Patch foraging total patch changes 6 sec	1.0	1.7	3.4	1.4	-1.4	1.9	-1.1	-1.0	-1.6	1.5	-0.9	0.2
Patch foraging time to switch 0 sec	0.7	2.7	5.7	1.2	-1.2	2.3	0.2	-1.2	-1.7	1.6	-1.9	2.4
Patch foraging water rate 0 sec	0.1	0.6	1.5	-0.4	0.4	0.1	-0.9	-1.2	-0.8	0.8	-1.0	0.4
Patch foraging water rate 12 sec	0.1	0.4	0.9	1.0	-1.0	-0.0	0.4	0.5	0.2	-0.2	0.7	-0.7
Patch foraging water rate 18 sec	0.2	0.4	0.8	0.3	-0.3	0.9	-0.8	-0.6	-0.8	0.8	-0.4	0.4
Patch foraging water rate 24 sec	0.2	0.2	0.5	0.7	-0.7	0.7	-0.3	-0.3	-0.3	0.3	0.3	-0.6
Patch foraging water rate 6 sec	0.1	0.2	0.3	0.5	-0.5	0.6	-0.6	-0.5	-0.4	0.4	-0.0	-0.0
Seeking ratio, delayed vs. immediate footshock	0.6	0.9	4.1	0.1	-0.1	0.9	-2.0	0.1	-0.0	0.2	1.3	-1.3
Distance traveled before self-admin	0.2	0.5	1.2	-0.5	0.5	1.0	-0.2	-1.1	-0.6	0.7	-0.6	0.4
Distance traveled after self-admin	0.4	0.8	3.1	-0.7	0.7	0.7	-1.8	-0.7	-0.7	0.9	-0.4	0.3
Extensor digitorum longus weight	0.1	0.4	1.7	-1.3	1.3	-0.1	0.4	-0.3	0.0	0.0	-0.3	-0.2
Bone: elastic displacement	0.2	0.3	0.6	0.8	-0.8	-0.3	0.2	0.7	0.2	-0.3	0.6	0.0
Bone: elastic work	0.0	0.1	0.2	0.0	-0.0	0.2	-0.3	0.0	-0.4	0.3	-0.1	0.4
Bone: endosteal estimation	2.0	4.8	13.8	-3.7	3.7	-0.1	-2.3	-2.2	-1.0	1.2	-1.6	0.7
Bone: endosteal perimeter	1.1	2.6	10.4	-3.2	3.2	-0.8	-0.9	-0.8	0.1	0.1	-0.7	0.2
Epididymis fat weight	2.9	14.7	34.0	5.2	-5.2	5.8	-1.0	-1.9	-4.0	3.7	-2.3	2.3
Delta time in closed arm before/after self-admin	0.5	0.5	1.3	-0.5	0.5	0.9	-0.7	-1.1	-0.8	0.8	-0.5	0.2
Delta time in open arm before/after self-admin	0.1	0.2	0.5	0.7	-0.7	-0.4	0.3	0.6	0.1	-0.2	-0.1	0.3
Diff in mean of infusions in LGA sessions	0.3	0.6	2.5	0.1	-0.1	-0.5	1.6	1.1	0.9	-0.8	0.3	-0.2
Delay discount exponential model param	0.1	0.2	0.5	0.6	-0.6	-0.2	0.7	0.2	0.3	-0.2	0.3	0.3
Extinction: sum of active levers before priming	0.3	0.4	0.9	-1.0	1.0	-0.8	0.3	-0.3	0.4	-0.3	0.1	-0.7
Active lever presses in extinction session 6	0.2	0.2	0.8	0.7	-0.7	-0.1	0.9	0.2	-0.2	0.1	-0.2	-0.1
Bone: final force	2.2	3.6	6.5	0.0	-0.0	2.5	-1.9	-2.1	-2.3	2.4	-1.9	1.9
Bone: final moment	1.7	2.7	4.5	0.0	-0.0	2.1	-1.5	-1.9	-2.0	2.0	-1.6	1.7
Food consumed during 24 hour testing period	0.8	1.6	2.8	-1.1	1.1	0.9	-0.7	-1.6	-1.2	1.3	-1.6	1.7
Glucose	2.6	4.1	12.7	-3.6	3.6	-2.8	0.4	-0.8	1.2	-1.0	-0.4	-0.3
Heart weight	0.7	1.1	3.8	-1.2	1.2	-0.0	-2.0	-0.7	-1.0	1.0	-0.8	0.2
Delay discount hyperbolic model param	0.2	0.2	0.6	0.7	-0.7	-0.2	0.8	0.2	0.2	-0.1	0.1	0.5
Intermittent access intake day 1-15 change	0.0	0.0	0.2	0.1	-0.1	-0.1	-0.3	0.4	0.2	-0.1	0.2	-0.1
Intermittent access intake escalation	0.0	0.2	0.7	0.8	-0.8	0.2	-0.4	0.5	-0.0	0.0	0.5	-0.1
Intermittent access intake escalation 2	0.1	0.2	0.6	-0.2	0.2	-0.7	-0.0	0.7	0.5	-0.5	0.6	-0.1
Intermitt. access day 1 inactive lever presses	0.1	0.7	2.9	-1.7	1.7	-0.0	-0.3	-0.1	0.3	-0.1	-0.1	-0.4
Intermitt. access day 15 inactive lever presses	0.1	0.4	1.0	-0.4	0.4	0.4	-0.5	-1.0	-0.6	0.6	-1.0	0.7
Intermitt. access escalation Index	0.4	1.2	1.9	-0.3	0.3	-0.8	1.4	1.4	1.3	-1.1	1.3	-1.1
Intermittent access day 1 total infusions	0.3	0.9	4.4	0.7	-0.7	-0.9	2.1	0.6	0.7	-1.0	-0.1	-0.6
Intermittent access day 15 total infusions	0.2	0.5	1.2	1.1	-1.1	-0.2	1.0	0.7	0.3	-0.5	0.2	-0.6
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.7	0.8	-0.8	-0.3	0.7	0.4	0.2	-0.4	0.0	-0.6
Intermittent access total infusions	0.4	0.5	1.4	0.9	-0.9	-0.5	1.2	0.5	0.3	-0.5	-0.1	-0.6
Intermittent access day 1 locomotion	0.2	0.3	0.6	0.8	-0.8	0.4	0.8	-0.3	-0.2	0.1	-0.6	0.3
Intermittent access day 15 total locomotion	0.3	1.1	1.7	0.1	-0.1	1.3	-0.9	-1.3	-1.2	1.1	-1.3	1.3
Intermittent access total locomotion	0.4	0.5	1.0	0.8	-0.8	1.0	-0.1	-0.6	-0.7	0.5	-0.8	1.0
Intermittent access standard deviation	0.4	1.9	3.7	0.7	-0.7	1.9	-1.6	-1.3	-1.6	1.6	-1.4	0.8
Left kidney weight	0.8	6.2	12.1	0.2	-0.2	3.3	-3.5	-2.7	-3.2	3.2	-1.8	1.3
Right kidney weight	1.0	7.3	12.0	0.0	-0.0	3.3	-3.4	-3.1	-3.4	3.5	-2.5	2.1
Cocaine induced anxiety	0.0	0.1	0.4	-0.6	0.6	0.0	0.0	-0.0	0.2	-0.0	0.1	-0.4
Post-drug Anxiety	0.2	0.2	0.7	-0.5	0.5	0.9	-0.5	-0.2	-0.2	0.3	-0.2	-0.4
Baseline Anxiety	0.1	0.2	0.4	-0.0	0.0	0.7	-0.6	-0.4	-0.5	0.5	-0.6	0.5
Tail length	0.8	4.1	10.3	-3.2	3.2	-0.5	-3.1	-1.8	-0.9	1.1	-0.7	0.1
Length with tail	1.7	7.7	15.1	-3.5	3.5	0.6	-3.9	-3.2	-2.2	2.5	-2.3	1.8
Length without tail	2.0	10.3	17.0	-2.2	2.2	2.5	-3.2	-4.1	-3.5	3.6	-3.7	3.3
Times rat made contact with spout	1.2	1.4	3.6	1.9	-1.9	-0.1	0.9	1.1	0.5	-0.7	1.3	-0.8
Lifetime Intake	0.2	0.3	1.0	0.8	-0.8	-0.2	1.0	0.1	0.1	-0.3	-0.3	-0.5
Liver weight, left	1.4	2.5	6.1	-2.5	2.5	0.4	-1.8	-1.8	-0.7	1.0	-1.0	0.7
Liver weight, right	1.5	2.6	9.5	-3.1	3.1	-0.2	-1.4	-1.0	-0.4	0.6	-1.0	0.2
Locomotor activity	0.5	0.8	2.3	-1.3	1.3	0.2	-1.5	-0.8	0.2	0.0	0.6	-1.0
Locomotor testing distance	0.2	0.6	1.6	-1.1	1.1	0.4	-1.0	-1.2	0.0	0.2	-0.0	-0.1
Locomotor testing rearing	0.3	1.2	2.9	-1.1	1.1	1.0	-1.2	-1.7	-0.8	1.0	-1.0	0.6
Locomotion in novel chamber	0.1	0.1	0.3	0.3	-0.3	0.6	-0.3	0.3	-0.1	0.1	0.1	0.0
Locomotion in novel chamber post-restriction	0.5	1.4	2.2	0.3	-0.3	1.4	-1.1	-1.3	-1.5	1.4	-1.5	1.2
Fecal boli incidents, locomotor time 1	0.1	0.3	1.5	0.5	-0.5	-0.3	1.2	0.0	0.0	-0.1	-0.7	0.2
Change in fecal boli incidents, locomotor task	1.3	1.4	3.2	-1.8	1.8	0.2	-1.8	-1.1	-0.5	0.7	-1.0	0.4
Time >=10cm from walls, locomotor time 1	2.5	3.1	6.8	-1.5	1.5	1.5	-1.9	-2.6	-1.6	1.9	-1.8	1.0
Bouts of movement, locomotor time 1	0.9	1.1	2.7	0.1	-0.1	-0.5	0.6	1.6	1.0	-1.0	1.6	-1.6
Total resting periods, locomotor time 1	0.6	0.7	1.6	-0.1	0.1	-0.7	0.6	1.2	0.9	-0.9	1.1	-1.3
Rest time, locomotor task time 1	0.5	0.7	1.9	-0.6	0.6	-0.9	0.4	0.7	0.8	-0.8	1.4	-1.1
Distance moved, locomotor task time 1	0.4	1.2	2.6	0.1	-0.1	0.9	-1.0	-1.4	-1.2	1.2	-1.6	1.2
Vertical activity count, locomotor time 1	0.4	2.9	5.4	0.6	-0.6	1.9	-1.6	-2.0	-1.9	1.9	-2.3	1.6
Time >=10cm from walls, locomotor time 2	1.6	4.5	10.8	-1.5	1.5	0.9	-1.8	-3.3	-1.8	1.9	-2.9	2.4
Bouts of movement, locomotor time 2	0.2	0.6	2.2	-0.3	0.3	-0.1	-0.4	0.9	0.7	-0.6	1.5	-1.1
Total resting periods, locomotor time 2	0.3	1.4	4.0	-0.7	0.7	-0.7	-0.3	1.4	1.2	-1.1	2.0	-1.6
Rest time, locomotor task time 2	0.5	0.8	2.1	-1.4	1.4	-0.7	0.2	0.5	0.7	-0.5	0.8	-0.8
Distance moved, locomotor task time 2	2.5	3.3	7.2	0.9	-0.9	1.5	-0.6	-2.3	-2.0	1.8	-2.7	2.5
Vertical activity count, locomotor time 2	1.4	3.2	7.7	0.4	-0.4	1.4	-0.9	-2.4	-1.9	1.8	-2.8	2.3
Light reinforcement 1	0.6	2.5	5.4	0.4	-0.4	2.0	-1.2	-2.3	-1.6	1.7	-1.9	1.7
Light reinforcement 2	0.8	1.7	3.9	-0.3	0.3	1.4	-0.6	-2.0	-1.3	1.4	-1.7	1.4
Bone: marrow area	2.0	5.0	13.5	-3.7	3.7	0.1	-2.5	-2.3	-1.1	1.4	-1.7	0.8
Bone: maximum diameter	0.8	1.5	5.3	-2.3	2.3	-1.3	-0.1	0.6	0.8	-0.6	0.3	-0.3
Bone: maximum force	1.0	1.9	2.9	-0.1	0.1	1.7	-1.3	-1.7	-1.7	1.7	-1.4	1.6
Bone: maximum moment	0.7	1.3	2.2	-0.2	0.2	1.3	-1.0	-1.5	-1.4	1.3	-1.2	1.3
Mean time between licks in bursts	0.4	2.7	5.2	-2.3	2.3	-2.1	0.3	0.9	1.8	-1.6	1.2	-0.9
Mean num. licks in bursts	0.7	1.8	6.9	2.6	-2.6	1.1	0.2	-0.0	-0.8	0.5	-0.1	0.4
Cd content in liver	2.0	2.2	6.0	1.1	-1.1	1.1	0.2	-1.2	-1.4	1.3	-2.4	2.2
Co content in liver	2.3	2.7	4.2	0.9	-0.9	1.8	-1.1	-2.0	-2.0	1.9	-2.0	1.6
Cu content in liver	1.3	1.5	4.5	2.1	-2.1	0.1	0.9	1.3	0.4	-0.6	1.1	-0.8
Fe content in liver	0.6	0.8	1.6	1.1	-1.1	1.3	-0.4	-0.6	-1.0	0.9	-0.7	0.6
K content in liver	0.7	0.7	2.5	0.2	-0.2	-0.6	1.6	0.6	0.9	-0.9	1.0	-0.4
Mg content in liver	1.5	1.7	2.4	-1.6	1.6	-1.3	1.3	0.9	1.5	-1.3	1.0	-1.1
Mn content in liver	1.5	1.7	6.7	-2.6	2.6	-0.9	0.5	-0.3	0.6	-0.4	-0.3	-0.1
Na content in liver	0.6	0.6	2.1	0.7	-0.7	-0.0	0.2	0.8	0.6	-0.6	1.5	-1.1
Rb content in liver	0.1	0.1	0.5	-0.0	0.0	-0.0	0.7	-0.6	-0.1	0.1	-0.7	0.1
Se content in liver	2.6	3.1	6.7	-2.6	2.6	-2.2	0.4	0.6	1.7	-1.5	1.3	-1.4
Sr content in liver	0.6	0.5	1.3	-0.8	0.8	0.0	-0.1	-0.6	-0.6	0.5	-1.1	1.1
Zn content in liver	0.3	0.4	1.1	-0.7	0.7	-0.2	0.1	-0.7	-0.3	0.3	-0.9	1.1
Bone: minimum diameter	1.0	2.0	7.6	-2.8	2.8	-0.5	-0.8	-0.6	-0.2	0.4	-0.8	0.7
Time in familiar zone, hab. session 1	2.3	2.5	5.1	2.3	-2.3	-0.3	1.7	1.9	0.9	-1.1	1.6	-1.0
Time in novel zone, hab. session 1	1.9	2.2	3.6	-1.8	1.8	0.3	-1.9	-1.8	-0.9	1.1	-1.4	1.3
Total zone transitions, hab. session 1	0.5	0.7	1.5	-0.0	0.0	-0.6	1.2	0.8	1.1	-1.0	1.0	-0.6
Total locomotion distance, hab. session 1	0.5	0.7	1.6	0.0	-0.0	-0.4	1.3	0.7	1.0	-0.9	1.0	-0.8
Locomotion velocity, hab. session 1	0.4	0.6	1.2	-0.1	0.1	-0.4	1.0	0.7	0.9	-0.9	1.1	-1.1
Time in familiar zone, hab. session 2	0.4	0.5	0.9	1.0	-1.0	0.8	-0.3	0.4	0.1	-0.1	0.9	-0.7
Time in novel zone, hab. session 2	0.4	0.4	1.1	-0.3	0.3	-0.4	-0.3	-0.8	-0.6	0.5	-1.0	1.0
Total zone transitions, hab. session 2	0.1	0.1	0.5	0.2	-0.2	0.7	0.5	0.2	0.1	-0.0	0.1	0.0
Total locomotion distance, hab. session 2	0.3	0.4	1.8	0.3	-0.3	0.3	1.3	0.6	0.7	-0.6	0.6	-0.4
Locomotion velocity, hab. session 2	0.6	0.8	2.6	0.1	-0.1	-0.0	1.6	0.9	1.0	-0.9	0.9	-0.8
Novel to familiar place preference ratio	0.1	0.1	0.5	0.0	-0.0	-0.7	0.6	0.1	0.3	-0.4	0.1	-0.4
Novelty place preference	0.1	0.2	0.6	-0.2	0.2	-0.8	0.3	0.2	0.4	-0.4	0.1	-0.5
Time in novel zone, NPP test	0.1	0.2	0.6	-0.4	0.4	-0.8	0.2	0.3	0.3	-0.4	0.2	-0.5
Total zone transitions, NPP test	0.8	1.1	4.6	0.3	-0.3	-0.7	2.1	1.1	1.2	-1.2	0.8	-0.3
Total locomotion distance, NPP test	0.5	0.7	4.4	0.7	-0.7	-0.1	2.1	0.6	0.5	-0.5	-0.1	0.3
Locomotion velocity, NPP test	0.7	1.0	6.4	0.8	-0.8	-0.2	2.5	0.6	0.8	-0.8	0.1	0.2
Intraocular pressure	0.4	0.7	2.2	1.5	-1.5	0.7	0.6	-0.3	-0.2	0.1	-0.6	0.2
Delta distance traveled before/after self-admin	0.3	0.4	2.8	-0.4	0.4	-0.3	-1.7	0.3	-0.2	0.2	0.1	-0.1
Delta ambulatory time before/after self-admin	0.3	0.5	3.0	-0.6	0.6	-0.6	-1.7	0.1	-0.1	0.2	0.0	-0.0
Parametrial fat weight	1.9	4.4	9.1	1.5	-1.5	3.0	-1.2	-2.1	-2.6	2.5	-2.1	1.8
Pavlov. Cond. lever latency	5.1	6.5	12.1	1.7	-1.7	3.5	-2.6	-2.7	-2.9	2.9	-1.9	2.4
Pavlov. Cond. magazine entry latency	3.7	4.8	7.4	-1.6	1.6	-2.7	1.4	2.5	2.4	-2.4	2.2	-2.5
Pavlov. Cond. change in total contacts	1.9	2.1	3.7	-1.4	1.4	-1.9	0.6	1.5	1.5	-1.4	1.2	-1.8
Pavlov. Cond. index score	4.8	6.1	10.1	-2.0	2.0	-3.2	2.1	2.7	2.7	-2.7	2.1	-2.5
Pavlov. Cond. latency score	5.1	6.5	10.9	-2.0	2.0	-3.3	2.1	2.8	2.8	-2.8	2.2	-2.6
Pavlov. Cond. lever contacts	3.5	4.2	7.9	-1.9	1.9	-2.8	2.3	2.0	2.2	-2.2	1.2	-1.7
Pavlov. Cond. magazine entry number	2.6	3.4	5.2	1.4	-1.4	2.3	-1.3	-2.0	-2.1	2.0	-1.8	2.0
Pavlov. Cond. intertrial magazine entries	1.9	2.2	5.3	2.3	-2.3	1.5	0.0	-1.2	-1.2	1.1	-1.3	1.2
Pavlov. Cond. lever-magazine prob. diff.	4.8	6.0	9.8	-2.0	2.0	-3.1	2.2	2.7	2.7	-2.6	2.0	-2.5
Pavlov. Cond. response bias	3.3	4.1	6.7	-1.7	1.7	-2.6	1.8	2.1	2.3	-2.2	1.7	-2.1
Pavlov. Cond. lever latency	0.6	0.9	1.7	-1.1	1.1	0.4	-0.9	-1.1	-0.6	0.7	-1.3	0.8
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	-0.7	0.7	-0.9	0.7	0.5	0.5	-0.6	0.3	-0.1
Pavlov. Cond. change in total contacts	0.3	0.7	2.0	0.5	-0.5	-0.7	0.4	1.1	0.7	-0.8	1.4	-1.2
Pavlov. Cond. index score	0.4	0.6	1.2	0.1	-0.1	-0.8	0.7	1.1	0.7	-0.8	1.1	-0.7
Pavlov. Cond. latency score	0.3	0.4	1.0	0.2	-0.2	-0.6	0.5	1.0	0.5	-0.6	1.0	-0.6
Pavlov. Cond. lever contacts	0.4	0.7	1.3	1.0	-1.0	-0.3	0.8	0.9	0.4	-0.6	1.2	-0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.2	-0.2	0.3	-0.5	-0.2	-0.1	0.2	-0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.5	1.1	2.0	-0.8	0.8	-1.1	-0.0	1.0	1.3	-1.1	1.0	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.5	1.1	0.1	-0.1	-0.7	0.7	1.0	0.6	-0.7	1.0	-0.6
Pavlov. Cond. response bias	0.6	0.8	1.6	0.3	-0.3	-0.8	1.1	1.1	0.8	-1.0	1.3	-0.8
Time in closed arm before self-admin	0.1	0.2	0.4	-0.6	0.6	-0.4	-0.2	-0.2	0.1	-0.1	-0.5	0.4
Time in closed arm after self-admin	0.0	0.1	0.1	-0.3	0.3	0.3	-0.1	-0.3	-0.2	0.2	-0.0	-0.3
Time in open arm before self-admin	1.0	1.2	2.5	-0.2	0.2	-1.3	0.7	0.9	1.2	-1.3	1.6	-1.5
Time in open arm after self-admin	0.5	0.5	1.2	0.1	-0.1	-1.1	0.4	1.1	0.7	-0.8	0.8	-0.6
Bone: periosteal estimation	1.0	2.4	6.8	-2.6	2.6	0.3	-2.0	-1.3	-0.8	1.0	-0.8	0.5
Bone: periosteal perimeter	0.6	1.1	4.5	-2.1	2.1	-0.5	-0.9	-0.3	0.1	0.1	-0.0	0.0
Bone: post-yield work	0.5	0.8	2.4	-1.6	1.6	-0.4	-0.0	-0.9	-0.1	0.2	-0.8	0.9
Progressive ratio test 1 active lever presses	0.1	0.2	0.6	0.1	-0.1	0.2	0.7	-0.5	-0.1	0.0	-0.8	-0.0
Progressive ratio test 1 breakpoint	0.1	0.2	0.7	0.0	-0.0	0.1	0.6	-0.5	-0.1	0.0	-0.8	0.0
Progressive ratio test 1 inactive lever presses	0.3	0.7	1.5	1.0	-1.0	1.2	0.4	-0.3	-0.7	0.6	-1.1	0.6
Progressive ratio test 2 active lever presses	0.3	0.4	1.3	0.7	-0.7	-0.2	1.2	0.6	0.5	-0.6	0.3	-0.6
Progressive ratio test 2 breakpoint	0.4	0.5	1.4	0.8	-0.8	-0.2	1.2	0.7	0.5	-0.6	0.4	-0.7
Progressive ratio test 2 inactive lever presses	0.1	0.4	1.3	-0.5	0.5	-0.8	1.1	0.0	0.5	-0.5	-0.6	0.0
Incentive Sensitization - Responses	0.4	1.1	2.0	0.3	-0.3	-0.8	1.0	1.4	1.1	-1.0	1.3	-1.3
Incentive Sensitization - Breakpoint	0.5	1.1	2.1	0.5	-0.5	-0.7	1.1	1.5	1.0	-1.0	1.3	-1.3
Sum of active levers in priming session hrs 5-6	0.5	0.4	1.3	-0.6	0.6	-1.2	0.4	0.1	0.7	-0.7	0.5	-0.7
Progressive ratio	1.2	3.5	9.5	0.5	-0.5	2.6	-3.1	-1.8	-2.3	2.3	-0.8	0.5
Food seeking constrained by brief footshock	0.1	0.1	0.5	0.7	-0.7	0.1	0.2	-0.4	-0.1	-0.1	0.3	0.1
Seeking ratio, punishment vs. effort	1.1	2.4	5.5	-0.4	0.4	-2.3	2.2	1.2	2.0	-2.1	1.0	-0.5
Retroperitoneal fat weight	0.2	0.8	1.6	0.6	-0.6	1.3	-0.0	-0.6	-1.1	1.1	-1.2	0.7
Reaction time number correct	0.4	1.2	2.1	1.5	-1.5	1.4	-1.0	-0.8	-1.1	1.1	-0.5	0.7
Reaction time mean minus median	0.3	1.8	4.7	-1.1	1.1	-2.2	1.4	1.1	1.6	-1.5	0.6	-0.9
Reaction time mean minus median AUC	0.3	1.9	5.9	-0.9	0.9	-2.4	2.0	0.8	1.5	-1.6	0.2	-0.6
Reaction time num false alarms	0.5	0.8	1.6	-1.3	1.3	-0.4	-0.5	0.3	0.7	-0.6	0.9	-1.2
Reaction time num false alarms AUC	0.5	1.1	2.0	-1.4	1.4	-0.4	-0.9	0.4	0.8	-0.6	1.2	-1.4
Reaction time trials correct on left	0.4	1.2	2.1	1.5	-1.5	1.4	-1.0	-0.8	-1.1	1.1	-0.5	0.7
Reaction time trials on left	0.3	1.2	1.9	1.4	-1.4	1.3	-1.0	-0.8	-1.1	1.1	-0.5	0.7
Reaction time mean	0.6	1.4	3.1	-1.6	1.6	-1.8	1.4	0.4	0.9	-0.8	-0.6	-0.0
Reaction time mean AUC	0.5	1.2	2.8	-1.5	1.5	-1.7	1.5	0.4	0.8	-0.8	-0.5	-0.0
Median of all reaction times	0.6	0.9	2.0	-1.4	1.4	-1.2	1.1	0.1	0.4	-0.3	-0.9	0.3
Reaction time omissions	0.5	0.8	1.7	-1.3	1.3	-1.1	1.1	0.5	1.0	-0.8	0.0	0.1
Reaction time false alarm rate	1.7	2.3	4.7	-2.2	2.2	-1.4	-0.2	0.9	1.5	-1.3	1.4	-1.8
Reaction time premature initiation rate	0.3	0.4	1.5	-0.0	0.0	0.2	-0.4	-0.7	-0.6	0.6	-0.9	1.2
Reaction time premature initiations	0.5	1.5	2.5	0.8	-0.8	1.1	-1.2	-1.3	-1.4	1.3	-1.2	1.6
Std. dev. reaction times	0.7	2.4	6.1	-1.9	1.9	-2.5	1.2	1.1	1.6	-1.5	0.5	-0.9
Reaction time trials completed	0.3	1.2	1.9	1.4	-1.4	1.3	-1.0	-0.8	-1.1	1.1	-0.5	0.7
Reaction time trials AUC	0.4	1.2	1.9	1.4	-1.4	1.4	-1.0	-0.9	-1.2	1.1	-0.6	0.9
Run reversals in cocaine runway, females	0.4	0.5	1.1	1.0	-1.0	1.0	0.2	-0.3	-0.7	0.5	-0.6	0.5
Run reversals in cocaine runway, males	0.5	0.5	1.0	-0.7	0.7	-0.7	0.8	0.5	1.0	-0.9	0.7	-0.1
Latency to leave start box in cocaine runway	0.3	0.5	1.2	-1.1	1.1	-1.1	0.5	0.3	0.5	-0.4	-0.2	0.0
Latency to leave start box in cocaine runway, F	0.2	0.3	0.6	-0.7	0.7	-0.8	0.5	-0.0	0.5	-0.5	-0.3	-0.1
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	-0.7	0.7	-0.3	-0.1	0.2	-0.1	0.1	-0.1	0.5
Std. dev. time between licks in bursts	1.6	3.0	9.1	-3.0	3.0	-1.8	-0.4	1.0	1.4	-1.1	0.8	-0.9
Total sessions with >9 infusions	0.1	0.1	0.5	0.4	-0.4	0.1	0.3	-0.2	0.1	-0.3	0.0	-0.7
Short access day 1 total inactive lever presses	0.2	0.4	0.9	-0.9	0.9	-0.9	0.7	-0.5	0.3	-0.4	-0.3	-0.1
Short access day 10 total inactive lever presses	0.0	0.3	0.8	-0.4	0.4	0.2	0.3	0.6	0.6	-0.4	0.8	-0.9
Short access day 1 total infusions	0.1	0.2	0.8	-0.0	0.0	-0.9	0.8	-0.3	0.3	-0.5	-0.4	-0.4
Short access day 10 total infusions	0.2	0.4	1.2	0.8	-0.8	0.3	1.1	0.2	0.2	-0.3	0.0	-0.9
Short access total infusions	0.1	0.2	0.8	0.5	-0.5	-0.2	0.9	-0.2	0.1	-0.3	-0.4	-0.5
Short access day 1 locomotion	0.3	0.5	1.8	-0.1	0.1	-0.3	0.9	0.5	0.8	-0.8	0.5	-1.3
Short access day 10 total locomotion	0.5	2.1	5.8	-1.8	1.8	1.3	-2.4	-1.6	-0.7	1.0	-0.6	1.0
Short access total locomotion	0.4	0.6	1.2	-1.0	1.0	0.5	-0.7	-1.1	-0.4	0.4	-0.9	0.5
One hour access (0.3 mA shock)	1.3	1.5	2.7	0.4	-0.4	-0.4	1.6	1.6	1.3	-1.3	1.4	-1.6
Compulsive drug intake	0.5	0.8	2.5	-1.6	1.6	-0.3	0.3	0.4	1.0	-0.7	0.6	0.1
One hour access (shock baseline)	0.3	0.9	2.6	1.6	-1.6	-0.2	1.0	0.7	0.1	-0.4	0.4	-1.0
Social response proportion	0.6	0.7	2.0	-1.2	1.2	0.4	-1.4	-0.7	-0.6	0.7	-0.5	-0.2
Social responses	0.4	0.5	2.0	-0.8	0.8	0.4	-1.4	-0.6	-0.3	0.4	0.1	-0.8
Social time	1.0	1.6	4.3	-2.1	2.1	-0.7	-0.1	0.3	1.4	-1.0	1.1	-1.3
Soleus weight	1.7	5.0	18.8	-4.3	4.3	-0.9	-1.3	-1.6	-0.1	0.4	-1.2	0.9
Bone: stiffness	0.8	1.4	3.0	0.4	-0.4	1.7	-0.9	-1.5	-1.3	1.3	-1.1	1.1
Tibialis anterior weight	0.2	0.8	2.3	1.5	-1.5	1.5	-0.2	-0.4	-0.6	0.6	0.1	-0.4
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.8	0.4	-0.4	0.9	0.0	0.5	0.1	0.0	0.7	0.4
Time to tail flick, vehicle, after self-admin	0.1	0.3	0.6	-0.6	0.6	-0.8	0.4	0.3	0.6	-0.6	0.2	-0.1
Time to tail flick, test, before self-admin	0.7	0.8	3.0	0.7	-0.7	0.2	-0.2	1.1	0.7	-0.6	1.7	-1.1
Time to tail flick, test, after self-admin	2.8	3.0	5.4	0.6	-0.6	-1.4	1.7	2.3	1.9	-1.9	2.2	-2.0
Delta time to tail flick, vehicle, before/after SA	0.6	0.7	1.9	0.3	-0.3	-1.3	1.4	0.6	0.7	-0.9	0.3	-0.7
Delta time to tail flick, test, before/after SA	0.3	0.3	1.8	0.5	-0.5	-0.3	1.4	0.5	0.3	-0.4	-0.1	-0.2
Tibia length	1.2	3.5	9.5	-3.1	3.1	0.6	-2.0	-2.0	-0.9	1.2	-1.0	0.3
Ambulatory time before self-admin	0.0	0.1	0.3	-0.1	0.1	0.5	0.4	-0.3	-0.0	0.1	0.1	-0.3
Ambulatory time after self-admin	0.3	0.4	2.0	-0.7	0.7	0.3	-1.4	-0.3	-0.4	0.6	-0.2	-0.2
Bone: tissue strength	0.6	0.6	1.4	0.3	-0.3	0.4	-0.1	-1.0	-0.8	0.7	-1.2	1.1
Total heroin consumption	0.2	0.3	1.2	-0.4	0.4	-0.2	-0.2	0.4	0.5	-0.3	0.5	-1.1
Bone: trabecular number	1.2	2.3	4.7	2.2	-2.2	-0.3	2.2	1.8	1.0	-1.2	0.8	-0.6
Bone: trabecular spacing	1.6	2.3	4.8	-1.8	1.8	0.5	-2.2	-1.9	-1.3	1.4	-1.1	0.8
Bone: trabecular thickness	0.8	1.1	2.9	1.7	-1.7	0.3	1.7	1.0	0.4	-0.5	0.2	0.2
Bone: trabecular tissue density	0.3	0.6	1.6	-0.6	0.6	-1.1	-0.1	0.1	0.7	-0.7	0.9	-1.3
Water consumed over 24 hours	0.1	0.2	0.8	-0.9	0.9	-0.3	-0.0	-0.0	0.1	-0.0	-0.0	0.1
Number of responses in last shaping day	1.1	1.4	4.3	-2.1	2.1	-1.5	-1.1	-0.6	0.2	-0.2	-0.3	-0.1