Rtn2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Rtn2 0.08 0.07 8.8e-04 0.03 0.03 0.04 0.04 1.7e-02 1.8e-02 3.5e-03 4.3e-03
2 Adipose alternative TSS NM_201562.3 0.03 0.03 2.5e-04 0.03 0.03 0.03 0.03 4.1e-04 2.4e-04 4.9e-04 4.8e-04
3 Adipose alternative TSS XM_017589116.3 0.04 0.03 2.3e-04 0.03 0.03 0.03 0.03 3.9e-04 2.3e-04 4.2e-04 4.8e-04
4 Adipose isoform ratio XM_017589116.3 0.02 0.02 2.8e-03 0.02 0.02 0.01 0.01 5.5e-03 4.2e-03 1.1e-02 8.9e-03
5 IL alternative polyA XM_017589116.3 0.15 0.13 4.3e-03 0.09 0.1 0.09 0.09 2.9e-03 2.3e-03 3.6e-03 4.5e-03
6 IL alternative polyA NM_201562.3 0.15 0.14 4.0e-03 0.09 0.1 0.09 0.09 3.1e-03 2.3e-03 3.8e-03 4.6e-03
7 PL gene expression Rtn2 0.11 0.09 3.3e-12 0.11 0.11 0.11 0.11 1.3e-11 5.1e-12 4.9e-12 4.8e-12
8 NAcc gene expression Rtn2 0.07 0.07 3.0e-08 0.05 0.04 0.04 0.04 1.2e-07 2.5e-07 2.0e-07 2.6e-07
9 Brain gene expression Rtn2 0.08 0.07 1.2e-06 0.06 0.06 0.06 0.06 1.2e-06 7.4e-06 6.6e-06 3.9e-06
10 pVTA alternative polyA NM_201562.3 0.05 0.05 4.3e-03 0.03 0.02 0.03 0.02 3.7e-03 1.1e-02 3.7e-03 5.0e-03
11 pVTA alternative polyA XM_017589116.3 0.05 0.06 4.6e-03 0.03 0.02 0.02 0.02 4.2e-03 1.1e-02 4.4e-03 6.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.00.00.00.20.0-0.0-0.0-0.00.00.1-0.10.10.00.0
Area under the delay curve1.51.82.7-1.61.4-1.4-1.41.4-1.4-1.5-1.3-1.60.00.0
BMI with tail0.61.95.52.3-1.31.31.4-1.41.41.41.41.50.00.0
BMI without tail0.51.42.30.5-1.41.41.4-1.41.41.41.51.30.00.0
Body weight0.94.05.22.3-2.22.22.2-2.22.22.22.22.20.00.0
Weight adjusted by age0.00.00.2-0.5-0.00.00.0-0.00.00.00.0-0.00.00.0
Bone surface0.20.41.31.1-0.70.70.6-0.70.70.70.50.80.00.0
Bone volume0.20.30.50.7-0.50.50.5-0.60.60.60.40.70.00.0
Breakpoint value in progressive ratio session1.72.12.7-1.31.6-1.6-1.61.6-1.6-1.6-1.6-1.60.00.0
Number of licking bursts1.72.84.41.6-1.91.91.9-1.91.91.82.11.50.00.0
Context. condit. distance diff. score0.10.20.40.7-0.40.40.4-0.40.40.40.40.40.00.0
Locomotion velocity, session 10.10.10.50.70.2-0.2-0.20.2-0.2-0.3-0.1-0.40.00.0
Locomotion distance, session 10.00.10.30.5-0.20.20.2-0.20.20.3-0.00.40.00.0
Locomotion velocity, session 21.01.21.81.2-1.21.21.2-1.21.21.21.41.00.00.0
Locomotion distance, session 20.30.40.80.9-0.60.60.6-0.70.70.70.40.90.00.0
Locomotion velocity, session 30.20.20.3-0.1-0.50.50.5-0.50.50.50.50.50.00.0
Locomotion distance, session 30.70.71.4-1.20.9-0.9-0.90.9-0.9-0.9-1.0-0.80.00.0
Stereotopy head waving bouts, day 30.60.71.5-0.1-1.01.01.0-1.01.00.91.20.70.00.0
Stereotopy head waving duration, day 30.80.91.50.3-1.11.11.1-1.11.11.11.21.00.00.0
Locomotion velocity, session 70.10.10.20.20.4-0.4-0.40.3-0.3-0.2-0.5-0.10.00.0
Locomotion distance, session 70.00.00.20.4-0.20.20.2-0.20.20.3-0.10.30.00.0
Stereotopy head waving bouts, day 70.81.01.81.1-1.11.11.1-1.01.01.01.31.00.00.0
Stereotopy head waving duration, day 70.60.71.50.7-1.01.01.0-1.01.00.91.20.80.00.0
Locomotion velocity, session 80.00.00.1-0.20.1-0.1-0.10.1-0.1-0.1-0.0-0.10.00.0
Locomotion distance, session 80.00.10.40.6-0.10.10.1-0.20.20.20.00.40.00.0
Degree of sensitization distance0.50.50.70.8-0.80.80.8-0.80.80.80.60.80.00.0
Degree of sensitization stereotypy0.91.01.71.2-1.11.11.1-1.11.11.01.31.00.00.0
Conditioned locomotion0.00.10.2-0.40.2-0.2-0.20.2-0.2-0.2-0.3-0.10.00.0
Cocaine response after cond. corrected0.60.82.51.6-0.80.80.8-0.90.90.80.81.00.00.0
Cocaine response after cond. not corrected1.61.96.42.5-1.31.31.3-1.31.41.31.31.50.00.0
Cocaine response before conditioning1.21.52.01.2-1.41.41.4-1.41.41.41.31.30.00.0
Saline control response1.52.02.80.6-1.71.71.7-1.71.71.71.71.60.00.0
Bone: connectivity density0.00.00.1-0.10.2-0.2-0.20.1-0.1-0.1-0.30.10.00.0
Bone: cortical apparent density0.10.11.0-1.00.3-0.3-0.30.3-0.3-0.2-0.1-0.10.00.0
Bone: cortical area1.21.82.41.0-1.61.61.6-1.61.61.61.51.30.00.0
Bone: cortical porosity0.20.20.5-0.60.4-0.4-0.40.5-0.5-0.5-0.3-0.70.00.0
Bone: cortical porosity0.00.00.1-0.40.1-0.1-0.00.1-0.1-0.10.1-0.20.00.0
Bone: cortical thickness0.40.71.10.1-1.01.01.0-1.01.01.00.90.90.00.0
Bone: cortical thickness1.21.41.91.1-1.31.31.3-1.31.31.41.31.20.00.0
Bone: cortical tissue density0.20.21.2-1.10.4-0.4-0.40.4-0.4-0.3-0.3-0.20.00.0
Condit. Reinf. active minus inactive responses0.60.73.51.9-0.60.60.6-0.70.70.70.80.80.00.0
Condit. Reinf. active-inactive response ratio0.60.63.61.9-0.60.60.5-0.60.60.60.70.80.00.0
Condit. Reinf. active responses0.30.41.81.3-0.50.50.5-0.60.60.60.60.80.00.0
Condit. Reinf. inactive responses0.00.00.2-0.50.2-0.2-0.20.1-0.1-0.0-0.40.20.00.0
Incentive salience index mean0.40.42.41.5-0.50.50.5-0.50.50.50.60.60.00.0
Condit. Reinf. lever presses0.10.10.70.8-0.10.10.1-0.10.10.10.20.20.00.0
Condit. Reinf. active minus inactive responses0.10.10.50.7-0.30.30.3-0.30.30.40.30.40.00.0
Condit. Reinf. active-inactive response ratio0.50.62.41.6-0.70.70.7-0.70.70.80.70.90.00.0
Condit. Reinf. active responses0.10.21.2-1.10.3-0.3-0.30.3-0.3-0.3-0.2-0.30.00.0
Condit. Reinf. inactive responses1.01.37.0-2.61.0-1.0-1.01.0-1.0-0.9-0.9-1.00.00.0
Condit. Reinf. lever presses0.10.10.20.4-0.40.40.4-0.40.40.50.40.40.00.0
Condit. Reinf. lever reinforcers received0.10.21.0-1.00.4-0.4-0.30.3-0.3-0.3-0.3-0.40.00.0
Conditioned reinforcement - actives1.11.82.51.6-1.51.51.5-1.51.51.51.41.50.00.0
Conditioned reinforcement - inactives0.30.40.70.1-0.70.70.8-0.70.70.70.80.70.00.0
Conditioned locomotion2.02.53.61.9-1.71.71.7-1.81.81.81.71.70.00.0
Patch foraging indifference point 0 sec0.30.50.8-0.1-0.90.90.9-0.90.90.80.90.80.00.0
Patch foraging indifference point AUC2.13.14.30.7-2.12.12.1-2.02.02.12.11.90.00.0
Delay disc. indifference point, 0s delay1.11.31.7-1.31.2-1.2-1.21.2-1.2-1.3-1.2-1.30.00.0
Delay disc. indifference point, 16s delay0.91.01.6-0.61.1-1.1-1.11.1-1.1-1.2-1.0-1.20.00.0
Delay disc. indifference point, 2s delay3.23.65.7-2.32.0-2.0-2.02.1-2.1-2.2-1.8-2.40.00.0
Delay disc. indifference point, 24s delay0.10.11.11.1-0.20.20.2-0.30.30.30.00.30.00.0
Delay disc. indifference point, 4s delay0.10.10.6-0.80.1-0.1-0.10.1-0.1-0.1-0.0-0.20.00.0
Delay disc. indifference point, 8s delay1.51.82.9-1.71.4-1.4-1.41.4-1.4-1.5-1.3-1.60.00.0
Indifference point function ln k0.61.01.4-0.71.1-1.1-1.11.1-1.1-1.2-1.2-1.00.00.0
Indifference point function log k0.61.01.4-0.71.1-1.1-1.11.1-1.1-1.2-1.2-1.00.00.0
Patch foraging total patch changes 0 sec0.50.91.20.1-1.11.11.1-1.11.11.11.11.10.00.0
Patch foraging total patch changes 12 sec1.01.31.81.0-1.31.31.3-1.31.31.21.31.20.00.0
Patch foraging total patch changes 18 sec1.52.33.21.2-1.71.71.7-1.71.71.71.61.80.00.0
Patch foraging total patch changes 24 sec0.20.40.60.3-0.70.70.7-0.70.70.60.60.80.00.0
Patch foraging total patch changes 6 sec1.82.73.9-0.2-1.91.91.9-1.91.92.01.91.90.00.0
Patch foraging time to switch 0 sec2.04.26.6-1.32.3-2.3-2.32.4-2.4-2.4-2.1-2.60.00.0
Patch foraging water rate 0 sec2.34.86.61.6-2.52.52.5-2.52.52.52.42.60.00.0
Patch foraging water rate 12 sec0.10.20.50.4-0.50.50.5-0.60.60.60.40.70.00.0
Patch foraging water rate 18 sec0.10.20.3-0.4-0.50.50.4-0.50.50.50.30.60.00.0
Patch foraging water rate 24 sec0.40.61.00.1-0.90.90.9-0.90.90.90.81.00.00.0
Patch foraging water rate 6 sec0.60.81.40.9-1.01.01.0-1.01.01.10.91.20.00.0
Seeking ratio, delayed vs. immediate footshock1.61.93.0-1.71.5-1.5-1.51.5-1.5-1.5-1.5-1.40.00.0
Distance traveled before self-admin0.00.10.1-0.1-0.30.30.3-0.30.30.30.30.20.00.0
Distance traveled after self-admin0.10.10.2-0.40.4-0.4-0.40.4-0.4-0.4-0.5-0.50.00.0
Extensor digitorum longus weight1.55.910.33.2-2.72.72.7-2.72.72.52.62.40.00.0
Bone: elastic displacement0.70.81.3-0.31.1-1.1-1.11.1-1.1-1.1-0.9-1.00.00.0
Bone: elastic work0.00.00.00.1-0.10.10.1-0.10.10.10.20.10.00.0
Bone: endosteal estimation0.10.22.31.50.2-0.2-0.20.2-0.2-0.2-0.3-0.20.00.0
Bone: endosteal perimeter0.10.11.31.10.0-0.0-0.00.0-0.0-0.0-0.0-0.10.00.0
Epididymis fat weight0.20.71.2-1.10.9-0.9-0.90.9-0.9-0.9-0.8-1.00.00.0
Delta time in closed arm before/after self-admin0.10.10.10.30.3-0.3-0.30.3-0.3-0.3-0.3-0.10.00.0
Delta time in open arm before/after self-admin0.20.21.8-1.30.2-0.2-0.20.2-0.2-0.1-0.2-0.20.00.0
Diff in mean of infusions in LGA sessions1.11.31.8-1.21.3-1.3-1.31.3-1.3-1.3-1.3-1.30.00.0
Delay discount exponential model param1.11.32.01.3-1.21.21.2-1.21.21.31.11.40.00.0
Extinction: sum of active levers before priming0.00.00.1-0.10.2-0.2-0.20.2-0.2-0.2-0.2-0.20.00.0
Active lever presses in extinction session 60.10.10.10.2-0.30.30.3-0.20.20.30.20.20.00.0
Bone: final force0.20.40.60.3-0.80.80.8-0.80.80.70.70.60.00.0
Bone: final moment0.40.60.90.6-0.90.90.9-0.90.90.90.90.70.00.0
Food consumed during 24 hour testing period4.05.57.5-2.52.6-2.6-2.62.6-2.6-2.6-2.7-2.40.00.0
Glucose0.20.30.6-0.20.7-0.6-0.60.7-0.7-0.7-0.5-0.80.00.0
Heart weight1.72.63.51.3-1.91.91.9-1.81.81.91.81.70.00.0
Delay discount hyperbolic model param1.11.21.91.4-1.11.11.1-1.21.21.21.01.40.00.0
Intermittent access intake day 1-15 change0.10.10.2-0.0-0.40.40.4-0.40.40.40.30.40.00.0
Intermittent access intake escalation0.10.20.20.0-0.50.50.5-0.50.50.50.40.50.00.0
Intermittent access intake escalation 20.00.00.0-0.2-0.10.10.1-0.10.10.10.00.10.00.0
Intermitt. access day 1 inactive lever presses0.00.00.10.4-0.10.10.1-0.10.10.00.00.00.00.0
Intermitt. access day 15 inactive lever presses0.00.00.0-0.2-0.00.00.0-0.00.00.00.10.00.00.0
Intermitt. access escalation Index0.10.20.3-0.00.5-0.5-0.50.5-0.5-0.6-0.5-0.50.00.0
Intermittent access day 1 total infusions1.11.72.40.5-1.51.51.5-1.51.51.51.61.50.00.0
Intermittent access day 15 total infusions0.50.81.10.3-1.01.01.0-1.01.01.11.01.00.00.0
Intermittent access terminal intake (last 3 days)0.81.11.60.5-1.21.21.2-1.21.21.31.21.20.00.0
Intermittent access total infusions1.92.23.01.1-1.71.71.7-1.71.71.71.71.70.00.0
Intermittent access day 1 locomotion0.30.30.70.8-0.60.60.6-0.60.60.60.60.60.00.0
Intermittent access day 15 total locomotion0.10.20.2-0.1-0.50.50.5-0.50.50.50.50.50.00.0
Intermittent access total locomotion1.21.52.00.8-1.41.41.4-1.41.41.41.41.40.00.0
Intermittent access standard deviation0.10.20.6-0.80.5-0.5-0.50.5-0.5-0.5-0.4-0.50.00.0
Left kidney weight4.520.928.94.4-5.15.15.1-5.15.15.24.95.40.00.0
Right kidney weight4.219.125.44.6-4.94.94.8-4.94.94.94.65.00.00.0
Cocaine induced anxiety0.30.42.4-1.60.5-0.5-0.50.5-0.5-0.6-0.4-0.60.00.0
Post-drug Anxiety0.10.11.0-1.00.2-0.2-0.20.2-0.2-0.3-0.1-0.30.00.0
Baseline Anxiety0.00.00.20.4-0.00.00.0-0.00.00.00.00.00.00.0
Tail length0.20.91.5-0.2-1.11.11.2-1.11.11.11.21.00.00.0
Length with tail0.21.01.4-0.0-1.21.21.2-1.21.21.11.11.10.00.0
Length without tail0.31.13.01.7-1.11.11.1-1.11.11.00.91.20.00.0
Times rat made contact with spout0.10.10.80.90.0-0.0-0.10.0-0.00.0-0.10.20.00.0
Lifetime Intake1.82.12.90.8-1.71.71.7-1.71.71.71.71.70.00.0
Liver weight, left1.52.63.81.2-1.91.91.9-1.81.81.81.91.60.00.0
Liver weight, right1.01.72.50.8-1.51.51.5-1.51.51.51.51.60.00.0
Locomotor activity1.62.53.6-0.7-1.91.91.9-1.81.81.91.91.70.00.0
Locomotor testing distance0.91.72.2-1.5-1.51.51.5-1.41.41.41.51.30.00.0
Locomotor testing rearing3.36.69.01.5-3.03.03.0-2.92.92.93.02.90.00.0
Locomotion in novel chamber0.10.10.30.00.4-0.4-0.40.4-0.4-0.3-0.5-0.40.00.0
Locomotion in novel chamber post-restriction0.71.12.1-1.41.1-1.1-1.11.1-1.1-1.2-1.1-1.10.00.0
Fecal boli incidents, locomotor time 10.00.00.10.4-0.20.20.2-0.20.20.20.30.10.00.0
Change in fecal boli incidents, locomotor task1.01.04.0-2.00.9-0.9-0.90.9-0.9-1.0-1.0-1.10.00.0
Time >=10cm from walls, locomotor time 10.00.00.20.40.0-0.0-0.0-0.00.00.1-0.10.30.00.0
Bouts of movement, locomotor time 11.82.03.0-1.31.6-1.6-1.61.6-1.6-1.6-1.7-1.50.00.0
Total resting periods, locomotor time 12.52.83.9-2.01.9-1.9-1.91.8-1.8-1.8-2.0-1.70.00.0
Rest time, locomotor task time 10.10.20.3-0.60.5-0.5-0.50.4-0.4-0.4-0.6-0.30.00.0
Distance moved, locomotor task time 10.30.40.60.8-0.70.70.7-0.70.70.60.80.50.00.0
Vertical activity count, locomotor time 10.00.00.2-0.50.1-0.1-0.10.1-0.1-0.2-0.0-0.30.00.0
Time >=10cm from walls, locomotor time 20.10.10.20.20.3-0.3-0.30.3-0.3-0.3-0.2-0.40.00.0
Bouts of movement, locomotor time 23.25.17.3-0.82.7-2.7-2.72.6-2.6-2.6-2.7-2.50.00.0
Total resting periods, locomotor time 22.54.46.5-0.62.5-2.5-2.52.5-2.5-2.4-2.5-2.30.00.0
Rest time, locomotor task time 20.10.11.1-1.00.2-0.2-0.20.1-0.1-0.1-0.20.10.00.0
Distance moved, locomotor task time 20.91.05.12.3-0.90.90.9-0.90.90.81.00.60.00.0
Vertical activity count, locomotor time 20.10.10.40.30.3-0.3-0.30.4-0.4-0.5-0.3-0.60.00.0
Light reinforcement 10.00.10.2-0.0-0.40.40.4-0.40.40.50.30.40.00.0
Light reinforcement 20.00.10.2-0.1-0.30.30.3-0.30.30.40.20.30.00.0
Bone: marrow area0.10.32.71.60.2-0.2-0.20.2-0.2-0.2-0.2-0.20.00.0
Bone: maximum diameter2.13.89.43.1-2.02.02.0-2.02.12.02.02.00.00.0
Bone: maximum force0.10.20.3-0.3-0.50.50.5-0.50.50.50.40.30.00.0
Bone: maximum moment0.10.20.40.0-0.60.60.6-0.60.60.60.50.40.00.0
Mean time between licks in bursts0.10.10.7-0.80.3-0.3-0.30.3-0.3-0.3-0.3-0.40.00.0
Mean num. licks in bursts1.62.64.6-1.01.9-1.9-1.91.9-1.8-1.7-2.2-1.30.00.0
Cd content in liver0.30.43.71.90.2-0.2-0.20.1-0.1-0.2-0.30.10.00.0
Co content in liver0.91.11.7-0.01.2-1.2-1.21.2-1.2-1.3-1.2-1.20.00.0
Cu content in liver0.20.30.50.7-0.60.60.6-0.60.60.50.60.50.00.0
Fe content in liver3.54.26.61.0-2.42.42.5-2.42.42.32.61.90.00.0
K content in liver0.10.10.1-0.2-0.40.40.3-0.30.30.20.40.20.00.0
Mg content in liver0.30.30.60.3-0.70.70.7-0.70.70.60.80.60.00.0
Mn content in liver0.70.81.10.7-1.01.01.0-1.01.01.01.01.10.00.0
Na content in liver0.10.10.2-0.5-0.50.50.5-0.40.40.30.40.10.00.0
Rb content in liver0.20.21.31.1-0.30.30.3-0.40.40.30.20.60.00.0
Se content in liver2.53.04.80.1-2.12.12.1-2.02.02.02.21.70.00.0
Sr content in liver0.10.00.3-0.6-0.10.10.1-0.10.10.20.2-0.10.00.0
Zn content in liver1.01.15.72.4-0.90.90.9-0.90.90.80.90.80.00.0
Bone: minimum diameter0.10.20.30.4-0.60.60.6-0.60.60.50.50.40.00.0
Time in familiar zone, hab. session 10.20.10.30.5-0.40.40.4-0.40.40.40.40.30.00.0
Time in novel zone, hab. session 10.40.40.60.7-0.70.70.7-0.70.70.70.80.70.00.0
Total zone transitions, hab. session 10.20.20.50.4-0.50.50.5-0.50.50.60.40.70.00.0
Total locomotion distance, hab. session 10.40.51.4-1.20.7-0.7-0.70.7-0.7-0.8-0.7-0.80.00.0
Locomotion velocity, hab. session 11.11.63.5-1.91.3-1.3-1.31.3-1.3-1.3-1.3-1.30.00.0
Time in familiar zone, hab. session 20.20.20.5-0.2-0.50.50.5-0.50.50.40.70.30.00.0
Time in novel zone, hab. session 20.10.10.70.80.2-0.2-0.20.2-0.2-0.2-0.3-0.10.00.0
Total zone transitions, hab. session 20.40.50.70.6-0.80.80.8-0.80.80.80.80.60.00.0
Total locomotion distance, hab. session 20.40.61.0-0.50.8-0.8-0.80.9-0.9-0.9-0.7-1.00.00.0
Locomotion velocity, hab. session 20.30.40.6-0.70.7-0.7-0.70.7-0.7-0.7-0.6-0.80.00.0
Novel to familiar place preference ratio0.91.03.71.9-0.90.90.9-0.90.91.00.51.30.00.0
Novelty place preference0.80.93.41.8-0.80.80.8-0.90.91.00.51.20.00.0
Time in novel zone, NPP test1.01.13.81.9-0.90.90.9-1.01.01.10.61.30.00.0
Total zone transitions, NPP test0.10.10.20.1-0.40.40.4-0.40.40.40.30.40.00.0
Total locomotion distance, NPP test0.10.10.40.6-0.40.40.4-0.40.40.40.30.40.00.0
Locomotion velocity, NPP test0.10.10.50.7-0.30.30.3-0.30.30.30.20.40.00.0
Intraocular pressure0.10.10.90.90.1-0.1-0.10.0-0.0-0.10.1-0.10.00.0
Delta distance traveled before/after self-admin1.51.62.0-1.11.4-1.4-1.41.4-1.4-1.3-1.4-1.40.00.0
Delta ambulatory time before/after self-admin0.30.40.5-0.60.7-0.7-0.70.7-0.7-0.6-0.7-0.70.00.0
Parametrial fat weight0.00.10.20.4-0.40.40.4-0.40.40.40.30.50.00.0
Pavlov. Cond. lever latency0.60.72.7-1.60.8-0.8-0.80.8-0.8-0.8-0.9-0.80.00.0
Pavlov. Cond. magazine entry latency0.20.21.51.2-0.30.30.3-0.30.30.20.40.30.00.0
Pavlov. Cond. change in total contacts0.40.50.70.80.8-0.8-0.80.8-0.8-0.8-0.7-0.60.00.0
Pavlov. Cond. index score0.40.52.51.6-0.50.50.5-0.60.60.50.70.60.00.0
Pavlov. Cond. latency score0.20.21.71.3-0.20.20.2-0.20.20.20.40.20.00.0
Pavlov. Cond. lever contacts0.40.52.41.5-0.60.60.6-0.60.60.50.70.60.00.0
Pavlov. Cond. magazine entry number0.10.21.8-1.30.1-0.1-0.10.1-0.1-0.0-0.3-0.10.00.0
Pavlov. Cond. intertrial magazine entries0.10.10.50.7-0.30.30.3-0.30.30.40.20.50.00.0
Pavlov. Cond. lever-magazine prob. diff.0.40.52.21.5-0.60.60.6-0.60.60.50.80.60.00.0
Pavlov. Cond. response bias1.01.24.42.1-1.01.01.0-1.01.01.01.21.10.00.0
Pavlov. Cond. lever latency0.00.00.3-0.50.1-0.1-0.10.1-0.1-0.1-0.1-0.00.00.0
Pavlov. Cond. magazine entry latency0.60.77.72.8-0.20.20.1-0.20.20.20.00.50.00.0
Pavlov. Cond. change in total contacts0.10.20.70.80.5-0.5-0.50.4-0.4-0.4-0.6-0.40.00.0
Pavlov. Cond. index score0.20.22.21.50.1-0.1-0.10.1-0.1-0.1-0.20.10.00.0
Pavlov. Cond. latency score0.10.21.51.20.2-0.2-0.20.2-0.2-0.2-0.3-0.10.00.0
Pavlov. Cond. lever contacts0.10.10.80.9-0.30.30.3-0.30.30.30.30.30.00.0
Pavlov. Cond. magazine entry number0.50.64.1-2.0-0.60.60.6-0.50.50.50.70.30.00.0
Pavlov. Cond. intertrial magazine entries0.20.43.9-2.0-0.10.10.1-0.00.00.10.10.10.00.0
Pavlov. Cond. lever-magazine prob. diff.0.20.22.41.5-0.10.10.1-0.10.10.1-0.00.20.00.0
Pavlov. Cond. response bias0.20.22.31.50.0-0.0-0.0-0.00.00.0-0.10.10.00.0
Time in closed arm before self-admin0.60.81.10.4-1.01.01.0-1.01.01.00.91.00.00.0
Time in closed arm after self-admin0.60.60.9-0.70.9-0.9-0.90.9-0.9-0.9-0.9-0.90.00.0
Time in open arm before self-admin0.60.71.00.01.0-1.0-1.01.0-1.0-1.0-0.8-0.90.00.0
Time in open arm after self-admin0.10.10.5-0.70.4-0.4-0.40.4-0.4-0.3-0.3-0.40.00.0
Bone: periosteal estimation0.30.62.51.6-0.70.70.7-0.70.70.70.60.60.00.0
Bone: periosteal perimeter0.20.41.41.2-0.60.60.6-0.70.70.60.70.50.00.0
Bone: post-yield work0.71.02.6-1.61.0-1.0-1.01.0-1.0-1.0-1.1-1.00.00.0
Progressive ratio test 1 active lever presses1.92.43.20.9-1.81.81.8-1.81.81.81.81.80.00.0
Progressive ratio test 1 breakpoint1.72.12.80.7-1.71.71.7-1.71.71.71.71.70.00.0
Progressive ratio test 1 inactive lever presses1.01.41.80.7-1.41.41.4-1.41.41.41.31.30.00.0
Progressive ratio test 2 active lever presses1.61.92.90.9-1.61.61.6-1.61.61.51.71.50.00.0
Progressive ratio test 2 breakpoint1.92.13.21.0-1.71.71.7-1.71.71.61.81.60.00.0
Progressive ratio test 2 inactive lever presses0.10.10.2-0.0-0.40.40.4-0.40.40.30.50.30.00.0
Incentive Sensitization - Responses0.91.21.81.3-1.21.21.2-1.21.21.21.31.10.00.0
Incentive Sensitization - Breakpoint0.91.11.61.2-1.21.21.2-1.21.21.11.31.10.00.0
Sum of active levers in priming session hrs 5-60.20.20.6-0.80.5-0.5-0.50.5-0.5-0.5-0.5-0.50.00.0
Progressive ratio1.01.63.6-1.91.3-1.3-1.31.3-1.3-1.3-1.1-1.30.00.0
Food seeking constrained by brief footshock4.65.610.4-3.22.6-2.6-2.62.5-2.5-2.5-2.6-2.50.00.0
Seeking ratio, punishment vs. effort0.40.61.2-0.90.9-0.9-0.90.9-0.8-0.8-1.1-0.70.00.0
Retroperitoneal fat weight0.00.10.40.7-0.30.30.3-0.30.30.40.40.30.00.0
Reaction time number correct2.95.57.70.5-2.82.82.8-2.82.82.72.72.80.00.0
Reaction time mean minus median0.10.21.11.00.3-0.3-0.30.3-0.3-0.3-0.5-0.20.00.0
Reaction time mean minus median AUC0.20.65.22.3-0.40.40.4-0.50.50.50.20.60.00.0
Reaction time num false alarms3.85.411.43.4-2.52.52.5-2.52.52.42.42.50.00.0
Reaction time num false alarms AUC2.94.69.83.1-2.32.32.3-2.32.32.22.32.20.00.0
Reaction time trials correct on left2.95.57.70.5-2.82.82.8-2.82.82.72.72.80.00.0
Reaction time trials on left2.95.57.70.5-2.82.82.8-2.82.82.72.72.80.00.0
Reaction time mean0.81.32.30.81.3-1.3-1.31.3-1.3-1.2-1.5-1.00.00.0
Reaction time mean AUC0.61.01.80.91.1-1.1-1.21.1-1.1-1.0-1.3-0.90.00.0
Median of all reaction times1.11.52.60.51.5-1.5-1.51.4-1.4-1.3-1.6-1.10.00.0
Reaction time omissions0.20.33.31.8-0.00.00.0-0.10.10.1-0.10.30.00.0
Reaction time false alarm rate0.30.54.02.0-0.40.40.4-0.40.40.40.50.30.00.0
Reaction time premature initiation rate0.30.40.6-0.00.8-0.8-0.80.7-0.7-0.8-0.8-0.60.00.0
Reaction time premature initiations0.20.40.70.4-0.70.70.7-0.70.70.60.60.80.00.0
Std. dev. reaction times0.20.31.21.10.5-0.5-0.50.5-0.5-0.5-0.7-0.40.00.0
Reaction time trials completed2.95.57.70.5-2.82.82.8-2.82.82.72.72.80.00.0
Reaction time trials AUC3.56.79.40.7-3.13.13.1-3.03.03.02.93.10.00.0
Run reversals in cocaine runway, females0.30.30.7-0.90.5-0.5-0.50.5-0.5-0.5-0.6-0.50.00.0
Run reversals in cocaine runway, males0.40.40.70.8-0.70.70.7-0.70.70.70.70.70.00.0
Latency to leave start box in cocaine runway0.10.10.30.4-0.30.30.3-0.30.30.40.20.60.00.0
Latency to leave start box in cocaine runway, F0.70.71.11.0-0.90.90.9-0.91.01.00.91.00.00.0
Latency to leave start box in cocaine runway, M0.10.10.2-0.00.3-0.3-0.30.3-0.3-0.2-0.4-0.10.00.0
Std. dev. time between licks in bursts0.00.00.1-0.3-0.10.10.1-0.10.10.20.10.30.00.0
Total sessions with >9 infusions2.83.44.71.1-2.22.22.2-2.12.12.22.22.10.00.0
Short access day 1 total inactive lever presses0.30.50.60.7-0.80.80.8-0.80.80.70.70.70.00.0
Short access day 10 total inactive lever presses0.41.11.6-0.31.2-1.2-1.21.2-1.2-1.3-1.2-1.20.00.0
Short access day 1 total infusions1.41.92.80.8-1.61.61.6-1.61.61.61.71.60.00.0
Short access day 10 total infusions2.83.64.71.5-2.22.22.2-2.12.12.22.12.10.00.0
Short access total infusions1.62.13.00.7-1.71.71.7-1.71.71.61.71.60.00.0
Short access day 1 locomotion2.43.04.10.8-2.02.02.0-2.02.02.02.02.00.00.0
Short access day 10 total locomotion0.10.11.41.2-0.10.10.1-0.10.10.1-0.00.10.00.0
Short access total locomotion0.60.71.00.8-1.01.00.9-1.01.01.00.91.00.00.0
One hour access (0.3 mA shock)0.00.00.2-0.4-0.20.20.2-0.20.20.20.10.20.00.0
Compulsive drug intake0.20.30.91.0-0.50.50.5-0.60.60.60.30.60.00.0
One hour access (shock baseline)0.60.91.30.3-1.11.11.1-1.11.11.11.11.10.00.0
Social response proportion1.21.44.62.1-1.11.11.1-1.21.21.20.91.30.00.0
Social responses0.91.24.02.0-1.11.11.1-1.11.11.11.01.10.00.0
Social time2.53.44.8-1.52.1-2.1-2.12.1-2.1-2.1-2.2-2.10.00.0
Soleus weight0.10.30.40.7-0.60.60.6-0.60.60.60.50.60.00.0
Bone: stiffness0.50.81.2-0.0-1.11.11.1-1.11.11.11.00.90.00.0
Tibialis anterior weight2.99.715.43.9-3.43.43.4-3.43.43.43.23.50.00.0
Time to tail flick, vehicle, before self-admin2.32.43.21.5-1.81.81.8-1.71.71.81.81.60.00.0
Time to tail flick, vehicle, after self-admin0.00.00.1-0.3-0.10.10.1-0.10.10.10.20.10.00.0
Time to tail flick, test, before self-admin0.40.40.8-0.90.7-0.7-0.70.7-0.7-0.7-0.6-0.60.00.0
Time to tail flick, test, after self-admin0.20.20.7-0.80.4-0.4-0.40.5-0.5-0.5-0.3-0.50.00.0
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.50.3-0.3-0.30.3-0.3-0.4-0.3-0.20.00.0
Delta time to tail flick, test, before/after SA0.60.60.80.7-0.90.90.9-0.90.90.90.90.70.00.0
Tibia length0.20.61.51.2-0.70.70.7-0.80.80.80.80.90.00.0
Ambulatory time before self-admin0.00.00.1-0.30.0-0.0-0.00.0-0.0-0.1-0.1-0.10.00.0
Ambulatory time after self-admin0.30.40.6-0.70.7-0.7-0.70.7-0.7-0.7-0.7-0.80.00.0
Bone: tissue strength0.60.60.9-0.50.9-0.9-0.90.9-0.9-0.9-1.0-0.90.00.0
Total heroin consumption0.00.00.3-0.50.1-0.1-0.10.1-0.1-0.1-0.1-0.10.00.0
Bone: trabecular number0.00.00.2-0.40.2-0.2-0.20.2-0.2-0.1-0.3-0.00.00.0
Bone: trabecular spacing0.10.21.71.3-0.20.20.2-0.20.20.00.20.00.00.0
Bone: trabecular thickness1.11.42.11.1-1.31.31.3-1.31.31.41.31.40.00.0
Bone: trabecular tissue density0.30.40.70.8-0.70.70.7-0.70.70.70.80.80.00.0
Water consumed over 24 hours0.10.10.20.20.4-0.4-0.40.3-0.3-0.3-0.5-0.10.00.0
Number of responses in last shaping day2.42.63.41.6-1.81.81.8-1.81.81.81.81.80.00.0