Hub : Genes

Rsph6a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg mRNA stability Rsph6a 0.12 0.1 5.0e-03 0.07 0.06 0.06 0.05 7.3e-03 1.1e-02 1.2e-02 2.1e-02
2 PL gene expression Rsph6a 0.02 0.02 5.5e-03 0.01 0.01 0 0.01 2.9e-02 1.9e-02 7.7e-02 5.2e-02
3 Brain gene expression Rsph6a 0.1 0.07 8.5e-10 0.09 0.1 0.08 0.09 2.2e-08 2.5e-09 2.9e-08 2.1e-08
4 Brain mRNA stability Rsph6a 0.1 0.07 9.3e-11 0.1 0.11 0.1 0.11 7.5e-10 2.8e-10 1.3e-09 4.3e-10
5 OFC mRNA stability Rsph6a 0.18 0.16 2.0e-03 0.12 0.12 0.09 0.09 1.0e-03 8.8e-04 3.2e-03 3.4e-03
6 OFC gene expression Rsph6a 0.16 0.15 4.4e-03 0.07 0.09 0.08 0.08 9.0e-03 4.9e-03 6.4e-03 5.9e-03
7 BLA mRNA stability Rsph6a 0.1 0.08 5.1e-05 0.04 0.06 0.06 0.06 2.0e-03 3.8e-04 7.1e-04 6.4e-04
8 NAcc gene expression Rsph6a 0.07 0.06 3.9e-11 0.06 0.07 0.06 0.06 5.6e-10 1.6e-10 4.2e-10 4.6e-10
9 IC mRNA stability Rsph6a 0.09 0.07 4.4e-03 0.04 0.04 0.03 0.04 7.3e-03 7.6e-03 3.1e-02 8.6e-03
10 IL mRNA stability Rsph6a 0.28 0.19 2.6e-05 0.17 0.2 0.19 0.19 8.6e-05 1.3e-05 2.6e-05 2.1e-05
11 PL mRNA stability Rsph6a 0.17 0.11 0.0e+00 0.18 0.18 0.18 0.18 2.2e-19 9.6e-20 3.8e-19 5.2e-19
12 IL intron excision ratio chr1_87842158_87842891 0.13 0.12 8.5e-03 0.09 0.09 0.08 0.09 2.9e-03 3.4e-03 5.8e-03 3.6e-03
13 pVTA mRNA stability Rsph6a 0.04 0.04 5.2e-03 0.02 0.01 0.02 0.01 1.3e-02 3.4e-02 1.2e-02 2.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.00.00.10.10.00.0-0.0-0.00.00.0-0.00.10.00.0-0.2-0.1
Area under the delay curve1.11.72.1-1.1-1.3-1.31.31.3-1.31.3-1.3-1.11.31.31.5-1.4
BMI with tail0.72.32.61.61.61.5-1.5-1.51.5-1.51.51.6-1.5-1.4-1.31.4
BMI without tail0.52.73.61.91.71.7-1.7-1.71.7-1.71.71.9-1.6-1.5-1.31.4
Body weight1.46.07.72.82.52.5-2.5-2.52.5-2.52.52.7-2.4-2.3-2.22.2
Weight adjusted by age0.00.00.30.50.10.1-0.1-0.10.1-0.10.10.1-0.1-0.10.00.1
Bone surface0.20.40.70.60.70.7-0.7-0.70.7-0.70.60.7-0.6-0.6-0.90.6
Bone volume0.20.30.70.60.60.6-0.6-0.60.6-0.50.50.6-0.5-0.5-0.80.4
Breakpoint value in progressive ratio session1.52.72.9-1.4-1.7-1.71.71.7-1.71.7-1.7-1.31.71.71.7-1.7
Number of licking bursts1.34.04.42.12.02.0-2.0-2.02.0-2.12.12.0-2.0-2.0-1.42.1
Context. condit. distance diff. score0.10.10.10.20.30.3-0.3-0.30.3-0.30.30.3-0.3-0.3-0.40.3
Locomotion velocity, session 10.10.10.1-0.2-0.3-0.30.30.3-0.30.3-0.2-0.20.30.20.3-0.3
Locomotion distance, session 10.00.00.1-0.0-0.00.1-0.0-0.00.0-0.0-0.0-0.1-0.1-0.1-0.40.1
Locomotion velocity, session 21.41.71.81.31.31.3-1.3-1.31.3-1.31.31.3-1.3-1.3-1.01.3
Locomotion distance, session 20.20.30.70.50.50.6-0.6-0.60.6-0.50.50.4-0.6-0.6-0.80.5
Locomotion velocity, session 30.20.30.30.50.50.5-0.5-0.50.5-0.50.50.5-0.5-0.5-0.50.5
Locomotion distance, session 30.70.81.0-1.0-0.9-0.90.90.9-0.90.9-0.9-1.00.90.90.8-0.9
Stereotopy head waving bouts, day 31.01.21.41.11.11.1-1.1-1.11.1-1.11.21.1-1.1-1.1-0.71.1
Stereotopy head waving duration, day 31.01.21.41.01.11.1-1.1-1.11.1-1.11.11.0-1.1-1.1-1.01.2
Locomotion velocity, session 70.20.20.3-0.5-0.5-0.50.50.5-0.50.5-0.5-0.40.50.50.1-0.4
Locomotion distance, session 70.00.00.10.10.10.1-0.1-0.10.1-0.10.10.1-0.1-0.1-0.30.2
Stereotopy head waving bouts, day 71.01.11.21.11.11.0-1.1-1.11.1-1.11.11.1-1.1-1.1-1.01.0
Stereotopy head waving duration, day 70.81.01.11.01.01.0-1.0-1.01.0-1.01.01.0-1.0-1.0-0.91.0
Locomotion velocity, session 80.00.00.0-0.1-0.1-0.10.10.1-0.10.1-0.0-0.20.10.00.1-0.0
Locomotion distance, session 80.00.00.1-0.00.00.0-0.0-0.00.0-0.0-0.0-0.0-0.0-0.0-0.4-0.0
Degree of sensitization distance0.50.60.70.70.70.8-0.8-0.80.8-0.80.80.8-0.8-0.8-0.70.8
Degree of sensitization stereotypy1.11.21.41.21.11.1-1.1-1.11.1-1.11.11.2-1.1-1.1-1.01.0
Conditioned locomotion0.00.10.1-0.1-0.2-0.20.20.2-0.20.2-0.2-0.20.20.20.2-0.2
Cocaine response after cond. corrected0.40.60.70.70.80.8-0.8-0.80.8-0.80.80.8-0.8-0.8-0.80.8
Cocaine response after cond. not corrected1.11.61.71.21.21.2-1.2-1.21.2-1.21.21.3-1.3-1.3-1.31.3
Cocaine response before conditioning1.62.02.21.41.41.4-1.4-1.41.4-1.41.41.5-1.4-1.4-1.31.4
Saline control response2.02.83.01.71.71.7-1.7-1.71.7-1.71.71.5-1.7-1.7-1.71.7
Bone: connectivity density0.00.00.1-0.1-0.2-0.10.20.2-0.20.2-0.2-0.00.20.2-0.0-0.3
Bone: cortical apparent density0.00.10.2-0.1-0.3-0.30.30.3-0.30.3-0.3-0.20.30.30.1-0.4
Bone: cortical area1.52.42.61.31.61.6-1.6-1.61.6-1.61.61.5-1.6-1.6-1.61.6
Bone: cortical porosity0.20.20.5-0.6-0.4-0.40.40.4-0.40.3-0.3-0.40.40.40.7-0.3
Bone: cortical porosity0.00.00.1-0.20.10.0-0.0-0.00.0-0.10.1-0.0-0.0-0.00.30.0
Bone: cortical thickness0.60.91.10.81.01.0-1.0-1.01.0-1.01.01.0-1.0-1.0-1.01.0
Bone: cortical thickness1.41.71.91.21.31.3-1.3-1.31.3-1.31.31.2-1.3-1.3-1.41.3
Bone: cortical tissue density0.10.10.3-0.3-0.4-0.40.40.4-0.40.4-0.4-0.30.40.40.2-0.5
Condit. Reinf. active minus inactive responses0.50.50.70.70.80.7-0.7-0.70.7-0.70.70.9-0.7-0.7-0.70.6
Condit. Reinf. active-inactive response ratio0.30.40.50.70.60.6-0.6-0.60.6-0.60.60.7-0.6-0.5-0.70.4
Condit. Reinf. active responses0.20.30.50.60.60.6-0.6-0.60.6-0.50.50.7-0.5-0.5-0.60.4
Condit. Reinf. inactive responses0.10.10.1-0.4-0.3-0.30.30.3-0.30.3-0.3-0.30.30.3-0.1-0.2
Incentive salience index mean0.30.40.60.70.70.6-0.6-0.60.6-0.60.60.8-0.6-0.5-0.50.4
Condit. Reinf. lever presses0.00.10.20.40.30.2-0.3-0.20.2-0.20.30.4-0.2-0.2-0.10.1
Condit. Reinf. active minus inactive responses0.00.10.10.30.20.3-0.2-0.30.3-0.20.20.2-0.3-0.3-0.30.3
Condit. Reinf. active-inactive response ratio0.20.30.70.50.50.6-0.6-0.60.6-0.50.50.4-0.6-0.6-0.90.6
Condit. Reinf. active responses0.10.10.1-0.3-0.3-0.30.30.3-0.30.3-0.3-0.30.30.30.4-0.3
Condit. Reinf. inactive responses0.50.81.1-0.9-0.9-0.90.90.9-0.90.9-0.9-0.80.90.91.1-0.9
Condit. Reinf. lever presses0.10.20.20.30.40.4-0.4-0.40.4-0.40.40.3-0.4-0.4-0.40.5
Condit. Reinf. lever reinforcers received0.10.10.2-0.4-0.4-0.30.40.4-0.40.4-0.4-0.40.40.30.4-0.3
Conditioned reinforcement - actives0.62.42.61.61.61.6-1.6-1.61.6-1.61.61.3-1.5-1.5-1.51.4
Conditioned reinforcement - inactives0.30.91.61.21.01.0-1.0-1.01.0-1.01.00.9-0.9-0.9-0.70.8
Conditioned locomotion1.92.83.21.81.61.7-1.6-1.71.7-1.61.61.6-1.7-1.7-1.71.7
Patch foraging indifference point 0 sec0.20.60.80.40.70.8-0.8-0.80.8-0.80.80.7-0.8-0.9-0.80.9
Patch foraging indifference point AUC2.25.16.62.62.32.2-2.2-2.22.2-2.32.32.5-2.2-2.2-1.92.2
Delay disc. indifference point, 0s delay1.01.21.8-0.7-1.0-1.11.11.1-1.11.1-1.0-1.01.11.11.4-1.2
Delay disc. indifference point, 16s delay0.71.01.3-1.0-1.0-1.01.01.0-1.01.0-1.0-1.01.01.10.9-1.1
Delay disc. indifference point, 2s delay3.03.45.8-1.4-1.8-1.81.81.8-1.81.8-1.8-1.71.81.92.4-1.9
Delay disc. indifference point, 24s delay0.00.00.2-0.20.10.1-0.1-0.10.1-0.10.10.0-0.1-0.2-0.50.2
Delay disc. indifference point, 4s delay0.00.00.10.40.00.0-0.0-0.00.0-0.00.00.2-0.00.00.20.0
Delay disc. indifference point, 8s delay1.11.82.1-1.1-1.3-1.41.41.4-1.41.4-1.3-1.11.41.41.5-1.4
Indifference point function ln k0.72.14.1-2.0-1.4-1.41.41.4-1.41.4-1.4-1.81.31.30.9-1.3
Indifference point function log k0.72.14.1-2.0-1.4-1.41.41.4-1.41.4-1.4-1.81.31.30.9-1.3
Patch foraging total patch changes 0 sec0.30.91.30.60.91.0-1.0-1.01.0-0.90.90.8-1.0-1.0-1.11.1
Patch foraging total patch changes 12 sec1.72.22.91.71.51.5-1.5-1.51.5-1.51.51.7-1.5-1.4-1.01.4
Patch foraging total patch changes 18 sec1.33.14.01.91.71.7-1.7-1.71.7-1.71.72.0-1.7-1.7-1.71.7
Patch foraging total patch changes 24 sec0.20.81.61.30.90.8-0.8-0.80.8-0.80.81.1-0.8-0.8-0.70.7
Patch foraging total patch changes 6 sec2.23.73.81.71.91.9-1.9-1.91.9-1.91.91.9-1.9-2.0-1.91.9
Patch foraging time to switch 0 sec1.24.86.3-1.9-2.2-2.22.22.2-2.22.2-2.1-2.02.22.32.5-2.3
Patch foraging water rate 0 sec1.55.76.72.12.42.4-2.4-2.42.4-2.42.42.2-2.4-2.5-2.62.4
Patch foraging water rate 12 sec0.10.20.60.20.40.5-0.5-0.50.5-0.40.40.2-0.5-0.5-0.80.4
Patch foraging water rate 18 sec0.10.20.50.20.40.4-0.4-0.40.4-0.40.3-0.0-0.4-0.4-0.70.3
Patch foraging water rate 24 sec0.40.60.90.70.70.8-0.8-0.80.8-0.80.70.6-0.8-0.8-1.00.9
Patch foraging water rate 6 sec0.60.91.50.80.91.0-1.0-1.01.0-0.90.90.8-0.9-1.0-1.20.9
Seeking ratio, delayed vs. immediate footshock1.62.32.5-1.3-1.6-1.61.61.6-1.61.6-1.6-1.41.51.51.4-1.6
Distance traveled before self-admin0.00.10.1-0.00.20.3-0.3-0.30.3-0.20.2-0.0-0.3-0.3-0.30.3
Distance traveled after self-admin0.20.30.6-0.8-0.5-0.50.50.5-0.50.5-0.5-0.80.50.50.4-0.4
Extensor digitorum longus weight1.97.78.42.92.82.8-2.8-2.82.8-2.82.82.9-2.7-2.7-2.82.6
Bone: elastic displacement0.70.91.5-0.7-0.9-1.01.01.0-1.01.0-0.9-0.71.01.01.1-1.2
Bone: elastic work0.00.10.10.40.30.2-0.2-0.20.2-0.20.30.3-0.2-0.2-0.20.1
Bone: endosteal estimation0.00.00.1-0.1-0.1-0.20.20.2-0.20.2-0.2-0.20.20.20.1-0.3
Bone: endosteal perimeter0.00.00.1-0.20.00.0-0.0-0.00.0-0.00.0-0.1-0.00.00.1-0.0
Epididymis fat weight0.10.61.1-0.6-0.7-0.80.80.8-0.80.8-0.7-0.60.80.81.0-0.9
Delta time in closed arm before/after self-admin0.30.20.7-0.7-0.5-0.50.50.5-0.50.5-0.5-0.90.40.40.2-0.3
Delta time in open arm before/after self-admin0.00.00.30.30.10.0-0.0-0.00.0-0.00.00.50.00.10.2-0.1
Diff in mean of infusions in LGA sessions0.91.61.9-0.9-1.3-1.41.31.3-1.31.3-1.3-1.01.31.31.3-1.3
Delay discount exponential model param0.91.21.50.91.11.1-1.1-1.11.1-1.11.11.0-1.1-1.1-1.21.1
Extinction: sum of active levers before priming0.00.00.1-0.1-0.2-0.20.20.2-0.20.2-0.20.00.20.20.3-0.2
Active lever presses in extinction session 60.10.10.20.50.40.3-0.4-0.40.4-0.40.40.4-0.3-0.3-0.20.2
Bone: final force0.40.70.80.90.80.9-0.8-0.80.8-0.80.80.9-0.8-0.8-0.80.8
Bone: final moment0.61.01.11.01.01.0-1.0-1.01.0-1.01.01.0-1.0-1.0-0.91.0
Food consumed during 24 hour testing period3.57.17.5-2.5-2.7-2.72.72.7-2.72.7-2.7-2.72.72.72.5-2.7
Glucose0.30.50.8-0.6-0.7-0.70.70.7-0.70.7-0.7-0.70.60.60.9-0.5
Heart weight2.03.23.71.61.81.8-1.8-1.81.8-1.81.81.6-1.8-1.8-1.81.9
Delay discount hyperbolic model param0.81.01.50.81.01.0-1.0-1.01.0-1.01.00.9-1.0-1.1-1.21.0
Intermittent access intake day 1-15 change0.00.10.20.30.40.4-0.4-0.40.4-0.40.40.3-0.4-0.4-0.40.4
Intermittent access intake escalation0.00.20.30.40.50.5-0.5-0.50.5-0.50.50.4-0.5-0.5-0.50.5
Intermittent access intake escalation 20.00.00.1-0.3-0.1-0.00.00.0-0.00.0-0.0-0.0-0.0-0.0-0.10.1
Intermitt. access day 1 inactive lever presses0.00.00.10.30.20.2-0.2-0.20.2-0.20.20.3-0.1-0.1-0.00.1
Intermitt. access day 15 inactive lever presses0.00.10.70.90.10.1-0.1-0.10.1-0.10.10.5-0.1-0.1-0.00.0
Intermitt. access escalation Index0.10.30.3-0.4-0.5-0.60.60.6-0.60.6-0.5-0.40.50.60.5-0.6
Intermittent access day 1 total infusions0.92.83.81.91.71.7-1.7-1.71.7-1.71.71.5-1.7-1.6-1.51.5
Intermittent access day 15 total infusions0.61.42.31.51.21.2-1.2-1.21.2-1.21.21.2-1.1-1.1-1.01.1
Intermittent access terminal intake (last 3 days)0.91.62.21.51.31.3-1.3-1.31.3-1.31.31.3-1.3-1.2-1.21.2
Intermittent access total infusions2.83.34.72.21.81.8-1.8-1.81.8-1.81.81.8-1.8-1.8-1.71.7
Intermittent access day 1 locomotion0.30.51.01.00.70.7-0.7-0.70.7-0.70.70.7-0.7-0.6-0.60.6
Intermittent access day 15 total locomotion0.10.30.50.70.50.5-0.5-0.50.5-0.50.50.3-0.5-0.5-0.50.5
Intermittent access total locomotion1.82.12.81.71.51.5-1.5-1.51.5-1.51.41.3-1.4-1.4-1.41.4
Intermittent access standard deviation0.00.20.3-0.5-0.5-0.50.50.5-0.50.5-0.5-0.30.50.50.5-0.4
Left kidney weight3.326.628.35.25.25.2-5.2-5.25.2-5.15.15.2-5.1-5.1-5.35.0
Right kidney weight3.424.025.54.94.94.9-4.9-4.94.9-4.94.85.1-4.9-4.9-4.94.8
Cocaine induced anxiety0.10.10.30.2-0.3-0.40.40.4-0.40.4-0.3-0.10.40.40.6-0.5
Post-drug Anxiety0.00.00.10.1-0.1-0.20.10.1-0.10.1-0.1-0.10.10.20.3-0.2
Baseline Anxiety0.00.10.4-0.7-0.3-0.20.20.2-0.20.2-0.2-0.40.10.1-0.00.1
Tail length0.31.92.61.61.41.4-1.4-1.41.4-1.41.41.5-1.3-1.3-1.11.1
Length with tail0.41.92.61.61.41.4-1.4-1.41.4-1.41.31.5-1.3-1.3-1.31.2
Length without tail0.21.21.71.31.11.1-1.1-1.11.1-1.01.01.3-1.0-1.0-1.21.0
Times rat made contact with spout0.00.00.1-0.4-0.2-0.20.20.2-0.20.2-0.2-0.20.20.2-0.1-0.2
Lifetime Intake2.73.45.02.21.91.8-1.8-1.81.8-1.81.81.9-1.8-1.8-1.71.7
Liver weight, left2.23.84.11.92.02.0-2.0-2.02.0-2.02.01.9-2.0-2.0-1.71.9
Liver weight, right1.62.73.31.71.71.7-1.7-1.71.7-1.61.61.8-1.6-1.6-1.61.4
Locomotor activity2.13.33.91.81.81.8-1.8-1.81.8-1.81.81.6-1.9-1.9-1.82.0
Locomotor testing distance0.92.12.41.61.51.5-1.5-1.51.5-1.51.51.2-1.5-1.5-1.41.5
Locomotor testing rearing2.59.110.33.23.03.0-3.0-3.03.0-3.03.03.0-3.0-3.0-2.83.0
Locomotion in novel chamber0.30.41.2-1.1-0.6-0.60.60.6-0.60.6-0.6-0.90.60.50.5-0.3
Locomotion in novel chamber post-restriction0.51.52.0-1.4-1.2-1.21.21.2-1.21.2-1.2-1.31.21.21.2-1.3
Fecal boli incidents, locomotor time 10.00.10.10.20.30.3-0.3-0.30.3-0.30.30.2-0.2-0.2-0.10.2
Change in fecal boli incidents, locomotor task0.60.70.8-0.7-0.8-0.80.80.8-0.80.8-0.8-0.70.80.80.9-0.9
Time >=10cm from walls, locomotor time 10.00.00.0-0.1-0.1-0.00.00.0-0.00.1-0.1-0.10.10.1-0.1-0.1
Bouts of movement, locomotor time 12.12.72.8-1.6-1.7-1.71.71.7-1.71.7-1.7-1.51.71.71.6-1.7
Total resting periods, locomotor time 12.93.43.6-1.7-1.9-1.91.91.9-1.91.9-1.9-1.61.91.91.8-1.9
Rest time, locomotor task time 10.10.20.2-0.5-0.5-0.50.50.5-0.50.5-0.5-0.30.50.50.4-0.5
Distance moved, locomotor task time 10.20.60.60.70.80.8-0.7-0.80.8-0.80.80.8-0.8-0.7-0.70.8
Vertical activity count, locomotor time 10.00.00.00.20.10.1-0.1-0.10.1-0.10.10.1-0.0-0.00.1-0.0
Time >=10cm from walls, locomotor time 20.00.10.2-0.2-0.2-0.20.20.2-0.20.2-0.2-0.40.20.20.4-0.2
Bouts of movement, locomotor time 22.37.78.1-2.8-2.8-2.82.82.8-2.82.8-2.8-2.62.82.82.5-2.7
Total resting periods, locomotor time 21.76.97.4-2.7-2.7-2.72.72.7-2.72.7-2.7-2.42.62.62.4-2.5
Rest time, locomotor task time 20.00.10.1-0.3-0.3-0.30.30.3-0.30.3-0.3-0.00.30.20.1-0.3
Distance moved, locomotor task time 20.81.01.10.91.01.0-1.0-1.01.0-1.01.10.9-1.0-1.0-0.91.0
Vertical activity count, locomotor time 20.00.00.20.0-0.1-0.10.10.1-0.10.1-0.1-0.20.20.20.4-0.2
Light reinforcement 10.00.10.40.30.30.4-0.4-0.40.4-0.30.30.3-0.3-0.3-0.60.3
Light reinforcement 20.10.20.50.70.50.5-0.5-0.50.5-0.50.50.6-0.4-0.4-0.40.3
Bone: marrow area0.00.00.10.0-0.1-0.10.10.1-0.10.1-0.1-0.10.10.20.0-0.2
Bone: maximum diameter2.14.34.41.92.12.1-2.1-2.12.1-2.12.12.1-2.1-2.1-2.02.0
Bone: maximum force0.20.30.40.60.60.6-0.6-0.60.6-0.60.60.6-0.6-0.6-0.60.6
Bone: maximum moment0.30.50.50.70.70.7-0.7-0.70.7-0.70.70.7-0.7-0.7-0.60.7
Mean time between licks in bursts0.00.10.1-0.3-0.2-0.20.20.2-0.20.2-0.2-0.10.20.30.4-0.3
Mean num. licks in bursts1.74.55.3-2.3-2.2-2.12.12.2-2.12.2-2.2-2.22.12.11.3-2.2
Cd content in liver0.10.10.2-0.2-0.4-0.40.40.4-0.40.4-0.4-0.20.30.3-0.0-0.3
Co content in liver1.21.41.7-1.0-1.2-1.21.21.2-1.21.2-1.2-1.01.21.21.3-1.2
Cu content in liver0.40.50.70.80.70.7-0.7-0.70.7-0.70.70.8-0.7-0.7-0.50.6
Fe content in liver4.96.06.52.52.42.4-2.4-2.52.4-2.52.52.5-2.5-2.5-2.32.5
K content in liver0.20.20.30.40.50.5-0.5-0.50.5-0.50.50.4-0.5-0.5-0.20.4
Mg content in liver0.60.70.80.80.90.9-0.9-0.90.9-0.90.90.8-0.8-0.8-0.50.8
Mn content in liver1.01.21.31.11.11.1-1.1-1.11.1-1.11.11.1-1.1-1.1-1.01.0
Na content in liver0.10.20.30.20.40.4-0.4-0.40.4-0.40.40.2-0.4-0.5-0.30.5
Rb content in liver0.10.10.20.10.20.3-0.3-0.30.3-0.20.20.1-0.3-0.3-0.50.2
Se content in liver4.14.95.22.22.32.2-2.2-2.22.2-2.32.32.2-2.2-2.2-1.92.2
Sr content in liver0.00.00.10.20.20.2-0.2-0.20.2-0.20.20.2-0.2-0.2-0.00.2
Zn content in liver0.81.01.11.01.01.0-1.0-1.01.0-1.01.01.0-1.0-1.0-0.90.9
Bone: minimum diameter0.20.30.50.30.60.6-0.6-0.60.6-0.60.60.5-0.6-0.6-0.70.5
Time in familiar zone, hab. session 10.10.10.20.20.30.4-0.4-0.40.4-0.40.40.2-0.4-0.4-0.40.5
Time in novel zone, hab. session 10.60.71.01.00.90.8-0.8-0.80.8-0.80.81.0-0.8-0.8-0.60.8
Total zone transitions, hab. session 10.10.20.50.30.40.4-0.4-0.40.4-0.40.30.2-0.4-0.4-0.70.4
Total locomotion distance, hab. session 10.40.50.7-0.8-0.7-0.70.70.7-0.70.7-0.7-0.80.70.70.7-0.7
Locomotion velocity, hab. session 11.21.71.9-1.4-1.3-1.31.31.3-1.31.3-1.3-1.41.31.31.2-1.3
Time in familiar zone, hab. session 20.30.40.60.80.60.6-0.6-0.60.6-0.60.60.7-0.6-0.6-0.40.5
Time in novel zone, hab. session 20.10.10.3-0.6-0.4-0.30.30.3-0.30.3-0.3-0.50.30.30.2-0.2
Total zone transitions, hab. session 20.50.60.70.70.80.8-0.8-0.80.8-0.80.80.7-0.8-0.8-0.70.8
Total locomotion distance, hab. session 20.50.70.8-0.8-0.8-0.80.80.8-0.80.8-0.8-0.90.80.80.9-0.8
Locomotion velocity, hab. session 20.30.40.6-0.7-0.6-0.60.60.6-0.60.6-0.6-0.80.60.60.7-0.7
Novel to familiar place preference ratio0.40.51.60.50.60.7-0.7-0.70.7-0.70.60.5-0.7-0.7-1.30.7
Novelty place preference0.30.41.40.50.60.7-0.6-0.60.6-0.60.50.4-0.6-0.7-1.20.7
Time in novel zone, NPP test0.50.61.50.50.70.8-0.7-0.70.7-0.70.60.5-0.7-0.8-1.20.8
Total zone transitions, NPP test0.10.10.20.10.30.4-0.4-0.40.4-0.40.30.2-0.4-0.4-0.40.4
Total locomotion distance, NPP test0.10.10.20.10.20.3-0.3-0.30.3-0.30.30.1-0.3-0.3-0.40.4
Locomotion velocity, NPP test0.00.10.20.00.20.2-0.2-0.20.2-0.20.20.0-0.2-0.3-0.40.3
Intraocular pressure0.00.00.1-0.3-0.2-0.20.20.2-0.20.2-0.2-0.20.10.10.1-0.0
Delta distance traveled before/after self-admin1.51.62.0-1.1-1.2-1.31.31.3-1.31.3-1.3-1.21.31.31.4-1.4
Delta ambulatory time before/after self-admin0.20.40.5-0.7-0.6-0.60.60.6-0.60.6-0.6-0.70.60.60.7-0.7
Parametrial fat weight0.10.20.20.40.40.4-0.4-0.40.4-0.40.40.4-0.4-0.4-0.30.4
Pavlov. Cond. lever latency0.50.70.8-0.9-0.8-0.80.80.8-0.80.8-0.8-0.90.80.80.8-0.7
Pavlov. Cond. magazine entry latency0.10.10.20.50.40.3-0.4-0.30.3-0.30.40.4-0.3-0.3-0.30.2
Pavlov. Cond. change in total contacts0.50.60.7-0.6-0.8-0.80.80.8-0.80.8-0.8-0.70.80.80.7-0.9
Pavlov. Cond. index score0.30.40.50.70.60.6-0.6-0.60.6-0.60.60.6-0.6-0.6-0.50.5
Pavlov. Cond. latency score0.10.10.20.40.30.3-0.3-0.30.3-0.30.30.4-0.3-0.3-0.20.2
Pavlov. Cond. lever contacts0.40.40.60.80.70.6-0.7-0.70.7-0.70.70.7-0.6-0.6-0.60.5
Pavlov. Cond. magazine entry number0.00.00.1-0.3-0.2-0.20.20.2-0.20.2-0.2-0.20.20.10.0-0.0
Pavlov. Cond. intertrial magazine entries0.10.10.20.20.20.2-0.2-0.20.2-0.20.20.4-0.2-0.2-0.30.3
Pavlov. Cond. lever-magazine prob. diff.0.30.40.50.70.60.6-0.6-0.60.6-0.60.60.7-0.6-0.6-0.60.5
Pavlov. Cond. response bias0.91.11.41.21.11.1-1.1-1.11.1-1.11.11.1-1.1-1.0-1.10.9
Pavlov. Cond. lever latency0.00.00.0-0.1-0.1-0.10.10.1-0.10.1-0.1-0.10.10.1-0.1-0.2
Pavlov. Cond. magazine entry latency0.00.00.10.20.10.1-0.1-0.10.1-0.00.00.2-0.1-0.0-0.30.0
Pavlov. Cond. change in total contacts0.10.40.6-0.8-0.6-0.60.60.6-0.60.6-0.6-0.70.60.50.5-0.5
Pavlov. Cond. index score0.00.00.0-0.2-0.2-0.20.20.2-0.20.2-0.2-0.20.20.20.1-0.2
Pavlov. Cond. latency score0.10.10.1-0.3-0.3-0.30.30.3-0.30.3-0.3-0.30.30.30.2-0.3
Pavlov. Cond. lever contacts0.10.10.10.30.30.3-0.3-0.30.3-0.30.30.3-0.3-0.3-0.20.3
Pavlov. Cond. magazine entry number0.30.40.40.60.70.6-0.7-0.70.7-0.70.70.6-0.7-0.7-0.60.6
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.00.00.1-0.1-0.10.1-0.10.1-0.0-0.1-0.1-0.10.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.0-0.00.0-0.0-0.00.00.0-0.0-0.0-0.0-0.0-0.10.0
Pavlov. Cond. response bias0.00.00.0-0.1-0.0-0.00.00.0-0.00.1-0.1-0.10.10.10.1-0.0
Time in closed arm before self-admin0.61.11.91.40.91.0-1.0-1.01.0-1.00.91.2-1.0-1.0-1.11.0
Time in closed arm after self-admin0.91.11.5-0.9-1.1-1.01.01.0-1.01.1-1.1-1.21.01.00.8-0.9
Time in open arm before self-admin0.80.91.5-1.2-0.9-0.90.90.9-0.90.9-0.9-1.20.90.91.0-0.9
Time in open arm after self-admin0.10.10.2-0.1-0.1-0.20.20.2-0.20.2-0.10.20.20.30.4-0.4
Bone: periosteal estimation0.20.60.70.60.80.8-0.8-0.80.8-0.80.80.6-0.8-0.7-0.90.7
Bone: periosteal perimeter0.20.50.60.50.80.7-0.7-0.70.7-0.70.70.6-0.7-0.7-0.60.6
Bone: post-yield work0.61.01.1-1.0-1.0-1.01.01.0-1.01.0-1.0-1.01.01.00.9-1.0
Progressive ratio test 1 active lever presses2.13.74.42.12.02.0-1.9-1.91.9-1.91.91.8-1.9-1.9-1.81.8
Progressive ratio test 1 breakpoint1.93.34.12.01.91.9-1.9-1.91.9-1.91.91.7-1.8-1.8-1.71.7
Progressive ratio test 1 inactive lever presses0.82.23.11.81.51.5-1.5-1.51.5-1.51.51.3-1.4-1.4-1.31.4
Progressive ratio test 2 active lever presses2.23.24.32.11.81.8-1.8-1.81.8-1.81.81.8-1.7-1.7-1.51.6
Progressive ratio test 2 breakpoint2.73.54.82.21.91.9-1.9-1.91.9-1.91.91.9-1.8-1.8-1.61.7
Progressive ratio test 2 inactive lever presses0.10.51.31.10.70.7-0.7-0.70.7-0.70.70.6-0.6-0.5-0.30.5
Incentive Sensitization - Responses0.71.82.01.41.41.4-1.4-1.41.4-1.41.41.4-1.3-1.3-1.11.3
Incentive Sensitization - Breakpoint0.71.61.91.41.31.3-1.3-1.31.3-1.31.31.4-1.3-1.2-1.11.2
Sum of active levers in priming session hrs 5-60.30.30.3-0.5-0.5-0.60.60.5-0.50.5-0.5-0.30.50.50.5-0.5
Progressive ratio0.51.62.1-1.1-1.2-1.31.31.2-1.21.2-1.2-1.21.21.31.4-1.4
Food seeking constrained by brief footshock5.46.77.5-2.5-2.6-2.62.62.6-2.62.6-2.6-2.72.62.62.4-2.5
Seeking ratio, punishment vs. effort0.40.80.9-0.9-0.9-0.90.90.9-0.90.9-1.0-1.00.90.90.7-0.8
Retroperitoneal fat weight0.00.10.30.50.40.3-0.4-0.40.4-0.40.40.5-0.4-0.3-0.20.4
Reaction time number correct1.96.97.92.22.62.6-2.6-2.62.6-2.62.62.4-2.7-2.7-2.82.8
Reaction time mean minus median0.10.40.9-0.9-0.7-0.60.60.6-0.60.6-0.6-0.60.50.50.3-0.3
Reaction time mean minus median AUC0.00.00.2-0.20.10.1-0.1-0.10.1-0.10.10.2-0.2-0.3-0.50.4
Reaction time num false alarms4.06.78.02.82.62.6-2.6-2.62.6-2.62.62.6-2.6-2.5-2.52.4
Reaction time num false alarms AUC2.65.96.62.62.52.4-2.5-2.42.4-2.42.52.4-2.4-2.4-2.32.2
Reaction time trials correct on left1.96.97.92.22.62.6-2.6-2.62.6-2.62.62.4-2.7-2.7-2.82.8
Reaction time trials on left2.06.87.92.22.62.6-2.6-2.62.6-2.62.62.5-2.7-2.7-2.82.8
Reaction time mean1.02.22.5-1.6-1.5-1.51.51.5-1.51.5-1.5-1.31.51.51.2-1.4
Reaction time mean AUC0.71.62.0-1.4-1.4-1.31.31.3-1.31.3-1.3-1.21.31.30.9-1.2
Median of all reaction times1.52.32.5-1.5-1.6-1.61.61.6-1.61.6-1.6-1.41.61.61.3-1.5
Reaction time omissions0.00.00.10.00.00.1-0.0-0.00.0-0.00.00.3-0.0-0.0-0.2-0.0
Reaction time false alarm rate0.20.30.80.90.60.6-0.6-0.60.6-0.60.60.6-0.5-0.5-0.30.4
Reaction time premature initiation rate0.40.61.2-0.8-0.7-0.70.70.7-0.70.7-0.7-1.10.80.80.7-0.8
Reaction time premature initiations0.10.30.60.20.60.6-0.6-0.60.6-0.60.60.1-0.6-0.6-0.80.6
Std. dev. reaction times0.20.50.9-1.0-0.8-0.80.80.8-0.80.8-0.8-0.60.70.70.5-0.5
Reaction time trials completed2.06.87.92.22.62.6-2.6-2.62.6-2.62.62.5-2.7-2.7-2.82.8
Reaction time trials AUC2.48.49.62.52.92.9-2.9-2.92.9-2.92.92.7-3.0-3.0-3.13.0
Run reversals in cocaine runway, females0.30.30.5-0.5-0.5-0.50.50.5-0.50.5-0.5-0.70.50.50.5-0.5
Run reversals in cocaine runway, males0.40.50.60.70.70.7-0.7-0.70.7-0.70.70.8-0.7-0.7-0.70.7
Latency to leave start box in cocaine runway0.10.10.6-0.7-0.00.1-0.0-0.00.0-0.0-0.0-0.6-0.1-0.2-0.60.1
Latency to leave start box in cocaine runway, F0.40.51.1-0.30.60.7-0.7-0.70.7-0.70.6-0.1-0.7-0.8-1.00.8
Latency to leave start box in cocaine runway, M0.10.10.2-0.3-0.4-0.40.40.4-0.40.4-0.4-0.40.40.40.1-0.4
Std. dev. time between licks in bursts0.00.00.20.10.20.2-0.2-0.20.2-0.10.10.2-0.1-0.1-0.4-0.0
Total sessions with >9 infusions3.94.85.22.32.22.2-2.2-2.22.2-2.22.22.2-2.2-2.2-2.12.2
Short access day 1 total inactive lever presses0.61.22.11.51.21.1-1.1-1.11.1-1.11.11.3-1.0-0.9-0.70.8
Short access day 10 total inactive lever presses0.21.31.6-1.0-1.1-1.21.21.2-1.21.2-1.1-0.81.21.21.2-1.1
Short access day 1 total infusions1.42.83.11.71.71.7-1.7-1.71.7-1.71.71.7-1.7-1.7-1.61.6
Short access day 10 total infusions3.05.05.92.42.32.3-2.3-2.32.3-2.22.22.2-2.2-2.2-2.12.1
Short access total infusions2.33.34.22.01.91.8-1.8-1.81.8-1.81.81.8-1.8-1.7-1.61.7
Short access day 1 locomotion2.94.87.02.62.22.2-2.2-2.22.2-2.22.22.4-2.1-2.1-2.02.0
Short access day 10 total locomotion0.00.00.1-0.2-0.00.00.00.0-0.00.0-0.00.0-0.0-0.0-0.10.0
Short access total locomotion0.71.01.41.21.01.0-1.0-1.01.0-1.01.01.1-1.0-1.0-1.00.9
One hour access (0.3 mA shock)0.10.10.20.40.20.3-0.2-0.20.2-0.20.20.2-0.2-0.2-0.20.2
Compulsive drug intake0.10.10.40.10.30.4-0.3-0.30.3-0.30.30.3-0.4-0.4-0.60.5
One hour access (shock baseline)0.61.73.31.81.31.3-1.3-1.31.3-1.31.31.4-1.2-1.2-1.11.1
Social response proportion0.70.91.80.80.91.0-1.0-0.90.9-0.90.90.9-1.0-1.0-1.41.0
Social responses0.81.01.40.71.01.0-1.0-1.01.0-1.01.01.0-1.0-1.0-1.21.0
Social time3.04.76.5-2.5-2.1-2.12.12.1-2.12.1-2.1-2.32.12.12.0-2.1
Soleus weight0.10.40.50.70.60.6-0.6-0.60.6-0.60.60.6-0.6-0.6-0.70.5
Bone: stiffness0.71.31.51.11.11.2-1.1-1.11.1-1.11.11.1-1.1-1.1-1.11.2
Tibialis anterior weight3.411.712.73.53.43.4-3.4-3.43.4-3.43.43.4-3.4-3.4-3.63.3
Time to tail flick, vehicle, before self-admin2.43.03.11.51.71.7-1.8-1.71.7-1.71.71.7-1.8-1.8-1.81.8
Time to tail flick, vehicle, after self-admin0.00.00.2-0.4-0.1-0.00.00.0-0.00.0-0.1-0.3-0.0-0.1-0.10.2
Time to tail flick, test, before self-admin0.30.40.5-0.4-0.6-0.60.60.6-0.60.6-0.6-0.20.60.70.7-0.7
Time to tail flick, test, after self-admin0.10.10.3-0.4-0.3-0.30.30.3-0.30.3-0.3-0.50.40.40.4-0.4
Delta time to tail flick, vehicle, before/after SA0.20.20.5-0.7-0.5-0.40.40.4-0.40.4-0.4-0.60.40.40.3-0.3
Delta time to tail flick, test, before/after SA0.70.80.90.70.91.0-1.0-0.90.9-0.90.90.6-0.9-0.9-1.01.0
Tibia length0.20.71.11.00.90.9-0.8-0.80.8-0.80.80.9-0.8-0.8-0.70.7
Ambulatory time before self-admin0.00.00.2-0.4-0.1-0.10.10.1-0.10.1-0.1-0.10.10.10.1-0.0
Ambulatory time after self-admin0.40.71.5-1.2-0.8-0.80.80.8-0.80.8-0.8-1.00.80.70.7-0.7
Bone: tissue strength0.80.90.9-0.9-0.9-0.90.90.9-0.90.9-0.9-0.90.90.90.9-0.9
Total heroin consumption0.00.00.00.10.0-0.00.00.0-0.00.0-0.00.20.00.10.1-0.1
Bone: trabecular number0.00.00.1-0.1-0.2-0.20.20.2-0.20.2-0.2-0.10.20.30.0-0.3
Bone: trabecular spacing0.00.00.1-0.00.20.2-0.2-0.20.2-0.20.20.0-0.2-0.2-0.00.3
Bone: trabecular thickness1.31.92.21.41.41.4-1.4-1.41.4-1.31.31.4-1.3-1.3-1.51.3
Bone: trabecular tissue density0.20.40.50.50.70.7-0.7-0.70.7-0.70.70.5-0.7-0.7-0.70.7
Water consumed over 24 hours0.10.20.3-0.4-0.5-0.50.50.5-0.50.5-0.5-0.50.50.50.1-0.5
Number of responses in last shaping day2.63.44.72.01.81.8-1.8-1.81.8-1.81.82.2-1.8-1.8-1.81.8