Hub : Genes

Rsph1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Rsph1 0.06 0.03 6.0e-10 0.07 0.09 0.09 0.09 3.4e-08 7.3e-10 2.3e-10 5.2e-10
2 BLA gene expression Rsph1 0.47 0.13 0.0e+00 0.5 0.5 0.52 0.51 8.6e-30 2.0e-30 2.3e-31 3.8e-31
3 IL gene expression Rsph1 0.47 0.13 1.5e-10 0.33 0.24 0.25 0.26 1.0e-08 1.5e-06 8.8e-07 8.1e-07
4 OFC gene expression Rsph1 0.39 0.14 1.3e-08 0.29 0.29 0.34 0.32 1.2e-07 1.3e-07 8.4e-09 1.8e-08
5 LHb gene expression Rsph1 0.23 0.12 9.0e-05 0.17 0.09 0.09 0.13 6.5e-05 4.9e-03 4.5e-03 5.0e-04
6 RMTg gene expression Rsph1 0.19 0.08 2.3e-06 0.2 0.24 0.15 0.24 5.0e-06 6.4e-07 1.1e-04 4.4e-07
7 Brain gene expression Rsph1 0.26 0.08 0.0e+00 0.41 0.4 0.4 0.41 2.9e-41 4.1e-40 1.7e-39 1.8e-41
8 IC gene expression Rsph1 0.31 0.1 1.7e-16 0.28 0.34 0.32 0.34 4.1e-12 9.9e-15 2.9e-14 7.2e-15
9 PL gene expression Rsph1 0.46 0.1 0.0e+00 0.56 0.56 0.57 0.58 8.8e-74 6.5e-73 2.2e-76 1.1e-76
10 NAcc gene expression Rsph1 0.12 0.05 0.0e+00 0.17 0.19 0.18 0.19 1.2e-24 9.3e-28 5.2e-27 2.0e-27
11 BLA mRNA stability Rsph1 0.04 0.03 5.3e-03 0.04 0.03 0.02 0.02 4.5e-03 9.4e-03 3.9e-02 2.3e-02
12 pVTA gene expression Rsph1 0.32 0.11 0.0e+00 0.46 0.45 0.46 0.46 1.1e-40 7.6e-40 9.1e-41 7.2e-41
13 Brain mRNA stability Rsph1 0.06 0.03 1.3e-09 0.12 0.11 0.1 0.1 5.4e-11 1.5e-10 1.1e-09 1.4e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.20.6-0.8-0.7-0.4-0.8-0.1-0.2-0.4-0.2-0.5-0.3-0.2-0.4-0.5
Area under the delay curve0.40.50.9-0.1-0.7-0.8-1.0-0.6-0.7-0.8-0.6-0.8-0.6-0.3-0.6-0.7
BMI with tail1.03.44.72.02.01.31.62.21.91.71.91.62.02.01.61.7
BMI without tail1.02.93.71.81.81.41.91.61.71.81.71.61.71.61.61.9
Body weight2.912.715.84.03.83.43.33.83.73.43.53.53.43.63.53.4
Weight adjusted by age2.94.45.02.22.22.02.22.12.02.02.22.12.12.22.01.9
Bone surface0.10.20.5-0.1-0.10.4-0.00.70.70.40.40.50.50.60.50.3
Bone volume0.10.20.5-0.1-0.10.50.20.70.70.40.50.40.50.60.40.3
Breakpoint value in progressive ratio session0.81.01.8-0.8-0.8-1.0-1.1-1.3-1.1-1.0-0.9-1.0-1.0-0.9-1.0-1.0
Number of licking bursts0.20.30.9-0.4-0.9-0.6-0.7-0.0-0.2-0.5-0.2-0.5-0.4-0.6-0.5-0.5
Context. condit. distance diff. score1.51.83.0-1.5-1.2-1.7-1.3-1.5-1.3-1.3-1.2-1.3-1.3-1.2-1.3-1.1
Locomotion velocity, session 12.02.12.7-1.4-1.2-1.6-1.5-1.6-1.5-1.4-1.4-1.4-1.5-1.4-1.4-1.4
Locomotion distance, session 12.43.03.3-1.7-1.7-1.7-1.8-1.8-1.8-1.7-1.8-1.7-1.7-1.7-1.7-1.7
Locomotion velocity, session 21.01.21.7-0.8-1.1-1.2-1.0-0.9-1.0-1.3-1.1-1.0-1.2-1.1-1.0-1.3
Locomotion distance, session 20.91.21.6-1.1-0.9-1.3-1.1-0.9-1.2-1.1-1.0-1.1-1.2-1.1-1.2-1.1
Locomotion velocity, session 30.10.10.2-0.4-0.1-0.2-0.1-0.4-0.4-0.3-0.3-0.3-0.4-0.5-0.3-0.4
Locomotion distance, session 30.90.91.3-0.9-0.8-1.1-1.1-0.8-1.0-0.9-0.8-1.1-1.0-1.0-1.1-0.9
Stereotopy head waving bouts, day 30.20.20.40.60.60.60.50.30.20.30.30.40.20.20.40.3
Stereotopy head waving duration, day 30.00.00.20.20.20.40.3-0.2-0.1-0.0-0.00.1-0.1-0.10.1-0.1
Locomotion velocity, session 70.40.40.7-0.5-0.6-0.8-0.6-0.8-0.7-0.5-0.6-0.6-0.6-0.7-0.7-0.5
Locomotion distance, session 71.01.31.9-0.8-1.2-1.4-0.9-1.1-1.1-1.1-1.1-1.2-1.1-1.2-1.2-1.1
Stereotopy head waving bouts, day 70.20.20.40.60.40.60.50.60.40.30.50.40.20.30.40.3
Stereotopy head waving duration, day 70.10.10.50.60.40.70.40.40.20.20.30.30.10.20.20.2
Locomotion velocity, session 80.50.50.8-0.8-0.7-0.8-0.8-0.9-0.8-0.7-0.8-0.6-0.7-0.7-0.6-0.6
Locomotion distance, session 81.82.74.1-1.7-1.6-2.0-1.5-1.7-1.7-1.6-1.5-1.5-1.7-1.6-1.6-1.5
Degree of sensitization distance0.20.20.40.40.20.20.60.20.40.40.30.50.60.40.50.4
Degree of sensitization stereotypy0.10.10.2-0.3-0.4-0.2-0.3-0.1-0.4-0.4-0.2-0.4-0.5-0.4-0.4-0.4
Conditioned locomotion0.91.01.30.90.91.10.81.01.11.00.91.11.11.01.11.0
Cocaine response after cond. corrected0.60.81.10.91.00.51.00.81.00.71.01.01.00.80.90.7
Cocaine response after cond. not corrected0.70.81.20.90.90.60.90.71.00.81.11.01.10.91.00.8
Cocaine response before conditioning0.10.10.3-0.4-0.5-0.2-0.4-0.3-0.2-0.1-0.2-0.2-0.1-0.1-0.1-0.2
Saline control response0.81.11.70.60.80.61.21.21.11.11.01.01.21.30.91.1
Bone: connectivity density0.20.41.3-0.9-0.7-0.7-1.1-0.2-0.4-0.5-0.3-0.7-0.4-0.2-0.6-0.5
Bone: cortical apparent density0.50.71.60.80.71.30.60.80.90.70.51.10.70.61.10.6
Bone: cortical area0.50.71.20.60.90.70.91.10.90.90.80.70.80.90.70.9
Bone: cortical porosity0.20.20.5-0.7-0.6-0.4-0.1-0.6-0.5-0.4-0.7-0.6-0.4-0.3-0.5-0.3
Bone: cortical porosity0.00.00.2-0.4-0.1-0.20.40.0-0.10.2-0.2-0.20.10.3-0.00.2
Bone: cortical thickness0.00.00.1-0.20.1-0.10.10.40.20.20.10.00.40.30.10.3
Bone: cortical thickness0.20.30.70.10.6-0.10.10.80.30.60.80.10.70.60.20.6
Bone: cortical tissue density0.50.71.70.80.71.30.70.81.00.70.61.10.80.61.10.6
Condit. Reinf. active minus inactive responses0.10.20.4-0.3-0.30.2-0.2-0.7-0.5-0.1-0.6-0.4-0.5-0.2-0.3-0.3
Condit. Reinf. active-inactive response ratio0.10.10.40.30.20.60.30.10.20.50.20.20.20.50.30.3
Condit. Reinf. active responses0.30.30.7-0.6-0.4-0.3-0.6-0.6-0.6-0.5-0.9-0.5-0.7-0.4-0.5-0.6
Condit. Reinf. inactive responses1.01.21.8-1.4-0.9-1.2-1.2-0.9-1.0-1.1-1.2-1.0-1.1-1.0-0.9-1.2
Incentive salience index mean0.10.10.20.0-0.10.4-0.2-0.4-0.20.1-0.4-0.1-0.4-0.1-0.1-0.1
Condit. Reinf. lever presses0.00.00.10.1-0.10.2-0.40.00.10.10.00.1-0.20.10.1-0.0
Condit. Reinf. active minus inactive responses0.50.71.2-1.1-0.5-0.9-1.0-0.6-0.9-0.8-0.8-0.9-0.7-0.6-0.8-0.8
Condit. Reinf. active-inactive response ratio0.00.00.1-0.20.3-0.3-0.4-0.0-0.1-0.00.0-0.20.20.2-0.1-0.0
Condit. Reinf. active responses0.60.81.4-1.2-0.8-0.9-1.0-0.5-1.0-1.0-0.9-1.0-0.9-0.7-1.0-1.0
Condit. Reinf. inactive responses0.20.30.5-0.6-0.6-0.3-0.30.0-0.5-0.6-0.5-0.6-0.7-0.5-0.5-0.6
Condit. Reinf. lever presses2.02.83.8-2.0-1.7-1.6-1.9-1.5-1.7-1.7-1.4-1.7-1.6-1.5-1.6-1.6
Condit. Reinf. lever reinforcers received1.01.42.1-1.5-1.1-1.2-1.4-0.7-1.2-1.3-1.1-1.3-1.1-1.0-1.2-1.2
Conditioned reinforcement - actives0.50.91.3-0.9-0.9-0.7-1.0-1.1-1.0-0.9-1.0-0.9-1.1-0.8-0.9-0.9
Conditioned reinforcement - inactives1.52.23.0-1.5-1.6-1.0-1.6-1.7-1.5-1.3-1.7-1.4-1.3-1.6-1.4-1.3
Conditioned locomotion0.10.20.6-0.3-0.5-0.1-0.7-0.5-0.3-0.3-0.4-0.3-0.5-0.2-0.4-0.5
Patch foraging indifference point 0 sec0.30.60.90.70.80.90.90.80.70.80.60.70.70.70.60.8
Patch foraging indifference point AUC0.20.20.4-0.1-0.2-0.3-0.5-0.4-0.6-0.6-0.4-0.6-0.6-0.4-0.6-0.5
Delay disc. indifference point, 0s delay0.20.30.90.3-0.00.00.20.60.40.50.40.40.71.00.70.5
Delay disc. indifference point, 16s delay1.01.11.6-0.9-1.0-1.1-1.1-1.3-1.1-1.1-1.1-1.1-1.0-0.8-1.0-1.1
Delay disc. indifference point, 2s delay0.30.40.6-0.7-0.8-0.7-0.8-0.6-0.6-0.6-0.7-0.6-0.3-0.2-0.4-0.5
Delay disc. indifference point, 24s delay0.40.50.90.90.90.60.80.20.70.70.70.50.60.80.70.6
Delay disc. indifference point, 4s delay0.00.00.30.50.1-0.0-0.3-0.0-0.2-0.20.0-0.10.00.40.1-0.1
Delay disc. indifference point, 8s delay0.50.61.30.0-0.8-0.9-1.1-0.4-0.7-1.0-0.7-0.9-0.7-0.5-0.7-0.9
Indifference point function ln k0.00.10.40.1-0.10.60.2-0.10.20.30.00.20.10.10.20.2
Indifference point function log k0.00.10.40.1-0.10.60.2-0.10.20.30.00.20.10.10.20.2
Patch foraging total patch changes 0 sec0.40.71.00.80.80.90.91.00.80.90.70.70.80.80.70.8
Patch foraging total patch changes 12 sec0.40.50.80.80.80.90.60.60.70.70.70.60.60.80.60.8
Patch foraging total patch changes 18 sec0.40.61.00.80.80.40.80.90.70.80.60.70.81.00.80.9
Patch foraging total patch changes 24 sec0.00.00.2-0.2-0.1-0.4-0.1-0.1-0.2-0.2-0.2-0.3-0.2-0.1-0.2-0.2
Patch foraging total patch changes 6 sec0.20.40.70.40.50.50.70.80.60.60.50.50.70.70.60.5
Patch foraging time to switch 0 sec0.20.40.70.20.70.00.70.70.60.40.60.70.90.80.80.6
Patch foraging water rate 0 sec0.20.40.70.80.60.80.50.60.70.80.60.60.60.50.50.7
Patch foraging water rate 12 sec0.10.20.30.30.50.40.10.50.40.50.50.40.40.50.40.5
Patch foraging water rate 18 sec0.50.82.0-0.8-0.9-0.8-1.4-0.6-0.7-0.7-0.8-0.9-0.9-0.7-1.0-0.9
Patch foraging water rate 24 sec0.10.10.7-0.3-0.5-0.4-0.80.3-0.1-0.3-0.1-0.4-0.4-0.1-0.3-0.4
Patch foraging water rate 6 sec0.20.30.60.60.80.70.10.40.50.70.70.50.50.50.40.5
Seeking ratio, delayed vs. immediate footshock0.91.11.8-1.0-0.7-1.2-1.3-0.9-0.9-1.1-0.8-1.1-0.9-1.0-1.0-1.0
Distance traveled before self-admin1.01.31.81.11.31.30.90.81.11.11.11.11.21.11.11.2
Distance traveled after self-admin0.00.00.30.50.30.20.1-0.1-0.0-0.10.1-0.0-0.00.30.0-0.0
Extensor digitorum longus weight0.41.62.3-1.5-1.2-1.3-1.4-1.0-1.1-1.4-1.5-1.2-1.2-1.1-1.1-1.3
Bone: elastic displacement0.30.31.00.00.11.00.60.50.30.70.20.40.60.50.50.7
Bone: elastic work0.91.12.60.30.61.61.11.00.91.30.81.01.11.01.21.2
Bone: endosteal estimation1.84.05.12.02.22.31.92.02.02.02.02.01.81.82.01.9
Bone: endosteal perimeter0.30.71.41.21.11.10.90.80.90.70.70.90.40.60.70.6
Epididymis fat weight0.31.12.71.30.81.10.91.61.30.60.91.01.00.91.00.5
Delta time in closed arm before/after self-admin4.74.44.92.12.12.12.21.82.02.22.12.22.12.02.12.2
Delta time in open arm before/after self-admin0.10.10.2-0.3-0.1-0.2-0.2-0.4-0.2-0.2-0.3-0.2-0.3-0.0-0.2-0.2
Diff in mean of infusions in LGA sessions1.51.82.3-1.2-1.4-1.4-1.5-1.5-1.4-1.2-1.3-1.3-1.3-1.1-1.3-1.3
Delay discount exponential model param0.50.51.00.20.70.81.00.70.70.80.70.80.60.40.60.8
Extinction: sum of active levers before priming1.01.11.7-0.9-0.9-1.1-1.1-1.3-1.1-1.0-1.0-1.1-0.8-1.0-1.0-1.1
Active lever presses in extinction session 61.61.62.8-1.4-1.1-1.7-1.3-1.5-1.3-1.3-1.1-1.3-1.1-0.9-1.1-1.3
Bone: final force2.54.05.72.02.21.92.02.42.11.92.01.91.92.11.91.8
Bone: final moment2.33.75.51.82.11.81.92.32.01.91.91.71.92.11.81.8
Food consumed during 24 hour testing period0.10.10.3-0.10.2-0.00.10.50.40.30.10.20.30.40.20.3
Glucose0.71.01.60.80.90.90.71.11.01.11.01.01.01.31.11.1
Heart weight0.40.50.80.90.70.80.90.70.60.90.50.80.60.70.70.8
Delay discount hyperbolic model param0.60.71.20.30.81.01.10.90.91.00.80.90.70.40.80.9
Intermittent access intake day 1-15 change0.20.41.30.40.61.01.1-0.10.30.70.50.70.50.40.60.7
Intermittent access intake escalation0.10.20.90.20.50.80.9-0.20.20.50.30.50.30.30.40.5
Intermittent access intake escalation 20.10.10.2-0.0-0.10.50.4-0.5-0.3-0.0-0.10.0-0.3-0.1-0.1-0.0
Intermitt. access day 1 inactive lever presses0.10.41.1-0.9-1.1-0.3-1.0-0.4-0.4-0.3-0.8-0.3-0.3-0.9-0.5-0.4
Intermitt. access day 15 inactive lever presses0.30.61.2-0.8-1.1-0.6-1.0-0.5-0.6-0.6-0.9-0.5-0.8-1.1-0.7-0.6
Intermitt. access escalation Index0.20.30.8-0.9-0.6-0.9-0.6-0.1-0.3-0.5-0.2-0.5-0.2-0.5-0.5-0.5
Intermittent access day 1 total infusions0.91.42.2-1.5-1.5-1.3-1.4-1.2-1.1-1.1-1.2-1.0-1.0-1.0-1.0-1.0
Intermittent access day 15 total infusions0.10.20.7-0.6-0.40.1-0.2-0.8-0.5-0.3-0.4-0.2-0.2-0.4-0.3-0.2
Intermittent access terminal intake (last 3 days)0.10.20.5-0.4-0.50.1-0.3-0.7-0.5-0.4-0.4-0.3-0.4-0.3-0.4-0.3
Intermittent access total infusions0.50.61.1-1.1-1.0-0.6-0.8-0.9-0.8-0.7-0.8-0.6-0.6-0.7-0.7-0.6
Intermittent access day 1 locomotion0.10.10.20.20.30.3-0.10.30.40.40.40.40.40.30.30.4
Intermittent access day 15 total locomotion0.20.30.60.60.80.80.60.10.40.70.50.70.50.40.60.7
Intermittent access total locomotion0.00.00.1-0.00.10.3-0.1-0.20.10.20.10.20.20.00.10.3
Intermittent access standard deviation0.51.11.81.10.81.41.01.01.00.90.91.01.01.21.00.9
Left kidney weight2.511.514.73.83.43.53.13.53.53.43.33.43.13.43.33.3
Right kidney weight5.022.928.05.34.64.84.75.15.04.74.74.84.54.74.84.6
Cocaine induced anxiety0.70.91.8-0.8-1.1-0.9-0.7-1.0-0.9-0.8-1.2-0.9-1.1-1.3-0.8-0.8
Post-drug Anxiety2.52.63.3-1.5-1.8-1.6-1.5-1.6-1.5-1.6-1.8-1.6-1.7-1.8-1.6-1.6
Baseline Anxiety0.00.00.20.10.10.1-0.20.20.0-0.10.20.00.30.4-0.0-0.0
Tail length0.41.51.91.31.31.41.31.01.21.31.11.30.91.11.31.4
Length with tail1.46.17.92.82.62.82.42.42.52.42.32.62.02.32.62.4
Length without tail3.511.313.33.63.53.62.93.53.43.23.23.43.23.43.43.1
Times rat made contact with spout3.64.14.9-2.0-2.0-2.2-1.8-1.9-1.9-2.1-1.9-2.0-2.1-2.1-2.1-2.1
Lifetime Intake0.40.51.0-1.0-1.0-0.6-0.7-0.7-0.7-0.7-0.8-0.5-0.6-0.6-0.6-0.5
Liver weight, left0.50.81.81.30.80.60.61.30.90.80.90.80.70.90.70.8
Liver weight, right0.81.42.71.71.41.21.01.51.31.01.21.20.91.01.00.9
Locomotor activity1.01.62.21.21.01.11.41.01.11.41.41.21.41.21.31.5
Locomotor testing distance0.50.91.41.00.60.90.90.90.81.11.10.91.10.91.01.2
Locomotor testing rearing1.22.53.91.61.61.51.41.41.31.71.71.51.51.51.52.0
Locomotion in novel chamber0.20.30.7-0.3-0.7-0.7-0.8-0.5-0.5-0.6-0.5-0.6-0.5-0.3-0.5-0.5
Locomotion in novel chamber post-restriction1.52.43.11.81.71.71.71.21.41.61.51.61.41.51.51.5
Fecal boli incidents, locomotor time 10.71.01.40.91.20.80.91.11.01.01.01.00.81.11.00.9
Change in fecal boli incidents, locomotor task4.64.56.02.22.02.02.12.02.22.22.12.12.52.12.12.1
Time >=10cm from walls, locomotor time 11.51.62.31.51.31.40.91.51.31.21.41.11.21.21.11.0
Bouts of movement, locomotor time 10.40.41.0-0.6-0.4-0.5-0.4-0.6-0.6-0.6-0.7-0.6-0.8-1.0-0.8-0.6
Total resting periods, locomotor time 10.20.30.6-0.6-0.3-0.4-0.3-0.3-0.4-0.5-0.5-0.5-0.6-0.8-0.6-0.5
Rest time, locomotor task time 10.50.61.70.60.70.60.81.30.90.70.80.80.60.70.70.7
Distance moved, locomotor task time 10.50.71.0-0.3-0.8-0.4-0.8-1.0-0.9-0.9-0.8-0.9-0.8-1.0-0.9-0.9
Vertical activity count, locomotor time 10.10.20.30.1-0.6-0.2-0.4-0.6-0.4-0.5-0.4-0.5-0.2-0.4-0.5-0.5
Time >=10cm from walls, locomotor time 26.79.911.43.42.93.02.93.33.23.13.33.13.33.13.13.1
Bouts of movement, locomotor time 20.40.60.8-0.9-0.6-0.9-0.7-0.7-0.8-0.7-0.9-0.7-0.7-0.8-0.7-0.7
Total resting periods, locomotor time 20.50.81.4-1.2-0.7-1.0-0.9-0.8-0.9-0.8-1.0-0.8-0.8-1.0-0.9-0.8
Rest time, locomotor task time 20.00.00.1-0.10.0-0.2-0.30.3-0.1-0.3-0.1-0.2-0.3-0.1-0.2-0.2
Distance moved, locomotor task time 20.70.81.51.20.71.21.00.90.90.80.90.90.90.60.80.8
Vertical activity count, locomotor time 20.60.81.10.90.60.80.80.91.01.00.90.91.10.80.80.9
Light reinforcement 11.53.74.82.22.12.01.71.51.82.02.02.01.91.91.91.9
Light reinforcement 21.11.82.71.21.61.30.91.21.21.31.41.41.51.51.41.3
Bone: marrow area2.04.55.52.12.32.32.02.12.22.12.22.11.91.92.12.0
Bone: maximum diameter0.20.40.70.60.80.70.90.60.70.70.50.70.40.40.60.7
Bone: maximum force1.32.43.61.21.51.51.51.91.71.61.51.51.51.61.41.5
Bone: maximum moment1.22.13.21.01.41.41.41.81.51.61.41.31.41.51.31.5
Mean time between licks in bursts0.20.51.2-0.7-0.3-0.9-1.1-0.6-0.6-0.7-0.5-0.7-0.6-0.5-0.7-0.7
Mean num. licks in bursts0.30.51.0-0.9-0.3-0.6-0.4-1.0-0.8-0.6-0.9-0.7-0.7-0.5-0.6-0.7
Cd content in liver0.20.20.6-0.5-0.1-0.8-0.6-0.3-0.6-0.3-0.2-0.7-0.3-0.2-0.5-0.3
Co content in liver0.50.60.70.90.80.80.80.70.80.60.70.80.80.80.70.5
Cu content in liver0.00.00.2-0.30.30.40.3-0.0-0.1-0.00.00.20.2-0.00.30.1
Fe content in liver2.32.84.82.22.01.91.71.51.61.51.71.71.41.31.61.4
K content in liver1.41.41.9-0.7-1.1-1.3-1.4-1.2-1.1-1.4-1.2-1.0-1.3-1.2-1.1-1.3
Mg content in liver2.32.43.0-1.3-1.5-1.7-1.7-1.4-1.4-1.7-1.6-1.4-1.6-1.6-1.5-1.7
Mn content in liver0.20.30.5-0.0-0.4-0.3-0.5-0.5-0.2-0.7-0.6-0.1-0.7-0.7-0.4-0.7
Na content in liver0.10.10.30.2-0.00.40.1-0.6-0.1-0.1-0.30.2-0.2-0.20.2-0.1
Rb content in liver0.10.10.4-0.70.1-0.6-0.0-0.0-0.2-0.0-0.0-0.20.20.0-0.10.2
Se content in liver2.12.53.9-1.1-1.3-2.0-1.9-1.4-1.4-1.7-1.6-1.4-1.6-1.6-1.6-1.7
Sr content in liver0.90.81.2-1.0-0.6-0.9-1.0-1.1-1.1-0.8-0.7-1.0-0.8-0.8-0.9-0.5
Zn content in liver0.10.10.5-0.20.1-0.5-0.70.1-0.3-0.20.1-0.3-0.10.1-0.1-0.1
Bone: minimum diameter1.42.53.01.51.71.71.51.71.61.71.61.51.41.61.41.6
Time in familiar zone, hab. session 10.80.71.0-0.6-0.8-0.7-0.5-0.9-1.0-0.9-0.9-0.9-0.9-0.9-0.9-0.9
Time in novel zone, hab. session 12.32.32.71.51.41.61.31.41.61.61.51.61.61.51.61.6
Total zone transitions, hab. session 13.24.55.4-1.7-2.3-1.9-2.0-2.2-2.2-2.1-2.2-2.1-2.3-2.2-2.1-2.1
Total locomotion distance, hab. session 11.72.32.7-1.5-1.6-1.4-1.4-1.6-1.6-1.5-1.6-1.5-1.6-1.6-1.5-1.5
Locomotion velocity, hab. session 12.02.83.2-1.7-1.8-1.7-1.5-1.7-1.7-1.7-1.8-1.6-1.6-1.6-1.6-1.7
Time in familiar zone, hab. session 20.50.50.7-0.8-0.8-0.5-0.6-0.8-0.7-0.7-0.7-0.6-0.8-0.8-0.6-0.7
Time in novel zone, hab. session 20.30.30.50.50.60.40.50.40.50.60.60.50.70.60.50.6
Total zone transitions, hab. session 20.10.10.2-0.1-0.5-0.2-0.3-0.3-0.3-0.2-0.3-0.2-0.4-0.3-0.1-0.3
Total locomotion distance, hab. session 20.71.01.4-1.2-1.0-1.1-1.1-1.0-1.0-0.9-1.0-0.9-0.9-0.9-0.9-0.9
Locomotion velocity, hab. session 21.01.31.6-1.3-1.2-1.3-1.3-1.1-1.2-1.1-1.1-1.1-1.1-1.1-1.1-1.1
Novel to familiar place preference ratio1.31.41.70.91.21.31.11.01.11.31.21.21.21.21.31.3
Novelty place preference1.31.41.91.01.21.41.20.91.11.31.11.21.21.21.31.3
Time in novel zone, NPP test1.21.31.70.91.21.31.10.81.01.21.11.21.21.11.21.2
Total zone transitions, NPP test0.50.71.0-0.4-0.8-0.9-0.9-0.7-0.9-0.9-0.8-0.8-1.0-0.8-0.7-0.9
Total locomotion distance, NPP test0.10.10.3-0.3-0.3-0.5-0.4-0.2-0.3-0.3-0.2-0.2-0.3-0.2-0.1-0.3
Locomotion velocity, NPP test0.20.20.5-0.4-0.5-0.7-0.5-0.4-0.5-0.5-0.4-0.4-0.5-0.4-0.3-0.5
Intraocular pressure1.52.23.41.41.31.81.51.31.51.51.41.61.41.41.61.4
Delta distance traveled before/after self-admin0.50.60.8-0.4-0.6-0.8-0.7-0.7-0.8-0.9-0.7-0.8-0.9-0.5-0.8-0.9
Delta ambulatory time before/after self-admin0.40.50.7-0.3-0.6-0.8-0.7-0.5-0.7-0.8-0.6-0.7-0.8-0.4-0.8-0.8
Parametrial fat weight0.41.01.50.71.20.31.00.81.11.01.01.01.21.11.11.1
Pavlov. Cond. lever latency0.50.60.90.70.90.91.00.50.70.70.80.80.80.60.70.7
Pavlov. Cond. magazine entry latency0.40.50.8-0.8-0.9-0.7-0.7-0.7-0.6-0.5-0.7-0.6-0.8-0.6-0.5-0.5
Pavlov. Cond. change in total contacts0.00.00.10.20.1-0.00.00.30.30.2-0.10.20.00.30.30.1
Pavlov. Cond. index score0.10.20.4-0.4-0.6-0.6-0.6-0.2-0.3-0.3-0.4-0.4-0.5-0.3-0.3-0.3
Pavlov. Cond. latency score0.00.10.2-0.2-0.4-0.4-0.40.0-0.1-0.1-0.2-0.2-0.3-0.0-0.1-0.1
Pavlov. Cond. lever contacts0.20.20.5-0.4-0.7-0.6-0.6-0.2-0.3-0.4-0.5-0.4-0.4-0.3-0.3-0.4
Pavlov. Cond. magazine entry number0.60.81.11.01.10.90.90.90.70.70.90.81.00.80.70.7
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.30.00.0-0.2-0.4-0.5-0.3-0.4-0.4-0.4-0.2-0.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.3-0.5-0.5-0.5-0.2-0.3-0.3-0.3-0.4-0.5-0.2-0.3-0.2
Pavlov. Cond. response bias1.01.21.5-1.1-1.2-1.1-1.2-1.1-1.0-1.0-1.2-1.0-1.2-1.1-1.0-1.0
Pavlov. Cond. lever latency1.41.93.01.31.51.51.71.11.41.51.11.51.31.21.41.5
Pavlov. Cond. magazine entry latency0.10.10.30.10.20.0-0.20.50.30.30.50.30.40.50.50.4
Pavlov. Cond. change in total contacts1.01.63.5-1.2-1.2-1.4-1.9-0.8-1.2-1.3-0.8-1.5-1.0-0.8-1.3-1.3
Pavlov. Cond. index score0.40.61.6-0.7-0.8-1.0-1.3-0.5-0.7-0.8-0.5-0.8-0.6-0.4-0.7-0.7
Pavlov. Cond. latency score0.30.41.2-0.6-0.7-0.8-1.1-0.3-0.5-0.6-0.3-0.6-0.5-0.3-0.5-0.6
Pavlov. Cond. lever contacts1.21.72.7-1.2-1.4-1.4-1.6-1.1-1.3-1.4-1.0-1.4-1.2-1.1-1.3-1.4
Pavlov. Cond. magazine entry number0.20.20.4-0.3-0.3-0.10.0-0.6-0.4-0.4-0.7-0.4-0.6-0.6-0.6-0.5
Pavlov. Cond. intertrial magazine entries1.42.13.1-1.4-1.7-1.2-1.1-1.4-1.3-1.5-1.8-1.3-1.6-1.6-1.4-1.6
Pavlov. Cond. lever-magazine prob. diff.0.30.51.4-0.6-0.8-0.9-1.2-0.4-0.6-0.7-0.4-0.8-0.5-0.3-0.6-0.6
Pavlov. Cond. response bias0.60.81.8-0.9-1.0-1.2-1.4-0.5-0.9-0.9-0.5-1.0-0.7-0.5-0.8-0.8
Time in closed arm before self-admin0.00.00.1-0.2-0.10.0-0.20.1-0.0-0.1-0.0-0.10.0-0.0-0.0-0.1
Time in closed arm after self-admin1.11.21.60.81.21.21.00.91.01.11.21.21.31.01.11.2
Time in open arm before self-admin0.00.00.0-0.10.1-0.20.1-0.10.0-0.0-0.0-0.0-0.0-0.1-0.00.0
Time in open arm after self-admin0.40.40.6-0.7-0.6-0.7-0.3-0.7-0.6-0.6-0.8-0.6-0.7-0.4-0.6-0.6
Bone: periosteal estimation1.43.03.61.51.91.91.71.91.81.81.71.71.61.61.71.7
Bone: periosteal perimeter0.10.20.40.60.70.60.60.50.60.40.30.50.20.30.30.3
Bone: post-yield work0.10.20.60.40.50.0-0.10.60.30.40.80.10.20.60.10.5
Progressive ratio test 1 active lever presses0.10.10.4-0.2-0.4-0.4-0.6-0.2-0.2-0.4-0.3-0.3-0.3-0.1-0.3-0.3
Progressive ratio test 1 breakpoint0.10.10.3-0.1-0.3-0.3-0.5-0.2-0.1-0.3-0.2-0.2-0.2-0.0-0.2-0.2
Progressive ratio test 1 inactive lever presses0.20.31.1-1.0-1.0-0.5-0.7-0.6-0.4-0.3-0.8-0.3-0.4-0.5-0.3-0.1
Progressive ratio test 2 active lever presses0.40.50.9-0.9-0.8-0.3-0.6-0.9-0.7-0.7-0.7-0.6-0.6-0.6-0.5-0.5
Progressive ratio test 2 breakpoint0.50.61.1-1.0-0.9-0.4-0.7-1.1-0.8-0.8-0.8-0.7-0.7-0.7-0.6-0.6
Progressive ratio test 2 inactive lever presses1.42.23.3-1.7-1.8-1.2-1.5-1.5-1.5-1.5-1.6-1.4-1.5-1.6-1.3-1.3
Incentive Sensitization - Responses0.40.61.5-1.1-0.7-0.2-0.5-1.2-0.9-0.7-0.8-0.7-0.7-0.7-0.6-0.5
Incentive Sensitization - Breakpoint0.30.41.2-1.0-0.6-0.1-0.3-1.1-0.8-0.6-0.7-0.6-0.6-0.6-0.5-0.4
Sum of active levers in priming session hrs 5-60.50.50.8-0.7-0.6-0.7-0.6-0.9-0.7-0.7-0.6-0.7-0.6-0.6-0.7-0.7
Progressive ratio0.40.60.90.80.80.70.90.90.80.70.70.70.70.80.80.7
Food seeking constrained by brief footshock0.10.10.20.0-0.4-0.20.1-0.2-0.3-0.4-0.3-0.3-0.4-0.1-0.3-0.3
Seeking ratio, punishment vs. effort0.10.10.3-0.2-0.5-0.3-0.2-0.4-0.4-0.3-0.3-0.3-0.3-0.4-0.4-0.3
Retroperitoneal fat weight0.41.62.31.21.50.61.21.51.41.21.41.31.31.41.21.1
Reaction time number correct0.10.20.3-0.5-0.4-0.3-0.5-0.3-0.4-0.3-0.5-0.5-0.4-0.3-0.4-0.2
Reaction time mean minus median0.00.10.3-0.3-0.50.1-0.3-0.5-0.4-0.2-0.5-0.1-0.6-0.30.0-0.2
Reaction time mean minus median AUC0.10.20.5-0.4-0.70.0-0.6-0.7-0.5-0.3-0.7-0.2-0.7-0.5-0.1-0.2
Reaction time num false alarms0.20.20.8-0.9-0.8-0.6-0.3-0.3-0.2-0.3-0.5-0.5-0.3-0.5-0.4-0.3
Reaction time num false alarms AUC0.30.41.0-1.0-1.0-0.6-0.5-0.5-0.5-0.5-0.7-0.7-0.5-0.8-0.7-0.5
Reaction time trials correct on left0.10.20.3-0.5-0.4-0.3-0.5-0.3-0.4-0.3-0.5-0.5-0.4-0.3-0.4-0.2
Reaction time trials on left0.10.20.4-0.5-0.5-0.4-0.6-0.4-0.5-0.4-0.5-0.5-0.5-0.4-0.5-0.3
Reaction time mean0.40.60.80.70.80.80.50.70.70.90.80.90.60.80.90.9
Reaction time mean AUC0.40.70.90.80.90.80.60.80.80.90.80.90.70.80.90.9
Median of all reaction times0.71.01.41.01.20.90.71.01.01.11.11.01.01.01.11.1
Reaction time omissions0.91.42.6-0.8-1.1-1.1-1.6-0.8-1.1-1.3-1.2-1.1-1.4-1.2-1.1-1.2
Reaction time false alarm rate0.10.10.3-0.5-0.5-0.20.0-0.2-0.1-0.1-0.2-0.2-0.1-0.5-0.2-0.1
Reaction time premature initiation rate0.20.30.80.20.40.90.60.40.50.50.40.70.50.60.70.5
Reaction time premature initiations0.10.10.50.00.20.70.40.20.30.30.10.40.20.40.50.4
Std. dev. reaction times0.00.00.1-0.1-0.00.1-0.1-0.2-0.10.0-0.10.1-0.3-0.00.20.1
Reaction time trials completed0.10.20.4-0.5-0.5-0.4-0.6-0.4-0.5-0.4-0.5-0.5-0.5-0.4-0.5-0.3
Reaction time trials AUC0.10.20.4-0.4-0.4-0.3-0.6-0.3-0.4-0.3-0.5-0.5-0.4-0.2-0.4-0.2
Run reversals in cocaine runway, females0.00.00.10.10.30.30.1-0.00.10.2-0.00.1-0.0-0.10.00.1
Run reversals in cocaine runway, males0.20.20.5-0.5-0.3-0.1-0.7-0.6-0.4-0.3-0.5-0.3-0.4-0.4-0.3-0.3
Latency to leave start box in cocaine runway0.20.20.4-0.2-0.4-0.3-0.5-0.6-0.7-0.6-0.5-0.5-0.5-0.5-0.4-0.5
Latency to leave start box in cocaine runway, F0.50.50.9-0.6-0.6-0.5-0.9-0.8-0.9-0.8-0.7-0.7-0.8-0.7-0.6-0.8
Latency to leave start box in cocaine runway, M0.20.20.40.60.20.30.60.40.40.40.20.30.60.40.40.4
Std. dev. time between licks in bursts2.43.23.91.61.81.51.41.81.91.81.91.81.92.01.91.8
Total sessions with >9 infusions1.01.21.6-1.3-1.2-0.9-1.2-1.2-1.1-1.0-1.1-1.0-1.1-0.7-1.0-1.0
Short access day 1 total inactive lever presses1.82.43.1-1.2-1.6-0.9-1.6-1.5-1.7-1.7-1.7-1.6-1.8-1.7-1.4-1.5
Short access day 10 total inactive lever presses0.71.62.6-1.4-1.6-1.2-1.5-1.1-1.1-1.1-1.5-1.1-1.2-1.2-1.1-1.1
Short access day 1 total infusions0.50.61.1-1.0-1.0-0.9-0.8-0.9-0.8-0.8-0.9-0.7-0.7-0.5-0.6-0.5
Short access day 10 total infusions1.01.32.2-1.4-1.5-1.2-1.0-1.3-1.0-0.9-1.3-0.9-1.1-1.0-1.0-0.9
Short access total infusions0.60.81.4-1.1-1.2-1.0-1.0-0.8-0.8-0.8-1.0-0.7-0.8-0.6-0.8-0.7
Short access day 1 locomotion0.20.30.5-0.7-0.6-0.4-0.6-0.5-0.5-0.4-0.5-0.4-0.5-0.5-0.5-0.4
Short access day 10 total locomotion0.50.91.21.10.90.90.61.01.01.01.11.01.11.10.90.9
Short access total locomotion0.10.10.40.20.10.6-0.10.20.20.30.30.30.20.20.10.3
One hour access (0.3 mA shock)5.76.58.3-2.3-2.4-2.0-2.6-2.9-2.7-2.6-2.6-2.5-2.7-2.7-2.6-2.4
Compulsive drug intake1.01.12.0-0.9-0.9-1.0-1.2-1.0-1.1-1.1-1.1-1.1-1.0-1.4-1.1-0.9
One hour access (shock baseline)1.21.93.1-1.4-1.5-1.1-1.3-1.8-1.4-1.3-1.5-1.2-1.4-1.5-1.3-1.1
Social response proportion0.20.30.50.70.50.20.30.70.70.40.70.40.50.70.40.3
Social responses0.10.10.20.4-0.2-0.4-0.30.1-0.0-0.2-0.0-0.3-0.2-0.2-0.3-0.3
Social time0.60.81.7-0.6-0.5-0.7-1.1-0.8-0.8-0.9-1.0-0.8-1.0-1.3-0.9-0.8
Soleus weight0.61.72.31.31.40.81.21.51.41.21.41.21.21.51.31.2
Bone: stiffness0.50.81.21.11.10.60.91.11.00.70.90.90.80.90.70.7
Tibialis anterior weight0.82.83.4-1.8-1.5-1.8-1.8-1.5-1.5-1.8-1.8-1.7-1.6-1.6-1.6-1.8
Time to tail flick, vehicle, before self-admin0.20.20.40.3-0.1-0.6-0.4-0.4-0.5-0.4-0.3-0.5-0.70.0-0.3-0.5
Time to tail flick, vehicle, after self-admin0.00.10.20.00.30.20.4-0.10.10.30.30.30.20.30.20.3
Time to tail flick, test, before self-admin0.30.30.6-0.8-0.4-0.7-0.6-0.5-0.6-0.5-0.4-0.5-0.2-0.8-0.3-0.4
Time to tail flick, test, after self-admin0.90.91.3-0.9-1.0-0.7-1.2-0.6-1.0-1.1-0.8-1.0-1.2-1.0-1.0-1.0
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.5-0.20.30.3-0.20.10.20.00.20.3-0.10.10.2
Delta time to tail flick, test, before/after SA0.30.30.90.80.40.70.40.90.60.40.50.50.20.70.40.3
Tibia length2.05.67.22.52.22.52.62.32.52.32.12.72.12.02.52.3
Ambulatory time before self-admin0.20.20.60.50.70.70.4-0.00.30.50.40.40.50.40.50.5
Ambulatory time after self-admin0.10.10.40.1-0.1-0.1-0.3-0.6-0.4-0.4-0.4-0.4-0.4-0.0-0.4-0.4
Bone: tissue strength0.40.40.70.30.70.80.70.40.50.80.40.60.50.50.50.8
Total heroin consumption1.82.13.0-1.3-1.3-1.4-1.5-1.7-1.5-1.4-1.4-1.5-1.4-1.3-1.4-1.4
Bone: trabecular number0.10.20.6-0.7-0.8-0.4-0.7-0.2-0.2-0.4-0.2-0.4-0.3-0.3-0.4-0.5
Bone: trabecular spacing0.91.22.01.31.31.11.41.10.91.20.91.01.01.11.01.1
Bone: trabecular thickness0.10.20.60.10.30.2-0.10.80.40.30.60.10.40.60.10.3
Bone: trabecular tissue density0.10.20.60.1-0.20.10.10.70.50.30.20.30.40.70.40.2
Water consumed over 24 hours1.01.42.4-1.5-1.2-1.5-1.5-0.7-0.9-1.1-0.9-1.1-1.0-1.1-1.2-1.1
Number of responses in last shaping day0.50.50.91.00.70.80.80.40.60.80.50.90.70.50.70.8