Rpl23

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Rpl23 0.03 0.02 1.2e-03 0.02 0.02 0.01 0.02 2.1e-03 4.5e-03 8.1e-03 4.5e-03
2 Brain gene expression Rpl23 0.02 0.02 8.1e-03 0.01 0.01 0 0.01 2.7e-02 3.3e-02 2.3e-01 6.1e-02
3 NAcc gene expression Rpl23 0.02 0.02 7.0e-03 0.01 0.01 0 0.01 1.4e-02 2.4e-02 1.4e-01 4.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density2.03.34.32.11.51.8
Area under the delay curve0.80.91.00.90.91.0
BMI with tail1.13.75.9-2.4-1.9-1.2
BMI without tail0.10.20.3-0.5-0.3-0.4
Body weight5.221.827.7-5.3-4.4-4.3
Weight adjusted by age0.20.30.4-0.3-0.5-0.6
Bone surface0.00.00.10.0-0.3-0.1
Bone volume0.10.10.20.50.00.3
Breakpoint value in progressive ratio session1.11.21.5-1.2-1.1-1.0
Number of licking bursts0.50.60.80.90.70.6
Context. condit. distance diff. score0.60.70.8-0.8-0.9-0.8
Locomotion velocity, session 10.70.80.8-0.9-0.9-0.8
Locomotion distance, session 13.54.55.5-2.3-2.0-2.0
Locomotion velocity, session 20.80.91.2-0.8-1.0-1.1
Locomotion distance, session 21.11.51.8-1.2-1.1-1.3
Locomotion velocity, session 30.10.10.2-0.4-0.2-0.2
Locomotion distance, session 30.70.81.0-0.8-0.8-1.0
Stereotopy head waving bouts, day 33.94.64.82.22.12.1
Stereotopy head waving duration, day 30.81.01.00.91.01.0
Locomotion velocity, session 70.50.61.0-1.0-0.5-0.6
Locomotion distance, session 70.10.10.2-0.4-0.2-0.5
Stereotopy head waving bouts, day 70.80.91.41.20.90.8
Stereotopy head waving duration, day 70.20.20.40.60.30.3
Locomotion velocity, session 86.67.98.7-2.9-2.8-2.7
Locomotion distance, session 81.92.83.0-1.6-1.6-1.7
Degree of sensitization distance0.20.20.2-0.5-0.3-0.3
Degree of sensitization stereotypy1.41.52.11.51.11.1
Conditioned locomotion0.10.10.20.30.40.4
Cocaine response after cond. corrected2.32.63.21.81.51.5
Cocaine response after cond. not corrected3.53.94.92.21.91.8
Cocaine response before conditioning0.70.91.21.11.00.7
Saline control response0.60.81.00.61.01.0
Bone: connectivity density2.64.15.02.21.91.9
Bone: cortical apparent density4.55.98.32.92.32.0
Bone: cortical area0.10.20.40.60.40.3
Bone: cortical porosity1.01.11.40.91.21.0
Bone: cortical porosity1.51.62.11.01.51.2
Bone: cortical thickness1.22.03.31.81.31.0
Bone: cortical thickness4.85.66.82.62.42.0
Bone: cortical tissue density4.55.98.32.92.32.0
Condit. Reinf. active minus inactive responses0.30.40.50.70.60.5
Condit. Reinf. active-inactive response ratio0.80.91.00.81.01.0
Condit. Reinf. active responses0.60.71.11.00.70.8
Condit. Reinf. inactive responses0.60.70.91.00.70.7
Incentive salience index mean1.21.51.81.31.21.1
Condit. Reinf. lever presses1.11.41.51.21.21.1
Condit. Reinf. active minus inactive responses0.91.11.40.81.11.2
Condit. Reinf. active-inactive response ratio0.40.40.60.50.70.8
Condit. Reinf. active responses1.31.82.21.11.41.5
Condit. Reinf. inactive responses2.53.13.41.61.81.8
Condit. Reinf. lever presses0.10.10.10.20.30.3
Condit. Reinf. lever reinforcers received1.21.72.11.11.41.5
Conditioned reinforcement - actives2.02.02.80.91.51.7
Conditioned reinforcement - inactives2.12.33.50.91.91.7
Conditioned locomotion1.72.03.01.01.51.7
Patch foraging indifference point 0 sec1.62.53.11.41.61.7
Patch foraging indifference point AUC0.40.40.80.0-0.9-0.7
Delay disc. indifference point, 0s delay1.21.31.41.11.21.1
Delay disc. indifference point, 16s delay0.60.60.91.00.50.8
Delay disc. indifference point, 2s delay2.52.73.11.51.81.7
Delay disc. indifference point, 24s delay0.10.10.10.3-0.3-0.1
Delay disc. indifference point, 4s delay0.40.40.60.80.60.5
Delay disc. indifference point, 8s delay0.91.01.20.71.11.1
Indifference point function ln k0.00.10.10.00.30.3
Indifference point function log k0.00.10.10.00.30.3
Patch foraging total patch changes 0 sec1.01.62.01.11.31.4
Patch foraging total patch changes 12 sec4.66.06.22.52.42.5
Patch foraging total patch changes 18 sec0.40.60.91.00.30.8
Patch foraging total patch changes 24 sec1.72.13.41.81.11.3
Patch foraging total patch changes 6 sec1.31.92.31.51.11.4
Patch foraging time to switch 0 sec0.10.20.30.20.50.6
Patch foraging water rate 0 sec0.10.20.3-0.2-0.6-0.5
Patch foraging water rate 12 sec0.40.71.1-0.6-0.8-1.0
Patch foraging water rate 18 sec0.30.50.60.70.80.5
Patch foraging water rate 24 sec0.20.30.50.40.60.7
Patch foraging water rate 6 sec0.40.61.31.10.60.5
Seeking ratio, delayed vs. immediate footshock0.00.00.00.2-0.2-0.1
Distance traveled before self-admin0.10.10.3-0.60.30.0
Distance traveled after self-admin1.51.72.3-1.5-1.2-1.2
Extensor digitorum longus weight7.529.732.4-5.7-5.4-5.2
Bone: elastic displacement0.10.10.10.10.40.3
Bone: elastic work0.00.00.00.10.1-0.1
Bone: endosteal estimation1.94.15.0-2.2-2.0-1.8
Bone: endosteal perimeter1.53.24.3-2.1-1.7-1.5
Epididymis fat weight0.30.70.9-1.0-0.8-0.7
Delta time in closed arm before/after self-admin3.73.63.8-1.9-2.0-1.8
Delta time in open arm before/after self-admin0.10.10.30.20.50.3
Diff in mean of infusions in LGA sessions0.20.20.5-0.7-0.1-0.1
Delay discount exponential model param0.40.40.5-0.7-0.6-0.7
Extinction: sum of active levers before priming1.31.31.5-1.1-1.1-1.2
Active lever presses in extinction session 60.10.10.20.40.2-0.2
Bone: final force1.21.92.41.61.41.2
Bone: final moment1.01.72.01.41.31.2
Food consumed during 24 hour testing period1.11.31.6-1.0-1.1-1.3
Glucose0.50.70.90.91.00.6
Heart weight2.83.95.0-2.2-1.8-1.8
Delay discount hyperbolic model param0.70.70.8-0.8-0.9-0.9
Intermittent access intake day 1-15 change0.10.10.10.10.30.3
Intermittent access intake escalation0.10.10.1-0.00.40.3
Intermittent access intake escalation 20.20.20.3-0.3-0.5-0.5
Intermitt. access day 1 inactive lever presses1.11.21.60.61.21.3
Intermitt. access day 15 inactive lever presses3.13.44.01.91.72.0
Intermitt. access escalation Index0.70.60.7-0.8-0.8-0.7
Intermittent access day 1 total infusions0.00.00.10.20.20.3
Intermittent access day 15 total infusions0.20.20.30.20.50.5
Intermittent access terminal intake (last 3 days)0.10.20.30.20.40.5
Intermittent access total infusions0.00.00.0-0.20.20.2
Intermittent access day 1 locomotion0.30.30.40.50.60.6
Intermittent access day 15 total locomotion0.30.30.40.60.50.5
Intermittent access total locomotion0.60.70.90.70.90.9
Intermittent access standard deviation0.10.10.20.20.50.3
Left kidney weight2.87.79.3-2.6-2.7-3.1
Right kidney weight0.71.92.9-1.0-1.3-1.7
Cocaine induced anxiety2.32.63.1-1.5-1.8-1.6
Post-drug Anxiety0.00.00.0-0.1-0.1-0.0
Baseline Anxiety4.24.55.41.72.32.2
Tail length1.44.26.7-1.8-1.6-2.6
Length with tail5.219.222.6-4.3-4.0-4.8
Length without tail4.59.911.0-3.3-3.1-3.0
Times rat made contact with spout0.80.91.41.20.90.8
Lifetime Intake0.00.00.0-0.20.10.1
Liver weight, left0.10.20.3-0.4-0.4-0.6
Liver weight, right0.00.10.10.2-0.1-0.4
Locomotor activity0.61.01.21.00.91.1
Locomotor testing distance3.35.56.62.12.32.6
Locomotor testing rearing4.46.78.42.92.42.4
Locomotion in novel chamber3.44.18.83.01.31.4
Locomotion in novel chamber post-restriction0.70.91.10.90.81.0
Fecal boli incidents, locomotor time 10.30.40.5-0.2-0.7-0.7
Change in fecal boli incidents, locomotor task0.10.00.10.20.30.0
Time >=10cm from walls, locomotor time 10.90.91.30.91.10.7
Bouts of movement, locomotor time 10.30.30.7-0.9-0.3-0.2
Total resting periods, locomotor time 10.40.51.1-1.0-0.4-0.3
Rest time, locomotor task time 10.10.10.30.10.50.3
Distance moved, locomotor task time 10.10.10.20.40.20.4
Vertical activity count, locomotor time 10.10.10.1-0.2-0.3-0.3
Time >=10cm from walls, locomotor time 22.02.12.61.61.51.1
Bouts of movement, locomotor time 20.20.20.30.10.50.6
Total resting periods, locomotor time 20.10.10.3-0.20.40.5
Rest time, locomotor task time 20.80.91.3-1.2-0.7-0.9
Distance moved, locomotor task time 20.00.00.0-0.0-0.2-0.1
Vertical activity count, locomotor time 20.00.00.1-0.3-0.0-0.1
Light reinforcement 12.34.24.91.82.22.2
Light reinforcement 20.71.01.01.01.01.0
Bone: marrow area1.83.84.7-2.2-1.9-1.8
Bone: maximum diameter0.00.00.00.20.10.1
Bone: maximum force0.00.10.20.40.30.0
Bone: maximum moment0.00.00.10.30.3-0.0
Mean time between licks in bursts1.01.31.9-1.4-1.1-1.0
Mean num. licks in bursts0.00.00.0-0.00.20.1
Cd content in liver0.10.10.20.30.40.3
Co content in liver1.31.51.7-1.1-1.3-1.3
Cu content in liver0.91.11.1-1.0-1.1-1.0
Fe content in liver1.72.02.2-1.5-1.3-1.4
K content in liver0.20.20.30.50.30.3
Mg content in liver0.20.20.30.50.40.4
Mn content in liver0.30.40.70.80.50.5
Na content in liver0.30.30.40.50.50.6
Rb content in liver1.51.82.51.01.41.6
Se content in liver1.82.23.11.81.41.2
Sr content in liver0.30.30.4-0.4-0.5-0.7
Zn content in liver2.22.42.91.21.71.7
Bone: minimum diameter0.50.91.1-1.0-0.9-1.1
Time in familiar zone, hab. session 10.50.50.80.60.90.6
Time in novel zone, hab. session 10.80.70.90.90.71.0
Total zone transitions, hab. session 12.23.13.7-1.8-1.6-1.9
Total locomotion distance, hab. session 10.00.00.0-0.20.1-0.2
Locomotion velocity, hab. session 10.50.70.9-0.9-0.7-0.9
Time in familiar zone, hab. session 20.60.60.90.51.00.9
Time in novel zone, hab. session 20.00.00.10.30.00.1
Total zone transitions, hab. session 20.60.70.9-1.0-0.7-0.9
Total locomotion distance, hab. session 20.00.10.2-0.4-0.1-0.1
Locomotion velocity, hab. session 20.20.20.4-0.7-0.3-0.4
Novel to familiar place preference ratio2.22.32.7-1.2-1.6-1.7
Novelty place preference1.51.51.9-0.9-1.3-1.4
Time in novel zone, NPP test0.50.50.8-0.4-0.8-0.9
Total zone transitions, NPP test0.30.40.5-0.7-0.5-0.7
Total locomotion distance, NPP test0.00.00.10.10.20.1
Locomotion velocity, NPP test0.20.30.3-0.6-0.4-0.5
Intraocular pressure1.72.42.6-1.6-1.5-1.5
Delta distance traveled before/after self-admin1.31.41.9-1.1-1.4-1.1
Delta ambulatory time before/after self-admin0.40.40.7-0.6-0.8-0.5
Parametrial fat weight0.91.72.40.71.51.5
Pavlov. Cond. lever latency3.13.94.2-2.0-2.0-1.9
Pavlov. Cond. magazine entry latency9.612.414.13.83.53.3
Pavlov. Cond. change in total contacts6.67.19.53.12.52.3
Pavlov. Cond. index score8.410.711.73.43.23.1
Pavlov. Cond. latency score6.68.39.33.02.82.8
Pavlov. Cond. lever contacts2.73.23.31.81.81.7
Pavlov. Cond. magazine entry number12.115.017.6-4.2-3.7-3.7
Pavlov. Cond. intertrial magazine entries1.51.81.9-1.3-1.4-1.3
Pavlov. Cond. lever-magazine prob. diff.9.511.813.03.63.43.3
Pavlov. Cond. response bias9.511.512.63.53.43.3
Pavlov. Cond. lever latency0.20.30.4-0.6-0.4-0.6
Pavlov. Cond. magazine entry latency0.00.00.1-0.0-0.2-0.3
Pavlov. Cond. change in total contacts0.60.81.00.80.91.0
Pavlov. Cond. index score0.10.20.30.50.40.3
Pavlov. Cond. latency score0.10.10.20.40.20.2
Pavlov. Cond. lever contacts0.81.11.21.11.01.1
Pavlov. Cond. magazine entry number0.10.20.2-0.4-0.4-0.3
Pavlov. Cond. intertrial magazine entries1.31.71.9-1.4-1.2-1.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.30.30.2
Pavlov. Cond. response bias1.01.31.41.21.11.2
Time in closed arm before self-admin2.02.33.41.11.51.8
Time in closed arm after self-admin0.40.50.7-0.8-0.8-0.3
Time in open arm before self-admin3.23.53.7-1.8-1.9-1.9
Time in open arm after self-admin0.40.40.7-0.8-0.3-0.7
Bone: periosteal estimation0.20.30.4-0.6-0.6-0.6
Bone: periosteal perimeter0.60.91.1-1.1-0.9-1.0
Bone: post-yield work0.91.21.3-1.1-1.0-1.1
Progressive ratio test 1 active lever presses1.11.11.31.11.11.0
Progressive ratio test 1 breakpoint1.11.21.31.11.21.0
Progressive ratio test 1 inactive lever presses1.51.62.10.91.41.4
Progressive ratio test 2 active lever presses1.01.01.21.01.11.0
Progressive ratio test 2 breakpoint0.70.80.90.90.90.8
Progressive ratio test 2 inactive lever presses0.00.00.00.1-0.1-0.0
Incentive Sensitization - Responses0.90.91.11.10.90.8
Incentive Sensitization - Breakpoint0.80.81.21.10.90.8
Sum of active levers in priming session hrs 5-60.10.10.20.40.2-0.1
Progressive ratio0.10.10.20.20.40.4
Food seeking constrained by brief footshock0.30.30.60.50.70.5
Seeking ratio, punishment vs. effort0.00.00.10.20.1-0.1
Retroperitoneal fat weight0.00.10.4-0.6-0.2-0.2
Reaction time number correct0.50.71.4-1.2-0.7-0.7
Reaction time mean minus median0.10.10.1-0.20.30.3
Reaction time mean minus median AUC0.81.01.40.61.21.1
Reaction time num false alarms0.60.81.01.01.00.7
Reaction time num false alarms AUC0.50.60.70.80.90.7
Reaction time trials correct on left0.50.71.4-1.2-0.7-0.7
Reaction time trials on left0.50.71.3-1.2-0.6-0.6
Reaction time mean0.10.10.10.30.20.4
Reaction time mean AUC0.00.00.10.20.10.3
Median of all reaction times0.30.40.70.80.40.6
Reaction time omissions0.81.01.20.91.11.0
Reaction time false alarm rate1.01.31.71.31.11.0
Reaction time premature initiation rate0.60.81.10.71.00.9
Reaction time premature initiations0.10.10.2-0.20.40.2
Std. dev. reaction times0.10.20.20.10.50.5
Reaction time trials completed0.50.71.3-1.2-0.6-0.6
Reaction time trials AUC0.40.51.0-1.0-0.5-0.5
Run reversals in cocaine runway, females2.42.32.4-1.6-1.4-1.5
Run reversals in cocaine runway, males0.80.70.80.80.90.9
Latency to leave start box in cocaine runway2.52.73.2-1.8-1.7-1.5
Latency to leave start box in cocaine runway, F1.92.13.1-1.8-1.4-1.2
Latency to leave start box in cocaine runway, M0.70.71.0-0.5-1.0-0.9
Std. dev. time between licks in bursts0.10.10.2-0.4-0.4-0.3
Total sessions with >9 infusions0.70.81.00.81.00.8
Short access day 1 total inactive lever presses1.61.72.41.01.41.5
Short access day 10 total inactive lever presses0.40.41.0-1.0-0.5-0.2
Short access day 1 total infusions0.10.10.10.20.40.3
Short access day 10 total infusions0.00.00.10.2-0.1-0.0
Short access total infusions0.00.00.0-0.1-0.1-0.1
Short access day 1 locomotion2.52.73.11.81.71.5
Short access day 10 total locomotion1.71.92.01.31.41.4
Short access total locomotion0.60.70.90.61.00.9
One hour access (0.3 mA shock)0.10.10.2-0.10.20.4
Compulsive drug intake0.00.00.1-0.10.20.2
One hour access (shock baseline)0.20.20.40.00.40.6
Social response proportion0.20.20.50.00.70.4
Social responses0.20.20.40.20.60.4
Social time0.00.00.0-0.10.20.1
Soleus weight0.61.71.91.41.21.3
Bone: stiffness0.10.10.10.30.40.0
Tibialis anterior weight1.34.54.5-2.1-2.1-2.1
Time to tail flick, vehicle, before self-admin0.00.00.10.40.10.0
Time to tail flick, vehicle, after self-admin0.10.10.20.50.30.3
Time to tail flick, test, before self-admin0.80.80.9-0.9-0.8-0.8
Time to tail flick, test, after self-admin0.10.10.20.3-0.3-0.5
Delta time to tail flick, vehicle, before/after SA0.50.50.60.60.80.6
Delta time to tail flick, test, before/after SA1.61.42.31.51.10.9
Tibia length0.82.42.9-1.3-1.7-1.6
Ambulatory time before self-admin0.20.20.6-0.8-0.1-0.3
Ambulatory time after self-admin3.23.53.8-1.9-1.8-1.8
Bone: tissue strength0.50.50.7-0.5-0.8-0.7
Total heroin consumption0.20.20.60.80.10.0
Bone: trabecular number4.77.48.83.02.62.6
Bone: trabecular spacing0.70.91.4-1.2-0.7-0.9
Bone: trabecular thickness0.00.00.10.3-0.10.1
Bone: trabecular tissue density0.00.00.10.10.30.1
Water consumed over 24 hours0.00.00.00.10.10.2
Number of responses in last shaping day0.10.10.4-0.1-0.2-0.6