Hub : Genes

Rnf4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Rnf4	0.06	0.04	1.5e-08	0.06	0.06	0.06	0.06	5.0e-07	1.1e-07	5.0e-07	6.4e-07
2	Brain	intron excision ratio	chr14_80639985_80647017	0.03	0.03	1.8e-03	0.01	0.01	0	0.01	1.3e-02	2.4e-02	3.5e-01	6.2e-02
3	Liver	gene expression	Rnf4	0.02	0.01	8.1e-03	0.01	0.01	0	0	2.5e-02	4.3e-02	1.5e-01	7.3e-02
4	BLA	intron excision ratio	chr14_80639985_80647011	0.28	0.17	3.7e-03	0	0.05	0.03	0.03	2.8e-01	1.0e-03	7.8e-03	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.7	1.2	1.9	1.4	-0.9	1.1	1.0
Area under the delay curve	0.8	0.9	2.7	-0.5	0.6	-0.6	-1.6
BMI with tail	2.0	6.7	9.4	-3.0	2.4	-1.6	-3.1
BMI without tail	1.3	4.1	6.2	-2.5	2.1	-1.0	-2.2
Body weight	5.5	24.1	30.4	-5.5	5.1	-4.9	-4.0
Weight adjusted by age	2.5	3.8	4.4	-2.1	2.0	-1.8	-1.9
Bone surface	0.2	0.3	0.7	-0.2	0.6	-0.8	-0.2
Bone volume	0.0	0.1	0.1	0.3	-0.2	0.1	0.3
Breakpoint value in progressive ratio session	0.1	0.1	0.1	0.2	-0.3	0.3	0.0
Number of licking bursts	1.2	1.9	3.6	-1.4	1.5	-1.9	-0.1
Context. condit. distance diff. score	0.3	0.3	0.8	0.6	-0.9	0.3	0.3
Locomotion velocity, session 1	1.1	1.2	1.5	1.2	-1.0	1.1	1.1
Locomotion distance, session 1	0.3	0.4	0.7	0.8	-0.2	0.8	0.3
Locomotion velocity, session 2	4.6	5.3	7.6	2.8	-1.8	1.9	2.6
Locomotion distance, session 2	1.8	2.5	5.2	2.3	-1.1	1.8	0.7
Locomotion velocity, session 3	0.1	0.1	0.3	0.5	-0.3	-0.1	-0.2
Locomotion distance, session 3	0.1	0.1	0.3	-0.0	0.4	-0.3	-0.6
Stereotopy head waving bouts, day 3	1.6	1.8	2.9	0.8	-1.7	1.7	0.9
Stereotopy head waving duration, day 3	1.3	1.5	2.8	0.7	-1.6	1.7	0.5
Locomotion velocity, session 7	1.2	1.3	4.4	-0.8	0.4	-2.1	0.0
Locomotion distance, session 7	0.1	0.2	0.4	0.5	-0.2	-0.6	-0.1
Stereotopy head waving bouts, day 7	0.9	1.1	2.2	-1.3	0.5	-0.4	-1.5
Stereotopy head waving duration, day 7	1.7	2.1	3.2	-1.8	1.0	-1.1	-1.7
Locomotion velocity, session 8	1.9	2.3	4.0	1.5	-2.0	0.8	1.5
Locomotion distance, session 8	1.5	2.1	3.6	1.9	-1.4	1.3	1.2
Degree of sensitization distance	1.2	1.2	2.2	1.1	-1.1	0.3	1.5
Degree of sensitization stereotypy	1.8	1.9	2.7	-1.6	1.1	-1.0	-1.6
Conditioned locomotion	0.7	0.8	2.2	-0.2	0.4	-0.8	-1.5
Cocaine response after cond. corrected	1.2	1.4	2.4	1.3	-1.2	1.5	0.2
Cocaine response after cond. not corrected	0.5	0.5	1.0	0.8	-0.7	1.0	0.1
Cocaine response before conditioning	0.7	0.9	1.3	-1.0	1.1	-1.2	0.1
Saline control response	0.2	0.3	0.4	0.5	-0.4	0.5	0.7
Bone: connectivity density	0.3	0.5	1.2	1.1	-0.5	0.7	0.5
Bone: cortical apparent density	0.4	0.5	1.1	-0.7	-0.2	0.7	-1.1
Bone: cortical area	5.5	8.5	11.8	-3.0	3.4	-3.2	-1.5
Bone: cortical porosity	0.4	0.4	0.9	0.7	-1.0	0.3	0.3
Bone: cortical porosity	0.0	0.0	0.1	0.2	-0.3	0.2	-0.2
Bone: cortical thickness	3.8	6.3	9.4	-2.6	3.1	-2.4	-1.8
Bone: cortical thickness	0.6	0.7	2.5	-0.2	-0.2	-0.4	-1.6
Bone: cortical tissue density	0.4	0.6	1.2	-0.6	-0.3	0.8	-1.1
Condit. Reinf. active minus inactive responses	1.4	1.5	2.6	1.2	-1.4	1.6	0.3
Condit. Reinf. active-inactive response ratio	2.8	3.0	5.0	1.8	-1.7	2.2	0.9
Condit. Reinf. active responses	0.6	0.8	1.3	0.7	-1.1	1.1	0.1
Condit. Reinf. inactive responses	1.0	1.2	2.1	-1.3	0.8	-1.5	-0.5
Incentive salience index mean	0.2	0.2	0.4	0.3	-0.6	0.6	-0.1
Condit. Reinf. lever presses	0.5	0.7	1.0	-1.0	0.6	-0.9	-0.8
Condit. Reinf. active minus inactive responses	0.3	0.4	0.6	-0.7	0.6	-0.8	0.4
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.2	0.2	-0.5	0.4	-0.5
Condit. Reinf. active responses	0.2	0.2	0.7	0.2	-0.4	-0.2	0.9
Condit. Reinf. inactive responses	0.4	0.5	1.2	0.4	-0.8	-0.0	1.1
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.7	0.6	-0.6	-0.4
Condit. Reinf. lever reinforcers received	0.0	0.1	0.2	-0.0	-0.1	-0.4	0.3
Conditioned reinforcement - actives	0.5	0.9	1.6	-0.8	0.8	-0.8	-1.3
Conditioned reinforcement - inactives	0.5	0.8	0.9	-1.0	1.0	-1.0	-0.6
Conditioned locomotion	1.1	1.4	1.5	-1.2	1.2	-1.2	-1.2
Patch foraging indifference point 0 sec	0.1	0.2	0.3	-0.1	-0.6	0.4	0.5
Patch foraging indifference point AUC	0.4	0.5	0.8	0.6	-0.4	0.9	0.9
Delay disc. indifference point, 0s delay	2.5	2.8	9.6	-0.6	0.7	-0.7	-3.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	-0.3	0.4	-0.3
Delay disc. indifference point, 2s delay	0.6	0.7	2.7	0.1	0.1	-0.0	-1.6
Delay disc. indifference point, 24s delay	0.8	0.9	3.1	-0.3	0.4	-0.3	-1.7
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.4	-0.3	0.3	-0.6
Delay disc. indifference point, 8s delay	0.8	0.9	1.0	-1.0	1.0	-1.0	-0.8
Indifference point function ln k	0.3	0.5	0.8	0.6	-0.9	0.3	0.8
Indifference point function log k	0.3	0.5	0.8	0.6	-0.9	0.3	0.8
Patch foraging total patch changes 0 sec	0.1	0.1	0.3	-0.2	-0.4	0.3	0.5
Patch foraging total patch changes 12 sec	0.2	0.2	0.5	-0.7	0.3	-0.4	-0.4
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	-0.1	-0.5	0.5	0.3
Patch foraging total patch changes 24 sec	0.1	0.2	0.6	-0.2	-0.0	0.4	-0.8
Patch foraging total patch changes 6 sec	0.2	0.2	0.8	-0.3	-0.1	0.4	0.9
Patch foraging time to switch 0 sec	1.5	3.1	5.8	-1.4	1.6	-1.4	-2.4
Patch foraging water rate 0 sec	0.5	1.0	3.2	-0.6	0.2	-0.5	1.8
Patch foraging water rate 12 sec	0.2	0.5	1.3	0.2	-0.4	0.8	1.1
Patch foraging water rate 18 sec	0.2	0.3	0.9	-0.3	-0.0	0.4	0.9
Patch foraging water rate 24 sec	0.6	0.8	2.5	-0.8	0.2	-0.0	1.6
Patch foraging water rate 6 sec	0.5	0.8	1.5	-1.2	0.7	-0.6	0.9
Seeking ratio, delayed vs. immediate footshock	2.8	3.4	4.9	1.7	-1.7	1.7	2.2
Distance traveled before self-admin	0.9	1.2	1.8	1.3	-1.3	1.1	0.4
Distance traveled after self-admin	0.3	0.4	1.3	0.3	-0.2	0.1	-1.2
Extensor digitorum longus weight	1.7	6.7	12.0	-3.5	2.6	-2.5	-1.4
Bone: elastic displacement	1.1	1.3	2.5	-1.0	1.6	-1.3	-0.3
Bone: elastic work	3.3	4.3	6.2	-2.3	2.5	-2.3	-0.6
Bone: endosteal estimation	0.9	1.9	4.8	-1.3	1.1	-2.2	0.2
Bone: endosteal perimeter	1.0	2.2	4.5	-1.3	1.5	-2.1	0.0
Epididymis fat weight	1.7	5.9	7.6	-2.8	2.1	-2.4	-2.4
Delta time in closed arm before/after self-admin	0.6	0.6	0.8	0.9	-0.9	0.9	-0.0
Delta time in open arm before/after self-admin	1.6	1.6	1.7	-1.3	1.3	-1.3	-1.1
Diff in mean of infusions in LGA sessions	0.8	1.0	1.5	1.2	-1.1	1.1	-0.4
Delay discount exponential model param	0.6	0.7	2.3	0.4	-0.5	0.5	1.5
Extinction: sum of active levers before priming	1.0	1.1	1.4	-1.0	1.0	-1.0	-1.2
Active lever presses in extinction session 6	0.4	0.4	1.7	-0.1	0.1	0.0	-1.3
Bone: final force	4.8	7.7	11.4	-2.8	3.1	-3.4	-1.3
Bone: final moment	3.9	6.2	8.8	-2.6	2.9	-3.0	-0.9
Food consumed during 24 hour testing period	0.4	0.6	2.0	0.1	-0.5	-0.1	1.4
Glucose	0.6	0.9	2.0	0.1	-0.6	-1.1	1.4
Heart weight	1.2	1.8	2.8	-1.3	1.6	-1.7	-0.4
Delay discount hyperbolic model param	0.6	0.7	2.3	0.3	-0.4	0.4	1.5
Intermittent access intake day 1-15 change	2.2	4.5	5.8	2.4	-2.3	2.3	1.2
Intermittent access intake escalation	1.5	3.0	3.9	2.0	-1.9	1.9	1.0
Intermittent access intake escalation 2	2.7	3.1	3.4	1.9	-1.8	1.8	1.5
Intermitt. access day 1 inactive lever presses	0.1	0.5	0.6	0.7	-0.8	0.8	0.7
Intermitt. access day 15 inactive lever presses	0.4	0.8	0.8	0.9	-0.9	0.9	0.9
Intermitt. access escalation Index	0.6	0.9	1.2	1.1	-1.0	1.0	0.7
Intermittent access day 1 total infusions	1.1	1.7	3.2	-1.1	1.1	-1.1	-1.8
Intermittent access day 15 total infusions	0.0	0.0	0.2	0.1	-0.0	0.0	-0.4
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.1	0.3	-0.3	0.3	0.1
Intermittent access total infusions	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.4
Intermittent access day 1 locomotion	0.8	1.0	1.3	-0.9	0.9	-0.9	-1.2
Intermittent access day 15 total locomotion	0.4	0.7	1.9	-0.6	0.6	-0.6	-1.4
Intermittent access total locomotion	0.1	0.1	0.3	-0.1	0.1	-0.1	-0.5
Intermittent access standard deviation	0.3	0.6	0.8	0.9	-0.8	0.8	0.5
Left kidney weight	3.9	18.1	24.2	-4.9	4.9	-4.2	-2.7
Right kidney weight	3.3	15.0	18.4	-4.3	4.3	-3.6	-3.2
Cocaine induced anxiety	0.6	0.8	1.0	0.9	-0.8	0.8	1.0
Post-drug Anxiety	0.2	0.2	0.3	0.5	-0.4	0.4	-0.5
Baseline Anxiety	2.8	3.3	7.1	-1.4	1.4	-1.4	-2.7
Tail length	0.8	3.0	4.8	-1.9	2.2	-1.9	-0.1
Length with tail	3.1	13.5	19.0	-4.2	4.0	-4.4	-1.3
Length without tail	2.7	8.8	12.9	-3.3	3.0	-3.6	-1.5
Times rat made contact with spout	1.5	1.8	2.8	1.2	-1.4	0.9	1.7
Lifetime Intake	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.3
Liver weight, left	0.4	0.7	1.1	-0.9	0.7	-1.1	-0.6
Liver weight, right	2.1	3.7	6.5	-2.5	2.0	-1.4	-1.5
Locomotor activity	0.6	0.9	3.3	-0.2	0.1	-0.6	1.8
Locomotor testing distance	0.4	0.7	1.2	-1.1	0.5	-1.1	0.1
Locomotor testing rearing	0.7	1.4	2.4	-1.5	1.0	-1.5	0.3
Locomotion in novel chamber	0.3	0.4	0.7	0.8	-0.8	0.7	0.1
Locomotion in novel chamber post-restriction	0.1	0.2	0.5	0.4	-0.1	-0.1	-0.7
Fecal boli incidents, locomotor time 1	0.4	0.6	0.9	0.7	-0.8	0.7	1.0
Change in fecal boli incidents, locomotor task	0.5	0.5	0.9	0.7	-0.5	0.5	0.9
Time >=10cm from walls, locomotor time 1	2.5	2.7	5.2	-1.4	1.3	-1.3	-2.3
Bouts of movement, locomotor time 1	0.4	0.4	1.3	-0.4	0.3	-0.2	-1.2
Total resting periods, locomotor time 1	0.4	0.4	1.4	-0.4	0.3	-0.3	-1.2
Rest time, locomotor task time 1	1.2	1.5	2.2	-1.5	1.3	-1.5	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.3	-0.1	0.5	0.2
Vertical activity count, locomotor time 1	0.5	1.2	1.7	1.3	-1.1	1.2	0.8
Time >=10cm from walls, locomotor time 2	0.6	0.8	0.9	-0.9	0.9	-1.0	-0.8
Bouts of movement, locomotor time 2	0.1	0.1	0.3	0.1	-0.2	0.2	-0.6
Total resting periods, locomotor time 2	0.1	0.2	0.6	-0.2	0.2	-0.1	-0.8
Rest time, locomotor task time 2	0.9	1.2	1.6	-1.2	1.2	-1.2	-0.3
Distance moved, locomotor task time 2	0.4	0.4	0.7	0.8	-0.6	0.8	0.2
Vertical activity count, locomotor time 2	1.2	1.7	2.4	1.6	-1.4	1.4	0.6
Light reinforcement 1	1.5	3.6	5.4	-2.3	2.0	-1.8	-1.3
Light reinforcement 2	1.9	2.9	4.6	-2.1	1.8	-1.8	-0.9
Bone: marrow area	0.8	1.8	4.6	-1.2	1.0	-2.1	0.1
Bone: maximum diameter	3.0	5.7	8.3	-2.8	2.9	-2.3	-0.9
Bone: maximum force	3.1	5.5	8.3	-2.5	2.5	-2.9	-0.9
Bone: maximum moment	2.4	4.2	6.0	-2.3	2.3	-2.4	-0.4
Mean time between licks in bursts	1.1	2.6	5.5	1.4	-1.3	1.2	2.3
Mean num. licks in bursts	2.8	4.4	5.9	2.2	-2.3	2.4	1.2
Cd content in liver	0.1	0.1	0.3	0.3	-0.1	-0.1	0.6
Co content in liver	0.7	0.8	2.3	-0.4	0.8	-1.5	-0.4
Cu content in liver	0.6	0.8	1.6	1.3	-1.0	0.6	0.4
Fe content in liver	2.8	3.4	5.6	2.4	-2.3	1.6	0.5
K content in liver	0.4	0.4	1.0	0.1	0.6	-0.4	-1.0
Mg content in liver	1.8	1.8	3.6	-1.1	1.9	-1.1	-1.1
Mn content in liver	0.4	0.4	0.8	0.7	-0.5	0.4	0.9
Na content in liver	0.4	0.4	0.5	0.6	-0.7	-0.3	-0.7
Rb content in liver	0.5	0.5	1.3	-0.3	0.7	-1.1	-0.5
Se content in liver	0.3	0.3	1.0	0.2	-0.4	1.0	-0.1
Sr content in liver	1.3	1.1	2.1	-1.5	1.3	-0.9	-0.2
Zn content in liver	0.3	0.3	0.4	-0.4	-0.5	0.7	0.6
Bone: minimum diameter	1.3	2.4	4.6	-1.4	1.7	-2.2	0.1
Time in familiar zone, hab. session 1	0.6	0.6	0.8	0.9	-0.8	0.9	0.4
Time in novel zone, hab. session 1	0.2	0.2	0.6	-0.8	0.6	-0.2	0.0
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.5	-0.4	0.3	0.3
Total locomotion distance, hab. session 1	0.5	0.7	1.1	1.0	-0.8	0.6	0.8
Locomotion velocity, hab. session 1	0.1	0.2	0.5	0.7	-0.2	-0.1	0.4
Time in familiar zone, hab. session 2	3.3	3.5	5.4	2.0	-2.3	2.1	0.5
Time in novel zone, hab. session 2	5.2	5.3	8.6	-2.7	2.9	-2.1	-0.6
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.2	-0.1	0.2	0.3
Total locomotion distance, hab. session 2	0.1	0.2	0.6	0.0	-0.1	0.3	0.8
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.1	-0.1	0.2	0.6
Novel to familiar place preference ratio	0.0	0.0	0.1	0.4	-0.1	0.1	-0.1
Novelty place preference	0.0	0.0	0.0	0.2	0.1	-0.0	0.0
Time in novel zone, NPP test	0.0	0.0	0.0	0.1	0.1	-0.0	0.1
Total zone transitions, NPP test	0.0	0.1	0.1	0.3	-0.3	0.3	-0.2
Total locomotion distance, NPP test	0.3	0.4	0.6	0.8	-0.6	0.8	-0.1
Locomotion velocity, NPP test	0.5	0.6	1.1	1.0	-0.8	0.9	-0.2
Intraocular pressure	0.2	0.3	0.7	-0.7	0.9	-0.2	-0.2
Delta distance traveled before/after self-admin	1.2	1.3	2.9	-0.8	0.9	-0.8	-1.7
Delta ambulatory time before/after self-admin	0.1	0.1	0.5	0.2	-0.1	0.2	-0.7
Parametrial fat weight	0.1	0.3	0.5	0.7	-0.6	0.7	-0.2
Pavlov. Cond. lever latency	0.8	1.0	1.6	1.1	-0.8	1.3	0.8
Pavlov. Cond. magazine entry latency	1.0	1.3	1.8	0.9	-1.3	1.3	1.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.1	-0.1	0.2	-0.2
Pavlov. Cond. index score	0.1	0.1	0.5	0.2	-0.7	0.2	0.0
Pavlov. Cond. latency score	0.0	0.1	0.2	-0.0	-0.5	-0.1	-0.1
Pavlov. Cond. lever contacts	0.5	0.6	1.2	-0.8	0.6	-1.1	-0.6
Pavlov. Cond. magazine entry number	1.3	1.7	2.5	-1.2	1.6	-1.4	-0.9
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.5	-0.7	0.7	-0.2	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.2	0.1	-0.4	0.1	-0.0
Pavlov. Cond. response bias	0.2	0.2	0.4	0.4	-0.6	0.5	0.3
Pavlov. Cond. lever latency	0.6	0.9	1.1	-0.8	1.1	-0.8	-1.0
Pavlov. Cond. magazine entry latency	1.3	1.6	2.0	-1.3	1.4	-1.4	-0.8
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	-0.3	0.1	0.0
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	-0.2	0.0	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.1	-0.2	0.0	0.2
Pavlov. Cond. lever contacts	0.9	1.3	1.7	1.2	-1.3	1.0	1.0
Pavlov. Cond. magazine entry number	1.3	1.7	2.6	1.6	-1.3	1.4	0.5
Pavlov. Cond. intertrial magazine entries	0.7	1.1	1.7	1.2	-1.3	0.7	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.2	-0.2	-0.1	0.2
Pavlov. Cond. response bias	0.1	0.1	0.1	0.2	-0.3	0.2	0.3
Time in closed arm before self-admin	0.1	0.1	0.1	-0.4	0.3	-0.3	0.3
Time in closed arm after self-admin	0.3	0.3	0.5	0.6	-0.7	0.7	0.3
Time in open arm before self-admin	0.1	0.1	0.2	-0.4	0.4	-0.5	0.1
Time in open arm after self-admin	1.5	1.7	2.1	-1.4	1.4	-1.4	-0.8
Bone: periosteal estimation	3.1	6.5	11.3	-2.6	2.7	-3.4	-0.8
Bone: periosteal perimeter	3.9	6.8	10.5	-2.6	2.9	-3.2	-1.3
Bone: post-yield work	0.9	1.3	2.4	0.8	-1.6	1.1	1.0
Progressive ratio test 1 active lever presses	0.9	1.1	1.1	-1.1	1.1	-1.1	-1.0
Progressive ratio test 1 breakpoint	0.9	1.1	1.1	-1.0	1.0	-1.0	-1.0
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.5	-0.1	0.2	-0.2	-0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.6	-0.2	0.2	-0.2	-0.8
Progressive ratio test 2 inactive lever presses	0.4	0.7	1.0	-0.7	0.8	-0.8	-1.0
Incentive Sensitization - Responses	0.1	0.1	0.2	0.3	-0.2	0.2	-0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.2	-0.2	0.2	-0.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	1.0	0.0	-0.1	0.2	-1.0
Progressive ratio	0.2	0.3	0.5	-0.4	0.6	-0.7	-0.4
Food seeking constrained by brief footshock	1.6	2.0	3.2	-1.4	1.4	-1.8	-1.1
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.3
Retroperitoneal fat weight	0.6	2.5	4.7	-1.3	1.4	-1.2	-2.2
Reaction time number correct	0.6	1.2	3.0	-1.1	0.4	-0.6	1.7
Reaction time mean minus median	0.6	1.5	1.9	1.3	-1.4	1.2	0.8
Reaction time mean minus median AUC	0.1	0.1	0.4	-0.3	0.2	-0.2	-0.6
Reaction time num false alarms	1.8	2.5	5.8	-1.2	1.4	-1.0	-2.4
Reaction time num false alarms AUC	2.2	3.4	7.0	-1.6	1.6	-1.2	-2.7
Reaction time trials correct on left	0.6	1.2	3.0	-1.1	0.4	-0.6	1.7
Reaction time trials on left	0.6	1.1	3.1	-1.0	0.3	-0.5	1.8
Reaction time mean	0.6	1.0	1.9	1.4	-1.0	1.0	-0.0
Reaction time mean AUC	0.6	0.9	1.8	1.3	-1.0	1.0	-0.1
Median of all reaction times	0.5	0.7	1.5	1.2	-0.7	0.8	-0.3
Reaction time omissions	0.5	0.7	1.5	0.7	-0.9	1.2	0.2
Reaction time false alarm rate	2.4	3.3	9.9	-0.9	1.3	-0.7	-3.1
Reaction time premature initiation rate	0.1	0.1	0.5	-0.2	-0.0	0.2	-0.7
Reaction time premature initiations	0.1	0.2	0.6	-0.8	0.1	-0.1	0.2
Std. dev. reaction times	0.4	0.8	1.2	1.0	-1.1	1.1	-0.0
Reaction time trials completed	0.6	1.1	3.1	-1.0	0.3	-0.5	1.8
Reaction time trials AUC	0.6	1.2	3.4	-1.0	0.3	-0.4	1.9
Run reversals in cocaine runway, females	1.0	1.0	1.3	1.1	-1.0	0.7	-1.1
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.5	0.6	-0.3	-0.5
Latency to leave start box in cocaine runway	1.3	1.5	1.9	-1.2	1.2	-1.4	-1.2
Latency to leave start box in cocaine runway, F	2.6	3.0	3.2	-1.8	1.7	-1.8	-1.6
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.0	-0.0	-0.2	0.1
Std. dev. time between licks in bursts	0.3	0.5	1.3	0.6	-0.4	-0.1	1.2
Total sessions with >9 infusions	0.1	0.2	0.4	-0.3	0.4	-0.4	-0.6
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.2	0.2	-0.2	0.1
Short access day 10 total inactive lever presses	0.8	1.9	4.1	1.0	-1.1	1.1	2.0
Short access day 1 total infusions	0.1	0.2	0.6	-0.1	0.2	-0.2	-0.8
Short access day 10 total infusions	0.0	0.0	0.0	-0.1	0.1	-0.1	0.2
Short access total infusions	0.0	0.0	0.0	0.0	0.0	-0.0	0.0
Short access day 1 locomotion	0.4	0.5	0.5	-0.7	0.7	-0.7	-0.7
Short access day 10 total locomotion	1.4	2.5	2.6	1.6	-1.6	1.6	1.5
Short access total locomotion	0.5	0.6	0.6	0.8	-0.8	0.8	0.7
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.2	0.2	-0.2	0.3
Compulsive drug intake	0.1	0.1	0.2	0.4	-0.4	0.4	0.1
One hour access (shock baseline)	0.0	0.0	0.0	-0.2	0.2	-0.2	0.1
Social response proportion	1.9	2.2	3.4	1.2	-1.3	1.5	1.8
Social responses	0.4	0.5	2.1	-0.1	-0.1	0.3	1.4
Social time	1.1	1.5	2.0	1.4	-1.4	1.1	1.0
Soleus weight	1.7	5.1	9.1	-3.0	2.7	-2.0	0.0
Bone: stiffness	1.2	2.0	4.3	-1.1	1.1	-2.1	-1.2
Tibialis anterior weight	0.9	3.2	5.8	-2.4	1.9	-1.6	-1.0
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.8	0.7	-0.7	0.9	-0.3
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.8	0.7	-0.6	0.9	0.1
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.3	0.3	-0.3	0.2
Time to tail flick, test, after self-admin	0.5	0.5	0.9	-0.6	0.6	-0.7	1.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.3	0.4	-0.3	0.1
Delta time to tail flick, test, before/after SA	0.3	0.3	1.1	-0.0	0.1	-0.0	1.0
Tibia length	1.5	4.1	6.4	-1.7	2.5	-2.4	-1.2
Ambulatory time before self-admin	0.5	0.8	1.2	1.1	-1.1	0.9	-0.2
Ambulatory time after self-admin	0.9	1.0	1.3	1.1	-1.1	0.9	-0.8
Bone: tissue strength	1.6	1.6	2.3	-1.3	1.5	-1.1	1.1
Total heroin consumption	0.3	0.3	0.6	-0.8	0.6	-0.6	-0.1
Bone: trabecular number	0.3	0.5	1.3	0.8	-0.3	1.1	0.4
Bone: trabecular spacing	1.2	1.6	2.8	-1.4	1.2	-1.7	-0.3
Bone: trabecular thickness	1.3	1.7	3.4	1.2	-1.9	1.2	0.5
Bone: trabecular tissue density	0.1	0.1	0.5	0.7	-0.3	0.2	0.1
Water consumed over 24 hours	1.8	2.5	6.3	1.2	-1.1	0.9	2.5
Number of responses in last shaping day	0.7	0.7	2.9	0.1	-0.0	0.0	-1.7