Hub : Genes

Rnf25

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Rnf25 0.02 0.03 3.4e-03 0.01 0.01 0.02 0.01 5.9e-03 6.5e-03 4.0e-03 6.8e-03
2 Liver gene expression Rnf25 0.04 0.04 4.2e-04 0.02 0.02 0.02 0.02 1.5e-03 1.4e-03 1.6e-03 3.5e-03
3 Adipose gene expression Rnf25 0.1 0.09 3.4e-09 0.07 0.07 0.07 0.07 4.7e-08 4.6e-08 7.7e-08 6.0e-08
4 BLA gene expression Rnf25 0.05 0.05 9.8e-03 0 0 0.01 0 1.9e-01 1.8e-01 1.2e-01 2.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.00.00.1-0.0-0.2-0.20.2
Area under the delay curve2.72.83.7-1.91.61.6-1.6
BMI with tail0.00.10.40.6-0.2-0.20.1
BMI without tail0.20.40.8-0.9-0.4-0.40.5
Body weight0.73.13.71.3-1.9-1.91.9
Weight adjusted by age1.51.86.3-2.50.50.5-0.4
Bone surface0.10.20.2-0.50.40.4-0.4
Bone volume0.00.00.0-0.1-0.1-0.10.2
Breakpoint value in progressive ratio session0.50.61.4-1.20.60.6-0.4
Number of licking bursts0.10.10.2-0.2-0.4-0.40.3
Context. condit. distance diff. score0.70.82.01.4-0.7-0.70.4
Locomotion velocity, session 10.10.20.30.0-0.4-0.40.6
Locomotion distance, session 10.10.10.3-0.50.00.00.2
Locomotion velocity, session 21.11.32.0-1.41.11.1-0.9
Locomotion distance, session 23.65.05.8-2.42.22.2-2.1
Locomotion velocity, session 31.72.02.0-1.41.41.4-1.4
Locomotion distance, session 30.00.00.1-0.30.00.00.2
Stereotopy head waving bouts, day 30.10.20.60.8-0.2-0.2-0.1
Stereotopy head waving duration, day 30.20.20.70.8-0.2-0.2-0.1
Locomotion velocity, session 70.30.30.7-0.90.50.5-0.3
Locomotion distance, session 70.10.20.2-0.30.40.4-0.5
Stereotopy head waving bouts, day 70.30.40.4-0.50.60.6-0.7
Stereotopy head waving duration, day 70.50.60.6-0.80.80.8-0.8
Locomotion velocity, session 81.72.02.2-1.41.41.4-1.5
Locomotion distance, session 80.30.50.8-0.40.70.7-0.9
Degree of sensitization distance0.00.00.10.20.10.1-0.3
Degree of sensitization stereotypy0.91.01.3-1.11.01.0-0.9
Conditioned locomotion0.30.40.70.8-0.6-0.60.3
Cocaine response after cond. corrected7.78.79.03.0-2.9-2.92.9
Cocaine response after cond. not corrected7.78.59.03.0-2.9-2.92.9
Cocaine response before conditioning0.10.10.1-0.10.40.4-0.3
Saline control response1.21.61.9-1.41.31.3-1.1
Bone: connectivity density0.10.20.20.4-0.4-0.40.4
Bone: cortical apparent density0.20.20.3-0.40.50.5-0.5
Bone: cortical area0.00.10.2-0.40.20.2-0.0
Bone: cortical porosity0.10.20.3-0.60.30.3-0.2
Bone: cortical porosity0.00.00.1-0.40.20.2-0.0
Bone: cortical thickness0.00.00.00.1-0.2-0.20.2
Bone: cortical thickness0.00.00.0-0.00.00.0-0.0
Bone: cortical tissue density0.20.30.3-0.40.50.5-0.6
Condit. Reinf. active minus inactive responses0.00.00.1-0.3-0.0-0.00.2
Condit. Reinf. active-inactive response ratio0.40.40.50.6-0.7-0.70.7
Condit. Reinf. active responses0.00.10.2-0.40.10.10.0
Condit. Reinf. inactive responses0.20.20.5-0.70.40.4-0.3
Incentive salience index mean0.00.00.2-0.40.10.10.0
Condit. Reinf. lever presses0.20.20.30.3-0.5-0.50.5
Condit. Reinf. active minus inactive responses0.10.10.2-0.0-0.4-0.40.5
Condit. Reinf. active-inactive response ratio0.60.61.51.2-0.7-0.70.4
Condit. Reinf. active responses0.20.31.0-1.00.20.20.1
Condit. Reinf. inactive responses2.42.96.1-2.51.51.5-1.0
Condit. Reinf. lever presses0.71.02.9-1.70.60.6-0.4
Condit. Reinf. lever reinforcers received0.20.30.9-0.90.40.4-0.1
Conditioned reinforcement - actives0.80.81.7-1.30.70.7-0.8
Conditioned reinforcement - inactives0.80.91.4-0.5-1.0-1.01.2
Conditioned locomotion2.73.38.4-2.91.31.3-1.2
Patch foraging indifference point 0 sec11.418.343.2-6.63.33.3-2.8
Patch foraging indifference point AUC1.41.65.82.40.30.3-0.6
Delay disc. indifference point, 0s delay0.80.91.1-0.71.01.0-1.0
Delay disc. indifference point, 16s delay0.80.91.9-1.40.70.7-0.7
Delay disc. indifference point, 2s delay4.34.74.8-2.12.22.2-2.2
Delay disc. indifference point, 24s delay0.10.10.4-0.6-0.1-0.10.2
Delay disc. indifference point, 4s delay1.81.92.0-1.31.41.4-1.4
Delay disc. indifference point, 8s delay3.63.85.5-2.31.81.8-1.8
Indifference point function ln k1.62.38.5-2.90.50.50.1
Indifference point function log k1.62.38.5-2.90.50.50.1
Patch foraging total patch changes 0 sec10.917.643.7-6.63.13.1-2.7
Patch foraging total patch changes 12 sec5.57.211.2-3.32.42.4-2.4
Patch foraging total patch changes 18 sec5.87.518.2-4.32.02.0-2.0
Patch foraging total patch changes 24 sec6.27.622.4-4.71.71.7-1.4
Patch foraging total patch changes 6 sec4.05.911.8-3.42.02.0-1.8
Patch foraging time to switch 0 sec0.61.01.1-1.0-1.0-1.00.9
Patch foraging water rate 0 sec0.10.10.10.30.30.3-0.2
Patch foraging water rate 12 sec0.50.81.1-0.51.11.1-0.8
Patch foraging water rate 18 sec0.00.00.10.30.10.1-0.1
Patch foraging water rate 24 sec1.62.25.6-2.41.01.0-1.0
Patch foraging water rate 6 sec0.50.81.1-1.00.90.9-0.7
Seeking ratio, delayed vs. immediate footshock0.10.10.30.60.00.0-0.2
Distance traveled before self-admin0.00.00.0-0.2-0.1-0.10.1
Distance traveled after self-admin2.12.32.4-1.61.51.5-1.5
Extensor digitorum longus weight0.10.50.7-0.80.70.7-0.6
Bone: elastic displacement3.23.63.9-2.01.91.9-1.9
Bone: elastic work0.70.91.0-1.00.90.9-0.9
Bone: endosteal estimation1.63.43.8-2.01.81.8-1.8
Bone: endosteal perimeter0.20.40.50.4-0.6-0.60.7
Epididymis fat weight1.22.73.70.2-1.9-1.91.9
Delta time in closed arm before/after self-admin0.90.91.8-1.40.60.6-1.0
Delta time in open arm before/after self-admin3.23.13.71.6-1.7-1.71.9
Diff in mean of infusions in LGA sessions0.60.70.8-0.70.90.9-0.8
Delay discount exponential model param2.32.43.01.7-1.5-1.51.5
Extinction: sum of active levers before priming0.20.20.3-0.40.50.5-0.5
Active lever presses in extinction session 60.40.40.6-0.40.80.8-0.5
Bone: final force1.11.82.3-1.51.31.3-1.2
Bone: final moment1.62.63.3-1.81.61.6-1.5
Food consumed during 24 hour testing period0.00.10.10.30.20.20.1
Glucose0.10.10.50.70.00.0-0.1
Heart weight0.60.91.51.20.70.7-1.1
Delay discount hyperbolic model param3.33.54.22.0-1.8-1.81.8
Intermittent access intake day 1-15 change1.91.96.2-2.50.70.7-0.5
Intermittent access intake escalation2.32.35.8-2.41.11.1-0.9
Intermittent access intake escalation 21.51.51.7-1.11.31.3-1.2
Intermitt. access day 1 inactive lever presses0.30.31.1-1.00.20.2-0.2
Intermitt. access day 15 inactive lever presses3.33.611.7-3.4-0.9-0.91.1
Intermitt. access escalation Index1.51.35.02.2-0.3-0.30.1
Intermittent access day 1 total infusions0.20.20.70.80.10.1-0.2
Intermittent access day 15 total infusions0.50.62.3-1.50.20.2-0.0
Intermittent access terminal intake (last 3 days)0.50.51.3-1.10.50.5-0.5
Intermittent access total infusions0.00.00.00.00.10.1-0.2
Intermittent access day 1 locomotion0.10.10.2-0.40.10.1-0.1
Intermittent access day 15 total locomotion3.03.211.9-3.50.70.7-0.3
Intermittent access total locomotion0.70.81.7-1.30.70.7-0.7
Intermittent access standard deviation3.03.112.0-3.50.50.5-0.3
Left kidney weight0.72.17.92.8-0.4-0.40.2
Right kidney weight1.02.99.43.1-0.9-0.90.8
Cocaine induced anxiety1.01.21.60.81.11.1-1.3
Post-drug Anxiety2.52.83.2-1.61.61.6-1.8
Baseline Anxiety1.61.76.6-2.6-0.2-0.20.3
Tail length1.23.65.20.0-2.1-2.12.3
Length with tail1.55.47.11.5-2.5-2.52.7
Length without tail1.22.56.22.5-1.2-1.21.1
Times rat made contact with spout0.10.10.2-0.50.10.1-0.1
Lifetime Intake0.10.10.2-0.40.20.2-0.3
Liver weight, left0.00.00.00.1-0.2-0.20.1
Liver weight, right2.94.96.61.5-2.3-2.32.6
Locomotor activity1.01.61.8-1.11.31.3-1.2
Locomotor testing distance2.74.45.2-1.82.32.3-2.1
Locomotor testing rearing5.07.78.7-2.42.92.9-2.7
Locomotion in novel chamber0.40.40.7-0.20.70.7-0.9
Locomotion in novel chamber post-restriction0.50.62.21.5-0.3-0.30.0
Fecal boli incidents, locomotor time 10.40.41.11.1-0.5-0.50.5
Change in fecal boli incidents, locomotor task0.10.10.1-0.00.30.3-0.3
Time >=10cm from walls, locomotor time 11.01.01.2-0.71.01.0-1.1
Bouts of movement, locomotor time 10.10.10.10.1-0.2-0.20.4
Total resting periods, locomotor time 10.00.00.0-0.10.20.2-0.1
Rest time, locomotor task time 10.10.10.3-0.50.20.2-0.3
Distance moved, locomotor task time 10.00.00.00.20.20.20.0
Vertical activity count, locomotor time 10.30.31.11.10.10.1-0.1
Time >=10cm from walls, locomotor time 20.50.60.9-1.00.70.7-0.7
Bouts of movement, locomotor time 20.40.51.7-1.30.20.2-0.1
Total resting periods, locomotor time 20.70.82.8-1.70.40.4-0.3
Rest time, locomotor task time 21.21.43.0-1.71.01.0-0.8
Distance moved, locomotor task time 20.00.00.00.20.00.00.0
Vertical activity count, locomotor time 21.11.23.01.7-0.8-0.80.8
Light reinforcement 12.95.36.2-2.12.32.3-2.5
Light reinforcement 21.41.92.8-0.61.51.5-1.7
Bone: marrow area1.63.53.8-2.01.81.8-1.8
Bone: maximum diameter0.30.60.90.6-0.8-0.80.9
Bone: maximum force1.83.13.8-2.01.71.7-1.6
Bone: maximum moment2.54.35.1-2.32.02.0-1.9
Mean time between licks in bursts2.33.24.8-2.21.61.6-1.7
Mean num. licks in bursts0.70.81.0-0.61.01.0-0.9
Cd content in liver1.31.51.7-1.11.21.2-1.3
Co content in liver2.93.43.8-1.71.91.9-2.0
Cu content in liver1.31.52.91.7-1.1-1.10.8
Fe content in liver0.00.00.10.3-0.1-0.10.0
K content in liver0.40.40.50.5-0.7-0.70.7
Mg content in liver0.00.00.00.1-0.1-0.10.0
Mn content in liver0.40.40.6-0.50.70.7-0.8
Na content in liver0.20.20.30.1-0.4-0.40.6
Rb content in liver0.60.70.90.9-0.8-0.80.7
Se content in liver1.01.21.41.0-1.1-1.11.2
Sr content in liver0.00.00.0-0.10.10.1-0.1
Zn content in liver0.10.20.30.5-0.4-0.40.3
Bone: minimum diameter0.81.52.5-1.61.11.1-0.9
Time in familiar zone, hab. session 14.23.94.32.1-2.0-2.01.9
Time in novel zone, hab. session 11.91.82.4-1.61.31.3-1.2
Total zone transitions, hab. session 10.30.40.6-0.80.60.6-0.6
Total locomotion distance, hab. session 10.10.10.2-0.40.30.3-0.4
Locomotion velocity, hab. session 10.20.30.4-0.60.50.5-0.5
Time in familiar zone, hab. session 22.42.52.61.6-1.6-1.61.5
Time in novel zone, hab. session 23.23.23.4-1.81.81.8-1.8
Total zone transitions, hab. session 20.00.00.00.2-0.1-0.10.1
Total locomotion distance, hab. session 20.00.00.00.1-0.0-0.0-0.1
Locomotion velocity, hab. session 20.10.20.20.5-0.4-0.40.4
Novel to familiar place preference ratio0.80.81.01.0-0.9-0.90.8
Novelty place preference0.30.30.40.6-0.5-0.50.4
Time in novel zone, NPP test0.10.10.10.4-0.3-0.30.2
Total zone transitions, NPP test0.00.00.00.1-0.0-0.0-0.1
Total locomotion distance, NPP test0.20.30.4-0.60.50.5-0.6
Locomotion velocity, NPP test0.20.30.4-0.60.50.5-0.6
Intraocular pressure1.11.62.0-0.81.31.3-1.4
Delta distance traveled before/after self-admin3.03.33.4-1.81.81.8-1.8
Delta ambulatory time before/after self-admin4.55.05.8-1.62.42.4-2.4
Parametrial fat weight1.32.53.31.1-1.7-1.71.8
Pavlov. Cond. lever latency0.50.60.9-1.00.70.7-0.6
Pavlov. Cond. magazine entry latency0.20.20.60.8-0.4-0.40.2
Pavlov. Cond. change in total contacts0.30.30.30.5-0.6-0.60.5
Pavlov. Cond. index score1.31.62.11.5-1.2-1.21.1
Pavlov. Cond. latency score0.91.11.41.2-1.0-1.00.9
Pavlov. Cond. lever contacts0.81.01.21.1-1.0-1.00.9
Pavlov. Cond. magazine entry number0.20.20.6-0.80.30.3-0.1
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.0-0.3-0.30.4
Pavlov. Cond. lever-magazine prob. diff.1.72.12.71.6-1.4-1.41.3
Pavlov. Cond. response bias0.70.81.61.3-0.8-0.80.6
Pavlov. Cond. lever latency1.11.43.61.9-0.9-0.90.7
Pavlov. Cond. magazine entry latency0.10.10.2-0.4-0.1-0.10.2
Pavlov. Cond. change in total contacts0.71.03.9-2.00.30.3-0.0
Pavlov. Cond. index score1.01.33.5-1.90.80.8-0.5
Pavlov. Cond. latency score0.60.82.4-1.50.60.6-0.3
Pavlov. Cond. lever contacts2.33.18.5-2.91.21.2-0.9
Pavlov. Cond. magazine entry number0.50.61.91.4-0.5-0.50.3
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.40.40.4-0.3
Pavlov. Cond. lever-magazine prob. diff.0.81.03.2-1.80.70.7-0.3
Pavlov. Cond. response bias2.33.18.3-2.91.31.3-1.0
Time in closed arm before self-admin2.93.39.83.1-1.0-1.01.1
Time in closed arm after self-admin0.70.71.1-0.60.80.8-1.0
Time in open arm before self-admin1.11.21.6-1.11.01.0-1.2
Time in open arm after self-admin1.11.21.60.6-1.2-1.21.3
Bone: periosteal estimation0.71.41.8-1.31.11.1-1.0
Bone: periosteal perimeter0.20.40.60.4-0.6-0.60.8
Bone: post-yield work0.50.70.8-0.90.90.9-0.9
Progressive ratio test 1 active lever presses0.10.10.20.5-0.2-0.20.0
Progressive ratio test 1 breakpoint0.10.10.10.20.20.2-0.3
Progressive ratio test 1 inactive lever presses0.20.30.4-0.6-0.4-0.40.6
Progressive ratio test 2 active lever presses0.70.81.11.10.80.8-0.9
Progressive ratio test 2 breakpoint0.50.60.60.70.80.8-0.8
Progressive ratio test 2 inactive lever presses0.70.82.9-1.70.30.3-0.2
Incentive Sensitization - Responses0.50.50.70.90.70.7-0.5
Incentive Sensitization - Breakpoint0.30.30.80.90.50.5-0.3
Sum of active levers in priming session hrs 5-60.30.30.70.8-0.5-0.50.4
Progressive ratio0.30.40.50.5-0.6-0.60.7
Food seeking constrained by brief footshock1.92.33.9-2.01.31.3-1.4
Seeking ratio, punishment vs. effort1.82.23.1-1.81.41.4-1.4
Retroperitoneal fat weight2.78.810.93.3-2.9-2.92.8
Reaction time number correct0.00.00.10.00.20.20.1
Reaction time mean minus median0.40.51.7-1.3-0.4-0.40.2
Reaction time mean minus median AUC0.60.72.2-1.5-0.5-0.50.4
Reaction time num false alarms0.30.31.11.1-0.3-0.30.1
Reaction time num false alarms AUC0.50.62.51.6-0.2-0.2-0.1
Reaction time trials correct on left0.00.00.10.00.20.20.1
Reaction time trials on left0.00.00.1-0.00.20.20.0
Reaction time mean1.72.33.10.4-1.8-1.81.8
Reaction time mean AUC1.41.82.50.0-1.5-1.51.6
Median of all reaction times2.23.04.10.7-1.9-2.02.0
Reaction time omissions0.00.00.1-0.20.10.1-0.3
Reaction time false alarm rate0.20.30.91.0-0.3-0.3-0.0
Reaction time premature initiation rate0.81.04.12.0-0.1-0.1-0.2
Reaction time premature initiations0.71.04.22.0-0.1-0.1-0.0
Std. dev. reaction times0.91.31.80.4-1.3-1.31.2
Reaction time trials completed0.00.00.1-0.00.20.20.0
Reaction time trials AUC0.00.00.00.20.10.10.2
Run reversals in cocaine runway, females0.10.10.2-0.1-0.2-0.20.5
Run reversals in cocaine runway, males2.82.73.61.2-1.7-1.71.9
Latency to leave start box in cocaine runway0.40.40.80.40.70.7-0.9
Latency to leave start box in cocaine runway, F0.20.20.50.40.40.4-0.7
Latency to leave start box in cocaine runway, M0.40.40.6-0.80.60.6-0.5
Std. dev. time between licks in bursts1.11.42.0-1.41.01.0-1.2
Total sessions with >9 infusions0.30.40.5-0.4-0.7-0.70.6
Short access day 1 total inactive lever presses0.30.30.40.6-0.4-0.40.7
Short access day 10 total inactive lever presses0.30.30.5-0.6-0.3-0.30.7
Short access day 1 total infusions0.90.93.6-1.90.30.3-0.1
Short access day 10 total infusions0.20.20.9-0.90.10.1-0.0
Short access total infusions0.80.92.3-1.50.70.7-0.7
Short access day 1 locomotion5.45.818.9-4.41.21.2-1.0
Short access day 10 total locomotion1.61.87.2-2.7-0.0-0.00.2
Short access total locomotion2.82.911.5-3.40.10.10.1
One hour access (0.3 mA shock)0.20.20.80.90.20.2-0.2
Compulsive drug intake1.91.94.9-2.21.01.0-0.8
One hour access (shock baseline)0.40.40.50.6-0.7-0.70.7
Social response proportion2.83.07.72.8-1.3-1.31.0
Social responses0.10.20.50.7-0.2-0.20.3
Social time0.00.00.1-0.40.10.1-0.0
Soleus weight1.23.63.8-1.91.91.9-1.9
Bone: stiffness0.60.91.0-1.00.90.9-0.9
Tibialis anterior weight0.20.81.1-0.61.01.0-1.0
Time to tail flick, vehicle, before self-admin0.40.40.60.10.80.8-0.8
Time to tail flick, vehicle, after self-admin10.911.713.23.0-3.6-3.63.4
Time to tail flick, test, before self-admin0.40.41.31.1-0.4-0.40.3
Time to tail flick, test, after self-admin0.91.01.30.2-1.2-1.21.1
Delta time to tail flick, vehicle, before/after SA10.410.312.62.2-3.6-3.63.3
Delta time to tail flick, test, before/after SA0.40.30.4-0.4-0.6-0.60.5
Tibia length0.20.60.80.9-0.7-0.70.7
Ambulatory time before self-admin0.10.10.2-0.5-0.1-0.10.2
Ambulatory time after self-admin2.52.83.0-1.51.71.7-1.7
Bone: tissue strength1.71.71.7-1.31.31.3-1.3
Total heroin consumption0.30.41.11.0-0.3-0.30.4
Bone: trabecular number0.00.00.0-0.1-0.1-0.10.1
Bone: trabecular spacing0.40.50.5-0.70.70.7-0.7
Bone: trabecular thickness0.10.10.20.0-0.3-0.30.4
Bone: trabecular tissue density0.30.50.5-0.70.70.7-0.7
Water consumed over 24 hours0.81.02.41.50.70.7-0.9
Number of responses in last shaping day2.72.85.3-2.3-1.3-1.31.7