Hub : Genes

Rnf126

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative polyA NM_001033702.1 0.07 0.05 3.3e-03 0 0 -0 0 2.2e-01 3.5e-01 7.6e-01 2.5e-01
2 Liver isoform ratio NM_001033702.1 0.06 0.05 4.9e-05 0.03 0.03 0.03 0.03 1.3e-04 4.9e-04 3.4e-04 3.3e-04
3 Liver isoform ratio XM_006240899.3 0.04 0.04 3.1e-03 0.02 0.01 0.01 0.01 3.3e-03 3.5e-02 5.1e-02 1.1e-02
4 Liver intron excision ratio chr7_9944012_9944114 0.06 0.05 2.0e-04 0.02 0.02 0.02 0.02 4.3e-03 3.7e-03 1.2e-03 1.3e-03
5 Liver intron excision ratio chr7_9943967_9944114 0.05 0.04 6.2e-04 0.01 0.01 0.01 0.02 1.0e-02 1.3e-02 8.4e-03 5.7e-03
6 Liver alternative polyA XM_017594811.2 0.1 0.07 1.4e-04 0.01 0.01 0 0.01 3.6e-02 1.6e-02 7.6e-02 1.6e-02
7 Brain gene expression Rnf126 0.07 0.06 3.9e-03 0.02 0.02 0.02 0.02 2.8e-03 4.6e-03 2.9e-03 3.8e-03
8 PL alternative polyA NM_001033702.1 0.11 0.08 1.3e-04 0.04 0.03 0.03 0.03 7.1e-05 1.9e-04 1.3e-04 2.6e-04
9 PL alternative polyA XM_017594811.2 0.11 0.08 1.2e-04 0.04 0.03 0.04 0.03 5.7e-05 1.6e-04 8.6e-05 1.9e-04
10 pVTA mRNA stability Rnf126 0.06 0.05 9.9e-03 0.03 0.03 0.02 0.03 1.8e-02 1.3e-02 6.4e-02 2.9e-02
11 OFC mRNA stability Rnf126 0.15 0.11 6.6e-04 0.11 0.12 0.12 0.11 1.7e-03 7.2e-04 8.7e-04 1.6e-03
12 Brain mRNA stability Rnf126 0.07 0.04 2.1e-07 0.06 0.07 0.06 0.06 2.1e-06 5.7e-07 3.0e-06 2.1e-06
13 PL intron excision ratio chr7_9945001_9945251 0.02 0.01 9.9e-03 0.02 0.02 0.01 0.01 4.7e-03 6.4e-03 1.7e-02 1.2e-02
14 PL mRNA stability Rnf126 0.02 0.02 2.6e-03 0.03 0.02 0.02 0.02 7.3e-04 3.1e-03 5.0e-03 1.6e-03
15 RMTg gene expression Rnf126 0.44 0.2 1.3e-03 0.1 0.08 0.07 0.11 1.0e-03 3.9e-03 4.6e-03 9.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.61.15.30.90.9-0.90.90.91.70.80.8-0.80.10.40.5-1.0-0.92.3
Area under the delay curve2.32.42.8-1.7-1.71.7-1.7-1.7-1.3-1.6-1.61.61.71.71.7-1.6-1.6-0.2
BMI with tail6.320.424.0-4.7-4.74.7-4.8-4.8-3.9-4.7-4.74.74.94.84.8-4.5-4.4-1.1
BMI without tail3.16.48.5-2.7-2.72.7-2.8-2.8-2.7-2.9-2.92.92.42.22.1-1.8-2.0-1.9
Body weight1.24.95.9-2.3-2.32.3-2.3-2.4-1.9-2.4-2.42.42.42.32.3-2.1-2.2-0.7
Weight adjusted by age1.21.42.7-1.3-1.31.3-1.3-1.3-1.6-1.3-1.31.30.90.70.6-0.5-0.5-1.6
Bone surface1.83.211.51.91.9-1.91.91.92.91.81.8-1.8-0.7-0.3-0.0-0.5-0.43.4
Bone volume1.62.810.61.71.7-1.71.71.72.71.61.6-1.6-0.5-0.10.1-0.6-0.63.3
Breakpoint value in progressive ratio session4.34.77.02.12.1-2.12.12.11.32.12.1-2.1-2.5-2.6-2.62.52.7-0.4
Number of licking bursts0.50.61.8-0.8-0.80.8-0.9-0.8-1.2-0.7-0.70.70.40.20.10.10.2-1.3
Context. condit. distance diff. score0.20.20.5-0.3-0.30.3-0.4-0.5-0.5-0.7-0.70.70.30.20.2-0.0-0.4-0.6
Locomotion velocity, session 11.11.22.31.21.2-1.21.11.21.51.31.3-1.3-0.8-0.7-0.60.30.51.5
Locomotion distance, session 12.12.77.81.91.9-1.91.81.82.71.41.4-1.4-1.0-0.7-0.50.3-0.22.8
Locomotion velocity, session 27.38.512.83.43.4-3.43.33.23.63.03.0-3.0-2.7-2.5-2.32.11.82.6
Locomotion distance, session 23.95.410.72.52.5-2.52.52.63.32.62.6-2.6-1.7-1.4-1.20.80.83.2
Locomotion velocity, session 36.07.09.92.72.7-2.72.62.71.92.52.5-2.5-3.0-3.0-3.13.12.9-0.1
Locomotion distance, session 30.00.00.20.10.1-0.1-0.0-0.0-0.2-0.2-0.20.2-0.1-0.1-0.20.30.1-0.5
Stereotopy head waving bouts, day 36.57.79.03.03.0-3.03.03.02.72.92.9-2.9-2.9-2.9-2.82.72.41.3
Stereotopy head waving duration, day 36.78.09.32.92.9-2.92.93.02.53.03.0-3.0-3.1-3.0-3.02.92.80.9
Locomotion velocity, session 70.70.71.81.01.0-1.00.90.80.50.30.3-0.3-1.0-1.1-1.11.40.7-0.4
Locomotion distance, session 70.50.62.2-0.7-0.70.7-0.8-0.8-1.1-1.0-1.01.00.50.30.30.0-0.2-1.5
Stereotopy head waving bouts, day 70.50.61.60.90.9-0.90.80.81.20.70.7-0.7-0.4-0.3-0.20.1-0.11.2
Stereotopy head waving duration, day 70.81.02.21.21.2-1.21.11.11.51.01.0-1.0-0.7-0.6-0.50.30.21.5
Locomotion velocity, session 82.42.96.02.02.0-2.01.81.92.51.61.6-1.6-1.3-1.1-1.01.00.42.3
Locomotion distance, session 80.71.02.01.31.3-1.31.11.11.40.90.9-0.9-0.9-0.7-0.70.60.31.1
Degree of sensitization distance0.30.30.5-0.5-0.50.5-0.6-0.6-0.4-0.7-0.70.70.60.60.6-0.5-0.7-0.1
Degree of sensitization stereotypy1.11.32.6-0.9-0.90.9-0.9-0.9-0.3-1.0-1.01.01.41.41.5-1.6-1.60.6
Conditioned locomotion2.32.63.8-1.7-1.71.7-1.7-1.8-2.0-1.9-1.91.91.51.31.2-1.0-1.0-1.6
Cocaine response after cond. corrected8.39.312.4-3.4-3.43.4-3.4-3.4-3.5-3.3-3.33.32.92.72.5-2.3-2.0-2.4
Cocaine response after cond. not corrected8.69.512.8-3.4-3.43.4-3.4-3.4-3.6-3.4-3.43.42.92.72.5-2.2-2.1-2.5
Cocaine response before conditioning0.70.81.21.11.1-1.11.11.00.90.80.8-0.8-1.0-0.9-0.91.00.60.3
Saline control response0.10.10.1-0.3-0.30.3-0.3-0.3-0.3-0.3-0.30.30.30.30.2-0.2-0.1-0.2
Bone: connectivity density0.40.63.00.40.4-0.40.40.31.00.20.2-0.20.40.60.8-1.1-1.11.7
Bone: cortical apparent density1.21.52.2-1.5-1.51.5-1.4-1.3-1.1-1.0-1.01.01.31.31.3-1.4-1.0-0.1
Bone: cortical area0.30.51.4-0.4-0.40.4-0.4-0.50.1-0.6-0.60.60.80.91.0-1.0-1.20.8
Bone: cortical porosity0.80.91.51.11.1-1.11.11.11.21.01.0-1.0-0.8-0.7-0.60.50.51.0
Bone: cortical porosity0.60.62.10.90.9-0.90.90.81.30.70.7-0.7-0.3-0.1-0.1-0.1-0.21.5
Bone: cortical thickness0.81.42.5-1.0-1.01.0-1.0-1.1-0.5-1.1-1.11.11.41.51.5-1.5-1.60.5
Bone: cortical thickness0.40.51.8-0.8-0.80.8-0.7-0.7-1.1-0.7-0.70.70.30.20.10.10.2-1.3
Bone: cortical tissue density0.91.11.8-1.3-1.31.3-1.3-1.2-1.0-0.8-0.80.81.11.11.1-1.2-0.8-0.1
Condit. Reinf. active minus inactive responses4.75.36.42.42.4-2.42.42.41.92.32.3-2.3-2.5-2.5-2.52.52.50.4
Condit. Reinf. active-inactive response ratio1.41.53.91.01.0-1.01.01.10.41.21.2-1.2-1.4-1.5-1.61.52.0-0.7
Condit. Reinf. active responses5.56.88.42.92.9-2.92.92.92.82.72.7-2.7-2.6-2.4-2.32.22.11.6
Condit. Reinf. inactive responses2.63.15.82.02.0-2.02.02.02.41.81.8-1.8-1.3-1.1-1.00.80.62.1
Incentive salience index mean3.74.55.82.42.4-2.42.42.32.32.12.1-2.1-2.1-2.0-1.91.81.71.3
Condit. Reinf. lever presses1.21.76.51.41.4-1.41.41.32.21.11.1-1.1-0.5-0.2-0.1-0.2-0.32.5
Condit. Reinf. active minus inactive responses1.01.33.10.80.8-0.80.80.90.11.01.0-1.0-1.3-1.4-1.51.61.8-1.0
Condit. Reinf. active-inactive response ratio0.40.41.6-0.8-0.80.8-0.7-0.6-1.1-0.3-0.30.30.30.20.1-0.10.5-1.3
Condit. Reinf. active responses1.11.52.81.01.0-1.01.11.10.41.21.2-1.2-1.4-1.5-1.61.71.7-0.6
Condit. Reinf. inactive responses0.91.12.21.01.0-1.01.01.00.60.90.9-0.9-1.3-1.3-1.31.51.1-0.1
Condit. Reinf. lever presses1.31.83.61.21.2-1.21.21.20.41.21.2-1.2-1.6-1.7-1.71.71.9-0.9
Condit. Reinf. lever reinforcers received0.70.92.20.60.6-0.60.70.7-0.00.80.8-0.8-1.1-1.3-1.41.51.5-1.0
Conditioned reinforcement - actives1.91.92.61.61.6-1.61.61.51.21.41.4-1.4-1.4-1.4-1.41.41.40.1
Conditioned reinforcement - inactives0.60.71.1-0.8-0.80.8-0.8-0.9-1.0-1.1-1.11.10.70.70.6-0.5-0.5-0.9
Conditioned locomotion6.47.69.03.03.0-3.03.02.92.22.82.8-2.8-3.0-3.0-2.92.82.90.2
Patch foraging indifference point 0 sec0.10.10.3-0.3-0.30.3-0.3-0.3-0.0-0.2-0.20.20.50.60.6-0.6-0.60.4
Patch foraging indifference point AUC0.50.61.10.70.7-0.70.80.80.50.80.8-0.8-0.9-0.9-0.90.81.1-0.0
Delay disc. indifference point, 0s delay4.34.810.2-1.7-1.71.7-1.7-1.7-0.3-1.7-1.71.72.62.83.0-3.2-3.21.9
Delay disc. indifference point, 16s delay0.20.20.3-0.5-0.50.5-0.5-0.5-0.4-0.3-0.30.30.40.40.4-0.4-0.3-0.1
Delay disc. indifference point, 2s delay4.24.77.4-2.1-2.12.1-2.1-2.1-1.2-2.1-2.12.12.52.62.6-2.6-2.70.6
Delay disc. indifference point, 24s delay1.31.21.6-1.3-1.31.3-1.3-1.2-1.2-1.1-1.11.11.11.11.0-1.0-0.8-0.5
Delay disc. indifference point, 4s delay0.70.71.1-0.8-0.80.8-0.8-0.8-0.5-0.8-0.80.80.91.01.0-1.0-1.00.2
Delay disc. indifference point, 8s delay2.02.02.6-1.6-1.61.6-1.6-1.6-1.6-1.6-1.61.61.31.21.2-1.0-1.1-1.0
Indifference point function ln k0.40.50.7-0.8-0.80.8-0.8-0.8-0.8-0.8-0.80.80.60.60.6-0.5-0.6-0.6
Indifference point function log k0.40.50.7-0.8-0.80.8-0.8-0.8-0.8-0.8-0.80.80.60.60.6-0.5-0.6-0.6
Patch foraging total patch changes 0 sec0.10.10.2-0.3-0.30.3-0.3-0.3-0.1-0.3-0.30.30.40.40.5-0.4-0.40.2
Patch foraging total patch changes 12 sec0.50.60.8-0.8-0.80.8-0.8-0.9-0.9-0.9-0.90.90.80.70.7-0.5-0.4-0.7
Patch foraging total patch changes 18 sec1.01.31.81.11.1-1.11.21.20.91.21.2-1.2-1.2-1.2-1.21.21.30.2
Patch foraging total patch changes 24 sec0.10.10.20.20.2-0.20.20.30.30.40.4-0.4-0.2-0.1-0.10.00.20.3
Patch foraging total patch changes 6 sec0.20.30.50.40.4-0.40.50.50.50.70.7-0.7-0.4-0.4-0.40.30.60.5
Patch foraging time to switch 0 sec0.50.84.10.10.1-0.10.0-0.01.0-0.2-0.20.20.81.01.2-1.3-1.62.0
Patch foraging water rate 0 sec0.81.35.5-1.1-1.11.1-1.1-1.1-1.9-1.1-1.11.10.30.1-0.10.50.4-2.3
Patch foraging water rate 12 sec2.84.27.5-2.4-2.42.4-2.4-2.3-2.7-2.2-2.22.21.61.41.2-1.0-0.9-2.3
Patch foraging water rate 18 sec1.72.211.0-1.4-1.41.4-1.4-1.4-2.5-1.3-1.31.30.3-0.0-0.30.70.8-3.3
Patch foraging water rate 24 sec2.63.610.3-2.1-2.12.1-2.0-2.0-2.9-2.0-2.02.01.10.70.5-0.1-0.1-3.2
Patch foraging water rate 6 sec0.60.84.9-0.7-0.70.7-0.7-0.7-1.5-0.6-0.60.6-0.2-0.4-0.60.70.8-2.2
Seeking ratio, delayed vs. immediate footshock4.14.75.82.22.2-2.22.32.31.92.42.4-2.4-2.3-2.3-2.22.22.00.8
Distance traveled before self-admin0.40.50.9-0.7-0.70.7-0.6-0.6-0.2-0.5-0.50.50.80.80.9-1.0-0.90.6
Distance traveled after self-admin0.60.60.80.80.8-0.80.80.90.80.90.9-0.9-0.8-0.8-0.70.60.60.6
Extensor digitorum longus weight4.818.724.0-4.5-4.54.5-4.6-4.7-4.2-4.9-4.94.94.44.24.1-3.6-4.0-2.1
Bone: elastic displacement0.10.10.30.20.2-0.20.30.30.30.60.6-0.6-0.2-0.2-0.20.00.40.3
Bone: elastic work0.30.40.8-0.7-0.70.7-0.7-0.6-0.4-0.4-0.40.40.80.80.8-0.9-0.60.2
Bone: endosteal estimation0.10.20.3-0.4-0.40.4-0.5-0.4-0.2-0.4-0.40.40.50.50.5-0.4-0.50.2
Bone: endosteal perimeter0.40.81.21.11.1-1.11.01.01.10.90.9-0.9-0.9-0.8-0.80.70.50.7
Epididymis fat weight0.20.50.90.70.7-0.70.70.70.30.70.7-0.7-0.8-0.8-0.90.90.9-0.3
Delta time in closed arm before/after self-admin2.92.86.0-1.9-1.91.9-1.9-1.9-2.4-1.8-1.81.81.20.90.8-0.4-0.4-2.4
Delta time in open arm before/after self-admin0.90.81.7-0.8-0.80.8-0.8-0.8-0.4-0.8-0.80.81.11.21.2-1.3-1.20.4
Diff in mean of infusions in LGA sessions1.92.12.51.51.5-1.51.51.51.11.51.5-1.5-1.6-1.6-1.61.41.60.2
Delay discount exponential model param2.22.42.71.61.6-1.61.61.61.31.61.6-1.6-1.6-1.6-1.61.51.60.3
Extinction: sum of active levers before priming0.80.81.50.80.8-0.80.80.80.20.60.6-0.6-1.0-1.1-1.21.21.2-0.7
Active lever presses in extinction session 62.32.22.71.51.5-1.51.61.61.31.61.6-1.6-1.6-1.5-1.51.21.50.6
Bone: final force0.91.42.9-1.1-1.11.1-1.1-1.1-0.5-1.2-1.21.21.41.41.5-1.4-1.70.5
Bone: final moment0.71.22.2-1.0-1.01.0-1.0-1.0-0.5-1.0-1.01.01.31.31.3-1.3-1.50.5
Food consumed during 24 hour testing period1.01.22.0-1.4-1.41.4-1.3-1.3-1.3-1.0-1.01.01.00.90.9-0.8-0.8-0.5
Glucose1.72.53.2-1.8-1.81.8-1.8-1.7-1.4-1.5-1.51.51.71.71.6-1.6-1.6-0.4
Heart weight0.10.20.8-0.0-0.00.00.00.1-0.40.20.2-0.2-0.3-0.4-0.50.40.8-0.9
Delay discount hyperbolic model param2.93.13.61.81.8-1.81.81.91.41.81.8-1.8-1.9-1.9-1.91.81.90.2
Intermittent access intake day 1-15 change5.55.47.62.42.4-2.42.42.31.62.22.2-2.2-2.6-2.7-2.72.82.6-0.2
Intermittent access intake escalation4.34.27.81.91.9-1.91.91.90.91.71.7-1.7-2.4-2.6-2.62.82.7-1.1
Intermittent access intake escalation 25.25.18.72.22.2-2.22.12.11.12.02.0-2.0-2.6-2.8-2.82.92.9-1.0
Intermitt. access day 1 inactive lever presses0.20.21.2-0.2-0.20.2-0.1-0.2-0.6-0.3-0.30.3-0.2-0.3-0.30.40.5-1.1
Intermitt. access day 15 inactive lever presses0.40.40.80.60.6-0.60.60.50.20.50.5-0.5-0.8-0.8-0.80.90.8-0.4
Intermitt. access escalation Index0.20.21.2-0.0-0.00.0-0.00.00.50.10.1-0.10.30.40.5-0.6-0.61.1
Intermittent access day 1 total infusions0.00.00.1-0.1-0.10.1-0.1-0.1-0.1-0.2-0.20.20.20.30.3-0.4-0.20.0
Intermittent access day 15 total infusions1.41.52.61.21.2-1.21.21.20.61.01.0-1.0-1.4-1.5-1.51.61.6-0.7
Intermittent access terminal intake (last 3 days)0.80.91.21.11.1-1.11.11.00.60.80.8-0.8-1.1-1.1-1.11.11.1-0.3
Intermittent access total infusions0.10.10.30.40.4-0.40.40.30.10.20.2-0.2-0.4-0.5-0.50.50.5-0.4
Intermittent access day 1 locomotion0.30.30.60.60.6-0.60.60.60.30.50.5-0.5-0.7-0.7-0.70.70.8-0.3
Intermittent access day 15 total locomotion3.23.54.31.91.9-1.91.91.91.31.81.8-1.8-2.1-2.1-2.12.12.1-0.1
Intermittent access total locomotion0.91.11.31.11.1-1.11.21.10.91.01.0-1.0-1.1-1.1-1.01.01.00.1
Intermittent access standard deviation1.81.93.31.31.3-1.31.31.30.61.21.2-1.2-1.6-1.7-1.71.81.8-0.7
Left kidney weight0.10.20.80.30.3-0.30.40.40.60.50.5-0.5-0.3-0.2-0.20.1-0.00.9
Right kidney weight1.23.24.11.81.8-1.81.81.81.41.91.9-1.9-2.0-2.0-2.01.91.90.4
Cocaine induced anxiety1.21.42.71.31.3-1.31.31.31.61.31.3-1.3-0.9-0.7-0.60.40.41.6
Post-drug Anxiety1.21.32.51.31.3-1.31.21.31.61.31.3-1.3-0.9-0.7-0.60.50.51.5
Baseline Anxiety0.20.21.1-0.0-0.00.0-0.0-0.0-0.5-0.0-0.00.0-0.3-0.5-0.50.60.6-1.0
Tail length2.57.611.22.82.8-2.82.72.71.82.52.5-2.5-3.2-3.3-3.33.43.1-0.4
Length with tail1.86.67.72.72.7-2.72.82.72.32.62.6-2.6-2.8-2.7-2.72.62.40.8
Length without tail0.30.72.10.90.9-0.91.00.91.30.90.9-0.9-0.5-0.3-0.20.20.11.5
Times rat made contact with spout0.70.81.7-1.1-1.11.1-1.1-1.0-1.3-0.9-0.90.90.60.50.4-0.2-0.3-1.1
Lifetime Intake0.10.10.10.30.3-0.30.30.30.10.10.1-0.1-0.3-0.3-0.30.30.3-0.2
Liver weight, left2.13.34.1-1.9-1.91.9-1.9-1.9-1.6-2.0-2.02.01.91.91.9-1.7-1.8-0.6
Liver weight, right1.01.72.8-1.2-1.21.2-1.2-1.3-0.7-1.4-1.41.41.41.51.5-1.4-1.70.3
Locomotor activity3.65.87.22.62.6-2.62.72.72.72.62.6-2.6-2.4-2.2-2.11.91.61.7
Locomotor testing distance1.93.23.92.02.0-2.02.02.01.92.02.0-2.0-1.8-1.7-1.61.41.41.1
Locomotor testing rearing0.10.10.8-0.3-0.30.3-0.3-0.3-0.6-0.3-0.30.30.0-0.1-0.10.20.2-0.9
Locomotion in novel chamber0.10.10.2-0.1-0.10.1-0.1-0.0-0.30.20.2-0.2-0.2-0.3-0.40.50.4-0.4
Locomotion in novel chamber post-restriction0.70.81.70.80.8-0.80.80.70.30.60.6-0.6-1.1-1.2-1.21.31.2-0.7
Fecal boli incidents, locomotor time 11.81.92.5-1.4-1.41.4-1.4-1.5-1.2-1.6-1.61.61.41.41.4-1.2-1.4-0.5
Change in fecal boli incidents, locomotor task0.10.10.20.40.4-0.40.40.40.50.40.4-0.4-0.3-0.3-0.30.40.20.4
Time >=10cm from walls, locomotor time 10.60.61.4-0.5-0.50.5-0.5-0.40.2-0.4-0.40.40.81.01.0-1.2-1.21.2
Bouts of movement, locomotor time 10.20.20.90.30.3-0.30.30.30.10.20.2-0.2-0.6-0.6-0.60.90.4-0.3
Total resting periods, locomotor time 10.30.30.90.50.5-0.50.50.50.30.40.4-0.4-0.7-0.7-0.70.90.5-0.2
Rest time, locomotor task time 10.70.81.31.01.0-1.00.90.90.90.70.7-0.7-1.0-1.0-0.91.20.50.4
Distance moved, locomotor task time 10.60.62.1-0.6-0.60.6-0.5-0.50.1-0.3-0.30.31.01.11.1-1.5-1.11.0
Vertical activity count, locomotor time 11.01.01.7-1.2-1.21.2-1.2-1.1-1.3-0.9-0.90.90.90.90.8-1.0-0.3-1.0
Time >=10cm from walls, locomotor time 22.22.32.8-1.6-1.61.6-1.7-1.7-1.5-1.7-1.71.71.51.41.4-1.2-1.4-0.7
Bouts of movement, locomotor time 21.21.32.31.21.2-1.21.21.31.51.31.3-1.3-0.9-0.8-0.70.50.51.4
Total resting periods, locomotor time 21.21.22.31.21.2-1.21.21.21.51.31.3-1.3-0.9-0.7-0.60.40.51.5
Rest time, locomotor task time 20.81.01.31.01.0-1.01.01.11.11.11.1-1.1-1.0-0.9-0.80.80.60.9
Distance moved, locomotor task time 20.81.01.2-1.0-1.01.0-1.0-1.0-1.0-1.1-1.11.11.01.00.9-0.8-0.8-0.6
Vertical activity count, locomotor time 21.41.52.3-1.3-1.31.3-1.3-1.3-1.5-1.5-1.51.51.00.90.8-0.8-0.7-1.4
Light reinforcement 16.611.914.13.73.7-3.73.73.83.33.73.7-3.7-3.6-3.5-3.43.03.11.4
Light reinforcement 22.53.34.22.12.1-2.12.02.11.82.02.0-2.0-1.7-1.6-1.61.41.50.8
Bone: marrow area0.10.20.3-0.4-0.40.4-0.5-0.4-0.2-0.4-0.40.40.50.40.5-0.4-0.60.2
Bone: maximum diameter1.12.03.01.61.6-1.61.61.61.71.51.5-1.5-1.3-1.2-1.11.00.81.3
Bone: maximum force1.01.72.6-1.3-1.31.3-1.3-1.3-0.8-1.3-1.31.31.51.51.5-1.3-1.60.2
Bone: maximum moment0.81.42.0-1.2-1.21.2-1.2-1.2-0.8-1.2-1.21.21.31.31.4-1.3-1.40.2
Mean time between licks in bursts3.44.76.32.22.2-2.22.22.21.42.22.2-2.2-2.4-2.5-2.52.52.4-0.2
Mean num. licks in bursts0.00.00.1-0.1-0.10.1-0.0-0.00.10.00.0-0.00.10.10.2-0.2-0.30.3
Cd content in liver0.20.30.5-0.5-0.50.5-0.4-0.5-0.2-0.4-0.40.40.60.60.7-0.7-0.70.2
Co content in liver0.50.60.90.90.9-0.90.80.80.60.60.6-0.6-0.9-0.9-0.90.90.8-0.2
Cu content in liver0.20.21.50.30.3-0.30.30.20.70.10.1-0.10.10.20.3-0.4-0.71.2
Fe content in liver0.20.20.60.60.6-0.60.50.40.2-0.1-0.10.1-0.4-0.5-0.50.80.3-0.5
K content in liver0.80.72.21.11.1-1.11.00.91.50.50.5-0.5-0.4-0.3-0.10.3-0.41.5
Mg content in liver0.60.62.30.90.9-0.90.80.71.30.50.5-0.5-0.2-0.10.00.1-0.51.5
Mn content in liver3.33.77.62.32.3-2.32.32.22.81.81.8-1.8-1.5-1.3-1.11.00.42.4
Na content in liver0.50.51.80.40.4-0.40.30.10.9-0.4-0.40.40.50.60.8-0.7-1.41.3
Rb content in liver0.30.31.90.10.1-0.10.10.10.7-0.0-0.00.00.40.60.7-0.8-1.01.4
Se content in liver0.60.71.11.11.1-1.11.00.90.90.60.6-0.6-0.9-0.9-0.81.00.40.4
Sr content in liver0.20.21.4-0.4-0.40.4-0.4-0.4-0.8-0.4-0.40.40.1-0.1-0.10.20.3-1.2
Zn content in liver0.91.03.10.30.3-0.30.40.4-0.60.50.5-0.5-1.1-1.2-1.41.51.7-1.8
Bone: minimum diameter0.00.10.30.40.4-0.40.30.30.50.10.1-0.1-0.2-0.1-0.10.2-0.20.5
Time in familiar zone, hab. session 11.51.42.81.01.0-1.01.01.00.31.01.0-1.0-1.4-1.5-1.51.51.7-0.9
Time in novel zone, hab. session 10.70.71.7-0.6-0.60.6-0.5-0.60.1-0.5-0.50.51.01.11.1-1.2-1.31.2
Total zone transitions, hab. session 12.23.15.72.02.0-2.02.02.02.41.81.8-1.8-1.5-1.3-1.11.00.92.1
Total locomotion distance, hab. session 13.44.89.52.62.6-2.62.52.43.12.12.1-2.1-1.8-1.5-1.31.20.82.8
Locomotion velocity, hab. session 14.05.710.12.82.8-2.82.82.73.22.42.4-2.4-2.0-1.8-1.61.51.12.7
Time in familiar zone, hab. session 24.24.48.51.71.7-1.71.81.90.82.12.1-2.1-2.5-2.6-2.72.62.9-1.0
Time in novel zone, hab. session 23.73.75.8-1.9-1.91.9-2.0-1.8-0.9-1.8-1.81.82.22.32.3-2.3-2.40.9
Total zone transitions, hab. session 21.11.49.20.80.8-0.80.70.92.01.01.0-1.0-0.10.20.4-0.6-0.83.0
Total locomotion distance, hab. session 22.53.25.91.91.9-1.91.81.92.42.02.0-2.0-1.5-1.3-1.20.90.92.4
Locomotion velocity, hab. session 22.93.98.92.02.0-2.02.02.12.82.22.2-2.2-1.6-1.3-1.10.80.73.0
Novel to familiar place preference ratio2.93.06.0-1.4-1.41.4-1.4-1.4-0.4-1.5-1.51.52.02.22.3-2.4-2.51.4
Novelty place preference1.71.73.7-1.0-1.01.0-1.0-1.0-0.1-1.0-1.01.01.51.71.8-1.9-1.91.3
Time in novel zone, NPP test2.02.04.0-1.2-1.21.2-1.2-1.2-0.3-1.2-1.21.21.71.81.9-1.9-2.01.1
Total zone transitions, NPP test0.71.05.20.90.9-0.90.91.01.71.01.0-1.0-0.3-0.10.1-0.3-0.32.3
Total locomotion distance, NPP test0.81.04.91.11.1-1.11.01.01.70.90.9-0.9-0.4-0.10.0-0.2-0.32.2
Locomotion velocity, NPP test1.01.45.21.21.2-1.21.21.21.91.21.2-1.2-0.6-0.4-0.20.0-0.12.3
Intraocular pressure0.71.04.0-1.1-1.11.1-1.0-1.0-1.7-0.7-0.70.70.40.20.1-0.00.5-2.0
Delta distance traveled before/after self-admin1.92.02.51.61.6-1.61.51.51.21.41.4-1.4-1.5-1.5-1.51.51.40.2
Delta ambulatory time before/after self-admin2.22.43.01.71.7-1.71.71.71.41.51.5-1.5-1.7-1.6-1.61.61.40.4
Parametrial fat weight0.20.41.00.50.5-0.50.50.50.10.50.5-0.5-0.8-0.9-0.90.91.0-0.6
Pavlov. Cond. lever latency0.60.82.1-1.1-1.11.1-1.0-0.9-1.5-0.5-0.50.50.50.40.2-0.30.2-1.4
Pavlov. Cond. magazine entry latency3.84.86.42.42.4-2.42.32.31.82.02.0-2.0-2.5-2.5-2.52.52.30.1
Pavlov. Cond. change in total contacts0.50.50.80.90.9-0.90.80.70.80.40.4-0.4-0.7-0.7-0.60.80.40.4
Pavlov. Cond. index score1.51.93.01.71.7-1.71.71.51.71.11.1-1.1-1.4-1.3-1.21.30.81.0
Pavlov. Cond. latency score1.82.34.11.91.9-1.91.91.72.01.21.2-1.2-1.4-1.3-1.11.20.61.5
Pavlov. Cond. lever contacts1.01.23.11.41.4-1.41.31.21.70.80.8-0.8-0.7-0.6-0.40.5-0.11.7
Pavlov. Cond. magazine entry number1.41.72.3-1.5-1.51.5-1.5-1.4-1.2-1.1-1.11.11.41.41.4-1.4-1.2-0.3
Pavlov. Cond. intertrial magazine entries0.10.21.0-0.3-0.30.3-0.3-0.2-0.7-0.1-0.10.1-0.1-0.2-0.30.30.5-1.0
Pavlov. Cond. lever-magazine prob. diff.2.02.53.71.91.9-1.91.81.71.81.31.3-1.3-1.6-1.5-1.41.51.01.0
Pavlov. Cond. response bias1.92.43.21.81.8-1.81.81.61.51.31.3-1.3-1.7-1.7-1.61.71.30.4
Pavlov. Cond. lever latency0.30.40.7-0.6-0.60.6-0.7-0.6-0.3-0.6-0.60.60.70.80.8-0.8-0.90.3
Pavlov. Cond. magazine entry latency0.40.40.70.70.7-0.70.70.70.50.50.5-0.5-0.8-0.8-0.80.90.6-0.1
Pavlov. Cond. change in total contacts0.20.30.70.40.4-0.40.50.50.10.50.5-0.5-0.6-0.7-0.70.70.8-0.5
Pavlov. Cond. index score0.40.50.90.70.7-0.70.70.60.30.60.6-0.6-0.8-0.9-0.91.00.9-0.4
Pavlov. Cond. latency score0.40.50.70.70.7-0.70.70.70.40.70.7-0.7-0.8-0.8-0.80.80.8-0.2
Pavlov. Cond. lever contacts0.30.41.00.40.4-0.40.50.4-0.00.40.4-0.4-0.7-0.8-0.90.91.0-0.8
Pavlov. Cond. magazine entry number0.60.81.2-1.0-1.01.0-1.0-0.9-0.6-0.7-0.70.71.01.01.0-1.1-0.80.1
Pavlov. Cond. intertrial magazine entries0.60.81.3-1.0-1.01.0-1.0-1.0-1.2-1.0-1.01.00.70.60.5-0.4-0.3-1.0
Pavlov. Cond. lever-magazine prob. diff.0.50.61.00.80.8-0.80.80.80.50.70.7-0.7-0.9-0.9-0.91.00.9-0.2
Pavlov. Cond. response bias0.91.22.40.90.9-0.91.00.90.30.90.9-0.9-1.3-1.4-1.51.51.5-0.8
Time in closed arm before self-admin0.40.52.60.10.1-0.10.10.00.8-0.1-0.10.10.60.80.9-1.0-1.11.6
Time in closed arm after self-admin0.00.00.10.00.0-0.00.00.0-0.10.00.0-0.0-0.1-0.2-0.20.20.2-0.2
Time in open arm before self-admin0.40.51.10.60.6-0.60.60.60.20.60.6-0.6-0.8-0.9-0.91.00.9-0.4
Time in open arm after self-admin0.91.01.2-1.1-1.11.1-1.1-1.0-0.9-1.0-1.01.01.11.11.0-1.0-0.9-0.3
Bone: periosteal estimation0.10.30.9-0.3-0.30.3-0.3-0.30.2-0.3-0.30.30.60.70.7-0.7-1.00.9
Bone: periosteal perimeter0.20.41.00.80.8-0.80.70.71.00.60.6-0.6-0.4-0.3-0.20.2-0.01.0
Bone: post-yield work0.40.61.2-0.7-0.70.7-0.7-0.8-0.7-1.1-1.11.10.70.60.6-0.3-0.8-0.6
Progressive ratio test 1 active lever presses0.20.20.6-0.5-0.50.5-0.5-0.5-0.7-0.5-0.50.50.20.10.10.0-0.0-0.8
Progressive ratio test 1 breakpoint0.30.30.6-0.6-0.60.6-0.5-0.6-0.7-0.6-0.60.60.30.20.2-0.0-0.1-0.7
Progressive ratio test 1 inactive lever presses0.00.00.10.20.2-0.20.10.20.10.20.2-0.2-0.2-0.2-0.20.20.2-0.1
Progressive ratio test 2 active lever presses0.10.10.80.00.0-0.00.0-0.0-0.4-0.1-0.10.1-0.2-0.3-0.40.50.5-0.9
Progressive ratio test 2 breakpoint0.10.10.30.30.3-0.30.30.30.00.20.2-0.2-0.4-0.4-0.50.50.5-0.5
Progressive ratio test 2 inactive lever presses0.10.10.20.40.4-0.40.40.40.40.20.2-0.2-0.2-0.2-0.20.10.10.2
Incentive Sensitization - Responses0.10.10.7-0.0-0.00.0-0.0-0.1-0.4-0.2-0.20.2-0.1-0.2-0.20.30.4-0.8
Incentive Sensitization - Breakpoint0.10.10.50.10.1-0.10.10.1-0.3-0.1-0.10.1-0.2-0.3-0.30.40.5-0.7
Sum of active levers in priming session hrs 5-60.00.00.00.10.1-0.10.10.10.10.10.1-0.10.00.10.1-0.2-0.10.2
Progressive ratio0.10.10.2-0.2-0.20.2-0.3-0.3-0.3-0.4-0.40.40.20.20.2-0.1-0.1-0.2
Food seeking constrained by brief footshock0.70.91.31.11.1-1.11.11.01.20.90.9-0.9-1.0-0.9-0.80.80.50.8
Seeking ratio, punishment vs. effort0.40.50.80.80.8-0.80.80.80.90.80.8-0.8-0.7-0.6-0.50.40.20.7
Retroperitoneal fat weight0.20.70.9-1.0-1.01.0-0.9-1.0-0.9-1.0-1.01.00.80.80.7-0.7-0.6-0.5
Reaction time number correct1.62.44.8-1.7-1.71.7-1.7-1.7-2.2-1.7-1.71.71.00.80.7-0.4-0.4-2.1
Reaction time mean minus median0.30.50.90.60.6-0.60.60.60.20.50.5-0.5-0.8-0.9-0.91.01.0-0.5
Reaction time mean minus median AUC0.10.10.60.30.3-0.30.30.30.60.30.3-0.3-0.1-0.1-0.0-0.0-0.10.8
Reaction time num false alarms0.60.82.8-0.7-0.70.7-0.8-0.9-1.3-1.1-1.11.10.60.40.30.0-0.3-1.7
Reaction time num false alarms AUC0.81.13.6-0.9-0.90.9-1.0-1.0-1.5-1.3-1.31.30.60.50.40.0-0.3-1.9
Reaction time trials correct on left1.62.44.8-1.7-1.71.7-1.7-1.7-2.2-1.7-1.71.71.00.80.7-0.4-0.4-2.1
Reaction time trials on left1.62.34.5-1.7-1.71.7-1.7-1.7-2.1-1.6-1.61.61.10.80.7-0.4-0.4-2.0
Reaction time mean0.00.00.2-0.1-0.10.1-0.1-0.10.10.00.0-0.00.20.20.2-0.3-0.30.4
Reaction time mean AUC0.10.10.2-0.2-0.20.2-0.2-0.20.0-0.0-0.00.00.30.40.4-0.5-0.40.5
Median of all reaction times0.20.30.8-0.5-0.50.5-0.4-0.4-0.1-0.3-0.30.30.70.70.7-0.9-0.90.6
Reaction time omissions0.20.30.70.40.4-0.40.40.50.50.80.8-0.8-0.4-0.4-0.40.10.50.6
Reaction time false alarm rate0.00.10.20.00.0-0.0-0.0-0.1-0.2-0.4-0.40.40.20.20.2-0.0-0.3-0.4
Reaction time premature initiation rate0.50.72.00.50.5-0.50.60.60.00.80.8-0.8-0.9-1.0-1.11.11.4-0.7
Reaction time premature initiations0.40.63.4-0.4-0.40.4-0.3-0.2-1.10.00.0-0.0-0.5-0.7-0.81.01.3-1.8
Std. dev. reaction times0.10.10.20.20.2-0.20.30.30.10.30.3-0.3-0.3-0.4-0.40.40.4-0.1
Reaction time trials completed1.62.34.5-1.7-1.71.7-1.7-1.7-2.1-1.6-1.61.61.10.80.7-0.4-0.4-2.0
Reaction time trials AUC1.82.55.4-1.8-1.81.8-1.8-1.8-2.3-1.7-1.71.71.00.80.7-0.3-0.3-2.3
Run reversals in cocaine runway, females0.50.50.60.70.7-0.70.70.70.70.80.8-0.8-0.8-0.8-0.80.80.70.4
Run reversals in cocaine runway, males1.81.72.21.41.4-1.41.41.41.31.51.5-1.5-1.4-1.3-1.31.11.20.6
Latency to leave start box in cocaine runway1.11.22.31.21.2-1.21.21.31.51.41.4-1.4-0.7-0.5-0.40.10.21.5
Latency to leave start box in cocaine runway, F0.70.74.40.40.4-0.40.40.51.30.60.6-0.60.30.60.7-1.1-0.92.1
Latency to leave start box in cocaine runway, M1.81.73.81.11.1-1.11.11.10.31.01.0-1.0-1.6-1.7-1.82.01.8-1.0
Std. dev. time between licks in bursts0.70.91.01.01.0-1.01.01.00.91.01.0-1.0-0.9-0.9-0.90.90.70.5
Total sessions with >9 infusions0.00.00.20.10.1-0.10.00.00.2-0.0-0.00.00.10.20.2-0.2-0.30.4
Short access day 1 total inactive lever presses0.10.10.20.40.4-0.40.40.40.30.30.3-0.3-0.4-0.3-0.30.30.30.1
Short access day 10 total inactive lever presses0.00.00.1-0.2-0.20.2-0.2-0.2-0.3-0.2-0.20.20.10.00.0-0.0-0.0-0.3
Short access day 1 total infusions0.50.61.10.90.9-0.90.90.91.10.80.8-0.8-0.6-0.5-0.40.30.20.8
Short access day 10 total infusions0.10.10.6-0.0-0.00.0-0.1-0.1-0.4-0.2-0.20.2-0.2-0.2-0.30.40.4-0.7
Short access total infusions0.00.00.00.20.2-0.20.20.10.20.00.0-0.0-0.00.00.0-0.0-0.10.1
Short access day 1 locomotion1.21.31.71.31.3-1.31.31.31.21.21.2-1.2-1.2-1.1-1.00.90.90.6
Short access day 10 total locomotion2.83.24.71.81.8-1.81.81.81.11.71.7-1.7-2.0-2.1-2.12.22.1-0.4
Short access total locomotion0.80.81.11.01.0-1.01.11.00.80.90.9-0.9-1.0-0.9-0.90.90.80.2
One hour access (0.3 mA shock)0.10.10.2-0.3-0.30.3-0.3-0.4-0.4-0.5-0.50.50.40.40.4-0.3-0.3-0.3
Compulsive drug intake0.90.91.9-0.8-0.80.8-0.8-0.8-0.2-0.8-0.80.81.21.21.3-1.3-1.40.7
One hour access (shock baseline)0.10.21.20.00.0-0.00.1-0.0-0.5-0.2-0.20.2-0.3-0.4-0.40.60.6-1.1
Social response proportion1.21.31.91.21.2-1.21.21.21.41.41.4-1.4-1.0-0.9-0.80.70.61.2
Social responses6.98.910.73.23.2-3.23.33.22.83.13.1-3.1-3.1-3.0-3.02.82.71.2
Social time0.40.51.1-0.6-0.60.6-0.6-0.6-0.2-0.6-0.60.60.80.90.9-1.1-1.00.5
Soleus weight8.625.229.3-5.2-5.25.2-5.2-5.3-4.2-5.3-5.35.35.45.45.3-5.1-5.2-1.2
Bone: stiffness2.03.25.5-1.6-1.61.6-1.7-1.8-1.1-2.0-2.02.02.02.02.0-1.8-2.30.0
Tibialis anterior weight0.93.24.4-1.7-1.71.7-1.7-1.9-1.5-2.1-2.12.11.91.81.8-1.6-2.0-0.5
Time to tail flick, vehicle, before self-admin0.90.91.71.01.0-1.01.11.11.31.11.1-1.1-0.8-0.6-0.60.30.41.3
Time to tail flick, vehicle, after self-admin0.20.31.80.10.1-0.10.0-0.0-0.6-0.2-0.20.2-0.3-0.4-0.50.70.6-1.4
Time to tail flick, test, before self-admin0.60.61.30.80.8-0.80.80.81.10.80.8-0.8-0.5-0.4-0.30.10.21.2
Time to tail flick, test, after self-admin0.50.50.70.80.8-0.80.80.80.80.80.8-0.8-0.7-0.7-0.60.70.50.6
Delta time to tail flick, vehicle, before/after SA1.11.13.5-1.0-1.01.0-1.1-1.1-1.6-1.3-1.31.30.60.40.30.0-0.2-1.9
Delta time to tail flick, test, before/after SA0.20.20.80.10.1-0.10.10.1-0.30.00.0-0.0-0.4-0.5-0.60.80.6-0.9
Tibia length0.71.92.71.31.3-1.31.41.30.91.31.3-1.3-1.6-1.6-1.61.61.6-0.1
Ambulatory time before self-admin0.40.41.0-0.6-0.60.6-0.7-0.6-0.2-0.5-0.50.50.80.80.8-1.0-0.80.4
Ambulatory time after self-admin0.30.40.50.60.6-0.60.60.70.70.70.7-0.7-0.6-0.6-0.50.40.40.5
Bone: tissue strength1.41.32.2-1.1-1.11.1-1.1-1.1-0.6-1.0-1.01.01.41.41.5-1.5-1.50.3
Total heroin consumption1.82.22.51.51.5-1.51.51.61.21.61.6-1.6-1.6-1.6-1.51.41.50.3
Bone: trabecular number1.32.03.71.71.7-1.71.71.71.91.51.5-1.5-1.1-0.9-0.80.60.41.5
Bone: trabecular spacing2.22.97.0-1.9-1.91.9-1.9-1.9-2.6-1.8-1.81.81.00.70.5-0.1-0.1-2.6
Bone: trabecular thickness1.62.010.21.21.2-1.21.21.22.31.21.2-1.2-0.00.40.6-1.1-1.03.2
Bone: trabecular tissue density1.52.12.5-1.6-1.61.6-1.6-1.6-1.3-1.6-1.61.61.51.41.4-1.1-1.4-0.5
Water consumed over 24 hours0.50.61.3-0.7-0.70.7-0.7-0.7-0.2-0.6-0.60.60.80.90.9-0.9-1.10.7
Number of responses in last shaping day0.10.10.20.40.4-0.40.40.30.20.20.2-0.2-0.3-0.3-0.30.30.4-0.2