Rela

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Rela 0.14 0.09 6.3e-03 0.05 0.07 0.01 0.03 2.5e-02 9.9e-03 1.5e-01 7.1e-02
2 Liver gene expression Rela 0.17 0.08 5.3e-11 0.1 0.09 0.1 0.09 7.3e-11 2.7e-10 1.1e-10 1.6e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.10.10.20.5-0.1
Area under the delay curve0.10.10.2-0.5-0.2
BMI with tail0.82.82.91.6-1.7
BMI without tail0.10.80.80.9-0.9
Body weight1.35.510.63.30.7
Weight adjusted by age0.71.92.81.71.0
Bone surface2.65.08.22.91.4
Bone volume0.71.42.61.60.5
Breakpoint value in progressive ratio session1.93.54.82.21.5
Number of licking bursts0.10.30.60.70.2
Context. condit. distance diff. score1.92.33.2-1.8-1.2
Locomotion velocity, session 10.00.00.1-0.10.3
Locomotion distance, session 10.30.40.60.3-0.8
Locomotion velocity, session 21.21.42.71.70.3
Locomotion distance, session 20.30.40.50.6-0.7
Locomotion velocity, session 30.81.01.5-0.7-1.2
Locomotion distance, session 30.00.00.0-0.2-0.0
Stereotopy head waving bouts, day 32.42.94.1-1.3-2.0
Stereotopy head waving duration, day 31.51.82.1-1.2-1.4
Locomotion velocity, session 72.02.23.8-0.8-2.0
Locomotion distance, session 70.60.81.5-0.4-1.2
Stereotopy head waving bouts, day 70.10.10.2-0.1-0.4
Stereotopy head waving duration, day 70.30.40.70.80.3
Locomotion velocity, session 80.60.70.90.90.7
Locomotion distance, session 81.01.52.4-0.8-1.5
Degree of sensitization distance0.90.91.8-0.2-1.3
Degree of sensitization stereotypy0.40.50.70.80.5
Conditioned locomotion1.31.52.01.41.0
Cocaine response after cond. corrected1.21.82.2-1.5-1.2
Cocaine response after cond. not corrected1.01.41.6-1.3-1.1
Cocaine response before conditioning0.70.81.31.10.6
Saline control response2.33.25.02.21.2
Bone: connectivity density1.01.52.61.60.6
Bone: cortical apparent density0.30.50.90.41.0
Bone: cortical area0.81.31.81.30.9
Bone: cortical porosity0.00.00.10.20.2
Bone: cortical porosity0.20.20.40.60.3
Bone: cortical thickness4.16.97.42.52.7
Bone: cortical thickness0.91.21.70.81.3
Bone: cortical tissue density0.50.81.20.61.1
Condit. Reinf. active minus inactive responses0.10.10.20.3-0.4
Condit. Reinf. active-inactive response ratio0.10.10.10.10.4
Condit. Reinf. active responses0.40.50.90.1-1.0
Condit. Reinf. inactive responses1.01.32.5-0.2-1.6
Incentive salience index mean0.30.30.50.4-0.7
Condit. Reinf. lever presses0.30.40.70.8-0.4
Condit. Reinf. active minus inactive responses0.00.00.1-0.1-0.2
Condit. Reinf. active-inactive response ratio0.40.60.9-0.6-1.0
Condit. Reinf. active responses0.00.10.10.30.1
Condit. Reinf. inactive responses0.10.20.20.50.4
Condit. Reinf. lever presses1.72.43.61.91.1
Condit. Reinf. lever reinforcers received0.20.30.50.70.4
Conditioned reinforcement - actives0.00.10.30.50.1
Conditioned reinforcement - inactives0.61.62.6-1.6-0.7
Conditioned locomotion3.75.68.7-2.9-1.6
Patch foraging indifference point 0 sec0.00.00.0-0.2-0.2
Patch foraging indifference point AUC1.94.64.72.22.1
Delay disc. indifference point, 0s delay0.91.01.2-1.1-0.9
Delay disc. indifference point, 16s delay0.50.70.9-0.9-0.7
Delay disc. indifference point, 2s delay0.40.40.6-0.5-0.8
Delay disc. indifference point, 24s delay0.10.10.1-0.30.2
Delay disc. indifference point, 4s delay0.50.50.5-0.7-0.7
Delay disc. indifference point, 8s delay0.10.10.2-0.50.1
Indifference point function ln k4.212.614.6-3.8-3.3
Indifference point function log k4.212.614.6-3.8-3.3
Patch foraging total patch changes 0 sec0.00.00.0-0.10.1
Patch foraging total patch changes 12 sec3.75.06.62.61.8
Patch foraging total patch changes 18 sec0.20.50.90.90.5
Patch foraging total patch changes 24 sec0.93.03.51.91.6
Patch foraging total patch changes 6 sec0.50.91.31.20.6
Patch foraging time to switch 0 sec0.31.01.91.4-0.2
Patch foraging water rate 0 sec0.72.75.1-2.3-0.5
Patch foraging water rate 12 sec2.08.113.9-3.7-1.5
Patch foraging water rate 18 sec1.53.35.0-2.2-1.3
Patch foraging water rate 24 sec2.63.86.0-2.4-1.3
Patch foraging water rate 6 sec2.63.86.3-2.5-1.2
Seeking ratio, delayed vs. immediate footshock0.40.50.8-0.5-0.9
Distance traveled before self-admin0.20.50.90.90.4
Distance traveled after self-admin0.61.11.70.71.3
Extensor digitorum longus weight5.421.732.75.73.3
Bone: elastic displacement0.30.40.7-0.80.2
Bone: elastic work1.11.41.71.11.3
Bone: endosteal estimation1.84.36.3-1.5-2.5
Bone: endosteal perimeter1.64.05.8-1.5-2.4
Epididymis fat weight1.89.010.2-3.2-2.8
Delta time in closed arm before/after self-admin0.00.00.00.00.1
Delta time in open arm before/after self-admin0.70.91.10.81.0
Diff in mean of infusions in LGA sessions0.40.60.90.90.6
Delay discount exponential model param0.10.10.10.40.1
Extinction: sum of active levers before priming1.01.42.81.70.4
Active lever presses in extinction session 62.82.84.72.20.9
Bone: final force1.72.84.32.11.1
Bone: final moment1.62.63.92.01.1
Food consumed during 24 hour testing period0.50.91.60.51.3
Glucose3.86.16.2-2.4-2.5
Heart weight3.45.46.9-2.0-2.6
Delay discount hyperbolic model param0.10.10.10.40.2
Intermittent access intake day 1-15 change0.10.50.9-0.9-0.4
Intermittent access intake escalation0.10.30.5-0.7-0.2
Intermittent access intake escalation 20.10.20.5-0.7-0.0
Intermitt. access day 1 inactive lever presses0.00.10.2-0.30.4
Intermitt. access day 15 inactive lever presses0.21.31.7-1.3-1.0
Intermitt. access escalation Index1.34.15.4-2.3-1.7
Intermittent access day 1 total infusions2.26.68.5-2.2-2.9
Intermittent access day 15 total infusions2.56.06.1-2.5-2.4
Intermittent access terminal intake (last 3 days)3.56.07.0-2.3-2.6
Intermittent access total infusions5.26.17.8-2.1-2.8
Intermittent access day 1 locomotion2.44.35.3-1.8-2.3
Intermittent access day 15 total locomotion1.14.34.6-2.1-2.0
Intermittent access total locomotion7.28.69.7-2.8-3.1
Intermittent access standard deviation0.10.71.4-1.2-0.2
Left kidney weight0.43.03.2-1.8-1.7
Right kidney weight0.10.71.1-1.1-0.6
Cocaine induced anxiety0.00.10.10.30.2
Post-drug Anxiety0.60.71.21.10.4
Baseline Anxiety0.10.20.30.60.4
Tail length0.52.53.31.31.8
Length with tail1.88.09.23.02.6
Length without tail1.26.27.02.62.3
Times rat made contact with spout0.50.50.80.50.9
Lifetime Intake4.15.06.5-1.9-2.6
Liver weight, left0.71.21.7-1.3-0.8
Liver weight, right2.54.45.4-2.3-1.8
Locomotor activity1.11.73.3-1.8-0.4
Locomotor testing distance1.02.44.6-2.1-0.5
Locomotor testing rearing0.72.65.2-2.3-0.2
Locomotion in novel chamber4.35.86.6-2.6-2.2
Locomotion in novel chamber post-restriction1.03.13.9-2.0-1.5
Fecal boli incidents, locomotor time 10.10.20.20.50.4
Change in fecal boli incidents, locomotor task0.60.61.0-0.4-1.0
Time >=10cm from walls, locomotor time 11.61.93.2-0.8-1.8
Bouts of movement, locomotor time 13.34.35.91.62.4
Total resting periods, locomotor time 12.63.04.11.42.0
Rest time, locomotor task time 10.40.61.2-1.1-0.1
Distance moved, locomotor task time 10.20.51.10.0-1.0
Vertical activity count, locomotor time 10.21.21.3-1.1-1.1
Time >=10cm from walls, locomotor time 20.10.20.20.40.4
Bouts of movement, locomotor time 20.31.11.40.81.2
Total resting periods, locomotor time 20.10.50.80.50.9
Rest time, locomotor task time 21.11.83.0-1.7-0.8
Distance moved, locomotor task time 20.91.21.71.30.8
Vertical activity count, locomotor time 20.00.10.10.10.4
Light reinforcement 10.00.20.2-0.30.5
Light reinforcement 20.10.30.4-0.6-0.5
Bone: marrow area2.04.87.1-1.6-2.7
Bone: maximum diameter0.20.40.60.80.2
Bone: maximum force1.63.25.82.40.7
Bone: maximum moment1.52.95.22.30.7
Mean time between licks in bursts0.00.00.10.30.0
Mean num. licks in bursts0.10.30.5-0.70.1
Cd content in liver0.50.50.9-1.0-0.4
Co content in liver0.70.91.4-1.20.6
Cu content in liver0.00.00.0-0.1-0.1
Fe content in liver0.10.10.20.40.3
K content in liver0.10.10.20.4-0.1
Mg content in liver0.80.91.1-0.9-1.0
Mn content in liver2.73.05.02.21.1
Na content in liver1.21.31.90.91.4
Rb content in liver1.92.23.5-1.9-0.9
Se content in liver0.10.10.1-0.2-0.3
Sr content in liver4.13.53.71.81.9
Zn content in liver0.20.20.20.40.5
Bone: minimum diameter1.73.24.4-1.4-2.1
Time in familiar zone, hab. session 10.80.91.5-0.6-1.2
Time in novel zone, hab. session 10.20.20.3-0.40.5
Total zone transitions, hab. session 10.40.50.90.90.3
Total locomotion distance, hab. session 10.70.91.4-0.7-1.2
Locomotion velocity, hab. session 10.20.20.4-0.2-0.6
Time in familiar zone, hab. session 20.00.00.0-0.20.1
Time in novel zone, hab. session 20.00.00.00.2-0.1
Total zone transitions, hab. session 20.50.60.60.8-0.8
Total locomotion distance, hab. session 21.11.42.6-0.5-1.6
Locomotion velocity, hab. session 21.41.83.2-0.7-1.8
Novel to familiar place preference ratio0.70.91.71.30.4
Novelty place preference0.30.40.70.90.3
Time in novel zone, NPP test0.20.30.50.70.2
Total zone transitions, NPP test1.01.52.81.70.5
Total locomotion distance, NPP test0.20.20.5-0.0-0.7
Locomotion velocity, NPP test0.10.10.20.1-0.5
Intraocular pressure0.20.40.5-0.70.5
Delta distance traveled before/after self-admin0.30.30.4-0.40.7
Delta ambulatory time before/after self-admin0.20.30.5-0.20.7
Parametrial fat weight3.89.09.2-3.0-2.9
Pavlov. Cond. lever latency0.20.20.2-0.50.4
Pavlov. Cond. magazine entry latency0.20.20.20.4-0.5
Pavlov. Cond. change in total contacts0.10.10.20.5-0.2
Pavlov. Cond. index score0.10.20.40.60.1
Pavlov. Cond. latency score0.10.10.10.4-0.3
Pavlov. Cond. lever contacts0.20.20.40.2-0.6
Pavlov. Cond. magazine entry number0.50.60.7-0.8-0.7
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.5-0.2
Pavlov. Cond. lever-magazine prob. diff.0.20.30.60.80.1
Pavlov. Cond. response bias0.20.30.50.70.3
Pavlov. Cond. lever latency0.71.01.4-1.2-0.8
Pavlov. Cond. magazine entry latency2.83.95.82.41.4
Pavlov. Cond. change in total contacts0.92.13.51.90.8
Pavlov. Cond. index score1.82.84.42.11.1
Pavlov. Cond. latency score1.42.33.82.00.9
Pavlov. Cond. lever contacts0.71.01.41.20.8
Pavlov. Cond. magazine entry number5.67.310.6-3.3-2.0
Pavlov. Cond. intertrial magazine entries0.51.11.5-1.2-0.8
Pavlov. Cond. lever-magazine prob. diff.2.23.35.32.31.2
Pavlov. Cond. response bias1.92.63.71.91.2
Time in closed arm before self-admin0.30.50.9-0.4-0.9
Time in closed arm after self-admin0.70.81.1-0.7-1.0
Time in open arm before self-admin0.40.50.7-0.9-0.4
Time in open arm after self-admin0.50.61.10.21.0
Bone: periosteal estimation0.20.40.90.0-0.9
Bone: periosteal perimeter0.10.20.20.4-0.5
Bone: post-yield work1.72.95.60.5-2.4
Progressive ratio test 1 active lever presses0.10.20.2-0.4-0.5
Progressive ratio test 1 breakpoint0.10.10.2-0.3-0.4
Progressive ratio test 1 inactive lever presses0.00.00.0-0.20.2
Progressive ratio test 2 active lever presses1.52.12.2-1.5-1.4
Progressive ratio test 2 breakpoint1.52.02.0-1.4-1.4
Progressive ratio test 2 inactive lever presses2.47.79.4-3.1-2.4
Incentive Sensitization - Responses0.20.50.9-0.1-1.0
Incentive Sensitization - Breakpoint0.20.61.1-0.2-1.0
Sum of active levers in priming session hrs 5-63.73.53.71.91.8
Progressive ratio0.20.60.70.7-0.9
Food seeking constrained by brief footshock0.10.10.10.2-0.3
Seeking ratio, punishment vs. effort0.30.81.5-1.20.0
Retroperitoneal fat weight8.337.347.0-6.9-5.2
Reaction time number correct0.20.60.60.70.8
Reaction time mean minus median0.63.76.22.51.1
Reaction time mean minus median AUC0.42.43.61.91.1
Reaction time num false alarms0.30.50.7-0.8-0.5
Reaction time num false alarms AUC0.00.00.0-0.2-0.2
Reaction time trials correct on left0.20.60.60.70.8
Reaction time trials on left0.20.70.70.90.8
Reaction time mean0.00.10.20.40.2
Reaction time mean AUC0.00.10.10.30.1
Median of all reaction times0.00.10.1-0.2-0.2
Reaction time omissions1.42.23.41.81.0
Reaction time false alarm rate0.40.60.6-0.8-0.7
Reaction time premature initiation rate1.52.32.71.61.4
Reaction time premature initiations1.75.35.42.32.3
Std. dev. reaction times0.41.22.01.40.6
Reaction time trials completed0.20.70.70.90.8
Reaction time trials AUC0.10.40.40.60.6
Run reversals in cocaine runway, females0.70.81.6-0.0-1.2
Run reversals in cocaine runway, males0.20.20.3-0.30.6
Latency to leave start box in cocaine runway0.60.81.3-0.4-1.2
Latency to leave start box in cocaine runway, F0.10.10.1-0.3-0.4
Latency to leave start box in cocaine runway, M0.60.61.10.0-1.1
Std. dev. time between licks in bursts0.00.10.1-0.3-0.2
Total sessions with >9 infusions0.60.71.4-0.2-1.2
Short access day 1 total inactive lever presses1.53.03.4-1.8-1.6
Short access day 10 total inactive lever presses0.10.60.8-0.9-0.5
Short access day 1 total infusions1.93.74.7-1.7-2.2
Short access day 10 total infusions2.03.45.8-1.0-2.4
Short access total infusions2.13.05.0-1.0-2.2
Short access day 1 locomotion1.72.93.4-1.5-1.8
Short access day 10 total locomotion0.52.02.5-1.2-1.6
Short access total locomotion1.82.73.5-1.4-1.9
One hour access (0.3 mA shock)5.76.78.4-2.9-2.2
Compulsive drug intake2.03.04.41.32.1
One hour access (shock baseline)2.97.68.4-2.9-2.6
Social response proportion0.50.70.91.00.7
Social responses0.40.50.70.60.8
Social time0.40.60.80.70.9
Soleus weight3.19.313.4-3.7-2.3
Bone: stiffness1.32.44.02.00.8
Tibialis anterior weight9.532.743.56.64.7
Time to tail flick, vehicle, before self-admin0.30.40.70.3-0.8
Time to tail flick, vehicle, after self-admin0.30.51.00.2-1.0
Time to tail flick, test, before self-admin3.94.55.2-1.9-2.3
Time to tail flick, test, after self-admin0.10.10.10.40.2
Delta time to tail flick, vehicle, before/after SA0.00.00.10.30.0
Delta time to tail flick, test, before/after SA4.75.87.52.02.7
Tibia length1.64.55.62.41.8
Ambulatory time before self-admin0.10.40.70.80.2
Ambulatory time after self-admin0.10.10.1-0.30.2
Bone: tissue strength0.10.10.10.0-0.3
Total heroin consumption5.05.87.42.72.1
Bone: trabecular number0.20.40.80.90.2
Bone: trabecular spacing0.30.50.8-0.9-0.4
Bone: trabecular thickness0.40.60.6-0.8-0.7
Bone: trabecular tissue density1.93.35.2-2.3-1.2
Water consumed over 24 hours1.02.02.61.11.6
Number of responses in last shaping day0.10.20.4-0.10.6