Rela

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Rela 0.14 0.09 6.3e-03 0.05 0.07 0.01 0.03 2.5e-02 9.9e-03 1.5e-01 7.5e-02
2 Liver gene expression Rela 0.17 0.08 5.3e-11 0.1 0.09 0.1 0.09 7.3e-11 2.7e-10 1.1e-10 1.7e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.10.10.20.50.1
Area under the delay curve0.10.10.2-0.50.2
BMI with tail0.82.82.91.61.7
BMI without tail0.30.80.80.90.9
Body weight1.35.510.63.3-0.7
Weight adjusted by age1.31.92.81.7-1.0
Bone surface2.85.08.22.9-1.4
Bone volume0.81.42.61.6-0.5
Breakpoint value in progressive ratio session2.93.54.82.2-1.5
Number of licking bursts0.20.30.60.7-0.2
Context. condit. distance diff. score1.92.33.2-1.81.2
Locomotion velocity, session 10.00.00.1-0.1-0.3
Locomotion distance, session 10.30.40.60.30.8
Locomotion velocity, session 21.21.42.71.7-0.3
Locomotion distance, session 20.30.40.50.60.7
Locomotion velocity, session 30.81.01.5-0.71.2
Locomotion distance, session 30.00.00.0-0.20.0
Stereotopy head waving bouts, day 32.42.94.1-1.32.0
Stereotopy head waving duration, day 31.51.82.1-1.21.4
Locomotion velocity, session 72.12.23.8-0.82.0
Locomotion distance, session 70.70.81.5-0.41.2
Stereotopy head waving bouts, day 70.10.10.2-0.10.4
Stereotopy head waving duration, day 70.30.40.70.8-0.3
Locomotion velocity, session 80.60.70.90.9-0.7
Locomotion distance, session 81.01.52.4-0.81.5
Degree of sensitization distance0.90.91.8-0.21.3
Degree of sensitization stereotypy0.40.50.70.8-0.5
Conditioned locomotion1.31.52.01.4-1.0
Cocaine response after cond. corrected1.51.82.2-1.51.2
Cocaine response after cond. not corrected1.21.41.6-1.31.1
Cocaine response before conditioning0.70.81.31.1-0.6
Saline control response2.43.25.02.2-1.2
Bone: connectivity density1.01.52.61.6-0.6
Bone: cortical apparent density0.40.50.90.4-1.0
Bone: cortical area0.81.31.81.3-0.9
Bone: cortical porosity0.00.00.10.2-0.2
Bone: cortical porosity0.20.20.40.6-0.3
Bone: cortical thickness4.16.97.42.5-2.7
Bone: cortical thickness1.01.21.70.8-1.3
Bone: cortical tissue density0.60.81.20.6-1.1
Condit. Reinf. active minus inactive responses0.10.10.20.30.4
Condit. Reinf. active-inactive response ratio0.10.10.10.1-0.4
Condit. Reinf. active responses0.40.50.90.11.0
Condit. Reinf. inactive responses1.11.32.5-0.21.6
Incentive salience index mean0.30.30.50.40.7
Condit. Reinf. lever presses0.30.40.70.80.4
Condit. Reinf. active minus inactive responses0.00.00.1-0.10.2
Condit. Reinf. active-inactive response ratio0.50.60.9-0.61.0
Condit. Reinf. active responses0.00.10.10.3-0.1
Condit. Reinf. inactive responses0.10.20.20.5-0.4
Condit. Reinf. lever presses1.72.43.61.9-1.1
Condit. Reinf. lever reinforcers received0.20.30.50.7-0.4
Conditioned reinforcement - actives0.10.10.30.5-0.1
Conditioned reinforcement - inactives1.11.62.6-1.60.7
Conditioned locomotion4.35.68.7-2.91.6
Patch foraging indifference point 0 sec0.00.00.0-0.20.2
Patch foraging indifference point AUC3.24.64.72.2-2.1
Delay disc. indifference point, 0s delay0.91.01.2-1.10.9
Delay disc. indifference point, 16s delay0.60.70.9-0.90.7
Delay disc. indifference point, 2s delay0.40.40.6-0.50.8
Delay disc. indifference point, 24s delay0.10.10.1-0.3-0.2
Delay disc. indifference point, 4s delay0.50.50.5-0.70.7
Delay disc. indifference point, 8s delay0.10.10.2-0.5-0.1
Indifference point function ln k7.212.614.6-3.83.3
Indifference point function log k7.212.614.6-3.83.3
Patch foraging total patch changes 0 sec0.00.00.0-0.1-0.1
Patch foraging total patch changes 12 sec3.85.06.62.6-1.8
Patch foraging total patch changes 18 sec0.30.50.90.9-0.5
Patch foraging total patch changes 24 sec1.73.03.51.9-1.6
Patch foraging total patch changes 6 sec0.60.91.31.2-0.6
Patch foraging time to switch 0 sec0.51.01.91.40.2
Patch foraging water rate 0 sec1.32.75.1-2.30.5
Patch foraging water rate 12 sec3.98.113.9-3.71.5
Patch foraging water rate 18 sec2.23.35.0-2.21.3
Patch foraging water rate 24 sec2.73.86.0-2.41.3
Patch foraging water rate 6 sec2.63.86.3-2.51.2
Seeking ratio, delayed vs. immediate footshock0.40.50.8-0.50.9
Distance traveled before self-admin0.40.50.90.9-0.4
Distance traveled after self-admin0.91.11.70.7-1.3
Extensor digitorum longus weight5.521.732.75.7-3.3
Bone: elastic displacement0.30.40.7-0.8-0.2
Bone: elastic work1.11.41.71.1-1.3
Bone: endosteal estimation2.04.36.3-1.52.5
Bone: endosteal perimeter1.94.05.8-1.52.4
Epididymis fat weight2.69.010.2-3.22.8
Delta time in closed arm before/after self-admin0.00.00.00.0-0.1
Delta time in open arm before/after self-admin0.90.91.10.8-1.0
Diff in mean of infusions in LGA sessions0.50.60.90.9-0.6
Delay discount exponential model param0.10.10.10.4-0.1
Extinction: sum of active levers before priming1.31.42.81.7-0.4
Active lever presses in extinction session 62.82.84.72.2-0.9
Bone: final force1.72.84.32.1-1.1
Bone: final moment1.62.63.92.0-1.1
Food consumed during 24 hour testing period0.70.91.60.5-1.3
Glucose3.96.16.2-2.42.5
Heart weight3.55.46.9-2.02.6
Delay discount hyperbolic model param0.10.10.10.4-0.2
Intermittent access intake day 1-15 change0.30.50.9-0.90.4
Intermittent access intake escalation0.10.30.5-0.70.2
Intermittent access intake escalation 20.20.20.5-0.70.0
Intermitt. access day 1 inactive lever presses0.00.10.2-0.3-0.4
Intermitt. access day 15 inactive lever presses0.71.31.7-1.31.0
Intermitt. access escalation Index2.94.15.4-2.31.7
Intermittent access day 1 total infusions4.16.68.5-2.22.9
Intermittent access day 15 total infusions4.06.06.1-2.52.4
Intermittent access terminal intake (last 3 days)4.66.07.0-2.32.6
Intermittent access total infusions5.26.17.8-2.12.8
Intermittent access day 1 locomotion3.44.35.3-1.82.3
Intermittent access day 15 total locomotion2.44.34.6-2.12.0
Intermittent access total locomotion7.28.69.7-2.83.1
Intermittent access standard deviation0.40.71.4-1.20.2
Left kidney weight0.63.03.2-1.81.7
Right kidney weight0.20.71.1-1.10.6
Cocaine induced anxiety0.10.10.10.3-0.2
Post-drug Anxiety0.60.71.21.1-0.4
Baseline Anxiety0.20.20.30.6-0.4
Tail length0.72.53.31.3-1.8
Length with tail1.88.09.23.0-2.6
Length without tail1.96.27.02.6-2.3
Times rat made contact with spout0.50.50.80.5-0.9
Lifetime Intake4.15.06.5-1.92.6
Liver weight, left0.71.21.7-1.30.8
Liver weight, right2.54.45.4-2.31.8
Locomotor activity1.11.73.3-1.80.4
Locomotor testing distance1.32.44.6-2.10.5
Locomotor testing rearing1.32.65.2-2.30.2
Locomotion in novel chamber4.55.86.6-2.62.2
Locomotion in novel chamber post-restriction1.93.13.9-2.01.5
Fecal boli incidents, locomotor time 10.10.20.20.5-0.4
Change in fecal boli incidents, locomotor task0.60.61.0-0.41.0
Time >=10cm from walls, locomotor time 11.81.93.2-0.81.8
Bouts of movement, locomotor time 13.84.35.91.6-2.4
Total resting periods, locomotor time 12.73.04.11.4-2.0
Rest time, locomotor task time 10.50.61.2-1.10.1
Distance moved, locomotor task time 10.40.51.10.01.0
Vertical activity count, locomotor time 10.51.21.3-1.11.1
Time >=10cm from walls, locomotor time 20.10.20.20.4-0.4
Bouts of movement, locomotor time 20.71.11.40.8-1.2
Total resting periods, locomotor time 20.30.50.80.5-0.9
Rest time, locomotor task time 21.51.83.0-1.70.8
Distance moved, locomotor task time 21.01.21.71.3-0.8
Vertical activity count, locomotor time 20.10.10.10.1-0.4
Light reinforcement 10.10.20.2-0.3-0.5
Light reinforcement 20.20.30.4-0.60.5
Bone: marrow area2.24.87.1-1.62.7
Bone: maximum diameter0.20.40.60.8-0.2
Bone: maximum force1.83.25.82.4-0.7
Bone: maximum moment1.62.95.22.3-0.7
Mean time between licks in bursts0.00.00.10.3-0.0
Mean num. licks in bursts0.20.30.5-0.7-0.1
Cd content in liver0.50.50.9-1.00.4
Co content in liver0.70.91.4-1.2-0.6
Cu content in liver0.00.00.0-0.10.1
Fe content in liver0.10.10.20.4-0.3
K content in liver0.10.10.20.40.1
Mg content in liver0.90.91.1-0.91.0
Mn content in liver2.83.05.02.2-1.1
Na content in liver1.31.31.90.9-1.4
Rb content in liver1.92.23.5-1.90.9
Se content in liver0.10.10.1-0.20.3
Sr content in liver4.13.53.71.8-1.9
Zn content in liver0.20.20.20.4-0.5
Bone: minimum diameter1.73.24.4-1.42.1
Time in familiar zone, hab. session 11.00.91.5-0.61.2
Time in novel zone, hab. session 10.20.20.3-0.4-0.5
Total zone transitions, hab. session 10.40.50.90.9-0.3
Total locomotion distance, hab. session 10.70.91.4-0.71.2
Locomotion velocity, hab. session 10.20.20.4-0.20.6
Time in familiar zone, hab. session 20.00.00.0-0.2-0.1
Time in novel zone, hab. session 20.00.00.00.20.1
Total zone transitions, hab. session 20.50.60.60.80.8
Total locomotion distance, hab. session 21.11.42.6-0.51.6
Locomotion velocity, hab. session 21.41.83.2-0.71.8
Novel to familiar place preference ratio0.90.91.71.3-0.4
Novelty place preference0.40.40.70.9-0.3
Time in novel zone, NPP test0.30.30.50.7-0.2
Total zone transitions, NPP test1.01.52.81.7-0.5
Total locomotion distance, NPP test0.20.20.5-0.00.7
Locomotion velocity, NPP test0.10.10.20.10.5
Intraocular pressure0.30.40.5-0.7-0.5
Delta distance traveled before/after self-admin0.30.30.4-0.4-0.7
Delta ambulatory time before/after self-admin0.20.30.5-0.2-0.7
Parametrial fat weight3.89.09.2-3.02.9
Pavlov. Cond. lever latency0.20.20.2-0.5-0.4
Pavlov. Cond. magazine entry latency0.20.20.20.40.5
Pavlov. Cond. change in total contacts0.10.10.20.50.2
Pavlov. Cond. index score0.10.20.40.6-0.1
Pavlov. Cond. latency score0.10.10.10.40.3
Pavlov. Cond. lever contacts0.20.20.40.20.6
Pavlov. Cond. magazine entry number0.50.60.7-0.80.7
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.50.2
Pavlov. Cond. lever-magazine prob. diff.0.20.30.60.8-0.1
Pavlov. Cond. response bias0.20.30.50.7-0.3
Pavlov. Cond. lever latency0.71.01.4-1.20.8
Pavlov. Cond. magazine entry latency3.23.95.82.4-1.4
Pavlov. Cond. change in total contacts1.32.13.51.9-0.8
Pavlov. Cond. index score2.12.84.42.1-1.1
Pavlov. Cond. latency score1.72.33.82.0-0.9
Pavlov. Cond. lever contacts0.81.01.41.2-0.8
Pavlov. Cond. magazine entry number5.97.310.6-3.32.0
Pavlov. Cond. intertrial magazine entries0.71.11.5-1.20.8
Pavlov. Cond. lever-magazine prob. diff.2.53.35.32.3-1.2
Pavlov. Cond. response bias1.92.63.71.9-1.2
Time in closed arm before self-admin0.40.50.9-0.40.9
Time in closed arm after self-admin0.70.81.1-0.71.0
Time in open arm before self-admin0.40.50.7-0.90.4
Time in open arm after self-admin0.50.61.10.2-1.0
Bone: periosteal estimation0.20.40.90.00.9
Bone: periosteal perimeter0.10.20.20.40.5
Bone: post-yield work2.02.95.60.52.4
Progressive ratio test 1 active lever presses0.20.20.2-0.40.5
Progressive ratio test 1 breakpoint0.10.10.2-0.30.4
Progressive ratio test 1 inactive lever presses0.00.00.0-0.2-0.2
Progressive ratio test 2 active lever presses1.82.12.2-1.51.4
Progressive ratio test 2 breakpoint1.72.02.0-1.41.4
Progressive ratio test 2 inactive lever presses4.87.79.4-3.12.4
Incentive Sensitization - Responses0.30.50.9-0.11.0
Incentive Sensitization - Breakpoint0.40.61.1-0.21.0
Sum of active levers in priming session hrs 5-63.83.53.71.9-1.8
Progressive ratio0.40.60.70.70.9
Food seeking constrained by brief footshock0.10.10.10.20.3
Seeking ratio, punishment vs. effort0.50.81.5-1.2-0.0
Retroperitoneal fat weight8.737.347.0-6.95.2
Reaction time number correct0.30.60.60.7-0.8
Reaction time mean minus median1.53.76.22.5-1.1
Reaction time mean minus median AUC0.92.43.61.9-1.1
Reaction time num false alarms0.30.50.7-0.80.5
Reaction time num false alarms AUC0.00.00.0-0.20.2
Reaction time trials correct on left0.30.60.60.7-0.8
Reaction time trials on left0.40.70.70.9-0.8
Reaction time mean0.10.10.20.4-0.2
Reaction time mean AUC0.00.10.10.3-0.1
Median of all reaction times0.00.10.1-0.20.2
Reaction time omissions1.52.23.41.8-1.0
Reaction time false alarm rate0.40.60.6-0.80.7
Reaction time premature initiation rate1.72.32.71.6-1.4
Reaction time premature initiations2.95.35.42.3-2.3
Std. dev. reaction times0.71.22.01.4-0.6
Reaction time trials completed0.40.70.70.9-0.8
Reaction time trials AUC0.20.40.40.6-0.6
Run reversals in cocaine runway, females0.80.81.6-0.01.2
Run reversals in cocaine runway, males0.20.20.3-0.3-0.6
Latency to leave start box in cocaine runway0.70.81.3-0.41.2
Latency to leave start box in cocaine runway, F0.10.10.1-0.30.4
Latency to leave start box in cocaine runway, M0.60.61.10.01.1
Std. dev. time between licks in bursts0.10.10.1-0.30.2
Total sessions with >9 infusions0.60.71.4-0.21.2
Short access day 1 total inactive lever presses2.33.03.4-1.81.6
Short access day 10 total inactive lever presses0.20.60.8-0.90.5
Short access day 1 total infusions2.83.74.7-1.72.2
Short access day 10 total infusions2.63.45.8-1.02.4
Short access total infusions2.33.05.0-1.02.2
Short access day 1 locomotion2.32.93.4-1.51.8
Short access day 10 total locomotion1.12.02.5-1.21.6
Short access total locomotion2.32.73.5-1.41.9
One hour access (0.3 mA shock)5.86.78.4-2.92.2
Compulsive drug intake2.53.04.41.3-2.1
One hour access (shock baseline)5.07.68.4-2.92.6
Social response proportion0.60.70.91.0-0.7
Social responses0.40.50.70.6-0.8
Social time0.40.60.80.7-0.9
Soleus weight3.19.313.4-3.72.3
Bone: stiffness1.52.44.02.0-0.8
Tibialis anterior weight9.632.743.56.6-4.7
Time to tail flick, vehicle, before self-admin0.40.40.70.30.8
Time to tail flick, vehicle, after self-admin0.40.51.00.21.0
Time to tail flick, test, before self-admin4.34.55.2-1.92.3
Time to tail flick, test, after self-admin0.10.10.10.4-0.2
Delta time to tail flick, vehicle, before/after SA0.00.00.10.3-0.0
Delta time to tail flick, test, before/after SA5.75.87.52.0-2.7
Tibia length1.64.55.62.4-1.8
Ambulatory time before self-admin0.20.40.70.8-0.2
Ambulatory time after self-admin0.10.10.1-0.3-0.2
Bone: tissue strength0.10.10.10.00.3
Total heroin consumption5.05.87.42.7-2.1
Bone: trabecular number0.30.40.80.9-0.2
Bone: trabecular spacing0.30.50.8-0.90.4
Bone: trabecular thickness0.50.60.6-0.80.7
Bone: trabecular tissue density2.23.35.2-2.31.2
Water consumed over 24 hours1.52.02.61.1-1.6
Number of responses in last shaping day0.20.20.4-0.1-0.6