Hub : Genes

Rd3l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Rd3l 0.37 0.17 5.5e-09 0.28 0.31 0.3 0.31 2.3e-07 5.0e-08 7.2e-08 3.3e-08
2 Eye intron excision ratio chr6_131043426_131043787 0.21 0.16 8.4e-03 0.1 0.11 0.1 0.1 1.4e-02 9.8e-03 1.1e-02 1.3e-02
3 NAcc intron excision ratio chr6_131043426_131043787 0.05 0.04 7.2e-07 0.05 0.05 0.04 0.05 9.7e-07 6.6e-07 5.2e-06 1.2e-06
4 NAcc intron excision ratio chr6_131043405_131043787 0.05 0.04 7.3e-07 0.05 0.05 0.04 0.05 9.8e-07 6.1e-07 5.3e-06 1.2e-06
5 BLA gene expression Rd3l 0.16 0.11 1.9e-08 0.16 0.17 0.17 0.16 6.0e-09 1.6e-09 3.3e-09 3.8e-09
6 Brain gene expression Rd3l 0.08 0.07 9.1e-05 0.04 0.04 0.04 0.04 4.9e-05 8.2e-05 5.4e-05 5.9e-05
7 PL intron excision ratio chr6_131043405_131043787 0.03 0.03 2.1e-03 0.03 0.02 0.02 0.02 8.4e-04 4.0e-03 4.4e-03 4.8e-03
8 PL intron excision ratio chr6_131043426_131043787 0.03 0.03 2.9e-03 0.02 0.02 0.02 0.01 1.3e-03 6.1e-03 6.0e-03 9.0e-03
9 IL gene expression Rd3l 0.64 0.19 1.2e-10 0.34 0.38 0.4 0.39 6.2e-09 3.4e-10 1.1e-10 1.8e-10
10 Brain intron excision ratio chr6_131043405_131043787 0.08 0.07 5.6e-06 0.06 0.06 0.05 0.06 2.4e-06 4.4e-06 3.5e-05 5.6e-06
11 Brain intron excision ratio chr6_131043426_131043787 0.08 0.06 6.4e-06 0.06 0.06 0.04 0.06 4.3e-06 5.5e-06 5.2e-05 7.4e-06
12 PL gene expression Rd3l 0.36 0.17 0.0e+00 0.27 0.25 0.27 0.27 2.7e-29 1.0e-27 9.0e-30 9.2e-30

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.00.10.20.2-0.2-0.20.20.2-0.4-0.40.4-0.2-0.20.2-0.3
Area under the delay curve0.10.10.10.3-0.2-0.20.20.2-0.2-0.00.0-0.3-0.30.3-0.2
BMI with tail2.47.88.93.0-2.9-2.92.92.9-2.5-2.62.6-2.8-2.82.8-2.8
BMI without tail0.61.21.61.3-1.2-1.21.21.2-0.6-0.70.7-1.2-1.21.2-1.2
Body weight0.20.91.6-1.11.01.3-1.3-0.81.10.9-0.90.60.6-0.60.7
Weight adjusted by age0.10.10.3-0.40.30.5-0.5-0.20.0-0.00.00.2-0.00.00.1
Bone surface0.10.10.20.2-0.2-0.20.20.3-0.4-0.40.4-0.2-0.30.3-0.3
Bone volume0.00.10.10.2-0.2-0.20.20.2-0.3-0.30.3-0.2-0.30.3-0.3
Breakpoint value in progressive ratio session0.10.10.20.5-0.3-0.50.50.2-0.3-0.10.1-0.00.0-0.0-0.0
Number of licking bursts0.00.00.00.10.0-0.10.1-0.10.10.1-0.10.20.2-0.20.2
Context. condit. distance diff. score2.73.24.2-2.01.82.0-2.0-1.61.91.9-1.91.51.6-1.61.4
Locomotion velocity, session 10.20.20.2-0.40.40.5-0.5-0.40.40.4-0.40.40.5-0.50.4
Locomotion distance, session 10.50.60.90.9-0.8-0.80.80.8-0.9-0.90.9-0.6-0.60.6-0.8
Locomotion velocity, session 20.00.00.1-0.00.10.0-0.0-0.10.20.2-0.20.10.1-0.10.1
Locomotion distance, session 20.30.40.50.7-0.6-0.60.60.7-0.7-0.70.7-0.6-0.60.6-0.7
Locomotion velocity, session 30.10.10.20.4-0.4-0.40.40.4-0.4-0.50.5-0.3-0.20.2-0.4
Locomotion distance, session 30.00.00.0-0.00.10.1-0.1-0.1-0.0-0.10.10.20.2-0.20.1
Stereotopy head waving bouts, day 30.10.10.2-0.30.30.2-0.2-0.40.40.4-0.40.40.4-0.40.4
Stereotopy head waving duration, day 30.20.30.4-0.40.50.4-0.4-0.50.60.6-0.60.60.5-0.50.6
Locomotion velocity, session 70.20.30.50.4-0.5-0.50.50.4-0.7-0.70.7-0.4-0.40.4-0.4
Locomotion distance, session 70.70.91.00.9-1.0-0.90.91.0-1.0-1.01.0-1.0-1.01.0-1.0
Stereotopy head waving bouts, day 71.01.21.4-1.11.21.2-1.2-1.11.00.9-0.91.01.1-1.11.2
Stereotopy head waving duration, day 70.40.40.5-0.70.70.7-0.7-0.70.60.5-0.50.70.7-0.70.7
Locomotion velocity, session 80.40.50.8-0.80.80.9-0.9-0.60.80.8-0.80.50.6-0.60.5
Locomotion distance, session 80.10.10.2-0.40.20.4-0.50.00.30.3-0.3-0.1-0.10.1-0.3
Degree of sensitization distance0.10.10.20.3-0.4-0.40.40.3-0.4-0.40.4-0.3-0.30.3-0.3
Degree of sensitization stereotypy0.20.20.3-0.40.50.5-0.5-0.50.20.2-0.20.40.5-0.50.5
Conditioned locomotion1.41.61.8-1.21.31.3-1.3-1.31.31.2-1.21.31.3-1.31.2
Cocaine response after cond. corrected0.70.81.11.1-1.0-1.01.10.8-0.7-0.70.7-0.8-0.80.8-1.0
Cocaine response after cond. not corrected2.12.32.91.7-1.6-1.71.71.5-1.3-1.31.3-1.5-1.51.5-1.4
Cocaine response before conditioning2.12.52.81.6-1.6-1.51.51.7-1.7-1.71.7-1.7-1.71.7-1.2
Saline control response0.10.20.30.3-0.3-0.20.20.5-0.4-0.40.4-0.6-0.60.6-0.0
Bone: connectivity density0.10.10.4-0.60.50.6-0.6-0.30.10.1-0.10.30.3-0.30.2
Bone: cortical apparent density8.511.212.1-3.23.33.2-3.2-3.43.33.3-3.33.53.5-3.53.5
Bone: cortical area0.71.01.5-0.60.90.7-0.7-1.01.21.2-1.21.21.1-1.11.1
Bone: cortical porosity0.10.10.2-0.50.30.5-0.5-0.10.10.2-0.20.10.1-0.1-0.0
Bone: cortical porosity0.10.10.30.0-0.2-0.00.00.4-0.4-0.40.4-0.5-0.50.5-0.6
Bone: cortical thickness0.60.91.5-0.50.80.6-0.6-1.01.01.0-1.01.21.2-1.21.1
Bone: cortical thickness0.70.80.8-0.80.90.9-0.9-0.90.90.8-0.80.90.9-0.90.8
Bone: cortical tissue density8.711.412.3-3.23.43.2-3.2-3.53.43.4-3.43.53.5-3.53.5
Condit. Reinf. active minus inactive responses0.60.70.90.9-0.9-0.90.90.8-0.7-0.70.7-0.8-0.80.8-0.8
Condit. Reinf. active-inactive response ratio2.73.03.11.8-1.8-1.71.71.7-1.8-1.71.7-1.6-1.71.7-1.7
Condit. Reinf. active responses0.10.20.30.5-0.5-0.50.50.4-0.2-0.20.2-0.4-0.40.4-0.4
Condit. Reinf. inactive responses1.82.22.5-1.41.41.3-1.3-1.51.61.6-1.61.61.5-1.51.5
Incentive salience index mean0.60.70.80.9-0.9-0.90.90.8-0.8-0.80.8-0.7-0.70.7-0.8
Condit. Reinf. lever presses0.10.20.30.5-0.4-0.50.50.4-0.5-0.50.5-0.3-0.30.3-0.3
Condit. Reinf. active minus inactive responses0.70.81.3-1.10.91.0-1.0-0.81.11.2-1.20.70.7-0.70.5
Condit. Reinf. active-inactive response ratio0.70.81.3-1.00.80.9-0.9-0.71.11.2-1.20.60.7-0.70.1
Condit. Reinf. active responses0.10.10.3-0.30.20.2-0.2-0.10.50.5-0.5-0.0-0.00.00.1
Condit. Reinf. inactive responses0.50.60.70.8-0.8-0.80.80.9-0.6-0.70.7-0.9-0.90.9-0.2
Condit. Reinf. lever presses1.11.42.31.0-1.2-1.11.11.4-0.9-0.90.9-1.5-1.51.5-1.1
Condit. Reinf. lever reinforcers received0.10.10.3-0.40.20.4-0.4-0.10.60.6-0.6-0.1-0.10.10.0
Conditioned reinforcement - actives2.32.32.8-1.51.51.5-1.5-1.51.71.6-1.61.51.4-1.41.5
Conditioned reinforcement - inactives0.40.40.7-0.70.70.7-0.7-0.60.80.6-0.60.60.6-0.60.7
Conditioned locomotion0.50.60.70.7-0.8-0.70.70.9-0.7-0.80.8-0.9-0.80.8-0.7
Patch foraging indifference point 0 sec3.76.06.9-2.52.52.5-2.5-2.52.52.5-2.52.32.2-2.22.6
Patch foraging indifference point AUC2.42.83.3-1.41.61.5-1.5-1.81.61.7-1.71.81.8-1.81.7
Delay disc. indifference point, 0s delay0.20.20.3-0.40.40.5-0.5-0.40.50.5-0.50.30.3-0.30.4
Delay disc. indifference point, 16s delay0.10.10.20.2-0.2-0.20.20.20.30.5-0.5-0.1-0.10.1-0.1
Delay disc. indifference point, 2s delay0.20.20.60.6-0.5-0.60.60.3-0.8-0.30.3-0.3-0.40.4-0.3
Delay disc. indifference point, 24s delay0.20.20.60.5-0.4-0.40.40.3-0.8-0.50.5-0.3-0.30.3-0.3
Delay disc. indifference point, 4s delay0.20.20.3-0.50.50.5-0.5-0.40.40.5-0.50.30.4-0.40.4
Delay disc. indifference point, 8s delay0.10.10.30.2-0.3-0.20.20.4-0.3-0.30.3-0.5-0.50.5-0.4
Indifference point function ln k0.70.91.7-1.31.11.3-1.3-0.90.90.7-0.70.80.7-0.70.8
Indifference point function log k0.70.91.7-1.31.11.3-1.3-0.90.90.7-0.70.80.7-0.70.8
Patch foraging total patch changes 0 sec4.36.97.8-2.72.72.7-2.7-2.72.72.6-2.62.42.4-2.42.8
Patch foraging total patch changes 12 sec4.05.26.0-2.12.32.2-2.2-2.32.22.3-2.32.32.3-2.32.4
Patch foraging total patch changes 18 sec1.72.22.8-1.21.41.3-1.3-1.51.41.5-1.51.71.7-1.71.6
Patch foraging total patch changes 24 sec0.20.30.4-0.50.50.5-0.5-0.60.50.6-0.60.50.5-0.50.6
Patch foraging total patch changes 6 sec2.43.55.2-1.61.81.6-1.6-1.82.32.3-2.31.71.7-1.72.0
Patch foraging time to switch 0 sec11.217.317.94.1-4.2-4.04.04.2-4.2-4.24.2-4.1-4.24.2-4.2
Patch foraging water rate 0 sec19.431.133.3-5.55.65.4-5.4-5.75.75.8-5.85.55.5-5.55.8
Patch foraging water rate 12 sec10.315.818.2-4.14.04.1-4.1-3.94.34.1-4.13.73.7-3.73.9
Patch foraging water rate 18 sec5.16.87.3-2.72.72.7-2.7-2.62.52.6-2.62.52.6-2.62.7
Patch foraging water rate 24 sec4.15.86.2-2.52.52.5-2.5-2.42.42.5-2.52.32.3-2.32.4
Patch foraging water rate 6 sec5.17.58.9-2.72.72.7-2.7-2.73.02.9-2.92.62.7-2.72.7
Seeking ratio, delayed vs. immediate footshock0.30.30.6-0.50.60.6-0.6-0.50.20.1-0.10.70.7-0.70.4
Distance traveled before self-admin0.10.10.40.5-0.4-0.60.60.2-0.3-0.20.2-0.2-0.30.3-0.1
Distance traveled after self-admin0.50.60.9-0.80.70.8-0.8-0.70.90.9-0.90.70.7-0.70.6
Extensor digitorum longus weight6.425.228.7-5.35.25.3-5.4-5.05.15.0-5.04.84.7-4.74.8
Bone: elastic displacement0.50.50.6-0.70.80.8-0.8-0.80.50.7-0.70.80.7-0.70.8
Bone: elastic work0.00.10.1-0.20.30.3-0.3-0.30.20.3-0.30.30.2-0.20.3
Bone: endosteal estimation0.10.30.60.4-0.5-0.30.30.6-0.3-0.30.3-0.7-0.70.7-0.7
Bone: endosteal perimeter0.00.10.10.2-0.2-0.10.10.20.30.4-0.4-0.2-0.20.2-0.2
Epididymis fat weight4.310.010.53.2-3.2-3.13.13.2-3.1-3.13.1-3.2-3.23.2-3.2
Delta time in closed arm before/after self-admin0.00.00.1-0.1-0.10.0-0.00.2-0.0-0.10.1-0.3-0.20.2-0.4
Delta time in open arm before/after self-admin0.50.51.6-0.40.60.5-0.5-0.60.60.7-0.70.70.6-0.61.3
Diff in mean of infusions in LGA sessions0.00.00.10.2-0.1-0.20.2-0.10.00.1-0.10.10.2-0.20.1
Delay discount exponential model param0.00.00.1-0.20.10.1-0.1-0.20.20.0-0.00.20.3-0.30.2
Extinction: sum of active levers before priming0.00.00.10.2-0.2-0.30.30.1-0.1-0.00.00.00.0-0.0-0.1
Active lever presses in extinction session 61.51.51.9-1.41.21.3-1.3-1.11.21.2-1.21.11.1-1.11.2
Bone: final force0.20.40.5-0.60.60.7-0.7-0.60.70.7-0.70.60.6-0.60.5
Bone: final moment0.30.50.6-0.70.70.7-0.7-0.60.80.8-0.80.60.6-0.60.5
Food consumed during 24 hour testing period0.20.30.5-0.50.50.6-0.6-0.40.70.6-0.60.30.3-0.30.7
Glucose0.71.11.5-0.81.00.8-0.8-1.11.01.0-1.01.21.2-1.21.2
Heart weight0.00.00.0-0.10.00.1-0.10.00.0-0.00.0-0.2-0.20.2-0.0
Delay discount hyperbolic model param0.10.10.1-0.20.20.2-0.2-0.20.30.1-0.10.30.3-0.30.2
Intermittent access intake day 1-15 change1.41.41.71.3-1.3-1.31.31.2-1.1-1.11.1-1.2-1.21.2-1.0
Intermittent access intake escalation1.61.61.81.3-1.3-1.31.31.3-1.2-1.21.2-1.2-1.21.2-1.2
Intermittent access intake escalation 20.20.20.40.6-0.5-0.60.60.4-0.4-0.40.4-0.3-0.30.3-0.3
Intermitt. access day 1 inactive lever presses2.83.03.7-1.91.81.9-1.9-1.81.81.7-1.71.61.5-1.51.6
Intermitt. access day 15 inactive lever presses1.01.01.3-1.11.11.1-1.1-1.01.21.1-1.10.90.7-0.70.9
Intermitt. access escalation Index0.30.30.4-0.50.60.5-0.5-0.60.60.6-0.60.40.4-0.40.4
Intermittent access day 1 total infusions0.30.40.50.5-0.6-0.50.50.6-0.4-0.60.6-0.7-0.70.7-0.6
Intermittent access day 15 total infusions1.82.02.31.4-1.4-1.41.41.4-1.2-1.41.4-1.5-1.51.5-1.3
Intermittent access terminal intake (last 3 days)2.12.32.61.6-1.6-1.61.61.5-1.3-1.41.4-1.6-1.61.6-1.1
Intermittent access total infusions0.70.71.20.8-0.8-0.80.80.9-0.6-0.80.8-1.0-1.11.1-0.8
Intermittent access day 1 locomotion0.70.81.10.7-0.9-0.80.81.0-0.8-0.90.9-1.0-1.11.1-0.6
Intermittent access day 15 total locomotion0.20.20.30.4-0.5-0.40.40.6-0.4-0.40.4-0.6-0.60.6-0.5
Intermittent access total locomotion0.30.40.50.6-0.6-0.60.60.7-0.5-0.60.6-0.7-0.70.7-0.5
Intermittent access standard deviation3.53.74.22.1-2.0-2.02.02.0-1.8-1.81.8-1.9-1.91.9-1.7
Left kidney weight1.02.84.4-2.01.92.1-2.1-1.61.71.7-1.71.21.3-1.31.4
Right kidney weight0.61.62.8-1.61.41.7-1.7-1.11.31.2-1.20.80.8-0.81.0
Cocaine induced anxiety2.63.03.6-1.61.71.6-1.6-1.81.81.9-1.91.81.7-1.71.8
Post-drug Anxiety2.22.43.0-1.41.41.3-1.3-1.61.71.7-1.71.61.6-1.61.7
Baseline Anxiety1.51.61.91.4-1.3-1.41.41.3-1.1-1.31.3-1.2-1.11.1-1.2
Tail length3.610.812.9-3.53.43.5-3.5-3.13.63.4-3.43.03.0-3.03.1
Length with tail4.918.021.9-4.64.54.7-4.7-4.24.34.1-4.13.93.9-3.94.0
Length without tail2.35.16.5-2.52.52.6-2.6-2.31.91.9-1.92.22.2-2.22.2
Times rat made contact with spout0.30.40.7-0.30.50.3-0.3-0.60.60.7-0.70.70.7-0.70.8
Lifetime Intake0.30.30.60.5-0.5-0.50.50.6-0.3-0.40.4-0.7-0.80.8-0.4
Liver weight, left2.84.45.3-1.92.01.9-1.9-2.12.22.3-2.32.12.0-2.02.2
Liver weight, right0.00.00.0-0.10.10.1-0.1-0.10.1-0.00.00.1-0.10.10.1
Locomotor activity0.10.20.3-0.50.50.5-0.5-0.40.40.4-0.40.40.4-0.40.5
Locomotor testing distance0.40.60.8-0.70.80.8-0.8-0.80.80.7-0.70.70.7-0.70.9
Locomotor testing rearing1.21.92.51.6-1.4-1.51.51.3-1.3-1.41.4-1.3-1.41.4-1.2
Locomotion in novel chamber5.66.98.2-2.92.72.8-2.8-2.62.72.6-2.62.32.4-2.42.6
Locomotion in novel chamber post-restriction0.00.10.30.1-0.2-0.10.10.3-0.0-0.00.0-0.2-0.30.3-0.5
Fecal boli incidents, locomotor time 12.32.53.41.6-1.7-1.71.71.6-1.8-1.61.6-1.3-1.31.3-1.6
Change in fecal boli incidents, locomotor task1.11.02.0-1.41.01.3-1.3-0.71.41.1-1.10.30.3-0.30.6
Time >=10cm from walls, locomotor time 10.30.40.60.4-0.6-0.50.50.7-0.3-0.50.5-0.8-0.80.8-0.7
Bouts of movement, locomotor time 11.71.83.01.6-1.4-1.41.41.3-1.7-1.41.4-1.1-1.11.1-1.2
Total resting periods, locomotor time 11.61.82.61.6-1.3-1.41.41.3-1.6-1.41.4-1.1-1.11.1-1.2
Rest time, locomotor task time 10.10.10.30.10.20.0-0.0-0.3-0.00.1-0.10.40.5-0.50.4
Distance moved, locomotor task time 10.20.20.40.2-0.4-0.30.30.4-0.5-0.30.3-0.6-0.60.6-0.4
Vertical activity count, locomotor time 10.60.60.9-0.70.80.7-0.7-0.80.60.9-0.90.80.8-0.80.9
Time >=10cm from walls, locomotor time 20.50.50.8-0.60.70.7-0.7-0.80.60.6-0.60.70.7-0.70.9
Bouts of movement, locomotor time 22.02.12.9-1.31.41.4-1.4-1.41.41.7-1.71.41.4-1.41.4
Total resting periods, locomotor time 21.51.62.5-1.21.21.2-1.3-1.21.31.6-1.61.21.2-1.21.2
Rest time, locomotor task time 20.20.20.4-0.40.40.4-0.4-0.50.60.6-0.60.40.4-0.40.5
Distance moved, locomotor task time 20.20.20.60.5-0.4-0.50.50.4-0.7-0.60.6-0.4-0.40.4-0.3
Vertical activity count, locomotor time 20.40.40.7-0.50.60.5-0.5-0.70.20.5-0.50.80.8-0.80.8
Light reinforcement 10.00.00.0-0.00.00.1-0.10.00.10.2-0.2-0.1-0.00.0-0.0
Light reinforcement 21.72.32.81.7-1.7-1.71.71.6-1.2-1.21.2-1.5-1.41.4-1.6
Bone: marrow area0.10.20.50.3-0.4-0.30.30.6-0.3-0.30.3-0.7-0.70.7-0.7
Bone: maximum diameter0.00.10.20.5-0.2-0.40.4-0.00.20.2-0.20.20.2-0.20.1
Bone: maximum force0.20.40.6-0.50.60.6-0.6-0.60.70.7-0.70.60.6-0.60.6
Bone: maximum moment0.20.30.5-0.50.60.6-0.6-0.60.70.7-0.70.60.5-0.50.5
Mean time between licks in bursts0.60.91.40.8-1.0-0.90.81.1-0.6-0.60.6-1.2-1.21.2-1.0
Mean num. licks in bursts0.00.10.1-0.20.20.2-0.2-0.20.30.3-0.30.20.2-0.20.2
Cd content in liver0.91.02.0-1.41.11.4-1.4-0.71.01.0-1.00.50.4-0.40.9
Co content in liver1.11.31.7-1.31.21.3-1.3-1.01.31.3-1.30.91.0-1.00.9
Cu content in liver1.21.52.21.4-1.4-1.51.51.2-1.1-1.11.1-1.2-1.11.1-0.9
Fe content in liver0.30.30.60.6-0.5-0.60.60.4-0.8-0.80.8-0.4-0.30.3-0.3
K content in liver0.20.10.3-0.20.30.3-0.3-0.40.30.3-0.30.40.6-0.60.4
Mg content in liver0.20.20.5-0.40.40.4-0.4-0.40.70.7-0.70.40.6-0.60.2
Mn content in liver0.20.20.4-0.60.50.7-0.7-0.30.60.6-0.60.30.3-0.3-0.2
Na content in liver0.20.20.40.6-0.4-0.60.60.2-0.4-0.40.40.0-0.00.0-0.3
Rb content in liver0.91.11.4-1.21.11.2-1.2-1.01.11.1-1.11.01.1-1.10.7
Se content in liver0.10.10.20.4-0.3-0.20.20.4-0.4-0.40.4-0.5-0.40.4-0.0
Sr content in liver0.30.30.5-0.60.60.6-0.6-0.50.60.6-0.60.30.3-0.30.7
Zn content in liver0.20.20.3-0.30.40.4-0.4-0.40.60.6-0.60.40.4-0.40.6
Bone: minimum diameter0.81.52.1-1.21.21.3-1.3-1.11.41.5-1.51.11.1-1.11.1
Time in familiar zone, hab. session 10.30.20.40.2-0.3-0.20.20.5-0.6-0.60.6-0.6-0.60.6-0.5
Time in novel zone, hab. session 10.20.20.30.6-0.5-0.50.50.4-0.4-0.40.4-0.3-0.30.3-0.4
Total zone transitions, hab. session 10.40.60.90.5-0.7-0.50.40.8-0.7-0.70.7-0.9-0.90.9-1.0
Total locomotion distance, hab. session 10.20.20.6-0.70.50.7-0.8-0.30.50.5-0.50.10.1-0.10.1
Locomotion velocity, hab. session 10.71.01.4-1.11.01.2-1.2-0.81.11.1-1.10.70.7-0.70.8
Time in familiar zone, hab. session 20.30.30.50.4-0.5-0.40.40.6-0.6-0.60.6-0.7-0.70.7-0.5
Time in novel zone, hab. session 20.10.10.10.3-0.3-0.30.30.3-0.1-0.10.1-0.2-0.20.2-0.3
Total zone transitions, hab. session 20.81.01.11.1-1.0-1.01.01.0-1.0-1.01.0-1.0-0.90.9-1.1
Total locomotion distance, hab. session 20.30.40.5-0.50.60.6-0.6-0.60.70.7-0.70.70.7-0.70.6
Locomotion velocity, hab. session 20.50.70.8-0.70.80.8-0.8-0.80.90.9-0.90.80.9-0.90.8
Novel to familiar place preference ratio0.50.60.80.8-0.8-0.80.80.7-0.9-0.90.9-0.6-0.60.6-0.7
Novelty place preference0.30.30.50.6-0.6-0.60.60.5-0.7-0.70.7-0.4-0.50.5-0.5
Time in novel zone, NPP test0.20.30.40.5-0.5-0.50.50.5-0.6-0.60.6-0.4-0.40.4-0.5
Total zone transitions, NPP test0.10.10.3-0.0-0.10.1-0.10.3-0.3-0.30.3-0.4-0.40.4-0.5
Total locomotion distance, NPP test0.10.10.2-0.40.30.5-0.5-0.20.20.2-0.20.10.1-0.10.0
Locomotion velocity, NPP test0.10.10.3-0.40.40.5-0.5-0.20.30.3-0.30.20.2-0.20.1
Intraocular pressure0.10.10.30.2-0.2-0.20.20.2-0.5-0.50.5-0.3-0.30.3-0.3
Delta distance traveled before/after self-admin0.10.10.3-0.40.40.6-0.6-0.20.40.3-0.30.20.3-0.30.3
Delta ambulatory time before/after self-admin0.91.01.6-1.11.11.2-1.3-0.81.00.9-0.90.80.9-0.90.8
Parametrial fat weight0.00.00.00.1-0.1-0.20.20.10.0-0.20.20.0-0.00.0-0.2
Pavlov. Cond. lever latency0.81.01.2-1.01.01.0-1.0-1.01.11.1-1.10.81.0-1.00.9
Pavlov. Cond. magazine entry latency0.60.81.40.8-0.8-0.80.80.8-1.2-1.11.1-0.7-0.80.8-0.8
Pavlov. Cond. change in total contacts0.30.30.40.6-0.5-0.60.60.5-0.6-0.60.6-0.4-0.50.5-0.5
Pavlov. Cond. index score1.21.52.01.2-1.2-1.21.21.1-1.4-1.41.4-1.1-1.21.2-1.1
Pavlov. Cond. latency score0.81.01.41.0-1.0-1.01.00.9-1.2-1.11.1-0.8-0.90.9-0.9
Pavlov. Cond. lever contacts1.11.31.61.3-1.2-1.31.31.1-1.3-1.21.2-0.9-1.01.0-1.0
Pavlov. Cond. magazine entry number1.11.31.6-1.11.11.1-1.1-1.11.31.2-1.21.11.2-1.21.2
Pavlov. Cond. intertrial magazine entries6.07.38.5-2.72.72.7-2.7-2.62.92.8-2.82.62.6-2.62.6
Pavlov. Cond. lever-magazine prob. diff.0.91.11.61.1-1.0-1.11.11.0-1.3-1.21.2-0.9-1.01.0-1.0
Pavlov. Cond. response bias1.31.51.81.2-1.2-1.21.21.2-1.3-1.31.3-1.2-1.31.3-1.2
Pavlov. Cond. lever latency1.72.33.1-1.41.61.4-1.4-1.71.31.3-1.31.81.8-1.81.5
Pavlov. Cond. magazine entry latency4.55.26.12.3-2.3-2.22.22.4-2.1-2.22.2-2.5-2.42.4-2.1
Pavlov. Cond. change in total contacts3.75.15.62.3-2.3-2.32.32.4-2.1-2.12.1-2.4-2.42.4-2.1
Pavlov. Cond. index score4.25.46.82.2-2.4-2.22.22.5-2.0-2.12.1-2.6-2.62.6-2.3
Pavlov. Cond. latency score4.35.36.42.2-2.4-2.22.22.5-2.1-2.12.1-2.5-2.52.5-2.3
Pavlov. Cond. lever contacts2.53.44.41.8-1.9-1.81.82.1-1.5-1.61.6-2.1-2.12.1-1.8
Pavlov. Cond. magazine entry number3.34.04.9-2.02.12.0-2.0-2.21.71.8-1.82.22.2-2.22.1
Pavlov. Cond. intertrial magazine entries5.77.57.9-2.72.82.7-2.7-2.82.72.7-2.72.82.8-2.82.8
Pavlov. Cond. lever-magazine prob. diff.4.76.07.42.4-2.5-2.42.32.7-2.1-2.22.2-2.7-2.72.7-2.4
Pavlov. Cond. response bias3.24.35.82.0-2.1-1.91.92.3-1.7-1.81.8-2.4-2.42.4-2.0
Time in closed arm before self-admin3.43.84.52.1-2.0-2.12.11.9-2.0-1.91.9-1.9-2.02.0-1.5
Time in closed arm after self-admin1.61.62.21.1-1.2-1.11.11.3-1.2-1.31.3-1.4-1.51.5-1.0
Time in open arm before self-admin5.76.17.8-2.82.62.6-2.6-2.52.62.5-2.52.42.4-2.41.8
Time in open arm after self-admin3.64.04.4-2.12.02.0-2.0-2.02.02.1-2.11.91.8-1.82.0
Bone: periosteal estimation0.10.10.4-0.20.30.3-0.3-0.30.60.6-0.60.30.3-0.30.2
Bone: periosteal perimeter0.10.10.30.10.0-0.00.0-0.10.60.6-0.60.10.1-0.10.1
Bone: post-yield work1.41.92.7-1.61.51.6-1.7-1.41.21.2-1.21.21.3-1.31.3
Progressive ratio test 1 active lever presses0.00.00.00.1-0.1-0.10.10.1-0.0-0.10.1-0.1-0.10.10.1
Progressive ratio test 1 breakpoint0.10.10.10.3-0.3-0.30.30.3-0.2-0.20.2-0.3-0.30.30.0
Progressive ratio test 1 inactive lever presses2.83.13.4-1.81.81.9-1.9-1.81.81.7-1.71.71.6-1.61.7
Progressive ratio test 2 active lever presses0.00.00.10.0-0.0-0.00.00.10.10.0-0.0-0.1-0.20.2-0.2
Progressive ratio test 2 breakpoint0.00.00.0-0.10.00.1-0.10.00.20.1-0.1-0.1-0.20.2-0.2
Progressive ratio test 2 inactive lever presses0.91.01.5-1.11.01.0-1.0-1.01.21.1-1.10.90.8-0.80.9
Incentive Sensitization - Responses0.00.00.20.0-0.0-0.00.00.10.0-0.10.1-0.2-0.20.2-0.4
Incentive Sensitization - Breakpoint0.00.00.1-0.10.10.1-0.1-0.00.10.0-0.0-0.1-0.10.1-0.3
Sum of active levers in priming session hrs 5-60.30.30.70.8-0.7-0.80.80.5-0.4-0.30.3-0.4-0.30.3-0.4
Progressive ratio0.50.61.1-0.70.60.6-0.6-0.71.00.9-0.90.70.8-0.80.6
Food seeking constrained by brief footshock1.31.62.2-0.91.21.0-1.0-1.31.11.3-1.31.51.5-1.51.4
Seeking ratio, punishment vs. effort0.00.00.1-0.10.20.2-0.2-0.3-0.10.0-0.00.20.2-0.20.3
Retroperitoneal fat weight0.20.81.11.0-0.9-0.90.90.9-0.8-0.90.9-0.8-0.70.7-0.9
Reaction time number correct3.24.65.5-2.42.22.2-2.2-2.22.12.0-2.02.12.1-2.12.3
Reaction time mean minus median0.20.20.40.3-0.4-0.30.30.5-0.6-0.60.6-0.4-0.50.5-0.5
Reaction time mean minus median AUC0.10.20.30.2-0.3-0.20.20.4-0.5-0.60.6-0.4-0.50.5-0.5
Reaction time num false alarms1.01.41.6-1.21.21.1-1.1-1.21.31.2-1.21.11.1-1.11.3
Reaction time num false alarms AUC1.52.02.4-1.41.41.4-1.4-1.41.51.5-1.51.31.3-1.31.5
Reaction time trials correct on left3.24.65.5-2.42.22.2-2.2-2.22.12.0-2.02.12.1-2.12.3
Reaction time trials on left3.24.55.5-2.42.22.2-2.2-2.22.01.9-1.92.12.0-2.02.2
Reaction time mean0.91.21.61.0-1.1-1.01.01.2-1.2-1.21.2-1.0-1.01.0-1.3
Reaction time mean AUC0.60.81.10.7-0.8-0.70.70.9-0.9-1.01.0-0.8-0.80.8-1.0
Median of all reaction times0.40.61.00.7-0.8-0.60.60.9-0.8-0.80.8-0.8-0.70.7-1.0
Reaction time omissions0.91.21.7-1.21.21.3-1.3-1.10.70.7-0.71.21.1-1.11.0
Reaction time false alarm rate0.10.10.3-0.30.30.3-0.3-0.30.50.5-0.50.30.3-0.30.4
Reaction time premature initiation rate0.91.21.6-1.11.01.0-1.0-1.11.21.3-1.31.01.0-1.01.1
Reaction time premature initiations2.83.94.4-2.12.01.9-1.9-2.02.02.0-2.01.91.9-1.92.0
Std. dev. reaction times0.50.60.90.7-0.8-0.70.70.8-0.9-1.01.0-0.7-0.80.8-0.9
Reaction time trials completed3.24.55.5-2.42.22.2-2.2-2.22.01.9-1.92.12.0-2.02.2
Reaction time trials AUC3.44.95.9-2.42.32.3-2.3-2.32.12.0-2.02.22.1-2.12.3
Run reversals in cocaine runway, females1.21.21.81.1-1.1-1.21.21.1-1.3-1.11.1-1.0-1.01.0-1.0
Run reversals in cocaine runway, males0.80.81.2-0.60.70.6-0.6-0.90.91.1-1.11.11.1-1.10.9
Latency to leave start box in cocaine runway0.10.10.30.5-0.4-0.50.50.30.0-0.10.1-0.1-0.30.3-0.2
Latency to leave start box in cocaine runway, F0.10.20.50.6-0.5-0.70.70.3-0.1-0.20.2-0.2-0.20.2-0.2
Latency to leave start box in cocaine runway, M0.10.10.30.5-0.4-0.50.50.3-0.1-0.10.1-0.2-0.30.3-0.3
Std. dev. time between licks in bursts0.40.50.90.3-0.5-0.30.30.8-0.5-0.60.6-1.0-0.90.9-1.0
Total sessions with >9 infusions0.00.00.00.1-0.1-0.10.10.10.10.1-0.1-0.2-0.20.20.1
Short access day 1 total inactive lever presses0.00.00.1-0.30.00.2-0.20.10.0-0.00.0-0.3-0.30.3-0.2
Short access day 10 total inactive lever presses0.40.50.9-0.90.80.9-0.9-0.70.70.6-0.60.50.5-0.50.3
Short access day 1 total infusions0.40.40.6-0.70.60.6-0.6-0.50.80.7-0.70.50.5-0.50.8
Short access day 10 total infusions0.30.40.60.6-0.6-0.60.60.6-0.5-0.50.5-0.8-0.80.8-0.4
Short access total infusions0.10.10.30.3-0.4-0.40.40.4-0.1-0.20.2-0.5-0.60.6-0.1
Short access day 1 locomotion0.40.50.80.6-0.7-0.60.60.8-0.6-0.60.6-0.9-0.90.9-0.3
Short access day 10 total locomotion0.50.60.80.8-0.8-0.80.80.8-0.7-0.70.7-0.9-0.90.9-0.4
Short access total locomotion0.00.00.10.2-0.2-0.20.20.2-0.1-0.00.0-0.3-0.30.30.2
One hour access (0.3 mA shock)0.10.10.4-0.30.30.3-0.3-0.30.60.4-0.40.20.0-0.00.4
Compulsive drug intake0.00.00.1-0.1-0.00.0-0.00.1-0.1-0.30.3-0.2-0.20.2-0.2
One hour access (shock baseline)0.00.00.10.2-0.2-0.20.20.10.10.0-0.0-0.2-0.20.20.0
Social response proportion0.40.50.7-0.70.70.7-0.7-0.60.90.8-0.80.60.5-0.50.7
Social responses0.00.00.00.2-0.1-0.10.10.2-0.10.1-0.1-0.2-0.20.2-0.1
Social time1.21.52.3-1.51.31.5-1.5-1.11.21.2-1.21.11.0-1.01.0
Soleus weight0.00.00.1-0.30.20.3-0.30.00.00.0-0.0-0.2-0.20.2-0.2
Bone: stiffness1.52.42.9-1.51.51.5-1.5-1.51.71.7-1.71.51.5-1.51.4
Tibialis anterior weight0.31.11.3-1.01.11.1-1.1-1.11.11.1-1.11.00.9-0.91.1
Time to tail flick, vehicle, before self-admin0.40.40.6-0.70.70.7-0.7-0.70.50.5-0.50.70.7-0.7-0.1
Time to tail flick, vehicle, after self-admin0.10.10.3-0.1-0.2-0.10.10.3-0.6-0.60.6-0.4-0.40.4-0.1
Time to tail flick, test, before self-admin0.10.10.1-0.00.20.2-0.2-0.30.30.3-0.30.30.2-0.20.1
Time to tail flick, test, after self-admin1.61.72.1-1.51.41.4-1.4-1.41.11.2-1.21.41.4-1.41.0
Delta time to tail flick, vehicle, before/after SA0.00.00.2-0.0-0.1-0.10.10.2-0.2-0.20.2-0.2-0.20.20.4
Delta time to tail flick, test, before/after SA1.11.01.6-1.31.11.1-1.1-1.00.80.8-0.80.91.0-1.01.0
Tibia length0.20.71.1-0.50.70.6-0.6-0.90.70.8-0.81.01.0-1.01.0
Ambulatory time before self-admin0.30.30.70.7-0.6-0.80.80.3-0.5-0.40.4-0.3-0.40.4-0.0
Ambulatory time after self-admin0.00.00.00.1-0.1-0.10.10.10.10.1-0.1-0.1-0.20.2-0.0
Bone: tissue strength0.00.00.10.10.1-0.00.0-0.2-0.00.0-0.00.20.2-0.20.3
Total heroin consumption0.91.01.6-0.80.90.7-0.7-1.01.01.1-1.11.21.3-1.30.8
Bone: trabecular number0.10.10.3-0.50.40.5-0.5-0.30.10.2-0.20.20.3-0.30.2
Bone: trabecular spacing0.10.10.10.4-0.4-0.30.30.3-0.1-0.10.1-0.3-0.30.3-0.3
Bone: trabecular thickness0.10.10.1-0.20.30.3-0.3-0.30.20.2-0.20.40.4-0.40.4
Bone: trabecular tissue density0.20.20.5-0.10.40.1-0.1-0.60.30.3-0.30.70.7-0.70.7
Water consumed over 24 hours3.44.14.9-1.92.01.9-1.9-2.02.22.2-2.22.02.1-2.11.9
Number of responses in last shaping day0.40.40.60.8-0.7-0.70.70.7-0.7-0.60.6-0.6-0.50.5-0.7