Rbm42

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Rbm42 0.03 0.02 1.1e-03 0.02 0.03 0.02 0.03 3.0e-03 1.8e-03 4.5e-03 1.4e-03
2 PL gene expression Rbm42 0.04 0.03 1.0e-02 0.01 0.01 0.01 0.01 1.4e-02 3.3e-02 9.6e-03 7.0e-03
3 NAcc gene expression Rbm42 0.07 0.07 3.1e-04 0.02 0.02 0.03 0.02 7.5e-04 1.2e-03 1.9e-04 4.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.40.61.71.3-0.30.2
Area under the delay curve0.40.40.8-0.10.90.6
BMI with tail0.20.50.9-0.9-0.10.8
BMI without tail0.00.00.0-0.0-0.1-0.2
Body weight1.45.712.83.62.10.2
Weight adjusted by age0.10.10.20.40.30.2
Bone surface0.81.43.01.71.1-0.0
Bone volume0.81.33.51.90.70.1
Breakpoint value in progressive ratio session1.01.01.80.71.31.0
Number of licking bursts1.31.54.0-2.00.2-0.7
Context. condit. distance diff. score0.81.02.0-0.11.01.4
Locomotion velocity, session 11.11.22.2-0.4-1.5-1.1
Locomotion distance, session 10.60.81.50.91.2-0.4
Locomotion velocity, session 22.02.44.9-1.0-1.0-2.2
Locomotion distance, session 21.21.73.0-1.40.6-1.7
Locomotion velocity, session 30.60.82.0-0.5-0.1-1.4
Locomotion distance, session 32.42.66.41.22.50.0
Stereotopy head waving bouts, day 31.31.53.9-0.8-2.0-0.3
Stereotopy head waving duration, day 31.82.25.2-1.2-2.3-0.1
Locomotion velocity, session 70.80.92.30.51.50.2
Locomotion distance, session 70.50.60.70.70.8-0.9
Stereotopy head waving bouts, day 70.60.71.7-1.30.3-0.5
Stereotopy head waving duration, day 71.11.33.4-1.8-0.80.2
Locomotion velocity, session 81.51.85.1-2.3-0.4-0.2
Locomotion distance, session 80.71.01.9-1.01.4-0.4
Degree of sensitization distance0.70.71.6-0.1-1.3-0.7
Degree of sensitization stereotypy0.80.92.1-1.40.6-0.4
Conditioned locomotion0.60.71.2-1.1-0.50.8
Cocaine response after cond. corrected0.80.92.5-0.3-1.60.4
Cocaine response after cond. not corrected1.41.64.50.1-2.1-0.4
Cocaine response before conditioning1.72.03.71.50.1-1.9
Saline control response0.20.20.40.1-0.6-0.4
Bone: connectivity density0.10.20.40.60.0-0.3
Bone: cortical apparent density0.60.82.1-1.5-0.20.4
Bone: cortical area0.40.61.91.40.1-0.1
Bone: cortical porosity2.02.23.5-1.80.0-1.9
Bone: cortical porosity2.32.53.9-2.00.1-1.9
Bone: cortical thickness0.10.20.50.7-0.4-0.2
Bone: cortical thickness0.70.81.9-0.7-1.4-0.3
Bone: cortical tissue density0.70.92.5-1.6-0.30.4
Condit. Reinf. active minus inactive responses0.20.20.4-0.6-0.50.4
Condit. Reinf. active-inactive response ratio1.01.02.1-0.6-1.50.8
Condit. Reinf. active responses1.01.23.2-1.8-0.50.5
Condit. Reinf. inactive responses0.91.13.0-1.70.40.0
Incentive salience index mean0.20.20.6-0.8-0.30.1
Condit. Reinf. lever presses0.10.10.2-0.50.1-0.2
Condit. Reinf. active minus inactive responses0.30.30.91.00.3-0.2
Condit. Reinf. active-inactive response ratio0.10.10.3-0.2-0.50.3
Condit. Reinf. active responses1.31.83.41.81.3-0.5
Condit. Reinf. inactive responses2.53.15.11.82.3-0.9
Condit. Reinf. lever presses2.63.58.62.91.40.1
Condit. Reinf. lever reinforcers received1.62.23.71.91.7-0.5
Conditioned reinforcement - actives1.51.54.4-0.4-0.1-2.1
Conditioned reinforcement - inactives1.31.54.5-0.02.1-0.2
Conditioned locomotion1.11.43.4-1.9-0.0-0.8
Patch foraging indifference point 0 sec0.00.00.1-0.10.3-0.2
Patch foraging indifference point AUC0.30.30.7-0.8-0.5-0.3
Delay disc. indifference point, 0s delay2.12.33.8-0.11.72.0
Delay disc. indifference point, 16s delay0.60.61.1-0.01.10.8
Delay disc. indifference point, 2s delay1.51.73.40.91.81.0
Delay disc. indifference point, 24s delay1.61.53.10.91.80.8
Delay disc. indifference point, 4s delay0.50.50.9-0.70.4-0.9
Delay disc. indifference point, 8s delay0.10.10.30.10.50.1
Indifference point function ln k0.20.30.70.80.4-0.0
Indifference point function log k0.20.30.70.80.4-0.0
Patch foraging total patch changes 0 sec0.10.10.20.10.5-0.3
Patch foraging total patch changes 12 sec0.30.40.7-0.6-0.5-0.8
Patch foraging total patch changes 18 sec0.10.20.4-0.20.6-0.2
Patch foraging total patch changes 24 sec0.91.12.50.91.60.4
Patch foraging total patch changes 6 sec0.10.10.3-0.3-0.1-0.6
Patch foraging time to switch 0 sec0.81.22.2-1.0-1.5-0.6
Patch foraging water rate 0 sec0.30.41.2-1.1-0.1-0.3
Patch foraging water rate 12 sec1.01.51.91.01.4-1.3
Patch foraging water rate 18 sec0.30.30.9-0.4-0.2-0.9
Patch foraging water rate 24 sec1.11.64.7-0.02.2-0.2
Patch foraging water rate 6 sec1.21.84.11.12.0-0.4
Seeking ratio, delayed vs. immediate footshock1.31.53.21.11.80.1
Distance traveled before self-admin0.20.20.50.1-0.1-0.7
Distance traveled after self-admin1.92.13.41.81.6-0.7
Extensor digitorum longus weight0.72.65.2-0.1-1.72.3
Bone: elastic displacement0.50.51.40.0-0.5-1.2
Bone: elastic work0.71.02.11.50.6-0.6
Bone: endosteal estimation0.51.23.01.70.7-0.1
Bone: endosteal perimeter0.51.12.21.51.0-0.1
Epididymis fat weight0.20.51.10.51.0-0.4
Delta time in closed arm before/after self-admin1.81.73.01.70.81.2
Delta time in open arm before/after self-admin0.70.70.8-0.8-0.8-0.9
Diff in mean of infusions in LGA sessions0.50.61.0-1.00.20.8
Delay discount exponential model param0.30.30.8-0.0-0.9-0.3
Extinction: sum of active levers before priming1.91.94.52.10.51.0
Active lever presses in extinction session 61.21.22.81.7-0.9-0.2
Bone: final force0.91.41.91.41.20.9
Bone: final moment1.01.72.81.71.30.8
Food consumed during 24 hour testing period0.70.92.20.61.5-0.2
Glucose0.30.50.8-0.1-0.9-0.8
Heart weight0.40.61.00.30.91.0
Delay discount hyperbolic model param0.30.30.90.0-0.9-0.4
Intermittent access intake day 1-15 change1.61.53.21.81.10.4
Intermittent access intake escalation1.71.73.01.71.30.6
Intermittent access intake escalation 20.70.71.81.30.50.1
Intermitt. access day 1 inactive lever presses1.41.51.81.31.01.3
Intermitt. access day 15 inactive lever presses0.60.71.00.01.01.0
Intermitt. access escalation Index0.40.30.5-0.40.70.6
Intermittent access day 1 total infusions1.61.83.2-1.80.6-1.4
Intermittent access day 15 total infusions1.11.22.9-0.41.7-0.7
Intermittent access terminal intake (last 3 days)1.11.21.8-0.81.3-1.1
Intermittent access total infusions1.41.62.3-1.01.2-1.5
Intermittent access day 1 locomotion1.31.42.2-1.51.1-0.9
Intermittent access day 15 total locomotion1.21.33.1-0.31.8-0.7
Intermittent access total locomotion1.21.32.2-1.50.7-1.2
Intermittent access standard deviation3.03.25.42.12.30.2
Left kidney weight1.44.011.43.40.80.4
Right kidney weight2.36.617.94.21.3-0.1
Cocaine induced anxiety0.50.61.60.60.01.3
Post-drug Anxiety0.80.91.6-0.6-0.81.3
Baseline Anxiety0.80.92.3-1.5-0.4-0.4
Tail length2.06.014.73.81.5-1.0
Length with tail3.914.432.15.73.3-0.4
Length without tail3.37.313.83.72.80.5
Times rat made contact with spout0.30.41.2-0.1-1.10.1
Lifetime Intake1.01.22.2-0.90.7-1.5
Liver weight, left0.40.71.6-0.6-1.30.3
Liver weight, right0.71.12.5-0.5-0.8-1.6
Locomotor activity1.42.23.7-0.6-1.9-1.6
Locomotor testing distance1.11.83.1-0.4-1.5-1.8
Locomotor testing rearing1.21.93.2-1.1-1.0-1.8
Locomotion in novel chamber0.50.61.0-0.8-1.00.3
Locomotion in novel chamber post-restriction0.10.20.3-0.2-0.50.4
Fecal boli incidents, locomotor time 12.02.23.6-1.9-1.6-0.8
Change in fecal boli incidents, locomotor task0.70.61.80.2-1.30.3
Time >=10cm from walls, locomotor time 10.30.30.7-0.2-0.40.8
Bouts of movement, locomotor time 11.01.13.20.31.8-0.1
Total resting periods, locomotor time 10.60.72.00.21.4-0.2
Rest time, locomotor task time 11.11.22.1-1.5-1.10.5
Distance moved, locomotor task time 10.30.30.50.70.60.1
Vertical activity count, locomotor time 11.51.52.31.51.4-0.5
Time >=10cm from walls, locomotor time 21.21.33.0-1.7-0.7-0.6
Bouts of movement, locomotor time 20.40.40.80.00.6-0.9
Total resting periods, locomotor time 20.50.61.6-0.30.2-1.3
Rest time, locomotor task time 20.80.91.2-1.1-0.9-0.8
Distance moved, locomotor task time 20.20.30.80.10.9-0.0
Vertical activity count, locomotor time 21.11.22.71.01.7-0.0
Light reinforcement 10.30.50.9-0.60.4-1.0
Light reinforcement 21.41.94.2-2.0-1.10.5
Bone: marrow area0.61.23.21.80.6-0.2
Bone: maximum diameter0.40.82.21.50.20.4
Bone: maximum force1.42.43.61.91.61.0
Bone: maximum moment1.62.74.52.11.70.8
Mean time between licks in bursts0.10.10.2-0.30.40.3
Mean num. licks in bursts1.01.22.71.6-0.80.6
Cd content in liver0.20.20.30.6-0.1-0.6
Co content in liver0.40.50.9-0.7-0.40.9
Cu content in liver0.50.60.90.80.50.9
Fe content in liver0.10.10.1-0.2-0.30.3
K content in liver0.20.20.2-0.3-0.4-0.5
Mg content in liver0.80.81.3-1.1-1.2-0.0
Mn content in liver1.82.03.4-1.2-1.8-1.1
Na content in liver0.91.01.21.11.0-0.8
Rb content in liver1.51.95.2-0.70.32.3
Se content in liver3.94.78.9-3.0-2.30.1
Sr content in liver1.21.11.3-1.0-1.1-1.0
Zn content in liver0.50.51.3-0.4-0.31.1
Bone: minimum diameter1.22.23.82.01.7-0.1
Time in familiar zone, hab. session 11.11.01.51.1-0.61.2
Time in novel zone, hab. session 11.71.63.0-1.70.2-1.3
Total zone transitions, hab. session 10.20.20.5-0.10.7-0.3
Total locomotion distance, hab. session 11.11.53.90.60.6-2.0
Locomotion velocity, hab. session 11.01.54.10.50.0-2.0
Time in familiar zone, hab. session 20.80.81.21.1-0.80.7
Time in novel zone, hab. session 20.60.61.0-0.90.2-1.0
Total zone transitions, hab. session 21.92.44.6-2.1-0.5-1.5
Total locomotion distance, hab. session 20.71.02.0-0.80.4-1.4
Locomotion velocity, hab. session 20.70.92.0-0.80.2-1.4
Novel to familiar place preference ratio0.40.40.70.20.90.7
Novelty place preference0.30.30.80.10.90.5
Time in novel zone, NPP test0.30.40.8-0.10.90.5
Total zone transitions, NPP test0.20.20.7-0.10.1-0.8
Total locomotion distance, NPP test1.42.03.01.70.7-1.6
Locomotion velocity, NPP test1.42.03.01.70.4-1.7
Intraocular pressure0.20.30.4-0.20.60.7
Delta distance traveled before/after self-admin2.32.54.12.01.70.6
Delta ambulatory time before/after self-admin2.62.95.02.21.90.3
Parametrial fat weight1.01.95.70.2-2.40.1
Pavlov. Cond. lever latency1.21.53.70.80.21.9
Pavlov. Cond. magazine entry latency3.95.014.1-0.8-0.6-3.8
Pavlov. Cond. change in total contacts2.12.35.3-1.00.6-2.3
Pavlov. Cond. index score3.24.110.7-1.1-0.5-3.3
Pavlov. Cond. latency score2.43.18.3-0.9-0.2-2.9
Pavlov. Cond. lever contacts0.91.13.0-0.5-0.0-1.7
Pavlov. Cond. magazine entry number3.74.612.91.00.33.6
Pavlov. Cond. intertrial magazine entries0.60.71.3-0.9-0.11.1
Pavlov. Cond. lever-magazine prob. diff.3.64.511.6-1.3-0.5-3.4
Pavlov. Cond. response bias3.13.710.2-0.6-0.7-3.2
Pavlov. Cond. lever latency2.33.15.6-2.4-1.9-0.2
Pavlov. Cond. magazine entry latency0.80.91.61.31.0-0.3
Pavlov. Cond. change in total contacts4.05.59.13.02.60.7
Pavlov. Cond. index score2.12.75.12.31.8-0.2
Pavlov. Cond. latency score2.02.44.32.11.7-0.3
Pavlov. Cond. lever contacts2.23.05.32.31.90.3
Pavlov. Cond. magazine entry number1.92.34.5-2.1-1.50.2
Pavlov. Cond. intertrial magazine entries0.50.70.8-0.8-0.90.7
Pavlov. Cond. lever-magazine prob. diff.2.02.65.12.31.6-0.3
Pavlov. Cond. response bias2.73.76.12.52.20.3
Time in closed arm before self-admin1.11.23.3-1.8-0.1-0.6
Time in closed arm after self-admin0.50.51.2-0.10.61.1
Time in open arm before self-admin1.61.84.92.20.4-0.5
Time in open arm after self-admin1.21.32.61.20.1-1.6
Bone: periosteal estimation0.71.43.82.00.5-0.0
Bone: periosteal perimeter0.40.71.71.3-0.2-0.5
Bone: post-yield work1.82.54.61.12.11.3
Progressive ratio test 1 active lever presses1.21.33.30.41.8-0.7
Progressive ratio test 1 breakpoint1.11.22.80.61.7-0.6
Progressive ratio test 1 inactive lever presses1.11.23.5-0.11.9-0.1
Progressive ratio test 2 active lever presses1.01.11.6-0.11.3-1.3
Progressive ratio test 2 breakpoint1.01.12.1-0.21.1-1.5
Progressive ratio test 2 inactive lever presses1.92.26.2-0.22.50.7
Incentive Sensitization - Responses0.30.30.5-0.10.5-0.7
Incentive Sensitization - Breakpoint0.20.20.3-0.00.5-0.5
Sum of active levers in priming session hrs 5-60.20.10.20.40.20.5
Progressive ratio0.40.41.1-0.2-0.1-1.1
Food seeking constrained by brief footshock1.11.42.81.70.8-0.8
Seeking ratio, punishment vs. effort0.40.50.70.70.80.4
Retroperitoneal fat weight0.62.03.6-1.5-1.9-0.4
Reaction time number correct0.00.00.10.20.00.3
Reaction time mean minus median0.30.41.21.10.3-0.0
Reaction time mean minus median AUC0.70.92.51.60.40.1
Reaction time num false alarms0.30.41.0-1.0-0.50.1
Reaction time num false alarms AUC0.50.61.4-1.2-0.7-0.0
Reaction time trials correct on left0.00.00.10.20.00.3
Reaction time trials on left0.00.00.10.2-0.00.3
Reaction time mean0.30.40.80.90.3-0.5
Reaction time mean AUC0.30.40.60.70.0-0.8
Median of all reaction times0.20.30.60.50.1-0.8
Reaction time omissions0.20.20.60.2-0.8-0.1
Reaction time false alarm rate0.30.41.1-1.0-0.5-0.1
Reaction time premature initiation rate0.70.92.2-0.40.6-1.5
Reaction time premature initiations0.50.71.6-0.30.7-1.3
Std. dev. reaction times0.70.92.01.40.90.0
Reaction time trials completed0.00.00.10.2-0.00.3
Reaction time trials AUC0.10.10.10.2-0.30.4
Run reversals in cocaine runway, females0.80.81.20.91.10.5
Run reversals in cocaine runway, males1.71.75.0-0.0-2.2-0.2
Latency to leave start box in cocaine runway0.80.91.70.61.30.8
Latency to leave start box in cocaine runway, F0.80.81.40.01.11.2
Latency to leave start box in cocaine runway, M0.20.20.40.60.1-0.3
Std. dev. time between licks in bursts0.91.12.1-0.61.4-1.0
Total sessions with >9 infusions1.11.22.3-1.0-0.5-1.5
Short access day 1 total inactive lever presses1.41.64.1-0.42.00.7
Short access day 10 total inactive lever presses1.61.82.90.81.31.7
Short access day 1 total infusions0.20.20.5-0.30.3-0.7
Short access day 10 total infusions0.30.30.5-0.60.1-0.7
Short access total infusions0.70.81.5-0.9-0.4-1.2
Short access day 1 locomotion0.10.10.2-0.5-0.0-0.4
Short access day 10 total locomotion0.91.12.00.21.4-1.1
Short access total locomotion0.91.01.5-1.2-0.2-1.2
One hour access (0.3 mA shock)2.83.25.10.62.0-2.3
Compulsive drug intake0.00.00.10.1-0.0-0.3
One hour access (shock baseline)1.41.63.2-0.21.3-1.8
Social response proportion2.12.24.11.11.22.0
Social responses0.20.20.50.20.20.7
Social time2.12.73.71.81.91.1
Soleus weight0.10.40.8-0.5-0.90.0
Bone: stiffness1.62.64.41.31.32.1
Tibialis anterior weight0.41.42.50.5-1.61.2
Time to tail flick, vehicle, before self-admin0.40.41.2-1.1-0.2-0.1
Time to tail flick, vehicle, after self-admin0.50.50.9-0.4-0.6-1.0
Time to tail flick, test, before self-admin1.31.23.3-0.41.80.5
Time to tail flick, test, after self-admin0.10.10.2-0.10.4-0.1
Delta time to tail flick, vehicle, before/after SA0.30.30.70.50.0-0.9
Delta time to tail flick, test, before/after SA1.81.63.5-0.4-1.9-1.0
Tibia length2.15.89.63.12.51.3
Ambulatory time before self-admin0.20.20.5-0.1-0.1-0.7
Ambulatory time after self-admin3.74.16.52.52.40.2
Bone: tissue strength3.63.56.61.52.61.3
Total heroin consumption0.30.30.90.40.90.1
Bone: trabecular number0.91.42.51.61.10.7
Bone: trabecular spacing0.60.81.60.2-0.9-1.3
Bone: trabecular thickness0.10.10.20.30.10.4
Bone: trabecular tissue density2.53.58.4-1.1-2.9-1.0
Water consumed over 24 hours0.30.40.60.80.70.2
Number of responses in last shaping day0.70.71.6-0.51.3-0.6