Hub : Genes

Rasa2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA alternative polyA NM_001105724.1 0.07 0.04 3.6e-03 0 0.03 0.01 0.01 2.2e-01 9.7e-03 9.3e-02 6.2e-02
2 BLA alternative polyA XM_039080892.1 0.08 0.05 6.6e-04 0.02 0.05 0.03 0.03 2.5e-02 1.4e-03 1.7e-02 1.1e-02
3 BLA alternative polyA NM_001105724.1 0.07 0.04 3.9e-03 0.01 0.02 0.01 0 8.5e-02 1.8e-02 1.1e-01 1.7e-01
4 BLA alternative polyA XM_039080892.1 0.08 0.05 1.7e-03 0.02 0.05 0.03 0.03 2.2e-02 1.5e-03 6.4e-03 1.3e-02
5 BLA gene expression Rasa2 0.11 0.05 7.1e-05 0.03 0.08 0.06 0.06 1.4e-02 5.5e-05 5.3e-04 5.8e-04
6 OFC mRNA stability Rasa2 0.23 0.11 1.9e-03 0.15 0.11 0.06 0.13 1.9e-04 1.6e-03 1.7e-02 6.8e-04
7 IL mRNA stability Rasa2 0.51 0.16 5.3e-03 -0.01 0.01 0 -0.01 9.0e-01 1.8e-01 3.2e-01 6.3e-01
8 Brain mRNA stability Rasa2 0.11 0.05 1.5e-07 0.07 0.08 0.08 0.08 2.7e-07 3.2e-08 3.5e-08 3.2e-08
9 Adipose gene expression Rasa2 0.2 0.07 0.0e+00 0.13 0.12 0.13 0.13 2.2e-14 3.0e-13 3.1e-14 4.2e-14
10 PL gene expression Rasa2 0.05 0.03 2.1e-04 0.03 0.03 0.02 0.03 4.4e-04 8.3e-04 1.2e-03 6.9e-04
11 pVTA intron excision ratio chr8_97155150_97160286 0.11 0.06 8.4e-03 0.03 0.04 0.03 0.02 2.7e-02 5.2e-03 3.0e-02 3.0e-02
12 Adipose alternative TSS XM_039080891.1 0.04 0.03 3.9e-03 0.02 0.01 0.01 0.01 2.3e-03 1.4e-02 2.8e-02 8.8e-03
13 Adipose alternative TSS XM_039080891.1 0.04 0.03 4.0e-03 0.02 0.01 0.01 0.01 1.5e-03 1.4e-02 2.8e-02 8.3e-03
14 Adipose isoform ratio XM_039080891.1 0.04 0.03 3.4e-03 0.03 0.01 0.01 0.02 5.7e-04 1.3e-02 2.2e-02 5.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.50.81.4-1.21.2-1.11.1-1.20.6-0.6-0.5-1.10.90.6-0.8-0.8-0.8
Area under the delay curve0.50.51.6-0.60.6-0.60.6-0.50.20.10.00.5-0.30.1-1.2-1.2-1.2
BMI with tail3.210.524.24.9-4.94.6-4.44.0-0.72.01.00.8-0.9-3.42.82.82.8
BMI without tail2.44.910.53.0-3.02.5-2.33.2-1.61.22.21.4-1.6-3.21.31.31.3
Body weight5.121.436.36.0-6.05.6-5.45.9-3.13.13.23.6-3.6-3.74.64.64.6
Weight adjusted by age3.64.16.32.4-2.42.2-2.22.5-1.71.71.21.7-1.5-1.82.22.22.2
Bone surface0.30.61.6-1.21.2-1.21.2-0.8-0.50.40.2-0.60.10.5-0.4-0.4-0.4
Bone volume0.20.40.9-0.90.9-0.90.9-0.8-0.1-0.10.0-0.80.30.6-0.3-0.3-0.3
Breakpoint value in progressive ratio session1.71.92.9-1.71.6-1.71.7-1.71.3-0.5-1.1-1.21.20.1-1.4-1.4-1.4
Number of licking bursts0.40.42.3-0.20.2-0.30.20.3-1.31.51.00.2-0.5-0.4-0.2-0.2-0.2
Context. condit. distance diff. score0.50.73.0-0.20.10.2-0.3-0.91.20.0-1.7-1.21.21.10.10.10.1
Locomotion velocity, session 10.50.64.40.7-0.90.6-0.40.30.6-0.2-0.8-0.00.1-2.10.40.40.4
Locomotion distance, session 11.41.83.71.9-1.91.9-1.70.91.00.2-1.0-0.60.7-1.41.31.31.3
Locomotion velocity, session 22.02.412.71.8-2.11.7-1.41.00.70.5-1.10.5-0.1-3.61.21.21.2
Locomotion distance, session 22.63.69.52.6-2.82.5-2.31.80.51.0-0.50.4-0.1-3.11.81.81.8
Locomotion velocity, session 30.60.75.40.6-0.60.5-0.50.4-0.62.30.30.0-0.4-1.3-0.3-0.3-0.3
Locomotion distance, session 30.30.41.60.5-0.50.5-0.50.5-0.51.30.2-0.1-0.3-0.50.80.80.8
Stereotopy head waving bouts, day 34.75.514.61.2-1.20.7-0.92.4-3.53.13.33.8-3.8-2.20.50.50.5
Stereotopy head waving duration, day 33.44.09.71.2-1.20.6-0.72.1-2.62.92.53.1-3.0-2.80.30.30.3
Locomotion velocity, session 71.01.12.81.3-1.21.4-1.30.21.7-0.0-1.3-1.31.2-0.50.10.10.1
Locomotion distance, session 70.30.41.30.6-0.70.6-0.50.30.6-1.1-0.4-0.10.2-0.30.80.80.8
Stereotopy head waving bouts, day 72.12.33.6-1.91.8-1.91.7-1.90.31.6-0.9-1.00.5-0.4-1.9-1.9-1.9
Stereotopy head waving duration, day 72.32.85.8-1.91.9-2.01.7-1.70.11.9-0.4-1.00.50.0-2.4-2.4-2.4
Locomotion velocity, session 81.51.86.80.2-0.30.4-0.2-1.12.6-0.4-2.4-2.12.2-1.0-0.8-0.8-0.8
Locomotion distance, session 80.81.23.11.2-1.21.5-1.50.01.40.5-1.8-1.31.30.10.60.60.6
Degree of sensitization distance0.70.74.30.0-0.00.2-0.0-0.41.2-2.1-0.8-0.81.00.9-0.2-0.2-0.2
Degree of sensitization stereotypy2.83.16.4-1.81.7-1.51.5-2.51.70.7-2.5-2.31.90.2-1.6-1.6-1.6
Conditioned locomotion3.23.86.6-1.91.8-1.82.0-2.22.3-2.6-1.9-2.02.30.3-1.7-1.7-1.7
Cocaine response after cond. corrected0.30.40.80.4-0.30.3-0.40.7-0.60.90.80.7-0.7-0.3-0.6-0.6-0.6
Cocaine response after cond. not corrected0.91.03.60.6-0.50.3-0.31.2-0.80.61.31.9-1.6-1.1-0.6-0.6-0.6
Cocaine response before conditioning0.70.94.30.4-0.50.2-0.11.0-0.7-0.21.22.1-1.7-1.10.10.10.1
Saline control response1.21.63.21.7-1.71.8-1.71.3-0.20.90.1-0.1-0.1-0.61.51.51.5
Bone: connectivity density1.11.83.4-1.81.8-1.81.7-1.80.8-0.7-1.1-1.31.10.6-1.1-1.1-1.1
Bone: cortical apparent density0.91.22.8-1.01.0-1.01.0-1.31.7-1.4-1.4-0.91.00.3-0.9-0.9-0.9
Bone: cortical area1.21.82.71.3-1.31.6-1.60.20.81.5-1.4-1.71.2-0.31.61.61.6
Bone: cortical porosity1.01.03.90.4-0.50.6-0.5-0.61.9-0.4-2.0-1.11.3-0.21.01.01.0
Bone: cortical porosity1.61.86.50.2-0.30.6-0.5-1.02.4-0.8-2.5-1.92.00.50.80.80.8
Bone: cortical thickness0.71.22.41.0-0.91.2-1.30.10.71.5-1.1-1.51.00.11.21.21.2
Bone: cortical thickness0.30.41.1-0.10.0-0.10.3-0.61.0-0.7-1.1-1.11.0-0.70.10.10.1
Bone: cortical tissue density0.91.22.9-1.01.0-0.91.0-1.31.7-1.5-1.3-0.91.00.4-0.9-0.9-0.9
Condit. Reinf. active minus inactive responses0.10.10.20.3-0.30.2-0.20.10.00.10.2-0.30.2-0.3-0.5-0.5-0.5
Condit. Reinf. active-inactive response ratio0.80.82.11.4-1.51.4-1.20.80.40.5-0.3-0.40.5-1.40.50.50.5
Condit. Reinf. active responses0.30.41.1-0.30.3-0.30.4-0.50.5-0.2-0.1-0.80.6-0.0-1.0-1.0-1.0
Condit. Reinf. inactive responses1.11.32.4-1.41.5-1.41.3-1.10.3-0.60.2-0.80.51.1-1.5-1.5-1.5
Incentive salience index mean0.30.41.60.9-1.00.8-0.70.60.00.5-0.10.3-0.2-1.20.00.00.0
Condit. Reinf. lever presses0.91.23.91.5-1.61.5-1.31.10.01.0-0.30.8-0.6-2.00.50.50.5
Condit. Reinf. active minus inactive responses0.30.41.20.00.1-0.20.10.3-0.50.51.10.3-0.5-0.1-0.9-0.9-0.9
Condit. Reinf. active-inactive response ratio1.11.23.71.0-0.80.6-0.71.3-1.20.81.91.5-1.4-0.5-0.8-0.8-0.8
Condit. Reinf. active responses0.40.51.4-0.60.8-0.60.5-0.5-0.00.40.5-0.2-0.20.9-1.2-1.2-1.2
Condit. Reinf. inactive responses0.81.02.2-1.21.2-0.90.8-1.31.0-0.3-1.0-1.20.91.5-0.5-0.5-0.5
Condit. Reinf. lever presses0.70.93.60.6-0.30.7-1.00.7-1.21.61.5-0.1-0.51.9-0.4-0.4-0.4
Condit. Reinf. lever reinforcers received0.30.41.2-0.40.6-0.40.3-0.40.00.50.3-0.2-0.11.1-1.0-1.0-1.0
Conditioned reinforcement - actives0.40.41.80.4-0.40.2-0.30.8-0.90.10.91.4-1.3-0.40.10.10.1
Conditioned reinforcement - inactives0.60.73.20.6-0.50.6-0.70.9-0.90.11.01.8-1.50.40.40.40.4
Conditioned locomotion0.10.20.40.4-0.40.4-0.30.20.2-0.3-0.2-0.00.2-0.50.60.60.6
Patch foraging indifference point 0 sec0.10.20.60.3-0.20.3-0.20.10.1-0.40.3-0.80.70.50.40.40.4
Patch foraging indifference point AUC0.91.04.5-0.30.3-0.10.2-1.01.8-2.1-1.5-0.61.21.1-0.3-0.3-0.3
Delay disc. indifference point, 0s delay1.11.23.2-1.21.2-1.21.0-0.8-0.00.20.40.5-0.30.8-1.8-1.8-1.8
Delay disc. indifference point, 16s delay0.20.21.20.2-0.20.2-0.20.00.11.10.0-0.20.3-0.4-0.5-0.5-0.5
Delay disc. indifference point, 2s delay0.60.71.40.9-0.80.8-0.81.0-0.81.21.01.1-0.8-0.4-0.5-0.5-0.5
Delay disc. indifference point, 24s delay0.60.61.4-0.60.5-0.50.6-0.81.2-1.2-1.10.10.70.1-0.7-0.7-0.7
Delay disc. indifference point, 4s delay1.92.05.7-1.51.6-1.61.6-1.00.00.10.50.0-0.40.3-2.4-2.4-2.4
Delay disc. indifference point, 8s delay0.30.30.6-0.50.5-0.40.3-0.50.3-0.4-0.30.5-0.30.5-0.8-0.8-0.8
Indifference point function ln k1.41.96.70.7-0.70.3-0.41.4-2.62.01.91.3-1.7-1.60.80.80.8
Indifference point function log k1.41.96.70.7-0.70.3-0.41.4-2.62.01.91.3-1.7-1.60.80.80.8
Patch foraging total patch changes 0 sec0.20.30.50.6-0.50.7-0.70.4-0.10.20.3-0.70.50.50.50.50.5
Patch foraging total patch changes 12 sec0.91.24.30.4-0.50.7-0.6-0.62.1-1.7-1.9-0.51.00.70.80.80.8
Patch foraging total patch changes 18 sec0.50.62.00.2-0.20.4-0.2-0.20.9-1.4-0.5-1.41.41.00.30.30.3
Patch foraging total patch changes 24 sec0.50.64.10.00.20.2-0.3-0.41.0-1.2-0.3-0.70.92.0-0.5-0.5-0.5
Patch foraging total patch changes 6 sec0.71.03.8-0.50.5-0.30.4-0.91.4-1.0-0.9-1.91.91.0-0.1-0.1-0.1
Patch foraging time to switch 0 sec2.64.06.9-2.62.4-2.52.6-2.32.0-2.0-1.3-1.21.30.4-2.0-2.0-2.0
Patch foraging water rate 0 sec1.82.94.72.1-2.02.0-2.12.2-2.11.51.81.2-1.40.01.31.31.3
Patch foraging water rate 12 sec2.53.86.12.2-2.12.1-2.22.4-2.52.32.11.2-1.7-0.61.61.61.6
Patch foraging water rate 18 sec3.44.68.22.8-2.72.8-2.92.7-1.91.91.71.4-1.7-0.31.91.91.9
Patch foraging water rate 24 sec1.21.74.71.5-1.31.3-1.51.7-1.92.21.70.4-1.00.20.40.40.4
Patch foraging water rate 6 sec3.04.47.92.5-2.22.4-2.62.7-2.62.82.41.4-1.80.21.31.31.3
Seeking ratio, delayed vs. immediate footshock5.46.216.6-2.01.9-1.61.7-3.13.4-1.9-3.4-3.84.11.2-1.2-1.2-1.2
Distance traveled before self-admin0.90.91.91.3-1.31.4-1.30.8-0.00.0-0.3-0.00.3-0.51.31.31.3
Distance traveled after self-admin0.30.31.50.2-0.30.00.20.3-0.1-1.2-0.00.9-0.7-1.10.20.20.2
Extensor digitorum longus weight1.87.014.63.8-3.73.8-3.82.9-1.22.90.90.3-0.6-1.62.42.42.4
Bone: elastic displacement1.51.73.51.7-1.81.9-1.71.00.5-0.1-0.6-0.40.6-0.51.71.71.7
Bone: elastic work0.91.22.41.3-1.31.4-1.30.70.20.6-0.4-0.60.5-0.51.51.51.5
Bone: endosteal estimation0.20.51.80.9-1.00.8-0.70.6-0.30.40.10.4-0.3-1.30.50.50.5
Bone: endosteal perimeter0.71.42.91.5-1.61.7-1.60.70.20.8-0.7-0.90.7-0.91.41.41.4
Epididymis fat weight0.30.82.11.5-1.41.4-1.41.20.40.30.10.4-0.3-0.60.50.50.5
Delta time in closed arm before/after self-admin1.21.25.2-0.70.7-0.40.2-1.51.70.5-2.3-1.31.21.10.40.40.4
Delta time in open arm before/after self-admin0.30.30.7-0.40.3-0.40.5-0.1-0.6-0.80.2-0.70.6-0.10.70.70.7
Diff in mean of infusions in LGA sessions0.50.51.3-0.90.9-1.00.9-0.7-0.11.1-0.2-0.10.0-0.7-0.6-0.6-0.6
Delay discount exponential model param0.50.51.60.7-0.70.7-0.70.5-0.20.1-0.0-0.40.2-0.11.31.31.3
Extinction: sum of active levers before priming0.90.91.90.2-0.10.5-0.5-0.41.3-0.5-1.4-1.41.31.40.90.90.9
Active lever presses in extinction session 60.40.41.2-0.20.2-0.10.2-0.71.0-1.0-1.1-1.00.30.4-0.2-0.2-0.2
Bone: final force0.20.42.80.4-0.40.3-0.30.4-0.51.70.40.1-0.4-1.00.20.20.2
Bone: final moment0.40.63.70.7-0.60.5-0.60.7-0.81.90.70.2-0.5-1.00.40.40.4
Food consumed during 24 hour testing period0.70.87.0-0.20.5-0.1-0.20.1-1.10.91.1-0.2-0.32.6-0.3-0.3-0.3
Glucose0.50.74.10.3-0.20.5-0.6-0.30.61.0-0.6-2.01.50.9-0.4-0.4-0.4
Heart weight1.11.63.01.5-1.31.6-1.71.2-1.2-0.20.60.8-0.91.61.41.41.4
Delay discount hyperbolic model param0.40.51.50.5-0.50.6-0.50.3-0.0-0.1-0.2-0.60.40.11.21.21.2
Intermittent access intake day 1-15 change0.80.71.80.9-0.80.8-0.91.1-1.00.11.21.3-1.30.50.40.40.4
Intermittent access intake escalation0.40.41.40.7-0.70.7-0.70.8-0.6-0.20.61.2-1.1-0.10.30.30.3
Intermittent access intake escalation 20.10.10.5-0.20.2-0.20.20.1-0.6-0.00.70.3-0.30.2-0.3-0.3-0.3
Intermitt. access day 1 inactive lever presses0.40.42.90.0-0.10.1-0.1-0.41.1-0.7-1.7-0.10.4-0.30.60.60.6
Intermitt. access day 15 inactive lever presses0.20.31.80.1-0.20.1-0.0-0.00.20.4-0.70.8-0.5-1.30.30.30.3
Intermitt. access escalation Index0.60.61.8-0.60.5-0.90.90.0-0.8-0.50.81.3-1.2-0.8-0.4-0.4-0.4
Intermittent access day 1 total infusions0.30.41.40.3-0.40.2-0.10.6-0.6-0.10.31.2-1.1-1.00.40.40.4
Intermittent access day 15 total infusions1.31.53.81.2-1.11.1-1.11.5-1.50.61.21.9-2.0-0.50.70.70.7
Intermittent access terminal intake (last 3 days)1.71.83.61.4-1.31.3-1.31.7-1.70.81.51.8-1.9-0.30.90.90.9
Intermittent access total infusions0.50.51.60.7-0.80.7-0.70.9-0.60.00.51.2-1.1-0.30.40.40.4
Intermittent access day 1 locomotion0.40.42.30.3-0.40.2-0.00.6-0.4-0.30.01.0-0.9-1.50.60.60.6
Intermittent access day 15 total locomotion0.10.10.60.1-0.20.10.00.10.3-0.4-0.30.2-0.0-0.8-0.3-0.3-0.3
Intermittent access total locomotion0.20.21.6-0.1-0.0-0.10.2-0.10.6-1.3-0.60.2-0.0-0.7-0.1-0.1-0.1
Intermittent access standard deviation0.60.63.60.8-0.80.8-0.80.7-0.81.90.50.4-0.5-1.00.10.10.1
Left kidney weight2.88.013.83.7-3.73.6-3.43.1-0.91.60.70.9-1.0-2.23.63.63.6
Right kidney weight3.610.218.03.9-3.93.8-3.73.5-1.91.41.31.9-1.8-1.94.24.24.2
Cocaine induced anxiety0.50.61.3-0.90.8-0.70.6-1.11.1-0.5-1.1-0.60.80.5-0.5-0.5-0.5
Post-drug Anxiety0.20.21.40.1-0.10.4-0.5-0.30.40.4-0.4-0.30.31.20.20.20.2
Baseline Anxiety0.80.82.21.0-0.91.2-1.30.7-0.20.20.2-0.40.11.51.11.11.1
Tail length1.44.213.01.3-1.20.8-0.82.7-3.20.83.62.9-3.2-1.21.01.01.0
Length with tail2.07.314.92.2-2.21.9-1.93.1-3.31.73.03.9-3.8-1.42.72.72.7
Length without tail2.96.410.62.6-2.62.6-2.62.5-2.12.11.22.7-2.5-1.13.33.33.3
Times rat made contact with spout1.51.85.31.3-1.21.5-1.71.1-1.12.30.50.7-1.00.71.51.51.5
Lifetime Intake0.30.41.20.6-0.60.6-0.60.8-0.5-0.20.51.1-0.9-0.30.30.30.3
Liver weight, left0.20.41.10.5-0.40.3-0.40.7-0.81.01.0-0.2-0.2-0.3-0.6-0.6-0.6
Liver weight, right0.61.17.21.2-1.31.0-0.80.90.01.0-0.20.7-0.4-2.70.30.30.3
Locomotor activity1.01.73.31.6-1.51.4-1.41.8-1.1-0.71.81.1-1.20.21.11.11.1
Locomotor testing distance0.30.51.11.0-0.90.9-0.91.0-0.4-0.61.00.5-0.50.40.40.40.4
Locomotor testing rearing0.50.81.61.3-1.21.2-1.21.2-0.50.50.60.7-0.7-0.10.90.90.9
Locomotion in novel chamber2.32.84.5-1.92.0-2.01.9-1.81.0-0.4-0.6-1.61.70.6-2.1-2.1-2.1
Locomotion in novel chamber post-restriction0.50.61.0-0.80.9-0.90.9-0.2-0.5-0.81.00.9-0.70.8-0.7-0.7-0.7
Fecal boli incidents, locomotor time 10.60.61.91.2-1.01.3-1.40.80.10.70.3-0.30.50.80.50.50.5
Change in fecal boli incidents, locomotor task0.40.42.00.6-0.70.4-0.30.6-0.30.2-0.1-0.3-0.4-1.40.80.80.8
Time >=10cm from walls, locomotor time 10.20.20.60.3-0.40.4-0.30.00.4-0.5-0.80.7-0.2-0.70.20.20.2
Bouts of movement, locomotor time 10.40.41.70.2-0.2-0.00.00.6-1.01.31.10.6-0.7-1.0-0.2-0.2-0.2
Total resting periods, locomotor time 10.70.82.70.5-0.50.2-0.30.9-1.21.61.11.0-1.0-1.30.20.20.2
Rest time, locomotor task time 11.51.64.01.7-1.71.8-1.81.00.02.0-0.40.4-0.2-1.01.11.11.1
Distance moved, locomotor task time 10.91.01.7-1.21.2-1.31.3-1.00.7-1.2-0.3-0.90.80.4-1.1-1.1-1.1
Vertical activity count, locomotor time 12.12.23.0-1.61.7-1.41.4-1.61.2-1.0-0.9-1.71.71.7-1.5-1.5-1.5
Time >=10cm from walls, locomotor time 20.80.81.6-0.80.6-0.70.7-1.10.90.0-1.1-0.50.9-0.4-1.2-1.2-1.2
Bouts of movement, locomotor time 20.30.41.00.8-0.80.9-1.00.60.10.9-0.3-0.1-0.2-0.10.40.40.4
Total resting periods, locomotor time 20.60.61.51.1-1.11.2-1.20.9-0.31.1-0.10.1-0.6-0.20.70.70.7
Rest time, locomotor task time 20.10.20.60.5-0.50.6-0.60.30.1-0.40.2-0.3-0.20.80.30.30.3
Distance moved, locomotor task time 21.01.11.9-1.31.2-1.41.4-1.10.50.4-0.6-0.30.9-0.9-1.3-1.3-1.3
Vertical activity count, locomotor time 20.80.91.9-1.21.2-1.11.0-1.41.0-0.2-1.1-1.01.40.7-0.4-0.4-0.4
Light reinforcement 10.61.24.90.8-0.60.8-1.01.1-0.90.91.32.2-1.80.80.10.10.1
Light reinforcement 20.70.93.00.4-0.40.2-0.20.8-0.81.70.71.7-1.4-1.60.10.10.1
Bone: marrow area0.30.62.01.0-1.11.0-0.80.7-0.40.50.10.4-0.3-1.40.70.70.7
Bone: maximum diameter1.63.05.22.0-2.12.3-2.20.51.21.1-1.6-1.81.5-0.82.02.02.0
Bone: maximum force0.20.30.90.3-0.40.3-0.30.1-0.21.0-0.3-0.30.1-0.60.90.90.9
Bone: maximum moment0.30.51.50.6-0.70.6-0.60.4-0.41.2-0.0-0.2-0.1-0.71.11.11.1
Mean time between licks in bursts0.20.31.90.0-0.20.10.0-0.30.70.5-1.1-0.50.3-1.40.40.40.4
Mean num. licks in bursts1.01.23.01.4-1.31.7-1.70.60.50.1-0.60.3-0.11.01.31.31.3
Cd content in liver0.20.21.3-0.30.2-0.20.1-0.30.11.1-0.50.5-0.6-0.10.20.20.2
Co content in liver0.70.83.1-0.20.10.00.1-0.91.8-0.8-1.7-1.01.00.0-0.7-0.7-0.7
Cu content in liver0.70.81.9-0.60.7-0.80.60.0-1.01.31.01.4-1.3-0.1-0.9-0.9-0.9
Fe content in liver0.70.93.10.3-0.10.2-0.40.8-1.71.41.81.1-1.30.8-0.1-0.1-0.1
K content in liver0.40.41.3-0.10.1-0.30.4-0.30.60.0-0.6-0.30.6-1.1-1.0-1.0-1.0
Mg content in liver0.10.10.8-0.0-0.0-0.10.1-0.10.30.5-0.6-0.20.4-0.9-0.2-0.2-0.2
Mn content in liver0.50.61.70.7-0.80.8-0.80.10.80.9-1.3-0.20.4-0.90.70.70.7
Na content in liver0.30.40.9-0.60.5-0.70.8-0.40.2-0.1-0.2-0.90.9-0.6-0.6-0.6-0.6
Rb content in liver0.30.41.30.4-0.30.3-0.40.8-0.90.80.81.0-1.10.20.00.00.0
Se content in liver0.30.41.2-1.00.9-1.11.0-0.3-0.30.20.30.4-0.2-0.2-0.5-0.5-0.5
Sr content in liver0.40.41.2-0.50.5-0.50.5-0.2-0.40.30.50.4-0.4-0.0-1.1-1.1-1.1
Zn content in liver0.10.10.90.2-0.10.3-0.30.2-0.0-0.50.2-0.10.10.9-0.3-0.3-0.3
Bone: minimum diameter0.30.61.40.6-0.60.8-0.80.2-0.01.1-0.2-0.60.2-0.11.21.21.2
Time in familiar zone, hab. session 12.52.36.6-2.32.2-2.62.6-1.3-0.6-1.00.70.7-0.8-0.2-1.3-1.3-1.3
Time in novel zone, hab. session 12.82.77.22.4-2.42.7-2.71.8-0.11.0-0.0-0.20.30.11.61.61.6
Total zone transitions, hab. session 10.91.33.31.4-1.51.5-1.40.21.80.3-1.7-0.81.0-1.3-0.1-0.1-0.1
Total locomotion distance, hab. session 10.70.92.01.4-1.41.4-1.20.61.2-0.4-0.9-0.90.9-1.00.40.40.4
Locomotion velocity, hab. session 10.91.33.61.2-1.31.3-1.10.11.9-0.6-1.6-1.51.5-0.80.10.10.1
Time in familiar zone, hab. session 20.40.44.5-0.20.3-0.0-0.1-0.20.0-1.00.1-0.0-0.12.10.40.40.4
Time in novel zone, hab. session 20.60.63.20.9-1.00.8-0.70.50.30.9-0.3-0.60.6-1.80.30.30.3
Total zone transitions, hab. session 21.01.33.41.8-1.81.9-1.80.81.10.4-1.0-0.10.3-1.10.50.50.5
Total locomotion distance, hab. session 20.60.72.11.4-1.41.4-1.30.80.7-0.6-0.5-0.10.2-0.60.30.30.3
Locomotion velocity, hab. session 20.50.71.81.3-1.41.3-1.20.70.9-0.7-0.70.00.2-0.90.30.30.3
Novel to familiar place preference ratio0.80.84.5-0.10.10.00.1-0.61.0-0.6-0.8-2.11.80.50.50.50.5
Novelty place preference0.60.63.40.2-0.30.4-0.3-0.10.6-0.3-0.4-1.81.40.10.80.80.8
Time in novel zone, NPP test0.70.72.80.6-0.60.7-0.60.20.40.0-0.2-1.71.2-0.11.11.11.1
Total zone transitions, NPP test3.65.212.33.4-3.53.4-3.22.50.50.9-0.30.7-0.5-2.42.12.12.1
Total locomotion distance, NPP test2.23.07.82.8-2.82.6-2.52.1-0.20.70.10.5-0.4-2.01.11.11.1
Locomotion velocity, NPP test1.42.05.52.3-2.32.2-2.11.70.10.3-0.10.3-0.1-1.60.70.70.7
Intraocular pressure1.72.43.61.8-1.81.7-1.71.9-1.81.91.30.9-1.1-1.01.51.51.5
Delta distance traveled before/after self-admin0.70.81.8-1.21.1-1.21.3-0.80.4-1.4-0.2-0.00.2-0.0-0.9-0.9-0.9
Delta ambulatory time before/after self-admin0.70.81.7-1.11.0-1.21.2-0.60.4-1.3-0.10.10.2-0.3-1.1-1.1-1.1
Parametrial fat weight0.30.62.10.00.2-0.1-0.10.5-1.11.21.50.9-1.00.8-0.5-0.5-0.5
Pavlov. Cond. lever latency0.50.72.8-0.70.9-0.70.5-0.1-0.9-0.01.10.7-0.81.7-0.7-0.7-0.7
Pavlov. Cond. magazine entry latency1.01.33.01.5-1.61.5-1.40.80.30.7-0.70.3-0.1-1.71.11.11.1
Pavlov. Cond. change in total contacts0.20.20.40.5-0.60.6-0.50.10.30.1-0.60.00.1-0.60.30.30.3
Pavlov. Cond. index score0.60.82.21.0-1.21.1-0.90.30.90.1-1.1-0.30.6-1.50.70.70.7
Pavlov. Cond. latency score0.81.02.41.3-1.41.3-1.20.60.70.2-0.9-0.20.4-1.51.01.01.0
Pavlov. Cond. lever contacts0.60.72.60.7-0.90.7-0.50.01.1-0.2-1.4-0.50.8-1.60.70.70.7
Pavlov. Cond. magazine entry number0.30.42.2-0.70.8-0.70.5-0.1-0.60.00.8-0.1-0.21.5-0.4-0.4-0.4
Pavlov. Cond. intertrial magazine entries0.91.02.7-1.61.6-1.61.4-0.8-1.00.10.8-0.40.01.4-0.3-0.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.50.72.20.8-1.00.9-0.70.10.9-0.0-1.3-0.30.6-1.50.60.60.6
Pavlov. Cond. response bias0.30.32.90.2-0.40.2-0.0-0.20.60.3-1.00.10.2-1.70.00.00.0
Pavlov. Cond. lever latency0.81.03.0-1.31.0-1.51.6-0.7-0.3-0.5-0.11.1-0.6-1.7-0.7-0.7-0.7
Pavlov. Cond. magazine entry latency1.92.24.21.8-1.81.9-2.01.4-0.51.20.10.7-0.9-0.12.02.02.0
Pavlov. Cond. change in total contacts1.82.56.82.3-2.02.4-2.61.8-0.61.20.80.2-0.51.31.31.31.3
Pavlov. Cond. index score1.01.32.81.5-1.31.6-1.71.2-0.61.00.60.3-0.60.71.31.31.3
Pavlov. Cond. latency score1.21.53.21.5-1.41.7-1.81.3-0.61.00.60.2-0.60.71.51.51.5
Pavlov. Cond. lever contacts0.81.12.71.4-1.21.5-1.60.9-0.10.90.3-0.40.01.21.01.01.0
Pavlov. Cond. magazine entry number0.70.91.7-1.11.1-1.21.3-0.80.2-1.20.1-0.80.80.3-1.1-1.1-1.1
Pavlov. Cond. intertrial magazine entries4.45.710.3-3.23.1-3.23.2-2.71.3-1.8-0.9-2.11.91.0-2.4-2.4-2.4
Pavlov. Cond. lever-magazine prob. diff.1.31.63.31.6-1.51.7-1.81.3-0.51.10.40.5-0.70.51.51.51.5
Pavlov. Cond. response bias0.70.92.71.2-1.11.5-1.60.70.21.0-0.1-0.50.21.30.70.70.7
Time in closed arm before self-admin1.41.66.30.5-0.60.00.21.6-2.3-0.32.51.4-1.0-2.0-0.3-0.3-0.3
Time in closed arm after self-admin0.20.20.80.4-0.40.3-0.20.5-0.70.50.20.4-0.2-0.90.50.50.5
Time in open arm before self-admin0.50.62.5-0.30.4-0.0-0.2-0.71.10.4-0.7-0.60.61.6-0.8-0.8-0.8
Time in open arm after self-admin1.21.32.3-1.41.3-1.11.1-1.51.0-1.3-1.1-1.51.21.3-0.4-0.4-0.4
Bone: periosteal estimation0.61.22.11.4-1.41.5-1.40.50.21.2-0.7-0.70.5-1.11.21.21.2
Bone: periosteal perimeter1.32.13.61.3-1.41.7-1.6-0.01.01.1-1.8-1.91.6-0.11.71.71.7
Bone: post-yield work0.20.20.8-0.50.5-0.50.4-0.4-0.50.90.10.2-0.3-0.1-0.6-0.6-0.6
Progressive ratio test 1 active lever presses0.30.31.70.3-0.40.3-0.10.5-0.1-1.30.30.6-0.7-0.50.50.50.5
Progressive ratio test 1 breakpoint0.30.31.50.5-0.60.5-0.30.50.2-1.20.10.4-0.4-0.60.70.70.7
Progressive ratio test 1 inactive lever presses0.30.31.40.2-0.30.2-0.00.4-0.1-1.20.00.8-0.7-0.50.80.80.8
Progressive ratio test 2 active lever presses0.30.40.80.9-0.80.9-0.90.7-0.40.20.30.7-0.7-0.00.30.30.3
Progressive ratio test 2 breakpoint0.20.20.40.6-0.50.6-0.60.5-0.40.10.40.5-0.50.20.00.00.0
Progressive ratio test 2 inactive lever presses0.50.62.80.2-0.20.1-0.10.7-1.2-0.31.01.7-1.6-0.10.20.20.2
Incentive Sensitization - Responses0.90.94.21.1-0.91.2-1.40.8-0.92.10.30.9-0.90.3-0.1-0.1-0.1
Incentive Sensitization - Breakpoint0.80.93.81.0-0.91.1-1.30.8-0.92.00.30.8-0.90.3-0.1-0.1-0.1
Sum of active levers in priming session hrs 5-60.80.71.30.9-1.01.1-1.10.30.90.2-1.1-0.30.3-0.11.21.21.2
Progressive ratio0.80.92.11.4-1.51.4-1.20.70.40.4-0.3-0.60.8-1.10.70.70.7
Food seeking constrained by brief footshock0.20.31.3-0.1-0.0-0.00.1-0.51.10.3-1.1-0.20.3-0.9-0.2-0.2-0.2
Seeking ratio, punishment vs. effort0.40.51.0-1.01.0-1.00.9-0.70.20.2-0.30.6-0.70.1-0.8-0.8-0.8
Retroperitoneal fat weight1.03.46.92.2-2.11.8-1.82.6-1.91.52.12.3-2.1-1.90.80.80.8
Reaction time number correct0.10.10.30.1-0.10.1-0.20.4-0.50.10.5-0.2-0.10.30.40.40.4
Reaction time mean minus median0.30.41.50.4-0.50.5-0.40.30.2-0.8-0.31.2-0.6-0.20.90.90.9
Reaction time mean minus median AUC0.50.71.30.9-1.01.0-1.00.8-0.40.10.11.2-0.9-0.21.01.01.0
Reaction time num false alarms0.30.41.4-0.80.8-0.80.7-0.6-0.0-0.90.2-0.40.21.2-0.2-0.2-0.2
Reaction time num false alarms AUC0.50.71.5-1.21.2-1.21.2-0.90.2-1.20.0-0.40.11.1-0.4-0.4-0.4
Reaction time trials correct on left0.10.10.30.1-0.10.1-0.20.4-0.50.10.5-0.2-0.10.30.40.40.4
Reaction time trials on left0.10.10.20.1-0.10.1-0.20.4-0.5-0.00.5-0.2-0.10.40.40.40.4
Reaction time mean0.30.42.40.3-0.30.4-0.40.3-0.20.5-0.01.5-1.1-0.10.50.50.5
Reaction time mean AUC0.20.22.1-0.00.00.0-0.10.0-0.10.30.11.5-1.10.10.10.10.1
Median of all reaction times0.20.31.9-0.00.00.0-0.20.0-0.30.80.11.4-1.10.1-0.0-0.0-0.0
Reaction time omissions0.40.52.3-0.40.4-0.30.3-0.61.2-1.5-0.70.10.20.9-0.7-0.7-0.7
Reaction time false alarm rate0.30.40.9-0.90.9-0.90.9-0.70.1-0.80.1-0.0-0.00.6-0.4-0.4-0.4
Reaction time premature initiation rate0.40.51.5-0.60.5-0.80.8-0.2-0.80.70.21.1-0.9-1.2-0.5-0.5-0.5
Reaction time premature initiations0.20.30.9-0.50.4-0.70.6-0.2-0.60.40.10.9-0.7-0.9-0.3-0.3-0.3
Std. dev. reaction times0.10.20.60.1-0.20.2-0.20.00.5-0.6-0.20.8-0.30.40.40.40.4
Reaction time trials completed0.10.10.20.1-0.10.1-0.20.4-0.5-0.00.5-0.2-0.10.40.40.40.4
Reaction time trials AUC0.10.10.30.1-0.00.1-0.10.3-0.5-0.00.5-0.1-0.20.50.40.40.4
Run reversals in cocaine runway, females0.60.63.0-0.20.0-0.50.70.4-0.1-0.50.70.2-0.4-1.7-1.1-1.1-1.1
Run reversals in cocaine runway, males2.32.34.41.2-1.41.2-1.31.2-1.42.10.51.2-1.1-1.52.02.02.0
Latency to leave start box in cocaine runway1.61.73.8-1.91.9-1.91.9-1.50.3-1.2-0.3-0.0-0.10.7-1.3-1.3-1.3
Latency to leave start box in cocaine runway, F0.80.91.7-1.21.2-1.31.3-0.6-0.3-1.30.50.7-0.80.6-0.8-0.8-0.8
Latency to leave start box in cocaine runway, M2.52.44.0-2.01.9-1.91.9-1.91.0-0.2-1.1-0.80.80.0-1.9-1.9-1.9
Std. dev. time between licks in bursts1.92.35.5-1.21.1-1.01.1-1.82.3-0.7-2.1-2.22.3-0.0-1.0-1.0-1.0
Total sessions with >9 infusions0.30.41.00.5-0.50.5-0.40.8-0.6-0.10.81.0-0.8-0.00.50.50.5
Short access day 1 total inactive lever presses1.41.55.8-1.31.1-1.31.5-1.41.6-2.4-1.7-0.20.7-0.7-0.3-0.3-0.3
Short access day 10 total inactive lever presses0.70.73.10.0-0.20.2-0.2-0.61.2-0.3-1.8-1.11.4-0.50.70.70.7
Short access day 1 total infusions0.10.10.6-0.10.1-0.10.20.1-0.0-0.80.10.4-0.20.00.40.40.4
Short access day 10 total infusions0.60.71.31.1-1.01.1-1.11.1-0.50.10.51.0-0.8-0.00.70.70.7
Short access total infusions0.10.11.10.2-0.20.2-0.10.10.3-1.0-0.00.20.10.20.10.10.1
Short access day 1 locomotion1.31.43.5-0.80.9-0.70.7-1.01.8-1.9-1.1-1.01.41.1-1.1-1.1-1.1
Short access day 10 total locomotion0.70.73.2-0.20.0-0.10.2-0.71.6-0.9-1.8-1.01.3-0.80.10.10.1
Short access total locomotion0.30.31.80.2-0.30.3-0.1-0.01.0-1.4-0.8-0.20.5-0.20.10.10.1
One hour access (0.3 mA shock)0.30.41.4-0.10.1-0.10.00.5-1.10.11.20.8-0.90.6-0.1-0.1-0.1
Compulsive drug intake1.41.43.6-1.21.4-1.21.2-0.90.2-1.30.4-0.90.81.9-1.4-1.4-1.4
One hour access (shock baseline)0.80.92.80.5-0.50.4-0.40.9-1.31.20.91.7-1.6-0.90.40.40.4
Social response proportion0.20.20.5-0.70.6-0.70.7-0.50.6-0.3-0.60.6-0.2-0.2-0.0-0.0-0.0
Social responses0.20.21.3-0.00.10.1-0.20.10.10.9-0.01.1-0.70.3-0.2-0.2-0.2
Social time0.20.32.00.00.10.2-0.40.0-0.30.70.10.4-0.31.40.40.40.4
Soleus weight0.92.86.22.5-2.32.3-2.32.1-1.52.41.5-0.0-0.6-1.10.40.40.4
Bone: stiffness0.20.20.7-0.70.6-0.70.6-0.70.10.8-0.6-0.20.0-0.4-0.1-0.1-0.1
Tibialis anterior weight1.24.17.82.8-2.72.7-2.62.6-1.71.21.90.1-0.7-0.82.12.12.1
Time to tail flick, vehicle, before self-admin0.50.52.10.5-0.30.5-0.70.7-1.41.00.90.7-0.51.00.10.10.1
Time to tail flick, vehicle, after self-admin1.82.04.91.2-1.41.1-1.01.5-0.80.00.51.9-2.2-1.71.61.61.6
Time to tail flick, test, before self-admin0.80.82.3-0.60.8-0.70.6-0.4-0.60.60.50.7-0.70.5-1.5-1.5-1.5
Time to tail flick, test, after self-admin4.04.211.52.0-1.91.9-2.02.6-3.42.32.71.6-1.8-0.31.51.51.5
Delta time to tail flick, vehicle, before/after SA0.70.73.70.4-0.60.3-0.00.30.6-1.1-0.50.7-1.0-1.90.80.80.8
Delta time to tail flick, test, before/after SA3.12.86.01.7-1.61.6-1.72.2-2.51.42.20.6-1.00.01.71.71.7
Tibia length1.74.910.31.8-1.81.2-1.12.8-3.21.93.22.8-3.1-2.80.90.90.9
Ambulatory time before self-admin0.70.71.61.2-1.21.3-1.20.70.10.3-0.2-0.10.3-0.51.01.01.0
Ambulatory time after self-admin0.30.32.0-0.1-0.1-0.20.40.00.4-1.4-0.20.50.1-1.10.00.00.0
Bone: tissue strength2.42.36.01.1-0.80.9-1.21.8-2.21.82.32.4-2.40.70.20.20.2
Total heroin consumption2.52.96.91.3-1.41.3-1.51.6-1.82.21.12.1-2.6-0.71.81.81.8
Bone: trabecular number1.32.13.7-1.91.8-1.81.9-1.91.1-0.9-1.2-1.11.00.2-1.4-1.4-1.4
Bone: trabecular spacing0.20.22.00.4-0.10.4-0.50.20.1-0.00.4-0.30.11.4-0.1-0.1-0.1
Bone: trabecular thickness0.20.21.20.4-0.50.2-0.00.5-0.2-0.70.50.3-0.4-1.10.10.10.1
Bone: trabecular tissue density1.01.43.61.3-1.41.4-1.21.00.3-0.6-0.0-0.20.2-0.51.91.91.9
Water consumed over 24 hours0.50.63.20.3-0.20.3-0.50.7-1.31.81.20.1-0.70.80.40.40.4
Number of responses in last shaping day0.30.40.80.4-0.40.2-0.10.7-0.4-0.50.60.9-0.6-0.60.80.80.8