Hub : Genes

Rara

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC isoform ratio NM_031528.2 0.08 0.06 6.1e-03 0.03 0.03 0 0.02 2.3e-02 1.5e-02 2.2e-01 4.5e-02
2 IC alternative TSS NM_031528.2 0.1 0.07 1.5e-03 0.02 0.05 0.03 0.05 4.1e-02 2.6e-03 2.3e-02 4.8e-03
3 IC mRNA stability Rara 0.13 0.08 6.1e-05 0.06 0.08 0.07 0.08 2.0e-03 2.9e-04 9.2e-04 4.2e-04
4 IC gene expression Rara 0.29 0.18 4.8e-06 0.15 0.14 0.13 0.14 5.7e-07 1.3e-06 5.5e-06 1.7e-06
5 Liver mRNA stability Rara 0.09 0.05 2.9e-05 0.04 0.04 0.03 0.04 3.5e-05 2.4e-05 2.7e-04 8.6e-05
6 Liver intron excision ratio chr10_84389819_84398920 0.05 0.04 7.4e-05 0.05 0.03 0.03 0.04 1.7e-06 2.9e-04 1.4e-04 6.2e-05
7 Liver intron excision ratio chr10_84389819_84401621 0.06 0.04 5.5e-06 0.05 0.03 0.04 0.05 3.8e-06 1.1e-04 1.1e-05 4.6e-06
8 Liver alternative TSS NM_031528.2 0.02 0.02 3.0e-03 0.02 0.01 0.02 0.01 3.2e-03 3.6e-02 5.9e-03 9.7e-03
9 Liver gene expression Rara 0.03 0.03 8.6e-04 0.01 0.01 0.01 0.01 1.2e-02 1.3e-02 1.7e-02 9.0e-03
10 Brain mRNA stability Rara 0.03 0.02 3.1e-03 0.01 0.02 0.02 0.01 2.2e-02 3.2e-03 9.1e-03 1.2e-02
11 OFC gene expression Rara 0.21 0.12 4.3e-04 0.1 0.14 0.12 0.13 2.4e-03 3.8e-04 9.4e-04 4.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density2.33.95.01.81.8-1.81.9-1.92.0-2.2-2.21.9-2.02.2
Area under the delay curve0.40.40.80.60.6-0.70.9-0.30.5-0.7-0.50.6-0.90.8
BMI with tail2.48.311.2-3.3-3.33.3-2.82.9-2.72.72.7-2.62.8-2.4
BMI without tail1.23.75.4-2.3-2.32.3-1.91.9-1.51.91.8-1.81.9-1.5
Body weight6.427.835.2-5.9-5.95.9-5.35.4-5.15.25.1-4.94.7-4.3
Weight adjusted by age0.20.31.1-0.6-0.60.5-0.60.6-1.10.30.0-0.1-0.20.4
Bone surface0.00.10.2-0.1-0.10.10.4-0.30.4-0.3-0.30.2-0.10.5
Bone volume0.20.30.60.10.1-0.10.6-0.60.6-0.7-0.70.5-0.40.8
Breakpoint value in progressive ratio session0.10.10.5-0.1-0.10.0-0.70.1-0.6-0.1-0.10.1-0.20.2
Number of licking bursts0.10.20.50.20.2-0.10.5-0.70.3-0.4-0.40.6-0.10.5
Context. condit. distance diff. score1.41.73.1-1.1-1.11.0-1.11.6-1.31.51.4-1.80.9-1.4
Locomotion velocity, session 10.50.60.9-1.0-1.00.9-0.70.8-0.80.60.6-0.70.6-0.5
Locomotion distance, session 12.22.84.0-2.0-2.02.0-1.51.7-1.71.51.4-1.71.5-1.2
Locomotion velocity, session 20.10.20.3-0.4-0.40.4-0.60.5-0.30.40.4-0.30.2-0.3
Locomotion distance, session 20.10.10.4-0.6-0.60.6-0.20.2-0.30.00.1-0.10.20.1
Locomotion velocity, session 30.00.00.10.30.3-0.3-0.1-0.10.10.10.10.1-0.30.2
Locomotion distance, session 30.20.20.5-0.5-0.50.5-0.60.4-0.70.50.5-0.50.4-0.4
Stereotopy head waving bouts, day 32.42.93.51.81.8-1.81.9-1.41.8-1.5-1.41.6-1.81.7
Stereotopy head waving duration, day 30.20.20.60.30.3-0.40.7-0.10.7-0.4-0.20.3-0.60.5
Locomotion velocity, session 71.11.21.6-1.2-1.21.3-1.00.8-1.21.21.1-0.91.2-0.9
Locomotion distance, session 70.50.61.3-0.7-0.70.8-0.50.3-0.90.70.6-0.71.1-1.0
Stereotopy head waving bouts, day 70.70.71.40.70.7-0.81.0-0.60.8-0.7-0.80.8-1.21.2
Stereotopy head waving duration, day 70.30.41.30.40.4-0.50.4-0.10.5-0.4-0.50.6-1.11.0
Locomotion velocity, session 87.99.511.1-3.2-3.13.1-3.03.3-3.13.03.1-3.32.8-3.0
Locomotion distance, session 81.42.02.7-1.6-1.61.5-1.31.6-1.41.31.3-1.71.1-1.1
Degree of sensitization distance1.11.12.0-1.0-1.01.0-0.90.8-0.81.01.0-1.21.4-1.4
Degree of sensitization stereotypy0.70.71.40.60.7-0.71.0-0.60.8-0.7-0.80.8-1.11.2
Conditioned locomotion0.20.30.60.60.6-0.60.3-0.30.4-0.5-0.40.5-0.80.6
Cocaine response after cond. corrected0.60.72.10.30.4-0.51.4-0.50.7-0.9-0.80.9-1.01.3
Cocaine response after cond. not corrected0.70.92.80.40.4-0.51.7-0.60.6-1.0-0.90.9-1.01.4
Cocaine response before conditioning0.00.00.20.20.2-0.20.5-0.2-0.1-0.2-0.2-0.0-0.10.0
Saline control response0.60.81.3-1.1-1.11.0-0.31.0-0.80.90.9-0.90.7-0.5
Bone: connectivity density3.45.46.42.22.2-2.22.2-2.32.3-2.5-2.52.3-2.32.4
Bone: cortical apparent density5.37.39.93.13.1-3.12.7-2.82.4-2.6-2.72.5-2.42.0
Bone: cortical area0.10.10.30.30.3-0.30.5-0.40.3-0.3-0.30.3-0.40.4
Bone: cortical porosity0.40.41.00.20.3-0.41.0-0.40.7-0.7-0.70.6-0.81.0
Bone: cortical porosity0.10.20.6-0.2-0.20.10.80.00.3-0.3-0.30.2-0.50.7
Bone: cortical thickness1.01.62.31.41.4-1.51.3-1.10.9-1.2-1.21.1-1.51.3
Bone: cortical thickness5.05.98.72.42.5-2.62.1-2.02.2-2.4-2.42.3-3.02.7
Bone: cortical tissue density5.47.39.93.23.1-3.12.7-2.82.4-2.7-2.72.5-2.42.0
Condit. Reinf. active minus inactive responses1.21.41.91.31.4-1.40.9-1.10.9-1.1-1.11.2-1.21.0
Condit. Reinf. active-inactive response ratio1.51.62.51.51.6-1.61.0-1.20.8-1.2-1.11.4-1.31.0
Condit. Reinf. active responses1.01.31.81.31.3-1.40.9-1.10.9-1.1-1.11.2-1.11.0
Condit. Reinf. inactive responses0.10.10.10.20.2-0.20.2-0.20.3-0.3-0.30.3-0.20.3
Incentive salience index mean2.22.73.31.81.8-1.81.5-1.81.6-1.6-1.51.7-1.51.4
Condit. Reinf. lever presses1.31.92.91.41.4-1.41.4-1.71.5-1.3-1.31.3-1.01.2
Condit. Reinf. active minus inactive responses1.11.42.11.21.2-1.10.8-1.41.0-1.3-1.31.3-1.01.1
Condit. Reinf. active-inactive response ratio1.01.21.71.11.0-0.90.9-1.31.1-1.3-1.21.2-0.81.1
Condit. Reinf. active responses1.62.33.11.51.5-1.41.2-1.81.4-1.6-1.61.7-1.31.6
Condit. Reinf. inactive responses1.51.92.41.31.3-1.31.5-1.51.3-1.4-1.41.5-1.31.5
Condit. Reinf. lever presses0.10.20.30.40.5-0.40.4-0.40.2-0.3-0.30.5-0.50.5
Condit. Reinf. lever reinforcers received1.82.63.31.61.6-1.61.3-1.81.4-1.7-1.61.8-1.51.6
Conditioned reinforcement - actives0.10.10.50.40.4-0.30.7-0.5-0.2-0.2-0.10.40.1-0.1
Conditioned reinforcement - inactives0.20.30.50.60.6-0.50.4-0.60.5-0.7-0.60.50.0-0.1
Conditioned locomotion0.50.71.61.00.9-0.80.9-1.30.4-0.7-0.71.0-0.40.6
Patch foraging indifference point 0 sec1.73.14.52.12.0-1.92.1-2.11.6-1.6-1.61.6-1.21.1
Patch foraging indifference point AUC0.00.00.1-0.3-0.30.20.30.3-0.00.10.1-0.2-0.10.1
Delay disc. indifference point, 0s delay1.82.02.21.51.4-1.41.5-1.41.4-1.4-1.31.3-1.41.4
Delay disc. indifference point, 16s delay0.30.31.10.40.5-0.70.60.20.4-0.5-0.30.2-1.10.6
Delay disc. indifference point, 2s delay1.01.22.61.00.9-0.91.6-1.20.7-1.1-1.11.1-0.91.2
Delay disc. indifference point, 24s delay0.10.10.2-0.2-0.20.20.10.4-0.10.40.4-0.30.3-0.5
Delay disc. indifference point, 4s delay1.21.22.40.91.0-1.10.9-0.70.8-1.1-1.01.2-1.51.5
Delay disc. indifference point, 8s delay0.10.20.40.40.3-0.30.6-0.40.6-0.4-0.20.4-0.30.3
Indifference point function ln k0.00.00.10.10.1-0.20.10.2-0.20.40.3-0.1-0.1-0.2
Indifference point function log k0.00.00.10.10.1-0.20.10.2-0.20.40.3-0.1-0.1-0.2
Patch foraging total patch changes 0 sec1.12.03.41.71.6-1.51.8-1.81.3-1.3-1.21.2-0.80.8
Patch foraging total patch changes 12 sec4.96.38.12.62.5-2.42.6-2.82.4-2.6-2.72.4-2.22.4
Patch foraging total patch changes 18 sec0.30.51.00.80.7-0.60.9-1.00.6-0.6-0.60.6-0.30.4
Patch foraging total patch changes 24 sec0.71.31.61.11.1-1.11.3-1.10.6-1.3-1.11.1-1.31.2
Patch foraging total patch changes 6 sec1.62.53.41.71.7-1.61.8-1.81.7-1.5-1.51.4-1.21.2
Patch foraging time to switch 0 sec0.10.10.20.30.3-0.30.1-0.30.2-0.4-0.50.4-0.30.4
Patch foraging water rate 0 sec0.10.20.30.50.5-0.50.3-0.50.5-0.3-0.30.4-0.30.2
Patch foraging water rate 12 sec0.00.10.4-0.1-0.00.0-0.70.2-0.60.30.10.1-0.1-0.0
Patch foraging water rate 18 sec0.50.81.60.70.7-0.70.8-0.80.7-0.8-1.01.0-1.21.3
Patch foraging water rate 24 sec0.50.81.60.90.9-0.90.7-1.01.3-0.7-0.80.8-0.70.7
Patch foraging water rate 6 sec1.82.73.21.71.7-1.71.3-1.61.6-1.4-1.61.7-1.81.8
Seeking ratio, delayed vs. immediate footshock0.10.10.30.30.4-0.4-0.40.1-0.6-0.00.1-0.1-0.1-0.3
Distance traveled before self-admin0.10.10.40.10.1-0.2-0.1-0.10.3-0.3-0.30.5-0.50.6
Distance traveled after self-admin0.40.50.9-0.8-0.80.8-1.00.9-0.30.70.8-0.60.5-0.5
Extensor digitorum longus weight9.838.741.2-6.2-6.16.2-6.26.0-6.46.46.4-6.16.2-6.3
Bone: elastic displacement0.10.10.30.10.00.10.2-0.2-0.20.10.1-0.20.5-0.5
Bone: elastic work0.10.10.30.10.1-0.20.4-0.20.2-0.3-0.30.2-0.40.5
Bone: endosteal estimation2.14.66.7-2.5-2.62.6-1.71.9-1.72.12.1-2.02.3-1.8
Bone: endosteal perimeter1.32.73.9-1.7-1.81.9-1.61.3-1.21.71.6-1.62.0-1.7
Epididymis fat weight0.10.40.8-0.9-0.90.8-0.60.7-0.70.50.5-0.50.4-0.2
Delta time in closed arm before/after self-admin5.04.65.9-2.3-2.32.2-2.42.4-2.12.01.9-2.31.8-1.8
Delta time in open arm before/after self-admin0.00.00.1-0.1-0.1-0.0-0.00.30.0-0.10.1-0.0-0.1-0.0
Diff in mean of infusions in LGA sessions0.10.10.30.10.1-0.1-0.6-0.1-0.2-0.3-0.30.2-0.40.4
Delay discount exponential model param0.20.20.6-0.4-0.40.5-0.70.1-0.40.40.3-0.40.8-0.6
Extinction: sum of active levers before priming1.61.72.4-1.5-1.51.5-0.91.4-1.31.31.2-1.31.2-1.1
Active lever presses in extinction session 60.60.62.80.00.0-0.21.0-0.20.7-0.5-0.60.7-1.31.7
Bone: final force0.50.81.80.50.4-0.51.3-0.80.9-0.8-0.80.9-0.91.3
Bone: final moment0.30.51.40.30.2-0.31.2-0.60.8-0.6-0.70.7-0.71.1
Food consumed during 24 hour testing period0.71.01.2-1.0-1.01.1-1.00.9-0.81.11.0-1.01.0-0.9
Glucose0.10.21.0-0.4-0.40.41.00.1-0.10.30.3-0.30.00.3
Heart weight3.65.56.2-2.4-2.42.4-2.12.2-2.52.42.4-2.52.4-2.3
Delay discount hyperbolic model param0.20.20.5-0.4-0.40.5-0.70.1-0.30.40.3-0.40.7-0.6
Intermittent access intake day 1-15 change0.10.20.50.30.3-0.4-0.5-0.00.5-0.5-0.40.4-0.70.6
Intermittent access intake escalation0.10.20.40.20.3-0.3-0.50.10.4-0.5-0.30.3-0.70.5
Intermittent access intake escalation 20.20.20.9-0.4-0.40.4-0.90.50.10.10.3-0.40.3-0.3
Intermitt. access day 1 inactive lever presses0.72.64.51.41.5-1.60.9-1.11.7-1.7-1.81.6-2.11.9
Intermitt. access day 15 inactive lever presses1.32.63.51.81.8-1.81.1-1.61.9-1.6-1.51.7-1.41.2
Intermitt. access escalation Index1.72.43.9-1.8-1.71.6-2.02.0-1.41.61.4-1.50.7-0.7
Intermittent access day 1 total infusions0.00.00.10.10.1-0.10.3-0.0-0.1-0.2-0.10.1-0.0-0.1
Intermittent access day 15 total infusions0.00.10.30.00.1-0.2-0.20.40.1-0.3-0.10.1-0.50.3
Intermittent access terminal intake (last 3 days)0.20.20.50.40.4-0.50.3-0.00.7-0.6-0.50.4-0.60.4
Intermittent access total infusions0.00.00.10.10.1-0.20.10.30.1-0.3-0.20.1-0.30.1
Intermittent access day 1 locomotion0.00.10.30.20.2-0.20.5-0.3-0.2-0.1-0.00.10.2-0.2
Intermittent access day 15 total locomotion0.20.30.80.60.5-0.50.9-0.80.2-0.6-0.50.5-0.10.3
Intermittent access total locomotion0.70.91.71.01.0-1.01.3-1.00.7-1.0-0.90.9-0.70.6
Intermittent access standard deviation1.12.43.31.61.6-1.60.8-1.31.8-1.8-1.81.5-1.51.3
Left kidney weight0.41.84.5-1.5-1.41.3-2.11.7-0.81.41.2-1.10.5-0.6
Right kidney weight0.00.20.6-0.5-0.40.3-0.80.40.5-0.1-0.30.1-0.50.6
Cocaine induced anxiety2.43.55.1-2.1-2.12.0-2.12.3-1.61.91.8-1.81.3-1.3
Post-drug Anxiety0.70.71.4-1.0-0.90.9-0.91.2-0.60.90.8-0.80.6-0.7
Baseline Anxiety1.82.14.51.61.5-1.52.1-1.71.1-1.4-1.31.5-0.80.9
Tail length0.41.62.2-1.3-1.31.2-1.51.5-1.31.41.3-1.20.9-1.0
Length with tail2.29.414.0-3.3-3.33.2-3.73.3-3.23.02.9-2.82.4-2.4
Length without tail2.89.110.9-3.2-3.23.3-3.32.8-3.23.02.9-2.82.8-2.6
Times rat made contact with spout0.70.81.40.90.8-0.81.0-1.21.2-0.9-1.00.9-0.40.6
Lifetime Intake0.10.20.40.30.4-0.50.20.00.3-0.6-0.40.4-0.60.4
Liver weight, left0.20.40.7-0.8-0.80.8-0.40.5-0.60.50.5-0.50.7-0.5
Liver weight, right0.40.71.80.40.4-0.61.20.01.0-0.6-0.60.4-1.41.2
Locomotor activity0.50.81.50.60.6-0.61.1-0.90.8-1.0-1.11.0-0.91.2
Locomotor testing distance2.03.64.01.81.8-1.82.0-1.92.0-1.9-2.01.9-1.92.0
Locomotor testing rearing4.99.811.93.33.3-3.33.2-3.03.4-2.9-2.93.0-3.12.9
Locomotion in novel chamber4.35.57.82.42.4-2.52.8-2.31.9-2.2-2.22.4-2.42.4
Locomotion in novel chamber post-restriction0.30.50.90.60.6-0.50.6-0.90.8-0.7-0.60.9-0.40.8
Fecal boli incidents, locomotor time 10.30.41.1-0.5-0.50.6-0.10.3-0.90.60.6-0.51.0-0.9
Change in fecal boli incidents, locomotor task0.10.10.20.10.1-0.20.3-0.1-0.0-0.2-0.30.0-0.50.4
Time >=10cm from walls, locomotor time 10.20.20.60.60.6-0.60.7-0.4-0.4-0.1-0.20.3-0.30.1
Bouts of movement, locomotor time 10.30.30.9-0.7-0.70.7-1.00.7-0.40.40.4-0.30.4-0.3
Total resting periods, locomotor time 10.80.91.3-1.1-1.11.1-1.11.0-0.80.60.6-0.70.9-0.7
Rest time, locomotor task time 10.00.00.10.0-0.00.1-0.2-0.40.2-0.2-0.00.10.3-0.1
Distance moved, locomotor task time 10.10.10.3-0.2-0.1-0.10.50.5-0.60.20.2-0.2-0.40.3
Vertical activity count, locomotor time 10.20.42.5-0.6-0.60.5-0.10.6-1.60.50.5-0.50.3-0.4
Time >=10cm from walls, locomotor time 20.81.12.41.01.0-1.01.6-1.20.0-0.8-1.11.2-1.01.1
Bouts of movement, locomotor time 20.40.61.10.80.8-0.80.2-0.71.0-0.6-0.70.9-0.90.8
Total resting periods, locomotor time 20.20.40.60.60.7-0.7-0.1-0.50.8-0.4-0.50.7-0.80.6
Rest time, locomotor task time 20.70.81.6-0.9-0.90.9-1.00.8-1.20.80.8-0.70.9-0.8
Distance moved, locomotor task time 20.30.30.6-0.7-0.70.50.50.7-0.70.60.7-0.60.2-0.1
Vertical activity count, locomotor time 20.50.62.1-0.8-0.80.7-0.20.8-1.50.70.8-0.70.6-0.7
Light reinforcement 12.15.15.92.32.3-2.21.8-2.32.3-2.4-2.42.2-2.22.3
Light reinforcement 20.40.61.20.40.4-0.50.9-0.61.1-0.9-1.00.5-0.91.1
Bone: marrow area2.04.36.3-2.4-2.52.5-1.71.9-1.62.12.0-2.02.2-1.8
Bone: maximum diameter0.00.00.10.10.1-0.10.1-0.30.3-0.2-0.20.3-0.20.3
Bone: maximum force0.10.10.3-0.5-0.60.50.10.3-0.10.30.3-0.20.10.2
Bone: maximum moment0.10.20.5-0.7-0.70.7-0.00.5-0.20.50.5-0.50.3-0.0
Mean time between licks in bursts0.92.34.1-1.4-1.51.6-1.40.9-1.21.51.6-1.42.0-1.8
Mean num. licks in bursts0.10.10.30.40.4-0.50.3-0.10.5-0.2-0.30.1-0.30.1
Cd content in liver1.61.82.4-1.2-1.31.3-1.41.2-1.21.31.4-1.31.5-1.5
Co content in liver1.92.23.4-1.3-1.31.3-1.71.5-1.41.41.4-1.61.6-1.9
Cu content in liver0.10.10.20.40.4-0.5-0.1-0.0-0.1-0.2-0.20.2-0.40.2
Fe content in liver1.72.13.0-1.7-1.71.7-1.11.6-1.31.41.4-1.51.3-1.1
K content in liver1.41.33.41.01.1-1.20.9-0.50.9-1.1-1.01.1-1.81.6
Mg content in liver1.01.02.51.11.1-1.30.8-0.40.8-0.8-0.80.8-1.61.1
Mn content in liver1.51.72.41.51.5-1.61.1-1.21.0-1.2-1.21.2-1.41.1
Na content in liver0.40.41.60.00.1-0.20.6-0.20.5-0.7-0.80.7-1.01.3
Rb content in liver1.61.83.71.51.4-1.41.9-1.41.5-1.3-1.21.1-1.00.9
Se content in liver8.19.611.73.23.2-3.32.8-2.73.0-3.0-3.13.1-3.43.2
Sr content in liver0.10.10.60.20.2-0.2-0.80.1-0.50.20.2-0.20.1-0.4
Zn content in liver3.74.15.22.12.1-2.21.7-1.72.1-1.9-1.92.0-2.32.1
Bone: minimum diameter0.50.91.4-1.2-1.21.1-0.41.0-0.81.11.1-1.00.9-0.7
Time in familiar zone, hab. session 10.10.10.6-0.2-0.20.10.4-0.10.5-0.1-0.10.3-0.40.8
Time in novel zone, hab. session 10.60.61.41.21.2-1.10.9-0.80.3-0.6-0.60.6-0.40.1
Total zone transitions, hab. session 11.92.73.1-1.6-1.61.6-1.61.7-1.71.71.7-1.81.4-1.5
Total locomotion distance, hab. session 10.00.00.1-0.00.0-0.1-0.20.3-0.30.10.1-0.2-0.1-0.0
Locomotion velocity, hab. session 10.20.31.0-0.5-0.50.4-1.00.8-0.80.30.4-0.60.1-0.3
Time in familiar zone, hab. session 20.60.61.30.40.4-0.60.9-0.30.7-0.8-1.00.7-1.11.1
Time in novel zone, hab. session 20.20.20.50.70.7-0.60.1-0.70.2-0.3-0.20.5-0.10.0
Total zone transitions, hab. session 21.21.52.0-1.3-1.31.3-0.71.1-1.41.21.1-1.31.4-1.3
Total locomotion distance, hab. session 20.30.40.6-0.7-0.70.7-0.40.5-0.80.30.3-0.60.8-0.6
Locomotion velocity, hab. session 20.50.71.0-0.9-0.90.9-0.70.7-1.00.50.6-0.80.9-0.8
Novel to familiar place preference ratio1.01.02.8-0.9-0.80.8-1.71.3-1.01.21.0-0.80.4-0.7
Novelty place preference0.80.92.6-0.8-0.70.6-1.61.2-0.91.11.0-0.80.3-0.7
Time in novel zone, NPP test0.30.41.4-0.4-0.30.3-1.20.8-0.70.70.6-0.4-0.0-0.3
Total zone transitions, NPP test0.60.91.7-1.1-1.21.2-0.20.6-1.00.70.6-1.11.3-0.9
Total locomotion distance, NPP test0.10.10.3-0.4-0.40.50.4-0.0-0.2-0.0-0.0-0.40.6-0.2
Locomotion velocity, NPP test0.40.61.2-0.8-0.90.9-0.30.5-0.40.50.5-1.01.1-0.8
Intraocular pressure3.44.97.6-2.1-2.22.2-1.72.0-1.82.32.2-2.22.8-2.7
Delta distance traveled before/after self-admin1.41.51.9-1.2-1.21.2-1.21.4-1.21.21.3-1.21.1-1.2
Delta ambulatory time before/after self-admin1.51.82.3-1.5-1.51.5-1.01.5-1.11.51.4-1.31.2-1.2
Parametrial fat weight0.51.11.90.80.8-0.80.7-1.11.2-1.1-1.11.2-1.11.4
Pavlov. Cond. lever latency2.12.63.7-1.4-1.31.3-1.81.8-1.91.61.6-1.71.3-1.7
Pavlov. Cond. magazine entry latency9.712.413.83.43.4-3.43.4-3.53.7-3.6-3.63.6-3.43.7
Pavlov. Cond. change in total contacts9.410.011.63.43.4-3.43.1-3.13.4-2.9-2.93.1-3.13.0
Pavlov. Cond. index score8.110.211.93.13.0-3.03.4-3.43.4-3.2-3.23.3-2.83.2
Pavlov. Cond. latency score6.07.69.32.62.5-2.52.9-2.93.0-2.8-2.82.9-2.52.8
Pavlov. Cond. lever contacts2.83.44.71.71.6-1.61.9-2.12.2-1.8-1.82.0-1.51.9
Pavlov. Cond. magazine entry number12.315.517.8-3.9-3.93.9-4.14.0-4.23.93.9-3.93.7-3.8
Pavlov. Cond. intertrial magazine entries1.21.52.5-1.1-1.11.1-1.01.2-1.61.21.3-1.21.2-1.4
Pavlov. Cond. lever-magazine prob. diff.9.712.013.93.43.3-3.33.6-3.73.7-3.5-3.53.5-3.13.4
Pavlov. Cond. response bias10.212.614.33.53.5-3.53.6-3.63.8-3.5-3.53.6-3.43.5
Pavlov. Cond. lever latency0.50.70.9-0.8-0.80.7-0.71.0-0.90.90.8-0.90.8-0.9
Pavlov. Cond. magazine entry latency0.00.10.2-0.3-0.30.3-0.20.2-0.40.10.1-0.20.2-0.2
Pavlov. Cond. change in total contacts0.60.91.61.21.1-1.11.0-1.31.0-0.7-0.71.0-0.60.6
Pavlov. Cond. index score0.10.20.40.40.4-0.30.5-0.60.4-0.4-0.40.5-0.20.3
Pavlov. Cond. latency score0.10.10.20.30.2-0.20.4-0.50.3-0.3-0.30.3-0.10.2
Pavlov. Cond. lever contacts0.50.71.00.70.7-0.70.9-1.00.9-0.8-0.80.9-0.70.9
Pavlov. Cond. magazine entry number0.10.10.2-0.2-0.20.2-0.40.3-0.10.20.2-0.30.3-0.3
Pavlov. Cond. intertrial magazine entries1.31.93.9-1.0-1.01.0-2.01.3-1.51.41.4-1.41.1-1.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.20.2-0.20.4-0.40.3-0.2-0.20.3-0.10.2
Pavlov. Cond. response bias1.01.41.61.11.1-1.01.2-1.31.2-1.2-1.21.3-1.11.2
Time in closed arm before self-admin1.92.44.51.71.7-1.71.9-1.52.1-1.3-1.11.3-1.41.1
Time in closed arm after self-admin0.10.10.3-0.1-0.10.1-0.40.5-0.00.50.5-0.5-0.0-0.4
Time in open arm before self-admin1.41.64.1-1.4-1.31.3-1.41.2-2.01.11.0-1.10.8-0.7
Time in open arm after self-admin0.20.20.5-0.5-0.50.5-0.60.5-0.70.20.4-0.50.4-0.4
Bone: periosteal estimation0.30.61.1-1.0-1.01.0-0.40.6-0.50.70.7-0.70.7-0.4
Bone: periosteal perimeter0.71.21.9-1.3-1.31.4-1.00.8-0.71.01.0-1.01.3-0.9
Bone: post-yield work1.31.82.4-1.4-1.41.4-1.41.2-1.01.51.5-1.41.3-1.3
Progressive ratio test 1 active lever presses0.10.10.70.10.1-0.20.80.00.3-0.1-0.10.2-0.40.3
Progressive ratio test 1 breakpoint0.10.10.50.00.0-0.10.70.10.20.0-0.00.1-0.20.2
Progressive ratio test 1 inactive lever presses0.20.30.70.50.5-0.60.4-0.20.6-0.6-0.60.6-0.80.6
Progressive ratio test 2 active lever presses1.01.11.31.11.1-1.11.1-1.11.0-1.1-1.11.1-0.90.8
Progressive ratio test 2 breakpoint1.01.21.41.11.1-1.11.1-1.11.0-1.2-1.11.2-0.90.9
Progressive ratio test 2 inactive lever presses0.10.20.50.50.5-0.50.5-0.50.5-0.7-0.60.5-0.30.2
Incentive Sensitization - Responses1.42.03.51.61.5-1.41.2-1.91.4-1.7-1.61.4-0.70.9
Incentive Sensitization - Breakpoint1.41.83.11.51.4-1.31.1-1.81.4-1.6-1.51.3-0.70.9
Sum of active levers in priming session hrs 5-60.20.20.7-0.1-0.1-0.00.80.20.1-0.1-0.20.1-0.60.7
Progressive ratio0.10.10.40.20.2-0.30.0-0.3-0.2-0.2-0.40.4-0.60.7
Food seeking constrained by brief footshock0.50.61.30.60.5-0.60.8-0.61.2-0.7-0.70.6-0.91.0
Seeking ratio, punishment vs. effort0.00.10.3-0.1-0.10.10.20.20.50.10.2-0.30.2-0.3
Retroperitoneal fat weight0.00.20.60.40.4-0.40.6-0.40.8-0.4-0.40.3-0.40.5
Reaction time number correct0.61.11.4-1.1-1.11.1-1.20.8-1.21.01.1-1.01.1-0.9
Reaction time mean minus median0.20.61.2-0.5-0.50.7-0.90.4-1.00.60.5-0.61.1-1.1
Reaction time mean minus median AUC0.00.10.3-0.0-0.10.2-0.1-0.1-0.20.1-0.0-0.10.6-0.5
Reaction time num false alarms0.50.61.20.60.5-0.51.0-1.00.8-1.1-1.10.7-0.50.8
Reaction time num false alarms AUC0.30.51.20.50.5-0.40.7-1.00.6-1.1-1.00.6-0.30.6
Reaction time trials correct on left0.61.11.4-1.1-1.11.1-1.20.8-1.21.01.1-1.01.1-0.9
Reaction time trials on left0.61.11.4-1.1-1.11.1-1.20.8-1.21.01.0-1.01.0-0.9
Reaction time mean0.30.40.70.80.8-0.8-0.1-0.40.3-0.8-0.70.7-0.70.4
Reaction time mean AUC0.30.40.70.80.8-0.8-0.1-0.40.3-0.7-0.70.7-0.80.5
Median of all reaction times1.11.62.31.41.5-1.50.5-0.91.0-1.4-1.41.3-1.51.2
Reaction time omissions0.40.61.20.90.9-0.80.0-0.80.6-1.1-1.10.7-0.70.7
Reaction time false alarm rate1.01.32.11.01.0-0.91.2-1.31.2-1.4-1.41.1-0.81.1
Reaction time premature initiation rate0.50.82.40.50.6-0.80.3-0.10.3-0.9-1.00.9-1.51.4
Reaction time premature initiations0.10.20.4-0.3-0.30.2-0.60.6-0.60.0-0.0-0.0-0.60.5
Std. dev. reaction times0.00.00.20.10.1-0.0-0.4-0.1-0.3-0.1-0.20.10.3-0.3
Reaction time trials completed0.61.11.4-1.1-1.11.1-1.20.8-1.21.01.0-1.01.0-0.9
Reaction time trials AUC0.51.01.5-1.0-1.01.0-1.10.7-1.21.01.0-1.01.1-1.0
Run reversals in cocaine runway, females1.71.73.4-1.3-1.21.1-1.11.9-1.81.21.4-1.40.6-1.1
Run reversals in cocaine runway, males0.20.20.40.40.4-0.40.6-0.30.6-0.5-0.30.3-0.30.3
Latency to leave start box in cocaine runway1.41.52.5-1.2-1.11.1-1.61.1-1.11.11.3-1.31.3-1.4
Latency to leave start box in cocaine runway, F2.02.33.4-1.6-1.51.5-1.81.6-1.51.31.5-1.51.3-1.4
Latency to leave start box in cocaine runway, M0.10.10.40.50.5-0.50.1-0.60.4-0.3-0.20.1-0.1-0.0
Std. dev. time between licks in bursts0.00.10.2-0.2-0.30.4-0.4-0.1-0.10.10.2-0.00.4-0.2
Total sessions with >9 infusions0.10.20.40.40.5-0.60.3-0.00.4-0.5-0.40.4-0.60.2
Short access day 1 total inactive lever presses1.62.13.31.51.5-1.61.3-1.31.4-1.8-1.61.3-1.41.2
Short access day 10 total inactive lever presses0.10.11.00.20.2-0.2-1.0-0.2-0.1-0.5-0.40.30.0-0.1
Short access day 1 total infusions0.30.41.40.50.6-0.80.60.10.7-0.6-0.50.5-1.20.7
Short access day 10 total infusions0.40.50.70.60.6-0.70.8-0.40.8-0.8-0.70.6-0.70.6
Short access total infusions0.30.41.10.50.6-0.70.5-0.10.5-0.8-0.60.6-1.10.8
Short access day 1 locomotion1.01.21.91.11.1-1.21.1-0.81.2-1.2-1.11.0-1.41.1
Short access day 10 total locomotion1.12.03.11.51.4-1.41.8-1.81.5-1.4-1.51.3-0.81.0
Short access total locomotion0.20.30.50.60.6-0.60.7-0.60.5-0.6-0.60.4-0.30.3
One hour access (0.3 mA shock)0.20.30.9-0.5-0.40.4-0.40.5-1.00.50.5-0.30.4-0.5
Compulsive drug intake0.20.20.8-0.1-0.10.10.10.5-0.50.60.6-0.30.4-0.9
One hour access (shock baseline)0.00.00.1-0.1-0.1-0.0-0.30.2-0.1-0.1-0.10.1-0.40.4
Social response proportion0.40.50.7-0.8-0.80.70.10.8-0.80.70.8-0.80.5-0.5
Social responses0.10.11.0-0.2-0.20.11.0-0.10.30.10.0-0.0-0.10.4
Social time0.10.10.3-0.5-0.50.60.2-0.0-0.20.10.0-0.10.5-0.1
Soleus weight0.10.20.5-0.6-0.70.70.40.0-0.20.20.2-0.10.40.1
Bone: stiffness0.10.10.3-0.4-0.30.20.10.40.10.10.1-0.0-0.50.5
Tibialis anterior weight1.75.87.3-2.7-2.72.6-2.42.6-2.32.42.4-2.32.0-1.9
Time to tail flick, vehicle, before self-admin0.20.20.50.20.10.10.3-0.60.6-0.3-0.10.00.7-0.5
Time to tail flick, vehicle, after self-admin0.00.10.20.20.1-0.00.2-0.5-0.0-0.1-0.20.50.00.3
Time to tail flick, test, before self-admin1.01.01.3-1.1-1.11.1-1.01.1-1.11.00.9-0.90.9-0.8
Time to tail flick, test, after self-admin0.20.20.80.10.00.10.9-0.60.7-0.4-0.2-0.00.5-0.1
Delta time to tail flick, vehicle, before/after SA0.40.41.00.40.4-0.40.7-0.70.3-0.5-0.70.8-0.71.0
Delta time to tail flick, test, before/after SA2.42.54.71.61.5-1.52.2-1.91.8-1.8-1.41.2-0.91.1
Tibia length1.85.07.4-2.7-2.72.6-1.62.4-1.92.12.2-2.22.0-1.7
Ambulatory time before self-admin0.00.00.10.10.1-0.2-0.3-0.10.2-0.2-0.20.3-0.30.3
Ambulatory time after self-admin1.51.72.5-1.6-1.51.5-1.51.6-0.71.31.3-1.11.0-0.9
Bone: tissue strength1.51.52.3-1.1-1.11.2-1.10.9-1.21.31.3-1.31.5-1.5
Total heroin consumption2.73.24.41.61.6-1.51.5-2.01.6-2.1-2.01.8-1.72.1
Bone: trabecular number5.48.910.52.72.7-2.83.1-2.93.0-3.2-3.23.0-3.03.2
Bone: trabecular spacing2.02.73.7-1.9-1.91.9-1.41.7-1.51.51.6-1.51.6-1.4
Bone: trabecular thickness0.10.10.30.30.3-0.20.1-0.50.4-0.4-0.40.3-0.10.2
Bone: trabecular tissue density0.10.10.40.20.3-0.3-0.20.2-0.60.40.4-0.3-0.0-0.5
Water consumed over 24 hours0.10.20.5-0.4-0.40.5-0.30.1-0.20.40.3-0.40.7-0.6
Number of responses in last shaping day0.30.30.70.70.7-0.70.5-0.40.8-0.6-0.60.4-0.3-0.0