Hub : Genes

Rara

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Rara 0.09 0.06 9.8e-07 0.06 0.06 0.05 0.06 6.8e-07 5.8e-07 2.7e-06 1.0e-06
2 Liver alternative TSS XM_039085219.1 0.05 0.03 3.8e-05 0.04 0.03 0.03 0.04 4.8e-05 4.9e-04 2.1e-04 7.8e-05
3 Liver intron excision ratio chr10_83893592_83902691 0.03 0.02 2.9e-03 0.02 0.01 0.01 0.02 4.3e-03 7.6e-03 6.5e-02 3.7e-03
4 Liver alternative TSS XM_039085214.1 0.05 0.03 7.1e-06 0.06 0.04 0.05 0.06 3.5e-07 4.4e-05 1.3e-06 5.1e-07
5 Liver alternative TSS XM_039085214.1 0.06 0.03 2.2e-06 0.06 0.04 0.06 0.06 1.0e-07 1.8e-05 3.4e-07 1.4e-07
6 Liver alternative TSS XM_039085217.1 0.08 0.05 9.0e-07 0.06 0.04 0.04 0.06 4.6e-07 7.0e-05 9.1e-05 4.7e-07
7 Liver isoform ratio XM_039085214.1 0.06 0.04 2.0e-06 0.06 0.04 0.06 0.06 9.6e-08 1.5e-05 2.7e-07 1.0e-07
8 Liver intron excision ratio chr10_83893592_83905392 0.06 0.04 2.3e-05 0.04 0.03 0.04 0.04 1.9e-05 3.5e-04 6.8e-05 3.0e-05
9 pVTA mRNA stability Rara 0.12 0.11 4.5e-03 0.07 -0 0.04 0.04 4.7e-04 4.0e-01 1.1e-02 5.6e-03
10 OFC gene expression Rara 0.16 0.1 3.0e-03 0.06 0.09 0.05 0.1 1.6e-02 3.2e-03 3.1e-02 2.6e-03
11 Liver gene expression Rara 0.04 0.03 6.0e-04 0.03 0.01 0.01 0.02 1.3e-04 7.0e-03 8.2e-03 1.2e-03
12 Brain mRNA stability Rara 0.04 0.03 1.6e-03 0.02 0.03 0.02 0.02 1.2e-02 1.4e-03 6.4e-03 5.4e-03
13 Liver isoform ratio XM_039085218.1 0.04 0.03 4.3e-03 0.01 0.01 0 0.01 1.9e-02 1.6e-02 1.3e-01 4.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density2.54.24.4-1.92.02.0-2.1-2.12.1-2.12.12.12.0-2.0-2.1-2.0
Area under the delay curve0.20.20.5-0.30.30.5-0.4-0.40.4-0.40.40.40.4-0.4-0.7-0.1
BMI with tail2.37.38.22.8-2.7-2.22.82.8-2.82.8-2.8-2.8-2.92.72.81.8
BMI without tail0.20.40.50.4-0.5-0.10.70.7-0.70.7-0.7-0.7-0.60.40.70.4
Body weight4.619.122.24.7-4.5-4.24.54.5-4.54.5-4.5-4.5-4.64.44.33.1
Weight adjusted by age0.20.31.10.5-0.6-1.10.60.6-0.60.6-0.6-0.6-0.20.2-0.0-0.1
Bone surface0.10.10.7-0.20.20.3-0.2-0.20.2-0.20.20.20.1-0.1-0.2-0.8
Bone volume0.30.51.6-0.50.60.7-0.7-0.70.7-0.70.70.70.4-0.4-0.4-1.3
Breakpoint value in progressive ratio session0.20.20.9-0.40.4-1.00.20.2-0.20.2-0.2-0.20.4-0.6-0.6-0.4
Number of licking bursts0.30.31.4-0.60.40.3-0.5-0.50.5-0.50.50.50.6-0.6-0.2-1.2
Context. condit. distance diff. score1.51.85.11.6-1.3-1.31.01.0-1.01.0-1.0-1.0-1.61.70.92.3
Locomotion velocity, session 10.40.40.60.7-0.6-0.80.60.6-0.60.6-0.6-0.6-0.60.60.60.2
Locomotion distance, session 11.62.13.31.6-1.7-1.81.41.4-1.41.4-1.4-1.4-1.51.61.60.7
Locomotion velocity, session 20.20.20.30.3-0.4-0.50.60.6-0.60.6-0.6-0.6-0.30.30.10.3
Locomotion distance, session 20.10.10.40.2-0.3-0.50.10.1-0.10.1-0.1-0.1-0.00.00.2-0.6
Locomotion velocity, session 30.00.00.2-0.30.10.1-0.1-0.10.1-0.10.10.10.3-0.2-0.40.0
Locomotion distance, session 30.10.10.40.3-0.6-0.60.40.4-0.40.4-0.4-0.4-0.30.40.40.2
Stereotopy head waving bouts, day 32.12.43.6-1.51.81.9-1.5-1.51.5-1.51.51.51.5-1.6-1.9-0.9
Stereotopy head waving duration, day 30.10.10.4-0.10.40.6-0.1-0.10.1-0.10.10.10.1-0.1-0.60.1
Locomotion velocity, session 70.91.02.10.9-1.2-1.41.01.0-1.01.0-1.0-1.0-0.81.01.20.2
Locomotion distance, session 70.50.61.40.5-0.8-1.10.70.7-0.70.7-0.7-0.7-0.60.81.20.2
Stereotopy head waving bouts, day 70.50.61.1-0.50.70.8-0.8-0.80.8-0.80.80.80.7-0.7-1.1-0.6
Stereotopy head waving duration, day 70.30.41.2-0.30.50.6-0.6-0.60.6-0.60.60.60.6-0.6-1.1-0.3
Locomotion velocity, session 87.69.110.73.3-3.1-3.12.92.9-2.92.9-2.9-2.9-3.13.22.83.1
Locomotion distance, session 81.01.52.31.5-1.3-1.51.11.1-1.11.1-1.1-1.1-1.41.51.11.2
Degree of sensitization distance1.41.42.31.0-1.0-1.21.21.2-1.21.2-1.2-1.2-1.21.31.51.0
Degree of sensitization stereotypy0.91.01.3-0.70.90.9-1.1-1.11.1-1.11.11.11.0-0.9-1.1-0.8
Conditioned locomotion0.20.20.6-0.30.20.2-0.5-0.50.5-0.50.50.50.5-0.5-0.8-0.1
Cocaine response after cond. corrected0.70.81.3-0.60.70.7-0.9-0.90.9-0.90.90.90.9-0.9-0.9-1.1
Cocaine response after cond. not corrected0.91.01.8-0.80.80.7-1.0-1.01.0-1.01.01.01.0-1.0-1.0-1.3
Cocaine response before conditioning0.00.10.1-0.40.30.1-0.2-0.20.2-0.20.20.20.2-0.1-0.2-0.2
Saline control response0.20.20.40.6-0.5-0.60.50.5-0.50.5-0.5-0.5-0.50.50.40.1
Bone: connectivity density3.55.56.1-2.32.32.2-2.4-2.42.4-2.42.42.42.3-2.3-2.5-2.2
Bone: cortical apparent density5.57.28.9-2.93.02.6-2.8-2.82.8-2.82.82.82.6-2.6-2.4-1.7
Bone: cortical area0.00.10.2-0.30.20.2-0.3-0.30.3-0.30.30.30.2-0.2-0.3-0.4
Bone: cortical porosity0.20.20.4-0.20.30.4-0.4-0.40.4-0.40.40.40.4-0.4-0.5-0.7
Bone: cortical porosity0.10.10.30.00.20.2-0.3-0.30.3-0.30.30.30.2-0.2-0.4-0.5
Bone: cortical thickness0.81.42.2-1.21.20.8-1.3-1.31.3-1.31.31.31.1-1.2-1.5-0.6
Bone: cortical thickness5.46.310.0-2.22.62.2-2.6-2.62.6-2.62.62.62.6-2.4-3.2-1.6
Bone: cortical tissue density5.57.29.0-2.93.02.6-2.8-2.82.8-2.82.82.82.6-2.6-2.4-1.8
Condit. Reinf. active minus inactive responses0.80.91.6-1.01.00.7-0.9-0.90.9-0.90.90.91.1-1.1-1.3-0.4
Condit. Reinf. active-inactive response ratio0.80.91.9-1.11.10.8-0.9-0.90.9-0.90.90.91.1-1.1-1.4-0.3
Condit. Reinf. active responses0.81.01.4-1.01.10.7-1.0-1.01.0-1.01.01.01.1-1.1-1.2-0.5
Condit. Reinf. inactive responses0.20.20.3-0.30.30.1-0.5-0.50.5-0.50.50.50.4-0.4-0.2-0.5
Incentive salience index mean1.82.22.9-1.71.61.4-1.4-1.41.4-1.41.41.41.6-1.6-1.5-1.2
Condit. Reinf. lever presses0.91.22.0-1.41.21.0-1.0-1.01.0-1.01.01.01.1-1.1-0.8-1.4
Condit. Reinf. active minus inactive responses1.41.72.5-1.51.41.2-1.3-1.31.3-1.31.31.31.4-1.3-1.0-1.6
Condit. Reinf. active-inactive response ratio1.31.42.3-1.31.21.2-1.2-1.21.2-1.21.21.21.2-1.1-0.7-1.5
Condit. Reinf. active responses2.23.14.5-1.91.81.7-1.7-1.71.7-1.71.71.71.9-1.8-1.4-2.1
Condit. Reinf. inactive responses2.12.63.2-1.71.61.6-1.6-1.61.6-1.61.61.61.7-1.7-1.5-1.8
Condit. Reinf. lever presses0.10.20.4-0.50.40.5-0.4-0.40.4-0.40.40.40.5-0.5-0.6-0.4
Condit. Reinf. lever reinforcers received2.23.14.0-1.91.81.7-1.7-1.71.7-1.71.71.71.9-1.8-1.6-2.0
Conditioned reinforcement - actives0.80.81.2-1.00.90.3-0.9-0.90.9-0.90.90.90.9-1.1-0.6-0.8
Conditioned reinforcement - inactives2.42.73.3-1.71.81.7-1.8-1.81.8-1.81.81.81.3-1.6-0.9-1.1
Conditioned locomotion0.50.51.3-1.00.60.1-0.7-0.70.7-0.70.70.70.8-1.0-0.4-1.2
Patch foraging indifference point 0 sec1.72.74.3-2.11.61.7-1.6-1.61.6-1.61.61.61.6-1.6-1.4-1.5
Patch foraging indifference point AUC0.10.10.20.2-0.4-0.50.20.2-0.20.2-0.2-0.20.10.20.1-0.0
Delay disc. indifference point, 0s delay0.80.91.7-1.11.31.0-0.7-0.70.7-0.70.70.71.0-1.0-1.1-1.0
Delay disc. indifference point, 16s delay0.20.21.10.10.30.6-0.3-0.30.3-0.30.30.30.2-0.2-1.00.8
Delay disc. indifference point, 2s delay0.91.01.8-1.11.00.8-1.0-1.01.0-1.01.01.01.0-1.0-0.8-1.4
Delay disc. indifference point, 24s delay0.10.10.20.2-0.40.00.40.4-0.40.4-0.4-0.4-0.30.30.30.5
Delay disc. indifference point, 4s delay0.90.92.0-0.60.80.6-1.0-1.01.0-1.01.01.01.0-1.0-1.4-0.6
Delay disc. indifference point, 8s delay0.10.10.1-0.30.00.3-0.4-0.40.4-0.40.40.40.3-0.3-0.2-0.3
Indifference point function ln k0.10.10.30.10.0-0.00.30.3-0.30.3-0.3-0.3-0.40.1-0.10.6
Indifference point function log k0.10.10.30.10.0-0.00.30.3-0.30.3-0.3-0.3-0.40.1-0.10.6
Patch foraging total patch changes 0 sec1.21.93.3-1.81.31.4-1.4-1.41.4-1.41.41.41.3-1.3-1.0-1.3
Patch foraging total patch changes 12 sec6.07.89.9-3.12.62.4-2.8-2.82.8-2.82.82.83.0-2.6-2.4-3.1
Patch foraging total patch changes 18 sec0.50.71.3-1.10.50.7-0.8-0.80.8-0.80.80.80.9-0.9-0.5-1.1
Patch foraging total patch changes 24 sec1.61.92.2-1.41.10.7-1.5-1.51.5-1.51.51.51.5-1.3-1.5-1.4
Patch foraging total patch changes 6 sec2.13.14.1-2.01.71.9-1.8-1.81.8-1.81.81.81.8-1.6-1.5-1.7
Patch foraging time to switch 0 sec0.10.10.3-0.40.40.3-0.3-0.30.3-0.30.30.30.5-0.4-0.4-0.5
Patch foraging water rate 0 sec0.10.10.1-0.30.20.4-0.4-0.40.4-0.40.40.40.2-0.3-0.3-0.1
Patch foraging water rate 12 sec0.00.00.40.10.0-0.60.10.1-0.10.1-0.1-0.1-0.1-0.2-0.20.2
Patch foraging water rate 18 sec0.70.91.3-0.81.00.7-1.0-1.01.0-1.01.01.00.8-1.0-1.1-1.2
Patch foraging water rate 24 sec0.81.21.6-1.11.21.3-1.1-1.11.1-1.11.11.10.8-0.9-0.8-1.0
Patch foraging water rate 6 sec2.13.03.3-1.71.61.6-1.8-1.81.8-1.81.81.81.7-1.7-1.8-1.5
Seeking ratio, delayed vs. immediate footshock0.30.30.4-0.40.6-0.1-0.6-0.60.6-0.60.60.60.4-0.4-0.60.7
Distance traveled before self-admin0.10.10.20.10.00.50.30.3-0.30.3-0.3-0.3-0.1-0.1-0.0-0.2
Distance traveled after self-admin2.12.33.71.3-1.1-0.51.91.9-1.91.9-1.9-1.9-1.21.11.11.1
Extensor digitorum longus weight9.939.141.16.2-6.3-6.36.46.4-6.46.4-6.4-6.4-6.36.16.15.5
Bone: elastic displacement0.00.00.2-0.20.1-0.20.00.0-0.00.0-0.0-0.0-0.10.00.4-0.1
Bone: elastic work0.10.20.2-0.30.40.2-0.5-0.50.5-0.50.50.50.3-0.3-0.5-0.4
Bone: endosteal estimation1.83.95.12.0-2.2-1.52.02.0-2.02.0-2.0-2.0-2.12.12.30.8
Bone: endosteal perimeter1.12.33.71.4-1.6-1.11.61.6-1.61.6-1.6-1.6-1.61.61.90.7
Epididymis fat weight0.00.00.20.0-0.2-0.40.20.2-0.20.2-0.2-0.2-0.10.10.2-0.5
Delta time in closed arm before/after self-admin3.73.65.32.2-2.0-2.31.71.7-1.71.7-1.7-1.7-1.92.11.81.8
Delta time in open arm before/after self-admin0.00.00.20.20.20.50.10.1-0.10.1-0.1-0.1-0.20.1-0.00.4
Diff in mean of infusions in LGA sessions0.30.31.3-0.10.1-1.10.70.7-0.70.7-0.7-0.70.3-0.3-0.4-0.2
Delay discount exponential model param0.10.10.30.1-0.1-0.30.30.3-0.30.3-0.3-0.3-0.20.20.6-0.1
Extinction: sum of active levers before priming1.71.72.31.3-1.4-1.51.31.3-1.31.3-1.3-1.3-1.41.21.40.7
Active lever presses in extinction session 62.12.04.3-1.21.10.8-1.4-1.41.4-1.41.41.41.3-1.5-1.8-2.1
Bone: final force0.71.12.4-0.80.81.0-1.1-1.11.1-1.11.11.10.8-0.9-0.9-1.6
Bone: final moment0.40.71.9-0.60.60.8-0.9-0.90.9-0.90.90.90.6-0.7-0.7-1.4
Food consumed during 24 hour testing period0.60.71.10.9-0.8-0.70.80.8-0.80.8-0.8-0.8-1.01.01.00.7
Glucose0.00.00.1-0.10.20.1-0.1-0.10.1-0.10.10.10.00.1-0.2-0.4
Heart weight3.85.37.12.2-2.0-2.32.22.2-2.22.2-2.2-2.2-2.72.62.62.0
Delay discount hyperbolic model param0.10.10.40.2-0.3-0.40.40.4-0.40.4-0.4-0.4-0.30.40.70.0
Intermittent access intake day 1-15 change0.80.81.1-0.70.90.7-1.0-1.01.0-1.01.01.00.7-1.1-1.0-0.4
Intermittent access intake escalation0.80.81.3-0.70.90.6-1.0-1.01.0-1.01.01.00.7-1.1-1.1-0.4
Intermittent access intake escalation 20.10.10.2-0.10.20.2-0.4-0.40.4-0.40.40.40.1-0.3-0.3-0.1
Intermitt. access day 1 inactive lever presses2.83.04.8-1.31.72.0-1.8-1.81.8-1.81.81.81.6-1.6-2.2-1.1
Intermitt. access day 15 inactive lever presses4.75.26.0-2.32.22.4-2.3-2.32.3-2.32.32.32.3-2.4-2.4-1.7
Intermitt. access escalation Index2.32.02.81.7-1.4-1.21.51.5-1.51.5-1.5-1.5-1.51.50.91.2
Intermittent access day 1 total infusions0.20.20.3-0.50.50.4-0.5-0.50.5-0.50.50.50.5-0.4-0.4-0.5
Intermittent access day 15 total infusions0.91.01.6-0.71.00.8-1.1-1.11.1-1.11.11.10.9-1.0-1.3-0.3
Intermittent access terminal intake (last 3 days)1.11.21.5-0.81.11.0-1.2-1.21.2-1.21.21.21.0-1.1-1.2-0.5
Intermittent access total infusions0.40.50.6-0.40.60.5-0.8-0.80.8-0.80.80.80.5-0.6-0.8-0.2
Intermittent access day 1 locomotion0.20.20.4-0.70.40.4-0.4-0.40.4-0.40.40.40.4-0.5-0.0-0.5
Intermittent access day 15 total locomotion0.50.50.8-0.90.60.4-0.8-0.80.8-0.80.80.80.5-0.60.1-0.8
Intermittent access total locomotion0.80.91.3-1.10.90.8-1.0-1.01.0-1.01.01.01.0-1.1-0.6-0.8
Intermittent access standard deviation3.33.44.3-1.61.81.5-2.1-2.12.1-2.12.12.11.9-1.9-1.8-1.0
Left kidney weight1.23.34.12.0-1.8-1.22.02.0-2.02.0-2.0-2.0-1.71.60.72.0
Right kidney weight0.10.40.90.9-0.6-0.50.60.6-0.60.6-0.6-0.6-0.50.5-0.20.5
Cocaine induced anxiety1.82.03.01.7-1.4-1.21.51.5-1.51.5-1.5-1.5-1.51.51.00.9
Post-drug Anxiety0.20.20.60.7-0.4-0.30.50.5-0.50.5-0.5-0.5-0.50.50.10.5
Baseline Anxiety1.11.11.7-1.31.10.9-1.1-1.11.1-1.11.11.11.1-1.1-0.7-0.5
Tail length0.20.50.70.7-0.7-0.90.70.7-0.70.7-0.7-0.7-0.50.40.30.9
Length with tail2.17.99.83.1-3.0-3.12.82.8-2.82.8-2.8-2.8-2.92.72.22.6
Length without tail2.76.08.02.8-2.6-2.82.42.4-2.42.4-2.4-2.4-2.62.62.01.8
Times rat made contact with spout1.11.31.7-1.11.21.3-1.2-1.21.2-1.21.21.20.9-1.0-0.4-1.2
Lifetime Intake0.50.61.0-0.40.70.6-0.8-0.80.8-0.80.80.80.7-0.8-1.0-0.2
Liver weight, left0.10.10.2-0.30.1-0.2-0.3-0.30.3-0.30.30.30.4-0.4-0.3-0.3
Liver weight, right0.61.03.8-0.51.00.9-0.9-0.90.9-0.90.90.91.0-0.9-2.0-0.6
Locomotor activity0.81.32.6-1.10.80.7-1.1-1.11.1-1.11.11.11.2-1.2-1.0-1.6
Locomotor testing distance2.44.04.7-2.11.71.9-2.0-2.02.0-2.02.02.02.2-2.1-1.9-2.0
Locomotor testing rearing6.29.611.9-3.22.93.4-3.1-3.13.1-3.13.13.13.2-3.2-3.3-2.4
Locomotion in novel chamber4.75.87.5-2.52.62.1-2.3-2.32.3-2.32.32.32.5-2.6-2.7-2.1
Locomotion in novel chamber post-restriction1.21.43.1-1.41.31.0-1.1-1.11.1-1.11.11.11.3-1.3-0.7-1.8
Fecal boli incidents, locomotor time 10.40.51.30.4-0.7-0.50.70.7-0.70.7-0.7-0.7-0.60.51.10.3
Change in fecal boli incidents, locomotor task0.00.00.10.2-0.2-0.40.20.2-0.20.2-0.2-0.2-0.20.3-0.10.1
Time >=10cm from walls, locomotor time 10.00.00.2-0.40.2-0.1-0.1-0.10.1-0.10.10.10.3-0.3-0.30.0
Bouts of movement, locomotor time 10.20.21.00.7-1.0-0.50.40.4-0.40.4-0.4-0.4-0.40.30.30.4
Total resting periods, locomotor time 10.60.72.01.1-1.4-0.90.70.7-0.70.7-0.7-0.7-0.70.80.80.6
Rest time, locomotor task time 10.10.10.6-0.30.00.5-0.2-0.20.2-0.20.20.20.2-0.20.3-0.8
Distance moved, locomotor task time 10.00.00.30.10.4-0.1-0.1-0.10.1-0.10.10.10.10.0-0.50.4
Vertical activity count, locomotor time 10.20.21.10.4-0.3-1.00.40.4-0.40.4-0.4-0.4-0.40.40.20.5
Time >=10cm from walls, locomotor time 21.21.31.9-1.30.90.2-1.2-1.21.2-1.21.21.21.2-1.3-1.1-1.4
Bouts of movement, locomotor time 20.30.31.0-0.50.20.5-0.4-0.40.4-0.40.40.40.6-0.8-1.0-0.3
Total resting periods, locomotor time 20.20.20.7-0.30.10.3-0.3-0.30.3-0.30.30.30.5-0.6-0.9-0.1
Rest time, locomotor task time 20.60.71.00.9-0.9-1.00.80.8-0.80.8-0.8-0.8-0.80.81.00.6
Distance moved, locomotor task time 20.10.20.20.5-0.1-0.40.40.4-0.40.4-0.4-0.4-0.50.50.10.3
Vertical activity count, locomotor time 20.50.50.90.7-0.5-0.90.80.8-0.80.8-0.8-0.8-0.70.60.50.7
Light reinforcement 13.46.26.9-2.52.32.5-2.5-2.52.5-2.52.52.52.6-2.4-2.4-2.3
Light reinforcement 20.60.81.3-0.70.91.1-0.9-0.90.9-0.90.90.90.9-0.6-0.9-1.1
Bone: marrow area1.73.64.82.0-2.1-1.42.02.0-2.02.0-2.0-2.0-2.02.02.20.7
Bone: maximum diameter0.00.10.4-0.30.20.4-0.2-0.20.2-0.20.20.20.3-0.3-0.2-0.6
Bone: maximum force0.00.00.30.2-0.20.10.10.1-0.10.1-0.1-0.1-0.30.20.1-0.5
Bone: maximum moment0.10.10.20.3-0.4-0.10.30.3-0.30.3-0.3-0.3-0.50.40.3-0.3
Mean time between licks in bursts1.21.73.60.9-1.3-0.91.41.4-1.41.4-1.4-1.4-1.31.21.90.4
Mean num. licks in bursts0.10.10.4-0.20.50.7-0.4-0.40.4-0.40.40.40.1-0.1-0.20.4
Cd content in liver0.20.20.3-0.20.20.6-0.6-0.60.6-0.60.60.60.1-0.3-0.5-0.0
Co content in liver0.60.71.81.0-0.6-0.80.70.7-0.70.7-0.7-0.7-0.80.90.91.4
Cu content in liver0.10.10.40.10.0-0.0-0.3-0.30.3-0.30.30.30.0-0.0-0.20.6
Fe content in liver0.91.01.41.2-1.1-1.11.11.1-1.11.1-1.1-1.1-0.91.00.70.7
K content in liver1.61.63.8-1.11.11.1-1.2-1.21.2-1.21.21.21.4-1.4-1.9-1.1
Mg content in liver1.21.23.3-0.90.91.0-1.1-1.11.1-1.11.11.11.2-1.2-1.8-0.1
Mn content in liver2.83.24.7-1.71.61.7-1.8-1.81.8-1.81.81.81.8-1.8-2.2-1.3
Na content in liver0.40.51.1-0.40.50.5-0.6-0.60.6-0.60.60.60.8-0.7-0.9-1.1
Rb content in liver1.31.62.3-1.41.41.5-1.3-1.31.3-1.31.31.31.3-1.2-1.2-0.9
Se content in liver6.07.49.5-2.62.82.8-2.7-2.72.7-2.72.72.72.8-2.8-3.1-1.9
Sr content in liver0.10.10.2-0.40.30.2-0.3-0.30.3-0.30.30.30.3-0.3-0.30.0
Zn content in liver3.84.25.1-2.02.22.2-2.1-2.12.1-2.12.12.11.9-1.9-1.8-1.6
Bone: minimum diameter0.50.91.10.9-1.0-0.71.11.1-1.11.1-1.1-1.1-1.01.00.80.4
Time in familiar zone, hab. session 10.40.31.3-0.30.70.8-0.5-0.50.5-0.50.50.50.3-0.3-0.4-1.1
Time in novel zone, hab. session 10.40.40.7-0.80.60.5-0.6-0.60.6-0.60.60.60.6-0.6-0.30.2
Total zone transitions, hab. session 11.62.23.01.7-1.4-1.51.31.3-1.31.3-1.3-1.3-1.61.71.51.7
Total locomotion distance, hab. session 10.00.10.20.20.2-0.1-0.3-0.30.3-0.30.30.3-0.20.3-0.10.5
Locomotion velocity, hab. session 10.20.30.70.7-0.4-0.60.40.4-0.40.4-0.4-0.4-0.60.60.20.9
Time in familiar zone, hab. session 20.70.71.0-0.40.90.9-0.9-0.90.9-0.90.90.90.7-0.7-1.0-0.6
Time in novel zone, hab. session 20.10.10.5-0.70.30.3-0.2-0.20.2-0.20.20.20.5-0.5-0.1-0.4
Total zone transitions, hab. session 20.91.22.01.1-1.1-1.30.90.9-0.90.9-0.9-0.9-1.21.31.40.8
Total locomotion distance, hab. session 20.20.20.70.5-0.3-0.60.30.3-0.30.3-0.3-0.3-0.60.60.80.2
Locomotion velocity, hab. session 20.30.40.90.7-0.6-0.90.50.5-0.50.5-0.5-0.5-0.80.81.00.4
Novel to familiar place preference ratio1.21.31.91.2-1.2-1.11.21.2-1.21.2-1.2-1.2-0.80.80.41.4
Novelty place preference1.21.22.11.1-1.2-1.01.21.2-1.21.2-1.2-1.2-0.80.70.31.4
Time in novel zone, NPP test0.50.51.10.7-0.7-0.60.80.8-0.80.8-0.8-0.8-0.40.3-0.01.1
Total zone transitions, NPP test0.40.51.90.7-0.7-0.80.40.4-0.40.4-0.4-0.4-0.91.11.40.0
Total locomotion distance, NPP test0.10.10.3-0.00.2-0.0-0.3-0.30.3-0.30.30.3-0.30.40.6-0.5
Locomotion velocity, NPP test0.20.31.20.6-0.4-0.60.30.3-0.30.3-0.3-0.3-0.91.01.10.1
Intraocular pressure3.34.56.72.0-2.0-1.92.22.2-2.22.2-2.2-2.2-2.02.02.62.0
Delta distance traveled before/after self-admin1.81.92.21.5-1.3-1.31.41.4-1.41.4-1.4-1.4-1.21.31.21.5
Delta ambulatory time before/after self-admin1.41.51.91.3-1.3-1.01.41.4-1.41.4-1.4-1.4-1.01.11.11.0
Parametrial fat weight2.54.95.4-2.02.22.1-2.3-2.32.3-2.32.32.32.2-2.1-2.0-2.2
Pavlov. Cond. lever latency2.73.55.82.0-2.0-2.01.71.7-1.71.7-1.7-1.7-1.91.91.52.4
Pavlov. Cond. magazine entry latency10.113.014.2-3.63.83.7-3.6-3.63.6-3.63.63.63.6-3.6-3.4-3.5
Pavlov. Cond. change in total contacts8.38.911.4-3.13.33.4-2.9-2.92.9-2.92.92.93.0-2.9-3.1-2.3
Pavlov. Cond. index score8.110.311.7-3.33.43.3-3.2-3.23.2-3.23.23.23.2-3.2-2.8-3.4
Pavlov. Cond. latency score6.07.69.6-2.92.92.9-2.7-2.72.7-2.72.72.72.8-2.7-2.4-3.1
Pavlov. Cond. lever contacts2.32.75.0-1.81.81.8-1.5-1.51.5-1.51.51.51.7-1.7-1.1-2.2
Pavlov. Cond. magazine entry number12.315.417.34.0-4.2-4.24.04.0-4.04.0-4.0-4.0-3.83.83.63.6
Pavlov. Cond. intertrial magazine entries1.61.92.61.4-1.5-1.61.41.4-1.41.4-1.4-1.4-1.31.31.21.6
Pavlov. Cond. lever-magazine prob. diff.9.011.212.4-3.53.53.5-3.3-3.33.3-3.33.33.33.3-3.3-2.9-3.5
Pavlov. Cond. response bias9.211.112.4-3.43.53.5-3.3-3.33.3-3.33.33.33.3-3.2-3.2-3.1
Pavlov. Cond. lever latency0.50.60.80.9-0.8-0.80.80.8-0.80.8-0.8-0.8-0.80.80.60.9
Pavlov. Cond. magazine entry latency0.00.00.20.2-0.3-0.5-0.0-0.00.0-0.00.00.0-0.10.20.30.1
Pavlov. Cond. change in total contacts0.60.81.5-1.21.01.0-0.8-0.80.8-0.80.80.81.0-0.9-0.7-0.9
Pavlov. Cond. index score0.20.30.5-0.60.50.5-0.5-0.50.5-0.50.50.50.5-0.4-0.2-0.7
Pavlov. Cond. latency score0.10.10.3-0.40.30.3-0.4-0.40.4-0.40.40.40.3-0.3-0.1-0.6
Pavlov. Cond. lever contacts0.91.32.0-1.21.11.2-1.1-1.11.1-1.11.11.11.1-1.1-0.9-1.4
Pavlov. Cond. magazine entry number0.00.00.10.1-0.1-0.00.30.3-0.30.3-0.3-0.3-0.10.10.10.2
Pavlov. Cond. intertrial magazine entries1.72.22.81.3-1.4-1.51.61.6-1.61.6-1.6-1.6-1.31.31.11.7
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.40.40.4-0.4-0.40.4-0.40.40.40.3-0.3-0.1-0.6
Pavlov. Cond. response bias1.31.82.2-1.31.31.3-1.4-1.41.4-1.41.41.41.3-1.3-1.2-1.5
Time in closed arm before self-admin0.60.73.7-1.11.01.9-0.2-0.20.2-0.20.20.20.8-0.9-0.9-0.6
Time in closed arm after self-admin0.80.91.80.9-0.7-0.41.01.0-1.01.0-1.0-1.0-0.80.90.41.3
Time in open arm before self-admin1.21.35.11.3-1.3-2.30.90.9-0.90.9-0.9-0.9-1.01.21.00.9
Time in open arm after self-admin0.30.30.60.6-0.5-0.60.40.4-0.40.4-0.4-0.4-0.50.70.80.6
Bone: periosteal estimation0.20.40.50.6-0.7-0.30.60.6-0.60.6-0.6-0.6-0.70.70.7-0.2
Bone: periosteal perimeter0.50.81.50.9-1.0-0.70.90.9-0.90.9-0.9-0.9-1.01.01.20.1
Bone: post-yield work1.52.02.91.4-1.6-1.21.41.4-1.41.4-1.4-1.4-1.71.61.51.0
Progressive ratio test 1 active lever presses0.50.51.2-0.60.61.1-0.7-0.70.7-0.70.70.70.6-0.7-0.8-0.4
Progressive ratio test 1 breakpoint0.40.41.0-0.50.61.0-0.6-0.60.6-0.60.60.60.6-0.7-0.8-0.3
Progressive ratio test 1 inactive lever presses1.92.13.6-1.21.41.9-1.4-1.41.4-1.41.41.41.3-1.4-1.7-0.8
Progressive ratio test 2 active lever presses1.61.72.2-1.31.41.5-1.3-1.31.3-1.31.31.31.2-1.4-1.0-0.9
Progressive ratio test 2 breakpoint1.11.21.8-1.11.21.3-1.1-1.11.1-1.11.11.11.0-1.2-0.9-0.8
Progressive ratio test 2 inactive lever presses0.81.01.2-0.91.01.0-1.1-1.11.1-1.11.11.10.8-0.9-0.7-0.6
Incentive Sensitization - Responses1.91.92.7-1.61.51.5-1.4-1.41.4-1.41.41.41.2-1.3-0.5-1.4
Incentive Sensitization - Breakpoint1.71.82.5-1.61.41.5-1.4-1.41.4-1.41.41.41.1-1.3-0.5-1.4
Sum of active levers in priming session hrs 5-60.50.51.1-0.40.6-0.0-0.8-0.80.8-0.80.80.80.4-0.5-1.1-0.6
Progressive ratio0.10.10.6-0.50.2-0.1-0.1-0.10.1-0.10.10.10.6-0.5-0.5-0.8
Food seeking constrained by brief footshock0.30.30.8-0.50.50.9-0.5-0.50.5-0.50.50.50.6-0.5-0.7-0.9
Seeking ratio, punishment vs. effort0.00.00.20.2-0.00.5-0.1-0.10.1-0.10.10.1-0.30.30.20.3
Retroperitoneal fat weight0.00.10.30.3-0.30.30.20.2-0.20.2-0.2-0.2-0.40.50.10.0
Reaction time number correct0.50.71.60.8-0.9-1.30.60.6-0.60.6-0.6-0.6-1.01.01.00.5
Reaction time mean minus median0.40.61.10.4-0.5-0.90.90.9-0.90.9-0.9-0.9-0.50.51.10.5
Reaction time mean minus median AUC0.00.10.4-0.0-0.1-0.20.20.2-0.20.2-0.2-0.2-0.10.10.60.1
Reaction time num false alarms0.70.92.1-0.90.80.9-1.1-1.11.1-1.11.11.10.8-0.7-0.4-1.4
Reaction time num false alarms AUC0.60.82.4-1.00.70.7-0.9-0.90.9-0.90.90.90.7-0.7-0.3-1.5
Reaction time trials correct on left0.50.71.60.8-0.9-1.30.60.6-0.60.6-0.6-0.6-1.01.01.00.5
Reaction time trials on left0.40.61.60.8-0.9-1.30.60.6-0.60.6-0.6-0.6-1.01.01.00.4
Reaction time mean0.20.30.5-0.50.70.4-0.4-0.40.4-0.40.40.40.6-0.7-0.70.1
Reaction time mean AUC0.20.30.6-0.40.70.3-0.4-0.40.4-0.40.40.40.6-0.7-0.80.2
Median of all reaction times1.11.52.3-1.11.41.2-1.2-1.21.2-1.21.21.21.2-1.4-1.5-0.4
Reaction time omissions1.31.72.0-1.31.41.2-1.4-1.41.4-1.41.41.41.3-1.2-1.1-1.2
Reaction time false alarm rate0.91.32.4-1.21.01.3-1.1-1.11.1-1.11.11.11.1-1.1-0.8-1.6
Reaction time premature initiation rate0.60.82.8-0.40.90.3-0.9-0.90.9-0.90.90.91.1-1.0-1.7-0.3
Reaction time premature initiations0.10.10.60.30.2-0.6-0.3-0.30.3-0.30.30.30.2-0.1-0.80.2
Std. dev. reaction times0.00.10.1-0.10.1-0.30.30.3-0.30.3-0.3-0.30.0-0.10.30.1
Reaction time trials completed0.40.61.60.8-0.9-1.30.60.6-0.60.6-0.6-0.6-1.01.01.00.4
Reaction time trials AUC0.40.61.60.7-0.9-1.30.60.6-0.60.6-0.6-0.6-0.91.01.00.5
Run reversals in cocaine runway, females2.52.46.01.9-1.3-1.91.31.3-1.31.3-1.3-1.3-1.61.60.92.5
Run reversals in cocaine runway, males0.50.50.9-0.50.81.0-0.8-0.80.8-0.80.80.80.5-0.5-0.6-0.2
Latency to leave start box in cocaine runway1.31.52.21.3-1.2-1.21.11.1-1.11.1-1.1-1.1-1.51.41.21.3
Latency to leave start box in cocaine runway, F1.31.52.21.5-1.2-1.21.11.1-1.11.1-1.1-1.1-1.41.31.01.3
Latency to leave start box in cocaine runway, M0.20.10.3-0.50.40.6-0.4-0.40.4-0.40.40.40.1-0.2-0.3-0.1
Std. dev. time between licks in bursts0.00.00.3-0.1-0.2-0.10.10.1-0.10.1-0.1-0.1-0.10.00.4-0.5
Total sessions with >9 infusions0.70.81.2-0.60.81.0-1.0-1.01.0-1.01.01.00.7-0.9-1.1-0.2
Short access day 1 total inactive lever presses2.73.03.7-1.51.81.6-1.9-1.91.9-1.91.91.91.6-1.5-1.6-1.1
Short access day 10 total inactive lever presses0.00.00.10.30.0-0.2-0.2-0.20.2-0.20.20.2-0.10.1-0.20.2
Short access day 1 total infusions1.01.12.4-0.61.01.3-1.1-1.11.1-1.11.11.11.0-1.0-1.5-0.2
Short access day 10 total infusions0.40.50.6-0.60.70.6-0.7-0.70.7-0.70.70.70.6-0.7-0.8-0.7
Short access total infusions0.60.61.6-0.40.80.8-0.8-0.80.8-0.80.80.80.7-0.8-1.30.0
Short access day 1 locomotion4.24.55.9-2.12.12.4-2.1-2.12.1-2.12.12.12.1-2.2-2.2-1.7
Short access day 10 total locomotion1.31.42.4-1.51.11.4-1.1-1.11.1-1.11.11.11.3-1.3-0.6-1.5
Short access total locomotion0.60.60.9-0.80.70.9-0.8-0.80.8-0.80.80.80.7-0.8-0.5-0.4
One hour access (0.3 mA shock)0.00.00.1-0.10.1-0.2-0.1-0.10.1-0.10.10.10.2-0.2-0.20.1
Compulsive drug intake0.50.51.40.5-0.5-0.50.70.7-0.70.7-0.7-0.7-0.60.61.01.2
One hour access (shock baseline)0.50.61.0-0.50.70.4-0.8-0.80.8-0.80.80.80.7-0.7-1.0-0.7
Social response proportion0.50.50.80.8-0.8-0.70.70.7-0.70.7-0.7-0.7-0.90.90.50.7
Social responses0.00.00.3-0.10.10.4-0.0-0.00.0-0.00.00.00.1-0.0-0.1-0.6
Social time0.10.10.50.0-0.1-0.2-0.2-0.20.2-0.20.20.2-0.00.10.7-0.7
Soleus weight0.00.10.90.1-0.3-0.10.30.3-0.30.3-0.3-0.3-0.30.10.4-0.9
Bone: stiffness0.00.00.10.2-0.20.2-0.1-0.10.1-0.10.10.1-0.20.1-0.3-0.3
Tibialis anterior weight1.65.46.32.5-2.3-2.22.52.5-2.52.5-2.5-2.5-2.32.22.01.8
Time to tail flick, vehicle, before self-admin0.10.10.6-0.40.20.6-0.2-0.20.2-0.20.20.2-0.10.00.8-0.4
Time to tail flick, vehicle, after self-admin0.10.10.4-0.40.1-0.0-0.2-0.20.2-0.20.20.20.3-0.30.2-0.6
Time to tail flick, test, before self-admin1.00.91.51.2-1.2-1.10.80.8-0.80.8-0.8-0.8-1.01.11.21.0
Time to tail flick, test, after self-admin0.10.10.5-0.50.40.7-0.1-0.10.1-0.10.10.10.00.10.6-0.7
Delta time to tail flick, vehicle, before/after SA0.40.41.4-0.60.40.1-0.5-0.50.5-0.50.50.50.7-0.6-0.4-1.2
Delta time to tail flick, test, before/after SA1.51.42.6-1.61.61.5-1.0-1.01.0-1.01.01.01.2-1.0-0.8-1.4
Tibia length1.64.55.82.4-2.1-2.12.22.2-2.22.2-2.2-2.2-2.32.22.11.4
Ambulatory time before self-admin0.00.00.10.10.0-0.00.10.1-0.10.1-0.1-0.1-0.20.00.20.1
Ambulatory time after self-admin3.03.34.81.7-1.5-0.72.22.2-2.22.2-2.2-2.2-1.61.41.51.2
Bone: tissue strength1.21.12.00.8-1.1-1.01.11.1-1.11.1-1.1-1.1-1.11.01.40.6
Total heroin consumption3.03.56.3-1.92.01.4-1.9-1.91.9-1.91.91.91.6-1.7-1.5-2.5
Bone: trabecular number5.78.99.3-2.82.92.9-3.0-3.03.0-3.03.03.02.9-2.9-3.0-3.0
Bone: trabecular spacing1.51.92.91.5-1.3-1.41.31.3-1.31.3-1.3-1.3-1.51.51.70.9
Bone: trabecular thickness0.20.20.3-0.50.60.5-0.4-0.40.4-0.40.40.40.3-0.3-0.2-0.6
Bone: trabecular tissue density0.10.10.80.1-0.2-0.30.20.2-0.20.2-0.2-0.2-0.20.10.00.9
Water consumed over 24 hours0.10.10.30.1-0.1-0.1-0.1-0.10.1-0.10.10.1-0.50.40.6-0.1
Number of responses in last shaping day0.60.60.9-0.60.90.8-0.8-0.80.8-0.80.80.80.8-0.9-0.90.0