Hub : Genes

Rapgefl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Rapgefl1 0.12 0.07 5.5e-05 0.11 0.08 0.1 0.09 2.6e-06 5.5e-05 4.5e-06 1.1e-05
2 NAcc mRNA stability Rapgefl1 0.08 0.06 5.8e-10 0.05 0.06 0.07 0.07 9.3e-08 1.2e-09 1.9e-10 1.5e-10
3 IC gene expression Rapgefl1 0.13 0.08 4.7e-06 0.06 0.1 0.06 0.07 2.0e-03 7.2e-05 2.0e-03 7.4e-04
4 IC mRNA stability Rapgefl1 0.15 0.09 6.8e-06 0.07 0.06 0.08 0.06 8.6e-04 1.4e-03 3.7e-04 1.1e-03
5 IC intron excision ratio chr10_84293638_84294928 0.11 0.1 5.7e-04 0.04 0.06 0.04 0.03 7.7e-03 2.2e-03 7.4e-03 1.6e-02
6 PL mRNA stability Rapgefl1 0.31 0.14 0.0e+00 0.2 0.17 0.18 0.18 4.9e-21 1.9e-18 4.0e-19 1.4e-19
7 OFC gene expression Rapgefl1 0.18 0.12 2.9e-03 0.08 0.05 0.03 0.03 6.1e-03 2.6e-02 6.6e-02 5.6e-02
8 OFC mRNA stability Rapgefl1 0.18 0.12 1.9e-03 0.05 0.01 0.03 0.04 2.9e-02 1.7e-01 5.6e-02 3.9e-02
9 BLA mRNA stability Rapgefl1 0.35 0.18 8.7e-10 0.14 0.14 0.13 0.14 5.7e-08 7.3e-08 2.6e-07 7.5e-08
10 IL gene expression Rapgefl1 0.24 0.14 3.0e-04 0.16 0.09 0.16 0.16 1.1e-04 3.4e-03 8.8e-05 1.4e-04
11 Brain gene expression Rapgefl1 0.16 0.07 0.0e+00 0.23 0.23 0.22 0.23 6.8e-21 4.2e-21 2.0e-20 1.8e-21
12 PL gene expression Rapgefl1 0.12 0.06 5.8e-14 0.13 0.12 0.13 0.12 5.4e-14 8.0e-13 1.1e-13 1.6e-13
13 IC isoform ratio XM_039087397.2 0.06 0.05 6.6e-03 0.07 0.04 0.04 0.03 7.6e-04 9.7e-03 1.2e-02 1.8e-02
14 Brain mRNA stability Rapgefl1 0.07 0.04 2.1e-08 0.08 0.1 0.09 0.09 5.4e-08 1.6e-09 1.5e-08 1.3e-08
15 IL mRNA stability Rapgefl1 0.63 0.34 1.5e-05 0.14 0.23 0.14 0.14 3.9e-04 2.9e-06 2.8e-04 2.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density2.74.67.42.22.12.01.91.91.92.52.52.02.72.02.0-1.92.22.4
Area under the delay curve0.30.40.80.50.90.80.80.70.90.40.40.5-0.10.50.6-0.50.50.7
BMI with tail2.17.210.9-2.9-3.0-3.3-3.0-3.3-2.8-2.1-2.1-2.9-2.1-2.8-2.73.0-2.1-1.8
BMI without tail1.03.25.6-1.7-2.3-2.3-1.8-2.3-1.7-0.8-0.8-1.8-1.8-1.8-1.92.4-1.3-1.0
Body weight5.925.735.1-5.6-5.6-5.9-5.4-5.7-5.2-4.5-4.5-5.4-4.5-5.1-5.05.1-4.0-3.8
Weight adjusted by age0.20.30.7-0.60.1-0.4-0.7-0.3-0.8-0.8-0.8-0.60.6-0.2-0.00.00.30.3
Bone surface0.20.31.20.50.3-0.00.1-0.00.20.70.70.30.70.20.20.20.81.1
Bone volume0.30.62.30.80.60.20.40.20.50.90.90.71.20.60.50.11.21.5
Breakpoint value in progressive ratio session0.10.20.4-0.6-0.3-0.3-0.4-0.0-0.6-0.6-0.6-0.4-0.30.10.1-0.40.1-0.5
Number of licking bursts0.10.20.80.30.40.20.30.10.40.20.20.30.80.50.60.20.90.8
Context. condit. distance diff. score1.41.73.7-1.2-0.9-1.0-1.4-0.9-1.3-1.4-1.4-1.4-1.1-1.5-1.60.0-1.9-1.6
Locomotion velocity, session 10.50.61.7-0.8-0.6-0.9-0.7-0.8-0.5-0.5-0.5-0.6-1.3-0.7-0.71.1-0.4-0.2
Locomotion distance, session 12.12.65.7-1.4-2.0-2.0-1.7-1.9-1.5-0.8-0.8-1.5-2.1-1.6-1.62.4-1.0-0.8
Locomotion velocity, session 20.20.21.0-0.6-0.4-0.4-0.3-0.3-0.4-0.1-0.1-0.3-1.0-0.4-0.40.3-0.3-0.4
Locomotion distance, session 20.20.31.3-0.2-0.8-0.6-0.3-0.6-0.20.50.5-0.2-0.4-0.1-0.11.10.40.3
Locomotion velocity, session 30.10.10.50.1-0.10.20.10.2-0.10.60.60.10.70.10.1-0.70.0-0.3
Locomotion distance, session 30.20.20.5-0.5-0.7-0.5-0.6-0.6-0.5-0.1-0.1-0.7-0.2-0.4-0.30.5-0.3-0.5
Stereotopy head waving bouts, day 32.63.03.91.82.02.01.91.91.81.91.91.81.11.61.5-1.81.31.4
Stereotopy head waving duration, day 30.20.30.40.50.70.50.50.50.60.60.60.7-0.20.30.2-0.40.30.6
Locomotion velocity, session 71.01.12.1-1.1-1.0-1.2-1.1-1.3-0.9-1.4-1.4-1.0-0.4-1.1-0.81.3-0.5-0.6
Locomotion distance, session 70.60.71.7-0.7-0.9-0.9-0.7-0.9-0.5-1.1-1.1-0.7-1.0-0.8-0.61.3-0.5-0.6
Stereotopy head waving bouts, day 71.11.23.30.71.31.01.00.91.21.21.20.81.80.80.8-1.11.01.2
Stereotopy head waving duration, day 70.50.62.00.20.90.60.60.70.60.80.80.41.40.60.5-1.10.70.8
Locomotion velocity, session 87.89.310.7-3.1-3.0-3.1-3.2-3.0-3.0-2.9-2.9-3.1-3.3-3.2-3.22.6-3.2-2.8
Locomotion distance, session 81.31.82.3-1.3-1.5-1.5-1.5-1.4-1.4-1.1-1.1-1.4-1.5-1.5-1.51.3-1.2-1.0
Degree of sensitization distance1.31.32.7-1.0-1.1-1.1-1.0-1.1-0.8-1.5-1.5-0.8-1.7-1.2-1.11.3-1.1-1.0
Degree of sensitization stereotypy1.21.34.70.71.40.90.90.81.21.11.10.72.20.90.8-1.11.01.3
Conditioned locomotion0.30.31.00.30.60.60.60.70.50.30.30.40.80.50.5-1.00.40.3
Cocaine response after cond. corrected1.11.33.21.31.40.71.00.61.61.41.40.71.10.80.80.01.21.8
Cocaine response after cond. not corrected1.21.43.61.31.60.81.00.71.71.41.40.60.90.80.90.11.31.9
Cocaine response before conditioning0.00.00.20.20.50.20.10.20.2-0.0-0.00.1-0.30.00.1-0.10.10.1
Saline control response0.40.50.9-0.5-0.2-0.9-0.8-0.9-0.3-0.9-0.9-0.8-0.7-0.9-0.90.9-0.6-0.1
Bone: connectivity density3.86.08.42.62.32.42.32.32.22.92.92.32.72.32.3-2.12.42.5
Bone: cortical apparent density5.06.99.42.82.83.12.73.02.62.52.52.62.52.62.4-3.01.81.6
Bone: cortical area0.20.32.00.40.70.40.30.40.50.10.10.41.40.30.2-0.70.50.5
Bone: cortical porosity0.50.51.60.71.10.50.70.50.90.20.20.60.80.60.6-0.30.91.3
Bone: cortical porosity0.30.31.30.50.90.10.30.10.8-0.1-0.10.30.70.20.20.00.61.2
Bone: cortical thickness1.22.15.01.31.81.51.21.51.31.21.21.22.21.21.1-2.11.01.0
Bone: cortical thickness5.05.98.72.52.92.72.42.82.22.12.12.42.32.42.3-2.92.12.2
Bone: cortical tissue density5.06.89.42.82.83.12.83.02.62.52.52.62.42.62.5-2.91.91.7
Condit. Reinf. active minus inactive responses1.21.32.01.21.01.31.21.31.01.41.41.01.21.11.2-1.40.70.4
Condit. Reinf. active-inactive response ratio1.51.63.21.21.21.51.31.51.11.31.30.91.51.21.2-1.80.70.4
Condit. Reinf. active responses1.01.31.71.21.11.31.11.31.01.21.21.11.21.21.2-1.20.70.5
Condit. Reinf. inactive responses0.10.10.30.30.50.20.20.20.30.10.10.40.60.30.40.10.40.4
Incentive salience index mean2.22.73.41.81.61.71.71.71.61.91.91.61.61.71.7-1.51.41.1
Condit. Reinf. lever presses1.52.12.61.61.51.31.41.31.51.61.61.51.61.51.4-1.01.51.3
Condit. Reinf. active minus inactive responses0.81.12.01.00.91.11.01.10.70.70.71.30.91.31.4-0.81.41.0
Condit. Reinf. active-inactive response ratio0.80.91.81.00.70.90.90.90.70.80.81.30.71.21.3-0.51.31.0
Condit. Reinf. active responses1.41.93.31.41.21.31.31.31.11.01.01.61.31.71.8-0.91.81.4
Condit. Reinf. inactive responses1.51.92.61.51.51.31.41.31.51.21.21.31.21.51.5-0.81.61.6
Condit. Reinf. lever presses0.10.10.20.30.30.40.30.40.20.30.30.2-0.10.40.4-0.40.30.0
Condit. Reinf. lever reinforcers received1.62.23.31.51.31.51.41.51.21.21.21.61.41.71.8-1.21.81.4
Conditioned reinforcement - actives0.10.10.3-0.10.50.30.30.20.3-0.6-0.6-0.00.40.30.30.10.10.0
Conditioned reinforcement - inactives0.10.10.30.40.10.40.50.40.40.30.30.5-0.20.50.3-0.10.1-0.0
Conditioned locomotion0.50.72.10.60.70.90.90.71.00.50.50.61.50.81.0-0.11.00.7
Patch foraging indifference point 0 sec1.62.94.21.81.71.91.91.72.01.71.71.62.01.61.6-1.61.41.1
Patch foraging indifference point AUC0.00.00.20.00.3-0.10.1-0.10.40.00.0-0.10.4-0.2-0.1-0.10.00.4
Delay disc. indifference point, 0s delay1.92.13.81.41.41.51.51.41.60.90.91.52.01.41.4-1.61.41.4
Delay disc. indifference point, 16s delay0.40.51.40.61.10.80.60.90.70.40.40.5-1.20.10.2-0.8-0.20.4
Delay disc. indifference point, 2s delay1.21.32.21.11.31.11.10.91.51.01.01.21.51.01.1-0.41.31.5
Delay disc. indifference point, 24s delay0.20.32.1-0.4-0.1-0.2-0.1-0.30.0-0.4-0.4-0.6-1.4-0.4-0.40.5-0.6-0.4
Delay disc. indifference point, 4s delay1.01.01.91.01.41.21.01.20.90.40.41.00.51.01.1-1.11.11.2
Delay disc. indifference point, 8s delay0.10.10.3-0.00.40.40.50.30.60.20.20.10.10.20.3-0.10.30.4
Indifference point function ln k0.00.10.2-0.1-0.00.2-0.00.1-0.20.20.2-0.1-0.2-0.2-0.2-0.3-0.4-0.5
Indifference point function log k0.00.10.2-0.1-0.00.2-0.00.1-0.20.20.2-0.1-0.2-0.2-0.2-0.3-0.4-0.5
Patch foraging total patch changes 0 sec1.01.93.11.51.41.51.61.31.81.41.41.31.81.21.3-1.21.10.8
Patch foraging total patch changes 12 sec4.76.07.92.42.52.52.52.42.62.12.12.52.62.52.6-1.92.82.6
Patch foraging total patch changes 18 sec0.40.62.90.60.80.60.80.50.90.40.40.61.70.60.7-0.60.70.4
Patch foraging total patch changes 24 sec0.91.53.11.11.51.21.11.21.21.01.00.81.81.01.2-1.31.21.3
Patch foraging total patch changes 6 sec1.82.83.91.71.71.61.81.52.01.81.81.72.01.61.4-1.41.51.4
Patch foraging time to switch 0 sec0.00.10.20.40.10.20.30.30.20.20.20.30.40.50.3-0.10.50.4
Patch foraging water rate 0 sec0.10.20.50.40.20.40.40.40.20.70.70.40.20.30.4-0.50.2-0.0
Patch foraging water rate 12 sec0.20.31.0-0.8-0.2-0.2-0.40.0-0.9-1.0-1.0-0.4-0.6-0.1-0.1-0.4-0.2-0.6
Patch foraging water rate 18 sec0.50.81.60.71.10.80.70.80.41.01.00.60.60.81.0-0.91.31.2
Patch foraging water rate 24 sec0.50.71.71.10.60.80.80.80.51.11.11.30.00.80.8-0.60.80.7
Patch foraging water rate 6 sec1.62.33.21.61.51.61.51.71.21.81.81.50.61.61.8-1.61.61.2
Seeking ratio, delayed vs. immediate footshock0.20.20.80.30.20.2-0.20.4-0.3-0.6-0.60.2-0.20.1-0.0-0.8-0.7-0.9
Distance traveled before self-admin0.10.20.50.20.50.10.10.3-0.0-0.5-0.50.5-0.70.50.4-0.10.50.4
Distance traveled after self-admin0.40.51.4-1.0-0.8-0.8-0.7-0.7-0.8-0.4-0.4-0.4-1.2-0.6-0.70.7-0.6-0.5
Extensor digitorum longus weight9.637.642.5-6.5-6.2-6.3-6.3-6.2-6.1-6.3-6.3-6.2-5.6-6.2-6.25.2-6.1-6.0
Bone: elastic displacement0.00.00.20.1-0.4-0.10.0-0.20.20.00.0-0.00.3-0.1-0.20.4-0.2-0.2
Bone: elastic work0.10.20.70.40.30.20.20.20.40.40.40.40.90.30.2-0.30.50.7
Bone: endosteal estimation2.04.37.6-2.2-2.2-2.5-2.0-2.5-1.8-2.2-2.2-1.9-1.8-2.0-2.02.8-1.2-0.9
Bone: endosteal perimeter1.32.83.8-1.7-2.0-2.0-1.7-2.0-1.7-1.9-1.9-1.4-1.4-1.6-1.61.9-1.2-1.2
Epididymis fat weight0.10.30.6-0.7-0.4-0.8-0.7-0.7-0.6-0.7-0.7-0.6-0.3-0.5-0.50.7-0.2-0.1
Delta time in closed arm before/after self-admin4.03.75.0-2.0-2.2-2.2-2.2-2.1-2.0-1.2-1.2-2.1-1.8-2.2-2.21.6-1.9-1.6
Delta time in open arm before/after self-admin0.10.10.6-0.10.20.0-0.10.1-0.1-0.1-0.1-0.2-0.8-0.0-0.2-0.1-0.4-0.2
Diff in mean of infusions in LGA sessions0.10.10.6-0.2-0.30.0-0.20.1-0.40.10.1-0.00.80.30.3-0.50.4-0.0
Delay discount exponential model param0.20.20.5-0.4-0.7-0.6-0.6-0.6-0.7-0.4-0.4-0.30.4-0.3-0.40.3-0.3-0.5
Extinction: sum of active levers before priming1.21.42.4-1.3-0.9-1.4-1.2-1.4-0.8-0.9-0.9-1.6-1.0-1.4-1.41.1-1.1-0.7
Active lever presses in extinction session 60.90.93.00.70.90.30.70.41.00.50.50.61.50.70.7-0.51.51.7
Bone: final force0.81.33.51.01.30.71.00.61.30.80.80.91.90.90.8-0.61.41.8
Bone: final moment0.61.03.20.81.10.50.80.41.20.70.70.81.80.70.6-0.51.21.7
Food consumed during 24 hour testing period0.91.22.2-1.2-1.2-1.0-1.1-1.1-1.2-1.3-1.3-0.8-1.5-0.9-1.11.1-0.8-0.8
Glucose0.10.20.90.30.5-0.10.2-0.21.00.20.20.1-0.1-0.2-0.20.50.30.9
Heart weight3.25.06.5-2.2-2.2-2.5-2.4-2.4-2.0-2.1-2.1-2.1-2.4-2.2-2.62.2-2.1-1.9
Delay discount hyperbolic model param0.20.20.5-0.4-0.7-0.6-0.5-0.5-0.6-0.3-0.3-0.30.2-0.3-0.40.3-0.3-0.5
Intermittent access intake day 1-15 change0.10.20.6-0.0-0.10.30.00.4-0.50.60.60.1-0.80.30.5-0.60.30.0
Intermittent access intake escalation0.10.20.7-0.1-0.10.2-0.10.4-0.60.70.70.1-0.90.30.4-0.50.20.0
Intermittent access intake escalation 20.40.41.7-0.6-0.8-0.5-0.6-0.5-1.10.30.3-0.5-1.3-0.4-0.30.4-0.3-0.4
Intermitt. access day 1 inactive lever presses0.62.54.51.81.31.51.41.81.12.12.11.60.21.51.5-1.91.41.2
Intermitt. access day 15 inactive lever presses1.12.34.21.51.01.71.61.61.52.02.01.50.81.61.6-1.61.00.6
Intermitt. access escalation Index1.62.23.8-1.8-1.1-1.4-1.8-1.4-2.0-1.8-1.8-1.7-1.3-1.5-1.50.7-1.1-0.8
Intermittent access day 1 total infusions0.10.10.5-0.20.30.10.10.20.1-0.7-0.70.3-0.10.1-0.10.0-0.10.0
Intermittent access day 15 total infusions0.10.11.4-0.30.10.1-0.10.3-0.4-0.1-0.10.1-1.20.10.0-0.4-0.2-0.1
Intermittent access terminal intake (last 3 days)0.10.20.90.10.30.40.30.60.10.40.40.5-0.90.40.3-0.50.10.2
Intermittent access total infusions0.10.11.2-0.30.20.10.10.3-0.1-0.5-0.50.2-1.10.1-0.0-0.2-0.3-0.2
Intermittent access day 1 locomotion0.10.10.40.20.30.20.40.10.6-0.3-0.30.40.40.10.00.2-0.00.1
Intermittent access day 15 total locomotion0.20.30.70.70.40.50.60.40.80.40.40.70.80.40.50.30.60.6
Intermittent access total locomotion0.70.81.60.91.11.01.10.91.30.50.51.10.80.91.0-0.50.70.7
Intermittent access standard deviation0.81.62.51.10.91.41.31.60.81.41.41.5-0.11.51.6-1.51.10.7
Left kidney weight0.41.74.3-1.4-1.5-1.4-1.5-1.1-2.1-1.3-1.3-1.1-1.2-1.1-1.40.1-1.1-1.2
Right kidney weight0.00.10.5-0.1-0.3-0.3-0.3-0.1-0.70.10.10.1-0.30.10.0-0.10.50.6
Cocaine induced anxiety2.13.14.8-1.8-2.2-2.0-1.9-1.9-1.8-1.3-1.3-2.0-1.6-1.9-1.71.5-1.5-1.4
Post-drug Anxiety0.70.71.3-0.8-0.9-0.9-1.0-0.9-1.1-0.6-0.6-1.1-0.6-0.9-0.80.5-1.0-1.0
Baseline Anxiety1.51.74.11.42.01.61.31.41.10.60.61.31.81.31.4-1.01.00.9
Tail length0.41.83.1-1.4-1.5-1.4-1.2-1.1-1.3-1.3-1.3-1.4-1.8-1.2-1.21.0-1.2-1.4
Length with tail2.29.812.4-3.5-3.5-3.4-3.3-3.1-3.5-3.2-3.2-3.4-3.0-2.9-2.82.5-2.5-2.7
Length without tail2.89.011.2-3.3-3.1-3.3-3.2-3.2-3.1-3.2-3.2-3.2-2.3-3.0-2.82.7-2.3-2.4
Times rat made contact with spout0.70.81.40.80.70.81.00.71.10.80.81.20.91.10.8-0.31.01.0
Lifetime Intake0.10.20.7-0.00.50.40.30.60.1-0.2-0.20.4-0.80.40.2-0.5-0.1-0.0
Liver weight, left0.20.41.1-0.5-0.4-0.8-0.7-0.8-0.6-0.4-0.4-0.7-0.5-0.7-0.61.0-0.2-0.1
Liver weight, right0.50.81.51.01.10.80.90.91.11.21.20.80.40.40.5-0.90.61.2
Locomotor activity0.50.82.10.81.10.70.80.70.80.70.70.70.90.91.0-0.31.41.4
Locomotor testing distance1.93.44.42.02.11.91.81.81.71.71.71.72.01.82.0-1.62.01.9
Locomotor testing rearing4.99.913.23.63.43.43.43.33.33.33.33.22.72.93.0-3.12.72.5
Locomotion in novel chamber4.86.19.82.93.12.62.62.62.91.61.62.82.12.52.4-2.02.32.4
Locomotion in novel chamber post-restriction0.40.61.10.90.50.50.70.40.70.80.80.81.01.00.8-0.11.00.8
Fecal boli incidents, locomotor time 10.20.41.5-0.5-0.7-0.7-0.4-0.7-0.1-0.4-0.4-0.4-0.2-0.6-0.61.2-0.6-0.6
Change in fecal boli incidents, locomotor task0.10.10.3-0.00.40.30.20.30.30.00.00.1-0.30.10.1-0.30.30.5
Time >=10cm from walls, locomotor time 10.50.54.10.50.80.60.50.50.8-0.1-0.10.12.00.30.3-1.00.00.0
Bouts of movement, locomotor time 10.30.41.1-0.7-0.6-0.7-0.7-0.7-1.0-0.3-0.3-0.80.0-0.6-0.40.5-0.4-0.6
Total resting periods, locomotor time 10.80.91.6-1.1-0.9-1.1-1.0-1.1-1.3-0.6-0.6-1.1-0.5-1.0-0.71.2-0.6-0.8
Rest time, locomotor task time 10.10.20.6-0.3-0.3-0.20.0-0.2-0.20.80.80.2-0.40.10.00.80.40.2
Distance moved, locomotor task time 10.10.10.40.60.70.1-0.00.30.3-0.5-0.50.10.3-0.1-0.1-0.5-0.30.2
Vertical activity count, locomotor time 10.20.51.8-0.3-0.1-0.5-0.6-0.4-0.2-1.4-1.4-0.7-0.7-0.6-0.50.5-0.6-0.4
Time >=10cm from walls, locomotor time 21.01.45.60.81.71.11.01.11.3-0.5-0.50.72.41.01.1-1.21.31.2
Bouts of movement, locomotor time 20.40.62.40.90.70.80.70.90.30.50.50.41.40.60.7-1.60.70.2
Total resting periods, locomotor time 20.20.42.10.60.50.60.40.70.00.40.40.21.10.50.5-1.50.4-0.0
Rest time, locomotor task time 20.60.81.7-1.3-1.0-1.0-1.0-1.0-0.8-0.7-0.7-1.0-0.6-0.8-0.81.0-0.7-0.8
Distance moved, locomotor task time 20.10.10.40.30.2-0.4-0.2-0.40.3-0.1-0.1-0.20.2-0.5-0.60.4-0.30.3
Vertical activity count, locomotor time 20.30.51.1-0.4-0.4-0.6-0.6-0.7-0.2-0.6-0.6-0.7-1.1-0.8-0.81.0-0.8-0.5
Light reinforcement 11.94.85.32.12.02.22.22.22.02.22.22.32.32.22.3-2.12.32.0
Light reinforcement 20.71.12.51.30.80.60.90.61.21.61.61.00.50.70.7-0.11.11.6
Bone: marrow area1.94.17.2-2.1-2.2-2.5-2.0-2.5-1.7-2.1-2.1-1.9-1.8-2.0-2.02.7-1.2-0.9
Bone: maximum diameter0.10.10.80.10.30.10.10.10.0-0.2-0.20.30.90.20.3-0.20.50.4
Bone: maximum force0.00.10.4-0.20.1-0.4-0.2-0.40.1-0.1-0.1-0.20.4-0.3-0.30.20.30.6
Bone: maximum moment0.10.10.3-0.4-0.0-0.5-0.4-0.5-0.1-0.2-0.2-0.30.3-0.4-0.50.30.10.5
Mean time between licks in bursts0.92.13.6-1.5-1.9-1.7-1.5-1.8-1.5-1.1-1.1-1.4-0.8-1.4-1.51.6-1.2-1.4
Mean num. licks in bursts0.10.10.30.30.10.40.40.40.40.40.40.5-0.30.20.1-0.4-0.2-0.0
Cd content in liver1.51.72.6-1.4-1.6-1.4-1.3-1.4-1.3-1.0-1.0-1.2-1.1-1.2-1.31.5-1.4-1.3
Co content in liver2.02.33.6-1.4-1.8-1.4-1.6-1.4-1.7-1.3-1.3-1.5-1.4-1.5-1.61.1-1.9-1.9
Cu content in liver0.20.21.00.30.10.30.20.50.00.40.40.10.90.20.2-1.0-0.2-0.5
Fe content in liver1.51.83.0-1.2-1.3-1.6-1.4-1.6-1.0-1.3-1.3-1.3-1.4-1.4-1.51.7-1.0-0.7
K content in liver1.21.23.50.81.51.21.01.40.80.50.50.80.91.01.1-1.91.00.9
Mg content in liver0.90.94.20.71.41.31.01.40.70.40.40.60.60.70.8-2.10.30.2
Mn content in liver1.21.43.31.01.31.51.31.61.00.90.91.01.01.11.2-1.80.80.5
Na content in liver0.40.41.90.40.90.30.50.40.60.30.30.50.60.60.7-0.31.11.4
Rb content in liver1.72.04.31.71.51.51.71.32.11.71.71.31.11.21.1-1.00.91.0
Se content in liver7.48.811.72.83.33.33.13.42.82.82.82.92.53.03.1-3.32.62.3
Sr content in liver0.40.31.1-0.7-0.5-0.0-0.40.1-0.7-0.8-0.8-0.4-0.4-0.3-0.2-0.6-0.6-1.1
Zn content in liver3.74.15.42.22.12.22.02.31.72.22.22.22.02.02.0-2.31.61.5
Bone: minimum diameter0.40.71.2-0.9-0.5-1.1-0.9-1.1-0.5-1.0-1.0-0.8-0.0-0.9-1.00.8-0.6-0.3
Time in familiar zone, hab. session 10.40.41.70.70.50.00.30.00.50.30.30.4-1.10.30.30.80.91.3
Time in novel zone, hab. session 10.70.72.70.50.51.00.80.90.81.01.00.41.60.60.6-1.3-0.1-0.5
Total zone transitions, hab. session 11.92.74.7-1.4-1.7-1.6-1.8-1.5-1.7-1.5-1.5-1.5-2.2-1.7-1.61.6-1.7-1.5
Total locomotion distance, hab. session 10.10.11.20.0-0.30.0-0.30.1-0.4-0.0-0.0-0.1-1.1-0.1-0.20.1-0.4-0.4
Locomotion velocity, hab. session 10.40.61.9-0.7-0.7-0.5-0.9-0.4-1.1-0.8-0.8-0.6-1.4-0.5-0.50.4-0.6-0.7
Time in familiar zone, hab. session 20.60.61.51.00.90.70.70.70.90.90.90.50.10.70.7-0.40.91.2
Time in novel zone, hab. session 20.20.20.80.20.10.40.40.40.20.40.40.40.90.40.4-0.60.2-0.3
Total zone transitions, hab. session 21.01.22.9-0.8-1.1-1.3-1.1-1.4-0.7-0.6-0.6-1.3-0.8-1.3-1.31.7-1.1-0.8
Total locomotion distance, hab. session 20.30.41.7-0.3-0.9-0.7-0.7-0.8-0.5-0.1-0.1-0.6-0.6-0.5-0.61.3-0.4-0.3
Locomotion velocity, hab. session 20.50.72.0-0.6-1.1-0.9-1.0-1.0-0.8-0.5-0.5-0.9-0.9-0.7-0.81.4-0.6-0.5
Novel to familiar place preference ratio1.31.43.0-1.5-0.9-0.8-1.1-0.7-1.5-1.7-1.7-1.1-1.0-1.0-0.90.0-1.1-1.3
Novelty place preference1.21.33.0-1.5-0.8-0.7-1.0-0.6-1.4-1.7-1.7-1.1-1.0-0.9-0.8-0.1-1.1-1.3
Time in novel zone, NPP test0.60.61.7-1.1-0.4-0.3-0.6-0.2-1.0-1.3-1.3-0.8-0.6-0.6-0.5-0.4-0.8-0.9
Total zone transitions, NPP test0.60.84.2-0.3-0.9-1.2-0.9-1.3-0.4-0.4-0.4-0.8-0.8-1.0-0.92.0-0.40.0
Total locomotion distance, NPP test0.20.21.80.3-0.4-0.4-0.3-0.50.10.50.5-0.1-0.5-0.2-0.31.30.20.5
Locomotion velocity, NPP test0.50.72.9-0.3-1.0-0.9-0.8-1.0-0.6-0.2-0.2-0.3-1.2-0.6-0.91.7-0.4-0.1
Intraocular pressure3.34.88.0-2.0-2.3-2.3-2.1-2.4-2.1-1.9-1.9-1.8-2.2-2.2-2.12.8-2.4-2.1
Delta distance traveled before/after self-admin1.21.32.2-1.5-1.3-1.1-1.2-1.2-1.1-0.7-0.7-1.3-0.8-1.3-1.31.0-1.4-1.1
Delta ambulatory time before/after self-admin1.21.52.9-1.7-1.4-1.3-1.2-1.5-1.0-0.4-0.4-1.5-0.6-1.5-1.41.4-1.2-0.8
Parametrial fat weight0.51.12.41.10.70.81.00.80.81.11.10.90.91.31.3-0.41.51.4
Pavlov. Cond. lever latency2.63.24.9-2.0-1.7-1.4-1.8-1.3-2.0-2.1-2.1-1.8-1.5-1.8-1.80.5-2.1-2.2
Pavlov. Cond. magazine entry latency10.113.015.13.93.83.63.63.53.53.53.53.83.53.73.6-2.83.73.8
Pavlov. Cond. change in total contacts9.610.212.43.53.43.43.33.43.23.33.33.32.83.33.1-3.22.72.6
Pavlov. Cond. index score8.610.912.93.63.43.13.43.03.53.43.43.53.03.43.3-2.13.53.5
Pavlov. Cond. latency score6.78.510.73.23.02.72.92.63.13.13.13.12.63.02.9-1.73.13.3
Pavlov. Cond. lever contacts3.33.95.42.21.91.72.01.62.12.22.22.11.72.12.0-0.72.32.3
Pavlov. Cond. magazine entry number12.916.318.9-4.3-4.3-4.1-4.2-4.0-4.2-4.1-4.1-4.3-3.9-4.1-3.93.3-3.9-4.0
Pavlov. Cond. intertrial magazine entries1.31.62.5-1.4-1.3-1.2-1.1-1.1-1.0-1.1-1.1-1.5-1.2-1.3-1.21.0-1.5-1.6
Pavlov. Cond. lever-magazine prob. diff.10.212.615.13.93.73.43.63.33.73.73.73.83.13.73.6-2.43.73.7
Pavlov. Cond. response bias10.613.215.03.93.93.63.73.53.73.73.73.83.43.73.6-2.93.63.6
Pavlov. Cond. lever latency0.40.51.0-0.8-0.6-0.7-0.7-0.7-0.5-0.5-0.5-0.8-0.4-0.9-0.90.4-1.0-0.7
Pavlov. Cond. magazine entry latency0.10.10.4-0.3-0.2-0.3-0.5-0.3-0.5-0.5-0.5-0.2-0.6-0.1-0.10.6-0.1-0.2
Pavlov. Cond. change in total contacts0.40.71.21.10.91.00.91.00.80.70.71.10.11.00.9-0.50.80.4
Pavlov. Cond. index score0.10.10.30.50.30.30.30.20.20.30.30.5-0.20.50.50.30.50.4
Pavlov. Cond. latency score0.10.10.20.40.20.20.20.10.10.20.20.4-0.20.40.40.40.40.3
Pavlov. Cond. lever contacts0.40.51.10.90.70.70.70.60.60.60.60.90.30.90.9-0.21.00.9
Pavlov. Cond. magazine entry number0.10.10.2-0.4-0.4-0.2-0.1-0.2-0.2-0.4-0.4-0.3-0.1-0.3-0.3-0.1-0.3-0.3
Pavlov. Cond. intertrial magazine entries1.52.33.7-1.8-1.5-1.1-1.5-1.1-1.8-1.8-1.8-1.5-1.0-1.5-1.30.4-1.7-1.9
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.40.10.10.10.10.10.20.20.4-0.30.30.30.40.40.2
Pavlov. Cond. response bias0.81.11.81.21.11.01.01.00.90.90.91.20.71.31.2-0.61.31.1
Time in closed arm before self-admin2.02.55.01.81.51.71.71.61.52.22.21.80.71.41.3-1.31.11.0
Time in closed arm after self-admin0.20.20.8-0.2-0.2-0.1-0.30.0-0.40.30.3-0.0-0.9-0.5-0.4-0.4-0.7-0.6
Time in open arm before self-admin1.71.95.4-1.8-0.9-1.3-1.4-1.2-1.2-2.3-2.3-1.50.2-1.1-1.00.7-0.8-0.8
Time in open arm after self-admin0.40.40.9-0.8-0.3-0.5-0.6-0.5-0.5-1.0-1.0-0.9-0.5-0.4-0.40.4-0.5-0.5
Bone: periosteal estimation0.20.50.9-0.7-0.5-0.9-0.7-1.0-0.5-0.9-0.9-0.6-0.1-0.6-0.71.0-0.10.1
Bone: periosteal perimeter0.61.11.9-1.0-1.1-1.4-1.2-1.4-1.1-1.1-1.1-0.8-0.4-1.0-1.11.3-0.5-0.4
Bone: post-yield work1.11.62.1-1.3-1.3-1.4-1.4-1.4-1.4-0.8-0.8-1.2-1.3-1.3-1.41.0-1.1-1.1
Progressive ratio test 1 active lever presses0.10.10.50.00.70.30.40.30.6-0.3-0.30.20.30.20.1-0.10.10.3
Progressive ratio test 1 breakpoint0.10.10.3-0.10.60.20.30.20.5-0.4-0.40.10.20.10.0-0.1-0.00.2
Progressive ratio test 1 inactive lever presses0.20.30.70.40.60.50.50.70.40.50.50.50.10.60.5-0.80.30.2
Progressive ratio test 2 active lever presses0.70.81.30.81.11.01.11.11.00.20.21.10.41.11.1-0.70.80.6
Progressive ratio test 2 breakpoint0.80.91.40.81.21.11.11.11.10.20.21.10.51.11.1-0.70.90.7
Progressive ratio test 2 inactive lever presses0.10.10.30.30.20.40.40.50.50.00.00.5-0.30.50.4-0.20.20.1
Incentive Sensitization - Responses1.01.32.31.31.01.31.41.31.30.50.51.50.71.51.4-0.61.30.9
Incentive Sensitization - Breakpoint0.91.22.21.21.01.21.31.21.20.50.51.50.61.41.4-0.61.30.9
Sum of active levers in priming session hrs 5-60.20.20.70.00.80.20.40.30.80.30.30.20.30.10.1-0.40.40.9
Progressive ratio0.10.10.30.50.50.20.30.40.5-0.1-0.10.1-0.00.40.5-0.20.60.5
Food seeking constrained by brief footshock0.50.61.10.60.60.60.80.60.91.11.10.60.60.90.7-0.41.01.1
Seeking ratio, punishment vs. effort0.00.00.1-0.2-0.3-0.0-0.1-0.2-0.20.40.40.00.1-0.1-0.30.0-0.3-0.0
Retroperitoneal fat weight0.10.30.60.70.20.40.60.40.80.70.70.50.20.50.4-0.20.60.6
Reaction time number correct0.81.53.8-1.1-1.0-1.2-1.3-1.1-1.3-2.0-2.0-0.8-1.3-0.9-1.11.0-0.7-0.8
Reaction time mean minus median0.20.51.2-0.7-1.1-0.7-0.8-0.8-0.80.00.0-0.9-0.2-0.7-0.50.9-0.8-1.0
Reaction time mean minus median AUC0.00.10.2-0.0-0.3-0.1-0.2-0.3-0.10.50.5-0.30.3-0.2-0.10.3-0.3-0.3
Reaction time num false alarms0.50.71.90.81.10.60.70.50.90.50.50.90.50.70.90.11.21.4
Reaction time num false alarms AUC0.30.51.40.60.70.50.50.40.60.40.40.70.50.70.90.21.21.2
Reaction time trials correct on left0.81.53.8-1.1-1.0-1.2-1.3-1.1-1.3-2.0-2.0-0.8-1.3-0.9-1.11.0-0.7-0.8
Reaction time trials on left0.71.43.6-1.0-1.0-1.1-1.3-1.1-1.2-1.9-1.9-0.8-1.3-0.9-1.00.9-0.7-0.8
Reaction time mean0.20.30.90.40.20.70.40.80.00.80.80.20.20.60.7-1.00.1-0.2
Reaction time mean AUC0.20.31.10.40.30.70.40.80.00.80.80.20.30.60.7-1.10.1-0.2
Median of all reaction times0.81.22.71.00.91.41.11.50.61.11.10.90.51.21.4-1.60.70.4
Reaction time omissions0.40.61.30.90.40.80.50.80.31.11.10.80.80.80.9-0.70.70.5
Reaction time false alarm rate1.01.32.21.11.21.01.10.91.11.31.31.11.01.11.3-0.41.41.5
Reaction time premature initiation rate0.40.51.40.10.90.80.50.90.20.30.30.30.60.80.9-1.20.80.8
Reaction time premature initiations0.10.31.0-0.80.0-0.1-0.50.0-0.7-1.0-1.0-0.4-0.4-0.0-0.0-0.40.10.1
Std. dev. reaction times0.10.10.40.0-0.4-0.0-0.2-0.1-0.30.60.6-0.30.30.00.10.1-0.2-0.4
Reaction time trials completed0.71.43.6-1.0-1.0-1.1-1.3-1.1-1.2-1.9-1.9-0.8-1.3-0.9-1.00.9-0.7-0.8
Reaction time trials AUC0.71.43.7-1.0-0.9-1.1-1.3-1.0-1.2-1.9-1.9-0.8-1.2-0.8-1.00.9-0.7-0.8
Run reversals in cocaine runway, females2.02.03.3-1.7-1.0-1.1-1.4-0.9-1.3-1.8-1.8-1.4-1.4-1.4-1.50.3-1.8-1.5
Run reversals in cocaine runway, males0.20.20.50.60.30.50.50.40.7-0.0-0.00.5-0.30.40.3-0.20.20.4
Latency to leave start box in cocaine runway1.41.62.4-0.9-1.3-1.3-1.3-1.1-1.3-1.5-1.5-0.8-1.5-1.2-1.40.7-1.3-1.4
Latency to leave start box in cocaine runway, F2.42.85.6-1.5-1.3-1.5-1.7-1.4-1.8-2.4-2.4-1.2-2.3-1.4-1.60.9-1.6-1.5
Latency to leave start box in cocaine runway, M0.30.30.70.8-0.00.30.40.40.50.80.80.50.80.30.2-0.50.1-0.1
Std. dev. time between licks in bursts0.10.10.3-0.3-0.6-0.4-0.3-0.4-0.50.00.0-0.20.5-0.1-0.10.40.2-0.1
Total sessions with >9 infusions0.20.20.50.30.70.50.40.70.30.20.20.4-0.50.30.2-0.7-0.2-0.1
Short access day 1 total inactive lever presses1.62.03.61.81.11.51.31.61.11.91.91.80.81.51.2-1.21.01.2
Short access day 10 total inactive lever presses0.10.10.6-0.1-0.8-0.0-0.20.0-0.50.50.5-0.2-0.60.20.2-0.2-0.0-0.5
Short access day 1 total infusions0.40.51.30.81.00.80.81.00.80.50.50.8-0.70.60.3-1.1-0.00.5
Short access day 10 total infusions0.30.31.00.41.00.70.60.80.60.20.20.9-0.00.60.5-0.60.40.5
Short access total infusions0.30.30.90.41.00.70.60.90.50.10.10.7-0.50.60.4-0.90.20.4
Short access day 1 locomotion1.11.42.21.31.21.21.31.31.41.51.51.30.41.00.8-1.20.81.1
Short access day 10 total locomotion1.12.13.81.71.21.41.71.21.91.41.41.71.61.31.3-0.51.41.4
Short access total locomotion0.30.30.90.80.50.60.80.50.90.60.60.80.10.40.3-0.20.40.5
One hour access (0.3 mA shock)0.30.41.1-0.8-0.1-0.4-0.5-0.4-0.6-1.0-1.0-0.6-0.2-0.5-0.40.3-0.7-0.7
Compulsive drug intake0.20.31.5-0.40.1-0.1-0.2-0.1-0.0-0.4-0.4-0.5-0.0-0.4-0.3-0.3-1.2-1.1
One hour access (shock baseline)0.00.10.4-0.30.1-0.0-0.20.1-0.3-0.3-0.30.0-0.60.10.0-0.10.20.1
Social response proportion0.20.20.8-0.2-0.1-0.6-0.5-0.6-0.10.30.3-0.60.2-0.7-0.90.6-0.6-0.2
Social responses0.40.51.90.90.4-0.10.4-0.10.81.41.40.20.40.00.10.60.50.8
Social time0.10.21.20.4-0.5-0.5-0.3-0.6-0.10.10.1-0.20.5-0.1-0.01.10.40.5
Soleus weight0.10.31.5-0.20.1-0.50.0-0.60.50.40.4-0.30.2-0.1-0.21.20.61.1
Bone: stiffness0.00.10.4-0.20.5-0.1-0.10.00.0-0.3-0.30.0-0.2-0.1-0.1-0.20.30.7
Tibialis anterior weight1.55.06.5-2.3-2.2-2.5-2.5-2.5-2.3-2.0-2.0-2.4-2.3-2.3-2.32.3-2.0-1.5
Time to tail flick, vehicle, before self-admin0.20.31.00.5-0.6-0.10.1-0.30.01.01.00.30.70.10.00.70.20.1
Time to tail flick, vehicle, after self-admin0.10.10.4-0.10.20.10.1-0.00.0-0.4-0.4-0.10.50.30.50.20.60.3
Time to tail flick, test, before self-admin1.11.22.3-1.3-1.1-1.1-1.1-1.1-1.2-0.9-0.9-1.5-1.1-1.0-0.81.1-0.8-0.8
Time to tail flick, test, after self-admin0.30.31.20.6-0.2-0.10.4-0.20.71.11.10.4-0.20.20.20.70.50.6
Delta time to tail flick, vehicle, before/after SA0.50.41.40.10.90.40.60.40.7-0.5-0.50.30.60.70.9-0.21.21.0
Delta time to tail flick, test, before/after SA2.52.65.02.21.41.41.81.42.21.71.72.01.11.51.3-0.91.51.5
Tibia length1.43.86.1-1.8-1.8-2.4-2.2-2.5-1.7-1.8-1.8-2.0-1.5-2.1-2.32.3-1.6-0.9
Ambulatory time before self-admin0.10.10.8-0.00.10.00.00.2-0.2-0.4-0.40.4-0.90.30.2-0.20.2-0.1
Ambulatory time after self-admin1.51.84.8-1.6-1.6-1.5-1.3-1.4-1.4-0.6-0.6-1.0-2.2-1.2-1.31.5-1.0-0.8
Bone: tissue strength1.41.41.8-1.4-1.3-1.3-1.3-1.3-1.2-0.9-0.9-1.2-0.9-1.3-1.31.0-1.2-1.3
Total heroin consumption2.52.96.11.41.51.51.51.51.51.21.22.01.82.11.8-1.32.52.1
Bone: trabecular number6.09.912.63.33.22.93.02.93.03.43.43.13.53.03.0-2.53.33.6
Bone: trabecular spacing2.02.74.5-1.7-1.6-1.9-1.7-1.9-1.5-1.7-1.7-1.5-1.5-1.5-1.52.1-1.2-1.0
Bone: trabecular thickness0.20.20.60.70.00.20.20.20.10.60.60.30.80.30.3-0.30.40.4
Bone: trabecular tissue density0.10.21.0-0.3-0.10.2-0.00.20.0-0.2-0.2-0.6-0.3-0.3-0.3-0.6-0.8-1.0
Water consumed over 24 hours0.30.42.2-0.7-0.7-0.5-0.5-0.6-0.4-0.6-0.6-0.1-1.5-0.2-0.50.9-0.2-0.2
Number of responses in last shaping day0.30.30.80.50.10.50.50.60.40.90.90.5-0.40.40.3-0.6-0.2-0.2