Rapgefl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	Rapgefl1	0.07	0.04	8.0e-11	0.07	0.09	0.08	0.09	1.5e-08	1.5e-10	6.7e-10	2.7e-10
2	BLA	gene expression	Rapgefl1	0.1	0.06	8.1e-05	0.1	0.07	0.09	0.09	8.3e-06	8.5e-05	1.4e-05	1.2e-05
3	IL	gene expression	Rapgefl1	0.24	0.14	2.1e-04	0.22	0.1	0.18	0.18	5.5e-06	2.0e-03	4.7e-05	4.9e-05
4	OFC	mRNA stability	Rapgefl1	0.19	0.12	1.7e-03	0.06	0.01	0.03	0.04	1.9e-02	2.1e-01	8.3e-02	4.7e-02
5	Brain	gene expression	Rapgefl1	0.17	0.07	0.0e+00	0.24	0.23	0.18	0.22	1.6e-22	7.7e-21	1.6e-16	4.5e-20
6	PL	mRNA stability	Rapgefl1	0.28	0.14	0.0e+00	0.19	0.18	0.18	0.19	5.8e-21	6.8e-20	6.4e-20	8.6e-21
7	BLA	mRNA stability	Rapgefl1	0.37	0.18	2.5e-10	0.17	0.16	0.16	0.16	3.2e-09	9.1e-09	4.5e-09	4.5e-09
8	OFC	gene expression	Rapgefl1	0.19	0.12	2.9e-03	0.05	0.05	0.06	0.06	2.4e-02	2.4e-02	1.6e-02	1.9e-02
9	Brain	mRNA stability	Rapgefl1	0.07	0.04	7.5e-09	0.08	0.1	0.08	0.08	1.4e-07	2.3e-09	3.6e-08	5.9e-08
10	PL	gene expression	Rapgefl1	0.11	0.06	2.4e-13	0.11	0.12	0.11	0.12	3.4e-12	6.1e-13	2.0e-12	9.4e-13
11	IL	mRNA stability	Rapgefl1	0.54	0.32	1.8e-05	0.12	0.21	0.14	0.15	7.3e-04	9.6e-06	3.8e-04	1.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	2.6	4.3	5.4	2.1	-2.0	-2.1	-1.9	-2.1	-1.8	-2.1	-2.3	2.2	2.1	2.2
Area under the delay curve	0.3	0.3	1.0	0.6	-0.4	-1.0	-0.4	-0.4	-0.7	-0.6	-0.6	0.3	0.3	0.4
BMI with tail	1.6	5.2	9.1	-3.0	2.6	2.2	2.3	2.7	2.4	2.1	1.8	-2.2	-1.9	-1.6
BMI without tail	0.1	0.1	0.3	-0.6	0.4	0.2	0.3	0.5	0.2	0.0	-0.3	-0.5	-0.4	-0.3
Body weight	4.4	18.3	26.8	-4.9	4.8	5.2	4.6	4.6	4.4	4.2	3.5	-3.7	-3.3	-3.1
Weight adjusted by age	0.4	0.4	1.4	-0.2	0.8	0.4	0.5	0.6	1.0	1.2	0.8	0.1	0.3	0.2
Bone surface	0.1	0.3	0.9	0.1	-0.3	0.1	-0.3	-0.2	-0.1	-0.3	-0.8	0.7	0.7	1.0
Bone volume	0.4	0.7	2.1	0.4	-0.7	-0.4	-0.6	-0.7	-0.4	-0.7	-1.1	1.1	1.1	1.4
Breakpoint value in progressive ratio session	0.3	0.3	1.4	0.3	0.2	1.2	0.1	-0.4	0.1	0.8	0.5	0.4	0.5	-0.1
Number of licking bursts	0.3	0.4	0.9	0.4	-0.2	-0.8	-0.4	-0.4	-0.4	-0.3	-0.7	0.9	0.9	0.9
Context. condit. distance diff. score	2.0	2.4	4.3	-1.1	1.4	0.8	1.4	1.4	1.5	1.3	1.7	-1.9	-2.1	-1.9
Locomotion velocity, session 1	0.3	0.3	0.7	-0.7	0.6	0.8	0.5	0.6	0.4	0.8	0.1	-0.3	-0.2	-0.1
Locomotion distance, session 1	1.7	2.1	5.3	-1.8	1.6	2.3	1.4	1.7	1.3	1.8	0.6	-1.0	-0.9	-0.7
Locomotion velocity, session 2	0.1	0.2	0.7	-0.3	0.4	0.8	0.3	0.4	0.3	0.5	-0.0	-0.3	-0.3	-0.3
Locomotion distance, session 2	0.2	0.3	1.3	-0.4	0.3	1.2	0.1	0.3	-0.1	0.5	-0.6	0.4	0.5	0.4
Locomotion velocity, session 3	0.1	0.1	0.2	0.3	-0.2	0.5	-0.2	-0.2	0.1	-0.1	-0.4	0.1	-0.0	-0.2
Locomotion distance, session 3	0.2	0.2	0.7	-0.4	0.4	0.9	0.3	0.6	0.5	0.6	0.0	-0.3	-0.3	-0.4
Stereotopy head waving bouts, day 3	2.4	2.8	3.9	1.9	-1.8	-2.0	-1.7	-1.8	-1.7	-1.9	-1.6	1.3	1.2	1.3
Stereotopy head waving duration, day 3	0.1	0.2	0.5	0.4	-0.4	-0.7	-0.2	-0.4	-0.4	-0.6	-0.3	0.2	0.1	0.4
Locomotion velocity, session 7	0.9	1.0	2.1	-1.1	1.1	1.0	1.0	1.2	1.0	1.4	0.8	-0.6	-0.5	-0.5
Locomotion distance, session 7	0.4	0.5	1.1	-0.8	0.7	0.4	0.6	0.9	0.3	1.1	0.7	-0.6	-0.5	-0.5
Stereotopy head waving bouts, day 7	0.6	0.7	1.3	0.8	-0.7	-1.2	-0.5	-0.6	-0.7	-0.8	-1.0	0.8	0.8	1.0
Stereotopy head waving duration, day 7	0.3	0.4	0.7	0.7	-0.5	-0.6	-0.4	-0.5	-0.4	-0.6	-0.8	0.7	0.6	0.7
Locomotion velocity, session 8	7.9	9.4	10.0	-3.1	3.2	2.9	3.1	3.2	3.0	3.1	3.0	-3.2	-3.0	-2.9
Locomotion distance, session 8	1.2	1.7	2.4	-1.4	1.5	1.5	1.4	1.5	1.3	1.5	1.1	-1.2	-1.1	-1.0
Degree of sensitization distance	1.3	1.3	2.2	-1.2	1.2	0.5	1.2	1.1	0.8	1.2	1.5	-1.2	-1.2	-1.0
Degree of sensitization stereotypy	0.9	1.0	2.2	1.0	-0.9	-1.5	-0.8	-0.8	-0.9	-0.9	-1.0	1.0	1.1	1.2
Conditioned locomotion	0.1	0.1	0.4	0.6	-0.3	-0.3	-0.3	-0.3	-0.5	-0.2	-0.3	0.3	0.2	0.2
Cocaine response after cond. corrected	1.3	1.5	3.2	0.9	-0.9	-1.8	-1.0	-0.9	-1.4	-0.8	-1.0	1.2	1.3	1.7
Cocaine response after cond. not corrected	1.7	1.9	4.5	1.0	-1.0	-2.1	-1.1	-1.1	-1.5	-0.7	-1.0	1.4	1.5	1.9
Cocaine response before conditioning	0.1	0.1	0.7	0.4	-0.4	-0.8	-0.3	-0.4	-0.1	-0.1	0.0	0.2	0.1	0.2
Saline control response	0.1	0.2	0.4	-0.4	0.4	-0.6	0.4	0.5	0.1	0.6	0.5	-0.1	-0.1	0.2
Bone: connectivity density	3.4	5.4	6.8	2.5	-2.3	-2.3	-2.2	-2.3	-2.0	-2.2	-2.6	2.4	2.3	2.4
Bone: cortical apparent density	5.2	6.8	9.8	2.9	-3.1	-2.8	-3.0	-3.0	-2.8	-2.7	-2.4	2.0	1.9	1.7
Bone: cortical area	0.1	0.1	0.4	0.3	-0.2	-0.6	-0.3	-0.3	-0.3	-0.2	-0.2	0.4	0.3	0.3
Bone: cortical porosity	0.3	0.3	0.9	0.4	-0.2	-0.8	-0.4	-0.3	-0.3	-0.4	-0.4	0.7	0.7	0.9
Bone: cortical porosity	0.2	0.3	0.9	0.2	-0.1	-0.9	-0.3	-0.1	-0.2	-0.1	-0.2	0.6	0.7	1.0
Bone: cortical thickness	0.8	1.4	3.5	1.5	-1.1	-1.9	-1.2	-1.3	-1.1	-0.9	-1.0	1.0	0.8	0.8
Bone: cortical thickness	4.5	5.3	8.3	2.9	-2.5	-2.4	-2.3	-2.6	-1.9	-2.2	-2.1	2.2	2.0	2.0
Bone: cortical tissue density	5.2	6.9	9.9	2.9	-3.1	-2.8	-3.1	-3.0	-2.8	-2.7	-2.4	2.1	1.9	1.7
Condit. Reinf. active minus inactive responses	0.7	0.7	1.4	1.2	-0.8	-0.7	-1.0	-1.1	-1.0	-0.7	-1.0	0.7	0.6	0.3
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.8	1.3	-0.9	-0.9	-0.9	-1.1	-0.9	-0.8	-0.8	0.6	0.4	0.2
Condit. Reinf. active responses	0.7	0.8	1.4	1.2	-0.9	-1.0	-1.0	-1.1	-0.9	-0.7	-1.0	0.7	0.7	0.4
Condit. Reinf. inactive responses	0.2	0.2	0.8	0.3	-0.3	-0.9	-0.4	-0.4	-0.1	-0.1	-0.3	0.4	0.6	0.5
Incentive salience index mean	1.8	2.2	2.9	1.6	-1.4	-1.4	-1.7	-1.6	-1.6	-1.4	-1.7	1.4	1.3	1.1
Condit. Reinf. lever presses	1.2	1.6	2.4	1.1	-1.1	-1.3	-1.5	-1.1	-1.4	-1.0	-1.5	1.2	1.2	1.1
Condit. Reinf. active minus inactive responses	1.1	1.4	2.0	1.2	-1.3	-0.7	-1.0	-1.2	-0.9	-1.1	-1.1	1.4	1.4	1.2
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.8	0.9	-1.1	-0.6	-1.0	-1.1	-0.8	-1.1	-1.2	1.3	1.4	1.2
Condit. Reinf. active responses	1.9	2.7	4.0	1.6	-1.8	-1.0	-1.5	-1.6	-1.3	-1.7	-1.6	2.0	2.0	1.8
Condit. Reinf. inactive responses	2.2	2.7	3.3	1.6	-1.8	-1.4	-1.6	-1.5	-1.7	-1.6	-1.4	1.8	1.8	1.8
Condit. Reinf. lever presses	0.1	0.1	0.3	0.5	-0.5	-0.2	-0.2	-0.3	-0.1	-0.4	-0.1	0.5	0.4	0.2
Condit. Reinf. lever reinforcers received	1.9	2.7	3.7	1.7	-1.9	-1.0	-1.6	-1.6	-1.4	-1.6	-1.6	1.9	1.9	1.7
Conditioned reinforcement - actives	0.5	0.5	1.2	0.9	-0.6	-1.1	-0.6	-0.9	-0.6	-0.2	0.0	0.8	0.7	0.5
Conditioned reinforcement - inactives	1.6	1.8	3.0	1.3	-1.7	-1.1	-1.6	-1.7	-1.5	-1.7	-0.9	1.1	1.0	0.8
Conditioned locomotion	0.5	0.6	1.6	0.8	-0.5	-1.3	-0.9	-0.7	-0.9	0.1	-0.5	0.9	0.9	0.7
Patch foraging indifference point 0 sec	1.6	2.7	5.0	1.8	-1.7	-1.5	-1.7	-1.7	-2.2	-1.8	-1.6	1.4	1.1	1.0
Patch foraging indifference point AUC	0.0	0.1	0.4	-0.1	0.2	0.1	0.2	0.3	-0.1	0.6	0.0	0.0	0.0	0.1
Delay disc. indifference point, 0s delay	1.1	1.2	1.6	1.2	-1.1	-1.1	-0.9	-1.1	-1.3	-1.0	-1.0	1.1	1.0	1.0
Delay disc. indifference point, 16s delay	0.3	0.3	0.8	0.7	-0.5	-0.9	-0.7	-0.4	-0.7	-0.7	-0.2	-0.1	-0.3	0.1
Delay disc. indifference point, 2s delay	1.4	1.5	2.8	1.0	-1.1	-1.7	-1.1	-0.9	-1.4	-0.7	-1.3	1.3	1.3	1.4
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.2	0.4	-0.4	0.2	0.3	-0.1	-0.1	0.2	-0.4	-0.5	-0.4
Delay disc. indifference point, 4s delay	0.7	0.8	1.3	1.2	-0.9	-1.1	-0.8	-0.8	-0.8	-0.6	-0.6	0.9	0.9	0.9
Delay disc. indifference point, 8s delay	0.2	0.2	0.8	0.3	-0.1	-0.9	-0.1	-0.1	-0.5	-0.6	-0.7	0.3	0.2	0.3
Indifference point function ln k	0.1	0.1	0.3	0.1	0.1	-0.2	0.2	0.2	-0.1	-0.2	0.1	-0.4	-0.6	-0.6
Indifference point function log k	0.1	0.1	0.3	0.1	0.1	-0.2	0.2	0.2	-0.1	-0.2	0.1	-0.4	-0.6	-0.6
Patch foraging total patch changes 0 sec	1.2	1.9	3.9	1.5	-1.4	-1.2	-1.5	-1.4	-2.0	-1.5	-1.4	1.2	0.9	0.8
Patch foraging total patch changes 12 sec	6.0	7.7	9.3	2.8	-2.6	-2.5	-2.8	-2.8	-2.9	-2.4	-2.9	3.0	2.9	2.8
Patch foraging total patch changes 18 sec	0.5	0.7	1.2	0.9	-0.9	-0.7	-0.8	-0.7	-1.1	-0.6	-0.8	0.9	0.8	0.7
Patch foraging total patch changes 24 sec	1.6	1.9	3.0	1.6	-1.2	-1.7	-1.3	-1.3	-1.6	-0.7	-1.4	1.5	1.3	1.4
Patch foraging total patch changes 6 sec	2.4	3.5	5.3	1.8	-2.0	-1.5	-2.0	-1.9	-2.3	-2.0	-2.1	1.7	1.5	1.6
Patch foraging time to switch 0 sec	0.1	0.2	0.3	0.4	-0.3	-0.1	-0.5	-0.3	-0.2	-0.5	-0.4	0.5	0.5	0.5
Patch foraging water rate 0 sec	0.1	0.1	0.2	0.2	-0.4	0.0	-0.4	-0.3	-0.3	-0.4	-0.4	0.1	0.1	-0.0
Patch foraging water rate 12 sec	0.2	0.3	0.8	0.0	0.7	0.6	0.6	0.1	0.6	0.8	0.9	-0.1	-0.2	-0.5
Patch foraging water rate 18 sec	0.7	0.9	1.5	1.0	-0.5	-0.8	-0.7	-1.0	-0.6	-0.7	-1.1	1.2	1.1	1.2
Patch foraging water rate 24 sec	0.7	1.0	1.6	0.9	-1.2	-0.6	-1.1	-1.1	-0.6	-1.3	-1.3	1.0	0.9	0.8
Patch foraging water rate 6 sec	1.6	2.4	3.0	1.7	-1.5	-0.9	-1.5	-1.7	-1.6	-1.6	-1.6	1.7	1.6	1.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	0.6	-0.5	0.1	-0.7	-0.5	-0.1	0.1	0.7	-0.3	-0.4	-0.6
Distance traveled before self-admin	0.2	0.2	1.1	-0.1	-0.3	0.7	-0.0	-0.0	0.2	-0.1	1.0	0.1	0.3	0.2
Distance traveled after self-admin	1.2	1.3	2.2	-1.3	1.1	1.5	1.4	1.1	1.3	0.5	1.1	-1.1	-0.9	-0.9
Extensor digitorum longus weight	9.4	37.1	40.4	-6.3	6.3	5.7	6.2	6.2	6.4	6.3	6.0	-6.0	-5.8	-5.7
Bone: elastic displacement	0.0	0.0	0.1	-0.2	0.0	-0.2	0.0	-0.1	0.1	0.2	0.0	-0.1	-0.1	-0.3
Bone: elastic work	0.1	0.1	0.3	0.3	-0.3	-0.1	-0.3	-0.4	0.1	-0.1	-0.4	0.5	0.5	0.5
Bone: endosteal estimation	1.5	3.2	5.8	-2.3	1.9	2.4	2.0	2.1	1.7	1.6	1.7	-1.3	-1.1	-0.8
Bone: endosteal perimeter	1.1	2.2	4.6	-1.8	1.5	2.1	1.5	1.6	1.6	1.1	1.5	-1.2	-1.0	-1.0
Epididymis fat weight	0.1	0.2	1.3	-0.3	0.3	1.1	0.3	0.1	0.7	0.7	0.2	0.2	0.2	-0.1
Delta time in closed arm before/after self-admin	3.4	3.3	5.1	-2.1	1.7	1.8	1.9	1.8	2.1	2.3	1.0	-1.9	-1.7	-1.6
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.0	0.2	-0.1	-0.0	-0.1	-0.0	-0.3	0.6	-0.3	-0.2	-0.1
Diff in mean of infusions in LGA sessions	0.3	0.3	1.0	0.2	0.4	0.9	0.6	-0.2	0.7	1.0	0.5	0.3	0.3	-0.2
Delay discount exponential model param	0.1	0.1	0.6	-0.4	0.3	0.8	0.3	0.2	0.4	0.4	0.5	-0.1	-0.1	-0.2
Extinction: sum of active levers before priming	1.4	1.4	3.0	-1.4	1.7	0.9	1.4	1.4	1.0	1.3	0.8	-1.0	-0.9	-0.7
Active lever presses in extinction session 6	2.5	2.4	5.2	1.4	-1.2	-0.5	-1.4	-1.1	-1.7	-1.0	-1.2	2.2	2.3	2.2
Bone: final force	0.9	1.5	3.4	0.9	-0.9	-1.3	-0.9	-0.9	-1.1	-0.9	-1.1	1.5	1.5	1.8
Bone: final moment	0.7	1.1	2.8	0.7	-0.7	-1.2	-0.7	-0.7	-0.9	-0.8	-0.9	1.3	1.3	1.7
Food consumed during 24 hour testing period	0.7	0.8	1.2	-1.1	1.0	1.0	1.1	0.6	0.9	0.7	1.0	-0.8	-0.8	-0.7
Glucose	0.2	0.3	1.2	0.3	-0.3	-1.1	-0.5	-0.2	-0.9	-0.1	-0.2	0.4	0.3	0.7
Heart weight	3.2	4.5	6.4	-2.5	2.1	2.3	1.7	2.1	1.9	2.3	1.7	-2.3	-2.2	-2.0
Delay discount hyperbolic model param	0.3	0.3	0.9	-0.5	0.4	1.0	0.4	0.3	0.6	0.5	0.7	-0.3	-0.2	-0.4
Intermittent access intake day 1-15 change	0.4	0.4	1.0	0.9	-0.5	-0.3	-0.5	-1.0	-0.0	-0.7	-0.8	0.6	0.6	0.4
Intermittent access intake escalation	0.4	0.4	1.1	0.9	-0.4	-0.2	-0.6	-1.0	-0.1	-0.7	-0.8	0.7	0.7	0.5
Intermittent access intake escalation 2	0.1	0.1	0.2	0.1	0.2	0.3	0.0	-0.4	0.4	-0.3	-0.4	0.2	0.3	0.1
Intermitt. access day 1 inactive lever presses	2.7	2.9	6.0	1.7	-1.8	-0.6	-1.8	-1.6	-1.2	-2.3	-2.5	1.6	1.6	1.5
Intermitt. access day 15 inactive lever presses	4.5	4.9	7.5	2.4	-2.3	-1.8	-2.4	-2.3	-2.2	-2.5	-2.7	2.0	1.9	1.6
Intermitt. access escalation Index	2.1	1.8	3.6	-1.2	1.7	0.7	1.9	1.5	1.9	1.1	1.2	-1.1	-1.1	-0.7
Intermittent access day 1 total infusions	0.2	0.2	0.4	0.5	-0.6	-0.3	-0.4	-0.6	-0.6	-0.1	0.2	0.5	0.5	0.5
Intermittent access day 15 total infusions	0.5	0.5	1.3	1.0	-0.8	-0.5	-0.7	-1.1	-0.6	-0.7	-0.5	0.7	0.6	0.6
Intermittent access terminal intake (last 3 days)	0.6	0.7	1.5	1.0	-0.9	-0.5	-0.7	-1.2	-0.7	-0.9	-0.6	0.8	0.8	0.8
Intermittent access total infusions	0.2	0.2	0.5	0.6	-0.6	-0.0	-0.3	-0.7	-0.4	-0.3	0.2	0.4	0.4	0.4
Intermittent access day 1 locomotion	0.3	0.3	1.0	0.4	-0.8	-0.6	-0.6	-0.4	-1.0	-0.1	-0.1	0.3	0.3	0.3
Intermittent access day 15 total locomotion	0.3	0.3	0.7	0.4	-0.7	-0.8	-0.6	-0.7	-0.7	-0.2	-0.5	0.5	0.5	0.4
Intermittent access total locomotion	0.6	0.7	1.6	0.9	-1.1	-0.9	-0.8	-1.0	-1.3	-0.5	-0.5	0.7	0.7	0.4
Intermittent access standard deviation	1.6	1.7	3.4	1.7	-1.5	-0.3	-1.2	-1.8	-1.1	-1.5	-1.3	1.2	1.2	0.7
Left kidney weight	1.0	2.9	6.3	-1.5	1.5	2.5	1.5	1.8	2.1	1.2	1.3	-1.6	-1.7	-1.6
Right kidney weight	0.1	0.3	1.2	-0.4	0.5	1.1	0.6	0.6	1.0	0.5	0.2	-0.1	-0.1	0.1
Cocaine induced anxiety	1.3	1.5	2.5	-1.5	1.3	1.6	1.6	1.5	1.4	0.9	0.8	-0.9	-0.6	-0.5
Post-drug Anxiety	0.1	0.1	0.2	-0.4	0.3	0.2	0.5	0.5	0.2	0.3	0.5	-0.3	-0.2	0.0
Baseline Anxiety	1.1	1.1	3.6	1.2	-1.2	-1.9	-1.3	-1.1	-1.3	-0.7	-0.5	0.5	0.4	0.4
Tail length	0.3	0.9	2.7	-0.6	1.0	1.6	0.9	0.7	0.8	1.0	0.7	-0.7	-0.7	-1.0
Length with tail	2.7	9.7	18.4	-2.9	3.4	4.3	3.2	3.1	3.1	3.2	2.8	-2.6	-2.5	-2.7
Length without tail	3.2	7.0	12.5	-2.7	2.9	3.5	2.8	2.8	2.9	2.8	2.7	-1.9	-1.8	-1.8
Times rat made contact with spout	1.1	1.3	2.1	0.7	-1.1	-1.3	-1.2	-1.3	-0.9	-1.3	-1.4	1.0	1.1	1.0
Lifetime Intake	0.2	0.3	0.7	0.7	-0.7	0.1	-0.4	-0.8	-0.4	-0.4	-0.0	0.5	0.5	0.4
Liver weight, left	0.0	0.1	0.1	0.3	-0.2	0.2	-0.1	-0.2	0.3	0.1	0.0	0.3	0.3	0.1
Liver weight, right	0.6	0.9	1.6	1.3	-1.0	-0.2	-0.9	-0.9	-0.7	-0.9	-0.8	1.2	1.0	1.2
Locomotor activity	0.8	1.2	2.3	1.0	-0.6	-1.1	-0.7	-1.1	-0.8	-0.8	-1.1	1.5	1.5	1.5
Locomotor testing distance	2.2	3.7	5.1	2.0	-1.8	-2.3	-1.7	-1.9	-1.7	-2.0	-1.8	2.1	2.0	1.8
Locomotor testing rearing	6.0	9.3	11.6	3.4	-3.3	-2.9	-3.2	-3.0	-3.4	-3.3	-3.0	2.8	2.5	2.4
Locomotion in novel chamber	5.3	6.6	9.1	2.8	-2.9	-2.9	-2.7	-2.6	-3.0	-1.8	-1.7	2.5	2.4	2.5
Locomotion in novel chamber post-restriction	1.2	1.4	2.7	0.9	-1.0	-1.0	-1.1	-1.2	-1.1	-1.2	-0.9	1.5	1.6	1.4
Fecal boli incidents, locomotor time 1	0.2	0.3	0.7	-0.8	0.2	0.3	0.3	0.6	0.1	0.6	0.5	-0.6	-0.5	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	0.0	0.6	-0.3	0.4	-0.1	0.0	0.4	0.3	-0.0	-0.1	0.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.9	0.5	-0.4	-1.0	-0.5	-0.3	-0.8	0.3	-0.0	0.0	-0.1	-0.0
Bouts of movement, locomotor time 1	0.5	0.5	1.1	-0.6	0.8	0.9	1.1	0.9	1.0	0.2	0.3	-0.4	-0.3	-0.5
Total resting periods, locomotor time 1	0.9	1.0	2.2	-1.1	1.2	1.1	1.5	1.2	1.3	0.7	0.5	-0.7	-0.5	-0.7
Rest time, locomotor task time 1	0.2	0.2	1.0	-0.1	-0.0	-0.0	0.2	0.0	-0.0	-0.6	-1.0	0.4	0.4	0.4
Distance moved, locomotor task time 1	0.2	0.2	0.5	0.3	-0.7	-0.5	-0.7	-0.4	-0.5	0.4	0.5	-0.0	-0.0	0.2
Vertical activity count, locomotor time 1	0.3	0.3	2.1	-0.2	0.3	0.1	-0.0	0.1	0.0	1.5	1.0	-0.4	-0.4	-0.3
Time >=10cm from walls, locomotor time 2	1.2	1.3	2.8	1.3	-1.0	-1.7	-1.0	-0.9	-1.4	0.0	0.3	1.3	1.2	1.2
Bouts of movement, locomotor time 2	0.2	0.2	0.6	0.8	-0.4	-0.1	-0.5	-0.0	-0.1	-0.7	-0.6	0.5	0.3	0.2
Total resting periods, locomotor time 2	0.1	0.1	0.4	0.6	-0.2	0.2	-0.3	0.1	0.1	-0.5	-0.4	0.3	0.1	-0.0
Rest time, locomotor task time 2	0.8	0.9	1.7	-1.0	1.2	1.3	1.2	1.0	0.9	1.1	0.5	-0.8	-0.7	-0.8
Distance moved, locomotor task time 2	0.1	0.1	0.5	-0.2	-0.3	-0.3	-0.5	0.4	-0.4	0.7	0.1	-0.2	-0.2	0.3
Vertical activity count, locomotor time 2	0.3	0.3	1.6	-0.5	0.4	0.0	0.1	0.5	0.1	1.3	0.6	-0.7	-0.6	-0.4
Light reinforcement 1	3.1	5.7	8.8	2.5	-2.4	-1.8	-2.5	-2.4	-2.1	-2.5	-3.0	2.5	2.3	2.1
Light reinforcement 2	1.0	1.4	3.5	0.7	-1.0	-0.8	-1.2	-1.0	-1.0	-0.9	-1.9	1.2	1.2	1.5
Bone: marrow area	1.4	3.0	5.5	-2.3	1.8	2.3	1.9	2.0	1.6	1.5	1.7	-1.2	-1.0	-0.7
Bone: maximum diameter	0.1	0.1	0.3	0.2	-0.2	0.0	-0.2	-0.2	-0.2	-0.5	-0.2	0.5	0.5	0.5
Bone: maximum force	0.1	0.1	0.5	-0.1	0.2	-0.2	0.1	0.1	-0.1	-0.0	-0.1	0.4	0.4	0.7
Bone: maximum moment	0.0	0.1	0.3	-0.3	0.3	-0.1	0.3	0.3	0.1	0.1	-0.0	0.2	0.2	0.5
Mean time between licks in bursts	1.0	1.4	2.3	-1.5	1.1	1.3	1.2	1.4	1.1	0.9	1.2	-1.0	-0.9	-1.0
Mean num. licks in bursts	0.1	0.1	0.4	0.2	-0.6	-0.2	-0.5	-0.5	-0.2	-0.7	-0.4	-0.2	-0.1	-0.2
Cd content in liver	0.2	0.2	0.4	0.3	-0.4	-0.4	-0.5	-0.3	-0.5	-0.6	-0.5	0.2	0.2	0.2
Co content in liver	0.9	1.0	2.0	-1.0	0.7	1.4	0.7	0.7	1.1	0.8	0.8	-1.2	-1.1	-1.2
Cu content in liver	0.1	0.2	1.0	0.1	-0.1	1.0	-0.1	-0.1	0.0	0.0	0.1	-0.4	-0.4	-0.6
Fe content in liver	0.8	0.9	1.4	-1.0	1.1	1.2	1.0	1.0	1.1	1.1	0.8	-0.7	-0.6	-0.5
K content in liver	1.5	1.5	2.5	1.6	-1.1	-0.7	-1.1	-1.2	-1.3	-1.1	-1.0	1.4	1.3	1.3
Mg content in liver	0.7	0.7	2.3	1.5	-0.8	-0.6	-0.8	-1.0	-1.0	-1.0	-0.5	0.7	0.4	0.3
Mn content in liver	2.1	2.4	4.1	2.0	-1.5	-0.9	-1.5	-1.7	-1.6	-1.7	-1.6	1.6	1.3	1.2
Na content in liver	0.6	0.6	1.9	0.7	-0.4	-0.5	-0.4	-0.5	-0.5	-0.5	-0.5	1.1	1.2	1.4
Rb content in liver	1.5	1.8	3.4	1.4	-1.5	-1.3	-1.5	-1.4	-1.8	-1.5	-1.2	1.1	1.0	1.0
Se content in liver	5.0	6.1	8.6	2.9	-2.7	-1.6	-2.6	-2.8	-2.4	-2.8	-2.3	2.4	2.3	2.1
Sr content in liver	0.1	0.0	0.1	0.4	-0.1	0.3	-0.2	-0.3	-0.2	-0.2	-0.0	0.1	-0.1	-0.3
Zn content in liver	3.1	3.4	4.9	1.9	-2.1	-1.2	-2.0	-2.2	-1.6	-2.2	-1.9	1.7	1.7	1.5
Bone: minimum diameter	0.3	0.6	1.0	-0.9	0.9	1.0	0.8	1.0	0.6	0.7	0.7	-0.6	-0.5	-0.3
Time in familiar zone, hab. session 1	0.9	0.8	2.3	0.3	-0.7	-0.8	-0.8	-0.6	-0.6	-0.8	-1.0	1.0	1.1	1.5
Time in novel zone, hab. session 1	0.3	0.3	0.6	0.7	-0.7	-0.7	-0.7	-0.5	-0.8	-0.5	-0.6	-0.1	-0.2	-0.5
Total zone transitions, hab. session 1	1.8	2.5	3.2	-1.7	1.5	1.8	1.6	1.5	1.6	1.5	1.3	-1.7	-1.6	-1.5
Total locomotion distance, hab. session 1	0.0	0.1	0.1	-0.0	-0.1	0.2	-0.0	-0.2	0.4	0.1	-0.1	-0.3	-0.4	-0.3
Locomotion velocity, hab. session 1	0.4	0.5	1.2	-0.5	0.6	0.9	0.7	0.4	1.1	0.6	0.7	-0.6	-0.7	-0.7
Time in familiar zone, hab. session 2	0.7	0.7	1.3	0.7	-0.8	-0.6	-0.9	-0.8	-0.8	-0.9	-0.9	0.8	0.9	1.1
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	-0.4	-0.3	-0.3	-0.3	-0.3	-0.3	-0.4	0.3	0.1	-0.1
Total zone transitions, hab. session 2	0.8	1.1	1.7	-1.3	1.1	1.0	1.0	1.2	0.6	1.3	0.7	-1.1	-1.0	-0.8
Total locomotion distance, hab. session 2	0.1	0.2	0.6	-0.7	0.4	0.4	0.3	0.4	0.5	0.6	0.1	-0.4	-0.3	-0.2
Locomotion velocity, hab. session 2	0.3	0.4	0.9	-0.9	0.7	0.7	0.6	0.6	0.8	0.9	0.4	-0.6	-0.5	-0.4
Novel to familiar place preference ratio	1.4	1.4	2.0	-0.7	1.1	1.2	1.2	1.2	1.3	1.1	1.4	-1.1	-1.2	-1.3
Novelty place preference	1.3	1.3	2.0	-0.6	1.1	1.0	1.1	1.1	1.3	1.0	1.4	-1.1	-1.2	-1.3
Time in novel zone, NPP test	0.5	0.5	1.0	-0.2	0.6	0.4	0.7	0.7	0.9	0.6	1.0	-0.7	-0.8	-0.9
Total zone transitions, NPP test	0.3	0.4	1.3	-1.2	0.8	0.7	0.7	0.9	0.4	0.8	0.3	-0.4	-0.3	-0.0
Total locomotion distance, NPP test	0.1	0.1	0.3	-0.4	-0.1	-0.0	-0.1	-0.1	-0.2	0.0	-0.5	0.2	0.3	0.5
Locomotion velocity, NPP test	0.2	0.3	0.9	-1.0	0.5	0.6	0.5	0.5	0.5	0.6	0.1	-0.5	-0.4	-0.1
Intraocular pressure	2.8	4.0	5.4	-2.3	1.6	1.4	2.0	2.1	1.9	1.8	2.1	-2.3	-2.0	-2.0
Delta distance traveled before/after self-admin	1.6	1.7	2.6	-1.3	1.6	1.0	1.6	1.3	1.4	1.2	0.6	-1.4	-1.4	-1.2
Delta ambulatory time before/after self-admin	1.0	1.1	2.2	-1.2	1.5	0.5	1.4	1.3	1.1	0.7	-0.2	-1.0	-1.0	-0.7
Parametrial fat weight	1.8	3.6	5.5	1.9	-1.9	-0.8	-1.7	-2.0	-1.2	-2.2	-1.9	2.3	2.3	2.0
Pavlov. Cond. lever latency	3.5	4.4	5.6	-1.7	2.0	2.1	2.2	1.9	2.0	2.0	2.3	-2.3	-2.4	-2.4
Pavlov. Cond. magazine entry latency	10.6	13.7	15.0	3.6	-3.7	-3.9	-3.8	-3.7	-3.5	-3.7	-3.7	3.7	3.7	3.6
Pavlov. Cond. change in total contacts	8.6	9.2	11.4	3.2	-3.3	-3.2	-3.3	-3.1	-3.0	-3.4	-3.1	2.7	2.5	2.4
Pavlov. Cond. index score	9.0	11.4	12.7	3.1	-3.3	-3.6	-3.5	-3.3	-3.3	-3.3	-3.5	3.4	3.4	3.4
Pavlov. Cond. latency score	7.0	8.9	10.2	2.6	-2.9	-3.2	-3.1	-2.8	-2.9	-2.9	-3.1	3.1	3.1	3.1
Pavlov. Cond. lever contacts	2.9	3.5	4.5	1.4	-1.7	-2.0	-2.0	-1.6	-1.7	-1.8	-2.0	2.0	2.1	2.1
Pavlov. Cond. magazine entry number	12.8	16.0	18.5	-3.9	4.1	4.3	4.2	4.0	3.9	4.2	4.0	-3.8	-3.7	-3.7
Pavlov. Cond. intertrial magazine entries	1.8	2.1	2.7	-1.3	1.5	1.4	1.4	1.4	1.2	1.6	1.5	-1.6	-1.5	-1.6
Pavlov. Cond. lever-magazine prob. diff.	9.8	12.2	14.0	3.3	-3.5	-3.7	-3.7	-3.4	-3.4	-3.5	-3.5	3.5	3.5	3.4
Pavlov. Cond. response bias	9.7	11.8	13.5	3.4	-3.5	-3.7	-3.6	-3.4	-3.3	-3.5	-3.5	3.3	3.2	3.2
Pavlov. Cond. lever latency	0.4	0.5	0.8	-0.7	0.9	0.7	0.7	0.7	0.3	0.8	0.6	-0.8	-0.8	-0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.3	0.2	-0.0	0.2	-0.1	0.6	0.5	0.4	-0.1	-0.0	-0.1
Pavlov. Cond. change in total contacts	0.6	0.9	1.5	1.0	-1.2	-0.9	-1.1	-1.0	-0.9	-1.0	-0.8	0.8	0.7	0.6
Pavlov. Cond. index score	0.2	0.3	0.5	0.4	-0.7	-0.7	-0.6	-0.6	-0.2	-0.5	-0.5	0.6	0.6	0.5
Pavlov. Cond. latency score	0.1	0.2	0.4	0.2	-0.5	-0.6	-0.4	-0.4	-0.1	-0.3	-0.3	0.4	0.5	0.4
Pavlov. Cond. lever contacts	0.9	1.3	1.7	1.0	-1.2	-1.2	-1.1	-1.1	-0.8	-1.1	-1.0	1.3	1.3	1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.1	0.3	0.5	0.3	0.3	-0.1	-0.0	0.2	-0.2	-0.2	-0.2
Pavlov. Cond. intertrial magazine entries	2.1	2.7	3.6	-1.2	1.6	1.6	1.8	1.5	1.6	1.5	1.8	-1.6	-1.7	-1.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	0.2	-0.6	-0.5	-0.5	-0.5	-0.0	-0.3	-0.3	0.4	0.5	0.4
Pavlov. Cond. response bias	1.3	1.7	2.2	1.2	-1.5	-1.3	-1.4	-1.3	-1.0	-1.2	-1.2	1.4	1.5	1.3
Time in closed arm before self-admin	1.2	1.3	4.4	1.1	-1.3	-1.0	-1.2	-0.9	-1.1	-2.1	-1.4	0.7	0.4	0.6
Time in closed arm after self-admin	0.6	0.7	1.7	-0.6	0.3	0.7	0.7	0.8	1.0	0.2	0.4	-1.1	-1.3	-1.1
Time in open arm before self-admin	2.1	2.3	6.2	-1.2	1.6	1.6	1.8	1.1	1.3	2.5	1.8	-0.9	-0.8	-0.9
Time in open arm after self-admin	0.6	0.7	1.9	-0.7	1.1	0.9	0.7	0.4	0.5	1.0	1.4	-0.7	-0.5	-0.6
Bone: periosteal estimation	0.1	0.3	0.6	-0.8	0.6	0.7	0.6	0.7	0.4	0.3	0.5	-0.1	-0.0	0.2
Bone: periosteal perimeter	0.5	0.8	1.4	-1.2	1.0	1.2	0.9	1.0	1.1	0.6	0.8	-0.5	-0.4	-0.3
Bone: post-yield work	1.3	1.7	2.5	-1.5	1.5	1.1	1.4	1.6	1.4	1.2	1.0	-1.2	-1.3	-1.1
Progressive ratio test 1 active lever presses	0.6	0.6	1.4	0.9	-1.0	-1.2	-0.6	-0.6	-1.1	-0.7	-0.5	0.6	0.5	0.7
Progressive ratio test 1 breakpoint	0.5	0.5	1.1	0.8	-0.9	-1.1	-0.5	-0.5	-1.0	-0.7	-0.4	0.5	0.4	0.7
Progressive ratio test 1 inactive lever presses	1.7	1.8	3.2	1.5	-1.7	-0.8	-1.3	-1.4	-1.3	-1.8	-1.6	1.2	1.0	1.0
Progressive ratio test 2 active lever presses	1.1	1.1	1.9	1.3	-1.2	-1.1	-1.0	-1.4	-1.3	-1.1	-0.4	1.0	0.9	0.8
Progressive ratio test 2 breakpoint	0.7	0.8	1.3	1.1	-0.9	-1.1	-0.8	-1.2	-1.1	-0.9	-0.2	0.8	0.8	0.6
Progressive ratio test 2 inactive lever presses	0.5	0.5	1.2	0.8	-0.9	-0.4	-0.8	-1.1	-0.8	-0.7	-0.4	0.7	0.7	0.5
Incentive Sensitization - Responses	1.1	1.2	2.1	1.0	-1.1	-1.1	-1.2	-1.5	-1.2	-1.2	-0.4	1.0	1.1	0.8
Incentive Sensitization - Breakpoint	1.1	1.1	2.0	1.0	-1.0	-1.1	-1.1	-1.4	-1.2	-1.2	-0.4	1.1	1.1	0.8
Sum of active levers in priming session hrs 5-6	0.7	0.6	1.4	0.8	-0.4	-0.7	-0.8	-0.6	-1.2	-0.2	-0.9	0.9	0.8	1.1
Progressive ratio	0.2	0.3	0.6	0.5	-0.4	-0.0	-0.7	-0.2	-0.6	0.2	-0.4	0.7	0.8	0.6
Food seeking constrained by brief footshock	0.4	0.5	1.1	0.6	-0.5	-0.4	-0.1	-0.5	-0.7	-1.0	-0.9	0.9	0.9	0.9
Seeking ratio, punishment vs. effort	0.1	0.1	0.4	-0.1	0.1	-0.5	0.5	0.0	0.2	-0.6	0.2	-0.3	-0.3	-0.1
Retroperitoneal fat weight	0.0	0.1	0.4	-0.3	0.1	0.7	-0.1	0.2	0.0	-0.2	-0.3	-0.0	-0.1	0.1
Reaction time number correct	0.7	1.0	2.6	-1.0	1.1	1.0	0.8	0.7	1.1	1.3	1.6	-0.7	-0.6	-0.6
Reaction time mean minus median	0.4	0.5	0.9	-0.8	0.7	0.3	0.6	0.7	0.9	0.7	0.4	-0.7	-0.6	-0.9
Reaction time mean minus median AUC	0.1	0.1	0.3	-0.3	0.1	-0.5	-0.0	0.2	0.3	0.1	-0.0	-0.3	-0.2	-0.3
Reaction time num false alarms	0.8	1.1	1.8	0.7	-1.1	-1.0	-0.8	-0.9	-1.0	-0.8	-0.9	1.2	1.3	1.4
Reaction time num false alarms AUC	0.6	0.8	1.5	0.6	-0.9	-0.8	-0.7	-0.8	-0.7	-0.7	-0.8	1.2	1.2	1.2
Reaction time trials correct on left	0.7	1.0	2.6	-1.0	1.1	1.0	0.8	0.7	1.1	1.3	1.6	-0.7	-0.6	-0.6
Reaction time trials on left	0.7	1.0	2.5	-1.0	1.1	1.0	0.8	0.7	1.1	1.3	1.6	-0.7	-0.6	-0.6
Reaction time mean	0.1	0.1	0.4	0.6	-0.3	-0.1	-0.2	-0.5	0.3	-0.5	-0.3	0.2	0.1	-0.2
Reaction time mean AUC	0.1	0.1	0.4	0.6	-0.3	-0.0	-0.2	-0.5	0.3	-0.5	-0.4	0.1	0.1	-0.2
Median of all reaction times	0.6	0.8	1.8	1.3	-1.0	-0.7	-0.8	-1.3	-0.4	-1.3	-0.9	0.8	0.7	0.4
Reaction time omissions	1.1	1.5	2.3	1.2	-1.2	-1.1	-1.2	-1.5	-0.8	-1.4	-1.5	1.2	1.3	1.2
Reaction time false alarm rate	1.1	1.6	2.3	1.0	-1.3	-1.3	-1.0	-1.0	-1.1	-1.3	-1.5	1.4	1.4	1.4
Reaction time premature initiation rate	0.4	0.5	1.2	1.1	-0.4	-0.4	-0.2	-1.0	-0.3	-0.3	-0.5	0.9	0.9	0.8
Reaction time premature initiations	0.1	0.2	0.4	0.2	0.5	0.4	0.5	-0.3	0.5	0.6	0.5	0.2	0.3	0.2
Std. dev. reaction times	0.0	0.1	0.4	-0.1	0.1	-0.0	0.1	0.1	0.6	0.1	-0.1	-0.2	-0.1	-0.4
Reaction time trials completed	0.7	1.0	2.5	-1.0	1.1	1.0	0.8	0.7	1.1	1.3	1.6	-0.7	-0.6	-0.6
Reaction time trials AUC	0.6	0.9	2.5	-0.9	1.0	0.8	0.8	0.7	1.0	1.3	1.6	-0.7	-0.7	-0.7
Run reversals in cocaine runway, females	3.4	3.3	5.6	-1.3	1.7	1.6	1.7	1.3	1.6	1.9	2.4	-2.0	-2.2	-2.0
Run reversals in cocaine runway, males	0.5	0.5	1.1	0.6	-0.6	-1.0	-1.1	-0.8	-0.9	-0.8	0.2	0.4	0.4	0.5
Latency to leave start box in cocaine runway	1.5	1.7	2.7	-1.3	1.0	1.6	0.8	1.1	1.3	1.3	1.6	-1.3	-1.3	-1.3
Latency to leave start box in cocaine runway, F	1.6	1.8	4.1	-1.3	1.1	1.5	1.1	1.1	1.5	1.3	2.0	-1.3	-1.2	-1.1
Latency to leave start box in cocaine runway, M	0.3	0.3	0.9	0.3	-0.8	0.3	-0.9	-0.4	-0.6	-0.5	-0.9	0.1	-0.1	-0.1
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.2	0.1	0.4	0.1	0.3	0.5	0.1	-0.2	0.2	0.2	0.1
Total sessions with >9 infusions	0.8	0.9	1.7	1.0	-0.9	-0.9	-1.3	-0.9	-1.2	-1.0	-1.1	0.5	0.3	0.6
Short access day 1 total inactive lever presses	2.2	2.5	3.9	1.6	-2.0	-1.1	-1.9	-1.9	-1.4	-1.3	-1.8	1.4	1.3	1.3
Short access day 10 total inactive lever presses	0.1	0.2	0.8	-0.2	0.5	0.9	0.3	-0.1	0.6	0.0	-0.5	-0.1	-0.0	-0.1
Short access day 1 total infusions	0.8	0.9	1.7	1.1	-1.3	-0.2	-1.0	-1.1	-1.1	-1.1	-0.9	0.7	0.6	0.7
Short access day 10 total infusions	0.4	0.5	0.8	0.7	-0.9	-0.4	-0.6	-0.7	-0.6	-0.5	-0.4	0.8	0.8	0.8
Short access total infusions	0.3	0.3	0.7	0.9	-0.8	0.1	-0.5	-0.8	-0.5	-0.5	-0.3	0.5	0.4	0.4
Short access day 1 locomotion	4.4	4.7	7.1	2.1	-2.5	-1.6	-2.1	-2.2	-2.5	-2.5	-2.7	2.0	1.8	1.8
Short access day 10 total locomotion	1.5	1.7	3.4	1.1	-1.5	-1.6	-1.3	-1.1	-1.8	-1.1	-0.9	1.2	1.2	1.1
Short access total locomotion	0.5	0.5	1.3	0.7	-1.1	-0.5	-0.8	-0.7	-1.1	-0.7	-0.7	0.5	0.3	0.3
One hour access (0.3 mA shock)	0.0	0.0	0.2	0.2	-0.0	-0.0	0.1	-0.2	0.3	0.3	0.5	-0.1	-0.1	-0.2
Compulsive drug intake	0.7	0.7	1.9	-0.7	0.6	0.4	0.6	0.5	0.4	0.5	0.9	-1.3	-1.4	-1.4
One hour access (shock baseline)	0.4	0.4	0.8	0.8	-0.7	-0.3	-0.5	-0.7	-0.3	-0.4	-0.4	0.9	0.9	0.9
Social response proportion	0.3	0.3	0.6	-0.6	0.7	-0.0	0.5	0.8	0.3	0.7	0.3	-0.6	-0.7	-0.3
Social responses	0.2	0.2	0.7	0.1	-0.1	-0.2	-0.4	-0.1	-0.5	-0.4	-0.8	0.5	0.5	0.7
Social time	0.1	0.1	0.3	-0.5	0.1	0.3	0.1	0.0	0.4	0.0	0.0	0.3	0.5	0.6
Soleus weight	0.1	0.4	1.9	-0.3	0.2	-1.4	0.1	0.1	-0.4	0.1	-0.4	0.6	0.7	1.2
Bone: stiffness	0.1	0.1	0.5	0.1	0.1	-0.2	0.1	0.0	-0.2	-0.2	-0.1	0.4	0.3	0.7
Tibialis anterior weight	1.3	4.4	6.1	-2.4	2.4	1.9	2.3	2.2	2.5	2.2	2.0	-1.9	-1.7	-1.4
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.3	-0.1	-0.3	-0.4	-0.3	-0.1	-0.4	-0.4	-0.1	0.0	-0.0
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	0.1	-0.2	-0.4	-0.3	-0.0	-0.4	0.1	-0.4	0.4	0.5	0.3
Time to tail flick, test, before self-admin	1.7	1.6	3.2	-1.2	1.7	0.9	1.8	1.2	1.5	1.2	1.1	-1.1	-1.0	-1.1
Time to tail flick, test, after self-admin	0.3	0.3	1.0	-0.2	-0.6	-0.4	-1.0	-0.4	-0.8	-0.3	-0.8	0.3	0.5	0.5
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.3	0.4	-0.4	-0.6	-0.1	-0.3	-0.7	-0.3	-0.6	1.0	1.2	1.0
Delta time to tail flick, test, before/after SA	3.2	2.8	6.0	1.2	-2.2	-1.5	-2.4	-1.6	-2.2	-1.3	-1.6	1.3	1.3	1.4
Tibia length	1.2	3.3	5.5	-2.3	2.1	1.3	2.0	2.1	1.9	2.1	1.8	-1.6	-1.3	-0.9
Ambulatory time before self-admin	0.2	0.2	1.2	-0.2	-0.1	0.9	0.2	0.0	0.3	-0.0	1.1	-0.2	-0.1	-0.3
Ambulatory time after self-admin	1.9	2.0	3.9	-1.7	1.4	2.0	1.8	1.5	1.7	0.5	0.8	-1.3	-1.1	-1.0
Bone: tissue strength	1.0	1.0	1.3	-1.1	1.1	0.4	1.0	1.1	1.0	1.0	0.8	-1.0	-1.0	-1.0
Total heroin consumption	2.3	2.7	5.4	1.6	-1.4	-0.7	-1.3	-1.9	-1.4	-0.9	-1.4	2.3	2.3	2.1
Bone: trabecular number	5.8	9.1	10.8	3.0	-3.0	-3.0	-2.8	-3.0	-2.7	-2.9	-3.1	3.2	3.1	3.3
Bone: trabecular spacing	1.2	1.6	2.9	-1.7	1.4	1.1	1.3	1.4	1.1	1.4	1.4	-1.2	-0.9	-0.7
Bone: trabecular thickness	0.2	0.2	0.6	0.3	-0.5	-0.3	-0.4	-0.4	0.1	-0.5	-0.7	0.4	0.4	0.4
Bone: trabecular tissue density	0.2	0.2	0.9	0.1	0.1	-0.0	0.3	0.2	-0.1	0.3	0.5	-0.7	-0.9	-1.0
Water consumed over 24 hours	0.1	0.1	0.2	-0.4	0.3	0.1	0.3	-0.2	0.4	0.1	0.1	-0.2	-0.2	-0.1
Number of responses in last shaping day	0.5	0.5	1.2	0.8	-1.1	0.1	-1.1	-0.8	-0.9	-0.8	-0.7	0.3	0.2	0.1