Hub : Genes

Rapgefl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Rapgefl1 0.12 0.07 5.5e-05 0.11 0.08 0.1 0.09 2.6e-06 5.5e-05 4.5e-06 1.1e-05
2 NAcc mRNA stability Rapgefl1 0.08 0.06 5.8e-10 0.05 0.06 0.07 0.07 9.3e-08 1.2e-09 1.9e-10 1.4e-10
3 IC gene expression Rapgefl1 0.13 0.08 4.7e-06 0.06 0.1 0.06 0.07 2.0e-03 7.2e-05 2.0e-03 7.6e-04
4 IL gene expression Rapgefl1 0.24 0.14 3.0e-04 0.16 0.09 0.16 0.16 1.1e-04 3.4e-03 8.8e-05 1.4e-04
5 IC mRNA stability Rapgefl1 0.15 0.09 6.8e-06 0.07 0.06 0.08 0.07 8.6e-04 1.4e-03 3.7e-04 1.0e-03
6 IC intron excision ratio chr10_84293638_84294928 0.11 0.1 5.7e-04 0.04 0.06 0.04 0.03 7.7e-03 2.2e-03 7.4e-03 1.5e-02
7 PL mRNA stability Rapgefl1 0.31 0.14 0.0e+00 0.2 0.17 0.18 0.18 4.9e-21 1.9e-18 4.6e-19 1.4e-19
8 OFC gene expression Rapgefl1 0.18 0.12 2.9e-03 0.08 0.05 0.03 0.04 6.1e-03 2.6e-02 6.5e-02 5.1e-02
9 OFC mRNA stability Rapgefl1 0.18 0.12 1.9e-03 0.05 0.01 0.03 0.04 2.9e-02 1.7e-01 5.6e-02 3.9e-02
10 BLA mRNA stability Rapgefl1 0.35 0.18 8.7e-10 0.14 0.14 0.13 0.14 5.7e-08 7.3e-08 2.6e-07 7.6e-08
11 Brain gene expression Rapgefl1 0.16 0.07 0.0e+00 0.23 0.23 0.22 0.23 6.8e-21 4.2e-21 2.0e-20 1.7e-21
12 PL gene expression Rapgefl1 0.12 0.06 5.8e-14 0.13 0.12 0.13 0.12 5.4e-14 8.0e-13 1.1e-13 1.8e-13
13 IC isoform ratio XM_039087397.2 0.06 0.05 6.6e-03 0.07 0.04 0.04 0.03 7.6e-04 9.7e-03 1.2e-02 1.7e-02
14 Brain mRNA stability Rapgefl1 0.07 0.04 2.1e-08 0.08 0.1 0.09 0.09 5.4e-08 1.6e-09 1.5e-08 1.4e-08
15 IL mRNA stability Rapgefl1 0.63 0.34 1.5e-05 0.14 0.23 0.14 0.15 3.9e-04 2.9e-06 2.8e-04 2.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density2.44.46.0-2.22.12.0-2.1-1.91.9-1.9-2.5-2.5-2.02.0-2.01.92.22.4
Area under the delay curve0.30.51.3-0.50.90.8-1.1-0.80.7-0.9-0.4-0.4-0.50.5-0.60.50.50.7
BMI with tail2.17.510.92.9-3.1-3.32.83.0-3.32.82.12.12.9-2.82.7-3.0-2.1-1.8
BMI without tail0.63.35.61.7-2.3-2.32.21.8-2.31.70.80.81.8-1.81.9-2.4-1.3-1.0
Body weight6.126.635.15.6-5.6-5.95.85.4-5.75.24.54.55.4-5.15.0-5.1-4.0-3.8
Weight adjusted by age0.10.30.70.60.1-0.40.40.7-0.30.80.80.80.6-0.20.0-0.00.30.3
Bone surface0.10.21.2-0.50.3-0.0-0.3-0.1-0.0-0.2-0.7-0.7-0.30.2-0.2-0.20.81.1
Bone volume0.30.62.3-0.80.60.2-0.6-0.40.2-0.5-0.9-0.9-0.70.6-0.5-0.11.21.5
Breakpoint value in progressive ratio session0.20.31.70.6-0.3-0.31.30.4-0.00.60.60.60.40.1-0.10.40.1-0.5
Number of licking bursts0.10.20.8-0.30.40.2-0.6-0.30.1-0.4-0.2-0.2-0.30.5-0.6-0.20.90.8
Context. condit. distance diff. score1.41.73.71.2-0.9-1.01.01.4-0.91.31.41.41.4-1.51.6-0.0-1.9-1.6
Locomotion velocity, session 10.40.51.30.8-0.6-0.90.80.7-0.80.50.50.50.6-0.70.7-1.1-0.4-0.2
Locomotion distance, session 12.02.65.71.4-2.0-2.01.91.7-1.91.50.80.81.5-1.61.6-2.4-1.0-0.8
Locomotion velocity, session 20.10.20.50.6-0.4-0.40.70.3-0.30.40.10.10.3-0.40.4-0.3-0.3-0.4
Locomotion distance, session 20.20.31.30.2-0.8-0.60.70.3-0.60.2-0.5-0.50.2-0.10.1-1.10.40.3
Locomotion velocity, session 30.10.10.5-0.1-0.10.20.2-0.10.20.1-0.6-0.6-0.10.1-0.10.70.0-0.3
Locomotion distance, session 30.20.20.50.5-0.7-0.50.60.6-0.60.50.10.10.7-0.40.3-0.5-0.3-0.5
Stereotopy head waving bouts, day 32.73.24.2-1.82.02.0-2.0-1.91.9-1.8-1.9-1.9-1.81.6-1.51.81.31.4
Stereotopy head waving duration, day 30.20.30.6-0.50.70.5-0.8-0.50.5-0.6-0.6-0.6-0.70.3-0.20.40.30.6
Locomotion velocity, session 71.11.22.11.1-1.0-1.21.01.1-1.30.91.41.41.0-1.10.8-1.3-0.5-0.6
Locomotion distance, session 70.50.71.70.7-0.9-0.90.70.7-0.90.51.11.10.7-0.80.6-1.3-0.5-0.6
Stereotopy head waving bouts, day 70.91.12.0-0.71.31.0-1.4-1.00.9-1.2-1.2-1.2-0.80.8-0.81.11.01.2
Stereotopy head waving duration, day 70.40.51.2-0.20.90.6-0.8-0.60.7-0.6-0.8-0.8-0.40.6-0.51.10.70.8
Locomotion velocity, session 87.79.310.63.1-3.0-3.13.23.2-3.03.02.92.93.1-3.23.2-2.6-3.2-2.8
Locomotion distance, session 81.31.82.31.3-1.5-1.51.51.5-1.41.41.11.11.4-1.51.5-1.3-1.2-1.0
Degree of sensitization distance1.11.22.11.0-1.1-1.10.91.0-1.10.81.51.50.8-1.21.1-1.3-1.1-1.0
Degree of sensitization stereotypy1.01.12.3-0.71.40.9-1.5-0.90.8-1.2-1.1-1.1-0.70.9-0.81.11.01.3
Conditioned locomotion0.20.31.0-0.30.60.6-0.4-0.60.7-0.5-0.3-0.3-0.40.5-0.51.00.40.3
Cocaine response after cond. corrected0.91.43.2-1.31.40.7-1.5-1.00.6-1.6-1.4-1.4-0.70.8-0.8-0.01.21.8
Cocaine response after cond. not corrected1.11.53.6-1.31.60.8-1.7-1.00.7-1.7-1.4-1.4-0.60.8-0.9-0.11.31.9
Cocaine response before conditioning0.00.00.2-0.20.50.2-0.3-0.10.2-0.20.00.0-0.10.0-0.10.10.10.1
Saline control response0.40.50.90.5-0.2-0.90.20.8-0.90.30.90.90.8-0.90.9-0.9-0.6-0.1
Bone: connectivity density3.75.98.4-2.62.32.4-2.4-2.32.3-2.2-2.9-2.9-2.32.3-2.32.12.42.5
Bone: cortical apparent density4.47.09.4-2.82.83.1-2.7-2.73.0-2.6-2.5-2.5-2.62.6-2.43.01.81.6
Bone: cortical area0.10.20.5-0.40.70.4-0.6-0.30.4-0.5-0.1-0.1-0.40.3-0.20.70.50.5
Bone: cortical porosity0.50.61.6-0.71.10.5-1.0-0.70.5-0.9-0.2-0.2-0.60.6-0.60.30.91.3
Bone: cortical porosity0.30.31.3-0.50.90.1-0.9-0.30.1-0.80.10.1-0.30.2-0.2-0.00.61.2
Bone: cortical thickness1.11.94.4-1.31.81.5-1.6-1.21.5-1.3-1.2-1.2-1.21.2-1.12.11.01.0
Bone: cortical thickness4.85.98.7-2.52.92.7-2.4-2.42.8-2.2-2.1-2.1-2.42.4-2.32.92.12.2
Bone: cortical tissue density4.47.09.4-2.82.83.1-2.7-2.83.0-2.6-2.5-2.5-2.62.6-2.52.91.91.7
Condit. Reinf. active minus inactive responses1.11.32.0-1.21.01.3-0.8-1.21.3-1.0-1.4-1.4-1.01.1-1.21.40.70.4
Condit. Reinf. active-inactive response ratio1.41.53.2-1.21.21.5-1.0-1.31.5-1.1-1.3-1.3-0.91.2-1.21.80.70.4
Condit. Reinf. active responses1.01.21.7-1.21.11.3-0.9-1.11.3-1.0-1.2-1.2-1.11.2-1.21.20.70.5
Condit. Reinf. inactive responses0.10.10.2-0.30.50.2-0.4-0.20.2-0.3-0.1-0.1-0.40.3-0.4-0.10.40.4
Incentive salience index mean2.12.63.4-1.81.61.7-1.4-1.71.7-1.6-1.9-1.9-1.61.7-1.71.51.41.1
Condit. Reinf. lever presses1.42.12.5-1.61.51.3-1.4-1.41.3-1.5-1.6-1.6-1.51.5-1.41.01.51.3
Condit. Reinf. active minus inactive responses0.71.12.0-1.00.91.1-0.7-1.01.1-0.7-0.7-0.7-1.31.3-1.40.81.41.0
Condit. Reinf. active-inactive response ratio0.60.91.8-1.00.70.9-0.7-0.90.9-0.7-0.8-0.8-1.31.2-1.30.51.31.0
Condit. Reinf. active responses1.31.93.3-1.41.21.3-1.0-1.31.3-1.1-1.0-1.0-1.61.7-1.80.91.81.4
Condit. Reinf. inactive responses1.32.02.6-1.51.51.3-1.4-1.41.3-1.5-1.2-1.2-1.31.5-1.50.81.61.6
Condit. Reinf. lever presses0.10.10.2-0.30.30.4-0.2-0.30.4-0.2-0.3-0.3-0.20.4-0.40.40.30.0
Condit. Reinf. lever reinforcers received1.52.13.3-1.51.31.5-1.1-1.41.5-1.2-1.2-1.2-1.61.7-1.81.21.81.4
Conditioned reinforcement - actives0.00.10.50.10.50.3-0.7-0.30.2-0.30.60.60.00.3-0.3-0.10.10.0
Conditioned reinforcement - inactives0.00.10.3-0.40.10.4-0.2-0.50.4-0.4-0.3-0.3-0.50.5-0.30.10.1-0.0
Conditioned locomotion0.40.61.5-0.60.70.9-1.2-0.90.7-1.0-0.5-0.5-0.60.8-1.00.11.00.7
Patch foraging indifference point 0 sec1.02.94.0-1.81.71.9-1.8-1.91.7-2.0-1.7-1.7-1.61.6-1.61.61.41.1
Patch foraging indifference point AUC0.00.00.1-0.00.3-0.1-0.2-0.1-0.1-0.4-0.0-0.00.1-0.20.10.10.00.4
Delay disc. indifference point, 0s delay1.82.02.7-1.41.41.5-1.6-1.51.4-1.6-0.9-0.9-1.51.4-1.41.61.41.4
Delay disc. indifference point, 16s delay0.30.41.3-0.61.10.8-0.8-0.60.9-0.7-0.4-0.4-0.50.1-0.20.8-0.20.4
Delay disc. indifference point, 2s delay1.21.42.9-1.11.31.1-1.7-1.10.9-1.5-1.0-1.0-1.21.0-1.10.41.31.5
Delay disc. indifference point, 24s delay0.10.10.30.4-0.1-0.2-0.10.1-0.3-0.00.40.40.6-0.40.4-0.5-0.6-0.4
Delay disc. indifference point, 4s delay1.11.12.0-1.01.41.2-1.2-1.01.2-0.9-0.4-0.4-1.01.0-1.11.11.11.2
Delay disc. indifference point, 8s delay0.10.10.60.00.40.4-0.8-0.50.3-0.6-0.2-0.2-0.10.2-0.30.10.30.4
Indifference point function ln k0.00.10.20.1-0.00.2-0.10.00.10.2-0.2-0.20.1-0.20.20.3-0.4-0.5
Indifference point function log k0.00.10.20.1-0.00.2-0.10.00.10.2-0.2-0.20.1-0.20.20.3-0.4-0.5
Patch foraging total patch changes 0 sec0.61.93.1-1.51.41.5-1.5-1.61.3-1.8-1.4-1.4-1.31.2-1.31.21.10.8
Patch foraging total patch changes 12 sec4.56.07.9-2.42.52.5-2.6-2.52.4-2.6-2.1-2.1-2.52.5-2.61.92.82.6
Patch foraging total patch changes 18 sec0.20.40.8-0.60.80.6-0.7-0.80.5-0.9-0.4-0.4-0.60.6-0.70.60.70.4
Patch foraging total patch changes 24 sec0.41.42.3-1.11.51.2-1.5-1.11.2-1.2-1.0-1.0-0.81.0-1.21.31.21.3
Patch foraging total patch changes 6 sec1.62.73.8-1.71.71.6-1.7-1.81.5-2.0-1.8-1.8-1.71.6-1.41.41.51.4
Patch foraging time to switch 0 sec0.00.10.2-0.40.10.2-0.1-0.30.3-0.2-0.2-0.2-0.30.5-0.30.10.50.4
Patch foraging water rate 0 sec0.00.20.5-0.40.20.4-0.1-0.40.4-0.2-0.7-0.7-0.40.3-0.40.50.2-0.0
Patch foraging water rate 12 sec0.10.31.00.8-0.2-0.20.80.40.00.91.01.00.4-0.10.10.4-0.2-0.6
Patch foraging water rate 18 sec0.40.81.6-0.71.10.8-0.7-0.70.8-0.4-1.0-1.0-0.60.8-1.00.91.31.2
Patch foraging water rate 24 sec0.50.71.7-1.10.60.8-0.4-0.80.8-0.5-1.1-1.1-1.30.8-0.80.60.80.7
Patch foraging water rate 6 sec1.62.43.2-1.61.51.6-1.0-1.51.7-1.2-1.8-1.8-1.51.6-1.81.61.61.2
Seeking ratio, delayed vs. immediate footshock0.20.20.8-0.30.20.20.50.20.40.30.60.6-0.20.10.00.8-0.7-0.9
Distance traveled before self-admin0.10.10.3-0.20.50.10.5-0.10.30.00.50.5-0.50.5-0.40.10.50.4
Distance traveled after self-admin0.30.51.11.0-0.8-0.81.00.7-0.70.80.40.40.4-0.60.7-0.7-0.6-0.5
Extensor digitorum longus weight9.538.042.56.5-6.2-6.36.26.3-6.26.16.36.36.2-6.26.2-5.2-6.1-6.0
Bone: elastic displacement0.00.00.2-0.1-0.4-0.1-0.1-0.0-0.2-0.2-0.0-0.00.0-0.10.2-0.4-0.2-0.2
Bone: elastic work0.10.10.5-0.40.30.2-0.3-0.20.2-0.4-0.4-0.4-0.40.3-0.20.30.50.7
Bone: endosteal estimation1.84.47.62.2-2.2-2.52.12.0-2.51.82.22.21.9-2.02.0-2.8-1.2-0.9
Bone: endosteal perimeter1.22.93.81.7-2.0-2.01.91.7-2.01.71.91.91.4-1.61.6-1.9-1.2-1.2
Epididymis fat weight0.10.40.60.7-0.4-0.80.60.7-0.70.60.70.70.6-0.50.5-0.7-0.2-0.1
Delta time in closed arm before/after self-admin4.13.85.02.0-2.2-2.22.12.2-2.12.01.21.22.1-2.22.2-1.6-1.9-1.6
Delta time in open arm before/after self-admin0.00.00.10.10.20.00.10.10.10.10.10.10.2-0.00.20.1-0.4-0.2
Diff in mean of infusions in LGA sessions0.00.10.40.2-0.30.00.60.20.10.4-0.1-0.10.00.3-0.30.50.4-0.0
Delay discount exponential model param0.20.30.80.4-0.7-0.60.90.6-0.60.70.40.40.3-0.30.4-0.3-0.3-0.5
Extinction: sum of active levers before priming0.91.32.41.3-0.9-1.40.81.2-1.40.80.90.91.6-1.41.4-1.1-1.1-0.7
Active lever presses in extinction session 60.70.73.0-0.70.90.3-0.5-0.70.4-1.0-0.5-0.5-0.60.7-0.70.51.51.7
Bone: final force0.71.23.3-1.01.30.7-1.4-1.00.6-1.3-0.8-0.8-0.90.9-0.80.61.41.8
Bone: final moment0.50.92.8-0.81.10.5-1.2-0.80.4-1.2-0.7-0.7-0.80.7-0.60.51.21.7
Food consumed during 24 hour testing period0.61.11.81.2-1.2-1.01.01.1-1.11.21.31.30.8-0.91.1-1.1-0.8-0.8
Glucose0.10.20.9-0.30.5-0.1-0.8-0.2-0.2-1.0-0.2-0.2-0.1-0.20.2-0.50.30.9
Heart weight3.14.96.52.2-2.2-2.52.32.4-2.42.02.12.12.1-2.22.6-2.2-2.1-1.9
Delay discount hyperbolic model param0.20.20.80.4-0.7-0.60.90.5-0.50.60.30.30.3-0.30.4-0.3-0.3-0.5
Intermittent access intake day 1-15 change0.00.20.40.0-0.10.30.5-0.00.40.5-0.6-0.6-0.10.3-0.50.60.30.0
Intermittent access intake escalation0.00.20.50.1-0.10.20.50.10.40.6-0.7-0.7-0.10.3-0.40.50.20.0
Intermittent access intake escalation 20.20.31.10.6-0.8-0.51.00.6-0.51.1-0.3-0.30.5-0.40.3-0.4-0.3-0.4
Intermitt. access day 1 inactive lever presses0.22.54.5-1.81.31.5-0.7-1.41.8-1.1-2.1-2.1-1.61.5-1.51.91.41.2
Intermitt. access day 15 inactive lever presses0.42.34.2-1.51.01.7-1.1-1.61.6-1.5-2.0-2.0-1.51.6-1.61.61.00.6
Intermitt. access escalation Index0.72.23.81.8-1.1-1.41.11.8-1.42.01.81.81.7-1.51.5-0.7-1.1-0.8
Intermittent access day 1 total infusions0.00.10.50.20.30.1-0.1-0.10.2-0.10.70.7-0.30.10.1-0.0-0.10.0
Intermittent access day 15 total infusions0.00.10.20.30.10.10.40.10.30.40.10.1-0.10.1-0.00.4-0.2-0.1
Intermittent access terminal intake (last 3 days)0.10.10.3-0.10.30.40.0-0.30.6-0.1-0.4-0.4-0.50.4-0.30.50.10.2
Intermittent access total infusions0.10.10.20.30.20.10.3-0.10.30.10.50.5-0.20.10.00.2-0.3-0.2
Intermittent access day 1 locomotion0.00.10.4-0.20.30.2-0.4-0.40.1-0.60.30.3-0.40.1-0.0-0.2-0.00.1
Intermittent access day 15 total locomotion0.10.30.7-0.70.40.5-0.8-0.60.4-0.8-0.4-0.4-0.70.4-0.5-0.30.60.6
Intermittent access total locomotion0.70.81.6-0.91.11.0-1.1-1.10.9-1.3-0.5-0.5-1.10.9-1.00.50.70.7
Intermittent access standard deviation0.31.62.5-1.10.91.4-0.3-1.31.6-0.8-1.4-1.4-1.51.5-1.61.51.10.7
Left kidney weight0.21.94.71.4-1.5-1.42.21.5-1.12.11.31.31.1-1.11.4-0.1-1.1-1.2
Right kidney weight0.00.10.50.1-0.3-0.30.60.3-0.10.7-0.1-0.1-0.10.1-0.00.10.50.6
Cocaine induced anxiety1.23.24.81.8-2.2-2.02.21.9-1.91.81.31.32.0-1.91.7-1.5-1.5-1.4
Post-drug Anxiety0.70.81.30.8-0.9-0.91.11.0-0.91.10.60.61.1-0.90.8-0.5-1.0-1.0
Baseline Anxiety1.01.74.2-1.42.01.6-2.0-1.31.4-1.1-0.6-0.6-1.31.3-1.41.01.00.9
Tail length0.31.84.41.4-1.5-1.42.11.2-1.11.31.31.31.4-1.21.2-1.0-1.2-1.4
Length with tail2.310.418.93.5-3.5-3.44.33.3-3.13.53.23.23.4-2.92.8-2.5-2.5-2.7
Length without tail1.89.411.33.3-3.1-3.33.43.2-3.23.13.23.23.2-3.02.8-2.7-2.3-2.4
Times rat made contact with spout0.70.81.4-0.80.70.8-1.1-1.00.7-1.1-0.8-0.8-1.21.1-0.80.31.01.0
Lifetime Intake0.10.10.30.00.50.40.2-0.30.6-0.10.20.2-0.40.4-0.20.5-0.1-0.0
Liver weight, left0.20.41.10.5-0.4-0.80.50.7-0.80.60.40.40.7-0.70.6-1.0-0.2-0.1
Liver weight, right0.50.91.5-1.01.10.8-0.9-0.90.9-1.1-1.2-1.2-0.80.4-0.50.90.61.2
Locomotor activity0.50.92.1-0.81.10.7-1.0-0.80.7-0.8-0.7-0.7-0.70.9-1.00.31.41.4
Locomotor testing distance1.43.54.8-2.02.11.9-2.2-1.81.8-1.7-1.7-1.7-1.71.8-2.01.62.01.9
Locomotor testing rearing2.810.113.2-3.63.43.4-3.2-3.43.3-3.3-3.3-3.3-3.22.9-3.03.12.72.5
Locomotion in novel chamber4.76.39.8-2.93.12.6-2.7-2.62.6-2.9-1.6-1.6-2.82.5-2.42.02.32.4
Locomotion in novel chamber post-restriction0.20.51.1-0.90.50.5-0.6-0.70.4-0.7-0.8-0.8-0.81.0-0.80.11.00.8
Fecal boli incidents, locomotor time 10.10.41.50.5-0.7-0.70.40.4-0.70.10.40.40.4-0.60.6-1.2-0.6-0.6
Change in fecal boli incidents, locomotor task0.10.10.30.00.40.3-0.6-0.20.3-0.3-0.0-0.0-0.10.1-0.10.30.30.5
Time >=10cm from walls, locomotor time 10.20.31.0-0.50.80.6-0.9-0.50.5-0.80.10.1-0.10.3-0.31.00.00.0
Bouts of movement, locomotor time 10.30.41.10.7-0.6-0.70.80.7-0.71.00.30.30.8-0.60.4-0.5-0.4-0.6
Total resting periods, locomotor time 10.80.91.61.1-0.9-1.11.01.0-1.11.30.60.61.1-1.00.7-1.2-0.6-0.8
Rest time, locomotor task time 10.10.20.60.3-0.3-0.20.1-0.0-0.20.2-0.8-0.8-0.20.1-0.0-0.80.40.2
Distance moved, locomotor task time 10.00.10.4-0.60.70.1-0.30.00.3-0.30.50.5-0.1-0.10.10.5-0.30.2
Vertical activity count, locomotor time 10.10.41.80.3-0.1-0.50.40.6-0.40.21.41.40.7-0.60.5-0.5-0.6-0.4
Time >=10cm from walls, locomotor time 20.41.22.7-0.81.71.1-1.5-1.01.1-1.30.50.5-0.71.0-1.11.21.31.2
Bouts of movement, locomotor time 20.20.52.4-0.90.70.8-0.3-0.70.9-0.3-0.5-0.5-0.40.6-0.71.60.70.2
Total resting periods, locomotor time 20.10.32.1-0.60.50.6-0.0-0.40.7-0.0-0.4-0.4-0.20.5-0.51.50.4-0.0
Rest time, locomotor task time 20.50.91.71.3-1.0-1.01.11.0-1.00.80.70.71.0-0.80.8-1.0-0.7-0.8
Distance moved, locomotor task time 20.10.10.4-0.30.2-0.4-0.20.2-0.4-0.30.10.10.2-0.50.6-0.4-0.30.3
Vertical activity count, locomotor time 20.20.41.00.4-0.4-0.60.30.6-0.70.20.60.60.7-0.80.8-1.0-0.8-0.5
Light reinforcement 11.04.75.3-2.12.02.2-1.9-2.22.2-2.0-2.2-2.2-2.32.2-2.32.12.32.0
Light reinforcement 20.51.12.5-1.30.80.6-1.0-0.90.6-1.2-1.6-1.6-1.00.7-0.70.11.11.6
Bone: marrow area1.74.17.22.1-2.2-2.52.02.0-2.51.72.12.11.9-2.02.0-2.7-1.2-0.9
Bone: maximum diameter0.00.10.3-0.10.30.1-0.0-0.10.1-0.00.20.2-0.30.2-0.30.20.50.4
Bone: maximum force0.00.10.40.20.1-0.4-0.10.2-0.4-0.10.10.10.2-0.30.3-0.20.30.6
Bone: maximum moment0.10.10.30.4-0.0-0.50.10.4-0.50.10.20.20.3-0.40.5-0.30.10.5
Mean time between licks in bursts0.42.33.61.5-1.9-1.71.61.5-1.81.51.11.11.4-1.41.5-1.6-1.2-1.4
Mean num. licks in bursts0.00.10.3-0.30.10.4-0.3-0.40.4-0.4-0.4-0.4-0.50.2-0.10.4-0.2-0.0
Cd content in liver1.61.82.61.4-1.6-1.41.41.3-1.41.31.01.01.2-1.21.3-1.5-1.4-1.3
Co content in liver2.12.43.61.4-1.8-1.41.71.6-1.41.71.31.31.5-1.51.6-1.1-1.9-1.9
Cu content in liver0.10.21.0-0.30.10.30.4-0.20.5-0.0-0.4-0.4-0.10.2-0.21.0-0.2-0.5
Fe content in liver1.51.83.01.2-1.3-1.61.41.4-1.61.01.31.31.3-1.41.5-1.7-1.0-0.7
K content in liver1.21.23.5-0.81.51.2-0.7-1.01.4-0.8-0.5-0.5-0.81.0-1.11.91.00.9
Mg content in liver0.90.94.2-0.71.41.3-0.7-1.01.4-0.7-0.4-0.4-0.60.7-0.82.10.30.2
Mn content in liver1.21.33.3-1.01.31.5-0.8-1.31.6-1.0-0.9-0.9-1.01.1-1.21.80.80.5
Na content in liver0.40.41.9-0.40.90.3-0.5-0.50.4-0.6-0.3-0.3-0.50.6-0.70.31.11.4
Rb content in liver1.82.14.3-1.71.51.5-1.7-1.71.3-2.1-1.7-1.7-1.31.2-1.11.00.91.0
Se content in liver7.48.811.7-2.83.33.3-2.5-3.13.4-2.8-2.8-2.8-2.93.0-3.13.32.62.3
Sr content in liver0.40.41.10.7-0.5-0.00.90.40.10.70.80.80.4-0.30.20.6-0.6-1.1
Zn content in liver3.54.05.4-2.22.12.2-1.6-2.02.3-1.7-2.2-2.2-2.22.0-2.02.31.61.5
Bone: minimum diameter0.40.71.20.9-0.5-1.10.70.9-1.10.51.01.00.8-0.91.0-0.8-0.6-0.3
Time in familiar zone, hab. session 10.30.31.7-0.70.50.0-0.4-0.30.0-0.5-0.3-0.3-0.40.3-0.3-0.80.91.3
Time in novel zone, hab. session 10.50.61.7-0.50.51.0-0.7-0.80.9-0.8-1.0-1.0-0.40.6-0.61.3-0.1-0.5
Total zone transitions, hab. session 11.92.63.21.4-1.7-1.61.81.8-1.51.71.51.51.5-1.71.6-1.6-1.7-1.5
Total locomotion distance, hab. session 10.00.00.2-0.0-0.30.00.30.30.10.40.00.00.1-0.10.2-0.1-0.4-0.4
Locomotion velocity, hab. session 10.40.51.30.7-0.7-0.50.90.9-0.41.10.80.80.6-0.50.5-0.4-0.6-0.7
Time in familiar zone, hab. session 20.60.71.5-1.00.90.7-0.8-0.70.7-0.9-0.9-0.9-0.50.7-0.70.40.91.2
Time in novel zone, hab. session 20.10.10.4-0.20.10.4-0.2-0.40.4-0.2-0.4-0.4-0.40.4-0.40.60.2-0.3
Total zone transitions, hab. session 21.01.22.90.8-1.1-1.30.91.1-1.40.70.60.61.3-1.31.3-1.7-1.1-0.8
Total locomotion distance, hab. session 20.30.41.70.3-0.9-0.70.40.7-0.80.50.10.10.6-0.50.6-1.3-0.4-0.3
Locomotion velocity, hab. session 20.50.72.00.6-1.1-0.90.71.0-1.00.80.50.50.9-0.70.8-1.4-0.6-0.5
Novel to familiar place preference ratio1.11.43.01.5-0.9-0.81.31.1-0.71.51.71.71.1-1.00.9-0.0-1.1-1.3
Novelty place preference1.01.33.01.5-0.8-0.71.21.0-0.61.41.71.71.1-0.90.80.1-1.1-1.3
Time in novel zone, NPP test0.50.61.71.1-0.4-0.30.70.6-0.21.01.31.30.8-0.60.50.4-0.8-0.9
Total zone transitions, NPP test0.50.84.20.3-0.9-1.20.50.9-1.30.40.40.40.8-1.00.9-2.0-0.40.0
Total locomotion distance, NPP test0.20.21.8-0.3-0.4-0.4-0.20.3-0.5-0.1-0.5-0.50.1-0.20.3-1.30.20.5
Locomotion velocity, NPP test0.40.62.90.3-1.0-0.90.50.8-1.00.60.20.20.3-0.60.9-1.7-0.4-0.1
Intraocular pressure2.94.78.02.0-2.3-2.31.72.1-2.42.11.91.91.8-2.22.1-2.8-2.4-2.1
Delta distance traveled before/after self-admin1.21.32.21.5-1.3-1.10.81.2-1.21.10.70.71.3-1.31.3-1.0-1.4-1.1
Delta ambulatory time before/after self-admin0.91.52.91.7-1.4-1.30.61.2-1.51.00.40.41.5-1.51.4-1.4-1.2-0.8
Parametrial fat weight0.41.12.4-1.10.70.8-0.7-1.00.8-0.8-1.1-1.1-0.91.3-1.30.41.51.4
Pavlov. Cond. lever latency2.63.34.92.0-1.7-1.41.91.8-1.32.02.12.11.8-1.81.8-0.5-2.1-2.2
Pavlov. Cond. magazine entry latency10.213.115.1-3.93.83.6-3.7-3.63.5-3.5-3.5-3.5-3.83.7-3.62.83.73.8
Pavlov. Cond. change in total contacts9.610.412.4-3.53.43.4-3.2-3.33.4-3.2-3.3-3.3-3.33.3-3.13.22.72.6
Pavlov. Cond. index score8.811.112.9-3.63.43.1-3.5-3.43.0-3.5-3.4-3.4-3.53.4-3.32.13.53.5
Pavlov. Cond. latency score6.88.710.7-3.23.02.7-3.1-2.92.6-3.1-3.1-3.1-3.13.0-2.91.73.13.3
Pavlov. Cond. lever contacts3.34.05.4-2.21.91.7-2.0-2.01.6-2.1-2.2-2.2-2.12.1-2.00.72.32.3
Pavlov. Cond. magazine entry number13.116.619.34.3-4.3-4.14.44.2-4.04.24.14.14.3-4.13.9-3.3-3.9-4.0
Pavlov. Cond. intertrial magazine entries1.31.62.51.4-1.3-1.21.31.1-1.11.01.11.11.5-1.31.2-1.0-1.5-1.6
Pavlov. Cond. lever-magazine prob. diff.10.412.915.1-3.93.73.4-3.8-3.63.3-3.7-3.7-3.7-3.83.7-3.62.43.73.7
Pavlov. Cond. response bias10.713.415.0-3.93.93.6-3.8-3.73.5-3.7-3.7-3.7-3.83.7-3.62.93.63.6
Pavlov. Cond. lever latency0.40.51.00.8-0.6-0.70.70.7-0.70.50.50.50.8-0.90.9-0.4-1.0-0.7
Pavlov. Cond. magazine entry latency0.10.10.40.3-0.2-0.30.30.5-0.30.50.50.50.2-0.10.1-0.6-0.1-0.2
Pavlov. Cond. change in total contacts0.30.71.2-1.10.91.0-0.8-0.91.0-0.8-0.7-0.7-1.11.0-0.90.50.80.4
Pavlov. Cond. index score0.10.10.3-0.50.30.3-0.4-0.30.2-0.2-0.3-0.3-0.50.5-0.5-0.30.50.4
Pavlov. Cond. latency score0.10.10.2-0.40.20.2-0.3-0.20.1-0.1-0.2-0.2-0.40.4-0.4-0.40.40.3
Pavlov. Cond. lever contacts0.40.61.1-0.90.70.7-0.8-0.70.6-0.6-0.6-0.6-0.90.9-0.90.21.00.9
Pavlov. Cond. magazine entry number0.10.10.20.4-0.4-0.20.30.1-0.20.20.40.40.3-0.30.30.1-0.3-0.3
Pavlov. Cond. intertrial magazine entries1.12.43.71.8-1.5-1.11.51.5-1.11.81.81.81.5-1.51.3-0.4-1.7-1.9
Pavlov. Cond. lever-magazine prob. diff.0.00.10.2-0.40.10.1-0.2-0.10.1-0.1-0.2-0.2-0.40.3-0.3-0.40.40.2
Pavlov. Cond. response bias0.81.11.8-1.21.11.0-1.0-1.01.0-0.9-0.9-0.9-1.21.3-1.20.61.31.1
Time in closed arm before self-admin1.52.65.0-1.81.41.7-1.6-1.71.6-1.5-2.2-2.2-1.81.4-1.31.31.11.0
Time in closed arm after self-admin0.10.10.50.2-0.2-0.10.40.30.00.4-0.3-0.30.0-0.50.40.4-0.7-0.6
Time in open arm before self-admin1.62.05.41.8-0.9-1.31.31.4-1.21.22.32.31.5-1.11.0-0.7-0.8-0.8
Time in open arm after self-admin0.40.40.90.8-0.3-0.50.70.6-0.50.51.01.00.9-0.40.4-0.4-0.5-0.5
Bone: periosteal estimation0.20.50.90.7-0.5-0.90.60.7-1.00.50.90.90.6-0.60.7-1.0-0.10.1
Bone: periosteal perimeter0.61.11.91.0-1.1-1.41.11.2-1.41.11.11.10.8-1.01.1-1.3-0.5-0.4
Bone: post-yield work0.91.62.11.3-1.3-1.41.31.4-1.41.40.80.81.2-1.31.4-1.0-1.1-1.1
Progressive ratio test 1 active lever presses0.10.10.5-0.00.70.3-0.6-0.40.3-0.60.30.3-0.20.2-0.10.10.10.3
Progressive ratio test 1 breakpoint0.10.10.30.10.60.2-0.5-0.30.2-0.50.40.4-0.10.1-0.00.1-0.00.2
Progressive ratio test 1 inactive lever presses0.10.30.7-0.40.60.5-0.1-0.50.7-0.4-0.5-0.5-0.50.6-0.50.80.30.2
Progressive ratio test 2 active lever presses0.60.81.3-0.81.11.0-0.7-1.11.1-1.0-0.2-0.2-1.11.1-1.10.70.80.6
Progressive ratio test 2 breakpoint0.70.91.4-0.81.21.1-0.8-1.11.1-1.1-0.2-0.2-1.11.1-1.10.70.90.7
Progressive ratio test 2 inactive lever presses0.00.10.3-0.30.20.40.0-0.40.5-0.5-0.0-0.0-0.50.5-0.40.20.20.1
Incentive Sensitization - Responses0.51.42.3-1.31.01.3-0.9-1.41.3-1.3-0.5-0.5-1.51.5-1.40.61.30.9
Incentive Sensitization - Breakpoint0.51.22.2-1.21.01.2-0.8-1.31.2-1.2-0.5-0.5-1.51.4-1.40.61.30.9
Sum of active levers in priming session hrs 5-60.20.20.7-0.00.80.2-0.5-0.40.3-0.8-0.3-0.3-0.20.1-0.10.40.40.9
Progressive ratio0.00.10.3-0.50.50.2-0.0-0.30.4-0.50.10.1-0.10.4-0.50.20.60.5
Food seeking constrained by brief footshock0.50.61.1-0.60.60.6-0.8-0.80.6-0.9-1.1-1.1-0.60.9-0.70.41.01.1
Seeking ratio, punishment vs. effort0.00.10.10.2-0.3-0.0-0.40.1-0.20.2-0.4-0.4-0.0-0.10.3-0.0-0.3-0.0
Retroperitoneal fat weight0.10.30.6-0.70.20.4-0.4-0.60.4-0.8-0.7-0.7-0.50.5-0.40.20.60.6
Reaction time number correct0.41.43.81.1-1.0-1.21.11.3-1.11.32.02.00.8-0.91.1-1.0-0.7-0.8
Reaction time mean minus median0.10.61.20.7-1.1-0.70.60.8-0.80.8-0.0-0.00.9-0.70.5-0.9-0.8-1.0
Reaction time mean minus median AUC0.00.10.20.0-0.3-0.1-0.30.2-0.30.1-0.5-0.50.3-0.20.1-0.3-0.3-0.3
Reaction time num false alarms0.40.71.9-0.81.10.6-1.0-0.70.5-0.9-0.5-0.5-0.90.7-0.9-0.11.21.4
Reaction time num false alarms AUC0.20.51.4-0.60.70.5-0.8-0.50.4-0.6-0.4-0.4-0.70.7-0.9-0.21.21.2
Reaction time trials correct on left0.41.43.81.1-1.0-1.21.11.3-1.11.32.02.00.8-0.91.1-1.0-0.7-0.8
Reaction time trials on left0.41.43.61.0-1.0-1.11.11.3-1.11.21.91.90.8-0.91.0-0.9-0.7-0.8
Reaction time mean0.10.30.9-0.40.20.7-0.1-0.40.8-0.0-0.8-0.8-0.20.6-0.71.00.1-0.2
Reaction time mean AUC0.10.31.1-0.40.30.7-0.1-0.40.8-0.0-0.8-0.8-0.20.6-0.71.10.1-0.2
Median of all reaction times0.81.22.7-1.00.91.4-0.6-1.11.5-0.6-1.1-1.1-0.91.2-1.41.60.70.4
Reaction time omissions0.40.61.3-0.90.40.8-0.5-0.50.8-0.3-1.1-1.1-0.80.8-0.90.70.70.5
Reaction time false alarm rate1.01.42.2-1.11.21.0-1.3-1.10.9-1.1-1.3-1.3-1.11.1-1.30.41.41.5
Reaction time premature initiation rate0.30.51.4-0.10.90.8-0.5-0.50.9-0.2-0.3-0.3-0.30.8-0.91.20.80.8
Reaction time premature initiations0.10.31.00.80.0-0.10.40.50.00.71.01.00.4-0.00.00.40.10.1
Std. dev. reaction times0.00.10.4-0.0-0.4-0.00.10.2-0.10.3-0.6-0.60.30.0-0.1-0.1-0.2-0.4
Reaction time trials completed0.41.43.61.0-1.0-1.11.11.3-1.11.21.91.90.8-0.91.0-0.9-0.7-0.8
Reaction time trials AUC0.41.33.71.0-0.9-1.11.01.3-1.01.21.91.90.8-0.81.0-0.9-0.7-0.8
Run reversals in cocaine runway, females1.82.03.31.7-1.0-1.11.31.4-0.91.31.81.81.4-1.41.5-0.3-1.8-1.5
Run reversals in cocaine runway, males0.20.20.5-0.60.30.5-0.6-0.50.4-0.70.00.0-0.50.4-0.30.20.20.4
Latency to leave start box in cocaine runway1.21.62.60.9-1.3-1.31.61.3-1.11.31.51.50.8-1.21.4-0.7-1.3-1.4
Latency to leave start box in cocaine runway, F2.12.75.61.5-1.3-1.51.91.7-1.41.82.42.41.2-1.41.6-0.9-1.6-1.5
Latency to leave start box in cocaine runway, M0.20.20.7-0.8-0.00.30.0-0.40.4-0.5-0.8-0.8-0.50.3-0.20.50.1-0.1
Std. dev. time between licks in bursts0.10.10.30.3-0.6-0.40.40.3-0.40.5-0.0-0.00.2-0.10.1-0.40.2-0.1
Total sessions with >9 infusions0.10.20.5-0.30.70.5-0.1-0.40.7-0.3-0.2-0.2-0.40.3-0.20.7-0.2-0.1
Short access day 1 total inactive lever presses1.02.13.6-1.81.11.5-1.1-1.31.6-1.1-1.9-1.9-1.81.5-1.21.21.01.2
Short access day 10 total inactive lever presses0.00.20.70.1-0.8-0.00.90.20.00.5-0.5-0.50.20.2-0.20.2-0.0-0.5
Short access day 1 total infusions0.30.51.3-0.81.00.8-0.3-0.81.0-0.8-0.5-0.5-0.80.6-0.31.1-0.00.5
Short access day 10 total infusions0.20.41.0-0.41.00.7-0.6-0.60.8-0.6-0.2-0.2-0.90.6-0.50.60.40.5
Short access total infusions0.20.31.0-0.41.00.7-0.1-0.60.9-0.5-0.1-0.1-0.70.6-0.40.90.20.4
Short access day 1 locomotion0.91.52.2-1.31.21.2-1.0-1.31.3-1.4-1.5-1.5-1.31.0-0.81.20.81.1
Short access day 10 total locomotion0.52.23.8-1.71.21.4-1.9-1.71.2-1.9-1.4-1.4-1.71.3-1.30.51.41.4
Short access total locomotion0.20.30.9-0.80.50.6-0.6-0.80.5-0.9-0.6-0.6-0.80.4-0.30.20.40.5
One hour access (0.3 mA shock)0.30.41.10.8-0.1-0.40.30.5-0.40.61.01.00.6-0.50.4-0.3-0.7-0.7
Compulsive drug intake0.20.31.50.40.1-0.1-0.20.2-0.10.00.40.40.5-0.40.30.3-1.2-1.1
One hour access (shock baseline)0.00.00.20.30.1-0.00.50.20.10.30.30.3-0.00.1-0.00.10.20.1
Social response proportion0.20.20.80.2-0.1-0.60.20.5-0.60.1-0.3-0.30.6-0.70.9-0.6-0.6-0.2
Social responses0.40.51.9-0.90.4-0.1-0.4-0.4-0.1-0.8-1.4-1.4-0.20.0-0.1-0.60.50.8
Social time0.10.21.2-0.4-0.5-0.50.10.3-0.60.1-0.1-0.10.2-0.10.0-1.10.40.5
Soleus weight0.10.31.50.20.1-0.5-0.6-0.0-0.6-0.5-0.4-0.40.3-0.10.2-1.20.61.1
Bone: stiffness0.00.10.40.20.5-0.1-0.10.10.0-0.00.30.3-0.0-0.10.10.20.30.7
Tibialis anterior weight1.45.06.52.3-2.2-2.52.22.5-2.52.32.02.02.4-2.32.3-2.3-2.0-1.5
Time to tail flick, vehicle, before self-admin0.20.21.0-0.5-0.6-0.1-0.4-0.1-0.3-0.0-1.0-1.0-0.30.1-0.0-0.70.20.1
Time to tail flick, vehicle, after self-admin0.00.10.40.10.20.1-0.2-0.1-0.0-0.00.40.40.10.3-0.5-0.20.60.3
Time to tail flick, test, before self-admin1.01.12.31.3-1.1-1.10.81.1-1.11.20.90.91.5-1.00.8-1.1-0.8-0.8
Time to tail flick, test, after self-admin0.30.31.2-0.6-0.2-0.1-0.3-0.4-0.2-0.7-1.1-1.1-0.40.2-0.2-0.70.50.6
Delta time to tail flick, vehicle, before/after SA0.40.41.4-0.10.90.4-0.6-0.60.4-0.70.50.5-0.30.7-0.90.21.21.0
Delta time to tail flick, test, before/after SA2.22.75.0-2.21.41.4-1.5-1.81.4-2.2-1.7-1.7-2.01.5-1.30.91.51.5
Tibia length1.43.86.11.8-1.8-2.41.62.2-2.51.71.81.82.0-2.12.3-2.3-1.6-0.9
Ambulatory time before self-admin0.00.10.40.00.10.00.7-0.00.20.20.40.4-0.40.3-0.20.20.2-0.1
Ambulatory time after self-admin1.01.62.71.6-1.6-1.51.61.3-1.41.40.60.61.0-1.21.3-1.5-1.0-0.8
Bone: tissue strength1.41.51.81.4-1.3-1.31.11.3-1.31.20.90.91.2-1.31.3-1.0-1.2-1.3
Total heroin consumption2.42.86.1-1.41.51.5-1.2-1.51.5-1.5-1.2-1.2-2.02.1-1.81.32.52.1
Bone: trabecular number5.29.712.6-3.33.22.9-3.2-3.02.9-3.0-3.4-3.4-3.13.0-3.02.53.33.6
Bone: trabecular spacing1.82.64.51.7-1.6-1.91.41.7-1.91.51.71.71.5-1.51.5-2.1-1.2-1.0
Bone: trabecular thickness0.10.20.5-0.70.00.2-0.2-0.20.2-0.1-0.6-0.6-0.30.3-0.30.30.40.4
Bone: trabecular tissue density0.10.21.00.3-0.10.20.20.00.2-0.00.20.20.6-0.30.30.6-0.8-1.0
Water consumed over 24 hours0.10.30.90.7-0.7-0.50.30.5-0.60.40.60.60.1-0.20.5-0.9-0.2-0.2
Number of responses in last shaping day0.20.30.8-0.50.10.50.0-0.50.6-0.4-0.9-0.9-0.50.4-0.30.6-0.2-0.2