Hub : Genes

RT1-M5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	RT1-M5	0.09	0.05	4.7e-12	0.12	0.11	0.1	0.1	1.3e-12	1.3e-11	2.6e-11	2.1e-11
2	IC	gene expression	RT1-M5	0.09	0.06	6.2e-03	0.05	0.04	0.03	0.04	3.0e-03	9.5e-03	1.6e-02	1.1e-02
3	Adipose	gene expression	RT1-M5	0.05	0.03	1.9e-05	0.04	0.04	0.04	0.04	3.0e-05	1.1e-05	2.1e-05	2.0e-05
4	Brain	gene expression	RT1-M5	0.05	0.03	9.0e-04	0.04	0.02	0.03	0.03	1.3e-04	2.6e-03	8.7e-04	6.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.4	2.5	3.0	1.5	1.7	-1.6	1.5
Area under the delay curve	1.9	2.2	3.3	-1.8	-1.5	1.6	-0.7
BMI with tail	1.6	5.5	8.0	-1.8	-2.2	2.4	-2.8
BMI without tail	2.7	8.2	9.4	-2.8	-2.9	3.1	-2.6
Body weight	5.1	22.4	30.4	-5.4	-5.5	4.7	-2.9
Weight adjusted by age	1.8	2.7	6.9	-1.6	-2.6	1.1	0.5
Bone surface	0.3	0.6	2.0	-0.4	-0.2	-0.4	1.4
Bone volume	0.2	0.4	1.5	-0.2	-0.0	-0.4	1.2
Breakpoint value in progressive ratio session	0.5	0.6	1.2	1.0	0.5	-0.2	-1.1
Number of licking bursts	0.0	0.0	0.0	-0.2	-0.0	0.0	-0.2
Context. condit. distance diff. score	5.2	6.3	8.0	2.2	2.4	-2.8	2.5
Locomotion velocity, session 1	0.2	0.2	0.3	0.2	0.3	-0.5	0.6
Locomotion distance, session 1	0.6	0.7	1.2	1.1	1.1	-0.7	0.3
Locomotion velocity, session 2	0.4	0.4	1.3	-0.3	-0.2	0.6	-1.1
Locomotion distance, session 2	0.7	1.0	1.2	1.1	1.0	-1.0	0.9
Locomotion velocity, session 3	0.5	0.6	1.8	-0.0	0.1	0.7	-1.3
Locomotion distance, session 3	1.3	1.4	2.0	1.4	1.4	-1.2	0.5
Stereotopy head waving bouts, day 3	0.8	0.9	1.6	-1.3	-1.0	0.8	-0.6
Stereotopy head waving duration, day 3	0.8	0.9	1.6	-1.3	-1.0	1.0	-0.6
Locomotion velocity, session 7	3.9	4.3	4.5	2.1	2.1	-2.1	2.0
Locomotion distance, session 7	3.1	3.9	4.1	2.0	2.0	-2.0	1.8
Stereotopy head waving bouts, day 7	1.7	1.9	2.9	-1.7	-1.5	1.5	-0.7
Stereotopy head waving duration, day 7	1.8	2.2	3.1	-1.8	-1.6	1.6	-0.9
Locomotion velocity, session 8	0.3	0.4	1.2	-0.4	-0.4	-0.4	1.1
Locomotion distance, session 8	3.7	5.3	6.6	2.2	1.9	-2.6	2.5
Degree of sensitization distance	0.3	0.3	0.9	-0.1	0.1	-0.4	0.9
Degree of sensitization stereotypy	0.6	0.7	1.0	-1.0	-0.8	0.9	-0.5
Conditioned locomotion	2.9	3.3	3.7	-1.7	-1.7	1.9	-1.9
Cocaine response after cond. corrected	0.3	0.4	0.9	0.6	0.6	0.2	-1.0
Cocaine response after cond. not corrected	0.4	0.5	0.6	-0.7	-0.5	0.8	-0.8
Cocaine response before conditioning	3.7	4.5	8.0	-2.8	-2.7	1.6	0.2
Saline control response	1.0	1.4	1.8	-1.2	-1.3	1.3	-0.8
Bone: connectivity density	2.9	4.5	5.1	1.8	2.2	-2.3	2.2
Bone: cortical apparent density	0.5	0.7	1.0	-0.5	-0.7	1.0	-1.0
Bone: cortical area	0.6	0.9	2.3	-1.0	-1.5	0.7	0.3
Bone: cortical porosity	0.1	0.1	0.1	-0.4	-0.3	0.3	-0.0
Bone: cortical porosity	0.2	0.2	0.2	-0.4	-0.5	0.1	0.5
Bone: cortical thickness	1.1	1.8	2.6	-1.1	-1.6	1.5	-1.1
Bone: cortical thickness	0.5	0.6	1.4	-0.2	-0.6	0.9	-1.2
Bone: cortical tissue density	0.4	0.6	0.9	-0.5	-0.6	0.9	-1.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.4	0.4	-0.3	0.1
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.5	-0.8	-0.5	0.9	-1.2
Condit. Reinf. active responses	0.5	0.6	1.3	1.1	0.8	-0.7	0.3
Condit. Reinf. inactive responses	2.3	2.8	5.1	2.3	1.6	-1.6	1.0
Incentive salience index mean	0.4	0.5	0.7	0.8	0.8	-0.8	0.2
Condit. Reinf. lever presses	1.9	2.6	4.0	2.0	1.6	-1.8	0.7
Condit. Reinf. active minus inactive responses	0.4	0.5	1.0	-0.8	-1.0	0.7	0.0
Condit. Reinf. active-inactive response ratio	1.5	1.7	2.3	-1.5	-1.5	1.3	-0.7
Condit. Reinf. active responses	0.3	0.4	0.8	0.6	0.3	-0.6	0.9
Condit. Reinf. inactive responses	1.3	1.6	2.1	1.4	1.2	-1.3	1.1
Condit. Reinf. lever presses	2.5	3.4	4.6	1.8	1.4	-1.9	2.2
Condit. Reinf. lever reinforcers received	0.5	0.7	1.2	0.7	0.6	-0.8	1.1
Conditioned reinforcement - actives	0.5	0.9	1.6	-1.1	-1.3	0.9	-0.1
Conditioned reinforcement - inactives	0.5	0.7	2.0	-0.6	-1.4	0.6	-0.2
Conditioned locomotion	0.2	0.3	0.5	-0.7	-0.6	0.4	-0.4
Patch foraging indifference point 0 sec	0.3	0.6	2.1	0.0	0.4	-0.6	1.4
Patch foraging indifference point AUC	0.9	1.3	2.4	-1.2	-1.6	1.1	-0.2
Delay disc. indifference point, 0s delay	0.8	0.9	1.3	-0.9	-0.6	1.1	-1.0
Delay disc. indifference point, 16s delay	1.1	1.2	1.6	-1.2	-1.1	1.3	-0.7
Delay disc. indifference point, 2s delay	2.1	2.3	2.8	-1.7	-1.6	1.6	-1.1
Delay disc. indifference point, 24s delay	0.5	0.6	1.1	-1.0	-0.8	0.8	-0.0
Delay disc. indifference point, 4s delay	3.4	3.6	4.6	-2.1	-2.1	2.0	-1.2
Delay disc. indifference point, 8s delay	0.3	0.4	0.8	-0.9	-0.7	0.3	0.4
Indifference point function ln k	0.3	0.6	1.0	0.6	0.2	-1.0	1.0
Indifference point function log k	0.3	0.6	1.0	0.6	0.2	-1.0	1.0
Patch foraging total patch changes 0 sec	0.3	0.6	2.1	-0.1	0.3	-0.4	1.4
Patch foraging total patch changes 12 sec	0.1	0.2	0.6	-0.1	-0.2	0.1	0.8
Patch foraging total patch changes 18 sec	0.3	0.4	0.9	0.5	0.9	-0.6	0.5
Patch foraging total patch changes 24 sec	0.5	0.8	1.3	0.7	0.9	-0.7	1.2
Patch foraging total patch changes 6 sec	0.2	0.3	0.6	-0.7	-0.3	0.6	0.4
Patch foraging time to switch 0 sec	0.5	0.9	3.1	-0.0	0.6	0.5	-1.8
Patch foraging water rate 0 sec	0.5	1.1	3.9	-0.2	-0.6	-0.4	2.0
Patch foraging water rate 12 sec	0.0	0.1	0.2	0.4	0.1	-0.2	0.3
Patch foraging water rate 18 sec	0.1	0.1	0.3	0.2	-0.0	-0.0	0.5
Patch foraging water rate 24 sec	0.2	0.3	0.5	-0.7	-0.3	0.6	-0.1
Patch foraging water rate 6 sec	0.0	0.1	0.2	0.4	0.3	-0.2	0.1
Seeking ratio, delayed vs. immediate footshock	0.7	0.9	1.8	-0.6	-0.7	0.9	-1.3
Distance traveled before self-admin	0.2	0.3	0.8	0.3	0.1	-0.6	0.9
Distance traveled after self-admin	0.2	0.2	0.5	-0.7	-0.4	0.4	-0.3
Extensor digitorum longus weight	0.5	1.9	6.1	0.0	0.2	-1.1	2.5
Bone: elastic displacement	0.4	0.5	0.7	-0.7	-0.2	0.8	-0.9
Bone: elastic work	1.0	1.3	1.6	-1.3	-0.9	1.2	-1.2
Bone: endosteal estimation	1.3	2.7	5.7	-2.4	-2.0	1.0	0.4
Bone: endosteal perimeter	0.5	1.1	3.4	-0.3	-0.2	-1.0	1.8
Epididymis fat weight	1.1	3.8	8.4	-0.9	-0.7	2.3	-2.9
Delta time in closed arm before/after self-admin	0.4	0.4	0.7	-0.6	-0.8	0.6	-0.2
Delta time in open arm before/after self-admin	0.3	0.3	1.1	-0.2	-0.0	-0.3	1.1
Diff in mean of infusions in LGA sessions	2.1	2.5	4.7	2.2	1.8	-1.5	0.1
Delay discount exponential model param	2.0	2.3	3.4	1.8	1.6	-1.6	0.8
Extinction: sum of active levers before priming	0.8	0.8	1.9	1.4	0.8	-0.7	-0.7
Active lever presses in extinction session 6	0.9	0.9	3.0	0.5	0.1	0.6	-1.7
Bone: final force	2.0	3.1	4.3	-1.9	-2.1	1.9	-1.1
Bone: final moment	1.4	2.2	3.5	-1.7	-1.9	1.5	-0.5
Food consumed during 24 hour testing period	0.4	0.6	0.8	-0.9	-0.8	0.7	-0.7
Glucose	2.0	3.1	6.0	0.9	1.2	-2.1	2.4
Heart weight	2.2	3.5	5.7	-2.3	-2.4	1.7	-0.3
Delay discount hyperbolic model param	2.1	2.4	3.3	1.8	1.6	-1.7	0.9
Intermittent access intake day 1-15 change	0.0	0.1	0.3	-0.0	-0.0	0.1	-0.5
Intermittent access intake escalation	0.3	0.6	1.3	-0.6	-0.5	0.8	-1.1
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.2	-0.3	-0.2	0.6
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.0	-0.3	-0.2	-0.2
Intermitt. access day 15 inactive lever presses	0.2	0.4	0.9	-0.9	-0.6	0.5	0.0
Intermitt. access escalation Index	1.2	1.7	3.2	1.8	1.4	-1.0	-0.9
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.3	0.0	0.1	0.0
Intermittent access day 15 total infusions	0.6	0.9	1.5	-0.7	-0.5	1.2	-1.2
Intermittent access terminal intake (last 3 days)	0.5	0.6	1.2	-0.8	-0.6	1.1	-0.6
Intermittent access total infusions	0.3	0.4	0.8	-0.6	-0.5	0.9	-0.4
Intermittent access day 1 locomotion	0.4	0.5	1.0	-0.5	-0.5	0.8	-1.0
Intermittent access day 15 total locomotion	2.1	3.8	4.4	-2.0	-2.0	2.1	-1.6
Intermittent access total locomotion	2.7	3.2	3.8	-1.9	-1.9	1.9	-1.5
Intermittent access standard deviation	0.6	1.3	2.7	-1.2	-1.6	0.9	0.5
Left kidney weight	2.4	11.1	16.4	-4.0	-3.9	3.3	-1.4
Right kidney weight	3.4	15.6	22.4	-4.7	-4.7	3.9	-1.7
Cocaine induced anxiety	0.5	0.7	1.0	0.7	0.9	-1.0	0.8
Post-drug Anxiety	0.6	0.6	0.8	0.9	0.4	-0.8	0.8
Baseline Anxiety	0.3	0.3	0.9	1.0	0.2	-0.2	-0.5
Tail length	2.3	9.0	15.6	-3.9	-3.7	2.6	-0.3
Length with tail	3.1	13.4	23.3	-4.8	-4.7	2.9	0.4
Length without tail	3.3	10.7	16.7	-4.0	-4.1	3.0	-1.0
Times rat made contact with spout	1.1	1.3	2.3	1.5	1.5	-0.9	-0.1
Lifetime Intake	0.5	0.6	1.0	-0.8	-0.9	1.0	-0.3
Liver weight, left	0.3	0.5	1.0	-0.8	-1.0	0.2	0.3
Liver weight, right	2.1	3.7	6.6	-2.6	-2.3	1.6	-0.7
Locomotor activity	0.5	0.8	2.3	-0.8	-0.5	-0.3	1.5
Locomotor testing distance	0.5	1.0	2.7	-0.2	0.6	-0.9	1.6
Locomotor testing rearing	0.1	0.3	0.6	-0.6	0.0	-0.2	0.8
Locomotion in novel chamber	0.1	0.1	0.3	-0.4	-0.4	0.1	0.5
Locomotion in novel chamber post-restriction	0.5	0.8	1.4	-0.9	-1.2	1.0	-0.3
Fecal boli incidents, locomotor time 1	1.0	1.5	2.4	1.3	1.5	-1.0	0.9
Change in fecal boli incidents, locomotor task	2.6	2.6	3.0	-1.4	-1.7	1.6	-1.6
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.2	-1.1	-0.6	0.8	-0.6
Bouts of movement, locomotor time 1	1.4	1.6	3.6	0.8	0.7	-1.3	1.9
Total resting periods, locomotor time 1	0.5	0.6	1.5	0.5	0.4	-0.7	1.2
Rest time, locomotor task time 1	0.3	0.4	0.5	-0.7	-0.7	0.7	-0.5
Distance moved, locomotor task time 1	0.1	0.2	0.4	-0.2	-0.4	-0.1	0.7
Vertical activity count, locomotor time 1	0.1	0.2	0.5	0.0	-0.4	-0.3	0.7
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.8	-0.8	-0.9	0.4	0.3
Bouts of movement, locomotor time 2	0.2	0.4	0.7	-0.8	-0.7	0.4	0.4
Total resting periods, locomotor time 2	0.2	0.3	0.4	-0.6	-0.6	0.1	0.6
Rest time, locomotor task time 2	0.1	0.1	0.2	0.3	0.3	-0.4	0.3
Distance moved, locomotor task time 2	0.2	0.3	0.4	-0.6	-0.6	0.6	0.1
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.0	-0.3	-0.1	0.3
Light reinforcement 1	0.0	0.0	0.1	-0.0	-0.0	0.3	-0.2
Light reinforcement 2	1.4	2.2	3.1	-1.7	-1.8	1.5	-0.5
Bone: marrow area	1.2	2.7	5.6	-2.4	-2.0	1.0	0.3
Bone: maximum diameter	0.4	0.7	2.1	-0.3	-0.4	-0.6	1.5
Bone: maximum force	1.6	2.8	4.2	-2.0	-2.0	1.6	-0.7
Bone: maximum moment	1.1	2.0	3.4	-1.8	-1.9	1.2	0.0
Mean time between licks in bursts	0.1	0.3	1.0	-0.1	-0.1	-0.6	1.0
Mean num. licks in bursts	0.2	0.4	0.8	0.9	0.7	-0.5	0.1
Cd content in liver	0.1	0.1	0.4	0.1	-0.0	-0.2	0.6
Co content in liver	0.3	0.3	0.5	-0.4	-0.6	0.7	-0.4
Cu content in liver	0.8	0.9	1.6	1.3	1.1	-0.9	0.4
Fe content in liver	1.4	1.7	3.5	-0.9	-0.8	1.5	-1.9
K content in liver	0.5	0.5	0.8	0.8	0.9	-0.7	0.2
Mg content in liver	0.7	0.7	1.1	0.8	0.8	-1.0	0.7
Mn content in liver	1.7	1.9	2.6	1.3	1.4	-1.6	1.2
Na content in liver	0.1	0.1	0.3	-0.3	0.0	0.3	-0.6
Rb content in liver	0.6	0.7	0.9	0.8	0.7	-1.0	0.8
Se content in liver	0.1	0.1	0.2	-0.3	-0.2	-0.2	0.5
Sr content in liver	0.6	0.6	1.0	-0.6	-1.0	0.6	-0.7
Zn content in liver	0.7	0.7	1.6	0.5	0.4	-0.9	1.3
Bone: minimum diameter	0.2	0.4	0.8	-0.5	-0.6	-0.3	0.9
Time in familiar zone, hab. session 1	1.4	1.3	2.8	1.3	1.7	-0.9	-0.1
Time in novel zone, hab. session 1	1.3	1.3	2.2	-1.0	-1.3	0.2	1.5
Total zone transitions, hab. session 1	0.9	1.3	1.5	1.2	1.1	-1.2	1.1
Total locomotion distance, hab. session 1	0.5	0.7	0.9	0.9	1.0	-0.9	0.6
Locomotion velocity, hab. session 1	0.2	0.3	0.6	0.8	0.7	-0.5	-0.0
Time in familiar zone, hab. session 2	0.5	0.6	1.0	0.9	1.0	-0.6	-0.1
Time in novel zone, hab. session 2	0.6	0.6	1.1	-1.0	-1.1	0.7	0.2
Total zone transitions, hab. session 2	0.0	0.0	0.1	0.2	0.1	0.0	-0.3
Total locomotion distance, hab. session 2	0.7	1.0	1.6	1.2	1.3	-0.9	0.4
Locomotion velocity, hab. session 2	0.9	1.2	1.8	1.3	1.3	-1.0	0.4
Novel to familiar place preference ratio	0.2	0.2	0.3	-0.5	-0.5	0.4	0.0
Novelty place preference	0.4	0.4	0.7	-0.8	-0.8	0.6	-0.0
Time in novel zone, NPP test	0.6	0.7	1.1	-1.0	-1.0	0.7	-0.0
Total zone transitions, NPP test	1.3	1.9	2.5	1.0	1.4	-1.5	1.6
Total locomotion distance, NPP test	0.9	1.2	1.8	1.0	1.3	-1.0	0.9
Locomotion velocity, NPP test	1.5	2.2	3.3	1.6	1.8	-1.4	1.0
Intraocular pressure	0.8	1.2	1.4	1.1	0.9	-1.1	1.2
Delta distance traveled before/after self-admin	1.8	1.9	2.9	-1.7	-1.0	1.5	-1.2
Delta ambulatory time before/after self-admin	1.2	1.4	2.1	-1.4	-0.9	1.3	-1.1
Parametrial fat weight	0.8	1.9	2.7	-1.4	-1.7	1.4	-0.9
Pavlov. Cond. lever latency	0.3	0.3	0.6	-0.2	-0.5	0.7	-0.8
Pavlov. Cond. magazine entry latency	0.9	1.1	1.6	1.3	1.1	-1.2	0.3
Pavlov. Cond. change in total contacts	0.6	0.6	1.2	-1.1	-0.8	0.6	-0.3
Pavlov. Cond. index score	0.5	0.6	0.9	0.8	0.9	-1.0	0.3
Pavlov. Cond. latency score	0.3	0.4	0.7	0.6	0.7	-0.8	0.3
Pavlov. Cond. lever contacts	0.2	0.2	0.3	0.1	0.4	-0.6	0.6
Pavlov. Cond. magazine entry number	1.1	1.4	2.1	-1.4	-1.4	1.2	0.0
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	0.7	0.4	-0.3	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.2	1.0	1.1	-1.1	0.3
Pavlov. Cond. response bias	0.6	0.7	1.1	0.9	1.0	-1.0	0.2
Pavlov. Cond. lever latency	0.8	1.0	1.5	-1.0	-0.8	1.0	-1.2
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	-0.6	-0.5	0.4	-0.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.3	-0.5	0.2	0.2
Pavlov. Cond. index score	0.1	0.1	0.5	0.1	0.0	-0.3	0.7
Pavlov. Cond. latency score	0.0	0.0	0.2	0.0	-0.1	-0.2	0.4
Pavlov. Cond. lever contacts	0.5	0.7	1.2	0.7	0.5	-0.8	1.1
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.6	0.5	-0.4	-0.0
Pavlov. Cond. intertrial magazine entries	0.4	0.6	0.8	0.9	0.7	-0.9	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.6	0.1	0.2	-0.4	0.8
Pavlov. Cond. response bias	0.4	0.5	1.2	0.4	0.4	-0.7	1.1
Time in closed arm before self-admin	0.1	0.1	0.4	-0.1	-0.0	0.2	-0.6
Time in closed arm after self-admin	2.3	2.4	2.9	-1.4	-1.5	1.6	-1.7
Time in open arm before self-admin	0.2	0.2	0.6	0.8	0.0	-0.5	0.1
Time in open arm after self-admin	1.1	1.3	1.8	1.1	0.7	-1.2	1.3
Bone: periosteal estimation	1.2	2.6	4.7	-2.1	-2.2	1.0	0.4
Bone: periosteal perimeter	0.5	0.8	1.5	-1.0	-1.2	0.1	0.8
Bone: post-yield work	1.4	2.1	6.0	0.3	0.1	-1.5	2.5
Progressive ratio test 1 active lever presses	0.6	0.8	1.5	-0.4	-0.6	1.0	-1.2
Progressive ratio test 1 breakpoint	0.7	0.8	1.4	-0.5	-0.7	1.0	-1.2
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.3	-0.5	0.1	-0.5
Progressive ratio test 2 active lever presses	0.2	0.2	0.6	0.2	0.2	0.6	-0.7
Progressive ratio test 2 breakpoint	0.3	0.3	0.8	0.1	0.1	0.7	-0.9
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.6	-0.4	-0.8	0.6	-0.1
Incentive Sensitization - Responses	0.3	0.4	0.8	0.9	0.8	-0.2	-0.2
Incentive Sensitization - Breakpoint	0.3	0.4	0.8	0.9	0.8	-0.2	-0.2
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	0.5	0.7	-0.4	0.1
Progressive ratio	4.7	7.3	8.8	-2.3	-2.6	2.9	-3.0
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.3	0.1	-0.2	0.5
Seeking ratio, punishment vs. effort	4.1	5.9	8.1	2.1	2.1	-2.6	2.8
Retroperitoneal fat weight	0.5	2.2	3.7	-1.6	-1.9	1.4	-0.6
Reaction time number correct	0.2	0.4	0.7	-0.5	-0.4	0.8	-0.7
Reaction time mean minus median	0.2	0.5	1.2	-0.1	-0.2	-0.7	1.1
Reaction time mean minus median AUC	0.3	0.6	1.8	-0.0	-0.4	-0.8	1.3
Reaction time num false alarms	0.0	0.1	0.2	-0.4	-0.2	0.1	0.0
Reaction time num false alarms AUC	0.0	0.1	0.2	-0.4	-0.1	0.0	0.2
Reaction time trials correct on left	0.2	0.4	0.7	-0.5	-0.4	0.8	-0.7
Reaction time trials on left	0.2	0.4	0.7	-0.5	-0.5	0.8	-0.7
Reaction time mean	1.1	1.7	3.7	0.5	0.7	-1.5	1.9
Reaction time mean AUC	0.9	1.5	3.7	0.4	0.6	-1.4	1.9
Median of all reaction times	1.2	1.6	3.2	0.6	0.9	-1.5	1.8
Reaction time omissions	0.0	0.1	0.1	-0.1	0.3	-0.3	0.2
Reaction time false alarm rate	0.2	0.2	0.6	-0.1	0.1	-0.5	0.8
Reaction time premature initiation rate	0.5	0.7	1.0	-0.8	-0.8	1.0	-0.7
Reaction time premature initiations	0.9	1.6	2.4	-1.2	-1.0	1.6	-1.2
Std. dev. reaction times	0.3	0.6	1.8	-0.1	-0.1	-0.8	1.3
Reaction time trials completed	0.2	0.4	0.7	-0.5	-0.5	0.8	-0.7
Reaction time trials AUC	0.2	0.4	0.6	-0.5	-0.4	0.8	-0.7
Run reversals in cocaine runway, females	0.5	0.5	0.9	0.6	0.3	-0.7	1.0
Run reversals in cocaine runway, males	0.7	0.7	1.7	-1.3	-1.0	0.6	0.1
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.0	-0.0	0.4	-0.5
Latency to leave start box in cocaine runway, F	0.6	0.7	1.0	1.0	0.7	-0.7	0.9
Latency to leave start box in cocaine runway, M	3.1	2.9	3.7	-1.5	-1.4	1.9	-1.9
Std. dev. time between licks in bursts	0.2	0.2	0.7	-0.1	-0.2	-0.4	0.9
Total sessions with >9 infusions	0.6	0.8	1.0	-0.8	-1.0	1.0	-0.7
Short access day 1 total inactive lever presses	0.7	1.0	2.5	-0.9	-1.6	0.7	-0.1
Short access day 10 total inactive lever presses	0.7	1.7	2.9	1.7	1.0	-1.6	0.4
Short access day 1 total infusions	0.1	0.2	0.7	0.0	-0.2	-0.1	0.8
Short access day 10 total infusions	0.4	0.5	0.8	-0.7	-0.9	0.8	0.1
Short access total infusions	0.4	0.6	0.9	-0.8	-1.0	0.8	0.1
Short access day 1 locomotion	0.5	0.6	1.1	0.7	0.4	-0.8	1.1
Short access day 10 total locomotion	0.4	0.7	1.5	-0.9	-1.2	0.5	-0.2
Short access total locomotion	0.3	0.4	0.9	-0.6	-1.0	0.4	-0.3
One hour access (0.3 mA shock)	1.2	1.4	2.1	1.5	1.4	-1.2	0.6
Compulsive drug intake	2.8	3.3	5.4	2.1	2.3	-1.9	0.3
One hour access (shock baseline)	0.2	0.3	0.5	-0.6	-0.7	0.6	0.4
Social response proportion	0.2	0.3	0.8	0.1	0.3	-0.4	0.9
Social responses	0.1	0.1	0.1	-0.3	-0.2	0.4	-0.2
Social time	0.0	0.0	0.1	0.1	-0.0	-0.4	-0.1
Soleus weight	0.4	1.2	3.5	-0.5	0.3	-0.9	1.9
Bone: stiffness	0.3	0.4	0.6	-0.6	-0.8	0.7	-0.6
Tibialis anterior weight	0.0	0.1	0.2	0.1	0.5	0.1	-0.0
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.7	0.9	0.9	-0.6	-0.5
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.5	0.7	0.7	-0.6	-0.1
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.4	-0.2	0.2	-0.2
Time to tail flick, test, after self-admin	0.1	0.2	0.5	0.2	-0.7	-0.3	-0.2
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.0	0.0	-0.0	0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.3	0.3	-0.5	-0.0
Tibia length	1.5	4.1	6.5	-2.6	-2.5	1.7	-0.8
Ambulatory time before self-admin	0.1	0.1	0.3	0.3	0.1	-0.4	0.6
Ambulatory time after self-admin	0.3	0.3	0.5	-0.7	-0.3	0.6	-0.6
Bone: tissue strength	0.5	0.5	0.8	-0.9	-0.8	0.8	-0.3
Total heroin consumption	0.1	0.2	0.2	0.4	0.5	-0.4	0.3
Bone: trabecular number	0.8	1.3	2.0	1.1	1.4	-1.1	0.9
Bone: trabecular spacing	2.9	3.9	6.1	-2.0	-2.5	2.0	-1.3
Bone: trabecular thickness	1.5	1.9	2.7	1.4	1.7	-1.4	1.1
Bone: trabecular tissue density	0.9	1.3	2.1	-1.3	-1.4	1.1	-0.2
Water consumed over 24 hours	0.1	0.1	0.2	-0.2	-0.1	0.2	-0.5
Number of responses in last shaping day	0.4	0.4	1.0	-1.0	-0.7	0.2	0.3