Hub : Genes

RT1-Da

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	RT1-Da	0.15	0.06	2.7e-08	0.01	0.07	0.06	0.06	7.9e-03	4.4e-08	1.9e-07	9.0e-07
2	Liver	gene expression	RT1-Da	0.04	0.03	2.3e-03	0.01	0.03	0	0.01	7.1e-03	8.2e-04	2.7e-01	8.2e-03
3	Adipose	isoform ratio	NM_001008847.2	0.13	0.06	7.4e-13	0.12	0.11	0.1	0.06	5.5e-13	2.3e-12	1.2e-11	1.9e-07
4	Adipose	isoform ratio	XM_039098493.2	0.13	0.06	8.7e-13	0.12	0.11	0.1	0.07	5.5e-13	2.6e-12	1.3e-11	3.0e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.4	0.6	2.3	1.5	-0.2	0.2	-0.2
Area under the delay curve	0.1	0.1	0.5	-0.7	-0.1	0.1	-0.1
BMI with tail	2.7	9.5	11.1	2.3	3.2	-3.3	3.3
BMI without tail	1.6	4.8	6.4	1.1	2.5	-2.4	2.4
Body weight	1.9	8.5	11.6	0.2	3.3	-3.4	3.4
Weight adjusted by age	0.5	0.7	1.6	-1.3	0.6	-0.7	0.7
Bone surface	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.1
Bone volume	0.1	0.1	0.5	0.7	0.1	-0.2	0.2
Breakpoint value in progressive ratio session	0.2	0.2	0.3	-0.2	-0.5	0.5	-0.5
Number of licking bursts	0.9	1.4	2.0	-1.4	-1.1	1.1	-1.1
Context. condit. distance diff. score	4.6	5.5	7.0	-1.8	-2.7	2.4	-2.4
Locomotion velocity, session 1	3.1	3.3	4.0	-1.5	-2.0	1.9	-1.9
Locomotion distance, session 1	0.2	0.3	0.7	0.8	-0.5	0.4	-0.4
Locomotion velocity, session 2	0.5	0.5	0.7	-0.5	-0.8	0.8	-0.8
Locomotion distance, session 2	0.1	0.1	0.3	0.2	-0.5	0.4	-0.4
Locomotion velocity, session 3	0.2	0.2	0.7	0.8	0.4	-0.1	0.1
Locomotion distance, session 3	0.8	0.8	1.2	0.5	-0.9	1.1	-1.1
Stereotopy head waving bouts, day 3	0.4	0.5	1.8	-1.3	0.1	-0.2	0.2
Stereotopy head waving duration, day 3	0.3	0.4	1.6	-1.3	-0.0	-0.0	0.0
Locomotion velocity, session 7	0.7	0.7	1.5	0.3	-1.2	0.8	-0.8
Locomotion distance, session 7	2.0	2.5	3.9	0.1	-2.0	1.7	-1.7
Stereotopy head waving bouts, day 7	0.4	0.5	0.7	-0.5	-0.5	0.8	-0.8
Stereotopy head waving duration, day 7	0.0	0.0	0.1	-0.3	0.1	0.2	-0.2
Locomotion velocity, session 8	4.8	5.7	7.9	-2.8	-2.2	2.2	-2.2
Locomotion distance, session 8	2.5	3.6	5.1	-1.2	-2.3	2.0	-2.0
Degree of sensitization distance	0.6	0.7	1.4	-1.2	-0.8	0.5	-0.5
Degree of sensitization stereotypy	0.7	0.8	1.2	-0.1	-0.8	1.1	-1.1
Conditioned locomotion	0.6	0.7	1.0	-0.1	0.8	-1.0	1.0
Cocaine response after cond. corrected	0.3	0.3	0.6	0.3	0.4	-0.7	0.7
Cocaine response after cond. not corrected	0.2	0.2	0.5	-0.7	0.3	-0.4	0.4
Cocaine response before conditioning	0.5	0.6	2.1	-1.4	0.2	0.3	-0.3
Saline control response	2.6	3.4	4.9	1.6	2.2	-1.7	1.7
Bone: connectivity density	0.2	0.2	0.9	1.0	-0.1	-0.1	0.1
Bone: cortical apparent density	3.0	4.1	4.4	1.9	2.1	-2.1	2.1
Bone: cortical area	0.0	0.0	0.1	-0.2	0.3	-0.2	0.2
Bone: cortical porosity	2.4	2.6	3.4	-1.2	-1.5	1.9	-1.9
Bone: cortical porosity	3.5	3.8	4.4	-1.8	-1.8	2.1	-2.1
Bone: cortical thickness	1.5	2.5	4.0	2.0	1.6	-1.3	1.3
Bone: cortical thickness	4.0	4.7	5.6	2.4	2.3	-2.0	2.0
Bone: cortical tissue density	2.7	3.7	4.0	1.7	2.0	-2.0	2.0
Condit. Reinf. active minus inactive responses	1.2	1.3	1.8	-0.5	-1.1	1.3	-1.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.3	0.3	-0.1	0.1
Condit. Reinf. active responses	0.5	0.6	0.8	0.0	-0.8	0.9	-0.9
Condit. Reinf. inactive responses	0.3	0.4	1.2	1.1	-0.3	0.4	-0.4
Incentive salience index mean	2.1	2.6	3.1	-1.1	-1.7	1.7	-1.7
Condit. Reinf. lever presses	2.1	2.9	3.9	-1.4	-2.0	1.7	-1.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.8	-0.0	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.7	0.8	2.4	-1.6	-0.4	0.6	-0.6
Condit. Reinf. active responses	0.1	0.1	0.1	-0.2	-0.1	0.4	-0.4
Condit. Reinf. inactive responses	0.5	0.6	1.3	1.1	0.7	-0.6	0.6
Condit. Reinf. lever presses	0.9	1.3	1.9	-0.3	-1.1	1.4	-1.4
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	-0.4	-0.4	0.7	-0.7
Conditioned reinforcement - actives	0.0	0.0	0.1	0.3	0.0	-0.1	0.1
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.2	-0.2	0.1	-0.1
Conditioned locomotion	0.2	0.2	0.4	-0.6	-0.6	0.4	-0.4
Patch foraging indifference point 0 sec	1.3	2.4	3.5	1.1	1.9	-1.6	1.6
Patch foraging indifference point AUC	0.2	0.2	0.3	-0.5	-0.2	0.5	-0.5
Delay disc. indifference point, 0s delay	0.3	0.4	1.1	-1.0	-0.5	0.3	-0.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.5	0.3	-0.2	0.2
Delay disc. indifference point, 2s delay	1.3	1.5	3.6	-1.9	-0.9	0.9	-0.9
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	-0.7	-0.2	0.4	-0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.7	0.4	-0.2	0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.5	-0.3	0.2	-0.2
Indifference point function ln k	0.4	0.8	0.9	-0.9	-1.0	0.9	-0.9
Indifference point function log k	0.4	0.8	0.9	-0.9	-1.0	0.9	-0.9
Patch foraging total patch changes 0 sec	1.4	2.7	3.7	1.2	1.9	-1.7	1.7
Patch foraging total patch changes 12 sec	1.2	1.5	2.2	1.0	1.5	-1.2	1.2
Patch foraging total patch changes 18 sec	3.9	6.0	6.5	2.6	2.5	-2.4	2.4
Patch foraging total patch changes 24 sec	1.0	1.7	3.8	2.0	1.1	-0.9	0.9
Patch foraging total patch changes 6 sec	1.5	2.3	2.8	1.3	1.7	-1.5	1.5
Patch foraging time to switch 0 sec	1.9	3.9	4.8	1.8	1.8	-2.2	2.2
Patch foraging water rate 0 sec	0.1	0.1	0.2	-0.5	0.3	-0.3	0.3
Patch foraging water rate 12 sec	0.2	0.5	1.4	1.2	0.5	-0.4	0.4
Patch foraging water rate 18 sec	0.3	0.4	0.6	0.5	0.8	-0.7	0.7
Patch foraging water rate 24 sec	0.3	0.5	0.8	0.9	0.7	-0.5	0.5
Patch foraging water rate 6 sec	0.5	0.7	0.7	0.9	0.8	-0.8	0.8
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.5	0.7	1.2	-0.7	0.7
Distance traveled before self-admin	0.4	0.5	0.8	0.2	0.7	-0.9	0.9
Distance traveled after self-admin	0.6	0.7	1.3	0.0	1.2	-0.8	0.8
Extensor digitorum longus weight	0.1	0.4	1.2	-1.1	-0.6	0.3	-0.3
Bone: elastic displacement	0.0	0.0	0.1	0.3	-0.2	0.1	-0.1
Bone: elastic work	0.1	0.1	0.1	0.0	0.2	-0.3	0.3
Bone: endosteal estimation	1.1	2.5	9.7	-3.1	-0.4	0.2	-0.2
Bone: endosteal perimeter	1.2	2.6	7.8	-2.8	-1.1	0.8	-0.8
Epididymis fat weight	10.3	35.1	39.3	6.3	5.7	-5.9	5.9
Delta time in closed arm before/after self-admin	0.3	0.3	0.4	-0.3	0.4	-0.6	0.6
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.5	0.1	0.1	-0.1
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	0.2	-0.7	0.4	-0.4
Delay discount exponential model param	0.2	0.2	0.6	0.8	0.2	-0.3	0.3
Extinction: sum of active levers before priming	0.7	0.7	1.2	-1.1	-0.8	0.7	-0.7
Active lever presses in extinction session 6	0.0	0.0	0.0	0.2	-0.2	-0.0	0.0
Bone: final force	2.5	4.0	5.4	1.1	2.3	-2.2	2.2
Bone: final moment	1.7	2.7	3.6	0.9	1.9	-1.8	1.8
Food consumed during 24 hour testing period	0.4	0.6	0.8	-0.4	0.7	-0.9	0.9
Glucose	6.9	10.8	17.4	-4.2	-3.1	2.8	-2.8
Heart weight	0.3	0.5	2.1	-1.5	0.0	0.1	-0.1
Delay discount hyperbolic model param	0.2	0.3	0.7	0.9	0.2	-0.4	0.4
Intermittent access intake day 1-15 change	0.0	0.0	0.0	0.1	0.2	-0.0	0.0
Intermittent access intake escalation	0.2	0.3	0.6	0.8	0.6	-0.4	0.4
Intermittent access intake escalation 2	0.2	0.2	0.3	-0.4	-0.3	0.5	-0.5
Intermitt. access day 1 inactive lever presses	0.1	0.5	1.5	-1.2	-0.4	0.4	-0.4
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	-0.4	0.3	-0.3	0.3
Intermitt. access escalation Index	0.2	0.2	0.4	0.1	-0.6	0.5	-0.5
Intermittent access day 1 total infusions	1.1	1.8	2.9	-0.7	-1.7	1.4	-1.4
Intermittent access day 15 total infusions	0.1	0.2	0.2	0.3	-0.5	0.5	-0.5
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.4	-0.2	-0.6	0.6	-0.6
Intermittent access total infusions	0.4	0.5	0.7	-0.2	-0.9	0.8	-0.8
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.3	-0.2	-0.0	0.0
Intermittent access day 15 total locomotion	0.3	0.5	0.7	0.1	0.8	-0.8	0.8
Intermittent access total locomotion	0.1	0.1	0.2	0.4	0.3	-0.4	0.4
Intermittent access standard deviation	1.0	2.0	2.7	0.8	1.6	-1.6	1.6
Left kidney weight	2.0	9.1	11.9	1.3	3.5	-3.4	3.4
Right kidney weight	2.2	9.8	12.7	1.2	3.5	-3.6	3.6
Cocaine induced anxiety	0.0	0.0	0.0	-0.1	0.2	-0.2	0.2
Post-drug Anxiety	0.1	0.2	0.2	0.1	0.5	-0.4	0.4
Baseline Anxiety	0.0	0.0	0.0	-0.2	0.2	-0.2	0.2
Tail length	0.6	2.2	8.7	-3.0	-0.1	0.3	-0.3
Length with tail	0.6	2.5	8.3	-2.9	0.7	-0.8	0.8
Length without tail	1.5	4.9	7.0	-1.0	2.1	-2.6	2.6
Times rat made contact with spout	0.4	0.5	1.9	1.4	0.2	0.1	-0.1
Lifetime Intake	0.3	0.4	0.6	-0.3	-0.8	0.7	-0.7
Liver weight, left	0.5	0.8	3.2	-1.8	0.1	-0.1	0.1
Liver weight, right	1.2	2.0	7.1	-2.7	-0.7	0.5	-0.5
Locomotor activity	0.1	0.2	0.5	-0.7	0.3	0.2	-0.2
Locomotor testing distance	0.0	0.1	0.3	-0.5	0.3	-0.1	0.1
Locomotor testing rearing	0.2	0.4	0.5	-0.5	0.7	-0.6	0.6
Locomotion in novel chamber	0.2	0.2	0.4	0.6	0.5	-0.3	0.3
Locomotion in novel chamber post-restriction	0.9	1.4	1.8	0.6	1.3	-1.3	1.3
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	0.2	-0.4	0.1	-0.1
Change in fecal boli incidents, locomotor task	0.5	0.5	1.8	-1.4	0.1	-0.1	0.1
Time >=10cm from walls, locomotor time 1	1.7	1.8	2.6	-0.5	1.4	-1.6	1.6
Bouts of movement, locomotor time 1	0.2	0.2	0.3	0.3	-0.3	0.6	-0.6
Total resting periods, locomotor time 1	0.3	0.3	0.5	0.0	-0.4	0.7	-0.7
Rest time, locomotor task time 1	0.6	0.7	0.9	-0.7	-0.8	0.9	-0.9
Distance moved, locomotor task time 1	0.4	0.6	0.9	0.2	0.9	-0.9	0.9
Vertical activity count, locomotor time 1	1.0	2.3	2.8	0.9	1.7	-1.7	1.7
Time >=10cm from walls, locomotor time 2	0.5	0.8	2.1	-1.4	0.5	-0.7	0.7
Bouts of movement, locomotor time 2	0.2	0.3	0.5	-0.2	-0.2	0.7	-0.7
Total resting periods, locomotor time 2	0.6	1.1	1.6	-0.7	-0.8	1.3	-1.3
Rest time, locomotor task time 2	0.4	0.5	0.8	-0.9	-0.6	0.7	-0.7
Distance moved, locomotor task time 2	1.1	1.3	1.9	0.5	1.1	-1.4	1.4
Vertical activity count, locomotor time 2	0.7	0.9	1.4	0.2	0.9	-1.2	1.2
Light reinforcement 1	1.3	3.1	3.9	1.1	1.9	-2.0	2.0
Light reinforcement 2	0.6	0.9	1.3	0.0	1.0	-1.1	1.1
Bone: marrow area	1.1	2.3	9.2	-3.0	-0.2	0.0	-0.0
Bone: maximum diameter	1.4	2.6	5.1	-2.3	-1.4	1.3	-1.3
Bone: maximum force	1.1	1.9	2.5	0.5	1.5	-1.6	1.6
Bone: maximum moment	0.6	1.0	1.4	0.2	1.0	-1.2	1.2
Mean time between licks in bursts	1.9	4.6	5.1	-2.2	-2.1	2.1	-2.1
Mean num. licks in bursts	1.2	1.9	4.1	2.0	1.2	-1.0	1.0
Cd content in liver	0.7	0.8	1.1	0.7	0.5	-1.1	1.1
Co content in liver	2.1	2.4	3.0	1.0	1.7	-1.7	1.7
Cu content in liver	0.6	0.8	2.9	1.7	0.4	0.0	-0.0
Fe content in liver	1.3	1.6	1.6	1.2	1.2	-1.3	1.3
K content in liver	0.3	0.3	0.5	0.2	-0.6	0.7	-0.7
Mg content in liver	2.0	2.0	2.3	-1.2	-1.4	1.5	-1.5
Mn content in liver	1.9	2.0	4.3	-2.1	-1.3	1.0	-1.0
Na content in liver	0.2	0.2	0.8	0.9	0.3	0.0	-0.0
Rb content in liver	0.0	0.0	0.1	-0.1	-0.3	-0.0	0.0
Se content in liver	4.9	5.8	6.2	-2.5	-2.2	2.5	-2.5
Sr content in liver	0.3	0.3	0.8	-0.9	-0.3	-0.3	0.3
Zn content in liver	0.3	0.3	0.7	-0.8	-0.5	0.5	-0.5
Bone: minimum diameter	0.8	1.4	4.8	-2.2	-0.7	0.4	-0.4
Time in familiar zone, hab. session 1	0.8	0.8	3.0	1.7	-0.1	0.2	-0.2
Time in novel zone, hab. session 1	0.6	0.6	2.2	-1.5	0.3	-0.2	0.2
Total zone transitions, hab. session 1	0.1	0.2	0.2	0.2	-0.5	0.5	-0.5
Total locomotion distance, hab. session 1	0.1	0.2	0.2	0.4	-0.4	0.4	-0.4
Locomotion velocity, hab. session 1	0.1	0.2	0.2	0.2	-0.4	0.5	-0.5
Time in familiar zone, hab. session 2	1.5	1.6	3.0	1.7	1.2	-1.0	1.0
Time in novel zone, hab. session 2	0.6	0.6	1.4	-1.2	-0.6	0.5	-0.5
Total zone transitions, hab. session 2	0.5	0.7	0.9	1.0	0.7	-0.8	0.8
Total locomotion distance, hab. session 2	0.3	0.4	1.3	1.1	0.2	-0.3	0.3
Locomotion velocity, hab. session 2	0.1	0.2	0.7	0.8	-0.2	0.1	-0.1
Novel to familiar place preference ratio	0.3	0.4	0.4	-0.5	-0.7	0.6	-0.6
Novelty place preference	0.5	0.5	0.5	-0.7	-0.7	0.7	-0.7
Time in novel zone, NPP test	0.5	0.5	0.6	-0.7	-0.7	0.7	-0.7
Total zone transitions, NPP test	0.3	0.5	0.9	0.2	-1.0	0.7	-0.7
Total locomotion distance, NPP test	0.1	0.2	0.3	0.5	-0.5	0.2	-0.2
Locomotion velocity, NPP test	0.2	0.3	0.5	0.7	-0.6	0.3	-0.3
Intraocular pressure	0.4	0.6	1.3	1.1	0.4	-0.7	0.7
Delta distance traveled before/after self-admin	0.1	0.1	0.2	-0.5	0.2	0.3	-0.3
Delta ambulatory time before/after self-admin	0.1	0.2	0.4	-0.6	0.2	0.4	-0.4
Parametrial fat weight	4.1	9.7	11.7	2.4	3.1	-3.4	3.4
Pavlov. Cond. lever latency	9.0	11.3	12.7	2.7	3.6	-3.6	3.6
Pavlov. Cond. magazine entry latency	4.9	6.3	7.6	-1.9	-2.5	2.8	-2.8
Pavlov. Cond. change in total contacts	3.2	3.4	4.0	-1.6	-1.8	2.0	-2.0
Pavlov. Cond. index score	7.4	9.3	10.3	-2.5	-3.2	3.2	-3.2
Pavlov. Cond. latency score	7.9	9.9	11.2	-2.6	-3.3	3.3	-3.3
Pavlov. Cond. lever contacts	6.8	8.1	9.2	-2.5	-3.0	2.9	-2.9
Pavlov. Cond. magazine entry number	3.4	4.3	5.2	1.6	2.1	-2.3	2.3
Pavlov. Cond. intertrial magazine entries	1.5	1.8	2.8	1.7	1.2	-1.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	7.2	8.9	10.0	-2.4	-3.1	3.2	-3.2
Pavlov. Cond. response bias	5.1	6.3	7.1	-2.1	-2.6	2.7	-2.7
Pavlov. Cond. lever latency	0.2	0.3	0.4	-0.7	0.2	-0.5	0.5
Pavlov. Cond. magazine entry latency	0.8	0.9	1.2	-1.0	-1.1	0.9	-0.9
Pavlov. Cond. change in total contacts	0.2	0.3	0.4	0.0	-0.4	0.7	-0.7
Pavlov. Cond. index score	0.4	0.6	0.8	-0.3	-0.8	0.9	-0.9
Pavlov. Cond. latency score	0.3	0.3	0.5	-0.2	-0.6	0.7	-0.7
Pavlov. Cond. lever contacts	0.1	0.2	0.4	0.6	-0.1	0.4	-0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.3	0.4	-0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.6	0.9	1.2	-0.7	-0.8	1.1	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	-0.2	-0.7	0.7	-0.7
Pavlov. Cond. response bias	0.4	0.5	0.8	-0.0	-0.8	0.9	-0.9
Time in closed arm before self-admin	0.2	0.2	0.5	-0.7	-0.4	0.4	-0.4
Time in closed arm after self-admin	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.1
Time in open arm before self-admin	1.5	1.7	2.1	-0.8	-1.3	1.5	-1.5
Time in open arm after self-admin	0.5	0.6	0.9	-0.3	-0.7	0.9	-0.9
Bone: periosteal estimation	0.4	0.9	3.6	-1.9	0.1	-0.2	0.2
Bone: periosteal perimeter	0.6	1.0	3.1	-1.8	-0.6	0.6	-0.6
Bone: post-yield work	0.6	0.9	2.7	-1.6	-0.7	0.5	-0.5
Progressive ratio test 1 active lever presses	0.4	0.4	0.6	-0.7	-0.8	0.6	-0.6
Progressive ratio test 1 breakpoint	0.4	0.5	0.6	-0.8	-0.8	0.6	-0.6
Progressive ratio test 1 inactive lever presses	0.6	0.8	1.0	1.0	0.7	-0.9	0.9
Progressive ratio test 2 active lever presses	0.1	0.2	0.2	0.2	-0.5	0.4	-0.4
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	0.3	-0.5	0.4	-0.4
Progressive ratio test 2 inactive lever presses	1.0	1.6	1.9	-1.3	-1.4	1.2	-1.2
Incentive Sensitization - Responses	0.2	0.3	0.4	0.2	-0.5	0.6	-0.6
Incentive Sensitization - Breakpoint	0.1	0.2	0.2	0.4	-0.4	0.5	-0.5
Sum of active levers in priming session hrs 5-6	1.4	1.3	1.5	-1.0	-1.1	1.2	-1.2
Progressive ratio	4.2	6.5	9.0	1.6	3.0	-2.7	2.7
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.2	-0.0	0.2	-0.2
Seeking ratio, punishment vs. effort	4.0	5.7	7.0	-1.6	-2.6	2.6	-2.6
Retroperitoneal fat weight	0.4	1.7	2.2	1.1	1.1	-1.5	1.5
Reaction time number correct	1.4	2.7	3.0	1.5	1.6	-1.7	1.7
Reaction time mean minus median	1.4	3.4	4.1	-1.5	-2.0	1.9	-1.9
Reaction time mean minus median AUC	1.8	4.7	6.2	-1.8	-2.5	2.1	-2.1
Reaction time num false alarms	0.3	0.4	0.5	-0.7	-0.4	0.6	-0.6
Reaction time num false alarms AUC	0.3	0.4	0.7	-0.8	-0.4	0.7	-0.7
Reaction time trials correct on left	1.4	2.7	3.0	1.5	1.6	-1.7	1.7
Reaction time trials on left	1.3	2.5	2.7	1.4	1.5	-1.7	1.7
Reaction time mean	1.9	3.1	3.8	-1.9	-2.0	1.5	-1.5
Reaction time mean AUC	1.9	3.0	3.8	-1.9	-1.9	1.5	-1.5
Median of all reaction times	1.2	1.7	2.6	-1.6	-1.5	1.0	-1.0
Reaction time omissions	0.9	1.4	1.7	-1.2	-1.3	1.1	-1.1
Reaction time false alarm rate	2.0	2.8	3.1	-1.8	-1.4	1.7	-1.7
Reaction time premature initiation rate	0.1	0.1	0.2	-0.0	0.3	-0.4	0.4
Reaction time premature initiations	1.0	1.7	2.2	0.8	1.4	-1.5	1.5
Std. dev. reaction times	3.0	5.5	5.8	-2.3	-2.4	2.3	-2.3
Reaction time trials completed	1.3	2.5	2.7	1.4	1.5	-1.7	1.7
Reaction time trials AUC	1.4	2.7	3.0	1.5	1.6	-1.7	1.7
Run reversals in cocaine runway, females	0.4	0.4	0.6	0.8	0.5	-0.7	0.7
Run reversals in cocaine runway, males	1.1	1.1	1.2	-0.8	-1.1	1.1	-1.1
Latency to leave start box in cocaine runway	0.6	0.7	1.0	-1.0	-0.9	0.7	-0.7
Latency to leave start box in cocaine runway, F	0.6	0.6	0.9	-0.8	-1.0	0.7	-0.7
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.3	0.0	-0.2	0.2
Std. dev. time between licks in bursts	3.2	4.4	7.2	-2.7	-1.8	1.9	-1.9
Total sessions with >9 infusions	0.4	0.5	0.6	-0.5	-0.7	0.8	-0.8
Short access day 1 total inactive lever presses	1.7	2.3	3.1	-1.8	-1.5	1.3	-1.3
Short access day 10 total inactive lever presses	0.0	0.1	0.3	0.5	0.3	-0.2	0.2
Short access day 1 total infusions	1.2	1.7	1.9	-1.2	-1.4	1.3	-1.3
Short access day 10 total infusions	0.2	0.2	0.4	0.0	-0.6	0.5	-0.5
Short access total infusions	0.7	0.8	1.2	-0.7	-1.1	0.9	-0.9
Short access day 1 locomotion	0.4	0.5	0.7	-0.3	-0.8	0.8	-0.8
Short access day 10 total locomotion	0.3	0.5	1.6	-1.3	0.5	-0.2	0.2
Short access total locomotion	0.3	0.4	1.2	-1.1	-0.3	0.3	-0.3
One hour access (0.3 mA shock)	0.4	0.4	0.5	0.5	-0.7	0.7	-0.7
Compulsive drug intake	0.1	0.1	0.1	-0.4	-0.2	0.2	-0.2
One hour access (shock baseline)	0.1	0.1	0.4	0.6	-0.3	0.2	-0.2
Social response proportion	0.3	0.3	1.3	-1.1	0.0	-0.1	0.1
Social responses	0.1	0.1	0.4	-0.7	0.3	-0.2	0.2
Social time	0.6	0.9	1.3	-1.1	-0.8	0.9	-0.9
Soleus weight	1.5	4.5	14.1	-3.8	-1.5	0.9	-0.9
Bone: stiffness	1.4	2.3	2.6	1.2	1.6	-1.6	1.6
Tibialis anterior weight	0.5	1.6	2.5	1.6	1.3	-1.1	1.1
Time to tail flick, vehicle, before self-admin	1.4	1.4	2.1	1.5	1.1	-1.1	1.1
Time to tail flick, vehicle, after self-admin	0.7	0.9	1.0	-0.9	-0.9	1.0	-1.0
Time to tail flick, test, before self-admin	0.3	0.3	1.1	1.0	0.5	-0.1	0.1
Time to tail flick, test, after self-admin	1.2	1.3	1.8	0.3	-1.2	1.4	-1.4
Delta time to tail flick, vehicle, before/after SA	1.9	1.9	2.5	-0.8	-1.6	1.4	-1.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.3	-0.3	0.1	-0.1
Tibia length	0.3	0.9	3.1	-1.8	0.5	-0.4	0.4
Ambulatory time before self-admin	0.0	0.1	0.1	0.2	0.2	-0.3	0.3
Ambulatory time after self-admin	0.2	0.2	0.5	-0.2	0.7	-0.3	0.3
Bone: tissue strength	0.1	0.1	0.1	-0.2	0.1	-0.3	0.3
Total heroin consumption	0.0	0.0	0.0	-0.0	0.0	0.2	-0.2
Bone: trabecular number	0.5	0.9	3.3	1.8	-0.2	0.3	-0.3
Bone: trabecular spacing	0.8	1.1	2.6	-1.6	0.4	-0.9	0.9
Bone: trabecular thickness	0.5	0.7	2.7	1.6	0.2	-0.1	0.1
Bone: trabecular tissue density	0.5	0.8	0.8	-0.9	-0.8	0.9	-0.9
Water consumed over 24 hours	0.1	0.2	0.5	-0.7	-0.3	0.3	-0.3
Number of responses in last shaping day	2.8	3.1	6.3	-2.5	-1.3	1.4	-1.4