Hub : Genes

RT1-Ba

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression RT1-Ba 0.19 0.09 3.1e-06 0.11 0.11 0.08 0.11 2.5e-05 3.5e-05 2.4e-04 2.2e-05
2 PL gene expression RT1-Ba 0.1 0.05 4.5e-07 0.04 0.05 0.05 0.04 9.9e-05 1.8e-06 9.3e-06 2.9e-05
3 pVTA gene expression RT1-Ba 0.08 0.04 1.4e-05 0.06 0.05 0.03 0.05 2.4e-05 1.2e-04 1.6e-03 7.7e-05
4 IL gene expression RT1-Ba 0.24 0.13 6.7e-03 0.07 0.11 0.07 0.07 9.0e-03 1.5e-03 8.0e-03 9.4e-03
5 Adipose mRNA stability RT1-Ba 0.72 0.07 0.0e+00 0.52 0.59 0.67 0.64 1.5e-66 2.9e-81 4.9e-100 8.6e-94
6 Brain gene expression RT1-Ba 0.28 0.12 0.0e+00 0.08 0.19 0.17 0.18 8.2e-08 3.8e-17 4.5e-16 2.2e-16
7 LHb gene expression RT1-Ba 0.37 0.15 1.2e-04 0.06 0.12 0.16 0.22 1.3e-02 8.8e-04 1.7e-04 5.5e-06
8 Liver mRNA stability RT1-Ba 0.69 0.05 0.0e+00 0.52 0.68 0.76 0.76 4.6e-68 1.2e-103 5.7e-130 6.4e-127
9 Adipose gene expression RT1-Ba 0.58 0.1 0.0e+00 0.51 0.56 0.57 0.57 3.5e-66 3.1e-74 2.0e-77 5.2e-77
10 Liver gene expression RT1-Ba 0.12 0.05 3.4e-12 0.11 0.1 0.11 0.12 2.1e-12 6.0e-11 1.6e-12 9.4e-13
11 BLA gene expression RT1-Ba 0.1 0.06 2.6e-03 0.03 0.04 0.01 0.03 1.7e-02 5.0e-03 6.1e-02 1.1e-02
12 NAcc gene expression RT1-Ba 0.05 0.03 2.8e-07 0.03 0.05 0.05 0.05 6.4e-05 1.5e-07 1.0e-07 8.4e-08
13 pVTA intron excision ratio chr20_4580835_4581082 0.04 0.02 6.8e-03 0 0.01 0.02 0 1.5e-01 2.1e-02 1.6e-02 1.5e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.20.41.70.2-0.91.3-0.80.2-0.1-0.00.30.00.5-1.10.50.4
Area under the delay curve0.10.10.4-0.40.0-0.70.3-0.0-0.4-0.2-0.1-0.40.1-0.0-0.20.1
BMI with tail1.44.910.5-2.3-1.4-2.5-2.9-2.9-1.8-2.5-2.5-1.0-3.2-0.4-2.00.9
BMI without tail1.64.810.4-2.4-1.4-3.2-1.8-2.6-2.2-2.3-2.5-1.9-2.4-0.8-2.81.3
Body weight1.14.813.0-2.1-0.2-3.6-1.8-2.8-1.4-2.0-2.5-0.5-3.61.2-2.61.1
Weight adjusted by age0.20.31.3-0.20.3-0.90.0-0.50.0-0.1-0.40.1-1.11.1-0.4-0.2
Bone surface0.30.62.50.60.80.40.50.50.80.60.80.70.30.61.6-1.1
Bone volume0.00.10.50.1-0.20.3-0.3-0.0-0.0-0.10.20.10.0-0.30.7-0.4
Breakpoint value in progressive ratio session0.30.30.60.60.60.70.60.60.60.70.70.50.40.20.8-0.3
Number of licking bursts1.42.33.71.71.91.21.81.51.81.31.61.61.11.51.3-1.3
Context. condit. distance diff. score6.37.610.73.32.73.22.33.13.13.13.03.32.32.12.4-1.1
Locomotion velocity, session 11.82.04.11.70.91.51.71.71.11.51.50.52.00.31.6-1.0
Locomotion distance, session 10.20.20.90.3-0.31.0-0.20.40.20.10.20.00.7-0.60.00.7
Locomotion velocity, session 20.60.71.31.00.80.80.91.00.80.90.90.70.90.41.1-0.6
Locomotion distance, session 20.30.41.20.80.31.1-0.10.70.70.40.70.90.40.40.7-0.1
Locomotion velocity, session 30.60.71.5-0.9-0.9-0.7-0.4-0.6-1.1-1.0-0.9-1.1-0.0-1.2-1.2-0.0
Locomotion distance, session 30.30.31.40.5-0.21.20.20.70.20.20.40.21.0-0.7-0.00.2
Stereotopy head waving bouts, day 30.40.51.60.21.1-0.70.90.20.70.50.20.5-0.21.30.5-1.1
Stereotopy head waving duration, day 30.20.31.6-0.00.6-0.80.80.10.10.30.1-0.20.00.70.2-1.3
Locomotion velocity, session 71.11.25.01.30.22.2-0.11.21.00.81.21.51.00.20.90.0
Locomotion distance, session 71.31.76.71.6-0.12.60.41.60.91.01.41.11.9-0.51.00.1
Stereotopy head waving bouts, day 70.40.41.4-0.2-0.1-0.50.90.2-0.60.1-0.0-1.21.0-0.8-0.4-0.7
Stereotopy head waving duration, day 70.30.31.3-0.6-0.2-0.90.4-0.3-0.7-0.2-0.4-1.10.3-0.5-0.6-0.5
Locomotion velocity, session 85.26.38.92.83.02.02.82.62.82.82.52.51.72.52.6-1.8
Locomotion distance, session 84.56.511.63.12.53.31.72.73.12.62.73.41.72.12.3-0.7
Degree of sensitization distance1.11.11.81.21.20.81.00.91.31.01.01.30.41.21.3-0.5
Degree of sensitization stereotypy0.40.41.90.1-0.20.10.80.5-0.50.20.2-1.11.4-1.1-0.1-0.4
Conditioned locomotion0.40.51.4-0.10.8-0.5-0.1-0.40.5-0.10.10.9-1.01.20.7-0.9
Cocaine response after cond. corrected0.50.62.70.60.70.7-0.50.11.00.20.31.6-0.81.20.3-0.3
Cocaine response after cond. not corrected0.60.72.50.71.30.10.40.21.10.60.41.3-0.61.60.4-0.7
Cocaine response before conditioning0.40.52.4-0.40.6-1.61.3-0.3-0.30.1-0.4-1.0-0.00.3-0.2-0.6
Saline control response4.86.49.7-3.0-2.6-3.1-2.1-2.7-3.1-2.5-2.6-3.1-1.8-2.2-2.21.0
Bone: connectivity density0.20.41.60.4-0.21.3-0.60.30.50.50.60.70.2-0.11.10.1
Bone: cortical apparent density2.12.94.8-2.0-1.7-1.8-2.1-2.2-1.9-2.1-1.8-1.5-1.8-1.2-0.60.2
Bone: cortical area0.00.00.20.10.4-0.40.2-0.1-0.1-0.0-0.1-0.1-0.10.3-0.1-0.1
Bone: cortical porosity0.80.83.70.0-0.1-0.01.50.9-0.50.50.4-1.41.9-1.1-0.2-0.5
Bone: cortical porosity1.01.04.30.60.50.32.01.30.10.90.8-0.82.1-0.40.3-0.7
Bone: cortical thickness1.62.74.1-1.7-1.7-1.4-1.7-1.8-2.0-1.9-1.8-1.9-1.0-1.7-1.51.1
Bone: cortical thickness3.44.05.8-2.4-2.1-2.3-2.3-2.4-2.3-2.4-2.2-1.9-1.8-1.7-1.00.3
Bone: cortical tissue density1.92.64.3-1.9-1.6-1.7-1.9-2.1-1.8-2.0-1.7-1.4-1.7-1.1-0.40.0
Condit. Reinf. active minus inactive responses0.40.41.70.6-0.30.90.70.70.00.30.5-0.61.3-0.70.50.4
Condit. Reinf. active-inactive response ratio0.70.71.8-0.8-1.0-0.7-0.4-0.7-1.0-0.7-0.8-1.3-0.1-1.0-0.81.1
Condit. Reinf. active responses0.20.31.00.5-0.61.00.10.4-0.00.00.1-0.30.7-0.70.21.0
Condit. Reinf. inactive responses0.30.41.30.2-0.91.2-0.70.0-0.2-0.4-0.1-0.00.3-0.9-0.11.2
Incentive salience index mean1.72.13.81.81.11.91.31.71.41.51.71.11.60.71.6-0.3
Condit. Reinf. lever presses3.95.58.62.72.32.91.62.42.72.42.62.91.52.02.4-0.8
Condit. Reinf. active minus inactive responses0.10.10.4-0.10.1-0.60.5-0.1-0.30.1-0.3-0.4-0.10.0-0.40.3
Condit. Reinf. active-inactive response ratio0.20.31.10.50.8-0.31.10.30.40.70.20.10.10.8-0.0-0.0
Condit. Reinf. active responses0.10.10.3-0.2-0.2-0.30.2-0.1-0.3-0.1-0.2-0.60.1-0.4-0.40.3
Condit. Reinf. inactive responses0.50.71.1-1.0-1.0-0.6-0.9-0.8-0.9-1.1-0.7-0.9-0.5-1.0-0.60.4
Condit. Reinf. lever presses0.30.41.70.5-0.30.90.60.6-0.20.20.3-0.51.3-0.9-0.20.4
Condit. Reinf. lever reinforcers received0.10.10.30.1-0.1-0.10.50.1-0.20.1-0.0-0.50.4-0.4-0.20.4
Conditioned reinforcement - actives0.10.21.1-0.2-0.60.1-0.5-0.3-0.4-0.5-0.4-0.2-0.3-0.5-0.01.0
Conditioned reinforcement - inactives0.10.10.40.1-0.60.0-0.3-0.1-0.3-0.3-0.2-0.4-0.1-0.4-0.20.3
Conditioned locomotion0.10.10.20.3-0.00.40.20.40.20.30.40.40.20.20.5-0.1
Patch foraging indifference point 0 sec2.03.85.7-2.4-2.0-2.2-1.7-2.1-2.2-2.2-2.0-2.1-1.7-1.4-1.61.2
Patch foraging indifference point AUC0.10.10.5-0.10.2-0.50.70.2-0.10.30.0-0.50.4-0.20.5-0.2
Delay disc. indifference point, 0s delay0.40.51.10.70.90.60.60.60.80.50.70.80.11.00.8-0.4
Delay disc. indifference point, 16s delay0.60.71.5-1.1-1.0-0.9-0.6-0.6-1.2-0.9-0.7-1.1-0.0-1.0-0.70.0
Delay disc. indifference point, 2s delay0.50.51.60.50.9-0.11.30.80.50.90.60.30.60.90.60.1
Delay disc. indifference point, 24s delay0.40.41.5-0.6-0.7-0.80.2-0.3-0.9-0.6-0.4-1.20.3-0.6-0.4-0.3
Delay disc. indifference point, 4s delay0.20.21.2-0.60.2-1.10.3-0.4-0.4-0.4-0.3-0.4-0.40.2-0.20.0
Delay disc. indifference point, 8s delay0.00.00.2-0.2-0.1-0.30.1-0.0-0.4-0.1-0.1-0.40.2-0.1-0.10.1
Indifference point function ln k0.61.02.30.81.10.81.21.00.90.91.10.81.00.61.2-1.5
Indifference point function log k0.61.02.30.81.10.81.21.00.90.91.10.81.00.61.2-1.5
Patch foraging total patch changes 0 sec2.24.16.0-2.5-2.1-2.3-1.8-2.2-2.3-2.4-2.1-2.3-1.7-1.5-1.61.0
Patch foraging total patch changes 12 sec1.72.23.8-2.0-1.5-1.9-1.1-1.6-1.7-1.6-1.6-1.8-1.3-1.2-0.50.3
Patch foraging total patch changes 18 sec3.45.27.4-2.7-2.5-2.2-2.7-2.5-2.5-2.7-2.3-2.0-2.1-1.9-1.71.3
Patch foraging total patch changes 24 sec1.52.65.2-1.6-2.3-0.9-1.9-1.4-2.0-1.5-1.5-1.7-0.7-2.0-1.41.5
Patch foraging total patch changes 6 sec2.43.75.4-2.3-2.1-2.1-1.8-2.0-2.3-1.9-2.0-2.2-1.5-1.6-1.61.4
Patch foraging time to switch 0 sec0.71.54.5-1.0-0.8-0.6-2.1-1.5-0.7-1.2-1.20.2-2.00.1-1.40.9
Patch foraging water rate 0 sec0.00.10.3-0.3-0.1-0.6-0.1-0.3-0.2-0.3-0.4-0.2-0.40.3-0.1-0.4
Patch foraging water rate 12 sec0.20.41.1-0.6-1.0-0.2-0.8-0.5-0.9-0.8-0.5-0.7-0.0-1.1-0.40.4
Patch foraging water rate 18 sec0.30.50.8-0.7-0.7-0.6-0.7-0.8-0.8-0.8-0.8-0.6-0.7-0.4-0.90.3
Patch foraging water rate 24 sec0.40.51.2-0.7-0.7-0.5-0.7-0.8-0.7-1.1-0.7-0.5-0.5-0.7-0.70.8
Patch foraging water rate 6 sec0.30.41.0-0.7-0.6-0.6-0.8-0.7-0.6-0.7-0.8-0.4-0.7-0.4-1.00.4
Seeking ratio, delayed vs. immediate footshock1.01.23.0-1.2-0.5-1.7-0.1-1.1-1.1-0.6-1.2-1.4-0.8-0.9-1.11.3
Distance traveled before self-admin0.30.41.30.30.7-0.1-0.3-0.10.70.20.31.1-1.11.10.20.1
Distance traveled after self-admin0.30.31.4-0.50.4-1.2-0.0-0.7-0.2-0.3-0.5-0.1-0.90.5-0.5-0.2
Extensor digitorum longus weight0.20.92.40.91.30.60.80.91.21.01.01.60.11.40.4-0.1
Bone: elastic displacement0.50.61.7-0.4-1.2-0.1-0.3-0.2-1.1-0.3-0.6-1.20.4-1.3-0.80.6
Bone: elastic work0.10.10.4-0.3-0.4-0.4-0.3-0.3-0.7-0.0-0.3-0.6-0.2-0.4-0.2-0.2
Bone: endosteal estimation1.53.39.61.42.8-0.42.11.02.01.81.32.0-0.43.11.1-1.8
Bone: endosteal perimeter2.24.69.52.33.11.02.31.82.72.21.92.50.43.11.2-1.4
Epididymis fat weight7.726.243.7-5.6-5.3-4.3-6.6-5.8-5.2-5.9-5.5-3.7-5.1-3.7-5.03.7
Delta time in closed arm before/after self-admin0.20.20.80.20.40.1-0.2-0.20.40.2-0.10.4-0.60.90.60.3
Delta time in open arm before/after self-admin0.20.20.7-0.4-0.7-0.3-0.3-0.4-0.7-0.4-0.2-0.60.1-0.8-0.3-0.2
Diff in mean of infusions in LGA sessions0.60.82.11.00.71.50.20.91.10.80.91.30.60.50.8-0.1
Delay discount exponential model param0.10.10.50.4-0.00.7-0.40.00.50.20.10.5-0.20.10.2-0.1
Extinction: sum of active levers before priming1.11.22.11.11.21.01.01.11.31.11.31.30.51.11.5-0.6
Active lever presses in extinction session 60.20.20.5-0.1-0.70.5-0.6-0.1-0.4-0.2-0.0-0.40.2-0.5-0.20.5
Bone: final force1.62.66.1-1.6-0.9-2.1-1.8-2.1-1.3-1.6-1.8-0.7-2.5-0.0-1.60.9
Bone: final moment1.21.94.2-1.4-0.9-1.8-1.6-1.8-1.2-1.4-1.6-0.7-2.0-0.1-1.50.9
Food consumed during 24 hour testing period0.40.62.60.21.0-0.3-0.2-0.20.80.10.21.3-1.11.60.1-0.6
Glucose5.89.013.33.63.52.63.53.33.63.43.03.22.13.31.4-1.0
Heart weight0.30.41.5-0.30.1-1.20.6-0.5-0.5-0.1-0.7-0.9-0.10.3-1.00.5
Delay discount hyperbolic model param0.10.10.50.4-0.10.7-0.5-0.10.40.10.00.5-0.30.10.2-0.3
Intermittent access intake day 1-15 change0.10.10.4-0.6-0.1-0.70.1-0.2-0.3-0.5-0.4-0.6-0.0-0.3-0.2-0.1
Intermittent access intake escalation0.51.12.5-1.3-1.1-1.2-0.5-0.8-1.3-1.2-1.1-1.6-0.3-1.3-0.90.3
Intermittent access intake escalation 20.10.10.70.00.2-0.00.60.30.0-0.10.1-0.30.5-0.10.4-0.9
Intermitt. access day 1 inactive lever presses0.52.14.31.82.11.31.21.12.00.91.21.80.02.11.1-0.4
Intermitt. access day 15 inactive lever presses0.00.10.3-0.00.2-0.5-0.0-0.20.10.1-0.10.0-0.50.4-0.00.0
Intermitt. access escalation Index1.01.42.71.41.31.60.71.11.51.31.21.60.70.91.0-0.1
Intermittent access day 1 total infusions0.50.82.91.1-0.41.70.31.10.30.90.90.31.4-0.40.90.0
Intermittent access day 15 total infusions0.30.41.6-0.5-1.10.0-0.3-0.0-0.8-0.4-0.4-1.00.4-1.3-0.20.4
Intermittent access terminal intake (last 3 days)0.30.41.2-0.4-1.0-0.0-0.10.1-0.7-0.3-0.3-1.00.6-1.1-0.10.3
Intermittent access total infusions0.20.31.00.0-0.90.5-0.10.3-0.50.0-0.0-0.70.7-1.00.00.3
Intermittent access day 1 locomotion0.10.20.60.0-0.80.4-0.6-0.1-0.3-0.2-0.1-0.1-0.2-0.5-0.20.8
Intermittent access day 15 total locomotion0.40.61.3-0.8-0.6-1.1-0.7-0.9-0.7-0.8-1.0-0.6-1.1-0.2-0.80.6
Intermittent access total locomotion0.50.71.2-0.7-1.1-0.6-0.8-0.7-1.0-1.0-0.9-0.9-0.7-0.8-0.60.8
Intermittent access standard deviation1.22.43.8-1.8-1.4-1.9-1.4-1.7-1.6-1.9-1.7-1.6-1.8-0.8-1.30.9
Left kidney weight1.46.713.6-3.0-1.1-3.7-2.2-3.3-2.4-2.9-3.0-1.8-3.1-0.2-2.91.6
Right kidney weight1.46.212.4-2.9-0.8-3.4-2.2-3.2-1.9-2.7-2.9-1.2-3.50.3-2.91.6
Cocaine induced anxiety0.30.51.30.31.00.10.40.31.00.30.51.1-0.41.00.7-0.2
Post-drug Anxiety0.20.20.6-0.40.6-0.60.1-0.20.4-0.1-0.10.4-0.80.60.00.8
Baseline Anxiety0.20.20.6-0.7-0.3-0.7-0.2-0.4-0.4-0.3-0.5-0.5-0.2-0.2-0.20.5
Tail length0.31.14.10.21.7-1.72.00.20.50.50.00.1-0.11.7-0.8-0.1
Length with tail0.31.46.50.01.9-2.01.3-0.30.60.4-0.20.7-1.22.5-0.7-0.1
Length without tail0.72.18.4-0.51.4-1.8-0.7-1.30.5-0.5-0.71.5-2.92.8-0.4-0.7
Times rat made contact with spout1.61.85.3-1.1-1.9-0.3-0.9-0.7-1.8-1.2-1.0-2.00.5-2.3-1.10.9
Lifetime Intake0.20.20.8-0.1-0.90.4-0.10.2-0.50.1-0.0-0.60.5-0.80.00.7
Liver weight, left1.01.66.01.12.1-0.11.20.41.70.80.61.8-0.62.50.0-0.4
Liver weight, right1.83.17.51.52.50.11.91.22.11.81.42.20.02.72.0-1.3
Locomotor activity0.20.41.3-0.30.8-1.11.00.00.10.1-0.2-0.3-0.10.4-1.00.6
Locomotor testing distance0.10.20.70.10.8-0.60.70.10.40.30.00.4-0.40.7-0.70.0
Locomotor testing rearing0.20.31.30.10.8-0.50.2-0.10.50.5-0.00.8-0.91.2-0.30.2
Locomotion in novel chamber0.10.10.3-0.5-0.3-0.2-0.4-0.4-0.5-0.4-0.2-0.2-0.4-0.3-0.4-0.1
Locomotion in novel chamber post-restriction0.71.12.6-1.2-0.7-1.6-1.1-1.3-1.0-1.0-1.2-0.6-1.2-0.2-1.00.6
Fecal boli incidents, locomotor time 10.10.20.60.4-0.10.8-0.30.40.30.20.70.60.10.10.60.1
Change in fecal boli incidents, locomotor task0.60.62.20.51.3-0.21.00.21.00.70.30.7-0.41.50.5-0.6
Time >=10cm from walls, locomotor time 11.01.04.3-0.21.4-1.0-0.1-0.70.9-0.1-0.01.3-1.72.10.5-0.1
Bouts of movement, locomotor time 10.10.10.30.20.30.50.40.30.20.00.3-0.10.5-0.3-0.10.1
Total resting periods, locomotor time 10.10.20.40.40.40.50.50.40.40.20.50.10.7-0.10.1-0.3
Rest time, locomotor task time 10.40.51.00.80.80.50.91.00.60.90.90.40.90.40.6-0.3
Distance moved, locomotor task time 10.40.61.3-0.9-0.6-1.1-0.7-0.9-0.6-0.7-1.0-0.5-1.0-0.1-0.80.0
Vertical activity count, locomotor time 10.92.13.3-1.5-1.1-1.6-1.4-1.8-1.2-1.3-1.8-1.0-1.7-0.3-1.61.7
Time >=10cm from walls, locomotor time 20.30.52.4-0.20.8-1.00.2-0.20.40.1-0.10.4-1.01.60.2-0.5
Bouts of movement, locomotor time 20.10.10.5-0.10.2-0.30.70.2-0.10.1-0.1-0.60.3-0.3-0.20.5
Total resting periods, locomotor time 20.20.41.80.40.70.11.30.70.30.70.4-0.30.9-0.00.40.3
Rest time, locomotor task time 21.82.34.21.62.11.11.21.31.91.41.52.00.51.81.6-0.6
Distance moved, locomotor task time 21.61.92.6-1.4-1.6-1.4-1.6-1.5-1.5-1.3-1.6-1.2-1.4-0.7-1.5-0.2
Vertical activity count, locomotor time 20.91.32.1-1.1-1.2-1.2-1.2-1.3-1.1-1.2-1.4-0.9-1.3-0.3-1.20.4
Light reinforcement 10.41.14.3-1.0-0.2-1.1-1.3-1.3-0.1-1.0-1.10.2-2.10.6-1.20.1
Light reinforcement 20.30.52.0-0.10.5-0.2-0.6-0.50.5-0.2-0.30.8-1.41.2-0.80.3
Bone: marrow area1.43.09.31.32.7-0.62.00.81.91.61.21.9-0.53.11.1-1.8
Bone: maximum diameter1.93.55.82.12.41.22.11.82.12.11.81.81.12.11.6-1.5
Bone: maximum force0.50.92.7-0.9-0.4-1.3-1.1-1.3-0.7-1.1-1.0-0.3-1.60.2-0.50.1
Bone: maximum moment0.30.51.4-0.6-0.3-0.9-0.8-1.0-0.5-0.8-0.7-0.2-1.20.2-0.4-0.0
Mean time between licks in bursts2.35.77.12.62.62.02.72.52.62.42.52.31.91.92.6-2.2
Mean num. licks in bursts2.74.37.5-2.2-2.7-1.3-2.1-1.8-2.6-1.9-2.0-2.6-0.8-2.5-1.71.7
Cd content in liver0.50.52.2-0.5-0.80.1-1.5-0.6-0.1-0.5-0.60.4-1.10.2-0.90.9
Co content in liver1.82.13.5-1.5-1.1-1.4-1.7-1.7-1.1-1.4-1.7-0.8-1.9-0.2-1.91.4
Cu content in liver1.51.84.1-1.2-1.8-0.3-1.1-0.8-1.5-1.4-1.2-1.50.1-2.0-1.61.6
Fe content in liver1.11.32.4-1.3-1.1-1.0-1.4-1.2-1.2-1.2-1.1-0.7-1.2-0.7-1.50.5
K content in liver0.30.31.10.80.41.10.30.70.60.40.50.70.70.10.20.3
Mg content in liver3.13.14.62.12.11.81.71.82.11.91.72.01.21.61.5-0.2
Mn content in liver4.04.47.92.32.71.41.92.02.62.12.12.80.62.71.8-1.3
Na content in liver0.50.51.3-0.6-0.6-0.4-0.2-0.4-0.8-0.8-0.6-0.90.1-1.1-1.10.6
Rb content in liver0.30.41.30.70.40.9-0.10.50.70.70.51.1-0.10.60.20.5
Se content in liver3.23.87.52.32.31.42.72.32.12.41.91.41.91.61.1-0.6
Sr content in liver0.20.20.70.40.50.00.20.40.60.40.40.6-0.10.8-0.3-0.4
Zn content in liver0.40.51.00.70.70.60.40.61.00.70.50.90.01.00.6-0.6
Bone: minimum diameter1.42.56.31.82.40.61.71.21.91.71.21.90.12.50.7-0.6
Time in familiar zone, hab. session 11.81.76.3-0.9-2.10.2-1.1-0.5-1.7-1.0-0.7-1.70.7-2.5-1.10.7
Time in novel zone, hab. session 10.90.93.70.41.6-0.50.90.21.20.70.31.0-0.61.90.7-0.9
Total zone transitions, hab. session 10.20.30.80.70.50.90.50.60.70.40.50.50.70.10.30.1
Total locomotion distance, hab. session 10.20.31.00.80.51.00.30.60.70.50.50.70.50.10.60.3
Locomotion velocity, hab. session 10.20.20.60.70.40.80.30.50.50.40.40.50.50.00.40.5
Time in familiar zone, hab. session 21.21.21.7-1.2-1.1-0.9-1.0-1.2-1.1-1.3-1.2-1.1-0.7-1.3-1.21.1
Time in novel zone, hab. session 20.20.20.90.20.10.10.30.40.10.50.3-0.00.30.40.4-0.9
Total zone transitions, hab. session 20.10.10.4-0.00.30.0-0.5-0.30.3-0.4-0.20.6-0.60.3-0.30.6
Total locomotion distance, hab. session 20.30.31.30.60.50.9-0.40.30.70.10.41.2-0.10.30.40.6
Locomotion velocity, hab. session 20.50.72.01.00.81.3-0.00.71.00.50.81.40.20.50.70.4
Novel to familiar place preference ratio0.20.20.60.3-0.10.40.40.50.10.30.5-0.10.7-0.20.6-0.8
Novelty place preference0.20.20.80.3-0.00.30.60.50.10.40.5-0.10.7-0.20.7-0.9
Time in novel zone, NPP test0.20.20.80.3-0.00.20.60.50.00.40.4-0.20.7-0.20.6-0.9
Total zone transitions, NPP test0.60.92.81.20.61.70.41.11.20.81.01.20.90.31.00.1
Total locomotion distance, NPP test0.50.72.50.90.31.6-0.40.70.90.40.71.30.30.40.70.6
Locomotion velocity, NPP test0.70.93.51.10.41.9-0.40.91.10.60.91.60.40.50.80.6
Intraocular pressure0.40.61.5-0.7-1.2-0.1-1.1-0.7-0.8-0.6-0.7-0.4-0.5-1.0-1.20.7
Delta distance traveled before/after self-admin0.50.62.0-0.7-0.5-1.20.5-0.5-1.0-0.5-0.7-1.40.3-0.7-0.8-0.2
Delta ambulatory time before/after self-admin0.30.31.2-0.5-0.1-1.00.6-0.4-0.7-0.3-0.6-1.10.3-0.4-0.4-0.1
Parametrial fat weight1.84.28.8-2.2-1.5-2.4-3.0-2.6-1.7-2.0-2.2-0.7-2.9-0.4-2.00.9
Pavlov. Cond. lever latency6.98.612.4-3.4-2.6-3.4-3.2-3.5-2.8-3.1-3.4-2.2-3.3-1.5-3.11.7
Pavlov. Cond. magazine entry latency2.63.46.82.01.61.72.62.31.42.02.00.92.60.41.9-1.1
Pavlov. Cond. change in total contacts1.51.63.61.61.21.21.91.51.11.31.30.61.70.51.3-0.3
Pavlov. Cond. index score5.36.79.83.02.42.73.03.12.42.82.91.93.01.32.7-1.4
Pavlov. Cond. latency score5.77.210.53.12.52.83.23.22.52.83.02.03.11.32.8-1.5
Pavlov. Cond. lever contacts6.37.510.43.22.63.02.73.12.92.83.12.62.61.92.9-1.5
Pavlov. Cond. magazine entry number1.92.45.0-1.7-1.3-1.5-2.1-1.9-1.3-1.7-1.7-0.8-2.2-0.4-1.60.8
Pavlov. Cond. intertrial magazine entries1.62.04.2-1.3-1.9-0.5-2.1-1.5-1.3-1.6-1.4-1.1-1.3-1.1-1.31.3
Pavlov. Cond. lever-magazine prob. diff.5.26.49.42.92.32.72.93.12.32.72.91.93.01.22.7-1.4
Pavlov. Cond. response bias3.64.56.52.42.02.22.52.62.02.32.41.62.51.02.2-1.1
Pavlov. Cond. lever latency0.60.82.40.51.2-0.10.40.31.20.70.51.3-0.61.51.1-0.7
Pavlov. Cond. magazine entry latency0.50.61.11.10.61.00.81.00.61.00.80.60.90.40.6-0.5
Pavlov. Cond. change in total contacts0.20.41.3-0.3-0.7-0.00.2-0.0-0.8-0.2-0.2-1.10.8-1.1-0.60.5
Pavlov. Cond. index score0.10.20.80.4-0.30.50.40.4-0.30.20.2-0.50.9-0.7-0.20.1
Pavlov. Cond. latency score0.10.20.50.2-0.40.30.30.2-0.40.00.0-0.60.7-0.7-0.30.2
Pavlov. Cond. lever contacts0.50.71.9-0.5-1.1-0.0-0.4-0.4-1.1-0.7-0.5-1.20.4-1.4-1.20.8
Pavlov. Cond. magazine entry number0.10.10.3-0.6-0.1-0.6-0.2-0.3-0.1-0.3-0.2-0.3-0.3-0.10.1-0.1
Pavlov. Cond. intertrial magazine entries0.71.02.01.01.20.71.41.01.20.81.00.70.90.61.4-0.6
Pavlov. Cond. lever-magazine prob. diff.0.10.20.60.3-0.30.40.30.3-0.30.10.1-0.40.8-0.6-0.30.2
Pavlov. Cond. response bias0.20.20.90.4-0.40.70.20.4-0.40.10.2-0.40.9-0.8-0.60.3
Time in closed arm before self-admin0.10.20.70.00.5-0.50.60.50.30.50.30.30.20.40.0-0.8
Time in closed arm after self-admin0.10.10.20.10.3-0.10.00.20.20.40.10.4-0.20.40.10.4
Time in open arm before self-admin0.70.82.50.70.21.01.11.10.40.91.0-0.11.6-0.30.9-1.0
Time in open arm after self-admin0.30.31.20.3-0.20.50.60.4-0.20.30.5-0.41.1-0.60.5-1.1
Bone: periosteal estimation0.61.23.80.81.8-0.71.30.31.01.00.61.0-0.52.00.6-1.2
Bone: periosteal perimeter0.71.23.21.21.80.11.50.91.21.10.81.00.31.60.3-0.7
Bone: post-yield work1.52.24.61.62.00.91.21.11.91.21.41.80.22.11.5-1.3
Progressive ratio test 1 active lever presses0.10.10.30.3-0.20.50.10.50.20.40.40.30.30.00.3-0.2
Progressive ratio test 1 breakpoint0.10.10.30.4-0.20.50.20.60.20.40.50.30.30.10.3-0.3
Progressive ratio test 1 inactive lever presses0.30.51.3-0.3-0.80.1-1.1-0.7-0.4-0.9-0.7-0.2-1.0-0.4-0.50.9
Progressive ratio test 2 active lever presses0.10.10.60.3-0.50.7-0.10.2-0.1-0.10.2-0.20.5-0.60.30.3
Progressive ratio test 2 breakpoint0.10.20.60.2-0.60.7-0.20.2-0.2-0.20.2-0.30.5-0.80.20.2
Progressive ratio test 2 inactive lever presses0.71.22.21.40.71.50.91.21.21.01.20.91.00.71.4-0.9
Incentive Sensitization - Responses0.20.20.80.60.10.80.40.50.20.10.5-0.10.9-0.40.40.3
Incentive Sensitization - Breakpoint0.10.20.60.5-0.00.80.20.30.1-0.10.3-0.10.8-0.50.30.4
Sum of active levers in priming session hrs 5-60.50.51.00.90.50.91.00.90.60.80.70.30.90.20.4-0.1
Progressive ratio3.35.210.9-2.8-1.4-3.3-1.9-2.7-2.3-2.0-2.5-1.9-2.7-0.8-2.61.1
Food seeking constrained by brief footshock0.30.30.8-0.3-0.9-0.1-0.4-0.4-0.8-0.7-0.5-0.90.1-0.9-0.60.1
Seeking ratio, punishment vs. effort2.23.26.02.21.02.51.82.21.61.42.01.12.40.42.0-1.1
Retroperitoneal fat weight0.10.62.1-0.7-0.5-0.5-1.4-0.9-0.4-0.9-0.70.2-1.20.1-0.60.7
Reaction time number correct1.32.54.4-2.1-1.6-1.8-1.6-1.9-1.6-2.1-1.8-1.7-1.3-1.2-0.8-0.4
Reaction time mean minus median1.22.94.51.91.61.91.82.11.92.11.81.71.71.10.01.2
Reaction time mean minus median AUC1.43.56.22.31.52.51.82.42.02.32.01.82.11.10.41.0
Reaction time num false alarms0.40.51.20.91.10.41.10.60.81.10.50.50.40.70.5-0.2
Reaction time num false alarms AUC0.30.51.80.81.20.11.30.50.70.80.40.30.40.60.4-0.2
Reaction time trials correct on left1.32.54.4-2.1-1.6-1.8-1.6-1.9-1.6-2.1-1.8-1.7-1.3-1.2-0.8-0.4
Reaction time trials on left1.32.44.1-2.0-1.6-1.7-1.5-1.8-1.6-2.0-1.7-1.7-1.2-1.2-0.8-0.4
Reaction time mean2.64.26.52.42.12.21.62.32.42.62.32.61.42.11.20.0
Reaction time mean AUC2.33.75.72.32.02.21.52.22.22.42.12.41.31.91.10.3
Median of all reaction times2.13.05.31.91.81.81.21.82.02.11.92.30.92.01.3-0.3
Reaction time omissions1.62.44.01.91.81.81.31.61.91.51.52.01.01.50.70.8
Reaction time false alarm rate1.82.45.12.02.01.22.31.61.62.01.41.21.31.31.0-0.1
Reaction time premature initiation rate0.10.21.6-0.1-0.0-0.2-0.3-0.1-0.1-0.10.20.2-0.40.30.1-1.3
Reaction time premature initiations0.71.32.1-1.5-1.0-1.4-1.2-1.2-1.1-1.3-0.9-0.8-1.2-0.4-0.3-1.4
Std. dev. reaction times2.34.37.22.42.22.12.42.52.32.72.22.02.01.60.60.6
Reaction time trials completed1.32.44.1-2.0-1.6-1.7-1.5-1.8-1.6-2.0-1.7-1.7-1.2-1.2-0.8-0.4
Reaction time trials AUC1.22.34.0-2.0-1.5-1.7-1.6-1.8-1.5-2.0-1.7-1.6-1.3-1.1-0.8-0.4
Run reversals in cocaine runway, females0.60.61.3-1.2-1.1-0.6-1.0-0.7-0.8-0.6-0.7-0.6-0.8-0.7-0.80.3
Run reversals in cocaine runway, males1.21.21.91.21.01.01.11.41.01.21.30.91.00.61.2-1.3
Latency to leave start box in cocaine runway1.61.83.11.41.41.11.01.21.61.21.41.80.81.41.4-1.3
Latency to leave start box in cocaine runway, F0.91.02.11.11.01.10.71.01.40.91.11.50.51.01.10.1
Latency to leave start box in cocaine runway, M0.70.74.50.60.90.10.30.30.60.40.60.80.30.90.7-2.1
Std. dev. time between licks in bursts4.45.99.52.63.11.52.82.32.72.62.42.51.52.52.4-2.2
Total sessions with >9 infusions0.20.31.1-0.2-0.80.10.20.3-0.50.20.0-0.70.4-0.80.11.1
Short access day 1 total inactive lever presses0.81.11.61.20.91.01.21.31.21.01.11.00.90.91.2-0.3
Short access day 10 total inactive lever presses0.20.51.00.81.00.80.20.31.00.20.30.9-0.40.80.21.0
Short access day 1 total infusions0.40.61.20.7-0.10.90.71.10.41.10.90.21.0-0.01.1-0.0
Short access day 10 total infusions0.30.32.50.0-0.80.5-0.30.2-0.30.1-0.1-0.40.3-0.7-0.11.6
Short access total infusions0.20.31.00.3-0.60.70.20.6-0.00.60.4-0.20.7-0.40.31.0
Short access day 1 locomotion0.50.71.20.70.50.70.61.00.90.91.10.90.60.31.11.0
Short access day 10 total locomotion0.30.51.70.11.1-0.90.9-0.10.6-0.00.00.5-0.91.30.5-0.6
Short access total locomotion0.30.30.90.30.7-0.10.60.40.70.40.50.7-0.30.90.80.4
One hour access (0.3 mA shock)0.40.51.70.90.21.30.30.90.50.60.70.61.0-0.30.40.5
Compulsive drug intake2.93.47.01.92.51.51.21.42.41.71.82.60.32.21.8-1.5
One hour access (shock baseline)0.81.23.0-0.8-1.7-0.1-0.8-0.4-1.4-0.8-0.8-1.40.5-1.7-1.11.2
Social response proportion0.30.41.50.10.9-0.40.60.20.60.60.40.5-0.41.20.6-0.3
Social responses0.20.20.6-0.40.7-0.80.6-0.10.20.1-0.00.0-0.40.6-0.50.7
Social time2.53.47.21.82.71.21.91.62.51.81.72.50.72.21.60.1
Soleus weight2.88.317.42.94.01.32.92.33.53.12.43.40.34.22.4-1.9
Bone: stiffness0.71.12.6-1.1-0.7-1.3-1.4-1.4-0.8-1.4-1.2-0.4-1.6-0.2-0.60.2
Tibialis anterior weight0.41.42.4-1.6-1.3-0.9-1.4-1.4-1.4-1.6-1.1-0.9-1.2-1.1-0.80.6
Time to tail flick, vehicle, before self-admin0.50.52.9-0.60.1-0.5-0.7-0.70.1-0.6-0.70.3-0.90.0-0.61.7
Time to tail flick, vehicle, after self-admin0.40.50.80.70.60.70.90.90.80.80.70.60.70.40.60.4
Time to tail flick, test, before self-admin0.50.51.4-0.9-0.6-0.7-0.2-0.4-0.7-0.6-0.8-0.8-0.2-1.1-1.20.3
Time to tail flick, test, after self-admin0.50.62.40.5-0.11.10.60.90.20.40.6-0.01.6-0.90.3-0.7
Delta time to tail flick, vehicle, before/after SA0.60.62.00.7-0.41.20.51.00.00.60.8-0.11.4-0.60.6-0.4
Delta time to tail flick, test, before/after SA0.10.10.80.4-0.00.9-0.30.20.30.10.30.50.40.00.40.0
Tibia length0.61.86.20.72.3-0.81.30.31.40.90.61.5-1.02.51.3-1.1
Ambulatory time before self-admin0.10.10.50.20.30.1-0.10.10.50.30.40.7-0.40.40.30.2
Ambulatory time after self-admin0.10.10.8-0.30.4-0.90.3-0.4-0.1-0.1-0.2-0.2-0.40.3-0.1-0.2
Bone: tissue strength0.10.10.30.0-0.20.2-0.4-0.3-0.0-0.3-0.20.1-0.50.3-0.50.4
Total heroin consumption0.10.10.30.20.50.10.40.20.40.20.20.20.20.30.00.3
Bone: trabecular number0.30.62.10.1-1.21.5-1.00.1-0.2-0.00.1-0.10.5-1.30.10.9
Bone: trabecular spacing0.40.52.6-0.40.8-1.60.7-0.4-0.0-0.1-0.4-0.3-0.71.1-0.5-0.1
Bone: trabecular thickness0.30.31.30.0-0.90.9-1.2-0.2-0.4-0.3-0.10.1-0.0-0.90.10.1
Bone: trabecular tissue density0.20.31.30.2-0.0-0.31.00.5-0.20.10.3-0.61.0-0.50.4-1.1
Water consumed over 24 hours0.30.40.70.60.90.20.60.50.70.50.60.70.20.80.6-0.6
Number of responses in last shaping day2.12.34.61.61.60.62.01.41.21.91.41.01.11.41.7-2.1