Hub : Genes

RT1-Ba

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression RT1-Ba 0.19 0.09 3.1e-06 0.11 0.11 0.08 0.11 2.5e-05 3.5e-05 2.4e-04 2.4e-05
2 PL gene expression RT1-Ba 0.1 0.05 4.5e-07 0.04 0.05 0.05 0.04 9.9e-05 1.8e-06 9.3e-06 3.3e-05
3 pVTA gene expression RT1-Ba 0.08 0.04 1.4e-05 0.06 0.05 0.03 0.05 2.4e-05 1.2e-04 1.6e-03 8.1e-05
4 Adipose mRNA stability RT1-Ba 0.72 0.07 0.0e+00 0.52 0.59 0.67 0.64 1.5e-66 2.9e-81 4.7e-100 6.8e-94
5 IL gene expression RT1-Ba 0.24 0.13 6.7e-03 0.07 0.11 0.07 0.07 9.0e-03 1.5e-03 7.5e-03 1.0e-02
6 Brain gene expression RT1-Ba 0.28 0.12 0.0e+00 0.08 0.19 0.17 0.18 8.2e-08 3.8e-17 4.5e-16 2.1e-16
7 LHb gene expression RT1-Ba 0.37 0.15 1.2e-04 0.06 0.12 0.16 0.22 1.3e-02 8.8e-04 1.7e-04 6.3e-06
8 pVTA intron excision ratio chr20_4577203_4579882 0.04 0.02 4.8e-03 0.01 0.02 0.01 0.01 2.8e-02 1.6e-02 2.8e-02 2.1e-02
9 Liver mRNA stability RT1-Ba 0.69 0.05 0.0e+00 0.52 0.68 0.76 0.76 4.6e-68 1.2e-103 5.7e-130 6.6e-127
10 Adipose gene expression RT1-Ba 0.58 0.1 0.0e+00 0.51 0.56 0.57 0.57 3.5e-66 3.1e-74 2.0e-77 5.1e-77
11 Liver gene expression RT1-Ba 0.12 0.05 3.4e-12 0.11 0.1 0.11 0.12 2.1e-12 6.0e-11 1.6e-12 1.0e-12
12 BLA gene expression RT1-Ba 0.1 0.06 2.6e-03 0.03 0.04 0.01 0.03 1.7e-02 5.0e-03 6.1e-02 9.8e-03
13 NAcc gene expression RT1-Ba 0.05 0.03 2.8e-07 0.03 0.05 0.05 0.05 6.4e-05 1.5e-07 1.0e-07 8.4e-08
14 pVTA intron excision ratio chr20_4580835_4581082 0.04 0.02 6.8e-03 0 0.01 0.02 0 1.5e-01 2.1e-02 1.6e-02 1.5e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.20.41.70.2-0.9-1.3-0.2-0.8-0.1-0.00.2-0.3-0.00.5-1.10.5-0.4
Area under the delay curve0.10.10.4-0.40.00.70.00.3-0.4-0.2-0.40.10.40.1-0.0-0.2-0.1
BMI with tail1.34.610.5-2.3-1.42.52.9-2.9-1.8-2.5-1.42.51.0-3.2-0.4-2.0-0.9
BMI without tail0.94.910.4-2.4-1.43.22.6-1.8-2.2-2.3-2.32.51.9-2.4-0.8-2.8-1.3
Body weight1.14.613.0-2.1-0.23.62.8-1.8-1.4-2.0-1.42.50.5-3.61.2-2.6-1.1
Weight adjusted by age0.10.31.3-0.20.30.90.50.00.0-0.1-0.00.4-0.1-1.11.1-0.40.2
Bone surface0.30.62.50.60.8-0.4-0.50.50.80.60.6-0.8-0.70.30.61.61.1
Bone volume0.00.10.50.1-0.2-0.30.0-0.3-0.0-0.10.0-0.2-0.10.0-0.30.70.4
Breakpoint value in progressive ratio session0.20.30.60.60.6-0.7-0.60.60.60.70.4-0.7-0.50.40.20.80.3
Number of licking bursts0.82.33.71.71.9-1.2-1.51.81.81.31.4-1.6-1.61.11.51.31.3
Context. condit. distance diff. score6.57.911.43.32.7-3.2-3.12.33.13.13.4-3.0-3.32.32.12.41.1
Locomotion velocity, session 11.71.94.11.70.9-1.5-1.71.71.11.51.0-1.5-0.52.00.31.61.0
Locomotion distance, session 10.20.20.90.3-0.3-1.0-0.4-0.20.20.10.3-0.2-0.00.7-0.60.0-0.7
Locomotion velocity, session 20.60.71.31.00.8-0.8-1.00.90.80.90.7-0.9-0.70.90.41.10.6
Locomotion distance, session 20.30.51.30.80.3-1.1-0.7-0.10.70.51.2-0.7-0.90.40.40.70.1
Locomotion velocity, session 30.70.81.5-0.9-0.90.70.6-0.4-1.1-1.0-1.10.91.1-0.0-1.2-1.20.0
Locomotion distance, session 30.30.31.40.5-0.2-1.2-0.70.20.20.20.4-0.4-0.21.0-0.7-0.0-0.2
Stereotopy head waving bouts, day 30.40.51.60.21.10.7-0.20.90.70.50.2-0.2-0.5-0.21.30.51.1
Stereotopy head waving duration, day 30.20.31.6-0.10.60.8-0.10.80.10.3-0.2-0.10.20.00.70.21.3
Locomotion velocity, session 71.21.35.01.30.2-2.2-1.2-0.11.00.81.8-1.2-1.51.00.20.9-0.0
Locomotion distance, session 71.31.76.71.6-0.1-2.6-1.60.40.91.01.5-1.4-1.11.9-0.51.0-0.1
Stereotopy head waving bouts, day 70.40.51.4-0.2-0.10.5-0.20.9-0.60.1-1.00.01.21.0-0.8-0.40.7
Stereotopy head waving duration, day 70.30.41.3-0.6-0.20.90.30.4-0.7-0.2-1.10.41.10.3-0.5-0.60.5
Locomotion velocity, session 85.26.38.92.83.0-2.0-2.62.82.82.82.5-2.5-2.51.72.52.61.8
Locomotion distance, session 84.87.012.83.12.5-3.3-2.71.73.12.63.6-2.7-3.41.72.12.30.7
Degree of sensitization distance1.11.11.81.21.2-0.8-0.91.01.31.01.2-1.0-1.30.41.21.30.5
Degree of sensitization stereotypy0.40.51.90.1-0.2-0.1-0.50.8-0.50.2-0.8-0.21.11.4-1.1-0.10.4
Conditioned locomotion0.40.41.4-0.10.80.50.4-0.10.5-0.10.5-0.1-0.9-1.01.20.70.9
Cocaine response after cond. corrected0.40.72.70.60.7-0.7-0.1-0.51.00.21.3-0.3-1.6-0.81.20.30.3
Cocaine response after cond. not corrected0.50.72.50.71.3-0.1-0.20.41.10.60.9-0.4-1.3-0.61.60.40.7
Cocaine response before conditioning0.50.62.4-0.40.61.60.31.3-0.30.1-1.20.41.0-0.00.3-0.20.6
Saline control response4.86.710.1-3.0-2.63.12.7-2.1-3.1-2.5-3.22.63.1-1.8-2.2-2.2-1.0
Bone: connectivity density0.30.41.60.4-0.2-1.3-0.3-0.60.50.50.8-0.6-0.70.2-0.11.1-0.1
Bone: cortical apparent density1.82.94.7-2.0-1.71.82.2-2.1-1.9-2.1-1.81.81.5-1.8-1.2-0.6-0.2
Bone: cortical area0.00.00.20.10.40.40.10.2-0.1-0.0-0.10.10.1-0.10.3-0.10.1
Bone: cortical porosity0.80.83.70.0-0.10.0-0.91.5-0.50.5-0.9-0.41.41.9-1.1-0.20.5
Bone: cortical porosity0.91.04.30.60.5-0.3-1.32.00.10.9-0.3-0.80.82.1-0.40.30.7
Bone: cortical thickness1.72.84.1-1.7-1.71.41.8-1.7-2.0-1.9-1.91.81.9-1.0-1.7-1.5-1.1
Bone: cortical thickness3.44.15.8-2.4-2.12.32.4-2.3-2.3-2.4-2.22.21.9-1.8-1.7-1.0-0.3
Bone: cortical tissue density1.62.64.3-1.9-1.61.72.1-1.9-1.8-2.0-1.71.71.4-1.7-1.1-0.4-0.0
Condit. Reinf. active minus inactive responses0.30.41.70.6-0.3-0.9-0.70.70.00.3-0.1-0.50.61.3-0.70.5-0.4
Condit. Reinf. active-inactive response ratio0.70.81.8-0.8-1.00.70.7-0.4-1.0-0.7-1.20.81.3-0.1-1.0-0.8-1.1
Condit. Reinf. active responses0.20.31.00.5-0.6-1.0-0.40.1-0.00.00.0-0.10.30.7-0.70.2-1.0
Condit. Reinf. inactive responses0.30.41.30.2-0.9-1.2-0.0-0.7-0.2-0.40.20.10.00.3-0.9-0.1-1.2
Incentive salience index mean1.62.13.81.81.1-1.9-1.71.31.41.51.5-1.7-1.11.60.71.60.3
Condit. Reinf. lever presses3.85.89.52.72.3-2.9-2.41.62.72.43.1-2.6-2.91.52.02.40.8
Condit. Reinf. active minus inactive responses0.10.10.4-0.10.10.60.10.5-0.30.1-0.50.30.4-0.10.0-0.4-0.3
Condit. Reinf. active-inactive response ratio0.20.21.10.50.80.3-0.31.10.40.70.1-0.2-0.10.10.8-0.00.0
Condit. Reinf. active responses0.10.10.3-0.2-0.20.30.10.2-0.3-0.1-0.50.20.60.1-0.4-0.4-0.3
Condit. Reinf. inactive responses0.50.71.1-1.0-1.00.60.8-0.9-0.9-1.1-0.90.70.9-0.5-1.0-0.6-0.4
Condit. Reinf. lever presses0.20.31.70.5-0.3-0.9-0.60.6-0.20.2-0.2-0.30.51.3-0.9-0.2-0.4
Condit. Reinf. lever reinforcers received0.10.10.30.1-0.10.1-0.10.5-0.20.1-0.50.00.50.4-0.4-0.2-0.4
Conditioned reinforcement - actives0.10.21.1-0.2-0.6-0.10.3-0.5-0.4-0.5-0.20.40.2-0.3-0.5-0.0-1.0
Conditioned reinforcement - inactives0.00.10.40.1-0.6-0.00.1-0.3-0.3-0.3-0.20.20.4-0.1-0.4-0.2-0.3
Conditioned locomotion0.10.10.20.3-0.0-0.4-0.40.20.20.30.5-0.4-0.40.20.20.50.1
Patch foraging indifference point 0 sec1.43.95.7-2.4-2.02.22.1-1.7-2.2-2.2-2.42.02.1-1.7-1.4-1.6-1.2
Patch foraging indifference point AUC0.10.10.5-0.10.20.5-0.20.7-0.10.3-0.6-0.00.50.4-0.20.50.2
Delay disc. indifference point, 0s delay0.40.51.10.70.9-0.6-0.60.60.80.50.9-0.7-0.80.11.00.80.4
Delay disc. indifference point, 16s delay0.50.71.5-1.1-1.00.90.6-0.6-1.2-0.9-1.00.71.1-0.0-1.0-0.7-0.0
Delay disc. indifference point, 2s delay0.40.51.60.50.90.1-0.81.30.50.90.4-0.6-0.30.60.90.6-0.1
Delay disc. indifference point, 24s delay0.30.41.5-0.6-0.70.80.30.2-0.9-0.6-1.00.41.20.3-0.6-0.40.3
Delay disc. indifference point, 4s delay0.20.21.2-0.60.21.10.40.3-0.4-0.4-0.70.30.4-0.40.2-0.2-0.0
Delay disc. indifference point, 8s delay0.00.00.2-0.2-0.10.30.00.1-0.4-0.1-0.20.10.40.2-0.1-0.1-0.1
Indifference point function ln k0.31.02.30.81.1-0.8-1.01.20.90.90.8-1.1-0.81.00.61.21.5
Indifference point function log k0.31.02.30.81.1-0.8-1.01.20.90.90.8-1.1-0.81.00.61.21.5
Patch foraging total patch changes 0 sec1.44.26.2-2.5-2.12.32.2-1.8-2.3-2.4-2.52.12.3-1.7-1.5-1.6-1.0
Patch foraging total patch changes 12 sec1.82.44.3-2.0-1.51.91.6-1.1-1.7-1.6-2.11.61.8-1.3-1.2-0.5-0.3
Patch foraging total patch changes 18 sec2.25.27.4-2.7-2.52.22.5-2.7-2.5-2.7-2.32.32.0-2.1-1.9-1.7-1.3
Patch foraging total patch changes 24 sec0.82.65.2-1.6-2.30.91.4-1.9-2.0-1.5-1.71.51.7-0.7-2.0-1.4-1.5
Patch foraging total patch changes 6 sec2.33.85.4-2.3-2.12.12.0-1.8-2.3-1.9-2.32.02.2-1.5-1.6-1.6-1.4
Patch foraging time to switch 0 sec0.41.44.5-1.0-0.80.61.5-2.1-0.7-1.2-0.01.2-0.2-2.00.1-1.4-0.9
Patch foraging water rate 0 sec0.00.10.3-0.3-0.10.60.3-0.1-0.2-0.3-0.20.40.2-0.40.3-0.10.4
Patch foraging water rate 12 sec0.10.51.1-0.6-1.00.20.5-0.8-0.9-0.8-0.80.50.7-0.0-1.1-0.4-0.4
Patch foraging water rate 18 sec0.20.50.8-0.7-0.70.60.8-0.7-0.8-0.8-0.70.80.6-0.7-0.4-0.9-0.3
Patch foraging water rate 24 sec0.40.51.2-0.7-0.70.50.8-0.7-0.7-1.1-0.80.70.5-0.5-0.7-0.7-0.8
Patch foraging water rate 6 sec0.30.41.0-0.7-0.60.60.7-0.8-0.6-0.7-0.60.80.4-0.7-0.4-1.0-0.4
Seeking ratio, delayed vs. immediate footshock1.01.43.8-1.2-0.51.71.1-0.1-1.1-0.6-2.01.21.4-0.8-0.9-1.1-1.3
Distance traveled before self-admin0.20.41.30.30.70.10.1-0.30.70.20.7-0.3-1.1-1.11.10.2-0.1
Distance traveled after self-admin0.20.31.4-0.50.41.20.7-0.0-0.2-0.3-0.70.50.1-0.90.5-0.50.2
Extensor digitorum longus weight0.21.02.40.91.3-0.6-0.90.81.21.01.3-1.0-1.60.11.40.40.1
Bone: elastic displacement0.50.61.7-0.4-1.20.10.3-0.3-1.1-0.3-1.00.61.20.4-1.3-0.8-0.6
Bone: elastic work0.10.10.4-0.3-0.40.40.3-0.3-0.7-0.0-0.50.30.6-0.2-0.4-0.20.2
Bone: endosteal estimation1.33.29.61.42.80.4-1.02.12.01.81.4-1.3-2.0-0.43.11.11.8
Bone: endosteal perimeter1.94.69.52.33.1-1.0-1.82.32.72.22.3-1.9-2.50.43.11.21.4
Epididymis fat weight5.125.743.7-5.6-5.34.35.8-6.6-5.2-5.9-4.35.53.7-5.1-3.7-5.0-3.7
Delta time in closed arm before/after self-admin0.20.20.80.20.4-0.10.2-0.20.40.20.50.1-0.4-0.60.90.6-0.3
Delta time in open arm before/after self-admin0.20.20.7-0.4-0.70.30.4-0.3-0.7-0.4-0.70.20.60.1-0.8-0.30.2
Diff in mean of infusions in LGA sessions0.50.92.11.00.7-1.5-0.90.21.10.81.4-0.9-1.30.60.50.80.1
Delay discount exponential model param0.10.10.50.4-0.0-0.7-0.0-0.40.50.20.5-0.1-0.5-0.20.10.20.1
Extinction: sum of active levers before priming0.81.32.11.11.2-1.0-1.11.01.31.11.2-1.3-1.30.51.11.50.6
Active lever presses in extinction session 60.10.20.5-0.1-0.7-0.50.1-0.6-0.4-0.20.00.00.40.2-0.5-0.2-0.5
Bone: final force1.52.56.1-1.6-0.92.12.1-1.8-1.3-1.6-1.21.80.7-2.5-0.0-1.6-0.9
Bone: final moment1.21.94.2-1.4-0.91.81.8-1.6-1.2-1.4-1.11.60.7-2.0-0.1-1.5-0.9
Food consumed during 24 hour testing period0.30.62.60.21.00.30.2-0.20.80.10.9-0.2-1.3-1.11.60.10.6
Glucose5.89.213.33.63.5-2.6-3.33.53.63.43.4-3.0-3.22.13.31.41.0
Heart weight0.20.41.5-0.30.11.20.50.6-0.5-0.1-0.70.70.9-0.10.3-1.0-0.5
Delay discount hyperbolic model param0.10.10.50.4-0.1-0.70.1-0.50.40.10.5-0.0-0.5-0.30.10.20.3
Intermittent access intake day 1-15 change0.00.20.4-0.6-0.10.70.20.1-0.3-0.5-0.60.40.6-0.0-0.3-0.20.1
Intermittent access intake escalation0.21.22.5-1.3-1.11.20.8-0.5-1.3-1.2-1.51.11.6-0.3-1.3-0.9-0.3
Intermittent access intake escalation 20.10.10.70.00.20.0-0.30.60.0-0.1-0.1-0.10.30.5-0.10.40.9
Intermitt. access day 1 inactive lever presses0.22.14.31.82.1-1.3-1.11.22.00.91.6-1.2-1.80.02.11.10.4
Intermitt. access day 15 inactive lever presses0.00.10.3-0.00.20.50.2-0.00.10.1-0.00.1-0.0-0.50.4-0.0-0.0
Intermitt. access escalation Index0.51.42.71.41.3-1.6-1.10.71.51.31.4-1.2-1.60.70.91.00.1
Intermittent access day 1 total infusions0.30.82.91.1-0.4-1.7-1.10.30.30.90.9-0.9-0.31.4-0.40.9-0.0
Intermittent access day 15 total infusions0.20.41.6-0.5-1.1-0.00.0-0.3-0.8-0.4-0.60.41.00.4-1.3-0.2-0.4
Intermittent access terminal intake (last 3 days)0.20.41.2-0.4-1.00.0-0.1-0.1-0.7-0.3-0.60.31.00.6-1.1-0.1-0.3
Intermittent access total infusions0.20.31.00.0-0.9-0.5-0.3-0.1-0.50.0-0.20.00.70.7-1.00.0-0.3
Intermittent access day 1 locomotion0.10.20.60.0-0.8-0.40.1-0.6-0.3-0.20.10.10.1-0.2-0.5-0.2-0.8
Intermittent access day 15 total locomotion0.20.61.3-0.8-0.61.10.9-0.7-0.7-0.8-0.71.00.6-1.1-0.2-0.8-0.6
Intermittent access total locomotion0.50.61.2-0.7-1.10.60.7-0.8-1.0-1.0-0.70.90.9-0.7-0.8-0.6-0.8
Intermittent access standard deviation0.52.53.8-1.8-1.41.91.7-1.4-1.6-1.9-1.71.71.6-1.8-0.8-1.3-0.9
Left kidney weight0.86.613.6-3.0-1.13.73.3-2.2-2.4-2.9-2.53.01.8-3.1-0.2-2.9-1.6
Right kidney weight0.96.012.4-2.9-0.83.43.2-2.2-1.9-2.7-2.02.91.2-3.50.3-2.9-1.6
Cocaine induced anxiety0.20.51.30.31.0-0.1-0.30.41.00.30.8-0.5-1.1-0.41.00.70.2
Post-drug Anxiety0.20.20.6-0.40.60.60.20.10.4-0.10.20.1-0.4-0.80.60.0-0.8
Baseline Anxiety0.10.20.6-0.7-0.30.70.4-0.2-0.4-0.3-0.40.50.5-0.2-0.2-0.2-0.5
Tail length0.21.04.10.21.71.7-0.22.00.50.5-0.4-0.0-0.1-0.11.7-0.80.1
Length with tail0.31.36.50.01.92.00.31.30.60.4-0.00.2-0.7-1.22.5-0.70.1
Length without tail0.42.08.4-0.51.41.81.3-0.70.5-0.50.60.7-1.5-2.92.8-0.40.7
Times rat made contact with spout1.61.95.3-1.1-1.90.30.7-0.9-1.8-1.2-1.71.02.00.5-2.3-1.1-0.9
Lifetime Intake0.20.20.8-0.1-0.9-0.4-0.2-0.1-0.50.1-0.20.00.60.5-0.80.0-0.7
Liver weight, left0.91.66.01.12.10.1-0.41.21.70.81.2-0.6-1.8-0.62.50.00.4
Liver weight, right1.83.17.51.52.5-0.1-1.21.92.11.81.7-1.4-2.20.02.72.01.3
Locomotor activity0.20.41.3-0.30.81.1-0.01.00.10.1-0.70.20.3-0.10.4-1.0-0.6
Locomotor testing distance0.10.20.70.10.80.6-0.10.70.40.3-0.1-0.0-0.4-0.40.7-0.7-0.0
Locomotor testing rearing0.10.31.30.10.80.50.10.20.50.50.20.0-0.8-0.91.2-0.3-0.2
Locomotion in novel chamber0.10.10.3-0.5-0.30.20.4-0.4-0.5-0.4-0.40.20.2-0.4-0.3-0.40.1
Locomotion in novel chamber post-restriction0.41.12.6-1.2-0.71.61.3-1.1-1.0-1.1-0.91.20.6-1.2-0.2-1.0-0.6
Fecal boli incidents, locomotor time 10.10.20.60.4-0.1-0.8-0.4-0.30.30.20.8-0.7-0.60.10.10.6-0.1
Change in fecal boli incidents, locomotor task0.60.62.20.51.30.2-0.21.01.00.70.4-0.3-0.7-0.41.50.50.6
Time >=10cm from walls, locomotor time 10.81.04.3-0.21.41.00.7-0.10.9-0.10.7-0.0-1.3-1.72.10.50.1
Bouts of movement, locomotor time 10.10.10.30.20.3-0.5-0.30.40.20.00.0-0.30.10.5-0.3-0.1-0.1
Total resting periods, locomotor time 10.10.10.40.40.4-0.5-0.40.50.40.20.2-0.5-0.10.7-0.10.10.3
Rest time, locomotor task time 10.30.51.00.80.8-0.5-1.00.90.60.90.6-0.9-0.40.90.40.60.3
Distance moved, locomotor task time 10.20.61.3-0.9-0.61.10.9-0.7-0.6-0.7-0.71.00.5-1.0-0.1-0.8-0.0
Vertical activity count, locomotor time 10.32.13.3-1.5-1.11.61.8-1.4-1.2-1.3-1.21.81.0-1.7-0.3-1.6-1.7
Time >=10cm from walls, locomotor time 20.10.42.4-0.20.81.00.20.20.40.10.30.1-0.4-1.01.60.20.5
Bouts of movement, locomotor time 20.00.10.5-0.10.20.3-0.20.7-0.10.1-0.60.10.60.3-0.3-0.2-0.5
Total resting periods, locomotor time 20.10.41.80.40.7-0.1-0.71.30.30.7-0.3-0.40.30.9-0.00.4-0.3
Rest time, locomotor task time 21.42.34.21.62.1-1.1-1.31.21.91.41.8-1.5-2.00.51.81.60.6
Distance moved, locomotor task time 21.41.82.6-1.4-1.61.41.5-1.6-1.5-1.3-1.11.61.2-1.4-0.7-1.50.2
Vertical activity count, locomotor time 20.51.22.1-1.1-1.21.21.3-1.2-1.1-1.2-0.81.40.9-1.3-0.3-1.2-0.4
Light reinforcement 10.21.04.3-1.0-0.21.11.3-1.3-0.1-1.0-0.21.1-0.2-2.10.6-1.2-0.1
Light reinforcement 20.20.52.0-0.10.50.20.5-0.60.5-0.20.60.3-0.8-1.41.2-0.8-0.3
Bone: marrow area1.22.99.31.32.70.6-0.82.01.91.61.3-1.2-1.9-0.53.11.11.8
Bone: maximum diameter1.73.55.82.12.4-1.2-1.82.12.12.11.9-1.8-1.81.12.11.61.5
Bone: maximum force0.40.92.7-0.9-0.41.31.3-1.1-0.7-1.1-0.61.00.3-1.60.2-0.5-0.1
Bone: maximum moment0.20.41.4-0.6-0.30.91.0-0.8-0.5-0.8-0.40.70.2-1.20.2-0.40.0
Mean time between licks in bursts0.95.67.12.62.6-2.0-2.52.72.62.42.2-2.5-2.31.91.92.62.2
Mean num. licks in bursts1.64.37.5-2.2-2.71.31.8-2.1-2.6-1.9-2.22.02.6-0.8-2.5-1.7-1.7
Cd content in liver0.50.52.2-0.5-0.8-0.10.6-1.5-0.1-0.50.60.6-0.4-1.10.2-0.9-0.9
Co content in liver1.72.03.5-1.5-1.11.41.7-1.7-1.1-1.4-0.91.70.8-1.9-0.2-1.9-1.4
Cu content in liver1.51.84.1-1.2-1.80.30.8-1.1-1.5-1.4-1.31.21.50.1-2.0-1.6-1.6
Fe content in liver1.01.32.4-1.3-1.11.01.2-1.4-1.2-1.2-0.91.20.7-1.2-0.7-1.5-0.5
K content in liver0.40.31.10.80.4-1.1-0.70.30.60.40.8-0.5-0.70.70.10.2-0.3
Mg content in liver2.93.24.62.12.1-1.8-1.81.72.11.92.0-1.7-2.01.21.61.50.2
Mn content in liver4.14.67.92.32.7-1.4-2.01.92.62.12.6-2.1-2.80.62.71.81.3
Na content in liver0.50.51.3-0.6-0.60.40.4-0.2-0.8-0.8-1.00.60.90.1-1.1-1.1-0.6
Rb content in liver0.40.41.30.70.4-0.9-0.5-0.10.70.71.0-0.5-1.1-0.10.60.2-0.5
Se content in liver3.13.77.52.32.3-1.4-2.32.72.12.41.6-1.9-1.41.91.61.10.6
Sr content in liver0.30.20.70.40.5-0.0-0.40.20.60.40.8-0.4-0.6-0.10.8-0.30.4
Zn content in liver0.40.51.10.70.7-0.6-0.60.41.00.71.0-0.5-0.90.11.00.60.6
Bone: minimum diameter1.32.56.31.82.4-0.6-1.21.71.91.71.7-1.2-1.90.12.50.70.6
Time in familiar zone, hab. session 11.51.76.3-0.9-2.1-0.20.5-1.1-1.7-1.0-1.30.71.70.7-2.5-1.1-0.7
Time in novel zone, hab. session 10.80.93.70.41.60.5-0.20.91.20.70.7-0.3-1.0-0.61.90.70.9
Total zone transitions, hab. session 10.20.30.80.70.5-0.9-0.60.50.70.40.5-0.5-0.50.70.10.3-0.1
Total locomotion distance, hab. session 10.30.41.00.80.5-1.0-0.60.30.70.50.7-0.5-0.70.50.10.6-0.3
Locomotion velocity, hab. session 10.20.20.60.70.4-0.8-0.50.30.50.40.5-0.4-0.50.50.00.4-0.5
Time in familiar zone, hab. session 21.11.32.1-1.2-1.10.91.2-1.0-1.1-1.3-1.41.21.1-0.7-1.3-1.2-1.1
Time in novel zone, hab. session 20.10.10.90.20.1-0.1-0.40.30.10.50.3-0.30.00.30.40.40.9
Total zone transitions, hab. session 20.10.10.4-0.00.3-0.00.3-0.50.3-0.40.30.2-0.6-0.60.3-0.3-0.6
Total locomotion distance, hab. session 20.30.41.30.60.5-0.9-0.3-0.40.70.10.9-0.4-1.2-0.10.30.4-0.6
Locomotion velocity, hab. session 20.50.72.01.00.8-1.3-0.7-0.01.00.51.2-0.8-1.40.20.50.7-0.4
Novel to familiar place preference ratio0.10.20.60.3-0.1-0.4-0.50.40.10.30.1-0.50.10.7-0.20.60.8
Novelty place preference0.20.20.80.3-0.0-0.3-0.50.60.10.4-0.0-0.50.10.7-0.20.70.9
Time in novel zone, NPP test0.20.20.80.3-0.0-0.2-0.50.60.00.4-0.1-0.40.20.7-0.20.60.9
Total zone transitions, NPP test0.71.02.81.20.6-1.7-1.10.41.20.81.4-1.0-1.20.90.31.0-0.1
Total locomotion distance, NPP test0.60.82.50.90.3-1.6-0.7-0.40.90.41.5-0.7-1.30.30.40.7-0.6
Locomotion velocity, NPP test0.81.13.51.10.4-1.9-0.9-0.41.10.61.8-0.9-1.60.40.50.8-0.6
Intraocular pressure0.40.61.5-0.7-1.20.10.7-1.1-0.8-0.6-0.50.70.4-0.5-1.0-1.2-0.7
Delta distance traveled before/after self-admin0.60.72.3-0.7-0.51.20.50.5-1.0-0.5-1.50.71.40.3-0.7-0.80.2
Delta ambulatory time before/after self-admin0.20.41.6-0.5-0.11.00.40.6-0.7-0.3-1.30.61.10.3-0.4-0.40.1
Parametrial fat weight1.74.08.8-2.2-1.52.42.6-3.0-1.7-2.0-1.22.20.7-2.9-0.4-2.0-0.9
Pavlov. Cond. lever latency6.88.612.4-3.4-2.63.43.5-3.2-2.8-3.1-2.93.42.2-3.3-1.5-3.1-1.7
Pavlov. Cond. magazine entry latency2.53.26.82.01.6-1.7-2.32.61.42.01.2-2.0-0.92.60.41.91.1
Pavlov. Cond. change in total contacts1.41.63.61.61.2-1.2-1.51.91.11.30.8-1.3-0.61.70.51.30.3
Pavlov. Cond. index score5.26.69.83.02.4-2.7-3.13.02.42.82.3-2.9-1.93.01.32.71.4
Pavlov. Cond. latency score5.67.110.53.12.5-2.8-3.23.22.52.82.4-3.0-2.03.11.32.81.5
Pavlov. Cond. lever contacts6.37.610.43.22.6-3.0-3.12.72.92.83.0-3.1-2.62.61.92.91.5
Pavlov. Cond. magazine entry number1.82.35.0-1.7-1.31.51.9-2.1-1.3-1.7-1.01.70.8-2.2-0.4-1.6-0.8
Pavlov. Cond. intertrial magazine entries1.61.94.2-1.3-1.90.51.5-2.1-1.3-1.6-0.91.41.1-1.3-1.1-1.3-1.3
Pavlov. Cond. lever-magazine prob. diff.5.16.39.42.92.3-2.7-3.12.92.32.72.3-2.9-1.93.01.22.71.4
Pavlov. Cond. response bias3.64.46.52.42.0-2.2-2.62.52.02.31.9-2.4-1.62.51.02.21.1
Pavlov. Cond. lever latency0.60.82.40.51.20.1-0.30.41.20.71.0-0.5-1.3-0.61.51.10.7
Pavlov. Cond. magazine entry latency0.40.61.11.10.6-1.0-1.00.80.61.00.8-0.8-0.60.90.40.60.5
Pavlov. Cond. change in total contacts0.20.41.3-0.3-0.70.00.00.2-0.8-0.2-0.90.21.10.8-1.1-0.6-0.5
Pavlov. Cond. index score0.10.20.80.4-0.3-0.5-0.40.4-0.30.2-0.2-0.20.50.9-0.7-0.2-0.1
Pavlov. Cond. latency score0.10.20.50.2-0.4-0.3-0.20.3-0.40.0-0.3-0.00.60.7-0.7-0.3-0.2
Pavlov. Cond. lever contacts0.50.71.9-0.5-1.10.00.4-0.4-1.1-0.7-0.90.51.20.4-1.4-1.2-0.8
Pavlov. Cond. magazine entry number0.10.10.3-0.6-0.10.60.3-0.2-0.1-0.3-0.40.20.3-0.3-0.10.10.1
Pavlov. Cond. intertrial magazine entries0.40.92.01.01.2-0.7-1.01.41.20.80.6-1.0-0.70.90.61.40.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.60.3-0.3-0.4-0.30.3-0.30.1-0.2-0.10.40.8-0.6-0.3-0.2
Pavlov. Cond. response bias0.20.20.90.4-0.4-0.7-0.40.2-0.40.1-0.1-0.20.40.9-0.8-0.5-0.3
Time in closed arm before self-admin0.10.20.70.00.50.5-0.50.60.30.50.2-0.3-0.30.20.40.00.8
Time in closed arm after self-admin0.10.10.20.10.30.1-0.20.00.20.40.4-0.1-0.4-0.20.40.1-0.4
Time in open arm before self-admin0.60.72.50.70.2-1.0-1.11.10.40.90.2-1.00.11.6-0.30.91.0
Time in open arm after self-admin0.30.31.20.3-0.2-0.5-0.40.6-0.20.3-0.3-0.50.41.1-0.60.51.1
Bone: periosteal estimation0.51.13.80.81.80.7-0.31.31.01.00.6-0.6-1.0-0.52.00.61.2
Bone: periosteal perimeter0.61.13.21.21.8-0.1-0.91.51.21.10.9-0.8-1.00.31.60.30.7
Bone: post-yield work1.32.34.61.62.0-0.9-1.11.21.91.21.9-1.4-1.80.22.11.51.3
Progressive ratio test 1 active lever presses0.10.10.30.3-0.2-0.5-0.50.10.20.40.5-0.4-0.30.30.00.30.2
Progressive ratio test 1 breakpoint0.10.10.30.4-0.2-0.5-0.60.20.20.40.5-0.5-0.30.30.10.30.3
Progressive ratio test 1 inactive lever presses0.20.41.3-0.3-0.8-0.10.7-1.1-0.4-0.9-0.10.70.2-1.0-0.4-0.5-0.9
Progressive ratio test 2 active lever presses0.10.10.60.3-0.5-0.7-0.2-0.1-0.1-0.10.1-0.20.20.5-0.60.3-0.3
Progressive ratio test 2 breakpoint0.10.20.60.2-0.6-0.7-0.2-0.2-0.2-0.2-0.0-0.20.30.5-0.80.2-0.2
Progressive ratio test 2 inactive lever presses0.41.22.21.40.7-1.5-1.20.91.21.01.3-1.2-0.91.00.71.40.9
Incentive Sensitization - Responses0.10.20.80.60.1-0.8-0.50.40.20.10.1-0.50.10.9-0.40.4-0.3
Incentive Sensitization - Breakpoint0.10.20.60.5-0.0-0.8-0.30.20.1-0.10.1-0.30.10.8-0.50.3-0.4
Sum of active levers in priming session hrs 5-60.50.51.00.90.5-0.9-0.91.00.60.80.5-0.7-0.30.90.20.40.1
Progressive ratio1.85.310.9-2.8-1.43.32.8-1.9-2.3-2.0-2.62.51.9-2.7-0.8-2.6-1.1
Food seeking constrained by brief footshock0.30.30.8-0.3-0.90.10.4-0.4-0.8-0.7-0.70.50.90.1-0.9-0.6-0.1
Seeking ratio, punishment vs. effort1.43.26.02.21.0-2.5-2.21.81.61.41.7-2.0-1.12.40.42.01.1
Retroperitoneal fat weight0.10.62.1-0.7-0.50.50.9-1.4-0.4-0.90.10.7-0.2-1.20.1-0.6-0.7
Reaction time number correct0.72.64.4-2.1-1.61.81.9-1.6-1.6-2.1-1.71.81.7-1.3-1.2-0.80.4
Reaction time mean minus median0.52.94.51.91.6-1.9-2.11.81.92.11.9-1.8-1.71.71.10.0-1.2
Reaction time mean minus median AUC0.53.66.22.31.5-2.5-2.41.82.02.32.3-2.0-1.82.11.10.4-1.0
Reaction time num false alarms0.30.51.20.91.1-0.4-0.61.10.81.10.4-0.5-0.50.40.70.50.2
Reaction time num false alarms AUC0.20.41.80.81.2-0.1-0.51.30.70.80.1-0.4-0.30.40.60.40.2
Reaction time trials correct on left0.72.64.4-2.1-1.61.81.9-1.6-1.6-2.1-1.71.81.7-1.3-1.2-0.80.4
Reaction time trials on left0.72.44.1-2.0-1.61.71.8-1.5-1.6-2.0-1.61.71.7-1.2-1.2-0.80.4
Reaction time mean2.04.47.62.42.1-2.2-2.31.62.42.62.7-2.3-2.61.42.11.2-0.0
Reaction time mean AUC1.64.06.92.32.0-2.2-2.21.52.22.42.6-2.1-2.41.31.91.0-0.3
Median of all reaction times2.03.25.91.91.8-1.8-1.81.22.02.12.4-1.9-2.30.92.01.30.3
Reaction time omissions1.52.54.01.91.8-1.8-1.61.31.91.52.0-1.5-2.01.01.50.7-0.8
Reaction time false alarm rate1.72.35.12.02.0-1.2-1.62.31.62.01.1-1.4-1.21.31.31.00.1
Reaction time premature initiation rate0.10.21.6-0.1-0.00.20.1-0.3-0.1-0.10.1-0.2-0.2-0.40.30.11.3
Reaction time premature initiations0.41.22.1-1.5-1.01.41.2-1.2-1.1-1.3-1.00.90.8-1.2-0.4-0.31.4
Std. dev. reaction times1.34.37.22.42.2-2.1-2.52.42.32.72.2-2.2-2.02.01.60.6-0.6
Reaction time trials completed0.72.44.1-2.0-1.61.71.8-1.5-1.6-2.0-1.61.71.7-1.2-1.2-0.80.4
Reaction time trials AUC0.72.34.0-2.0-1.51.71.8-1.6-1.5-2.0-1.51.71.6-1.3-1.1-0.80.4
Run reversals in cocaine runway, females0.50.61.3-1.2-1.10.60.7-1.0-0.8-0.6-0.40.70.6-0.8-0.7-0.8-0.3
Run reversals in cocaine runway, males1.11.21.91.21.0-1.0-1.41.11.01.21.0-1.3-0.91.00.61.21.3
Latency to leave start box in cocaine runway1.31.83.11.41.4-1.1-1.21.01.61.21.7-1.4-1.80.81.41.41.3
Latency to leave start box in cocaine runway, F0.91.12.11.11.0-1.1-1.00.71.40.91.5-1.1-1.50.51.01.1-0.1
Latency to leave start box in cocaine runway, M0.70.74.50.60.9-0.1-0.30.30.60.40.7-0.6-0.80.30.90.72.1
Std. dev. time between licks in bursts3.15.89.52.63.1-1.5-2.32.82.72.62.3-2.4-2.51.52.52.42.2
Total sessions with >9 infusions0.20.31.1-0.2-0.8-0.1-0.30.2-0.50.2-0.5-0.00.70.4-0.80.1-1.1
Short access day 1 total inactive lever presses0.61.11.71.20.9-1.0-1.31.21.21.01.3-1.1-1.00.90.91.20.3
Short access day 10 total inactive lever presses0.10.51.00.81.0-0.8-0.30.21.00.20.7-0.3-0.9-0.40.80.2-1.0
Short access day 1 total infusions0.30.51.20.7-0.1-0.9-1.10.70.41.10.5-0.9-0.21.0-0.01.10.0
Short access day 10 total infusions0.20.32.50.0-0.8-0.5-0.2-0.3-0.30.1-0.10.10.40.3-0.7-0.1-1.6
Short access total infusions0.20.21.00.3-0.6-0.7-0.60.2-0.00.60.2-0.40.20.7-0.40.3-1.0
Short access day 1 locomotion0.40.71.20.70.5-0.7-1.00.60.90.90.8-1.1-0.90.60.31.1-1.0
Short access day 10 total locomotion0.10.51.70.11.10.90.10.90.6-0.0-0.1-0.0-0.5-0.91.30.50.6
Short access total locomotion0.20.30.90.30.70.1-0.40.60.70.40.5-0.5-0.7-0.30.90.8-0.4
One hour access (0.3 mA shock)0.40.51.70.90.2-1.3-0.90.30.50.60.6-0.7-0.61.0-0.30.4-0.5
Compulsive drug intake2.43.57.01.92.5-1.5-1.41.22.41.72.1-1.8-2.60.32.21.81.5
One hour access (shock baseline)0.41.23.0-0.8-1.70.10.4-0.8-1.4-0.8-1.00.81.40.5-1.7-1.1-1.2
Social response proportion0.30.31.50.10.90.4-0.20.60.60.60.5-0.4-0.5-0.41.20.60.3
Social responses0.20.20.6-0.40.70.80.10.60.20.1-0.20.0-0.0-0.40.6-0.5-0.7
Social time2.23.47.21.82.7-1.2-1.61.92.51.81.8-1.7-2.50.72.21.6-0.1
Soleus weight2.88.417.42.94.0-1.3-2.32.93.53.13.1-2.4-3.40.34.22.41.9
Bone: stiffness0.61.12.6-1.1-0.71.31.4-1.4-0.8-1.4-0.81.20.4-1.6-0.2-0.6-0.2
Tibialis anterior weight0.41.42.4-1.6-1.30.91.4-1.4-1.4-1.6-1.21.10.9-1.2-1.1-0.8-0.6
Time to tail flick, vehicle, before self-admin0.40.52.9-0.60.10.50.7-0.70.1-0.6-0.10.7-0.3-0.90.0-0.6-1.7
Time to tail flick, vehicle, after self-admin0.20.50.80.70.6-0.7-0.90.90.80.80.7-0.7-0.60.70.40.6-0.4
Time to tail flick, test, before self-admin0.50.61.4-0.9-0.60.70.4-0.2-0.7-0.6-1.10.80.8-0.2-1.1-1.2-0.3
Time to tail flick, test, after self-admin0.50.52.40.5-0.1-1.1-0.90.60.20.40.2-0.60.01.6-0.90.30.7
Delta time to tail flick, vehicle, before/after SA0.50.52.00.7-0.4-1.2-1.00.50.00.60.4-0.80.11.4-0.60.60.4
Delta time to tail flick, test, before/after SA0.10.20.80.4-0.0-0.9-0.2-0.30.30.10.7-0.3-0.50.40.00.4-0.0
Tibia length0.61.76.20.72.30.8-0.31.31.40.90.8-0.6-1.5-1.02.51.31.1
Ambulatory time before self-admin0.00.10.50.20.3-0.1-0.1-0.10.50.30.5-0.4-0.7-0.40.40.3-0.2
Ambulatory time after self-admin0.10.10.8-0.30.40.90.40.3-0.1-0.1-0.60.20.2-0.40.3-0.10.2
Bone: tissue strength0.10.10.30.0-0.2-0.20.3-0.4-0.0-0.30.20.2-0.1-0.50.3-0.5-0.4
Total heroin consumption0.10.10.30.20.5-0.1-0.20.40.40.20.1-0.2-0.20.20.30.0-0.3
Bone: trabecular number0.30.52.10.1-1.2-1.5-0.1-1.0-0.2-0.00.2-0.10.10.5-1.30.1-0.9
Bone: trabecular spacing0.30.52.6-0.40.81.60.40.7-0.0-0.1-0.40.40.3-0.71.1-0.50.1
Bone: trabecular thickness0.20.31.30.0-0.9-0.90.2-1.2-0.4-0.30.20.1-0.1-0.0-0.90.1-0.1
Bone: trabecular tissue density0.20.31.30.2-0.00.3-0.51.0-0.20.1-0.5-0.30.61.0-0.50.41.1
Water consumed over 24 hours0.20.40.70.60.9-0.2-0.50.60.70.50.6-0.6-0.70.20.80.60.6
Number of responses in last shaping day1.72.24.61.61.6-0.6-1.42.01.21.90.9-1.4-1.01.11.41.72.1