RGD1562465

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr7_61334_64687	0.02	0.02	5.6e-03	0.01	0	0	0	4.3e-02	1.0e-01	1.0e-01	1.1e-01
2	PL	gene expression	RGD1562465	0.05	0.04	8.8e-06	0.05	0.04	0.04	0.04	8.2e-06	2.3e-05	6.8e-05	1.0e-05
3	Liver	gene expression	RGD1562465	0.27	0.18	0.0e+00	0.18	0.18	0.19	0.19	1.5e-19	1.1e-19	3.3e-20	3.6e-20
4	NAcc	gene expression	RGD1562465	0.07	0.05	9.3e-10	0.07	0.08	0.08	0.07	6.9e-09	1.1e-09	2.8e-09	8.9e-09
5	LHb	gene expression	RGD1562465	0.11	0.05	1.1e-03	0.12	0.1	0.11	0.13	1.1e-03	2.6e-03	1.3e-03	6.5e-04
6	Adipose	gene expression	RGD1562465	0.22	0.11	0.0e+00	0.2	0.21	0.21	0.21	1.4e-21	8.3e-23	1.1e-22	1.1e-22
7	Brain	gene expression	RGD1562465	0.12	0.06	5.4e-13	0.12	0.13	0.13	0.13	4.7e-11	2.5e-12	3.8e-12	5.4e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	1.0	1.8	3.9	-1.1	0.9	1.0	-1.2	-1.1	-1.7	-2.0
Area under the delay curve	0.1	0.1	0.2	-0.1	0.5	0.2	-0.2	-0.2	-0.3	-0.3
BMI with tail	7.1	22.9	28.3	5.1	-5.3	-4.8	4.9	5.1	4.3	3.7
BMI without tail	1.5	3.1	3.9	1.6	-1.7	-2.0	1.8	1.9	1.7	1.6
Body weight	0.9	3.9	4.6	1.9	-2.1	-2.1	2.1	2.1	1.8	1.6
Weight adjusted by age	0.1	0.2	0.3	0.3	0.1	-0.4	0.4	0.4	0.5	0.6
Bone surface	2.7	4.8	9.5	-1.8	1.6	1.9	-2.0	-2.0	-2.7	-3.1
Bone volume	2.5	4.3	9.0	-1.7	1.5	1.7	-1.8	-1.8	-2.6	-3.0
Breakpoint value in progressive ratio session	1.3	1.5	2.4	-1.5	1.6	1.2	-1.2	-1.1	-1.0	-0.8
Number of licking bursts	4.9	5.8	6.7	2.6	-2.4	-2.3	2.4	2.4	2.4	2.3
Context. condit. distance diff. score	0.2	0.3	0.4	0.4	-0.5	-0.6	0.5	0.5	0.5	0.5
Locomotion velocity, session 1	0.5	0.5	1.1	-0.7	0.8	0.4	-0.6	-0.4	-0.9	-1.1
Locomotion distance, session 1	1.1	1.4	2.5	-1.0	0.9	1.1	-1.1	-1.2	-1.4	-1.6
Locomotion velocity, session 2	3.6	4.2	5.2	-2.1	2.0	1.8	-1.9	-2.0	-2.2	-2.3
Locomotion distance, session 2	4.7	6.6	7.4	-2.4	2.3	2.6	-2.5	-2.7	-2.7	-2.7
Locomotion velocity, session 3	4.5	5.2	6.6	-2.5	2.6	2.4	-2.3	-2.4	-2.0	-1.7
Locomotion distance, session 3	0.1	0.1	0.1	-0.3	0.2	0.3	-0.2	-0.3	-0.1	-0.1
Stereotopy head waving bouts, day 3	5.4	6.3	7.0	-2.5	2.6	2.6	-2.6	-2.5	-2.4	-2.2
Stereotopy head waving duration, day 3	3.4	4.1	4.6	-2.1	2.1	2.1	-2.1	-2.0	-1.9	-1.8
Locomotion velocity, session 7	0.2	0.2	0.3	-0.4	0.2	0.5	-0.4	-0.5	-0.5	-0.6
Locomotion distance, session 7	0.4	0.5	0.8	0.6	-0.9	-0.6	0.7	0.5	0.8	0.9
Stereotopy head waving bouts, day 7	1.9	2.1	2.5	-1.5	1.3	1.3	-1.5	-1.4	-1.5	-1.6
Stereotopy head waving duration, day 7	2.0	2.4	3.1	-1.6	1.6	1.4	-1.6	-1.4	-1.7	-1.8
Locomotion velocity, session 8	3.8	4.5	5.5	-2.1	2.1	2.0	-2.0	-2.0	-2.3	-2.3
Locomotion distance, session 8	0.6	0.9	1.1	-0.9	0.8	1.0	-0.9	-1.0	-1.0	-0.9
Degree of sensitization distance	0.6	0.6	0.9	0.8	-1.0	-0.8	0.8	0.7	0.6	0.6
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.4	0.2	0.1	-0.3	-0.2	-0.4	-0.6
Conditioned locomotion	2.1	2.5	3.2	1.4	-1.5	-1.5	1.6	1.5	1.7	1.8
Cocaine response after cond. corrected	4.1	4.6	5.5	2.0	-1.9	-2.3	2.1	2.1	2.2	2.2
Cocaine response after cond. not corrected	4.4	4.9	5.7	2.1	-2.0	-2.4	2.2	2.2	2.3	2.3
Cocaine response before conditioning	0.7	0.8	0.9	-0.9	0.8	1.0	-0.9	-0.9	-0.9	-0.9
Saline control response	0.4	0.5	0.6	0.4	-0.6	-0.8	0.7	0.8	0.7	0.7
Bone: connectivity density	0.7	1.0	2.3	-0.8	0.7	0.8	-0.9	-0.8	-1.3	-1.5
Bone: cortical apparent density	1.2	1.5	2.1	1.3	-1.0	-1.4	1.3	1.5	1.1	1.0
Bone: cortical area	0.1	0.2	0.4	0.6	-0.6	-0.4	0.4	0.5	-0.1	-0.4
Bone: cortical porosity	0.2	0.2	0.3	-0.4	0.0	0.5	-0.3	-0.4	-0.5	-0.6
Bone: cortical porosity	0.1	0.1	0.4	-0.1	-0.1	0.3	-0.1	-0.2	-0.5	-0.6
Bone: cortical thickness	0.7	1.2	1.9	1.3	-1.3	-1.1	1.2	1.4	0.7	0.5
Bone: cortical thickness	1.0	1.2	1.4	1.1	-1.1	-0.9	1.2	1.2	1.1	1.0
Bone: cortical tissue density	0.8	1.1	1.6	1.1	-0.7	-1.2	1.2	1.3	0.9	0.9
Condit. Reinf. active minus inactive responses	1.9	2.1	2.7	-1.5	1.4	1.6	-1.5	-1.6	-1.3	-1.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.5	0.1	0.4	-0.3	-0.4	-0.1	0.0
Condit. Reinf. active responses	3.5	4.2	4.7	-2.0	2.0	2.2	-2.1	-2.1	-2.0	-2.0
Condit. Reinf. inactive responses	2.3	2.7	3.3	-1.4	1.6	1.6	-1.7	-1.7	-1.8	-1.8
Incentive salience index mean	2.1	2.5	2.8	-1.5	1.5	1.7	-1.6	-1.7	-1.6	-1.6
Condit. Reinf. lever presses	1.7	2.3	3.5	-1.2	1.4	1.4	-1.4	-1.5	-1.7	-1.9
Condit. Reinf. active minus inactive responses	0.6	0.8	1.1	-1.1	1.1	0.9	-0.9	-1.0	-0.6	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.5	-0.0	0.2	-0.2	0.1	-0.1	0.5	0.7
Condit. Reinf. active responses	0.8	1.1	1.4	-1.1	1.0	1.2	-1.1	-1.1	-0.9	-0.8
Condit. Reinf. inactive responses	0.5	0.7	0.9	-0.6	0.6	1.0	-0.8	-0.8	-0.9	-0.9
Condit. Reinf. lever presses	1.3	1.8	2.6	-1.5	1.4	1.6	-1.4	-1.5	-1.0	-0.7
Condit. Reinf. lever reinforcers received	0.4	0.6	0.8	-0.8	0.8	0.9	-0.8	-0.9	-0.6	-0.4
Conditioned reinforcement - actives	0.1	0.1	0.3	-0.0	0.2	0.2	-0.3	-0.5	-0.4	-0.5
Conditioned reinforcement - inactives	2.0	2.3	2.8	1.3	-1.2	-1.7	1.6	1.5	1.6	1.6
Conditioned locomotion	1.8	2.2	3.1	-1.4	1.3	1.7	-1.5	-1.8	-1.4	-1.3
Patch foraging indifference point 0 sec	2.7	4.3	6.0	2.4	-2.5	-2.0	2.2	2.1	1.7	1.4
Patch foraging indifference point AUC	0.3	0.4	0.6	-0.7	0.6	0.6	-0.7	-0.8	-0.5	-0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.4	0.4	-0.3	-0.1	0.3	0.3	-0.3	-0.6
Delay disc. indifference point, 16s delay	0.3	0.3	0.7	-0.5	0.8	0.5	-0.5	-0.6	-0.5	-0.5
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	0.1	-0.0	0.0	-0.0	0.0	-0.2	-0.3
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.5	-0.5	-0.3	0.4	0.3	0.3	0.2
Delay disc. indifference point, 4s delay	0.9	1.0	1.4	-0.9	0.8	1.0	-1.0	-1.0	-1.1	-1.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	0.5	0.0	-0.5	0.5	0.4	0.5	0.6
Indifference point function ln k	0.1	0.2	0.3	0.4	-0.4	-0.4	0.5	0.5	0.4	0.3
Indifference point function log k	0.1	0.2	0.3	0.4	-0.4	-0.4	0.5	0.5	0.4	0.3
Patch foraging total patch changes 0 sec	2.8	4.5	6.3	2.5	-2.5	-2.0	2.2	2.1	1.8	1.5
Patch foraging total patch changes 12 sec	2.6	3.4	4.1	2.0	-2.0	-1.7	1.9	1.7	1.8	1.7
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	0.3	-0.2	-0.2	0.2	0.1	0.2	0.1
Patch foraging total patch changes 24 sec	0.2	0.3	0.6	0.7	-0.6	-0.5	0.5	0.4	0.4	0.3
Patch foraging total patch changes 6 sec	1.7	2.5	3.5	1.8	-1.9	-1.5	1.7	1.6	1.4	1.2
Patch foraging time to switch 0 sec	0.0	0.0	0.1	0.1	-0.1	-0.2	0.1	0.1	-0.2	-0.3
Patch foraging water rate 0 sec	1.0	1.6	1.8	1.2	-1.1	-1.1	1.3	1.3	1.3	1.3
Patch foraging water rate 12 sec	1.5	2.3	2.6	1.6	-1.4	-1.5	1.5	1.3	1.6	1.6
Patch foraging water rate 18 sec	0.7	1.0	2.5	0.6	-0.6	-0.7	0.9	0.7	1.3	1.6
Patch foraging water rate 24 sec	3.8	5.3	7.8	2.2	-1.9	-2.1	2.3	2.1	2.6	2.8
Patch foraging water rate 6 sec	0.1	0.1	0.4	-0.2	0.1	0.0	0.1	0.0	0.4	0.7
Seeking ratio, delayed vs. immediate footshock	1.8	2.0	2.3	-1.3	1.3	1.5	-1.4	-1.5	-1.5	-1.5
Distance traveled before self-admin	0.9	0.9	1.8	-0.8	0.6	1.3	-1.0	-1.2	-0.9	-0.9
Distance traveled after self-admin	0.2	0.2	0.4	-0.3	0.3	0.7	-0.5	-0.6	-0.5	-0.5
Extensor digitorum longus weight	5.5	21.5	25.3	4.3	-4.5	-5.0	4.9	4.9	4.5	4.2
Bone: elastic displacement	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.1	0.0	-0.1	-0.1
Bone: elastic work	0.2	0.3	0.6	0.6	-0.8	-0.5	0.5	0.6	0.2	0.0
Bone: endosteal estimation	0.3	0.6	1.0	0.9	-1.0	-1.0	0.7	0.6	0.4	0.2
Bone: endosteal perimeter	0.5	1.0	1.7	-0.7	0.6	1.0	-1.0	-1.0	-1.2	-1.3
Epididymis fat weight	0.0	0.0	0.1	-0.3	-0.1	0.3	-0.1	-0.2	0.0	0.1
Delta time in closed arm before/after self-admin	3.7	3.6	5.2	1.8	-1.7	-1.7	1.8	1.7	2.2	2.3
Delta time in open arm before/after self-admin	0.5	0.4	1.1	0.6	-1.1	-0.7	0.7	0.6	0.4	0.3
Diff in mean of infusions in LGA sessions	1.3	1.5	2.0	-1.4	1.2	1.3	-1.3	-1.3	-1.0	-0.9
Delay discount exponential model param	0.1	0.1	0.2	0.1	-0.4	-0.2	0.2	0.2	0.3	0.3
Extinction: sum of active levers before priming	0.9	0.9	1.8	-1.3	0.9	1.2	-1.1	-1.1	-0.6	-0.2
Active lever presses in extinction session 6	1.3	1.2	1.7	-1.2	0.8	1.3	-1.2	-1.2	-1.1	-1.0
Bone: final force	1.0	1.6	2.7	1.6	-1.6	-1.4	1.3	1.2	0.8	0.4
Bone: final moment	0.9	1.5	2.7	1.5	-1.6	-1.3	1.3	1.2	0.7	0.4
Food consumed during 24 hour testing period	0.5	0.6	1.1	0.9	-1.1	-0.6	0.7	0.7	0.7	0.6
Glucose	1.6	2.4	2.8	1.6	-1.7	-1.6	1.6	1.6	1.4	1.2
Heart weight	0.1	0.2	0.4	0.1	-0.2	-0.6	0.4	0.6	0.5	0.5
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.0	-0.2	-0.0	0.1	0.1	0.2	0.2
Intermittent access intake day 1-15 change	0.0	0.0	0.1	-0.0	0.3	0.2	-0.2	-0.4	-0.0	0.0
Intermittent access intake escalation	0.3	0.3	0.8	0.5	-0.3	-0.4	0.4	0.2	0.8	0.9
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.2	0.2	0.0	-0.1	-0.2	0.3	0.4
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.9	0.3	-0.5	-0.6	0.5	0.5	0.8	1.0
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.6	-0.3	0.8	0.6	-0.4	-0.5	-0.1	0.0
Intermitt. access escalation Index	0.9	0.8	1.3	-1.1	0.7	0.6	-0.7	-0.7	-1.1	-1.2
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.3	-0.4	-0.4	0.5	0.4	0.2	0.1
Intermittent access day 15 total infusions	0.3	0.3	0.5	0.7	-0.5	-0.5	0.6	0.4	0.6	0.6
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	0.3	-0.1	-0.2	0.3	0.1	0.0	-0.1
Intermittent access total infusions	0.3	0.4	0.5	0.7	-0.6	-0.6	0.7	0.5	0.6	0.5
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.2	-0.0	-0.1	0.1	0.1	0.1	0.1
Intermittent access day 15 total locomotion	0.2	0.2	0.7	-0.2	0.8	0.3	-0.4	-0.3	-0.3	-0.2
Intermittent access total locomotion	0.3	0.3	0.6	-0.5	0.8	0.5	-0.5	-0.5	-0.5	-0.5
Intermittent access standard deviation	0.0	0.0	0.1	0.1	0.0	0.1	0.0	-0.1	0.2	0.3
Left kidney weight	0.1	0.4	0.9	-0.8	0.5	-0.0	-0.5	-0.4	-0.8	-1.0
Right kidney weight	0.5	1.3	2.0	-1.4	1.2	0.9	-1.1	-1.2	-1.1	-1.1
Cocaine induced anxiety	2.6	3.1	3.5	-1.5	1.6	1.8	-1.8	-1.8	-1.9	-1.9
Post-drug Anxiety	1.7	1.9	3.1	-1.0	1.1	1.3	-1.3	-1.2	-1.6	-1.8
Baseline Anxiety	0.1	0.1	0.1	0.0	-0.2	-0.3	0.2	0.3	0.3	0.4
Tail length	3.6	11.0	14.7	-3.8	3.8	3.3	-3.4	-3.7	-2.7	-2.2
Length with tail	1.9	6.9	8.5	-2.9	2.9	2.6	-2.6	-2.8	-2.4	-2.1
Length without tail	0.0	0.1	0.3	0.1	0.0	0.1	-0.1	-0.0	-0.4	-0.5
Times rat made contact with spout	1.4	1.6	1.8	1.2	-1.4	-1.1	1.3	1.1	1.3	1.3
Lifetime Intake	0.5	0.6	0.8	0.9	-0.8	-0.8	0.9	0.7	0.6	0.4
Liver weight, left	2.1	3.4	3.9	1.8	-2.0	-1.7	1.9	1.9	1.8	1.7
Liver weight, right	0.6	1.1	2.1	0.8	-0.8	-1.4	1.0	1.2	0.9	0.8
Locomotor activity	5.5	8.7	10.7	-3.3	3.1	3.0	-2.9	-2.9	-2.8	-2.6
Locomotor testing distance	2.0	3.4	4.4	-2.1	1.9	1.9	-1.8	-1.8	-1.8	-1.7
Locomotor testing rearing	0.0	0.0	0.1	-0.3	0.1	0.0	0.1	0.1	0.1	0.2
Locomotion in novel chamber	0.4	0.5	0.5	0.7	-0.7	-0.7	0.7	0.7	0.6	0.6
Locomotion in novel chamber post-restriction	2.4	2.9	3.8	-1.6	1.6	2.0	-1.8	-1.9	-1.5	-1.4
Fecal boli incidents, locomotor time 1	1.5	1.6	2.0	1.1	-1.3	-1.4	1.2	1.1	1.4	1.4
Change in fecal boli incidents, locomotor task	1.9	1.8	2.4	-1.0	1.5	1.4	-1.3	-1.2	-1.5	-1.6
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.5	-0.5	-0.3	0.3	0.3	-0.0	-0.2
Bouts of movement, locomotor time 1	0.3	0.3	0.6	-0.8	0.7	0.5	-0.5	-0.4	-0.5	-0.3
Total resting periods, locomotor time 1	1.0	1.1	1.6	-1.2	1.3	0.9	-1.0	-0.9	-0.9	-0.8
Rest time, locomotor task time 1	0.7	0.8	1.1	-0.8	1.1	0.9	-0.9	-0.8	-0.9	-0.8
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.5	-0.5	-0.3	0.3	0.3	0.0	-0.2
Vertical activity count, locomotor time 1	1.2	1.3	1.7	1.3	-1.0	-1.1	1.2	1.1	1.1	1.0
Time >=10cm from walls, locomotor time 2	1.9	2.0	3.2	1.3	-1.8	-1.4	1.4	1.3	1.4	1.3
Bouts of movement, locomotor time 2	1.0	1.1	1.5	-1.0	0.9	0.9	-0.9	-1.0	-1.2	-1.2
Total resting periods, locomotor time 2	1.1	1.2	1.8	-1.0	1.0	0.9	-1.0	-1.0	-1.3	-1.3
Rest time, locomotor task time 2	0.5	0.5	0.8	-0.7	0.8	0.6	-0.7	-0.5	-0.8	-0.9
Distance moved, locomotor task time 2	0.5	0.5	0.9	0.7	-1.0	-0.6	0.7	0.5	0.8	0.9
Vertical activity count, locomotor time 2	2.6	2.8	3.4	1.6	-1.8	-1.6	1.7	1.5	1.7	1.8
Light reinforcement 1	3.5	6.4	7.6	-2.5	2.5	2.7	-2.6	-2.7	-2.4	-2.2
Light reinforcement 2	0.8	1.0	1.5	-1.0	0.8	1.2	-1.1	-1.0	-0.9	-0.9
Bone: marrow area	0.2	0.5	0.9	0.9	-1.0	-0.9	0.7	0.5	0.4	0.2
Bone: maximum diameter	1.0	1.9	3.0	-1.2	1.2	1.2	-1.3	-1.3	-1.6	-1.7
Bone: maximum force	1.3	2.2	3.5	1.8	-1.9	-1.6	1.5	1.5	1.0	0.6
Bone: maximum moment	1.2	2.0	3.4	1.7	-1.9	-1.6	1.5	1.4	0.9	0.6
Mean time between licks in bursts	0.2	0.3	0.6	-0.5	0.4	0.8	-0.6	-0.6	-0.3	-0.1
Mean num. licks in bursts	1.3	1.6	2.1	-1.4	1.2	1.3	-1.2	-1.4	-1.2	-1.1
Cd content in liver	0.6	0.6	1.2	0.8	-1.1	-0.6	0.8	0.7	0.7	0.6
Co content in liver	0.5	0.6	1.3	-1.0	1.1	0.8	-0.8	-0.8	-0.6	-0.3
Cu content in liver	0.2	0.3	0.5	0.7	-0.7	-0.6	0.6	0.6	0.0	-0.3
Fe content in liver	0.9	1.1	1.3	1.0	-1.1	-1.0	1.1	0.9	1.1	1.1
K content in liver	1.1	1.1	1.4	-1.1	0.8	1.0	-1.0	-1.1	-1.1	-1.2
Mg content in liver	1.0	1.0	1.6	-0.9	0.7	1.0	-1.0	-1.0	-1.1	-1.2
Mn content in liver	2.2	2.5	4.8	-1.2	1.0	1.4	-1.5	-1.4	-1.9	-2.2
Na content in liver	0.0	0.0	0.1	-0.2	-0.0	0.1	-0.1	-0.1	-0.3	-0.4
Rb content in liver	0.1	0.1	0.3	0.5	-0.5	-0.3	0.3	0.4	-0.1	-0.4
Se content in liver	0.1	0.1	0.3	-0.5	0.2	0.3	-0.3	-0.3	-0.4	-0.4
Sr content in liver	0.2	0.2	0.6	0.0	-0.0	-0.3	0.3	0.2	0.6	0.8
Zn content in liver	0.4	0.4	1.1	-1.0	0.9	0.6	-0.5	-0.7	-0.0	0.4
Bone: minimum diameter	0.0	0.1	0.3	0.0	-0.2	-0.1	0.1	0.1	-0.3	-0.5
Time in familiar zone, hab. session 1	3.1	2.9	4.3	-1.8	1.5	2.1	-1.8	-2.1	-1.4	-1.1
Time in novel zone, hab. session 1	1.3	1.3	2.1	1.3	-1.1	-1.4	1.1	1.5	0.7	0.3
Total zone transitions, hab. session 1	1.3	1.8	2.7	-1.3	1.1	1.4	-1.3	-1.2	-1.5	-1.6
Total locomotion distance, hab. session 1	4.0	5.6	7.4	-2.2	2.1	2.4	-2.3	-2.3	-2.6	-2.7
Locomotion velocity, hab. session 1	3.7	5.2	6.1	-2.2	2.2	2.3	-2.2	-2.2	-2.4	-2.5
Time in familiar zone, hab. session 2	2.4	2.5	3.4	-1.8	1.7	1.8	-1.6	-1.7	-1.2	-0.8
Time in novel zone, hab. session 2	2.4	2.4	3.4	1.8	-1.7	-1.8	1.6	1.8	1.1	0.7
Total zone transitions, hab. session 2	0.2	0.2	1.0	-0.2	0.2	0.3	-0.2	-0.2	-0.7	-1.0
Total locomotion distance, hab. session 2	1.3	1.8	2.3	-1.2	1.4	1.3	-1.2	-1.2	-1.5	-1.5
Locomotion velocity, hab. session 2	1.7	2.4	3.3	-1.4	1.5	1.4	-1.4	-1.4	-1.7	-1.8
Novel to familiar place preference ratio	0.6	0.6	1.2	1.1	-1.0	-0.7	0.9	0.9	0.4	0.0
Novelty place preference	0.3	0.3	0.7	0.8	-0.8	-0.5	0.6	0.7	0.2	-0.1
Time in novel zone, NPP test	0.6	0.7	1.1	1.1	-1.0	-0.7	0.9	0.9	0.4	0.1
Total zone transitions, NPP test	0.0	0.0	0.1	0.1	-0.2	0.1	0.1	0.0	-0.2	-0.4
Total locomotion distance, NPP test	0.3	0.4	1.0	-0.4	0.6	0.5	-0.5	-0.5	-0.8	-1.0
Locomotion velocity, NPP test	0.6	0.8	1.3	-0.7	0.9	0.8	-0.8	-0.8	-1.1	-1.2
Intraocular pressure	0.1	0.1	0.2	-0.2	0.2	0.3	-0.1	-0.4	0.2	0.4
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.0	0.2	-0.3	0.1	0.1	-0.0	-0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	-0.0	0.2	-0.1	-0.1	-0.0	-0.3	-0.4
Parametrial fat weight	0.0	0.0	0.1	0.1	-0.3	-0.0	0.1	0.2	0.2	0.3
Pavlov. Cond. lever latency	0.6	0.8	1.4	0.6	-1.0	-0.8	0.8	0.7	1.1	1.2
Pavlov. Cond. magazine entry latency	1.0	1.4	1.9	-1.2	1.4	1.2	-1.2	-1.2	-1.0	-0.8
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.4	-0.3	-0.2	0.3	0.2	0.2	0.1
Pavlov. Cond. index score	1.0	1.3	1.5	-1.0	1.2	1.1	-1.1	-1.0	-1.2	-1.2
Pavlov. Cond. latency score	1.4	1.7	2.1	-1.2	1.5	1.3	-1.3	-1.1	-1.4	-1.5
Pavlov. Cond. lever contacts	0.8	0.9	1.7	-0.7	1.0	0.8	-0.8	-0.7	-1.2	-1.3
Pavlov. Cond. magazine entry number	0.5	0.6	0.8	0.8	-0.9	-0.8	0.8	0.8	0.7	0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.2	-0.2	-0.1	0.2	0.1	0.5	0.6
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.5	-1.1	1.2	1.2	-1.1	-1.1	-1.2	-1.2
Pavlov. Cond. response bias	0.8	1.0	1.2	-1.1	1.0	1.1	-1.0	-1.1	-0.9	-0.8
Pavlov. Cond. lever latency	1.5	2.1	2.6	1.6	-1.4	-1.6	1.5	1.5	1.3	1.1
Pavlov. Cond. magazine entry latency	2.2	2.5	3.0	-1.7	1.6	1.7	-1.7	-1.6	-1.5	-1.3
Pavlov. Cond. change in total contacts	0.5	0.6	1.0	-0.9	0.7	1.0	-0.8	-1.0	-0.7	-0.5
Pavlov. Cond. index score	1.6	2.1	2.8	-1.6	1.4	1.7	-1.5	-1.5	-1.3	-1.1
Pavlov. Cond. latency score	2.1	2.6	3.4	-1.7	1.5	1.8	-1.7	-1.7	-1.5	-1.3
Pavlov. Cond. lever contacts	0.9	1.2	1.7	-1.2	1.1	1.3	-1.1	-1.2	-0.9	-0.7
Pavlov. Cond. magazine entry number	1.9	2.3	2.9	1.6	-1.5	-1.7	1.6	1.5	1.4	1.3
Pavlov. Cond. intertrial magazine entries	0.8	1.1	1.5	0.8	-0.7	-1.2	1.1	1.1	1.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.3	3.0	-1.7	1.5	1.7	-1.6	-1.6	-1.4	-1.2
Pavlov. Cond. response bias	1.4	1.9	2.5	-1.5	1.5	1.6	-1.4	-1.4	-1.1	-0.9
Time in closed arm before self-admin	0.2	0.2	0.6	-0.3	0.5	0.0	-0.3	-0.2	-0.7	-0.8
Time in closed arm after self-admin	0.2	0.2	0.5	0.7	-0.1	-0.6	0.5	0.6	0.4	0.3
Time in open arm before self-admin	0.1	0.1	0.1	0.3	-0.3	0.2	0.1	0.1	0.3	0.3
Time in open arm after self-admin	1.6	1.8	3.7	1.4	-1.9	-1.1	1.3	1.1	1.3	1.2
Bone: periosteal estimation	0.2	0.4	0.8	0.8	-0.9	-0.8	0.6	0.5	0.0	-0.3
Bone: periosteal perimeter	0.3	0.4	1.3	-0.3	0.2	0.6	-0.5	-0.4	-0.9	-1.1
Bone: post-yield work	0.2	0.2	0.5	0.5	-0.4	-0.7	0.5	0.5	0.4	0.4
Progressive ratio test 1 active lever presses	1.2	1.2	1.7	1.1	-1.1	-1.3	1.2	1.1	1.0	1.0
Progressive ratio test 1 breakpoint	1.1	1.1	1.6	1.0	-1.1	-1.3	1.2	1.0	1.0	0.9
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.0	0.3	-0.1	-0.0	-0.0	-0.1	-0.1
Progressive ratio test 2 active lever presses	0.3	0.3	0.6	0.6	-0.5	-0.8	0.6	0.5	0.5	0.4
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.1	0.1	-0.2	0.0	-0.1	-0.2	-0.3
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.5	-0.1	-0.2	0.3	0.3	0.0	-0.1
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.4	0.4	0.2	-0.3	-0.4	-0.3	-0.3
Incentive Sensitization - Breakpoint	0.3	0.3	0.3	-0.5	0.6	0.4	-0.5	-0.6	-0.5	-0.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	-0.4	-0.3	0.6	-0.4	-0.2	-0.2	-0.2
Progressive ratio	1.3	1.5	1.7	1.2	-1.2	-1.3	1.2	1.2	1.2	1.1
Food seeking constrained by brief footshock	1.3	1.5	2.3	-1.3	1.0	1.5	-1.3	-1.4	-1.1	-1.0
Seeking ratio, punishment vs. effort	1.9	2.4	3.0	-1.6	1.5	1.7	-1.6	-1.6	-1.4	-1.2
Retroperitoneal fat weight	2.1	7.0	8.7	2.5	-2.7	-3.0	2.8	2.8	2.5	2.3
Reaction time number correct	1.9	2.7	3.6	1.9	-1.8	-1.3	1.6	1.3	1.8	1.7
Reaction time mean minus median	2.4	3.1	5.0	-2.0	2.2	1.6	-1.7	-1.7	-1.7	-1.4
Reaction time mean minus median AUC	4.0	5.2	6.9	-2.2	2.6	2.1	-2.2	-2.1	-2.4	-2.3
Reaction time num false alarms	0.6	0.8	0.9	0.9	-0.7	-1.0	0.9	0.9	0.9	0.8
Reaction time num false alarms AUC	0.8	1.1	1.4	0.9	-0.8	-1.2	1.1	1.1	1.1	1.1
Reaction time trials correct on left	1.9	2.7	3.6	1.9	-1.8	-1.3	1.6	1.3	1.8	1.7
Reaction time trials on left	1.7	2.5	3.4	1.8	-1.8	-1.2	1.5	1.2	1.7	1.6
Reaction time mean	2.1	2.9	3.7	-1.9	1.9	1.4	-1.7	-1.4	-1.8	-1.7
Reaction time mean AUC	1.2	1.6	2.1	-1.4	1.4	1.0	-1.2	-1.0	-1.4	-1.4
Median of all reaction times	1.1	1.5	2.0	-1.4	1.2	1.0	-1.2	-0.9	-1.3	-1.3
Reaction time omissions	0.0	0.0	0.1	-0.1	0.2	0.0	-0.1	0.1	-0.2	-0.3
Reaction time false alarm rate	0.0	0.0	0.1	-0.1	0.2	-0.3	0.1	0.3	0.0	0.0
Reaction time premature initiation rate	0.6	0.8	1.7	-1.3	1.2	0.8	-0.9	-0.9	-0.6	-0.3
Reaction time premature initiations	0.1	0.1	0.5	-0.2	0.1	0.1	0.0	-0.2	0.4	0.7
Std. dev. reaction times	1.7	2.3	3.3	-1.7	1.8	1.3	-1.5	-1.3	-1.6	-1.4
Reaction time trials completed	1.7	2.5	3.4	1.8	-1.8	-1.2	1.5	1.2	1.7	1.6
Reaction time trials AUC	2.2	3.1	4.0	2.0	-2.0	-1.4	1.7	1.4	1.9	1.8
Run reversals in cocaine runway, females	2.1	2.0	2.6	-1.3	1.5	1.6	-1.4	-1.3	-1.4	-1.3
Run reversals in cocaine runway, males	2.9	2.8	3.3	-1.8	1.6	1.6	-1.7	-1.7	-1.6	-1.6
Latency to leave start box in cocaine runway	0.5	0.5	1.3	-0.4	0.5	0.5	-0.6	-0.5	-0.9	-1.1
Latency to leave start box in cocaine runway, F	0.7	0.7	2.0	-0.4	0.6	0.6	-0.7	-0.6	-1.2	-1.4
Latency to leave start box in cocaine runway, M	0.2	0.1	0.4	0.2	-0.2	-0.3	0.3	0.4	0.5	0.6
Std. dev. time between licks in bursts	0.8	1.0	1.5	-0.7	0.8	1.1	-1.0	-0.9	-1.1	-1.2
Total sessions with >9 infusions	0.1	0.1	0.5	0.3	-0.0	0.2	-0.0	-0.1	-0.5	-0.7
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.3	0.2	-0.0	0.1	0.2	-0.0	-0.1
Short access day 10 total inactive lever presses	0.3	0.3	0.5	0.1	-0.1	-0.7	0.5	0.6	0.6	0.7
Short access day 1 total infusions	0.1	0.1	0.3	0.4	0.0	-0.2	0.2	0.2	-0.3	-0.6
Short access day 10 total infusions	0.5	0.5	0.8	0.9	-0.7	-0.7	0.9	0.7	0.6	0.5
Short access total infusions	0.3	0.4	0.6	0.7	-0.6	-0.7	0.8	0.6	0.2	-0.0
Short access day 1 locomotion	0.3	0.3	0.5	-0.4	0.7	0.4	-0.5	-0.5	-0.6	-0.7
Short access day 10 total locomotion	0.4	0.5	0.8	-0.9	0.9	0.6	-0.7	-0.7	-0.4	-0.2
Short access total locomotion	0.3	0.3	0.4	-0.6	0.6	0.5	-0.5	-0.5	-0.5	-0.5
One hour access (0.3 mA shock)	0.3	0.4	0.6	0.8	-0.7	-0.7	0.7	0.5	0.5	0.5
Compulsive drug intake	0.1	0.1	0.2	0.3	-0.4	-0.4	0.3	0.3	0.2	0.1
One hour access (shock baseline)	0.5	0.5	0.8	0.9	-0.9	-0.5	0.7	0.5	0.8	0.8
Social response proportion	1.3	1.5	1.7	-1.3	1.3	1.1	-1.2	-1.1	-1.2	-1.2
Social responses	10.5	13.5	15.4	-3.9	3.8	3.7	-3.8	-3.7	-3.5	-3.3
Social time	0.8	1.1	1.7	0.9	-0.8	-1.3	1.1	1.1	1.1	1.0
Soleus weight	4.6	13.5	17.0	3.7	-3.5	-4.1	4.0	4.0	3.4	3.0
Bone: stiffness	2.5	3.9	5.5	2.3	-2.2	-2.1	2.1	2.1	1.5	1.2
Tibialis anterior weight	0.8	2.8	3.5	1.5	-1.8	-1.9	1.9	1.6	1.6	1.4
Time to tail flick, vehicle, before self-admin	3.4	3.4	4.6	-1.7	1.8	1.6	-1.8	-1.7	-2.1	-2.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.4	0.3	0.1	-0.1	-0.1	0.2	0.4
Time to tail flick, test, before self-admin	2.5	2.4	3.3	-1.4	1.8	1.3	-1.5	-1.3	-1.7	-1.7
Time to tail flick, test, after self-admin	0.5	0.5	1.0	-0.5	-0.0	0.7	-0.7	-0.8	-0.9	-1.0
Delta time to tail flick, vehicle, before/after SA	2.5	2.5	3.7	1.3	-1.4	-1.5	1.5	1.5	1.8	1.9
Delta time to tail flick, test, before/after SA	0.2	0.2	0.6	0.2	-0.8	-0.1	0.2	-0.1	0.4	0.5
Tibia length	0.8	2.4	3.5	-1.7	1.9	1.6	-1.6	-1.6	-1.3	-1.0
Ambulatory time before self-admin	0.2	0.2	0.6	-0.4	-0.0	0.8	-0.5	-0.6	-0.4	-0.4
Ambulatory time after self-admin	0.1	0.1	0.1	-0.0	-0.0	0.4	-0.2	-0.3	-0.2	-0.3
Bone: tissue strength	3.3	3.2	4.7	2.1	-2.2	-1.8	1.8	1.7	1.5	1.2
Total heroin consumption	2.4	2.8	4.0	-2.0	1.2	1.8	-1.7	-1.6	-1.6	-1.5
Bone: trabecular number	2.0	3.2	4.3	-1.8	1.5	1.7	-1.7	-1.6	-2.0	-2.1
Bone: trabecular spacing	2.3	3.0	5.3	1.6	-1.4	-1.5	1.6	1.5	2.1	2.3
Bone: trabecular thickness	2.3	2.8	6.4	-1.3	1.1	1.3	-1.4	-1.3	-2.1	-2.5
Bone: trabecular tissue density	6.3	8.9	10.0	3.1	-2.8	-3.2	3.1	3.1	2.9	2.7
Water consumed over 24 hours	0.2	0.2	0.4	0.6	-0.6	-0.5	0.5	0.5	0.1	-0.2
Number of responses in last shaping day	0.8	0.9	1.6	-0.9	1.3	0.9	-0.9	-1.0	-0.8	-0.7