Hub : Genes

RGD1559459

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression RGD1559459 0.1 0.09 1.9e-03 0.07 0.03 0.08 0.07 3.7e-04 3.0e-02 2.8e-04 7.3e-04
2 Liver intron excision ratio chr14_21108751_21110421 0.46 0.16 0.0e+00 0.29 0.29 0.3 0.28 5.7e-32 5.0e-32 3.9e-34 4.3e-31
3 Liver intron excision ratio chr14_21146282_21148449 0.1 0.09 2.7e-06 0.04 0.03 0.03 0 1.9e-05 1.1e-04 1.4e-04 2.3e-01
4 Liver intron excision ratio chr14_21146282_21151091 0.16 0.09 3.2e-14 0.08 0.09 0.09 0.09 4.1e-09 5.6e-10 1.1e-09 3.2e-10
5 Liver intron excision ratio chr14_21148566_21151091 0.09 0.06 1.7e-06 0.03 0.01 0.02 0 1.6e-04 1.2e-02 8.9e-04 3.6e-01
6 PL gene expression RGD1559459 0.13 0.08 2.4e-13 0.13 0.12 0.11 0.13 9.2e-14 1.1e-12 3.7e-12 1.1e-13
7 Liver intron excision ratio chr14_21151859_21153588 0.84 0.07 0.0e+00 0.24 0.22 0.25 0.26 7.3e-27 2.9e-24 1.5e-27 8.7e-29
8 BLA gene expression RGD1559459 0.16 0.09 5.9e-09 0.15 0.14 0.14 0.15 2.9e-08 3.9e-08 8.3e-08 1.7e-08
9 NAcc gene expression RGD1559459 0.34 0.2 0.0e+00 0.16 0.12 0.13 0.15 3.4e-18 1.7e-13 3.8e-15 2.9e-17
10 Liver isoform ratio XM_006250809.3 0.05 0.03 5.5e-05 0.01 0.02 0.02 0.02 1.5e-02 6.0e-03 3.7e-03 6.5e-03
11 Liver isoform ratio XM_003751344.4 0.04 0.03 7.0e-04 -0 0 0.01 -0 5.9e-01 1.2e-01 1.9e-02 6.5e-01
12 Liver gene expression RGD1559459 0.94 0.01 0.0e+00 0.49 0.27 0.55 0.33 2.4e-61 1.1e-29 1.1e-72 2.2e-37

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.20.30.50.10.5-0.60.6-0.6-0.60.60.7-0.60.5-0.6-0.2
Area under the delay curve0.00.00.1-0.20.00.20.20.20.2-0.0-0.2-0.10.3-0.30.1
BMI with tail0.93.07.1-0.01.5-1.32.0-1.4-1.31.81.5-1.92.6-2.7-1.0
BMI without tail0.20.41.5-1.2-0.60.6-0.00.70.6-0.3-0.40.20.7-0.70.6
Body weight0.10.51.90.00.5-0.40.7-0.2-0.30.60.3-0.81.2-1.4-0.3
Weight adjusted by age1.71.92.70.91.5-1.41.5-1.5-1.61.41.6-1.51.1-1.0-1.5
Bone surface0.10.30.70.50.5-0.80.4-0.6-0.60.40.7-0.3-0.0-0.0-0.4
Bone volume0.00.10.2-0.3-0.30.0-0.20.20.2-0.2-0.10.3-0.40.30.4
Breakpoint value in progressive ratio session0.20.20.5-0.3-0.50.5-0.40.60.7-0.5-0.60.5-0.30.30.3
Number of licking bursts0.10.10.50.70.3-0.30.3-0.3-0.20.20.3-0.30.3-0.3-0.1
Context. condit. distance diff. score0.40.53.41.80.3-0.6-0.2-0.5-0.50.20.50.1-0.90.8-0.7
Locomotion velocity, session 10.40.41.3-0.30.5-0.30.7-0.3-0.20.50.3-0.71.1-1.1-0.6
Locomotion distance, session 10.30.41.1-1.1-0.60.4-0.50.50.5-0.6-0.40.5-0.70.60.6
Locomotion velocity, session 20.10.10.9-1.0-0.2-0.0-0.20.10.1-0.2-0.00.2-0.30.20.1
Locomotion distance, session 20.20.31.5-1.2-0.50.3-0.40.50.5-0.5-0.30.4-0.40.40.5
Locomotion velocity, session 30.70.81.1-1.0-1.00.9-0.90.80.9-0.9-0.80.9-0.90.90.7
Locomotion distance, session 30.00.00.1-0.4-0.20.2-0.00.10.1-0.1-0.00.2-0.20.20.3
Stereotopy head waving bouts, day 30.40.51.00.30.7-0.60.8-0.5-0.50.70.6-0.81.0-1.0-0.7
Stereotopy head waving duration, day 30.00.10.1-0.10.2-0.10.2-0.1-0.10.20.1-0.30.3-0.3-0.3
Locomotion velocity, session 72.73.03.9-2.0-1.91.8-1.81.81.8-1.8-1.71.7-1.41.31.5
Locomotion distance, session 71.31.72.0-1.4-1.31.2-1.31.21.3-1.3-1.31.4-1.41.31.0
Stereotopy head waving bouts, day 70.30.30.5-0.20.7-0.60.6-0.6-0.60.60.5-0.60.4-0.3-0.7
Stereotopy head waving duration, day 70.20.20.6-0.80.3-0.20.5-0.2-0.30.40.3-0.50.7-0.7-0.1
Locomotion velocity, session 80.10.10.2-0.20.3-0.40.2-0.4-0.40.20.3-0.2-0.20.2-0.3
Locomotion distance, session 80.30.41.70.3-0.40.0-0.70.10.2-0.6-0.10.7-1.31.2-0.1
Degree of sensitization distance1.01.01.4-0.4-0.90.9-1.11.01.0-1.1-1.11.1-1.21.10.6
Degree of sensitization stereotypy0.00.00.2-0.40.3-0.20.2-0.2-0.20.10.1-0.1-0.00.1-0.2
Conditioned locomotion0.40.51.01.00.7-0.70.6-0.8-0.70.60.8-0.60.5-0.5-0.5
Cocaine response after cond. corrected0.70.71.0-0.2-0.90.9-1.01.00.9-1.0-0.90.9-0.90.80.5
Cocaine response after cond. not corrected0.50.61.00.0-0.70.6-0.90.70.7-0.9-0.70.9-1.00.80.4
Cocaine response before conditioning0.20.30.60.30.5-0.80.5-0.7-0.50.40.6-0.40.2-0.3-0.4
Saline control response0.60.71.0-0.6-0.90.6-0.90.90.9-1.0-0.80.9-0.90.81.0
Bone: connectivity density0.40.61.1-0.10.7-0.90.8-0.9-0.80.91.0-0.80.9-1.0-0.3
Bone: cortical apparent density0.60.82.1-1.4-0.81.2-0.61.01.0-0.6-1.10.50.2-0.21.1
Bone: cortical area0.20.30.5-0.3-0.60.5-0.50.70.7-0.7-0.70.6-0.30.30.5
Bone: cortical porosity2.42.63.31.41.6-1.81.6-1.7-1.81.61.7-1.51.3-1.3-1.7
Bone: cortical porosity3.53.84.41.62.0-2.12.0-2.0-2.02.02.0-1.91.8-1.8-2.0
Bone: cortical thickness0.30.51.00.40.6-0.80.8-0.6-0.60.70.7-0.70.9-1.0-0.5
Bone: cortical thickness0.10.10.30.3-0.2-0.1-0.30.00.0-0.20.00.3-0.60.50.2
Bone: cortical tissue density0.50.71.8-1.3-0.71.2-0.50.90.9-0.5-1.00.40.3-0.31.0
Condit. Reinf. active minus inactive responses0.60.71.60.20.8-0.70.9-0.7-0.70.80.8-0.91.1-1.3-0.8
Condit. Reinf. active-inactive response ratio3.53.84.41.32.0-2.02.1-2.0-2.02.12.1-2.01.9-2.0-1.8
Condit. Reinf. active responses0.10.10.4-0.6-0.30.4-0.20.30.3-0.3-0.20.2-0.0-0.10.2
Condit. Reinf. inactive responses2.73.23.7-1.4-1.81.9-1.91.91.8-1.9-1.81.8-1.81.71.5
Incentive salience index mean0.10.10.3-0.40.2-0.10.3-0.1-0.10.20.2-0.20.4-0.6-0.3
Condit. Reinf. lever presses0.00.00.2-0.4-0.1-0.0-0.00.10.1-0.2-0.10.1-0.10.0-0.1
Condit. Reinf. active minus inactive responses0.30.31.4-1.2-0.60.3-0.30.60.5-0.5-0.40.4-0.30.20.7
Condit. Reinf. active-inactive response ratio0.40.40.7-0.8-0.70.5-0.50.70.7-0.7-0.60.6-0.40.40.8
Condit. Reinf. active responses0.20.31.4-1.2-0.50.2-0.30.50.3-0.5-0.30.3-0.50.30.6
Condit. Reinf. inactive responses0.20.20.5-0.7-0.40.2-0.40.30.2-0.4-0.10.4-0.70.60.4
Condit. Reinf. lever presses0.30.41.1-0.5-0.60.2-0.70.50.3-0.6-0.30.7-1.10.90.6
Condit. Reinf. lever reinforcers received0.20.20.9-1.0-0.50.2-0.40.40.2-0.4-0.20.4-0.60.50.5
Conditioned reinforcement - actives0.40.40.6-0.60.6-0.80.6-0.8-0.60.60.6-0.40.5-0.5-0.7
Conditioned reinforcement - inactives1.11.21.7-0.9-1.01.0-1.21.01.0-1.2-1.21.2-1.31.30.7
Conditioned locomotion0.10.10.3-0.50.2-0.60.3-0.4-0.20.10.3-0.00.1-0.1-0.3
Patch foraging indifference point 0 sec0.40.60.8-0.7-0.80.8-0.80.70.9-0.8-0.70.9-0.80.50.8
Patch foraging indifference point AUC3.74.26.3-1.8-2.12.5-2.22.22.1-2.0-2.22.0-1.71.72.0
Delay disc. indifference point, 0s delay0.10.10.2-0.20.1-0.00.30.1-0.00.20.1-0.30.4-0.40.1
Delay disc. indifference point, 16s delay0.40.41.3-0.40.4-0.11.0-0.1-0.10.50.2-0.71.1-1.1-0.1
Delay disc. indifference point, 2s delay2.62.93.5-1.2-1.71.8-1.91.71.8-1.8-1.81.8-1.71.81.5
Delay disc. indifference point, 24s delay0.30.30.40.60.6-0.40.6-0.6-0.50.50.4-0.50.5-0.5-0.6
Delay disc. indifference point, 4s delay0.80.81.3-1.0-0.81.1-0.71.11.1-0.8-1.10.7-0.40.51.1
Delay disc. indifference point, 8s delay1.21.22.60.51.0-0.81.3-0.9-0.81.11.0-1.21.5-1.6-0.8
Indifference point function ln k1.42.02.71.51.5-1.61.4-1.5-1.51.41.5-1.41.0-1.2-1.3
Indifference point function log k1.42.02.71.51.5-1.61.4-1.5-1.51.41.5-1.41.0-1.2-1.3
Patch foraging total patch changes 0 sec0.40.70.9-0.8-0.90.9-0.80.70.9-0.8-0.70.9-0.80.50.9
Patch foraging total patch changes 12 sec0.91.24.0-2.0-1.11.5-1.10.91.0-0.8-1.00.8-0.50.41.2
Patch foraging total patch changes 18 sec0.30.40.7-0.7-0.70.9-0.70.60.6-0.5-0.70.5-0.50.40.7
Patch foraging total patch changes 24 sec1.11.42.5-1.6-1.21.3-1.21.11.2-1.2-1.11.3-1.00.71.1
Patch foraging total patch changes 6 sec1.92.73.7-1.7-1.71.9-1.61.61.8-1.6-1.81.7-1.41.31.8
Patch foraging time to switch 0 sec3.55.46.82.12.3-2.32.4-2.2-2.22.42.3-2.52.6-2.4-2.1
Patch foraging water rate 0 sec1.93.15.2-2.3-1.71.7-1.71.51.7-1.7-1.71.7-1.81.81.6
Patch foraging water rate 12 sec0.20.40.9-0.8-0.50.1-0.50.30.4-0.6-0.40.8-1.00.90.5
Patch foraging water rate 18 sec1.72.33.8-1.7-1.41.2-1.61.21.3-1.5-1.31.7-2.01.91.4
Patch foraging water rate 24 sec0.81.23.4-1.0-0.80.6-1.20.40.6-1.0-0.71.2-1.81.80.7
Patch foraging water rate 6 sec0.71.12.9-1.7-0.80.9-0.90.71.0-0.9-1.11.0-1.11.20.8
Seeking ratio, delayed vs. immediate footshock1.11.21.7-1.0-1.20.8-1.31.01.1-1.1-0.81.3-1.31.20.9
Distance traveled before self-admin0.80.85.5-2.3-0.80.6-0.60.40.6-0.6-0.40.7-0.60.61.0
Distance traveled after self-admin2.62.95.3-2.1-1.61.2-1.81.11.2-1.6-1.31.7-2.32.31.8
Extensor digitorum longus weight9.939.044.34.66.6-6.46.5-6.4-6.36.66.4-6.76.2-6.1-5.8
Bone: elastic displacement0.80.91.81.31.0-1.20.8-1.1-1.20.91.1-0.70.2-0.2-1.0
Bone: elastic work0.50.61.71.30.8-1.10.7-0.8-0.90.60.9-0.40.1-0.1-0.9
Bone: endosteal estimation1.32.84.3-0.9-1.61.5-1.71.71.6-1.8-1.71.7-2.02.11.3
Bone: endosteal perimeter0.20.51.20.0-0.60.5-0.70.70.6-0.7-0.70.7-1.01.10.3
Epididymis fat weight0.10.32.7-1.60.00.40.30.3-0.00.2-0.1-0.40.7-0.70.2
Delta time in closed arm before/after self-admin1.41.42.10.61.3-0.81.5-1.1-1.11.21.0-1.31.4-1.3-1.3
Delta time in open arm before/after self-admin1.71.72.3-0.9-1.51.2-1.41.31.5-1.3-1.21.4-1.21.01.4
Diff in mean of infusions in LGA sessions0.00.00.1-0.20.2-0.10.1-0.3-0.20.20.2-0.1-0.10.1-0.1
Delay discount exponential model param0.10.10.20.30.1-0.4-0.0-0.3-0.30.10.4-0.1-0.10.1-0.3
Extinction: sum of active levers before priming0.80.83.8-2.0-0.70.6-0.70.40.6-0.7-0.60.8-0.91.00.8
Active lever presses in extinction session 60.70.71.0-0.4-0.90.9-1.00.90.8-0.9-0.90.9-0.90.80.6
Bone: final force0.00.10.10.3-0.20.1-0.30.40.3-0.3-0.30.2-0.20.20.3
Bone: final moment0.00.10.10.3-0.20.1-0.30.40.3-0.3-0.40.2-0.20.20.3
Food consumed during 24 hour testing period2.32.74.7-1.2-1.71.2-1.91.41.4-1.7-1.41.8-2.22.11.4
Glucose1.11.73.2-0.8-1.11.3-1.31.11.1-1.2-1.51.3-1.61.81.3
Heart weight0.60.81.2-0.40.9-0.81.0-1.0-1.11.01.0-1.10.8-0.7-0.6
Delay discount hyperbolic model param0.30.30.50.60.4-0.70.3-0.6-0.70.50.7-0.40.2-0.3-0.5
Intermittent access intake day 1-15 change3.13.110.53.21.8-1.81.5-1.7-1.71.51.5-1.40.8-0.8-2.0
Intermittent access intake escalation2.01.99.03.01.4-1.41.0-1.3-1.31.11.0-0.90.3-0.3-1.7
Intermittent access intake escalation 20.60.65.92.40.3-0.2-0.1-0.2-0.10.10.00.1-0.50.5-0.5
Intermitt. access day 1 inactive lever presses1.01.01.8-0.3-0.91.1-1.20.81.0-1.0-1.01.1-1.31.30.8
Intermitt. access day 15 inactive lever presses1.51.72.80.4-1.11.6-1.60.91.1-1.3-1.31.3-1.71.61.0
Intermitt. access escalation Index1.11.01.5-0.01.1-1.21.2-1.0-1.21.01.0-1.10.9-0.8-0.9
Intermittent access day 1 total infusions0.20.32.8-1.7-0.20.1-0.30.10.0-0.1-0.10.1-0.20.20.3
Intermittent access day 15 total infusions0.10.20.50.60.4-0.40.1-0.4-0.50.20.2-0.1-0.30.3-0.7
Intermittent access terminal intake (last 3 days)0.10.10.70.0-0.10.1-0.4-0.10.0-0.1-0.20.4-0.80.80.1
Intermittent access total infusions0.00.10.4-0.60.0-0.1-0.2-0.1-0.1-0.00.00.1-0.30.30.0
Intermittent access day 1 locomotion0.10.11.4-1.2-0.20.0-0.10.10.0-0.10.00.1-0.10.00.2
Intermittent access day 15 total locomotion0.00.00.1-0.30.1-0.20.1-0.3-0.10.00.20.10.0-0.2-0.3
Intermittent access total locomotion0.10.10.2-0.40.3-0.30.2-0.4-0.30.30.3-0.30.3-0.4-0.2
Intermittent access standard deviation0.20.21.41.20.10.0-0.4-0.0-0.1-0.1-0.10.2-0.70.7-0.2
Left kidney weight0.10.40.8-0.6-0.70.4-0.80.60.5-0.6-0.40.7-0.90.70.5
Right kidney weight0.31.01.3-1.1-1.11.0-1.11.21.1-1.0-1.00.9-0.70.40.8
Cocaine induced anxiety0.10.10.3-0.40.2-0.30.3-0.0-0.20.30.3-0.30.5-0.6-0.1
Post-drug Anxiety0.10.20.50.2-0.40.6-0.20.70.5-0.3-0.60.10.2-0.20.3
Baseline Anxiety0.30.31.81.30.10.1-0.2-0.00.1-0.2-0.40.3-0.70.9-0.0
Tail length0.10.20.4-0.1-0.50.4-0.50.50.4-0.5-0.40.5-0.60.50.4
Length with tail0.41.42.2-0.3-1.21.0-1.41.31.2-1.3-1.41.2-1.51.30.9
Length without tail0.20.30.6-0.4-0.50.5-0.70.50.6-0.5-0.80.5-0.70.70.5
Times rat made contact with spout0.40.40.8-0.6-0.60.5-0.60.90.7-0.6-0.80.6-0.50.50.6
Lifetime Intake0.00.00.4-0.60.1-0.2-0.1-0.1-0.20.10.1-0.1-0.10.2-0.0
Liver weight, left3.25.16.5-2.5-2.42.5-2.22.42.3-2.2-2.42.2-1.71.82.3
Liver weight, right3.45.76.3-2.1-2.52.4-2.52.52.4-2.4-2.52.3-2.22.32.5
Locomotor activity0.10.20.80.0-0.2-0.1-0.4-0.00.1-0.3-0.10.4-0.90.90.2
Locomotor testing distance0.10.20.70.60.2-0.80.1-0.5-0.50.20.60.0-0.70.5-0.5
Locomotor testing rearing0.20.30.70.30.5-0.90.2-0.8-0.70.30.7-0.1-0.40.3-0.5
Locomotion in novel chamber0.10.10.3-0.5-0.30.3-0.10.30.5-0.2-0.50.3-0.00.10.3
Locomotion in novel chamber post-restriction1.21.42.2-0.5-1.41.5-1.11.41.4-1.3-1.41.2-0.70.81.0
Fecal boli incidents, locomotor time 11.21.32.40.51.3-1.41.1-1.6-1.31.31.4-1.20.8-0.8-0.8
Change in fecal boli incidents, locomotor task0.10.10.90.90.3-0.10.4-0.3-0.20.20.1-0.20.10.1-0.2
Time >=10cm from walls, locomotor time 11.01.01.30.61.1-1.11.1-1.1-1.11.20.9-1.10.8-0.7-0.9
Bouts of movement, locomotor time 10.91.01.60.90.9-0.71.2-0.8-0.80.90.9-1.11.3-1.3-1.0
Total resting periods, locomotor time 10.60.61.00.70.7-0.61.0-0.6-0.60.80.7-0.91.0-1.0-0.7
Rest time, locomotor task time 10.30.41.40.1-0.40.2-0.70.20.2-0.5-0.30.7-1.21.20.3
Distance moved, locomotor task time 10.10.10.2-0.40.2-0.10.3-0.1-0.20.30.1-0.30.4-0.5-0.1
Vertical activity count, locomotor time 10.91.01.9-1.4-1.11.2-0.71.31.3-0.8-1.20.60.2-0.11.1
Time >=10cm from walls, locomotor time 20.30.30.70.80.6-0.70.4-0.7-0.70.50.6-0.3-0.10.0-0.4
Bouts of movement, locomotor time 20.10.10.3-0.1-0.20.5-0.50.40.3-0.3-0.20.3-0.30.10.2
Total resting periods, locomotor time 20.10.10.2-0.3-0.20.5-0.40.30.2-0.2-0.20.2-0.2-0.00.1
Rest time, locomotor task time 20.20.31.4-0.1-0.2-0.1-0.60.0-0.1-0.4-0.10.5-1.21.00.1
Distance moved, locomotor task time 21.01.12.20.30.9-0.91.2-0.9-0.91.11.0-1.21.5-1.4-0.7
Vertical activity count, locomotor time 20.30.31.0-1.0-0.60.6-0.20.70.7-0.3-0.40.10.5-0.40.8
Light reinforcement 10.71.23.1-1.8-1.21.1-1.11.11.1-1.1-0.91.1-0.80.81.0
Light reinforcement 20.00.10.3-0.4-0.1-0.2-0.00.10.1-0.00.20.00.3-0.6-0.3
Bone: marrow area1.12.54.2-0.8-1.51.4-1.71.61.5-1.7-1.61.6-2.02.01.2
Bone: maximum diameter0.00.10.10.3-0.00.00.00.30.3-0.1-0.4-0.00.3-0.3-0.2
Bone: maximum force0.10.30.40.2-0.40.2-0.50.60.5-0.6-0.60.5-0.60.60.5
Bone: maximum moment0.20.30.5-0.0-0.50.3-0.60.70.6-0.7-0.70.6-0.70.70.6
Mean time between licks in bursts4.46.28.12.02.6-2.52.7-2.3-2.22.52.3-2.62.8-2.8-2.5
Mean num. licks in bursts1.01.22.2-1.5-1.11.1-1.01.21.1-1.0-1.21.1-0.90.90.9
Cd content in liver1.51.62.30.81.5-1.11.4-1.2-1.31.41.1-1.51.4-1.2-1.0
Co content in liver0.00.00.2-0.5-0.20.2-0.00.30.2-0.2-0.10.00.0-0.10.3
Cu content in liver0.50.60.9-0.9-0.80.7-0.70.90.8-0.8-0.70.7-0.50.40.9
Fe content in liver0.50.62.00.20.5-0.50.8-0.5-0.50.70.7-0.81.3-1.4-0.2
K content in liver2.22.14.7-2.2-1.71.5-1.21.71.7-1.4-1.41.1-0.50.31.8
Mg content in liver2.32.35.4-2.3-1.71.6-1.21.81.8-1.5-1.51.2-0.40.31.7
Mn content in liver0.10.20.30.30.4-0.40.4-0.4-0.30.40.4-0.30.4-0.4-0.5
Na content in liver1.81.93.1-1.8-1.51.6-1.21.41.4-1.2-1.41.2-0.70.71.8
Rb content in liver0.50.71.1-0.40.8-0.70.8-0.8-0.70.90.8-1.01.1-1.0-0.4
Se content in liver0.10.10.4-0.7-0.40.5-0.20.40.4-0.3-0.30.20.0-0.10.2
Sr content in liver0.80.71.51.20.9-0.70.6-1.1-1.10.90.9-0.60.2-0.1-0.9
Zn content in liver1.21.31.7-1.3-1.21.2-1.11.21.1-1.2-1.11.0-1.11.11.1
Bone: minimum diameter4.78.710.6-2.3-3.22.7-3.03.23.1-3.3-3.13.1-2.92.82.7
Time in familiar zone, hab. session 10.10.10.6-0.1-0.10.1-0.30.00.0-0.2-0.10.3-0.70.80.3
Time in novel zone, hab. session 10.40.41.70.00.3-0.10.6-0.1-0.10.40.2-0.61.3-1.3-0.4
Total zone transitions, hab. session 10.20.30.6-0.6-0.60.6-0.60.70.7-0.7-0.50.7-0.50.40.3
Total locomotion distance, hab. session 11.52.13.2-1.1-1.51.4-1.61.31.3-1.6-1.21.7-1.81.61.0
Locomotion velocity, hab. session 11.11.63.0-0.9-1.31.2-1.41.11.1-1.4-1.01.5-1.71.60.8
Time in familiar zone, hab. session 20.00.00.10.30.1-0.20.1-0.2-0.20.20.3-0.10.1-0.10.1
Time in novel zone, hab. session 20.10.10.5-0.30.00.30.20.20.20.0-0.2-0.20.7-0.6-0.2
Total zone transitions, hab. session 20.00.00.20.50.1-0.2-0.0-0.1-0.1-0.10.20.1-0.30.2-0.3
Total locomotion distance, hab. session 20.30.41.0-0.2-0.70.5-0.70.50.5-0.7-0.50.9-1.00.90.3
Locomotion velocity, hab. session 20.40.51.2-0.2-0.70.4-0.80.50.5-0.7-0.50.9-1.11.00.3
Novel to familiar place preference ratio0.30.30.7-0.5-0.60.6-0.30.80.8-0.6-0.70.40.2-0.20.4
Novelty place preference0.20.20.5-0.5-0.40.5-0.10.60.7-0.4-0.60.20.5-0.50.2
Time in novel zone, NPP test0.40.40.9-0.7-0.60.7-0.30.90.9-0.6-0.80.40.4-0.40.5
Total zone transitions, NPP test0.10.10.2-0.5-0.30.4-0.20.30.3-0.3-0.30.3-0.20.20.2
Total locomotion distance, NPP test0.10.10.5-0.1-0.30.2-0.50.20.2-0.4-0.10.5-0.70.60.1
Locomotion velocity, NPP test0.00.00.20.20.0-0.1-0.1-0.2-0.2-0.10.30.2-0.40.3-0.2
Intraocular pressure0.60.91.40.31.1-1.01.2-1.0-0.81.00.7-1.11.2-1.0-0.7
Delta distance traveled before/after self-admin0.40.41.10.6-0.40.4-0.70.40.3-0.6-0.50.6-1.01.00.5
Delta ambulatory time before/after self-admin0.10.10.50.7-0.10.0-0.40.20.0-0.3-0.10.3-0.60.60.1
Parametrial fat weight1.83.56.0-0.9-2.02.5-1.92.12.1-1.9-2.11.8-1.41.51.8
Pavlov. Cond. lever latency0.81.01.71.31.1-1.00.9-1.2-1.21.11.0-1.10.6-0.4-1.0
Pavlov. Cond. magazine entry latency0.10.10.6-0.8-0.1-0.1-0.20.00.0-0.2-0.10.2-0.50.40.1
Pavlov. Cond. change in total contacts0.00.00.1-0.3-0.30.1-0.10.30.3-0.2-0.20.20.1-0.20.1
Pavlov. Cond. index score0.40.52.0-1.4-0.70.5-0.50.70.7-0.6-0.50.6-0.30.20.7
Pavlov. Cond. latency score0.40.51.7-1.3-0.80.6-0.60.80.8-0.8-0.70.7-0.50.30.7
Pavlov. Cond. lever contacts0.91.01.7-1.3-1.10.9-0.91.21.1-1.1-1.01.1-0.60.50.9
Pavlov. Cond. magazine entry number0.10.10.60.8-0.10.3-0.20.20.2-0.2-0.20.2-0.20.20.1
Pavlov. Cond. intertrial magazine entries0.50.61.5-0.8-0.91.1-0.70.90.9-0.8-0.70.6-0.20.11.2
Pavlov. Cond. lever-magazine prob. diff.0.40.51.9-1.4-0.80.5-0.60.70.7-0.7-0.60.7-0.50.30.7
Pavlov. Cond. response bias0.50.62.3-1.5-0.80.6-0.60.70.7-0.7-0.60.7-0.50.40.7
Pavlov. Cond. lever latency0.30.41.0-0.3-0.61.0-0.50.70.9-0.6-0.80.40.00.10.7
Pavlov. Cond. magazine entry latency1.11.32.10.91.2-1.51.1-1.4-1.31.11.3-1.00.7-0.8-1.2
Pavlov. Cond. change in total contacts0.71.02.00.91.1-1.40.8-1.1-1.20.91.2-0.80.3-0.4-1.1
Pavlov. Cond. index score1.11.42.81.11.3-1.71.1-1.4-1.51.21.4-1.00.4-0.5-1.3
Pavlov. Cond. latency score1.72.13.71.41.5-1.91.3-1.7-1.71.41.7-1.20.6-0.7-1.5
Pavlov. Cond. lever contacts0.20.30.90.40.5-0.90.3-0.6-0.70.40.7-0.2-0.30.2-0.5
Pavlov. Cond. magazine entry number2.12.64.5-1.4-1.72.1-1.61.81.8-1.6-1.81.4-1.01.11.7
Pavlov. Cond. intertrial magazine entries2.02.73.8-1.6-1.81.9-1.52.01.8-1.7-1.71.5-1.01.01.6
Pavlov. Cond. lever-magazine prob. diff.1.01.32.51.01.2-1.61.0-1.4-1.41.11.3-0.90.4-0.5-1.2
Pavlov. Cond. response bias0.81.12.40.91.2-1.60.9-1.3-1.31.01.2-0.80.2-0.3-1.1
Time in closed arm before self-admin0.60.71.5-0.1-0.80.7-1.20.90.7-0.8-0.80.9-1.00.90.7
Time in closed arm after self-admin0.60.61.81.30.9-0.60.5-0.7-1.00.80.8-0.80.3-0.1-0.8
Time in open arm before self-admin1.71.92.81.11.5-1.61.4-1.6-1.71.31.6-1.30.9-0.9-1.4
Time in open arm after self-admin1.71.92.7-1.5-1.61.5-1.21.41.6-1.4-1.41.4-1.00.81.5
Bone: periosteal estimation0.61.11.5-0.5-1.10.9-1.11.21.2-1.2-1.21.1-1.11.20.8
Bone: periosteal perimeter0.30.51.00.1-0.60.5-0.70.80.7-0.8-0.90.8-0.91.00.3
Bone: post-yield work0.20.20.4-0.5-0.50.4-0.40.60.6-0.5-0.50.4-0.20.20.7
Progressive ratio test 1 active lever presses0.30.31.8-1.30.1-0.40.2-0.1-0.40.20.5-0.40.4-0.60.0
Progressive ratio test 1 breakpoint0.30.31.3-1.10.3-0.60.3-0.3-0.50.40.6-0.50.4-0.5-0.1
Progressive ratio test 1 inactive lever presses2.42.73.6-1.1-1.81.6-1.91.71.7-1.8-1.61.7-1.71.51.4
Progressive ratio test 2 active lever presses0.20.21.7-1.3-0.10.2-0.30.00.2-0.1-0.30.2-0.10.20.3
Progressive ratio test 2 breakpoint0.10.11.2-1.1-0.10.0-0.1-0.10.1-0.0-0.20.10.1-0.00.2
Progressive ratio test 2 inactive lever presses0.91.11.7-1.0-1.01.1-1.10.80.9-1.0-1.01.1-1.31.30.9
Incentive Sensitization - Responses0.00.00.2-0.20.3-0.20.1-0.4-0.10.3-0.1-0.10.10.1-0.0
Incentive Sensitization - Breakpoint0.00.00.2-0.20.3-0.20.1-0.4-0.10.2-0.1-0.00.00.1-0.0
Sum of active levers in priming session hrs 5-61.11.12.8-1.7-0.90.6-1.00.90.9-1.0-0.91.1-1.11.10.9
Progressive ratio0.50.61.00.60.8-1.00.7-1.0-0.80.90.9-0.70.3-0.4-0.8
Food seeking constrained by brief footshock0.10.10.40.10.1-0.30.2-0.3-0.20.10.4-0.20.3-0.6-0.1
Seeking ratio, punishment vs. effort0.50.71.1-0.8-1.01.0-0.70.90.9-0.9-0.80.7-0.30.10.9
Retroperitoneal fat weight0.51.64.7-2.2-1.21.8-1.01.31.3-0.9-1.40.7-0.20.41.5
Reaction time number correct0.10.10.4-0.10.4-0.60.2-0.6-0.30.30.2-0.2-0.00.1-0.0
Reaction time mean minus median0.40.52.01.40.5-0.20.8-0.3-0.40.60.5-0.71.0-1.0-0.2
Reaction time mean minus median AUC0.20.31.00.70.20.10.60.10.00.30.1-0.51.0-1.00.2
Reaction time num false alarms0.40.61.7-1.3-0.90.9-0.40.90.9-0.6-0.60.50.2-0.10.7
Reaction time num false alarms AUC0.20.31.4-1.2-0.60.7-0.10.60.7-0.3-0.30.20.5-0.40.4
Reaction time trials correct on left0.10.10.4-0.10.4-0.60.2-0.6-0.30.30.2-0.2-0.00.1-0.0
Reaction time trials on left0.10.10.5-0.10.4-0.60.3-0.7-0.40.30.3-0.30.0-0.0-0.1
Reaction time mean0.70.92.71.60.8-0.51.0-0.5-0.70.90.7-1.01.1-1.3-0.5
Reaction time mean AUC0.40.61.51.20.6-0.30.9-0.3-0.50.70.6-0.81.1-1.2-0.3
Median of all reaction times0.60.82.11.40.8-0.51.0-0.6-0.70.80.7-1.01.1-1.3-0.5
Reaction time omissions1.11.51.90.41.3-1.01.4-1.2-1.31.41.3-1.41.3-1.2-1.0
Reaction time false alarm rate0.20.30.7-0.8-0.70.8-0.10.80.7-0.4-0.40.30.5-0.40.3
Reaction time premature initiation rate0.30.40.80.4-0.80.7-0.60.90.7-0.7-0.60.6-0.20.20.6
Reaction time premature initiations0.20.30.60.0-0.70.6-0.60.70.7-0.7-0.60.6-0.30.30.7
Std. dev. reaction times0.40.62.41.50.6-0.30.8-0.4-0.50.60.6-0.70.9-1.0-0.4
Reaction time trials completed0.10.10.5-0.10.4-0.60.3-0.7-0.40.30.3-0.30.0-0.0-0.1
Reaction time trials AUC0.10.20.5-0.00.5-0.70.3-0.7-0.40.40.3-0.40.2-0.1-0.2
Run reversals in cocaine runway, females2.42.43.1-1.4-1.71.5-1.81.31.5-1.6-1.31.7-1.61.41.4
Run reversals in cocaine runway, males0.20.20.30.40.6-0.40.5-0.5-0.50.50.4-0.40.3-0.0-0.3
Latency to leave start box in cocaine runway3.43.74.7-0.9-2.12.0-2.12.12.0-2.0-2.22.0-1.81.81.7
Latency to leave start box in cocaine runway, F5.05.47.2-1.5-2.52.5-2.42.52.5-2.5-2.72.5-2.12.11.9
Latency to leave start box in cocaine runway, M0.20.20.91.00.3-0.40.2-0.2-0.40.40.4-0.30.2-0.2-0.2
Std. dev. time between licks in bursts1.72.03.11.21.5-1.81.5-1.5-1.41.41.5-1.41.2-1.2-1.4
Total sessions with >9 infusions1.51.62.50.81.5-1.51.2-1.5-1.61.41.4-1.40.8-0.6-1.2
Short access day 1 total inactive lever presses0.91.02.6-0.2-0.80.7-1.30.60.5-0.9-0.71.0-1.61.60.6
Short access day 10 total inactive lever presses1.01.12.5-0.0-0.81.0-1.20.70.7-1.1-0.91.1-1.61.60.7
Short access day 1 total infusions0.20.20.6-0.8-0.40.2-0.40.40.3-0.4-0.20.3-0.30.20.5
Short access day 10 total infusions0.10.10.8-0.90.1-0.3-0.0-0.2-0.20.10.3-0.10.1-0.2-0.1
Short access total infusions0.10.20.4-0.70.3-0.40.3-0.3-0.40.40.5-0.40.3-0.3-0.1
Short access day 1 locomotion0.30.31.7-1.30.4-0.50.3-0.5-0.50.40.4-0.40.5-0.40.0
Short access day 10 total locomotion0.10.10.2-0.10.3-0.10.3-0.3-0.20.40.2-0.40.5-0.3-0.0
Short access total locomotion0.50.50.9-1.00.6-0.70.6-0.7-0.70.70.7-0.70.8-0.7-0.3
One hour access (0.3 mA shock)0.30.31.1-1.0-0.40.2-0.50.30.3-0.4-0.40.5-0.70.80.4
Compulsive drug intake0.60.60.9-0.8-0.90.8-0.61.01.0-0.8-0.90.7-0.40.40.7
One hour access (shock baseline)0.00.00.1-0.00.2-0.20.0-0.2-0.20.20.1-0.1-0.00.1-0.3
Social response proportion3.33.54.2-2.0-1.91.9-1.82.02.0-1.9-2.01.8-1.51.62.0
Social responses1.31.75.1-2.3-1.11.1-1.01.21.2-1.2-1.51.2-1.01.41.2
Social time1.11.52.0-1.1-1.21.2-1.21.21.2-1.2-1.41.2-1.01.21.4
Soleus weight0.61.73.11.71.5-1.31.1-1.5-1.41.31.3-1.20.3-0.2-1.8
Bone: stiffness1.11.72.6-1.3-1.41.3-1.21.61.5-1.3-1.51.1-0.70.71.5
Tibialis anterior weight4.013.816.62.64.0-3.73.9-3.6-3.63.93.7-4.14.0-4.0-3.4
Time to tail flick, vehicle, before self-admin0.60.61.51.2-0.70.7-0.81.00.7-0.7-0.70.7-0.80.60.1
Time to tail flick, vehicle, after self-admin0.40.52.00.8-0.20.1-0.7-0.00.0-0.4-0.30.7-1.31.40.1
Time to tail flick, test, before self-admin0.10.10.4-0.7-0.1-0.10.00.2-0.20.00.2-0.00.1-0.1-0.1
Time to tail flick, test, after self-admin1.51.62.6-0.8-1.41.5-1.31.61.2-1.3-1.31.2-1.21.21.1
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.5-0.10.1-0.2-0.10.1-0.2-0.30.3-0.40.60.3
Delta time to tail flick, test, before/after SA1.31.22.2-0.7-1.11.5-1.01.21.3-1.1-1.31.0-0.80.81.1
Tibia length0.10.30.5-0.2-0.60.5-0.70.60.7-0.6-0.60.5-0.40.20.4
Ambulatory time before self-admin1.11.17.3-2.7-0.90.7-0.70.50.8-0.7-0.60.8-0.60.71.2
Ambulatory time after self-admin2.93.15.1-2.1-1.71.3-1.81.21.4-1.7-1.41.8-2.22.21.9
Bone: tissue strength1.00.91.3-0.7-1.01.0-0.91.11.1-1.0-1.11.0-0.80.90.8
Total heroin consumption1.41.62.6-0.3-1.11.2-1.51.01.2-1.3-1.31.4-1.61.60.9
Bone: trabecular number0.10.10.4-0.40.1-0.20.3-0.2-0.20.30.3-0.30.5-0.60.2
Bone: trabecular spacing0.10.20.6-0.8-0.30.5-0.10.30.4-0.1-0.3-0.00.5-0.50.2
Bone: trabecular thickness0.10.10.4-0.2-0.20.2-0.30.10.1-0.2-0.10.3-0.60.70.4
Bone: trabecular tissue density0.30.51.00.70.6-0.50.7-0.4-0.50.60.4-0.71.0-1.0-0.7
Water consumed over 24 hours2.02.42.9-1.5-1.51.3-1.61.51.5-1.6-1.51.6-1.71.71.4
Number of responses in last shaping day0.30.30.70.10.5-0.80.6-0.4-0.60.50.6-0.60.7-0.8-0.3