RGD1359634

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	RGD1359634	0.03	0.02	2.1e-03	0.02	0.01	0	0.02	1.8e-03	3.9e-02	8.2e-02	6.4e-03
2	Liver	gene expression	RGD1359634	0.03	0.02	1.3e-03	0.02	0.02	0.02	0.02	1.7e-03	8.7e-04	4.5e-03	3.4e-03
3	BLA	intron excision ratio	chr7_110705984_110710575	0.08	0.05	5.1e-03	0.03	0.03	0.03	0.03	1.0e-02	7.9e-03	8.7e-03	9.6e-03
4	PL	intron excision ratio	chr7_110705984_110710575	0.1	0.04	1.3e-09	0.09	0.09	0.08	0.09	1.0e-09	1.9e-10	1.8e-09	3.0e-10
5	Brain	intron excision ratio	chr7_110705984_110710575	0.08	0.04	7.6e-07	0.09	0.08	0.08	0.08	2.0e-08	7.8e-08	7.2e-08	3.2e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.0	0.1	0.1	0.2	0.1	0.1	-0.3	0.3
Area under the delay curve	2.7	2.9	5.9	2.4	-2.0	1.1	1.3	-1.2
BMI with tail	0.2	0.5	1.7	-0.0	-0.2	1.3	0.2	-0.8
BMI without tail	0.4	0.7	1.5	1.2	-1.2	0.3	0.3	-0.6
Body weight	0.7	2.9	8.8	-3.0	2.2	0.5	-0.7	0.3
Weight adjusted by age	0.4	0.5	1.5	-0.7	1.2	-0.4	-0.3	0.5
Bone surface	0.1	0.3	0.6	0.1	-0.4	0.5	0.8	-0.5
Bone volume	0.0	0.0	0.1	0.3	-0.3	-0.1	0.1	0.1
Breakpoint value in progressive ratio session	0.4	0.4	1.1	1.1	-0.9	0.3	-0.2	-0.2
Number of licking bursts	0.7	0.8	1.6	1.3	-0.8	-1.0	-0.3	0.8
Context. condit. distance diff. score	1.6	1.9	5.5	-2.4	1.9	-0.4	-0.6	0.6
Locomotion velocity, session 1	0.8	0.8	1.9	-0.9	0.5	0.7	1.4	-0.9
Locomotion distance, session 1	2.7	3.5	5.2	2.3	-2.3	0.5	2.1	-1.5
Locomotion velocity, session 2	2.0	2.3	4.5	-0.1	-0.6	1.7	2.0	-2.1
Locomotion distance, session 2	2.6	3.7	5.8	2.1	-2.4	1.0	2.1	-1.7
Locomotion velocity, session 3	0.4	0.5	1.0	-1.0	0.4	-0.8	0.7	0.5
Locomotion distance, session 3	1.4	1.5	2.8	1.5	-1.2	-1.7	0.1	1.0
Stereotopy head waving bouts, day 3	0.5	0.6	1.3	-1.1	1.1	0.7	0.1	-0.4
Stereotopy head waving duration, day 3	2.2	2.6	6.4	-2.5	2.4	1.0	-0.0	-0.2
Locomotion velocity, session 7	0.7	0.7	1.5	-0.6	1.2	-0.7	-0.8	0.8
Locomotion distance, session 7	0.8	1.1	1.8	-0.5	1.2	-0.9	-1.0	1.3
Stereotopy head waving bouts, day 7	1.8	2.0	4.7	-2.2	1.8	0.9	0.8	-0.8
Stereotopy head waving duration, day 7	1.1	1.3	2.5	-1.6	1.3	1.0	0.8	-0.9
Locomotion velocity, session 8	1.3	1.6	3.3	-1.8	1.1	1.0	1.3	-0.8
Locomotion distance, session 8	0.2	0.3	0.6	-0.6	0.3	0.5	0.8	-0.6
Degree of sensitization distance	3.2	3.2	7.8	-2.5	2.8	0.7	-1.1	0.5
Degree of sensitization stereotypy	1.3	1.4	2.3	-1.5	1.0	0.9	1.3	-1.1
Conditioned locomotion	0.6	0.7	1.8	-1.0	1.3	-0.3	-0.7	0.5
Cocaine response after cond. corrected	0.6	0.6	1.5	-0.5	0.3	1.2	0.8	-0.9
Cocaine response after cond. not corrected	0.6	0.6	1.6	-0.3	-0.1	1.3	0.7	-1.0
Cocaine response before conditioning	0.3	0.4	0.9	0.8	-0.9	-0.4	-0.3	0.1
Saline control response	0.1	0.2	0.6	-0.8	0.3	-0.4	-0.1	0.2
Bone: connectivity density	0.2	0.3	0.4	-0.5	0.7	-0.4	-0.5	0.5
Bone: cortical apparent density	1.3	1.7	4.3	0.7	0.0	-2.1	-1.4	1.3
Bone: cortical area	0.1	0.1	0.3	-0.5	0.4	0.6	-0.1	-0.2
Bone: cortical porosity	1.2	1.3	3.0	-1.2	0.4	1.7	0.9	-1.0
Bone: cortical porosity	2.1	2.3	4.7	-1.5	0.4	2.2	1.5	-1.5
Bone: cortical thickness	0.4	0.6	1.9	1.1	-1.4	-0.0	-0.2	0.1
Bone: cortical thickness	0.6	0.7	2.1	1.2	-1.5	0.1	0.1	-0.1
Bone: cortical tissue density	1.2	1.6	4.3	0.6	0.1	-2.1	-1.4	1.3
Condit. Reinf. active minus inactive responses	0.7	0.8	1.9	0.0	0.1	-1.4	-0.9	1.1
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.8	-0.5	0.3	-1.4	-0.6	0.8
Condit. Reinf. active responses	1.6	2.0	3.7	0.7	-0.0	-1.9	-1.6	1.8
Condit. Reinf. inactive responses	1.9	2.3	4.0	1.2	-0.2	-1.7	-1.8	2.0
Incentive salience index mean	1.7	2.1	4.0	0.3	0.4	-2.0	-1.7	1.8
Condit. Reinf. lever presses	2.4	3.2	5.6	0.4	0.5	-2.2	-2.4	2.2
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	0.2	-0.6	1.0	0.9	-0.8
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.9	-0.4	0.1	0.9	0.6	-0.6
Condit. Reinf. active responses	1.1	1.5	2.7	-0.1	-0.7	1.5	1.6	-1.4
Condit. Reinf. inactive responses	0.5	0.6	1.4	0.3	-0.9	0.5	1.2	-0.8
Condit. Reinf. lever presses	0.2	0.2	0.6	0.8	-0.5	-0.2	-0.2	0.4
Condit. Reinf. lever reinforcers received	0.8	1.1	2.0	-0.3	-0.4	1.4	1.4	-1.2
Conditioned reinforcement - actives	1.4	1.4	3.4	0.9	-1.8	0.7	1.5	-0.6
Conditioned reinforcement - inactives	0.7	0.8	1.6	1.2	-1.3	-0.6	-0.4	0.8
Conditioned locomotion	1.4	1.7	3.1	-0.3	-1.4	1.7	1.7	-0.9
Patch foraging indifference point 0 sec	0.9	1.5	2.4	-0.8	1.0	-1.3	-1.2	1.6
Patch foraging indifference point AUC	0.6	0.7	1.7	0.9	-1.3	-0.5	0.6	0.3
Delay disc. indifference point, 0s delay	0.4	0.4	1.7	0.0	-0.3	1.3	0.0	-0.6
Delay disc. indifference point, 16s delay	2.6	2.6	4.7	2.2	-2.0	1.0	1.4	-1.2
Delay disc. indifference point, 2s delay	8.1	9.0	12.0	3.0	-3.5	2.9	2.8	-2.9
Delay disc. indifference point, 24s delay	0.4	0.4	1.5	0.2	0.2	-1.2	0.0	0.6
Delay disc. indifference point, 4s delay	2.4	2.5	2.9	1.7	-1.4	1.7	1.5	-1.7
Delay disc. indifference point, 8s delay	1.2	1.3	4.5	2.1	-1.2	-0.4	-0.0	0.3
Indifference point function ln k	0.7	1.0	2.6	-1.6	1.4	0.4	-0.3	-0.4
Indifference point function log k	0.7	1.0	2.6	-1.6	1.4	0.4	-0.3	-0.4
Patch foraging total patch changes 0 sec	0.6	1.0	1.9	-0.4	0.5	-1.2	-1.0	1.4
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.5	-0.1	-0.2	0.4	0.1
Patch foraging total patch changes 18 sec	0.3	0.4	1.2	-0.1	0.1	-0.7	-0.5	1.1
Patch foraging total patch changes 24 sec	1.1	1.3	2.6	0.7	-0.5	-1.6	-1.0	1.6
Patch foraging total patch changes 6 sec	0.2	0.3	0.9	0.1	-0.2	-0.7	-0.3	0.9
Patch foraging time to switch 0 sec	1.3	2.1	6.0	-0.0	-0.1	2.5	1.2	-1.7
Patch foraging water rate 0 sec	3.2	5.1	7.9	-0.9	1.7	-2.8	-2.5	2.7
Patch foraging water rate 12 sec	0.9	1.5	3.1	-0.0	0.5	-1.8	-1.6	1.1
Patch foraging water rate 18 sec	2.3	3.1	6.0	-0.6	1.4	-2.4	-1.7	2.1
Patch foraging water rate 24 sec	1.8	2.5	4.3	-1.9	2.1	-1.2	-1.4	0.9
Patch foraging water rate 6 sec	2.7	3.9	7.4	0.1	0.7	-2.7	-2.4	2.3
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.9	1.0	-0.5	0.5	0.7	-0.2
Distance traveled before self-admin	1.7	1.8	3.1	0.5	-1.5	1.8	1.3	-1.3
Distance traveled after self-admin	0.2	0.3	0.6	-0.7	0.8	0.0	-0.2	0.5
Extensor digitorum longus weight	0.5	2.0	4.5	2.1	-1.8	1.3	0.3	-0.6
Bone: elastic displacement	0.5	0.5	1.3	-1.0	1.2	0.2	-0.2	0.5
Bone: elastic work	1.7	2.3	4.1	-2.0	1.7	1.8	0.6	-1.0
Bone: endosteal estimation	1.0	2.1	4.8	-2.2	1.7	1.2	0.9	-0.8
Bone: endosteal perimeter	0.9	1.9	3.7	-1.9	1.7	1.3	0.7	-0.9
Epididymis fat weight	0.6	1.5	5.6	-2.4	1.0	0.4	0.1	-0.9
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	-0.1	-0.6	0.4	0.4	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.3	-0.3	0.4	0.3	-0.1
Diff in mean of infusions in LGA sessions	0.4	0.4	0.7	0.7	-0.3	-0.9	-0.3	0.7
Delay discount exponential model param	2.8	2.9	6.2	-2.5	2.1	-1.0	-1.4	1.2
Extinction: sum of active levers before priming	2.6	2.5	3.7	1.9	-1.9	1.2	1.5	-1.4
Active lever presses in extinction session 6	0.1	0.1	0.2	0.0	0.0	0.4	0.2	-0.4
Bone: final force	0.5	0.9	1.7	-0.8	0.6	1.3	0.6	-1.2
Bone: final moment	0.6	1.0	1.7	-1.0	0.8	1.3	0.5	-1.0
Food consumed during 24 hour testing period	0.3	0.4	0.7	-0.5	-0.3	0.9	0.7	-0.5
Glucose	0.9	1.3	3.0	-0.5	0.9	-0.7	-1.7	1.4
Heart weight	2.9	4.0	5.4	-2.1	2.3	-1.6	-2.2	1.8
Delay discount hyperbolic model param	3.5	3.7	6.7	-2.6	2.3	-1.4	-1.6	1.5
Intermittent access intake day 1-15 change	0.4	0.4	0.8	0.7	-0.6	-0.9	-0.3	0.5
Intermittent access intake escalation	0.5	0.5	0.9	0.9	-0.9	-0.7	-0.3	0.3
Intermittent access intake escalation 2	0.5	0.5	0.9	0.6	-0.4	-0.9	-0.8	0.7
Intermitt. access day 1 inactive lever presses	0.4	0.4	1.3	-0.6	1.1	-0.0	-0.4	0.4
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.7	-0.9	0.5	-0.4	-0.4	0.4
Intermitt. access escalation Index	0.4	0.3	0.8	0.6	-0.9	0.1	0.4	-0.4
Intermittent access day 1 total infusions	1.9	2.2	4.8	-0.6	-1.2	1.6	2.2	-1.3
Intermittent access day 15 total infusions	0.6	0.7	1.4	-0.1	-1.2	0.5	1.2	-0.6
Intermittent access terminal intake (last 3 days)	0.6	0.6	1.5	0.0	-1.1	0.4	1.2	-0.5
Intermittent access total infusions	1.8	2.0	3.9	-0.1	-1.4	1.5	2.0	-1.3
Intermittent access day 1 locomotion	0.5	0.5	0.9	-0.7	-0.5	0.9	0.9	-0.4
Intermittent access day 15 total locomotion	0.1	0.1	0.3	-0.5	-0.5	-0.2	0.1	0.2
Intermittent access total locomotion	0.3	0.3	1.4	-1.2	-0.1	0.3	-0.0	0.3
Intermittent access standard deviation	0.4	0.5	0.7	-0.9	-0.5	0.9	0.6	-0.4
Left kidney weight	2.9	8.0	26.3	-5.1	3.4	1.2	0.7	-0.3
Right kidney weight	4.0	11.2	37.3	-6.1	4.2	0.4	-0.5	0.6
Cocaine induced anxiety	0.3	0.3	0.9	-0.5	0.6	1.0	0.0	-0.2
Post-drug Anxiety	2.4	2.7	7.6	-1.8	2.8	-0.2	-1.2	0.9
Baseline Anxiety	2.6	2.8	4.3	-0.4	1.6	-2.1	-2.0	1.7
Tail length	0.6	1.7	2.8	-0.8	0.9	-1.7	-1.4	1.5
Length with tail	1.5	5.7	13.5	-3.7	3.1	-1.1	-1.4	1.5
Length without tail	2.1	4.7	14.6	-3.8	2.8	0.0	-0.6	0.6
Times rat made contact with spout	2.7	3.1	7.8	0.6	-0.1	-2.8	-1.8	2.1
Lifetime Intake	1.8	2.1	3.9	-0.2	-1.2	1.7	2.0	-1.4
Liver weight, left	0.7	1.1	2.2	-1.5	0.8	1.0	1.0	-0.8
Liver weight, right	0.7	1.1	3.7	-1.9	1.4	0.0	0.1	-0.1
Locomotor activity	0.5	0.8	2.9	-1.7	0.8	0.3	-0.1	-0.4
Locomotor testing distance	0.2	0.3	0.5	0.2	-0.7	-0.6	-0.6	0.2
Locomotor testing rearing	0.3	0.4	0.9	-0.9	-0.1	0.4	0.5	-0.9
Locomotion in novel chamber	1.6	1.9	3.1	1.8	-0.8	-1.7	-1.2	1.3
Locomotion in novel chamber post-restriction	1.9	2.3	5.0	2.2	-2.2	0.3	0.8	-0.9
Fecal boli incidents, locomotor time 1	0.3	0.4	0.7	0.3	0.7	-0.6	-0.5	0.8
Change in fecal boli incidents, locomotor task	0.3	0.3	0.9	-0.7	0.2	-0.9	-0.2	0.3
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.8	-1.3	0.8	0.7	0.2	0.0
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	0.3	-0.3	-0.2	0.1
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.4	0.5	-0.1	-0.3	0.2
Rest time, locomotor task time 1	0.7	0.8	1.3	-0.5	1.1	-0.7	-1.0	1.0
Distance moved, locomotor task time 1	0.2	0.2	0.6	-0.7	0.2	0.2	0.4	-0.4
Vertical activity count, locomotor time 1	2.4	2.5	3.9	-1.2	1.2	-1.5	-2.0	1.9
Time >=10cm from walls, locomotor time 2	2.3	2.4	3.7	-1.1	1.9	-1.3	-1.5	1.8
Bouts of movement, locomotor time 2	2.1	2.3	4.1	1.6	-2.0	1.3	1.0	-1.5
Total resting periods, locomotor time 2	3.0	3.2	5.2	1.7	-2.3	1.6	1.4	-1.8
Rest time, locomotor task time 2	0.1	0.1	0.3	0.5	-0.1	0.1	-0.1	-0.0
Distance moved, locomotor task time 2	0.6	0.7	1.6	-1.0	1.3	-0.5	-0.5	0.7
Vertical activity count, locomotor time 2	2.6	2.8	3.9	-1.1	1.7	-1.5	-2.0	2.0
Light reinforcement 1	0.1	0.1	0.2	-0.1	-0.0	0.4	0.5	-0.3
Light reinforcement 2	0.3	0.4	0.9	-0.2	-0.3	1.0	0.8	-0.7
Bone: marrow area	1.0	2.3	5.3	-2.3	1.7	1.3	0.9	-0.8
Bone: maximum diameter	1.1	2.1	5.2	-2.3	1.7	1.3	0.4	-0.7
Bone: maximum force	0.6	1.1	2.3	-1.1	0.7	1.5	0.8	-0.9
Bone: maximum moment	0.8	1.3	2.5	-1.3	0.9	1.6	0.8	-0.9
Mean time between licks in bursts	0.9	1.3	2.2	1.0	-0.6	1.4	1.0	-1.5
Mean num. licks in bursts	0.5	0.6	0.9	-0.9	0.6	-1.0	-0.7	0.5
Cd content in liver	0.8	0.9	1.6	-0.1	-1.0	1.0	0.9	-1.3
Co content in liver	0.1	0.1	0.3	0.2	-0.5	0.4	0.1	-0.3
Cu content in liver	1.7	2.1	7.2	2.7	-1.7	-0.4	0.0	-0.1
Fe content in liver	1.8	2.1	6.1	-2.5	2.0	0.5	-0.2	0.4
K content in liver	0.6	0.6	1.2	0.3	-0.4	0.9	0.9	-1.1
Mg content in liver	0.2	0.2	0.4	-0.0	-0.1	0.6	0.6	-0.6
Mn content in liver	0.7	0.8	2.0	1.1	-1.4	0.3	0.7	-0.5
Na content in liver	0.1	0.1	0.1	0.1	0.0	-0.3	-0.4	-0.1
Rb content in liver	0.2	0.3	0.8	-0.3	0.4	-0.4	-0.6	0.9
Se content in liver	0.7	0.9	2.4	1.2	-1.5	-0.1	0.5	-0.6
Sr content in liver	2.0	1.8	5.1	2.3	-1.9	-0.4	-0.2	0.1
Zn content in liver	0.6	0.7	1.5	1.2	-1.0	0.1	0.7	-0.8
Bone: minimum diameter	0.2	0.5	0.9	-0.9	0.3	0.9	0.6	-0.4
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.2	0.4	-0.0	0.0	0.1
Time in novel zone, hab. session 1	0.3	0.3	1.0	-1.0	0.2	0.5	0.2	-0.2
Total zone transitions, hab. session 1	1.1	1.5	3.6	1.8	-1.9	-0.7	0.6	0.1
Total locomotion distance, hab. session 1	0.4	0.6	1.3	0.7	-1.2	-0.9	0.2	0.3
Locomotion velocity, hab. session 1	0.4	0.6	1.5	0.8	-1.2	-1.0	0.1	0.3
Time in familiar zone, hab. session 2	0.5	0.5	1.0	0.7	-0.2	-1.0	-0.5	0.9
Time in novel zone, hab. session 2	0.5	0.4	0.8	-0.5	-0.4	0.9	0.5	-0.9
Total zone transitions, hab. session 2	0.3	0.4	0.6	0.8	-0.7	-0.7	0.3	0.7
Total locomotion distance, hab. session 2	0.2	0.3	0.7	0.2	-0.7	0.4	0.9	-0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.3	-0.5	0.1	0.5	0.2
Novel to familiar place preference ratio	0.6	0.6	2.3	-1.5	0.5	0.2	0.6	-0.3
Novelty place preference	0.6	0.6	2.7	-1.6	0.6	0.0	0.4	-0.2
Time in novel zone, NPP test	0.7	0.7	3.0	-1.7	0.6	-0.0	0.4	-0.1
Total zone transitions, NPP test	1.0	1.4	3.1	1.8	-1.6	-0.9	0.6	0.3
Total locomotion distance, NPP test	0.2	0.2	0.7	0.4	-0.5	-0.2	0.8	-0.1
Locomotion velocity, NPP test	0.3	0.4	0.9	0.9	-0.8	-0.3	0.7	-0.1
Intraocular pressure	0.3	0.4	0.7	-0.7	0.3	0.7	0.8	-0.7
Delta distance traveled before/after self-admin	2.9	3.1	5.5	-1.4	2.3	-1.8	-1.3	1.8
Delta ambulatory time before/after self-admin	2.4	2.6	5.8	-1.6	2.4	-1.5	-0.9	1.4
Parametrial fat weight	1.7	3.3	6.2	-0.2	1.2	-2.1	-2.5	2.0
Pavlov. Cond. lever latency	0.1	0.2	0.3	-0.4	0.1	0.5	0.5	-0.3
Pavlov. Cond. magazine entry latency	0.6	0.7	1.4	1.1	-1.2	0.7	0.4	-0.6
Pavlov. Cond. change in total contacts	0.6	0.7	1.7	1.0	-1.3	0.3	0.6	-0.6
Pavlov. Cond. index score	0.0	0.0	0.1	0.3	-0.2	0.0	-0.1	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.0	0.1	-0.1	0.0	-0.2	-0.1
Pavlov. Cond. lever contacts	0.2	0.2	0.4	0.5	-0.0	-0.4	-0.6	0.3
Pavlov. Cond. magazine entry number	0.3	0.4	0.9	-0.9	0.9	-0.2	-0.3	0.4
Pavlov. Cond. intertrial magazine entries	1.1	1.3	2.6	0.1	0.6	-1.6	-1.3	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.5	-0.5	-0.1	-0.1	-0.1
Pavlov. Cond. response bias	0.1	0.2	0.6	0.7	-0.5	-0.0	-0.2	0.0
Pavlov. Cond. lever latency	0.4	0.6	1.0	0.3	-1.0	0.3	0.9	-1.0
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	0.7	-0.4	-0.1	-0.4	0.5
Pavlov. Cond. change in total contacts	1.3	1.9	5.2	-1.6	2.3	0.4	-0.8	0.8
Pavlov. Cond. index score	0.4	0.5	1.1	0.1	0.6	-0.4	-0.9	1.0
Pavlov. Cond. latency score	0.6	0.8	1.7	0.1	0.7	-0.6	-1.2	1.3
Pavlov. Cond. lever contacts	0.6	0.8	1.6	-0.2	0.9	-0.6	-1.1	1.3
Pavlov. Cond. magazine entry number	0.3	0.3	0.8	-0.0	-0.5	0.3	0.7	-0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	-0.3	0.3	-0.6	-0.7	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	0.1	0.6	-0.2	-0.8	0.9
Pavlov. Cond. response bias	0.2	0.3	0.6	0.0	0.6	0.0	-0.6	0.7
Time in closed arm before self-admin	0.2	0.2	0.5	0.5	-0.3	0.3	-0.7	0.3
Time in closed arm after self-admin	0.8	0.9	1.4	-1.1	0.7	-0.4	-1.2	1.1
Time in open arm before self-admin	0.6	0.7	1.5	-0.1	0.9	-1.2	-0.7	0.7
Time in open arm after self-admin	0.2	0.3	0.5	0.6	-0.2	-0.7	-0.4	0.5
Bone: periosteal estimation	0.7	1.5	3.0	-1.7	1.2	1.3	0.7	-0.8
Bone: periosteal perimeter	1.1	1.8	4.6	-2.1	1.8	0.9	0.3	-0.5
Bone: post-yield work	0.1	0.2	0.4	0.3	-0.2	0.6	0.7	-0.2
Progressive ratio test 1 active lever presses	0.7	0.7	1.3	0.1	-1.0	0.9	1.2	-0.6
Progressive ratio test 1 breakpoint	0.3	0.3	0.7	0.1	-0.7	0.4	0.8	-0.3
Progressive ratio test 1 inactive lever presses	0.9	1.0	2.2	0.8	-1.1	1.5	0.7	-0.6
Progressive ratio test 2 active lever presses	0.5	0.5	1.6	0.8	-1.3	-0.4	0.3	0.3
Progressive ratio test 2 breakpoint	0.3	0.3	0.9	0.6	-1.0	-0.2	0.5	0.1
Progressive ratio test 2 inactive lever presses	0.9	1.0	2.5	1.4	-1.6	-0.1	0.6	-0.0
Incentive Sensitization - Responses	0.6	0.6	1.4	0.7	-0.6	-1.2	-0.5	0.8
Incentive Sensitization - Breakpoint	0.6	0.6	1.3	0.7	-0.6	-1.1	-0.4	0.8
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.5	0.3	-0.1	0.7	0.1	-0.3
Progressive ratio	0.2	0.2	0.5	-0.4	-0.0	0.7	0.6	-0.3
Food seeking constrained by brief footshock	0.5	0.6	1.0	-0.1	-0.7	0.7	0.9	-1.0
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	0.4	-0.3	-0.1	-0.1	-0.1
Retroperitoneal fat weight	1.5	5.0	14.3	-3.8	3.1	-0.0	-1.1	0.4
Reaction time number correct	0.7	1.1	2.4	1.5	-1.3	-0.9	0.6	-0.0
Reaction time mean minus median	0.0	0.0	0.1	-0.2	0.2	0.3	0.1	0.1
Reaction time mean minus median AUC	0.1	0.1	0.4	-0.6	0.4	0.2	-0.2	0.1
Reaction time num false alarms	0.0	0.0	0.1	-0.4	-0.2	-0.2	-0.1	-0.0
Reaction time num false alarms AUC	0.1	0.1	0.2	-0.3	-0.4	-0.2	0.2	-0.3
Reaction time trials correct on left	0.7	1.1	2.4	1.5	-1.3	-0.9	0.6	-0.0
Reaction time trials on left	0.9	1.2	2.7	1.6	-1.5	-0.9	0.6	-0.1
Reaction time mean	0.3	0.4	1.0	-0.6	1.0	0.1	-0.7	0.6
Reaction time mean AUC	0.2	0.2	0.5	-0.4	0.7	0.1	-0.4	0.6
Median of all reaction times	0.3	0.4	0.9	-0.5	1.0	0.2	-0.6	0.6
Reaction time omissions	3.1	4.3	5.9	1.7	-2.4	2.0	2.1	-2.1
Reaction time false alarm rate	0.1	0.2	0.6	-0.8	0.2	0.3	-0.2	-0.2
Reaction time premature initiation rate	0.2	0.2	0.6	-0.8	0.5	0.5	-0.1	-0.1
Reaction time premature initiations	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.0	0.1
Std. dev. reaction times	0.2	0.3	0.9	-0.9	0.7	0.1	-0.3	0.4
Reaction time trials completed	0.9	1.2	2.7	1.6	-1.5	-0.9	0.6	-0.1
Reaction time trials AUC	0.6	0.9	1.8	1.4	-1.3	-0.8	0.7	-0.1
Run reversals in cocaine runway, females	1.2	1.1	2.2	0.0	0.7	-1.5	-1.2	1.2
Run reversals in cocaine runway, males	0.4	0.4	1.4	-0.6	-0.0	-0.1	1.2	-0.5
Latency to leave start box in cocaine runway	1.8	2.0	3.7	-0.6	0.2	1.9	1.4	-1.9
Latency to leave start box in cocaine runway, F	1.7	1.8	3.6	0.3	-0.3	1.8	1.5	-1.9
Latency to leave start box in cocaine runway, M	1.0	1.0	1.4	-1.1	0.1	1.2	1.0	-1.1
Std. dev. time between licks in bursts	0.1	0.1	0.4	-0.3	0.7	0.1	0.0	-0.3
Total sessions with >9 infusions	0.3	0.3	0.6	-0.7	-0.2	0.6	0.8	-0.3
Short access day 1 total inactive lever presses	0.7	0.8	1.8	-1.3	0.5	1.1	0.8	-0.2
Short access day 10 total inactive lever presses	3.0	3.3	4.8	-1.5	2.2	-1.8	-1.8	1.7
Short access day 1 total infusions	0.3	0.3	0.9	-0.9	0.2	0.4	0.5	-0.1
Short access day 10 total infusions	2.1	2.3	4.3	-0.7	-0.9	1.9	2.1	-1.5
Short access total infusions	1.4	1.6	2.8	-1.0	-0.3	1.6	1.7	-1.2
Short access day 1 locomotion	0.5	0.5	1.1	-0.4	-0.7	0.9	1.0	-0.4
Short access day 10 total locomotion	0.3	0.4	1.0	-0.2	-0.4	-0.2	-1.0	0.9
Short access total locomotion	0.3	0.3	1.1	-1.1	0.1	0.6	0.1	0.3
One hour access (0.3 mA shock)	2.9	3.3	7.9	2.2	-2.8	0.6	1.5	-1.1
Compulsive drug intake	2.1	2.2	3.0	1.5	-0.6	-1.7	-1.7	1.5
One hour access (shock baseline)	1.3	1.5	2.5	0.4	-1.5	1.1	1.6	-1.2
Social response proportion	3.5	3.8	9.7	-0.2	-0.4	3.1	1.9	-2.3
Social responses	1.0	1.3	1.8	0.5	-0.9	1.4	1.4	-1.3
Social time	0.9	1.2	2.7	1.6	-1.5	0.7	0.5	-0.7
Soleus weight	1.6	4.6	8.5	0.6	0.5	-2.4	-2.9	2.9
Bone: stiffness	0.5	0.7	1.5	-1.2	1.2	0.8	-0.2	-0.1
Tibialis anterior weight	1.2	4.2	10.8	3.3	-3.1	0.7	0.4	-0.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.3	-0.3	0.2	0.3	-0.0
Time to tail flick, vehicle, after self-admin	0.8	0.8	1.3	-0.3	0.7	-1.1	-1.0	1.1
Time to tail flick, test, before self-admin	1.4	1.4	2.7	1.6	-1.6	0.2	1.0	-0.6
Time to tail flick, test, after self-admin	0.9	0.9	1.8	1.2	-0.2	-1.3	-0.7	0.9
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.0	0.3	-0.1	-0.0	0.1
Delta time to tail flick, test, before/after SA	1.5	1.4	2.5	0.3	0.3	-1.6	-1.5	1.4
Tibia length	0.2	0.5	1.0	-0.9	1.0	0.6	0.1	-0.3
Ambulatory time before self-admin	0.9	0.9	2.4	1.1	-1.5	0.7	0.5	-0.5
Ambulatory time after self-admin	0.2	0.3	0.3	-0.5	0.5	-0.6	-0.4	0.6
Bone: tissue strength	0.2	0.2	0.5	-0.7	0.5	0.5	-0.1	-0.0
Total heroin consumption	1.5	1.8	2.8	1.1	-1.7	0.9	1.4	-1.4
Bone: trabecular number	0.1	0.1	0.1	-0.2	0.4	-0.4	-0.4	0.4
Bone: trabecular spacing	0.2	0.2	0.5	-0.5	0.7	0.1	-0.3	0.6
Bone: trabecular thickness	0.2	0.2	0.5	0.2	0.1	-0.6	-0.7	0.6
Bone: trabecular tissue density	0.8	1.1	2.4	0.2	0.6	-1.1	-1.5	1.3
Water consumed over 24 hours	0.3	0.4	1.1	-0.2	-0.1	-1.1	-0.4	0.8
Number of responses in last shaping day	4.6	4.8	6.2	1.3	-2.5	2.4	2.4	-2.1