RGD1302996

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	isoform ratio	XM_006255918.4	0.03	0.03	7.3e-03	0.01	0.02	0	0.01	3.2e-02	2.4e-03	1.1e-01	1.6e-02
2	PL	isoform ratio	NM_213610.3	0.03	0.03	7.5e-03	0.01	0.01	0.02	0.01	2.2e-02	2.1e-02	2.1e-03	1.5e-02
3	Brain	mRNA stability	RGD1302996	0.12	0.07	1.1e-10	0.11	0.12	0.11	0.12	2.3e-10	3.5e-11	1.9e-10	4.2e-11
4	Liver	gene expression	RGD1302996	0.2	0.11	0.0e+00	0.16	0.15	0.14	0.16	1.4e-17	5.7e-16	3.9e-15	1.3e-17
5	Adipose	gene expression	RGD1302996	0.06	0.04	6.9e-06	0.05	0.04	0.04	0.05	1.8e-06	2.9e-05	1.2e-05	4.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.1	1.8	2.6	-1.6	-1.2	-1.1	-1.1	1.6
Area under the delay curve	1.4	1.5	2.6	0.1	1.1	1.6	1.5	-1.0
BMI with tail	1.3	4.3	7.7	-0.1	0.2	2.8	2.6	-2.6
BMI without tail	2.4	4.9	8.7	0.9	1.2	2.8	2.3	-2.9
Body weight	4.3	18.1	31.8	2.3	2.7	5.1	4.4	-5.6
Weight adjusted by age	2.1	2.4	4.2	1.3	1.1	1.7	1.4	-2.1
Bone surface	0.3	0.5	1.5	0.8	1.2	0.2	-0.2	-0.5
Bone volume	0.1	0.1	0.2	-0.3	0.3	0.4	0.0	-0.3
Breakpoint value in progressive ratio session	0.7	0.8	1.5	-0.1	0.0	-1.1	-1.2	1.1
Number of licking bursts	0.7	0.8	1.2	1.1	0.7	-0.9	-1.1	0.4
Context. condit. distance diff. score	5.1	6.2	11.1	1.4	-0.2	-3.3	-3.3	2.6
Locomotion velocity, session 1	0.2	0.2	0.3	0.5	0.3	-0.6	-0.5	0.4
Locomotion distance, session 1	0.7	0.9	1.9	-1.3	-1.4	-0.2	-0.0	0.8
Locomotion velocity, session 2	0.1	0.1	0.3	0.6	0.2	-0.2	-0.5	-0.0
Locomotion distance, session 2	0.4	0.5	0.8	-0.5	-0.9	-0.5	-0.6	0.8
Locomotion velocity, session 3	0.7	0.8	2.2	-0.9	-1.5	0.5	0.9	-0.2
Locomotion distance, session 3	1.2	1.4	1.9	-0.7	-1.4	-1.2	-1.1	1.3
Stereotopy head waving bouts, day 3	1.5	1.8	2.7	1.6	1.6	1.0	0.5	-1.6
Stereotopy head waving duration, day 3	1.1	1.3	1.7	1.2	1.3	0.9	0.8	-1.3
Locomotion velocity, session 7	3.2	3.5	5.6	-0.5	-1.5	-2.3	-2.1	2.4
Locomotion distance, session 7	3.3	4.3	6.5	-1.1	-2.0	-2.2	-2.2	2.5
Stereotopy head waving bouts, day 7	1.4	1.6	3.0	0.5	1.0	1.5	1.2	-1.7
Stereotopy head waving duration, day 7	1.9	2.3	4.6	0.8	1.2	1.8	1.4	-2.1
Locomotion velocity, session 8	2.6	3.1	7.8	2.8	1.9	-1.0	-1.8	-0.1
Locomotion distance, session 8	3.0	4.4	8.8	1.0	-0.7	-2.6	-3.0	2.2
Degree of sensitization distance	0.7	0.7	1.1	0.9	0.7	-0.9	-1.1	0.7
Degree of sensitization stereotypy	0.8	0.9	1.8	0.2	0.7	1.3	0.7	-1.4
Conditioned locomotion	0.6	0.6	1.1	0.9	0.8	0.7	0.5	-1.0
Cocaine response after cond. corrected	0.3	0.3	0.7	-0.3	-0.1	-0.7	-0.7	0.8
Cocaine response after cond. not corrected	0.6	0.7	1.9	1.1	1.4	-0.0	-0.4	-0.4
Cocaine response before conditioning	3.9	4.7	7.4	2.3	2.5	1.9	1.2	-2.7
Saline control response	1.7	2.3	4.3	-1.3	-1.1	1.7	2.1	-1.2
Bone: connectivity density	1.6	2.5	4.7	-0.8	-0.7	-2.0	-1.7	2.2
Bone: cortical apparent density	1.3	1.7	2.8	-1.7	-1.1	1.3	1.7	-0.4
Bone: cortical area	1.4	2.0	3.8	0.6	1.1	1.9	1.0	-1.9
Bone: cortical porosity	0.4	0.4	0.9	-0.4	0.1	0.9	0.8	-0.7
Bone: cortical porosity	0.5	0.6	0.9	0.7	0.9	0.7	0.4	-1.0
Bone: cortical thickness	2.8	4.6	9.1	-1.7	-0.7	3.0	2.5	-2.0
Bone: cortical thickness	1.9	2.2	3.4	-1.8	-1.6	1.4	1.7	-0.5
Bone: cortical tissue density	1.1	1.4	2.6	-1.5	-0.9	1.1	1.6	-0.4
Condit. Reinf. active minus inactive responses	0.6	0.6	1.2	-0.1	-0.2	-1.0	-0.9	1.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.5	-0.1	0.2	0.4	0.1
Condit. Reinf. active responses	0.9	1.1	2.2	-0.5	-0.8	-1.2	-1.0	1.5
Condit. Reinf. inactive responses	1.8	2.2	3.5	-1.4	-1.9	-1.3	-1.0	1.8
Incentive salience index mean	1.7	2.0	4.1	0.9	0.7	-1.7	-2.0	1.4
Condit. Reinf. lever presses	2.9	3.9	7.6	1.3	1.0	-2.4	-2.8	1.9
Condit. Reinf. active minus inactive responses	0.9	1.1	2.0	0.8	0.9	1.1	0.9	-1.4
Condit. Reinf. active-inactive response ratio	2.1	2.2	3.6	1.4	1.6	1.4	0.9	-1.9
Condit. Reinf. active responses	0.0	0.0	0.0	0.1	-0.0	-0.0	0.1	-0.0
Condit. Reinf. inactive responses	1.1	1.3	2.4	-0.8	-1.2	-1.3	-0.6	1.6
Condit. Reinf. lever presses	0.3	0.3	0.5	-0.3	-0.7	-0.7	-0.4	0.7
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	0.2	0.0	-0.3	-0.1	0.1
Conditioned reinforcement - actives	0.3	0.3	0.6	0.1	0.4	0.7	0.6	-0.8
Conditioned reinforcement - inactives	1.0	1.1	2.2	-0.4	0.2	1.4	1.5	-1.2
Conditioned locomotion	0.1	0.1	0.4	0.4	0.6	-0.0	0.1	0.0
Patch foraging indifference point 0 sec	1.1	1.7	2.5	-1.6	-1.4	1.2	1.5	-0.6
Patch foraging indifference point AUC	1.6	1.8	3.4	0.7	0.7	1.6	1.4	-1.9
Delay disc. indifference point, 0s delay	1.0	1.1	4.1	0.9	2.0	0.4	0.2	-0.5
Delay disc. indifference point, 16s delay	1.7	1.7	3.6	-1.4	-0.4	1.6	1.9	-0.3
Delay disc. indifference point, 2s delay	2.0	2.2	3.7	1.1	1.7	1.4	1.1	-1.9
Delay disc. indifference point, 24s delay	0.4	0.4	0.9	-0.4	0.0	0.9	1.0	-0.5
Delay disc. indifference point, 4s delay	2.4	2.6	5.2	1.3	2.3	1.6	1.3	-1.3
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	-0.0	0.3	0.7	0.6	-0.2
Indifference point function ln k	0.5	0.7	1.5	0.6	0.7	-1.0	-1.2	0.6
Indifference point function log k	0.5	0.7	1.5	0.6	0.7	-1.0	-1.2	0.6
Patch foraging total patch changes 0 sec	1.4	2.2	3.2	-1.8	-1.5	1.5	1.8	-0.7
Patch foraging total patch changes 12 sec	1.5	1.9	3.5	-1.5	-1.1	1.5	1.9	-0.8
Patch foraging total patch changes 18 sec	2.8	3.6	7.5	-2.6	-2.7	1.1	1.6	-0.1
Patch foraging total patch changes 24 sec	2.4	2.9	7.7	-2.8	-2.3	0.2	0.8	0.7
Patch foraging total patch changes 6 sec	1.9	2.8	4.5	-2.1	-1.8	1.5	1.8	-0.8
Patch foraging time to switch 0 sec	0.7	1.1	2.4	-1.6	-1.5	-0.2	0.5	0.6
Patch foraging water rate 0 sec	0.3	0.4	0.9	-0.0	0.2	0.9	0.6	-0.9
Patch foraging water rate 12 sec	0.3	0.5	1.3	-1.1	-1.0	0.1	0.0	0.4
Patch foraging water rate 18 sec	0.1	0.1	0.3	0.4	0.4	0.5	0.1	-0.2
Patch foraging water rate 24 sec	1.1	1.5	2.9	0.1	0.2	1.7	1.5	-1.5
Patch foraging water rate 6 sec	0.2	0.3	0.8	-0.9	-0.9	0.4	0.1	-0.1
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.5	0.4	0.5	0.7	0.5	-0.7
Distance traveled before self-admin	0.3	0.3	0.8	0.9	0.5	-0.4	-0.6	0.1
Distance traveled after self-admin	0.3	0.4	0.8	0.9	0.8	0.1	-0.2	-0.5
Extensor digitorum longus weight	0.2	0.8	2.1	1.4	1.2	-0.2	-0.3	-0.4
Bone: elastic displacement	0.4	0.5	1.0	-1.0	-0.4	0.7	0.9	-0.4
Bone: elastic work	1.4	1.8	3.3	-0.1	0.9	1.8	1.4	-1.7
Bone: endosteal estimation	3.6	7.8	17.8	4.2	3.8	0.8	0.4	-2.4
Bone: endosteal perimeter	2.4	5.0	13.3	3.6	3.0	-1.0	-1.3	-0.6
Epididymis fat weight	6.1	14.3	23.7	-4.9	-4.0	3.4	4.4	-1.0
Delta time in closed arm before/after self-admin	0.2	0.1	0.4	0.2	0.6	0.4	0.4	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.3	-0.5	0.2	0.3	-0.1
Diff in mean of infusions in LGA sessions	2.2	2.4	3.6	-1.1	-1.1	-1.8	-1.9	1.6
Delay discount exponential model param	1.4	1.4	2.5	-0.1	-1.1	-1.6	-1.5	1.1
Extinction: sum of active levers before priming	0.4	0.4	1.1	-0.5	-0.4	-0.6	-0.5	1.0
Active lever presses in extinction session 6	0.6	0.6	1.6	-1.0	-1.3	0.1	0.5	0.2
Bone: final force	4.0	6.5	12.9	-0.1	0.7	3.6	2.9	-3.2
Bone: final moment	3.6	5.8	11.7	-0.0	0.7	3.4	2.7	-3.1
Food consumed during 24 hour testing period	0.7	0.9	1.8	1.3	1.0	0.6	0.2	-1.1
Glucose	4.6	7.0	12.2	3.5	3.3	-2.1	-2.7	0.6
Heart weight	0.2	0.3	0.8	0.5	0.9	0.3	0.3	-0.4
Delay discount hyperbolic model param	1.5	1.6	2.4	-0.3	-1.3	-1.6	-1.5	1.2
Intermittent access intake day 1-15 change	0.4	0.4	1.0	-0.0	-0.1	1.0	0.7	-0.7
Intermittent access intake escalation	0.2	0.2	0.4	0.6	0.4	0.4	0.1	-0.5
Intermittent access intake escalation 2	1.3	1.3	3.6	1.9	1.3	-0.5	-1.0	0.1
Intermitt. access day 1 inactive lever presses	0.7	0.8	2.5	1.2	1.6	0.0	-0.1	-0.4
Intermitt. access day 15 inactive lever presses	1.8	2.0	4.3	0.3	0.2	1.7	1.6	-2.1
Intermitt. access escalation Index	1.8	1.6	3.2	-0.4	-0.2	-1.8	-1.3	1.7
Intermittent access day 1 total infusions	0.3	0.3	0.8	-0.5	-0.3	-0.6	-0.4	0.9
Intermittent access day 15 total infusions	0.1	0.1	0.1	-0.4	-0.3	-0.0	-0.1	0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	-0.2	0.0	0.4	0.3	-0.1
Intermittent access total infusions	0.1	0.1	0.2	-0.4	-0.4	0.1	0.1	0.1
Intermittent access day 1 locomotion	0.4	0.4	0.7	0.6	0.7	-0.6	-0.4	0.8
Intermittent access day 15 total locomotion	0.9	1.0	2.2	1.2	1.5	0.7	0.1	-0.7
Intermittent access total locomotion	0.4	0.5	1.1	1.1	1.0	0.5	0.2	-0.3
Intermittent access standard deviation	1.7	1.8	3.8	-0.4	-0.1	2.0	1.9	-1.2
Left kidney weight	2.8	7.8	13.9	1.1	1.2	3.5	3.2	-3.7
Right kidney weight	2.3	6.4	10.1	1.9	2.0	2.9	2.5	-3.2
Cocaine induced anxiety	2.0	2.3	4.8	0.9	0.0	-2.1	-2.2	1.2
Post-drug Anxiety	0.7	0.8	1.8	0.6	-0.1	-1.3	-1.3	0.3
Baseline Anxiety	0.3	0.3	0.7	-0.9	-0.3	0.4	0.6	-0.3
Tail length	4.1	12.4	19.2	4.3	4.4	2.7	1.6	-3.8
Length with tail	3.4	12.4	17.8	3.7	3.8	3.3	2.4	-4.2
Length without tail	2.4	5.2	8.0	1.8	2.1	2.4	2.1	-2.8
Times rat made contact with spout	1.8	2.1	4.5	-2.1	-1.9	-0.5	-0.2	1.4
Lifetime Intake	0.0	0.0	0.0	-0.2	-0.0	0.1	0.1	-0.1
Liver weight, left	0.9	1.4	3.2	1.8	1.6	0.3	0.1	-1.0
Liver weight, right	3.8	6.3	11.3	3.3	3.4	1.4	0.8	-2.6
Locomotor activity	1.8	2.9	7.2	2.7	2.1	0.4	0.0	-1.7
Locomotor testing distance	0.3	0.5	1.4	1.2	0.8	0.0	-0.1	-0.7
Locomotor testing rearing	0.7	1.0	2.2	1.5	1.2	0.4	0.2	-1.1
Locomotion in novel chamber	0.6	0.8	1.0	0.4	0.9	0.9	0.9	-1.0
Locomotion in novel chamber post-restriction	0.4	0.5	1.0	-0.2	0.2	1.0	0.9	-0.6
Fecal boli incidents, locomotor time 1	0.5	0.5	0.9	-0.3	-0.7	-1.0	-0.8	0.6
Change in fecal boli incidents, locomotor task	0.8	0.7	1.4	0.7	1.1	0.6	0.3	-1.2
Time >=10cm from walls, locomotor time 1	0.9	0.9	2.1	1.4	0.7	0.2	-0.0	-1.4
Bouts of movement, locomotor time 1	1.2	1.3	2.4	0.6	0.4	-1.4	-1.3	1.6
Total resting periods, locomotor time 1	0.9	1.0	1.7	0.8	0.7	-1.0	-1.0	1.3
Rest time, locomotor task time 1	0.6	0.7	1.9	1.4	1.0	-0.4	-0.7	-0.2
Distance moved, locomotor task time 1	0.6	0.6	1.3	-0.6	-0.4	1.0	1.1	-0.6
Vertical activity count, locomotor time 1	0.5	0.6	1.1	-0.7	-0.6	0.8	1.1	-0.5
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.9	1.0	0.7	-0.2	-0.1	-0.8
Bouts of movement, locomotor time 2	1.4	1.5	3.9	1.8	2.0	0.3	0.1	-0.8
Total resting periods, locomotor time 2	1.8	1.9	5.0	2.1	2.2	-0.1	-0.4	-0.6
Rest time, locomotor task time 2	2.2	2.5	5.5	2.4	1.8	-1.2	-1.5	0.0
Distance moved, locomotor task time 2	1.3	1.5	2.3	-1.4	-1.2	1.2	1.5	-0.6
Vertical activity count, locomotor time 2	0.4	0.5	1.1	-1.0	-0.8	0.4	0.6	-0.1
Light reinforcement 1	0.3	0.5	1.1	-1.0	-0.6	0.6	0.8	-0.1
Light reinforcement 2	0.5	0.6	1.1	0.8	1.0	0.8	0.4	-0.8
Bone: marrow area	3.6	7.7	17.4	4.2	3.8	0.8	0.5	-2.4
Bone: maximum diameter	1.6	2.9	6.9	2.6	2.5	0.1	-0.8	-1.0
Bone: maximum force	3.3	5.7	11.1	0.2	0.9	3.3	2.6	-3.1
Bone: maximum moment	3.0	5.2	9.9	0.3	0.9	3.1	2.5	-3.0
Mean time between licks in bursts	2.2	3.0	6.4	2.5	2.1	-1.1	-1.7	0.0
Mean num. licks in bursts	1.4	1.7	4.3	-2.1	-1.6	0.6	1.0	0.3
Cd content in liver	0.8	0.8	1.1	-1.0	-1.0	1.0	0.9	-0.6
Co content in liver	1.8	2.1	4.6	-1.1	-0.8	1.6	2.1	-1.1
Cu content in liver	2.9	3.6	6.0	-2.5	-2.2	-1.3	-0.7	2.1
Fe content in liver	0.9	1.1	2.1	-1.0	-0.9	1.0	1.5	-0.7
K content in liver	0.2	0.2	0.5	0.0	0.3	-0.5	-0.7	0.4
Mg content in liver	2.9	3.0	5.4	1.3	1.3	-2.1	-2.3	1.4
Mn content in liver	4.1	4.7	7.9	2.8	2.6	-2.0	-2.1	0.7
Na content in liver	0.1	0.1	0.1	-0.3	-0.4	0.4	-0.4	-0.2
Rb content in liver	0.6	0.8	1.3	-0.4	-0.3	-1.1	-1.0	1.2
Se content in liver	3.3	4.0	5.9	2.4	2.4	-1.7	-2.3	0.7
Sr content in liver	1.2	1.1	3.1	1.3	1.8	0.4	0.2	-0.8
Zn content in liver	0.3	0.3	1.2	0.5	1.1	-0.2	-0.1	-0.0
Bone: minimum diameter	2.0	3.7	8.9	3.0	2.8	0.1	-0.7	-1.2
Time in familiar zone, hab. session 1	3.8	3.6	7.4	-2.3	-2.7	-1.1	-0.4	2.0
Time in novel zone, hab. session 1	2.4	2.4	5.5	2.0	2.3	0.6	0.4	-1.4
Total zone transitions, hab. session 1	0.6	0.8	1.4	-0.5	-1.1	-0.9	-0.6	1.2
Total locomotion distance, hab. session 1	0.4	0.6	1.1	-0.6	-0.8	-0.7	-0.7	1.1
Locomotion velocity, hab. session 1	0.3	0.4	0.7	-0.7	-0.9	-0.3	-0.3	0.7
Time in familiar zone, hab. session 2	0.5	0.5	1.4	-0.9	-1.2	-0.3	0.0	0.7
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.3	0.6	0.5	0.7	-0.7
Total zone transitions, hab. session 2	0.2	0.3	1.0	-0.6	-1.0	0.2	0.1	0.2
Total locomotion distance, hab. session 2	0.9	1.2	2.0	-0.9	-1.3	-1.0	-0.9	1.4
Locomotion velocity, hab. session 2	1.0	1.3	2.1	-0.8	-1.1	-1.1	-1.1	1.5
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.5	-0.4	0.2	0.0	0.0
Novelty place preference	0.1	0.1	0.2	-0.3	-0.1	0.4	0.2	-0.2
Time in novel zone, NPP test	0.1	0.1	0.3	-0.1	0.0	0.5	0.3	-0.4
Total zone transitions, NPP test	1.0	1.4	2.2	-0.6	-1.4	-1.2	-1.1	1.5
Total locomotion distance, NPP test	1.1	1.5	2.2	-1.2	-1.5	-1.0	-0.8	1.4
Locomotion velocity, NPP test	1.7	2.3	3.6	-1.4	-1.7	-1.4	-1.2	1.9
Intraocular pressure	0.9	1.2	1.8	-0.7	-1.3	-1.0	-1.0	1.3
Delta distance traveled before/after self-admin	0.7	0.8	1.3	0.2	0.4	1.1	1.0	-1.1
Delta ambulatory time before/after self-admin	0.4	0.5	1.0	0.6	0.6	0.5	0.5	-1.0
Parametrial fat weight	1.7	3.2	6.2	-0.1	-0.2	2.4	2.5	-2.1
Pavlov. Cond. lever latency	2.9	3.7	6.5	-2.2	-2.1	1.7	2.6	-0.7
Pavlov. Cond. magazine entry latency	2.2	2.8	4.7	1.9	1.3	-1.7	-2.2	0.9
Pavlov. Cond. change in total contacts	1.5	1.6	3.8	2.0	1.7	0.0	-0.8	-0.7
Pavlov. Cond. index score	3.4	4.2	7.6	2.4	1.9	-1.9	-2.7	0.9
Pavlov. Cond. latency score	3.2	4.0	6.9	2.5	2.1	-1.6	-2.6	0.5
Pavlov. Cond. lever contacts	2.7	3.2	5.2	2.3	2.1	-1.2	-2.3	0.1
Pavlov. Cond. magazine entry number	1.9	2.4	3.8	-1.4	-0.8	2.0	1.9	-1.3
Pavlov. Cond. intertrial magazine entries	1.5	1.8	4.2	-2.1	-1.8	0.0	0.7	0.9
Pavlov. Cond. lever-magazine prob. diff.	3.3	4.2	7.6	2.3	1.8	-2.0	-2.8	1.0
Pavlov. Cond. response bias	2.8	3.5	6.0	2.0	1.4	-2.0	-2.4	1.1
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.6	0.7	0.4	0.2	-0.5
Pavlov. Cond. magazine entry latency	0.5	0.6	1.0	0.7	1.0	0.6	0.1	-1.0
Pavlov. Cond. change in total contacts	0.2	0.3	0.5	-0.6	-0.3	0.7	0.6	-0.6
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	-0.1	0.1	0.0	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.1	-0.0	0.3	0.3	-0.4
Pavlov. Cond. lever contacts	0.4	0.6	1.5	-1.2	-1.2	0.0	0.3	0.3
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	-0.1	-0.3	-0.7	-0.3	0.8
Pavlov. Cond. intertrial magazine entries	1.5	1.9	3.1	1.3	0.7	-1.8	-1.7	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	-0.0	0.1	0.1	-0.2
Pavlov. Cond. response bias	0.1	0.2	0.4	-0.5	-0.7	-0.1	-0.2	0.2
Time in closed arm before self-admin	0.1	0.1	0.3	-0.2	-0.6	-0.1	-0.2	-0.5
Time in closed arm after self-admin	0.7	0.8	1.3	-0.5	-0.4	1.1	1.1	-1.0
Time in open arm before self-admin	0.6	0.6	0.7	0.8	0.9	-0.7	-0.6	0.8
Time in open arm after self-admin	0.6	0.6	1.1	0.5	0.2	-1.1	-0.8	1.0
Bone: periosteal estimation	2.7	5.6	9.2	2.9	3.0	1.7	1.0	-2.6
Bone: periosteal perimeter	1.7	2.8	5.8	2.4	2.3	0.7	-0.1	-1.6
Bone: post-yield work	0.7	1.0	2.9	1.7	1.0	-0.6	-0.7	0.1
Progressive ratio test 1 active lever presses	0.1	0.1	0.4	-0.1	0.2	-0.3	-0.2	0.6
Progressive ratio test 1 breakpoint	0.1	0.1	0.4	-0.2	0.1	-0.3	-0.1	0.6
Progressive ratio test 1 inactive lever presses	0.3	0.3	1.0	-1.0	-0.6	0.2	0.3	0.3
Progressive ratio test 2 active lever presses	0.5	0.5	0.7	-0.7	-0.7	-0.6	-0.8	0.8
Progressive ratio test 2 breakpoint	1.0	1.1	1.7	-0.9	-1.1	-0.8	-1.0	1.3
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.7	0.5	0.2	0.5	0.3	-0.9
Incentive Sensitization - Responses	0.6	0.6	0.9	-0.5	-0.8	-0.6	-0.9	0.9
Incentive Sensitization - Breakpoint	0.8	0.8	1.2	-0.5	-0.9	-0.8	-1.1	1.0
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.3	-0.2	-0.7	-0.5	0.6
Progressive ratio	3.6	4.1	7.0	0.2	1.1	2.7	2.5	-2.4
Food seeking constrained by brief footshock	0.0	0.0	0.2	-0.1	-0.4	-0.1	0.1	0.1
Seeking ratio, punishment vs. effort	3.0	3.7	6.5	-0.2	-1.1	-2.5	-2.3	2.3
Retroperitoneal fat weight	0.3	0.9	2.0	0.0	0.3	1.3	1.4	-1.0
Reaction time number correct	0.8	1.2	2.5	-1.6	-1.4	0.7	1.0	-0.1
Reaction time mean minus median	2.4	3.2	8.3	2.9	1.9	-1.2	-1.6	0.2
Reaction time mean minus median AUC	1.7	2.3	5.2	2.3	1.4	-1.2	-1.5	0.4
Reaction time num false alarms	0.3	0.4	0.7	0.6	0.8	0.6	0.3	-0.7
Reaction time num false alarms AUC	0.5	0.7	1.2	0.8	1.1	0.8	0.6	-0.9
Reaction time trials correct on left	0.8	1.2	2.5	-1.6	-1.4	0.7	1.0	-0.1
Reaction time trials on left	0.8	1.1	2.1	-1.5	-1.4	0.7	1.0	-0.2
Reaction time mean	2.6	3.7	6.7	2.6	2.2	-1.6	-2.1	0.6
Reaction time mean AUC	2.6	3.5	6.7	2.6	2.0	-1.5	-2.0	0.7
Median of all reaction times	1.9	2.6	3.9	2.0	1.9	-1.3	-1.8	0.6
Reaction time omissions	1.7	2.3	5.2	2.3	1.4	-1.2	-1.7	0.4
Reaction time false alarm rate	0.9	1.3	3.4	1.6	1.8	0.2	-0.1	-0.6
Reaction time premature initiation rate	1.0	1.3	2.6	0.2	0.2	1.5	1.3	-1.6
Reaction time premature initiations	1.5	2.1	3.6	-0.6	-0.4	1.9	1.8	-1.7
Std. dev. reaction times	2.8	3.9	9.6	3.1	2.5	-1.1	-1.6	0.0
Reaction time trials completed	0.8	1.1	2.1	-1.5	-1.4	0.7	1.0	-0.2
Reaction time trials AUC	0.8	1.1	2.2	-1.5	-1.4	0.7	0.9	-0.1
Run reversals in cocaine runway, females	0.8	0.8	1.6	-1.3	-1.2	0.6	0.8	0.2
Run reversals in cocaine runway, males	2.0	1.9	4.4	2.1	1.9	0.1	-0.1	-1.3
Latency to leave start box in cocaine runway	0.2	0.2	0.9	0.1	-0.1	0.2	0.3	-0.9
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	0.2	-0.6	-0.6	-0.5	-0.2
Latency to leave start box in cocaine runway, M	1.2	1.1	2.0	-0.4	-0.0	1.4	1.4	-1.2
Std. dev. time between licks in bursts	2.5	3.0	6.8	2.6	2.3	-0.8	-1.3	-0.3
Total sessions with >9 infusions	0.1	0.1	0.4	0.2	0.6	0.2	0.2	-0.2
Short access day 1 total inactive lever presses	1.3	1.5	3.4	1.9	1.8	-0.3	-0.7	-0.5
Short access day 10 total inactive lever presses	0.2	0.2	0.6	0.8	0.7	-0.2	-0.3	-0.1
Short access day 1 total infusions	0.3	0.3	0.4	0.2	0.6	-0.7	-0.5	0.6
Short access day 10 total infusions	0.0	0.0	0.1	0.0	0.1	0.3	0.1	-0.1
Short access total infusions	0.1	0.1	0.2	0.2	0.4	0.2	0.2	-0.2
Short access day 1 locomotion	2.5	2.7	4.8	-0.2	-0.2	-2.0	-2.1	2.2
Short access day 10 total locomotion	1.1	1.3	2.8	1.7	1.6	-0.4	-0.6	0.6
Short access total locomotion	0.5	0.5	0.8	0.7	0.9	-0.6	-0.6	0.8
One hour access (0.3 mA shock)	0.4	0.4	0.9	-0.1	-0.0	-0.9	-0.7	0.9
Compulsive drug intake	2.2	2.2	4.2	0.0	0.3	-2.1	-1.9	1.8
One hour access (shock baseline)	0.4	0.4	0.9	0.5	-0.0	0.8	0.7	-0.9
Social response proportion	0.6	0.6	1.9	1.1	1.4	-0.1	0.1	-0.2
Social responses	0.2	0.3	0.5	0.5	0.7	0.3	0.6	-0.3
Social time	2.3	3.0	7.5	2.7	2.4	-0.7	-1.0	-0.3
Soleus weight	2.3	6.7	16.4	4.0	3.8	-0.6	-1.2	-1.0
Bone: stiffness	0.9	1.4	2.9	-0.5	-0.3	1.7	1.5	-1.2
Tibialis anterior weight	0.3	1.0	2.5	-1.6	-1.3	0.6	0.7	0.0
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	0.5	-0.4	-0.4	-0.6	-0.4
Time to tail flick, vehicle, after self-admin	1.2	1.3	2.5	1.1	0.7	-1.3	-1.6	0.7
Time to tail flick, test, before self-admin	0.4	0.4	1.0	-0.5	-1.0	0.4	0.5	-0.6
Time to tail flick, test, after self-admin	1.1	1.1	2.4	0.6	-0.1	-1.2	-1.5	1.2
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.2	-0.1	0.1	-0.9	-1.0	1.1
Delta time to tail flick, test, before/after SA	1.1	1.0	2.2	-0.2	-0.4	-1.0	-1.2	1.5
Tibia length	2.5	7.2	12.3	3.3	3.5	1.8	1.2	-2.8
Ambulatory time before self-admin	0.1	0.1	0.2	0.3	0.5	-0.0	-0.1	0.1
Ambulatory time after self-admin	0.2	0.2	0.7	0.8	0.4	0.0	-0.1	-0.5
Bone: tissue strength	2.8	2.7	5.4	-0.0	0.5	2.3	1.6	-2.2
Total heroin consumption	0.0	0.0	0.0	0.0	0.1	-0.1	-0.2	0.2
Bone: trabecular number	1.3	2.0	3.4	-1.8	-1.4	-1.0	-1.0	1.7
Bone: trabecular spacing	2.7	3.6	6.4	1.7	1.5	2.0	1.5	-2.5
Bone: trabecular thickness	0.9	1.0	1.6	-1.2	-0.7	-0.9	-0.9	1.3
Bone: trabecular tissue density	1.2	1.6	3.0	0.4	0.6	1.7	1.3	-1.7
Water consumed over 24 hours	0.1	0.2	0.4	0.5	0.6	-0.2	-0.2	-0.1
Number of responses in last shaping day	0.6	0.7	1.7	0.8	1.3	0.3	-0.1	-1.0